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https://www.readbyqxmd.com/read/29471572/-cardiovascular-medication-in-elderly-patients
#1
Robert H G Schwinger
Elderly people show increased probability to develop atherosclerotic diseases; in consequence heart failure - most often following coronary heart disease - as well as atrial fibrillation is more common. Following guidelines may lead to polypharmacy, i. e. use of more than 5 drugs daily. Thus, drug interactions as well as side effects become more likely; especially in elderly patients reduced kidney function has to be taken into account. Only drugs which have shown to prolong life or to reduce symptoms in controlled clinical trials should be used...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471047/a-urinary-biosignature-for-mitochondrial-myopathy-encephalopathy-lactic-acidosis-and-stroke-like-episodes-melas
#2
Karien Esterhuizen, J Zander Lindeque, Shayne Mason, Francois H van der Westhuizen, Anu Suomalainen, Anna H Hakonen, Christopher J Carroll, Richard J Rodenburg, Paul B de Laat, Mirian C H Janssen, Jan A M Smeitink, Roan Louw
We used a comprehensive metabolomics approach to study the altered urinary metabolome of two mitochondrial myopathy, encephalopathy lactic acidosis and stroke like episodes (MELAS) cohorts carrying the m.3243A>G mutation. The first cohort were used in an exploratory phase, identifying 36 metabolites that were significantly perturbed by the disease. During the second phase, the 36 selected metabolites were able to separate a validation cohort of MELAS patients completely from their respective control group, suggesting usefulness of these 36 markers as a diagnostic set...
February 19, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29470997/predictors-of-favorable-outcome-after-mechanical-thrombectomy-for-anterior-circulation-acute-ischemic-stroke-in-octogenarians
#3
Matthias Barral, Louis Lassalle, Cyril Dargazanli, Mikael Mazighi, Hocine Redjem, Raphael Blanc, Georges Rodesch, Bertrand Lapergue, Michel Piotin
INTRODUCTION: Mechanical thrombectomy for anterior circulation large vessel occlusion (LVO) improves functional outcome at three months. This therapeutic approach is the new gold standard, with a benefit being also observed in elderly patients. However, data are limited in this heterogeneous and fragile population. The objectives of this study were, first, to describe outcome after mechanical thrombectomy in a representative group of patients over 80. Second, to evaluate factors associated with a favorable functional outcome after thrombectomy for anterior circulation LVO in elderly patients (aged≥ 80 years)...
February 19, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29470721/association-of-ischemic-stroke-with-ankylosing-spondylitis-a-nationwide-longitudinal-cohort-study
#4
Dong Hyun Lee, Yoon Jin Choi, In-Bo Han, Je Beom Hong, Kyung Do Han, Jung Min Choi, Seil Sohn
BACKGROUND: The purpose of this nationwide age- and sex-matched longitudinal follow-up study was to investigate the risk of developing ischemic stroke in ankylosing spondylitis (AS). METHODS: The data in this study, spanning from January 1, 2010 to December 31, 2014, was obtained from a database maintained by the Korean National Health Insurance Service. A total of 12,988 patients with a diagnosis of AS were enrolled. The control group consisted of 64,940 age-sex-stratified matching subjects without AS...
February 22, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29470535/body-configuration-at-first-stepping-foot-contact-predicts-backward-balance-recovery-capacity-in-people-with-chronic-stroke
#5
Digna de Kam, Jolanda M B Roelofs, Alexander C H Geurts, Vivian Weerdesteyn
OBJECTIVE: To determine the predictive value of leg and trunk inclination angles at stepping-foot contact for the capacity to recover from a backward balance perturbation with a single step in people after stroke. METHODS: Twenty-four chronic stroke survivors and 21 healthy controls were included in a cross-sectional study. We studied reactive stepping responses by subjecting participants to multidirectional stance perturbations at different intensities on a translating platform...
