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Ronco C.

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https://www.readbyqxmd.com/read/29473534/the-enriched-proanthocyanidin-extract-of-ligaria-cuneifolia-shows-a-marked-hypocholesterolemic-effect-in-rats-fed-with-cholesterol-enriched-diet
#1
Jose Enrique Gonzalvez, Gloria Garcia, Sebastian Galliano, Alicia Dominighini, Leda Urli, Juan Monti, Maria Teresa Ronco, Daniel Frances, Marcelo Wagner, Cristina Ester Carnovale, Alejandra Nora Luquita
BACKGROUND: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. OBJECTIVE: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma Cho levels, the hemorheological parameters, and biliary secretion. METHOD: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days...
February 22, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29453769/hpv-genotyping-for-the-cross-sectional-and-longitudinal-probability-of-developing-cin2
#2
Annarosa Del Mistro, Rachael Adcock, Francesca Carozzi, Anna Gillio-Tos, Laura De Marco, Salvatore Girlando, Raffaella Rizzolo, Helena Frayle, Morena Trevisan, Cristina Sani, Elena Burroni, Paolo Giorgi Rossi, Jack Cuzick, Guglielmo Ronco
HPV testing is more sensitive but less specific than cytology. We evaluated stand-alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing to conventional cytology, HPV positive women were referred to colposcopy and followed up if no high-grade lesion was detected. HPV positive samples were genotyped by GP5+/GP6+ primed PCR followed by reverse line blot. Genotypes were hierarchically ordered by positive predictive value (PPV) for CIN grade 2 or more (CIN2+), and grouped by cluster analysis into 3 groups (A, B and C in decreasing order)...
February 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29426404/genomic-investigation-of-staphylococcus-aureus-isolates-from-bulk-tank-milk-and-dairy-cows-with-clinical-mastitis
#3
Troels Ronco, Ilka C Klaas, Marc Stegger, Line Svennesen, Lærke B Astrup, Michael Farre, Karl Pedersen
Staphylococcus aureus is one of the most common pathogens that cause mastitis in dairy cows. Various subtypes, virulence genes and mobile genetic elements have been associated with isolates from bulk tank milk and clinical mastitis. So far, no Danish cattle associated S. aureus isolates have been whole-genome sequenced and further analyzed. Thus, the main objective was to investigate the population structure and genomic content of isolates from bulk tank milk and clinical mastitis, using whole-genome sequencing...
February 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29195078/a-next-generation-connectivity-map-l1000-platform-and-the-first-1-000-000-profiles
#4
Aravind Subramanian, Rajiv Narayan, Steven M Corsello, David D Peck, Ted E Natoli, Xiaodong Lu, Joshua Gould, John F Davis, Andrew A Tubelli, Jacob K Asiedu, David L Lahr, Jodi E Hirschman, Zihan Liu, Melanie Donahue, Bina Julian, Mariya Khan, David Wadden, Ian C Smith, Daniel Lam, Arthur Liberzon, Courtney Toder, Mukta Bagul, Marek Orzechowski, Oana M Enache, Federica Piccioni, Sarah A Johnson, Nicholas J Lyons, Alice H Berger, Alykhan F Shamji, Angela N Brooks, Anita Vrcic, Corey Flynn, Jacqueline Rosains, David Y Takeda, Roger Hu, Desiree Davison, Justin Lamb, Kristin Ardlie, Larson Hogstrom, Peyton Greenside, Nathanael S Gray, Paul A Clemons, Serena Silver, Xiaoyun Wu, Wen-Ning Zhao, Willis Read-Button, Xiaohua Wu, Stephen J Haggarty, Lucienne V Ronco, Jesse S Boehm, Stuart L Schreiber, John G Doench, Joshua A Bittker, David E Root, Bang Wong, Todd R Golub
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that we term L1000. We show that L1000 is highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29148022/hemodialysis-versus-peritoneal-dialysis-an-observational-study-in-two-international-centers
#5
Renhua Lu, Carla Estremadoyro, Xiaohuan Chen, Mingli Zhu, Leonardo C Ribeiro, Yucheng Yan, Alessandra Brendolan, Wei Fang, Carlo Crepaldi, Zhaohui Ni, Leyi Gu, Claudio Ronco
INTRODUCTION: Given that it is difficult to randomize end-stage renal disease (ESRD) patients to either hemodialysis (HD) or peritoneal dialysis (PD), differences between these renal replacement therapy (RRT) modalities are of major interest and remain controversial. METHODS: All data on maintenance dialysis patients during 2009 to 2013 in the Renji Hospital in Shanghai, China and in the San Bortolo Hospital in Vicenza, Italy were selected. Patients who changed their therapy from HD to PD or PD to HD during this study were excluded...
