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https://www.readbyqxmd.com/read/28938412/renal-metabolic-programming-is-linked-to-the-dynamic-regulation-of-a-leptin-klf15-axis-and-akt-ampk%C3%AE-signaling-in-male-offspring-of-obese-dams
#1
Philipp Kasper, Christina Vohlen, Katharina Dinger, Jasmine Mohr, Eva Hucklenbruch-Rother, Ruth Janoschek, Jessica Köth, Jan Matthes, Sarah Appel, Jörg Dötsch, Miguel A Alejandre Alcazar
Childhood obesity is associated with renal diseases. Maternal obesity is a risk factor linked to increased adipocytokines and metabolic disorders in the offspring. We therefore studied the impact of maternal obesity on renal-intrinsic insulin and adipocytokine signaling and on renal function and structure. To induce maternal obesity female mice were fed with high-fat diet (HFD) or standard diet (SD, Co) prior to mating, during gestation and throughout lactation. A third group of dams was fed HFD only during lactation (HFD-Lac)...
July 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938322/the-relationship-of-the-temporal-branch-of-the-facial-nerve-to-the-fascial-planes-of-temporal-region-in-human-fetuses
#2
Özlem Elvan, Alev Bobuş Kara, Mesut Sabri Tezer, Mustafa Aktekin
The aim of this study was to obtain information by assessing the relationship between temporal region fascial structures, fat pads, and temporal branches of facial nerve in human fetuses to use the knowledge on treatment of early childhood period surgeries. This anatomic dissection study was conducted on 40 hemifaces with no visible external abnormalities on their faces. Fascial layers and related fat pads of temporal region were dissected layer by layer beginning from superficial to deep. The relations of temporal branches of facial nerve and temporoparietal fascia and the structures of these fascial layers were evaluated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28937904/periodontal-pathogen-colonization-in-young-children-by-pcr-quantification-a-longitudinal-survey
#3
Karine Takahashi, Robson Frederico Cunha, Elerson Gaetti Jardim Junior
INTRODUCTION: Periodontal diseases are among the leading causes of premature tooth loss in adults, but the microbiota associated with this problem is established over time in childhood. AIM: This longitudinal study aimed to verify the occurrence of periodontal pathogens in the oral cavity of children aged six, twelve, eighteen and twenty-four months through PCR quantification, correlating them with the oral microbiota of their mothers. STUDY DESIGN: Saliva and oral biofilm samples were collected from mothers and children by using sterilized paper points...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937896/evaluation-of-oral-health-related-quality-of-life-to-assess-dental-treatment-in-preschool-children-with-early-childhood-caries-a-preliminary-study
#4
Ana Lúcia Vollú, Maria da Encarnação Perez Requejo da Costa, Lucianne Cople Maia, Andréa Fonseca-Gonçalves
PURPOSE: The oral health-related quality of life (OHRQoL) of preschool children with Early Childhood Caries (ECC) was used to assess the outcome of dental treatment. STUDY DESIGN: Children (3.56±1.31years) affected by ECC were selected. Anamnesis, clinical and radiographic exams were performed. Data about sociodemographic aspects, OHRQoL and dmf-t index were collected. The Brazilian version of Early Childhood Oral health Impact Scale (B-ECOHIS) was applied in two time intervals: before and after 30 days of treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937639/sleep-disorders-in-childhood-neurological-diseases
#5
REVIEW
Abdullah Tolaymat, Zhao Liu
Sleep problems are frequently addressed as a primary or secondary concern during the visit to the pediatric neurology clinic. Sleep disorders can mimic other neurologic diseases (e.g., epilepsy and movement disorders), and this adds challenges to the diagnostic process. Sleep disorders can significantly affect the quality of life and functionality of children in general and those with comorbid neurological diseases in particular. Understanding the pathophysiology of sleep disorders, recognizing the implications of sleep disorder in children with neurologic diseases and behavioral difficulties, and early intervention continue to evolve resulting in better neurocognitive outcomes...
