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https://www.readbyqxmd.com/read/27923836/the-swi-snf-complex-protein-snr1-is-a-tumor-suppressor-in-drosophila-imaginal-tissues
#1
Gengqiang Xie, Hanqing Chen, Dongyu Jia, Zhiqiang Shu, William Hunt Palmer, Yi-Chun Huang, Xiankun Zeng, Steven X Hou, Renjie Jiao, Wu-Min Deng
Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How SMARCB1/hSNF5 functions differently from other members of the SWI/SNF complex remains unclear. Here we use Drosophila imaginal epithelial tissues to demonstrate that Snr1, the conserved homolog of human SMARCB1/hSNF5, prevents tumorigenesis by maintaining normal endosomal trafficking-mediated signaling cascades...
December 6, 2016: Cancer Research
https://www.readbyqxmd.com/read/27923443/child-care-chaos-and-teachers-responsiveness-the-indirect-associations-through-teachers-emotion-regulation-and-coping
#2
Lieny Jeon, Eunhye Hur, Cynthia K Buettner
Teachers in early child-care settings are key contributors to children's development. However, the role of teachers' emotional abilities (i.e., emotion regulation and coping skills) and the role of teacher-perceived environmental chaos in relation to their responsiveness to children are understudied. The current study explored the direct and indirect associations between teachers' perceptions of child-care chaos and their self-reported contingent reactions towards children's negative emotions and challenging social interactions via teachers' emotional regulation and coping strategies...
December 2016: Journal of School Psychology
https://www.readbyqxmd.com/read/27923441/she-s-supporting-them-who-s-supporting-her-preschool-center-level-social-emotional-supports-and-teacher-well-being
#3
Katherine M Zinsser, Claire G Christensen, Luz Torres
Preschool teachers across the country have been charged to prepare children socially and emotionally for kindergarten. Teachers working in preschool centers are supporting children's social and emotional learning (SEL) within a rich ecology of emotion and social relationships and the present study considers how the supports implemented for children's SEL at the center-level are associated with teachers' psychological health and workplace experiences. Hierarchical linear models were constructed using data from the Head Start Family and Child Experiences Survey 2009 cohort...
December 2016: Journal of School Psychology
https://www.readbyqxmd.com/read/27923355/oral-health-related-quality-of-life-and-early-childhood-caries-among-preschool-children-in-trinidad
#4
Rahul Naidu, June Nunn, Erica Donnelly-Swift
BACKGROUND: Early childhood caries (ECC) is a public health problem in developed and developing countries. The purpose of this study was to describe the relationship between oral health-related quality of life (OHRQoL) and ECC among preschool children in a Caribbean population. METHOD: Parents/primary caregivers of children attending nine, randomly selected preschools in central Trinidad were invited to complete an oral health questionnaire and have their child undertake an oral examination...
December 7, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27923322/international-medallists-and-non-medallists-developmental-sport-activities-a-matched-pairs-analysis
#5
Arne Güllich
The study examined developmental participation patterns of international top athletes. Pairs of 83 international medallists (including 38 Olympic/World Champions) and 83 non-medallists were matched by sport, age and gender. A questionnaire recorded their volume of organised (coach-led) practice/training in their respective main sport and in other sports through childhood, adolescence and adulthood, and also involvement in non-organised (peer-led) sport activity. Analyses revealed that the medallists started practice/training in their main sport at an older age than non-medallists and accumulated slightly, but significantly less main-sport practice/training through childhood/adolescence...
December 6, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27923101/secular-changes-in-physical-growth-and-obesity-among-southwestern-american-indian-children-over-four-decades
#6
P Vijayakumar, K M Wheelock, S Kobes, R G Nelson, R L Hanson, W C Knowler, M Sinha
BACKGROUND AND OBJECTIVES: Most studies describing childhood obesity in the United States are based on cross-sectional surveys and do not include substantial numbers of American Indians (AI). Secular trends in height and weight reflect general health status. This study describes weight trends and transitions among AI children over a 43-year period. METHODS: Anthropometric data were obtained from a prospective study conducted in a southwestern US AI population (1965 through 2007)...
December 6, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27923099/cesarean-birth-is-not-associated-with-early-childhood-body-mass-index
#7
L G Smithers, B W Mol, L Jamieson, J W Lynch
Cesarean birth leads to a markedly different microbiome compared to vaginal birth, and the microbiome has been implicated in childhood obesity. Among mothers who had a previous cesarean, we compared anthropometry of 3- to 6-year-old children who were subsequently born by cesarean section versus vaginal birth. This large population-based study involved linking de-identified administrative perinatal and anthropometric data. Children's weight and height were collected at community-based clinics and converted to age- and sex-adjusted z-scores of height-for-age (HFAz), weight-for-age (WFAz) and BMI-for-age (BMIz)...
