keyword
MENU ▼
Read by QxMD icon Read
search

Capacity

keyword
https://www.readbyqxmd.com/read/29150936/the-roles-of-wnt-%C3%AE-catenin-pathway-in-tissue-development-and-regenerative-medicine
#1
REVIEW
Maryam Majidinia, Javad Aghazadeh, Rana Jahanban-Esfahlani, Bahman Yousefi
Regenerative medicine is a translational field which combines tissue engineering and molecular biology to construct spare organs or help injured or defective tissues to regenerate or restore their normal functions. This is particularly important with specific organs such as heart, central nervous system, retina or limbs which possess very limited regenerative capacity. As such, regenerative medicine has received peculiar attention in the last decade. In this regard, Wnt/β-catenin signaling pathway has been subject to intensive research, since it plays many essential roles in the regulation of the progenitor cell fate, developmental decisions, proliferation during embryonic development, and adult tissue homeostasis...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29150863/family-behaviours-that-have-an-impact-on-the-self-management-activities-of-adults-living-with-type-2-diabetes-a-systematic-review-and-meta-synthesis
#2
J Vongmany, T Luckett, L Lam, J L Phillips
AIMS: To identify family behaviours that adults with Type 2 diabetes' perceive as having an impact on their diabetes self-management. BACKGROUND: Research suggests that adults with Type 2 diabetes perceive that family members have an important impact on their self-management; however, it is unclear which family behaviours are perceived to influence self-management practices. METHODS: This meta-synthesis identified and synthesized qualitative studies from the databases EMBASE, Medline and CINAHL published between the year 2000 and October 2016...
November 18, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29150762/seasonal-influence-on-adherence-to-and-effects-of-an-interval-walking-training-program-on-sedentary-female-college-students-in-japan
#3
Aiko Tanabe, Shizue Masuki, Ken-Ichi Nemoto, Hiroshi Nose
Habitual exercise training is recommended to young people for their health promotion, but adherence may be influenced by atmospheric temperature (T a ) if performed outdoors. We compared the adherence to and the effects of a home-based interval walking training (IWT) program on sedentary female college students between winter and summer. For summer training over 176 days, 48 subjects (18-22 years old) were randomly divided into two groups: the control group (CNTsummer, n = 24), which maintained a sedentary lifestyle as before, and the IWT group (IWTsummer, n = 24), which performed IWT while energy expenditure was monitored by accelerometry...
November 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29150736/effect-of-erythrocyte-sperm-separation-medium-on-nuclear-acrosomal-and-membrane-maturity-parameters-in-human-sperm
#4
Bikem Soygur, Soner Celik, Ciler Celik-Ozenci, Leyla Sati
PURPOSE: The purpose of this study is to investigate whether erythrocyte-sperm separation medium (ESSM) has effects on human sperm motility, morphology, viability, membrane maturity, acrosome integrity, and nuclear attributes before and after cryopreservation. METHODS: Semen samples from normozoospermic (n = 36) and oligozoospermic (n = 9) patients were analyzed. Samples from the same patient were divided into three aliquots: group 1 and group 2 were resuspended in sperm washing media and ESSM, respectively...
November 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29150719/preoperative-optimization-for-major-hepatic-resection
#5
REVIEW
Sarah Walcott-Sapp, Kevin G Billingsley
PURPOSE: Major hepatic resections are performed for primary hepatobiliary malignancies, metastatic disease, and benign lesions. Patients with chronic liver disease, including cirrhosis and steatosis, are at an elevated risk of malnutrition and impaired strength and exercise capacity, deficits which cause increased risk of postoperative complications and mortality. The aims of this report are to discuss the pathophysiology of changes in nutrition, exercise capacity, and muscle strength in patient populations likely to require major hepatectomy, and review recommendations for preoperative evaluation and optimization...