September 22, 2017: Children
https://www.readbyqxmd.com/read/28937552/naspghan-clinical-report-on-postoperative-recurrence-in-pediatric-crohn-disease
#6
Judy B Splawski, Marian D Pffefferkorn, Marc E Schaefer, Andrew S Day, Oliver S Soldes, Todd A Ponsky, Philip Stein, Jess L Kaplan, Shehzad A Saeed
Pediatric Crohn disease is characterized by clinical and endoscopic relapses. The inflammatory process is considered to be progressive and may lead to strictures, fistulas, and penetrating disease that may require surgery. In addition, medically refractory disease may be treated by surgical resection of inflamed bowel in an effort to reverse growth failure. The need for surgery in childhood suggests severe disease and these patients have an increased risk for recurrent disease and potentially more surgery. Data show that up to 55% of patients had clinical recurrence in the first 2 years after initial surgery...
October 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28937467/does-the-prevalence-of-spondylolysis-and-spina-bifida-occulta-observed-in-pediatric-patients-remain-stable-in-adults
#7
Julio Urrutia, Tomas Zamora, Jorge Cuellar
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To compare the prevalence of lumbar spondylolysis and spina bifida occulta (SBO) in pediatric and adult populations. SUMMARY OF BACKGROUND DATA: The prevalence of spondylolysis reported from radiograph-based studies in children had been questioned in computed tomography (CT)-based studies in adults; however, a recent CT-based study in pediatric patients has confirmed the previously reported data in pediatric populations...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937451/cognitive-and-psychosocial-functioning-of-preschool-aged-children-with-cancer
#8
Victoria W Willard, Lauren E Cox, Kathryn M Russell, Ansley Kenney, Niki Jurbergs, Andrew E Molnar, Jennifer L Harman
OBJECTIVE: Most children with cancer are diagnosed in early childhood, potentially resulting in missed developmental opportunities. The most common diagnoses-brain tumors, leukemia-are also associated with increased risk of neurocognitive deficits. Unfortunately, research regarding the functioning of preschool-aged children with cancer is limited. Our objective is to describe the cognitive and psychosocial functioning of preschool-aged children with cancer who completed a clinical evaluation at a hospital-based psychology clinic...
September 19, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28937417/age-related-changes-in-ocular-aberrations-and-the-yamagata-study-funagata
#9
Hiroyuki Namba, Ryo Kawasaki, Akira Sugano, Takanori Murakami, Koichi Nishitsuka, Takeo Kato, Takamasa Kayama, Hidetoshi Yamashita
Human vision quality is influenced by ocular aberrations, including astigmatism and higher-order aberrations (HOAs), in combination with other optical factors. In this study, we introduce the results and perceptions of previous studies investigating these aberrations. We also introduce our results obtained as part of the Yamagata Study (Funagata), a population-based epidemiologic study. To investigate the astigmatic change with age, researchers have used the power vector analysis, allowing incorporation of the magnitude and axis of astigmatism into statistical analyses...
September 19, 2017: Cornea
https://www.readbyqxmd.com/read/28936803/independent-contributions-of-early-positive-parenting-and-mother-son-coercion-on-emerging-social-development
#10
Berna Akcinar, Daniel S Shaw
In the current study, we explored associations between parent-child coercion and positive parenting in the toddler period in relation to children's social-behavioral development during the school-age period. The data were drawn from the Pitt Mother & Child Project, a sample of 310 low-income, ethnically diverse boys. Drawing on tenets of both attachment and social learning theory, it was hypothesized that coercive mother-son interaction would lead to reductions in positive maternal parenting in the toddler period, and that both positive parenting and mother-son coercion in the toddler period would contribute to children's conduct problems at school entry and lower social skills and peer rejection in middle childhood...
September 21, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28936797/peer-victimization-and-adjustment-in-young-adulthood-introduction-to-the-special-section
#11
Mara Brendgen
A substantive number of children and adolescents are bullied by their peers, with serious risks for the victims' emotional, behavioral, physical, and academic adjustment. However, while the immediate and short-term consequences of peer victimization in childhood and adolescence are very well documented, knowledge about the potential long-term consequences for victims' functioning once they reach adulthood is only slowly emerging. Based on prospective, longitudinal data from different countries, the 4 papers in this special section investigate the association between peer victimization suffered in childhood and adolescence and victims' developmental outcomes in late adolescence/early adulthood...
