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https://www.readbyqxmd.com/read/28829900/analysis-of-p53-gene-polymorphism-codon-72-in-symptomatic-patients-with-atherosclerosis
#1
M H Lagares, K S F Silva, A M Barbosa, D A Rodrigues, I R Costa, J V M Martins, M P Morais, F L Campedelli, K K V O Moura
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or even leading to obstruction of other vessels with a smaller diameter. This process is one of the main determinants of the clinical manifestations of atherosclerosis, such as coronary artery disease, ischemic stroke, and peripheral arterial disease...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829826/elevated-neutrophil-to-lymphocyte-ratio-and-ischemic-stroke-risk-in-generally-healthy-adults
#2
Beomseok Suh, Dong Wook Shin, Hyung-Min Kwon, Jae Moon Yun, Hyung-Kook Yang, Eunmi Ahn, Hyejin Lee, Jin Ho Park, BeLong Cho
Elevated neutrophil to lymphocyte ratio (NLR) has been reported as a marker for chronic inflammation, associated with poor prognosis in ischemic stroke patients, but there has been no study that investigated its association with ischemic stroke risk. This study was conducted to investigate elevated NLR as an independent risk factor for ischemic stroke incidence. Our retrospective cohort study included 24,708 generally healthy subjects aged 30-75 who received self-referred health screening at Seoul National University Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28829679/abstracts-of-the-27th-annual-scientific-meeting-of-the-stroke-society-of-australasia-23-25-august-2017-queenstown-new-zealand
#3
(no author information available yet)
No abstract text is available yet for this article.
August 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28829350/pathophysiology-and-neuroprotective-strategies-in-hypoxic-ischemic-brain-injury-and-stroke
#4
EDITORIAL
Bruno P Meloni
Hypoxic-ischemic brain injury and stroke are closely related and devastating conditions that can affect individuals of all ages.[...].
August 22, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28829217/atlas-registration-for-edema-corrected-mri-lesion-volume-in-mouse-stroke-models
#5
Stefan Koch, Susanne Mueller, Marco Foddis, Thomas Bienert, Dominik von Elverfeldt, Felix Knab, Tracy D Farr, René Bernard, Monika Dopatka, André Rex, Ulrich Dirnagl, Christoph Harms, Philipp Boehm-Sturm
Lesion volume measurements with magnetic resonance imaging are widely used to assess outcome in rodent models of stroke. In this study, we improved a mathematical framework to correct lesion size for edema which is based on manual delineation of the lesion and hemispheres. Furthermore, a novel MATLAB toolbox to register mouse brain MR images to the Allen brain atlas is presented. Its capability to calculate edema-corrected lesion size was compared to the manual approach. Automated image registration performed equally well in in a mouse middle cerebral artery occlusion model (Pearson r = 0...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28829216/leukoaraiosis-as-an-outcome-predictor-in-the-acute-and-subacute-phases-of-stroke
#6
Fabio Fierini, Anna Poggesi, Leonardo Pantoni
Leukoaraiosis (LA) is one of the neuroimaging features of cerebral small vessel disease and is associated with poor long-term prognosis. Areas covered: This narrative review focuses on the predictive role of LA on the evolution of the ischemic brain damage and on the clinical outcome in the subacute phase of stroke and in the short-term period afterwards. Expert commentary: In acute stroke, LA is associated with a less favorable fate of brain infarct and is a marker of increased risk of thrombolysis-related hemorrhagic transformation...
August 22, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28829209/the-effect-of-sglt2-inhibitors-on-cardiovascular-events-and-renal-function
#7
Konstantinos P Imprialos, Konstantinos Stavropoulos, Michael Doumas, Asterios Karagiannis, Vasilios G Athyros
Introduction Sodium-glucose co-transporters-2inhibitors have emerged as a very promising antidiabetic drug class, with data from the two available cardiovascular trials of this class suggesting remarkable benefits in terms of cardiovascular events, total mortality and renal outcomes. Areas covered Data point toward clinically meaningful benefits from SGLT-2inhibition on a variety of cardiovascular risk factors. Empagliflozin, and to a lesser extent canagliflozin, resulted in significant reductions of an abundance of cardiovascular mortality and morbidity endpoints...