November 18, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29150717/genetic-diversity-and-phylogenetic-study-of-the-chinese-gelao-ethnic-minority-via-23-y-str-loci
#6
Pengyu Chen, Yanyan Han, Guanglin He, Haibo Luo, Tianzhen Gao, Feng Song, Dengfu Wan, Jian Yu, Yiping Hou
Haplotype diversity for 23 Y chromosomal short tandem repeat (Y-STR) loci included in the PowerPlex(®) Y23 System was analyzed in the Chinese Gelao minority group of 234 unrelated males living in Daozhen Gelao-Miao Autonomous County in Guizhou Province, southwest China. A total of 216 different haplotypes were detected, of which 199 haplotypes were unique. The overall haplotype diversity (HD) and discrimination capacity (DC) were 0.9996 and 0.9231, respectively. The gene diversity (GD) ranged from 0.4159 (DYS438) to 0...
November 17, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29150696/impact-of-prolonged-overfeeding-on-skeletal-muscle-mitochondria-in-healthy-individuals
#7
Frederico G S Toledo, Darcy L Johannsen, Jeffrey D Covington, Sudip Bajpeyi, Bret Goodpaster, Kevin E Conley, Eric Ravussin
AIMS/HYPOTHESES: Reduced mitochondrial capacity in skeletal muscle has been observed in obesity and type 2 diabetes. In humans, the aetiology of this abnormality is not well understood but the possibility that it is secondary to the stress of nutrient overload has been suggested. To test this hypothesis, we examined whether sustained overfeeding decreases skeletal muscle mitochondrial content or impairs function. METHODS: Twenty-six healthy volunteers (21 men, 5 women, age 25...
November 17, 2017: Diabetologia
https://www.readbyqxmd.com/read/29150677/phosphatidylserine-decarboxylase-ct699-lysophospholipid-acyltransferase-ct775-and-acyl-acp-synthase-ct776-provide-membrane-lipid-diversity-to-chlamydia-trachomatis
#8
Eric Soupene, Frans A Kuypers
De novo lipid synthesis and scavenging of fatty acids (FA) are processes essential for the formation of the membrane of the human pathogen Chlamydia trachomatis (C.t.). Host FA are assimilated via esterification by the bacterial acyl-acyl carrier protein (ACP) synthase AasC but inhibitors of the host acyl-CoA synthetase enymes ACSL also impaired growth of C.t. in human cells. In E. coli, activity of AasC was sensitive to triacsin C and rosiglitazone G. The absence of a triacsin C-insensitive pathway and the increased inhibition by rosiglitazone G confirmed the sensitivity of the bacterial acyl-ACP synthase to these drugs in infected human cells...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150672/fmnh2-dependent-monooxygenases-initiate-catabolism-of-sulfonamides-in-microbacterium-sp-strain-br1-subsisting-on-sulfonamide-antibiotics
#9
Benjamin Ricken, Boris A Kolvenbach, Christian Bergesch, Dirk Benndorf, Kevin Kroll, Hynek Strnad, Čestmír Vlček, Ricardo Adaixo, Frederik Hammes, Patrick Shahgaldian, Andreas Schäffer, Hans-Peter E Kohler, Philippe F-X Corvini
We report a cluster of genes encoding two monooxygenases (SadA and SadB) and one FMN reductase (SadC) that enable Microbacterium sp. strain BR1 and other Actinomycetes to inactivate sulfonamide antibiotics. Our results show that SadA and SadC are responsible for the initial attack of sulfonamide molecules resulting in the release of 4-aminophenol. The latter is further transformed into 1,2,4-trihydroxybenzene by SadB and SadC prior to mineralization and concomitant production of biomass. As the degradation products lack antibiotic activity, the presence of SadA will result in an alleviated bacteriostatic effect of sulfonamides...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150666/dogs-reaction-to-inequity-is-affected-by-inhibitory-control
#10
Désirée Brucks, Friederike Range, Sarah Marshall-Pescini
Inequity aversion is thought to act as a mechanism to ensure cooperation and has been studied in many different species, consistently revealing inter-individual variation. Inhibitory control has been proposed to act as one factor responsible for this variation since individuals need to inhibit performing the required action and/or refuse rewards in order to exhibit inequity aversion. Here, we investigated if dogs' sensitivity to inequity is affected by their capacity for inhibitory control, assessed in a test battery and questionnaire...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150635/one-pot-synthesis-of-trifunctional-chitosan-edta-%C3%AE-cyclodextrin-polymer-for-simultaneous-removal-of-metals-and-organic-micropollutants
#11
Feiping Zhao, Eveliina Repo, Dulin Yin, Li Chen, Simo Kalliola, Juntao Tang, Evgenia Iakovleva, Kam Chiu Tam, Mika Sillanpää