2018: PloS One
https://www.readbyqxmd.com/read/29470495/reproducibility-of-preclinical-animal-research-improves-with-heterogeneity-of-study-samples
#6
Bernhard Voelkl, Lucile Vogt, Emily S Sena, Hanno Würbel
Single-laboratory studies conducted under highly standardized conditions are the gold standard in preclinical animal research. Using simulations based on 440 preclinical studies across 13 different interventions in animal models of stroke, myocardial infarction, and breast cancer, we compared the accuracy of effect size estimates between single-laboratory and multi-laboratory study designs. Single-laboratory studies generally failed to predict effect size accurately, and larger sample sizes rendered effect size estimates even less accurate...
February 2018: PLoS Biology
https://www.readbyqxmd.com/read/29470459/prevalence-of-self-reported-hypertension-and-antihypertensive-medication-use-among-adults-aged-%C3%A2-18-years-united-states-2011-2015
#7
Jing Fang, Cathleen Gillespie, Carma Ayala, Fleetwood Loustalot
Hypertension, which affects nearly one third of adults in the United States, is a major risk factor for heart disease and stroke (1), and only approximately half of those with hypertension have their hypertension under control (2). The prevalence of hypertension is highest among non-Hispanic blacks, whereas the prevalence of antihypertensive medication use is lowest among Hispanics (1). Geographic variations have also been identified: a recent report indicated that the Southern region of the United States had the highest prevalence of hypertension as well as the highest prevalence of medication use (3)...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29470452/who-environmental-noise-guidelines-for-the-european-region-a-systematic-review-on-environmental-noise-and-cardiovascular-and-metabolic-effects-a-summary
#8
REVIEW
Elise van Kempen, Maribel Casas, Göran Pershagen, Maria Foraster
To update the current state of evidence and assess its quality, we conducted a systematic review on the effects of environmental noise exposure on the cardio-metabolic systems as input for the new WHO environmental noise guidelines for the European Region. We identified 600 references relating to studies on effects of noise from road, rail and air traffic, and wind turbines on the cardio-metabolic system, published between January 2000 and August 2015. Only 61 studies, investigating different end points, included information enabling estimation of exposure response relationships...
February 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29470411/stroke-like-episodes-and-cerebellar-syndrome-in-phosphomannomutase-deficiency-pmm2-cdg-evidence-for-hypoglycosylation-driven-channelopathy
#9
Mercè Izquierdo-Serra, Antonio F Martínez-Monseny, Laura López, Julia Carrillo-García, Albert Edo, Juan Darío Ortigoza-Escobar, Óscar García, Ramón Cancho-Candela, M Llanos Carrasco-Marina, Luis G Gutiérrez-Solana, Daniel Cuadras, Jordi Muchart, Raquel Montero, Rafael Artuch, Celia Pérez-Cerdá, Belén Pérez, Belén Pérez-Dueñas, Alfons Macaya, José M Fernández-Fernández, Mercedes Serrano
Stroke-like episodes (SLE) occur in phosphomannomutase deficiency (PMM2-CDG), and may complicate the course of channelopathies related to Familial Hemiplegic Migraine (FHM) caused by mutations in CACNA1A (encoding CaV 2.1 channel). The underlying pathomechanisms are unknown. We analyze clinical variables to detect risk factors for SLE in a series of 43 PMM2-CDG patients. We explore the hypothesis of abnormal CaV 2.1 function due to aberrant N -glycosylation as a potential novel pathomechanism of SLE and ataxia in PMM2-CDG by using whole-cell patch-clamp, N -glycosylation blockade and mutagenesis...
February 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29470366/impact-of-angiotensin-converting-enzyme-inhibition-on-platelet-tissue-factor-expression-in-stroke-prone-rats
#10
Marta Brambilla, Paolo Gelosa, Laura Rossetti, Laura Castiglioni, Chiara Zara, Paola Canzano, Elena Tremoli, Luigi Sironi, Marina Camera
OBJECTIVE: Hypertension is a well known risk factor for thrombotic events such as myocardial infarction and stroke. Platelets express tissue factor (TF), the key activator of blood coagulation and thrombus formation. The number of TF-positive platelets increases in pathological conditions characterized by thrombotic complications but whether this occurs in hypertension is unknown. Here we investigated whether platelet TF expression is increased in a hypertensive status through a mechanism acting on megakaryocytes; the phenomenon could be modulated by antihypertensive drug as captopril; angiotensin (AngII) influences platelet TF expression...
