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Bénazir Siddeek, Nadjem Lakhdari, Lilia Inoubli, Rachel Paul-Bellon, Véronique Isnard, Emmanuelle Thibault, André Bongain, Daniel Chevalier, Emanuela Repetto, Michele Trabucchi, Jean-François Michiels, Catherine Yzydorczyk, Umberto Simeoni, Michel Urtizberea, Claire Mauduit, Mohamed Benahmed
AIM: The Developmental Origin of Health and Disease refers to the concept that early exposure to toxicants or nutritional imbalances during perinatal life induces changes that enhance the risk of developing noncommunicable diseases in adulthood. Patients/materials & methods: An experimental model with an adult chronic germ cell phenotype resulting from exposure to a xenoestrogen was used. RESULTS: A reciprocal negative feedback loop involving decreased EZH2 protein level and increased miR-101 expression was identified...
October 20, 2016: Epigenomics
Ishfaq A Sheikh, Iftikhar A Tayubi, Ejaz Ahmad, Majid A Ganaie, Osama S Bajouh, Samera F AlBasri, Ibtihal M J Abdulkarim, Mohd A Beg
Environmental contamination has been one of the major drawbacks of the industrial revolution. Several man-made chemicals are constantly released into the environment during the manufacturing process and by leaching from the industrial products. As a result, human and animal populations are exposed to these synthetic chemicals on a regular basis. Many of these chemicals have adverse effects on the physiological functions, particularly on the hormone systems in human and animals and are called endocrine disrupting chemicals (EDCs)...
October 14, 2016: Ecotoxicology and Environmental Safety
Katharina Vejdovszky, Verena Schmidt, Benedikt Warth, Doris Marko
SCOPE: The isoflavone genistein, present in soy-based food and dietary supplements, is known for its estrogenic potential. In addition to phytoestrogens, food may also contain mycotoxins with estrogenic properties like zearalenone or alternariol, raising the question on potential combinatory effects of these xenoestrogens. METHODS AND RESULTS: Combinatory estrogenic effects of genistein with zeralenone or alternariol were studied in the human endometrial adenocarcinoma cell line Ishikawa as expression of alkaline phosphatase (AlP) activity...
October 14, 2016: Molecular Nutrition & Food Research
Courtney E Hart, Michael J Lauth, Cassidy S Hunter, Brennan R Krasny, Kristin M Hardy
The xenoestrogen 4-nonylphenol (NP) is a ubiquitous aquatic pollutant and has been shown to impair reproduction, development, growth and, more recently, immune function in marine invertebrates. We investigated the effects of short-term (7 d) exposure to low (2 μg l(-1)) and high (100 μg l(-1)) levels of NP on cellular and humoral elements of the innate immune response of Crassostrea gigas to a bacterial challenge. To this end, we measured 1) total hemocyte counts (THC), 2) relative transcript abundance of ten immune-related genes (defh1, defh2, bigdef1, bigdef2, bpi, lysozyme-1, galectin, C-type lectin 2, timp, and transglutaminase) in the hemocytes, gill and mantle, and 3) hemolymph plasma lysozyme activity, following experimental Vibrio campbellii infection...
September 28, 2016: Fish & Shellfish Immunology
Zaosheng Wang, Rui Li, Fengchang Wu, Chenglian Feng, Chun Ye, Changzhou Yan
The occurrence and distribution of target estrogenic compounds in a highly urbanized industry-impacted coastal bay were investigated, and contamination profiles were evaluated by estimating total estradiol equivalents (∑EEQs) and risk quotients (RQs). Phenolic compounds were the most abundant xenoestrogens, but seldom showed contribution to the ∑EEQs. The diethylstilbestrol (DES) and 17α-ethinylestradiol (EE2) were the major contributors followed by 17β-estradiol (E2) in comparison with a slight contribution from estrone (E1) and estriol (E3)...
September 24, 2016: Marine Pollution Bulletin
Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, Vinothini Govindarajah, Yuet-Kin Leung, Shuk-Mei Ho
Exposure to xenoestrogens is a probable cause of male infertility in humans. Consumption of high-fat diets and exposure to bisphenol A (BPA) is pervasive in America. Here, we test the hypothesis that gestational exposure to high dietary fats and/or BPA disrupt spermatogenesis in adulthood. Sprague-Dawley rats were fed diets containing 10 kcal% butter fat (AIN), 39 kcal% butter fat (HFB), or 39 kcal% olive oil (HFO), with or without BPA (25μg/kg body weight/day) during pregnancy. One group of male offspring received testosterone (T)- and estradiol-17β (E2)-filled implants or sham-implants from postnatal day (PND)70-210...
September 19, 2016: Reproductive Toxicology
Tafzila Akter Mouly, Leisa-Maree Leontjew Toms
Persistent organic pollutants (POPs) are a group of heterogeneous compounds of both natural and anthropogenic origin with highly persistent and bioaccumulative properties. They cause a range of adverse effects to human health and the environment around the world. There is growing concern that POPs may increase breast cancer risk due to their xenoestrogenic properties. The aim of this systematic literature review is to summarize and integrate the risks of breast cancer following environmental exposure to POPs (other than DDT) from primary epidemiological studies published between 2006 and 2015...