November 8, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29147074/increased-levels-of-srage-in-diabetic-ckd-g5d-patients-a-potential-protective-mechanism-against-age-related-upregulation-of-fibroblast-growth-factor-23-and-inflammation
#6
Elena Dozio, Valentina Corradi, Elena Vianello, Elisa Scalzotto, Massimo de Cal, Massimiliano Marco Corsi Romanelli, Claudio Ronco
Advanced glycation end products (AGEs) may induce cardiac remodeling in kidney disease by promoting fibroblast growth factor 23 (FGF-23) expression. Since AGEs are increased in diabetes mellitus (DM), our first aim was to evaluate the existence of any potential association between AGEs, FGF-23, inflammation, and increased cardiovascular risk in DM patients on dialysis (CKD-G5D). Secondarily, we explored the potential role of the soluble receptor for AGEs (sRAGE) as a marker of heart failure. Levels of glycated albumin (GA), sRAGE, c-terminal FGF-23 (cFGF-23), brain natriuretic peptide (BNP), and inflammatory mediators were compared between DM and non-DM CKD-G5D patients...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29073601/early-continuous-veno-venous-hemofiltration-is-effective-in-decreasing-intra-abdominal-pressure-and-serum-interleukin-8-level-in-severe-acute-pancreatitis-patients-with-abdominal-compartment-syndrome
#7
Jianmin Xu, Ying Cui, Xiangping Tian
OBJECTIVE: The aim of this study was to evaluate the efficacy of early continuous veno-venous hemofiltration (CVVH) in decreasing the intra-abdominal pressure (IAP) and serum interleukin-8 (IL-8) level in severe acute pancreatitis (SAP) patients with abdominal compartment syndrome (ACS). METHODS: Twenty-five ACS patients of SAP were enrolled in a prospective study conducted according to the standard management protocol. They were treated in the intensive care unit (ICU) of Affiliated Yidu Central Hospital of Weifang Medical College and underwent CVVH...
October 25, 2017: Blood Purification
https://www.readbyqxmd.com/read/29023830/drug-management-in-acute-kidney-disease-report-of-the-acute-disease-quality-initiative-xvi-meeting
#8
Marlies Ostermann, Lakhmir S Chawla, Lui G Forni, Sandra L Kane-Gill, John A Kellum, Jay Koyner, Patrick T Murray, Claudio Ronco, Stuart L Goldstein
AIMS: To summarize and extend the main conclusions and recommendations relevant to drug management during acute kidney disease (AKD) as agreed at the 16th Acute Disease Quality Initiative (ADQI) consensus conference. METHODS: Using a modified Delphi method to achieve consensus, experts attending the 16th ADQI consensus conference reviewed and appraised the existing literature on drug management during AKD and identified recommendations for clinical practice and future research...
February 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28915542/comparative-susceptibility-of-two-neotropical-predators-eriopis-connexa-and-chrysoperla-externa-to-acetamiprid-and-pyriproxyfen-short-and-long-term-effects-after-egg-exposure
#9
Federico Rimoldi, Marilina N Fogel, Alicia E Ronco, Marcela I Schneider
Compatibility assessments between selective insecticides and the natural enemies of pests are essential for integrated-pest-management programs. Chrysoperla externa and Eriopis connexa are two principal Neotropical predators of agricultural pests whose conservation in agroecosystems requires a toxicity evaluation of pesticides to minimize the impact on those beneficial insects on the environment. The objective of this work was to evaluate the toxicity of the insecticides pyriproxyfen and acetamiprid on C. externa and E...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28903092/lethal-and-sublethal-effects-of-the-pirimicarb-based-formulation-aficida%C3%A2-on-boana-pulchella-dum%C3%A3-ril-and-bibron-1841-tadpoles-anura-hylidae
#10
G S Natale, J Vera-Candioti, C Ruiz de Arcaute, S Soloneski, M L Larramendy, A E Ronco
Acute lethal and sublethal toxicity of the pirimicarb-based commercial formulation Aficida® were evaluated on Boana pulchella tadpoles. Whereas mortality was used as end point for lethality, frequency of micronuclei and other nuclear abnormalities as well as alterations in the frequency of erythroblasts in circulating blood as biomarkers for genotoxicity and cytotoxicity, respectively. Swimming, growth, developmental and morphological abnormalities were also employed as sublethal end points. Results show that the species is within the 13th percentile of the distribution of acute sensitivity of species to pirimicarb for aquatic vertebrates...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28737097/elevated-levels-of-procalcitonin-and-interleukin-6-are-linked-with-postoperative-complications-in-cardiac-surgery
#11
A Brocca, G M Virzì, M de Cal, D Giavarina, M Carta, C Ronco
BACKGROUND: Cardiac surgery-associated acute kidney injury is a frequent and serious postoperative complication of cardiac surgery and is associated with an increased risk of morbidity, mortality, and length stay. In this study, we hypothesized that persistent elevation in inflammation in the first 48 h might be a powerful predictor of clinical outcome. Our aim was to elucidate the usefulness of interleukin-6 and procalcitonin postoperative levels in predicting mortality and renal complications in cardiac surgery patients...