August 22, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28829203/gender-related-issues-in-thrombosis-and-hemostasis
#8
Anne-Mette Hvas, Emmanuel J Favaloro
Many aspects of hemostasis, both primary and secondary, as well as fibrinolysis display sex differences. From a clinical viewpoint, certain differential phenotypic presentations clearly arise within various disorders of thrombosis and hemostasis. Areas Covered: The present mini-review summarizes selected clinical entities where sex differences are reflected in both frequency and clinical presentation of hemostasis disorders. Sex differences are discussed within the settings of cardiovascular disease, including coronary artery disease and ischemic stroke, venous thromboembolism and inherited bleeding disorders...
August 22, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28828964/clinical-nutrition-and-gastrointestinal-dysfunction-in-critically-ill-stroke-patients
#9
Robert Patejdl, Matthias Kästner, Stephan Kolbaske, Matthias Wittstock
Background Data on the epidemiology and risk factors of altered gastrointestinal motility (AGIM) is virtually lacking for patients suffering from non-traumatic neurologic diseases and stroke. This study investigated whether patterns of AGIM differ between patients with stroke and other severe acute brain diseases. Methods Clinical records of stroke and non-stroke patients treated at a neurological intensive care unit (ICU) were reviewed at day 1-5 and at day 10 after admission. The data was analyzed for the course of enteral/parenteral nutrition and for and for signs and symptoms of gastrointestinal dysfunction...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28828931/post-stroke-depression-different-characteristics-based-on-follow-up-stage-and-gender-a-cohort-perspective-study-from-mainland-china
#10
Zixuan Wang, Meifang Zhu, Zhaoping Su, Boyuan Guan, Anxin Wang, Yongjun Wang, Ning Zhang, Chunxue Wang
BACKGROUND: Post-stroke depression (PSD) is a common and important comorbidity in patients after stroke. It negatively impacts stroke survivors' outcomes. Plenty of studies have investigated risk factors for PSD, especially sex differences. However, the results remain inconsistent. In this study, we explored the prevalence and risk factors for PSD both in the acute phase and the chronic phase of stroke, emphasizing on the impact of gender in PSD. METHODS: About 1094 patients with first-ever ischemic stroke were included in the study...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28828929/prognostic-value-of-serum-thioredoxin-levels-in-ischemic-stroke
#11
Tieer Yu, Wanli Zhang, Yuanshao Lin, Qian Li, Jie Xue, Zhengyi Cai, Yifan Cheng, Bei Shao
OBJECTIVES: Thioredoxin (Trx) is one of significant antioxidative molecules to diminish oxidative stress. Current evidence suggests that Trx is a potent antioxidant with cytoprotective functions. The aim of our study was to investigate specifically the association between serum Trx levels and acute ischemic stroke (AIS) patients. METHODS: 198 AIS patients and 75 controls were enrolled to the study. Serum Trx levels were measured using an enzyme-linked immunosorbent assay (ELISA)...
August 22, 2017: Neurological Research
https://www.readbyqxmd.com/read/28828633/effects-of-dimeric-psd-95-inhibition-on-excitotoxic-cell-death-and-outcome-after-controlled-cortical-impact-in-rats
#12
Jens Bak Sommer, Anders Bach, Hana Malá, Mikko Gynther, Ann-Sofie Bjerre, Marie Gajhede Gram, Linda Marschner, Kristian Strømgaard, Jesper Mogensen, Darryl S Pickering
Therapeutic effects of PSD-95 inhibition have been demonstrated in numerous studies of stroke; however only few studies have assessed the effects of PSD-95 inhibitors in traumatic brain injury (TBI). As the pathophysiology of TBI partially overlaps with that of stroke, PSD-95 inhibition may also be an effective therapeutic strategy in TBI. The objectives of the present study were to assess the effects of a dimeric inhibitor of PSD-95, UCCB01-144, on excitotoxic cell death in vitro and outcome after experimental TBI in rats in vivo...