September 22, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28936391/evaluation-of-a-multi-year-policy-focused-intervention-to-increase-physical-activity-and-related-behaviors-in-lower-resourced-early-care-and-education-settings-active-early-2-0
#12
Emily J Tomayko, Ronald J Prince, Jill Hoiting, Abbe Braun, Tara L LaRowe, Alexandra K Adams
Physical activity is a critical component of obesity prevention, but few interventions targeting early childhood have been described. The Active Early guide was designed to increase physical activity in early care and education (ECE) settings. The purpose of Active Early 2.0 was to evaluate the effectiveness of Active Early along with provider training, microgrant support, and technical assistance over 2 years (2012-2014) to increase physical activity and related behaviors (e.g., nutrition) in settings serving a high proportion of children from underserved groups in recognition of significant disparities in obesity and challenges meeting physical activity recommendations in low-resource settings...
December 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28936358/characteristics-of-occupational-musculoskeletal-disorders-of-five-sectors-in-service-industry-between-2004-and-2013
#13
Hyun-Woo Choi, Young-Ki Kim, Dong-Mug Kang, Jong-Eun Kim, Bo-Young Jang
BACKGROUND: 'Work related musculoskeletal disorders (WRMSDs)' have been mostly reported in the manufacturing industry but recently the occurrence of industrial injuries has been constantly increasing in the service industry. This research is going to analyze the data about workers' compensation for WRMSDs in five different service sectors and identify characteristics of occupations with the highest approved occupations. METHODS: According to the data released from the Korea Worker's Compensation & Welfare Service, the overview of 12,730 cases of workers' compensation for WRMSDs in five service sectors from 2004 to 2013 is going to be analyzed and the source data is going to be classified by the Korean Standard Classification of Occupations to select the top five occupations that have the highest number of approval...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28936126/attention-to-threat-as-a-predictor-of-shyness-in-the-context-of-internalizing-and-externalizing-problems
#14
Alexandra C Hummel, Julie E Premo, Elizabeth J Kiel
The duration of children's attention to putative threat has been documented as a consistent predictor of later anxiety in inhibited children across childhood (Fox, 2010; Perez-Edgar & Fox, 2005). However, attention to threat has not been broadly examined within existing behavioral contexts, and has seldom been studied in very early childhood. Whereas toddlers with high levels of internalizing behavior may view fear-inducing stimuli as a threat, toddlers with high levels of externalizing behavior may demonstrate attention out of interest or sensation seeking...
March 2017: Infancy: the Official Journal of the International Society on Infant Studies
https://www.readbyqxmd.com/read/28935662/adult-disinhibited-social-engagement-in-adoptees-exposed-to-extreme-institutional-deprivation-examination-of-its-clinical-status-and-functional-impact
#15
Mark Kennedy, Jana Kreppner, Nicky Knights, Robert Kumsta, Barbara Maughan, Dennis Golm, Jonathan Hill, Michael Rutter, Wolff Schlotz, Edmund Sonuga-Barke
BackgroundEarly-life institutional deprivation produces disinhibited social engagement (DSE). Portrayed as a childhood condition, little is known about the persistence of DSE-type behaviours into, presentation during, and their impact on, functioning in adulthood.AimsWe examine these issues in the young adult follow-up of the English and Romanian Adoptees study.MethodA total of 122 of the original 165 Romanian adoptees who had spent up to 43 months as children in Ceauşescu's Romanian orphanages and 42 UK adoptees were assessed for DSE behaviours, neurodevelopmental and mental health problems, and impairment between ages 2 and 25 years...