March 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28693615/genome-analysis-of-clostridium-perfringens-isolates-from-healthy-and-necrotic-enteritis-infected-chickens-and-turkeys
#12
Troels Ronco, Marc Stegger, Kim Lee Ng, Berit Lilje, Ulrike Lyhs, Paal Skytt Andersen, Karl Pedersen
OBJECTIVE: Clostridium perfringens causes gastrointestinal diseases in both humans and domestic animals. Type A strains expressing the NetB toxin are the main cause of necrotic enteritis (NE) in chickens, which has remarkable impact on animal welfare and production economy in the international poultry industry. Three pathogenicity loci NELoc-1, -2 and -3 and a collagen adhesion gene cnaA have been found to be associated with NE in chickens, whereas the presence of these has not been investigated in diseased turkeys...
July 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28666938/death-of-adrenocortical-cells-during-murine-acute-t-cruzi-infection-is-not-associated-with-tnf-r1-signaling-but-mostly-with-the-type-ii-pathway-of-fas-mediated-apoptosis
#13
Ana R Pérez, Flavia Lambertucci, Florencia B González, Eduardo A Roggero, Oscar A Bottasso, Juliana de Meis, Maria T Ronco, Silvina R Villar
Earlier studies from our laboratory demonstrated that acute experimental Trypanosoma cruzi infection promotes an intense inflammation along with a sepsis-like dysregulated adrenal response characterized by normal levels of ACTH with raised glucocorticoid secretion. Inflammation was also known to result in adrenal cell apoptosis, which in turn may influence HPA axis uncoupling. To explore factors and pathways which may be involved in the apoptosis of adrenal cells, together with its impact on the functionality of the gland, we carried out a series of studies in mice lacking death receptors, such as TNF-R1 (C57BL/6-Tnfrsf1a tm1Imx or TNF-R1-/- ) or Fas ligand (C57BL/6 Fas-deficient lpr mice), undergoing acute T...
October 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28546061/primary-biliary-cholangitis-advances-in-management-and-treatment-of-the-disease
#14
Pietro Invernizzi, Annarosa Floreani, Marco Carbone, Marco Marzioni, Antonio Craxi, Luigi Muratori, Umberto Vespasiani Gentilucci, Ivan Gardini, Antonio Gasbarrini, Paola Kruger, Francesco Saverio Mennini, Virginia Ronco, Elena Lanati, Pier Luigi Canonico, Domenico Alvaro
Primary Biliary Cholangitis, previously known as Primary Biliary Cirrhosis, is a rare disease, which mainly affects women in their fifth to seventh decades of life. It is a chronic autoimmune disease characterized by a progressive damage of interlobular bile ducts leading to ductopenia, chronic cholestasis and bile acids retention. Even if the disease usually presents a long asymptomatic phase and a slow progression, in many patients it may progress faster toward cirrhosis and its complications. The 10year mortality is greater than in diseases such as human immunodeficiency virus/Hepatitis C Virus coinfection and breast cancer...
August 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28494980/extracorporeal-ultrafiltration-for-fluid-overload-in-heart-failure-current-status-and-prospects-for-further-research
#15
REVIEW
Maria Rosa Costanzo, Claudio Ronco, William T Abraham, Piergiuseppe Agostoni, Jonathan Barasch, Gregg C Fonarow, Stephen S Gottlieb, Brian E Jaski, Amir Kazory, Allison P Levin, Howard R Levin, Giancarlo Marenzi, Wilfried Mullens, Dan Negoianu, Margaret M Redfield, W H Wilson Tang, Jeffrey M Testani, Adriaan A Voors
More than 1 million heart failure hospitalizations occur annually, and congestion is the predominant cause. Rehospitalizations for recurrent congestion portend poor outcomes independently of age and renal function. Persistent congestion trumps serum creatinine increases in predicting adverse heart failure outcomes. No decongestive pharmacological therapy has reduced these harmful consequences. Simplified ultrafiltration devices permit fluid removal in lower-acuity hospital settings, but with conflicting results regarding safety and efficacy...