August 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28828609/glial-gaba-transporters-as-modulators-of-inhibitory-signalling-in-epilepsy-and-stroke
#13
Maria E K Lie, Anas Al-Khawaja, Maria Damgaard, Anne S Haugaard, Arne Schousboe, Andrew N Clarkson, Petrine Wellendorph
Imbalances in GABA-mediated tonic inhibition are involved in several pathophysiological conditions. A classical way of controlling tonic inhibition is through pharmacological intervention with extrasynaptic GABAA receptors that sense ambient GABA and mediate a persistent GABAergic conductance. An increase in tonic inhibition may, however, also be obtained indirectly by inhibiting glial GABA transporters (GATs). These are sodium-coupled membrane transport proteins that normally act to terminate GABA neurotransmitter action by taking up GABA into surrounding astrocytes...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28828606/glycine-transporters-and-its-coupling-with-nmda-receptors
#14
Francisco Zafra, Ignacio Ibáñez, David Bartolomé-Martín, Dolores Piniella, Marina Arribas-Blázquez, Cecilio Giménez
Glycine plays two roles in neurotransmission. In caudal areas like the spinal cord and the brainstem, it acts as an inhibitory neurotransmitter, but in all regions of the CNS, it also works as a co-agonist with L-glutamate at N-methyl-D-aspartate receptors (NMDARs). The glycine fluxes in the CNS are regulated by two specific transporters for glycine, GlyT1 and GlyT2, perhaps with the cooperation of diverse neutral amino acid transporters like Asc-1 or SNAT5/SN2. While GlyT2 and Asc-1 are neuronal proteins, GlyT1 and SNAT5 are mainly astrocytic, although neuronal forms of GlyT1 also exist...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28828467/longitudinal-care-for-young-adults-with-stroke
#15
Lester Y Leung, Emiliya Melkumova, David E Thaler
No abstract text is available yet for this article.
August 21, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28828466/presenting-to-primary-stroke-centers-or-comprehensive-stroke-centers-for-thrombolysis
#16
Ken Uchino
No abstract text is available yet for this article.
August 21, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28828465/association-of-childhood-body-mass-index-and-change-in-body-mass-index-with-first-adult-ischemic-stroke
#17
Line K Gjærde, Michael Gamborg, Lars Ängquist, Thomas C Truelsen, Thorkild I A Sørensen, Jennifer L Baker
Importance: The incidence of ischemic stroke among young adults is rising and is potentially due to an increase in stroke risk factors occurring at younger ages, such as obesity. Objectives: To investigate whether childhood body mass index (BMI) and change in BMI are associated with adult ischemic stroke and to assess whether the associations are age dependent or influenced by birth weight. Design, Setting, and Participants: This investigation was a population-based cohort study of schoolchildren born from 1930 to 1987, with follow-up through national health registers from 1977 to 2012 in Denmark...
August 21, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28828462/presenting-to-primary-stroke-centers-or-comprehensive-stroke-centers-for-thrombolysis-reply
#18
Gaspard Gerschenfeld, Sonia Alamowitch
No abstract text is available yet for this article.
August 21, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28828213/human-urinary-kallidinogenase-promotes-good-recovery-in-ischemic-stroke-patients-with-level-3-hypertension
#19
Danhong Wu, Yi Lyu, Ping Zhong, Fengdi Liu, Xueyuan Liu
AIM: To evaluate the clinical efficacy of Human Urinary kallidinogenase (HUK) in the treatment of acute ischemic stroke (AIS) patients with level 3 hypertension. METHODS: In this retrospective study, from January 2015 to June 2016, 150 consecutive AIS patients were registered in our database. Among them, 47 with level 3 hypertension received either HUK treatment (HUK group, 22 cases) or basic treatment (control group, 25 cases). Basic treatment was administrated on all patients...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828211/duplex-ultrasonography-for-the-detection-of-vertebral-artery-stenosis-a-comparison-with-ct-angiography
#20
Anouk D Rozeman, Hajo Hund, Michel Westein, Marieke J H Wermer, Geert J Lycklama À Nijeholt, Jelis Boiten, Robert-Jan Schimsheimer, Ale Algra
OBJECTIVES: Vertebrobasilar stenosis is frequent in patients with posterior circulation stroke and it increases risk of recurrence. We investigated feasibility of duplex ultrasonography (DUS) for screening for extracranial vertebral artery stenosis and compared it with CT angiography (CTA). MATERIALS AND METHODS: We gathered data on 337 consecutive patients who had DUS because of posterior circulation stroke or TIA. Matching CTA studies were retrieved and used as reference...
August 2017: Brain and Behavior
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