December 6, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27922496/metabolic-myopathies
#8
Mark A Tarnopolsky
PURPOSE OF REVIEW: Metabolic myopathies are genetic disorders that impair intermediary metabolism in skeletal muscle. Impairments in glycolysis/glycogenolysis (glycogen-storage disease), fatty acid transport and oxidation (fatty acid oxidation defects), and the mitochondrial respiratory chain (mitochondrial myopathies) represent the majority of known defects. The purpose of this review is to develop a diagnostic and treatment algorithm for the metabolic myopathies. RECENT FINDINGS: The metabolic myopathies can present in the neonatal and infant period as part of more systemic involvement with hypotonia, hypoglycemia, and encephalopathy; however, most cases present in childhood or in adulthood with exercise intolerance (often with rhabdomyolysis) and weakness...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27922488/intraoperative-assessment-of-facial-nerve-trunk-width-in-early-childhood-with-cervicofacial-lymphatic-malformation
#9
Ara Kim, Jeong-Meen Seo, So Young Lim
BACKGROUND: Facial nerve damage during head and neck surgery has long been an important issue. However, few publications on the gross anatomy of the facial nerve are available in the young population. The aim of this study was to provide in vivo measurements of the facial nerve trunk during lymphatic malformation (LM) resection and to determine the association between the trunk width and patient- and disease-related variables. METHODS: We conducted a retrospective analysis of 11 consecutive pediatric patients (11 facial nerve trunks) who underwent cervicofacial LM resection...
December 2, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27921445/risk-of-neonatal-and-childhood-morbidity-among-preterm-infants-exposed-to-marijuana
#10
Sarah K Dotters-Katz, Marcela C Smid, Tracy A Manuck, Torri D Metz
BACKGROUND: Limited data exist regarding the neonatal and neurodevelopmental outcomes of infants exposed to marijuana (MJ) in-utero, particularly among preterm infants. We hypothesized that MJ-exposed preterm infants would have worse neonatal and childhood developmental outcomes compared to MJ-unexposed infants. METHODS: Secondary analysis of multicenter randomized-controlled trial of antenatal magnesium sulfate for prevention of cerebral palsy was conducted. Singleton non-anomalous infants delivered <35 weeks exposed to MJ in-utero were compared to MJ-unexposed...
December 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27921422/-pregestional-diabetes-mellitus-and-pregnancy
#11
Jana Bělobrádková
There is a groving number of women with pregestational diabetes mellitus. Additionaly, nowadays therapy of diabetes mellitus type I allows gravidity even in patients in whom diabetes manifested itself during their early childhood. Presence of chronic complications of diabetes increases risk of complications during pregnancy. There is incerasing number of patients with DM type II and appearence of it shifts into younger age group. Perinatal mortality and morbidity of children of mothers with pregestional diabets is higher than in comparison with common population and pregnancy planning is important measure to their decrease...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921322/the-heterophoria-of-3-5-year-old-children-as-a-function-of-viewing-distance-and-target-type
#12
Mary E Troyer, Vidhyapriya Sreenivasan, T J Peper, T Rowan Candy
PURPOSE: Heterophoria is the misalignment of the eyes in monocular viewing and represents the accuracy of vergence driven by all classical cues except disparity. It is challenging to assess restless children using clinical cover tests, and phoria in early childhood is poorly understood. Here we used eye tracking to assess phoria as a function of viewing distance and target in adults and young children, with comparison to clinical cover tests. METHODS: Purkinje image tracking (MCS PowerRefractor) was used to record eye alignment in adults (19-28 years, N = 24) and typically developing children (3-5 years, N = 24)...
December 5, 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/27921287/differential-third-grade-outcomes-associated-with-attending-publicly-funded-preschool-programs-for-low-income-latino-children
#13
Arya Ansari, Michael Lόpez, Louis Manfra, Charles Bleiker, Laura H B Dinehart, Suzanne C Hartman, Adam Winsler
This study examined the third-grade outcomes of 11,902 low-income Latino children who experienced public school pre-K or child care via subsidies (center-based care) at age 4 in Miami-Dade County, Florida. Regression and propensity score analyses revealed that children who experienced public school pre-K earned higher scores on standardized assessments of math and reading in third grade and had higher grade point averages than those who attended center-based care 4 years earlier. The sustained associations between public school pre-K (vs...
December 6, 2016: Child Development
https://www.readbyqxmd.com/read/27920351/effects-of-pediatric-anticipatory-guidance-on-mothers-of-young-children
#14
Hui-Chin Hsu, Shih-Yu Lee, Chin-Man Lai, Wan-Ling Tsai, Hsiao-Tung Chiu
Provision of anticipatory guidance to parents during well-child visits is a defining component of pediatric primary care. Using nationally representative data from the 2000 U.S. National Survey of Early Childhood Health, this study addressed the questions of whether, how, and what mothers of children below age 3 with different ethnic/racial background could benefit from anticipatory guidance. Structural equation modeling results showed that across ethnic/racial groups, guidance was directly associated with decreased maternal stress and directly and indirectly associated with effective parenting practices in child development, discipline, and safety...