February 21, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29470256/systematic-screening-in-hereditary-hemorrhagic-telangiectasia-a-review
#11
Steven Kroon, Repke J Snijder, Marie E Faughnan, Hans-Jurgen Mager
PURPOSE OF REVIEW: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inherited disease characterized by telangiectasia and arteriovenous malformations (AVMs). To date, five genetic types of HHT and one combined juvenile polyposis syndrome and HHT are known. Clinical and genetic screening of patients suspected with HHT is recommended to confirm the diagnosis and to prevent complications associated with HHT. The aim of this article is to give an overview of the evidence and to formulate a recommendation for clinicians concerning screening for HHT...
February 20, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29470156/journal-club-evaluation-of-diffusion-kurtosis-imaging-of-stroke-lesion-with-hemodynamic-and-metabolic-mri-in-a-rodent-model-of-acute-stroke
#12
Dongshuang Lu, Yinghua Jiang, Yang Ji, Iris Yuwen Zhou, Emiri Mandeville, Eng H Lo, Xiaoying Wang, Phillip Zhe Sun
OBJECTIVE: Diffusion kurtosis imaging (DKI) has emerged as a new acute stroke imaging approach, augmenting routine DWI. Although it has been shown that a diffusion lesion without kurtosis abnormality is more likely to recover after reperfusion, whereas a kurtosis lesion shows poor response, little is known about the underlying pathophysiologic profile of the kurtosis lesion versus the kurtosis lesion-diffusion lesion mismatch. MATERIALS AND METHODS: We performed multiparametric MRI, including arterial spin labeling, pH-sensitive amide proton transfer, and DKI, in a rodent model of acute stroke caused by embolic middle cerebral artery occlusion...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29470134/the-effect-of-aronia-berry-on-type-1-diabetes-in-vivo-and-in-vitro
#13
Yong-Deok Jeon, Sa-Haeng Kang, Kwang-Hyun Moon, Jeong-Ho Lee, Dae-Geun Kim, Wook Kim, Jong-Sung Kim, Byung-Yong Ahn, Jong-Sik Jin
The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe...
February 22, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29469705/herpes-zoster-ophthalmicus-with-associated-vasculopathy-causing-stroke
#14
Camila Antia, Leah Persad, Ali Alikhan
Varicella zoster virus (VZV) is an exclusively human, double-stranded DNA virus. Primary infection causes varicella (chickenpox); later the virus becomes dormant in the dorsal root, cranial nerve, and autonomic ganglia along the entire span of the nervous system, retaining the capacity to reactivate and cause a variety of dermal and neurological complications. Recently there has been increasing recognition, both clinically and epidemiologically, of the relationship between VZV and subsequent strokes. Herein, we describe a case of a previously healthy individual with reactivation of VZV causing herpes zoster opthtalmicus along with devastating multifocal vasculopathy...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469668/review-of-de-novo-cerebral-arteriovenous-malformation-haemorrhage-risk-treatment-approaches-and-outcomes
#15
Xianli Lv, Guihuai Wang
Objective A small number of patients has been reported to develop a completely new or de novo arteriovenous malformation (AVM) after brain surgery, haemorrhage, head trauma or ischaemic stroke. The natural history of these lesions is unknown. In this review, both ruptured and unruptured de novo AVMs and their treatments were reviewed. Methods Published literature in the PubMed database citing 'de novo cerebral arteriovenous malformation' was reviewed. Additional studies were identified through reference searches in each reviewed article...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29469619/visual-search-in-unilateral-spatial-neglect-the-effects-of-distractors-on-a-dynamic-visual-search-task
#16
Rebeca Lauren Emerson, Alberto García-Molina, Jaume López Carballo, Juan García Fernández, Celeste Aparicio-López, Junquera Novo, Rocío Sánchez-Carrión, Antonia Enseñat-Cantallops, Jordi Peña-Casanova
The objective of this study was to examine visual scanning performance in patients with Unilateral Spatial Neglect (USN) in a visual search task. Thirty-one right hemisphere stroke patients with USN were recruited. They performed a dynamic visual search task with two conditions, with and without distractors, while eye movements were monitored with an eye-tracker. The main goal of the task was to select target stimuli that appeared from the top of the screen and moved vertically downward. Target detection and visual scanning percentage were assessed over two hemispaces (right, left) on two conditions (distractor, no distractor)...