The global contamination of water resources with inorganic and organic micropollutants, such as metals and pharmaceuticals, poses a critical threat to the environment and human health. Herein, we report on a bio-derived chitosan-EDTA-β-cyclodextrin (CS-ED-CD) trifunctional adsorbent fabricated via a facile and green one-pot synthesis method using EDTA as a cross-linker, for the adsorption of toxic metals and organic micropollutants from wastewater. In this system, chitosan chain is considered as the backbone, and the immobilized cyclodextrin cavities capture the organic compounds via host-guest inclusion complexation, while EDTA-groups complex metals...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150595/notch1-signaling-activation-contributes-to-adult-hippocampal-neurogenesis-following-traumatic-brain-injury
#12
Ming Tu, Penglei Zhu, Shaobo Hu, Wei Wang, Zhipeng Su, Jiaqing Guan, Chongran Sun, Weiming Zheng
BACKGROUND Neural stem cells are reported to exist in the hippocampus of adult mammals and are important sources of neurons for repair. The Notch1 signaling pathway is considered as one of the important regulators of neural stem cells, but its role in adult brains is unclear. We aimed to describe the role of Notch1 signaling in the adult rat hippocampus after traumatic brain injury. MATERIAL AND METHODS The model rats were randomly divided into 4 groups as follows: sham, sham-TBI, sham-Ad-TBI, and NICD-Ad-TBI...
November 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29150563/nfat5-regulated-macrophage-polarization-supports-the-proinflammatory-function-of-macrophages-and-t-lymphocytes
#13
Mónica Tellechea, Maria Buxadé, Sonia Tejedor, Jose Aramburu, Cristina López-Rodríguez
Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in their microenvironment. This functional plasticity involves a precise orchestration of gene expression patterns whose transcriptional regulators have not been fully characterized. We had previously identified the transcription factor NFAT5 as an activator of TLR-induced responses, and in this study we explore its contribution to macrophage functions in different polarization settings...
November 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29150514/sinorhizobium-meliloti-glutathione-reductase-is-required-for-both-redox-homeostasis-and-symbiosis
#14
Guirong Tang, Ningning Li, Yumin Liu, Liangliang Yu, Junhui Yan, Li Luo
Glutathione (L-γ-glutamyl-L-cysteinylglycine; GSH), one of the key antioxidants in Sinorhizobium meliloti, is required for the development of alfalfa (Medicago sativa) nitrogen-fixing nodules. Glutathione exists either in a reduced form (GSH) or an oxidized form (GSSG), and its content is regulated by two pathways in S. meliloti The first pathway is the de novo synthesis of glutathione from its constituent amino acids, namely, Glu, Cys, and Gly, catalyzed by γ-glutamyl cysteine synthetase (GshA) and glutathione synthetase (GshB)...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150507/divalent-metal-cations-potentiate-the-predatory-capacity-of-amoeba-for-cryptococcus-neoformans
#15
Man Shun Fu, Arturo Casadevall
Among the best studied interaction between soil phagocytic predators and a human pathogenic fungus is that of Acanthamoeba castellanii and Cryptococcus neoformans The experimental conditions used in amoeba-fungal confrontation assays can have major effects on whether the fungus or the protozoan is ascendant in the interaction. In the presence of Mg(2+) and Ca(2+) in PBS, C. neoformans was consistently killed when incubated with A. castellanii. A. castellanii survived better in the presence of Mg(2+) and Ca(2+), even when incubated with C...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150495/small-dense-high-density-lipoproteins-display-potent-vasorelaxing-activity-reflecting-their-elevated-content-of-sphingosine-1-phosphate
#16
Laurence Persegol, Maryam Darabi, Carolane Dauteuille, Marie Lhomme, Sandrine Chantepie, Kerry-Anne Rye, Patrice Therond, M John Chapman, Robert Salvayre, Anne Negre-Salvayre, Philippe Lesnik, Serge Monier, Anatol Kontush
AIMS: Functional heterogeneity of HDL is attributed to its diverse bioactive components. We evaluated whether vasodilatory effects of HDL differed across HDL subpopulations, reflecting their distinct molecular composition. METHODS: Capacity of five major HDL subfractions to counteract inhibitory effects of oxidized low-density lipoprotein on acetylcholine-induced vasodilation was tested in a rabbit aortic rings model. Nitric oxide (NO) production, an essential pathway in endothelium-dependent vasorelaxation, was studied in SV40-transformed murine endothelial cells (SVEC)...