May 16, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28482261/nonvitamin-k-dependent-oral-anticoagulants-noacs-in-chronic-kidney-disease-patients-with-atrial-fibrillation
#16
REVIEW
L Di Lullo, C Ronco, M Cozzolino, D Russo, L Russo, B Di Iorio, A De Pascalis, V Barbera, M Galliani, E Vitaliano, C Campana, F Santoboni, A Bellasi
Atrial fibrillation (AF) represents the most common arrhythmia in patients with chronic kidney disease (CKD). As in the general population, in CKD patients AF is associated with an increased risk of thromboembolism and stroke. However, CKD patients, especially those on renal replacement therapy (RRT), also exhibit an increased risk of bleeding, especially from the gastrointestinal tract. Oral anticoagulation is the most effective form of thromboprophylaxis in patients with AF presenting increased risk of stroke...
July 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28460776/pathophysiology-of-the-cardio-renal-syndromes-types-1-5-an-uptodate
#17
REVIEW
L Di Lullo, A Bellasi, V Barbera, D Russo, L Russo, B Di Iorio, M Cozzolino, C Ronco
According to the recent definition proposed by the Consensus conference on Acute Dialysis Quality Initiative Group, the term cardio-renal syndrome (CRS) has been used to define different clinical conditions in which heart and kidney dysfunction overlap. Type 1 CRS (acute cardio- renal syndrome) is characterized by acute worsening of cardiac function leading to AKI (5, 6) in the setting of active cardiac disease such as ADHF, while type - 2 CRS occurs in a setting of chronic heart disease. Type 3 CRS is closely link to acute kidney injury (AKI), while type 4 represent cardiovascular involvement in chronic kidney disese (CKD) patients...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28408713/the-influence-of-glucose-exposure-load-and-peritoneal-membrane-transport-on-body-composition-and-nutritional-status-changes-after-1-year-on-peritoneal-dialysis
#18
Rafaela Siviero Caron-Lienert, Carlos Eduardo Poli-de-Figueiredo, Ana Elizabeth Prado Lima Figueiredo, Bartira Ercília Pinheiro da Costa, Carlo Crepaldi, Alessandra Campani Pizzato, Fiorenza Ferrari, Anna Giuliani, Claudio Ronco
BACKGROUND: The characteristics of peritoneal membrane transport differ among patients, affecting the prescription of peritoneal dialysis (PD) modality and glucose exposure in order to achieve an effective dialysis. This study aims to verify the influence of glucose exposure load and peritoneal membrane transport on body composition and nutritional status changes after the first year of PD. METHODS: We examined a cohort of 85 incident PD patients during the first year of treatment...
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28314581/a-proposal-for-standardized-grading-of-chronic-changes-in-native-kidney-biopsy-specimens
#19
Sanjeev Sethi, Vivette D D'Agati, Cynthia C Nast, Agnes B Fogo, An S De Vriese, Glen S Markowitz, Richard J Glassock, Fernando C Fervenza, Surya V Seshan, Andrew Rule, Lorraine C Racusen, Jai Radhakrishnan, Christopher G Winearls, Gerald B Appel, Ingeborg M Bajema, Anthony Chang, Robert B Colvin, H Terence Cook, Sundaram Hariharan, Loren P Herrera Hernandez, Neeraja Kambham, Michael Mengel, Karl A Nath, Helmut G Rennke, Pierre Ronco, Brad H Rovin, Mark Haas
Chronic changes represent an important component of native kidney biopsy evaluation and have a major bearing on predicting prognosis and guiding treatment. We propose here a uniform, semiquantitative approach to assessing such changes, which include glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis, and we report these findings as an overall chronicity grade.
April 2017: Kidney International
https://www.readbyqxmd.com/read/28255652/attenuation-of-liver-cancer-development-by-oral-glycerol-supplementation-in-the-rat
#20
Alejo M Capiglioni, Florencia Lorenzetti, Ariel D Quiroga, Juan P Parody, María T Ronco, Gerardo B Pisani, María C Carrillo, María P Ceballos, María de Luján Alvarez
PURPOSE: Glycerol usage is increasing in food industry for human and animal nutrition. This study analyzed the impact of glycerol metabolism when orally supplemented during the early stage of rat liver carcinogenesis. METHODS: Wistar rats were subjected to a 2-phase model of hepatocarcinogenesis (initiated-promoted, IP group). IP animals also received glycerol by gavage (200 mg/kg body weight, IPGly group). RESULTS: Glycerol treatment reduced the volume of preneoplastic lesions by decreasing the proliferative status of liver foci, increasing the expression of p53 and p21 proteins and reducing the expression of cyclin D1 and cyclin-dependent kinase 1...
March 2, 2017: European Journal of Nutrition
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