December 5, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27920313/previous-medicaid-expansion-may-have-had-lasting-positive-effects-on-oral-health-of-non-hispanic-black-children
#15
Brandy J Lipton, Laura R Wherry, Sarah Miller, Genevieve M Kenney, Sandra Decker
Healthy tooth development starts early in life, beginning even before birth. We present new evidence suggesting that a historic public health insurance expansion for pregnant women and children in the United States in the 1980s and 1990s may have had long-lasting effects on the oral health of the children gaining eligibility. We estimated the relationship between adult oral health and the extent of state public health insurance eligibility for pregnant women, infants, and children throughout childhood separately for non-Hispanic whites, non-Hispanic blacks, and Hispanics...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27919542/total-hdl-cholesterol-efflux-capacity-in-healthy-children-associations-with-adiposity-and-dietary-intakes-of-mother-and-child
#16
H Khalil, C Murrin, M O'Reilly, K Viljoen, R Segurado, J O'Brien, R Somerville, F McGillicuddy, C C Kelleher
BACKGROUND AND AIMS: High-density lipoprotein (HDL) cholesterol efflux capacity in adults may be a measure of the atheroprotective property of HDL. Little however, is known about HDL cholesterol efflux capacity in childhood. We aimed to investigate the relationship between HDL cholesterol efflux capacity and childhood anthropometrics in a longitudinal study. METHODS AND RESULTS: Seventy-five children (mean age = 9.4 ± 0.4 years) were followed from birth until the age of 9 years...
October 12, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27918695/sedentary-time-physical-activity-and-executive-function-in-a-longitudinal-study-of-youth
#17
Erick E Wickel
BACKGROUND: This study examined associations between sedentary time, physical activity (PA), and executive function among youth participating in the Study of Early Child Care and Youth Development. METHODS: >: Sedentary time and PA (light, moderate, vigorous, and moderate-to-vigorous (MVPA)) were objectively assessed at 9 and 15 yrs, while executive function (inhibition, working memory, and fluid intelligence) were assessed at 15 yrs. Regression models were used to examine associations...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27917589/the-petale-study-late-adverse-effects-and-biomarkers-in-childhood-acute-lymphoblastic-leukemia-survivors
#18
Sophie Marcoux, Simon Drouin, Caroline Laverdière, Nathalie Alos, Gregor U Andelfinger, Laurence Bertout, Daniel Curnier, Matthias G Friedrich, Ekaterini A Kritikou, Geneviève Lefebvre, Emile Levy, Sarah Lippé, Valérie Marcil, Marie-Josée Raboisson, Frank Rauch, Philippe Robaey, Mariia Samoilenko, Chantal Séguin, Serge Sultan, Maja Krajinovic, Daniel Sinnett
BACKGROUND: Childhood cancer survivorship issues represent an established public health challenge. Most late adverse effects (LAEs) have been demonstrated to be time and treatment dependent. The PETALE study is a multidisciplinary research project aiming to comprehensively characterize LAEs and identify associated predictive biomarkers in childhood acute lymphoblastic leukemia (cALL) survivors. METHODS: cALL survivors treated at Sainte-Justine University Health Center with Dana-Farber Cancer Institution-ALL protocols 87-01 through 2005-01 were eligible...
December 4, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27917475/tipping-points-curvilinear-associations-between-activity-level-and-mental-development-in-toddlers
#19
Megan Flom, Madeleine Cohen, Kimberly J Saudino
BACKGROUND: The Theory of Optimal Stimulation (Zentall & Zentall, Psychological Bulletin, 94, 1983, 446) posits that the relation between activity level (AL) and cognitive performance follows an inverted U shape where midrange AL predicts better cognitive performance than AL at the extremes. METHODS: We explored this by fitting linear and quadratic models predicting mental development from AL assessed via multiple methods (parent ratings, observations, and actigraphs) and across multiple situations (laboratory play, laboratory test, home) in over 600 twins (2- and 3-year olds)...
December 5, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27917472/observed-fearlessness-and-positive-parenting-interact-to-predict-childhood-callous-unemotional-behaviors-among-low-income-boys
#20
Rebecca Waller, Daniel S Shaw, Luke W Hyde
BACKGROUND: Callous-unemotional behaviors identify children at risk for severe and chronic antisocial behavior. Research is needed to establish pathways from temperament and parenting factors that give rise to callous-unemotional behaviors, including interactions of positive versus harsh parenting with child fearlessness. METHODS: Multimethod data, including parent reports and observations of parent and child behavior, were drawn from a prospective, longitudinal sample of low-income boys (N = 310) with assessments at 18, 24, and 42 months, and at ages 10-12 years old...
December 5, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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