February 22, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29469020/changes-in-nutritional-state-and-dysphagia-in-stroke-patients-monitored-during-a-14-d-period-in-a-burkina-faso-hospital-setting
#17
Jeoffray Diendéré, Athanase Millogo, Pierre-Marie Preux, Pierre Jésus, Jean-Claude Desport
INTRODUCTION: Dysphagia and undernourishment are common in cerebrovascular accident (stroke) patients in developed countries. Despite the dietary transition, there is little information available in Africa on this topic. This study aims to assess the prevalence of undernourishment and dysphagia in stroke patients in two Burkina Faso teaching hospitals at a starting point (D0), on the eighth day, and on the 14th (D14) and to specify factors related to undernourishment at day 14. METHODOLOGY: The nutritional state of the patients was assessed using body mass index, triceps skinfold thickness, and mid-upper arm circumference...
November 27, 2017: Nutrition
https://www.readbyqxmd.com/read/29468984/vad-an-integrated-framework-for-cognitive-rehabilitation
#18
Dafin F Muresanu, Dana Slavoaca, Antox Alvarez, Volker Homberg, Ovidiu Bajenaru, Alla Guekht, Wolf-Dieter Heiss, Livia Popa, Johannes Vester, Ioana Muresanu, Codruta Birle, Maria Balea
Vascular dementia is the second most common cause of dementia, with clinical features that depend on neural substrates affected by the vascular lesions. Like most neurological disorders, it involves alterations that range from the molecular level to neuronal networks. Such alterations begin as compensatory mechanisms that reshape every subsystem involved in the brain's homeostasis. Although there have been recent huge advances in understanding the pathophysiology of cognitive dysfunction, a suitable therapeutic approach to vascular dementia remains elusive...
February 19, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29468958/impact-of-pre-procedural-cerebrovascular-events-on-clinical-outcomes-after-transcatheter-aortic-valve-implantation-in-patients-with-severe-aortic-stenosis
#19
Agata Wiktorowicz, Pawel Kleczynski, Artur Dziewierz, Tomasz Tokarek, Danuta Sorysz, Maciej Bagienski, Lukasz Rzeszutko, Dariusz Dudek
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is an increasingly common treatment of symptomatic severe aortic valve stenosis (AS). Thus, it is reasonable to carefully investigate the impact of individual clinical factors on outcomes after TAVI. OBJECTIVES: We aimed to investigate the impact of the previous cerebro-vascular events (CVEs) on outcomes of patients with severe AS undergoing TAVI. METHODS: A total of 148 consecutive patients scheduled for TAVI were included and stratified as with and without a history of CVEs (stroke or transient ischemic attack)...
February 19, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29468787/association-of-dialysis-with-in-hospital-disability-progression-and-mortality-in-community-onset-stroke
#20
Tomoko Usui, Norio Hanafusa, Hideo Yasunaga, Masaomi Nangaku
AIM: End-stage renal disease is associated with increased risk of cerebrovascular disease, but the effect on post-stroke clinical outcomes has not been thoroughly investigated. METHODS: Using the Japanese Diagnosis Procedure Combination database, which includes administrative claims and discharge abstract data, we examined the association between risk factors including dialysis therapy and in-hospital disability progression or mortality in patients with community-onset stroke...
February 22, 2018: Nephrology
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