November 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/29150452/a-metabolic-hypothesis-for-the-evolution-of-temperature-effects-on-the-arterial-pco2-and-ph-of-vertebrate-ectotherms
#17
Stanley S Hillman, Michael S Hedrick
Body temperature increases in ectothermic vertebrates characteristically lead to both increases in arterial PCO2 (PaCO2) and declines in resting arterial pH (pHa) of about 0.017 pH units/°C increase in temperature. This 'alphastat' pH pattern has previously been interpreted as being evolutionarily-driven by the maintenance of a constant protonation state on the imidazole moiety of histidine protein residues, hence stabilizing protein structure-function. Analysis of the existing data for interclass responses of ectothermic vertebrates show different degrees of PaCO2 increases and pH declines with temperature between the classes with reptiles>amphibians>fish...
November 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29150450/aerobic-power-and-flight-capacity-in-birds-a-phylogenetic-test-of-the-heart-size-hypothesis
#18
Roberto F Nespolo, César González-Lagos, Jaiber J Solano-Iguaran, Magnus Elfwing, Alvaro Garitano-Zavala, Santiago Mañosa, Juan Carlos Alonso, Jordi Altimiras
Flight capacity is one of the most important innovations in animal evolution; it only evolved in insects, birds, mammals and the extinct pterodactyls. Given that powered flight represents a demanding aerobic activity, an efficient cardiovascular system is essential for the continuous delivery of oxygen to the pectoral muscles during flight. It is well known that the limiting step in the circulation is stroke volume (the volume of blood pumped from the ventricle to the body during each beat), which is determined by the size of the ventricle...
November 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29150361/post-translational-mechanisms-of-host-subversion-by-bacterial-effectors
#19
REVIEW
Nichollas E Scott, Elizabeth L Hartland
Bacterial effector proteins are a specialized class of secreted proteins that are translocated directly into the host cytoplasm by bacterial pathogens. Effector proteins have diverse activities and targets, and many mediate post-translational modifications of host proteins. Effector proteins offer potential in novel biotechnological and medical applications as enzymes that may modify human proteins. Here, we discuss the mechanisms used by effectors to subvert the human host through blocking, blunting, or subverting immune mechanisms...
November 14, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29150341/increased-prevalence-of-clinical-and-subclinical-atherosclerosis-in-patients-with-damaging-mutations-in-abca1-or-apoa1
#20
Omar Abdel-Razek, Singh N Sadananda, Xuan Li, Lubomira Cermakova, Jiri Frohlich, Liam R Brunham
BACKGROUND: A low level of high-density lipoprotein cholesterol (HDL-C) is a common clinical scenario and poses challenges for management. Many patients with low HDL-C harbor a damaging mutation in ABCA1 or APOA1, but the clinical implications of genetic testing for these mutations are unclear. OBJECTIVE: The purpose of this study was to investigate the prevalence of clinical or subclinical atherosclerosis among patients with low HDL-C due to a mutation in ABCA1 or APOA1, compared with patients with low HDL-C without such a mutation...
November 10, 2017: Journal of Clinical Lipidology
keyword
keyword
77585
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"