September 21, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28935660/childhood-adversities-and-post-traumatic-stress-disorder-evidence-for-stress-sensitisation-in-the-world-mental-health-surveys
#16
Katie A McLaughlin, Karestan C Koenen, Evelyn J Bromet, Elie G Karam, Howard Liu, Maria Petukhova, Ayelet Meron Ruscio, Nancy A Sampson, Dan J Stein, Sergio Aguilar-Gaxiola, Jordi Alonso, Guilherme Borges, Koen Demyttenaere, Rumyana V Dinolova, Finola Ferry, Silvia Florescu, Giovanni de Girolamo, Oye Gureje, Norito Kawakami, Sing Lee, Fernando Navarro-Mateu, Marina Piazza, Beth-Ellen Pennell, José Posada-Villa, Margreet Ten Have, Maria Carmen Viana, Ronald C Kessler
BackgroundAlthough childhood adversities are known to predict increased risk of post-traumatic stress disorder (PTSD) after traumatic experiences, it is unclear whether this association varies by childhood adversity or traumatic experience types or by age.AimsTo examine variation in associations of childhood adversities with PTSD according to childhood adversity types, traumatic experience types and life-course stage.MethodEpidemiological data were analysed from the World Mental Health Surveys (n = 27 017)...
September 21, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28935615/early-life-phthalate-exposure-and-adiposity-at-8-years-of-age
#17
Jessica Shoaff, George D Papandonatos, Antonia M Calafat, Xiaoyun Ye, Aimin Chen, Bruce P Lanphear, Kimberly Yolton, Joseph M Braun
BACKGROUND: Early-life phthalate exposure may influence child adiposity, but prior studies have not determined if there are periods of enhanced vulnerability to phthalates. OBJECTIVE: To examine the relationship between child adiposity at 8 y of age and repeated urinary biomarkers of phthalate exposure from gestation through childhood to determine if there are distinct periods of vulnerability. METHODS: In 219 mother-child pairs from Cincinnati, Ohio, we quantified nine urinary phthalate metabolites up to two times prenatally and six times from 1-8 y of age...
September 11, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28935462/insulin-resistance-serum-uric-acid-and-metabolic-syndrome-are-linked-to-cardiovascular-dysfunction-in-pediatric-obesity
#18
Giulia Genoni, Veronica Menegon, Gioel Gabrio Secco, Michela Sonzini, Massimiliano Martelli, Matteo Castagno, Roberta Ricotti, Alice Monzani, Michele Aronici, Elena Grossini, Carlo Di Mario, Gianni Bona, Simonetta Bellone, Flavia Prodam
INTRODUCTION: Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations. AIM: Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS)...
September 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28934725/prenatal-exposure-to-mercury-associations-with-global-dna-methylation-and-hydroxymethylation-in-cord-blood-and-in-childhood
#19
Andres Cardenas, Sheryl L Rifas-Shiman, Lode Godderis, Radu-Corneliu Duca, Ana Navas-Acien, Augusto A Litonjua, Dawn L DeMeo, Kasey J Brennan, Chitra J Amarasiriwardena, Marie-France Hivert, Matthew W Gillman, Emily Oken, Andrea A Baccarelli
BACKGROUND: Mercury is a global pollutant, and prenatal exposure is associated with adverse health effects. To date, no studies have evaluated the association between prenatal mercury exposure and DNA hydroxymethylation, an epigenetic modification important for tissue differentiation and embryonic development. OBJECTIVES: We sought to evaluate the association between prenatal mercury exposure and offspring global DNA methylation and hydroxymethylation at birth and test for persistence of the association in childhood...
August 29, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934213/sports-engagement-and-age-at-first-myocardial-infarction-in-men-under-55-years-of-age
#20
Christoph Janggen, Christoph Gräni, Jonas Brunner, Lukas D Trachsel, Stephan Windecker, Prisca Eser, Lorenz Räber, Matthias Wilhelm
OBJECTIVE: Low levels of physical activity in childhood are associated with clustering of cardiovascular risk factors (CVRF) as predisposition for atherosclerosis. We assessed the association between sports engagement and age at first myocardial infarction (MI) in a cohort of men under 55 years of age. METHODS: The Bern percutaneous coronary intervention Registry (NCT 02241291) was analyzed from March 2009 until January 2012. Male patients with first MI, age 18 to 54 years and body mass index ≤25kg/m2 were included...
2017: PloS One
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