September 15, 2016: Environmental Science and Pollution Research International
D Sarrouilhe, C Dejean
The etiology of autism spectrum disorders (ASD) is believed to be multifactorial and to involve genetic and environmental components. Environmental chemical exposures are increasingly understood to be important in causing neurotoxicity in fetuses and newborns. Recent data from the Centers for Disease Control and Prevention in the United States suggest a substantial increase in ASD prevalence, only partly explicable by factors such as diagnostic substitution. Bisphenol A (BPA) is an ubiquitous xenoestrogen widely employed in a variety of consumer products including plastic and metal food and beverage containers, dental sealants and fillings, medical equipment and thermal receipts...
September 9, 2016: L'Encéphale
Sohrab Kazemi, Seydeh Narges Mousavi Kani, Maryam Ghasemi-Kasman, Fahimeh Aghapour, Hamidreza Khorasani, Ali Akbar Moghadamnia
BACKGROUND: Nonylphenol (NP) is one of the most widely used synthetic xenoestrogens in detergents, plastic products, paints and the most important environmental degradation factor. In this study, the effects NP was investigated on hepatic oxidative stress-related gene expression in rats. METHOD: Wistar male rats weighing 150-200 g were divided into control and NP receiving groups. NP was given in three doses (5, 25, and 125 μg/kg). All doses were given by gavage and the experiment continued for a consecutive 35 days...
October 7, 2016: Biochemical and Biophysical Research Communications
M Angeles Lillo, Cydney Nichols, Chanel Perry, Stephanie Runke, Raisa Krutilina, Tiffany N Seagroves, Gustavo A Miranda-Carboni, Susan A Krum
A body of epidemiological evidence implicates exposure to endocrine disrupting chemicals (EDCs) with increased susceptibility to breast cancer. To evaluate the physiological effects of a suspected EDC in vivo, we exposed MCF-7 breast cancer cells and a patient-derived xenograft (PDX, estrogen receptor positive) to physiological levels of methylparaben (mePB), which is commonly used in personal care products as a preservative. mePB pellets (4.4 μg per day) led to increased tumor size of MCF-7 xenografts and ER(+) PDX tumors...
September 1, 2016: Journal of Applied Toxicology: JAT
Zhi-Hua Liu, Jin-Jun Ding, Qian-Qian Yang, Hua-Zeng Song, Xiang-Tao Chen, Yi Xu, Gui-Ran Xiao, Hui-Li Wang
Bisphenol-A (BPA, 4, 4'-isopropylidene-2-diphenol), a synthetic xenoestrogen that widely used in the production of polycarbonate plastics, has been reported to impair hippocampal development and function. Our previous study has shown that BPA exposure impairs Sprague-Dawley (SD) male hippocampal dendritic spine outgrowth. In this study, the sex-effect of chronic BPA exposure on spatial memory in SD male and female rats and the related synaptic mechanism were further investigated. We found that chronic BPA exposure impaired spatial memory in both SD male and female rats, suggesting a dysfunction of hippocampus without gender-specific effect...
2016: Scientific Reports
Sarah Potratz, Patrick Tarnow, Harald Jungnickel, Sven Baumann, Martin von Bergen, Tewes Tralau, Andreas Luch
The disruptive potential of xenoestrogens like bisphenol A (BPA) lies in their 17β-estradiol (E2)-like binding to estrogen receptors (ERs) followed by concomitant modulation of ER target gene expression. Unsurprisingly most endocrine testing systems focus on the quantification of canonical transcripts or ER-sensitive reporters. However, only little information is available about the corresponding metabolomic changes in vitro. This knowledge gap becomes particularly relevant in the context of potential mixture effects, for example as a consequence of co-exposure to potentially estrogenically active pollutants (e...
August 12, 2016: Chemical Research in Toxicology
Md Saidur Rahman, Woo-Sung Kwon, Sung-Jae Yoon, Yoo-Jin Park, Buom-Yong Ryu, Myung-Geol Pang
BACKGROUND: Although the toxicological impacts of the xenoestrogen bisphenol-A (BPA) have been studied extensively, but the mechanism of action is poorly understood. Eventually, no standard method exists for evaluating the possible health hazards of BPA exposure. Considering mice spermatozoa as a potential in vitro model, we investigated the effects of BPA exposure (0.0001, 0.01, 1, and 100 μM for 6 h) on spermatozoa and the related mechanisms of action. The same doses were also employed to evaluate protein profiles of spermatozoa as a means to monitor their functional affiliation to diseases...
2016: BMC Genomics
Katerina Makarova, Pawel Siudem, Katarzyna Zawada, Justyna Kurkowiak
Bisphenol A (BPA) acts as an endocrine-disrupting compound even at a low concentration. Degradation of BPA could lead to the formation of toxic products. In this study, we compare the toxicity of BPA and seven intermediate products of its degradation. The accuracy of three molecular docking programs (Surflex, Autodock, and Autodock Vina) in predicting the binding affinities of selected compounds to human (ERα, ERβ, and ERRγ) and zebrafish (ERα, ERRγA, and ERRγB) estrogen and estrogen-related receptors was evaluated...
October 2016: Zebrafish
Christian Bjerregaard-Olesen, Mandana Ghisari, Eva C Bonefeld-Jørgensen
Humans are exposed to a wide variety of perfluorinated alkyl acids (PFAAs). Several studies have found xenoestrogenic activity of single PFAAs. Studies on mixture effects of the PFAAs are however sparse. In the present study, we aimed to determine the xenoestrogenic activity in human serum extracts containing mixtures of PFAAs. Recently we developed a method to extract the PFAAs from human serum with simultaneous removal of endogenous hormones and interfering steroid metabolites. We used this method to extract the PFAAs from serum of 397 Danish nulliparous pregnant women followed by analysis of estrogen receptor (ER) transactivation using MVLN cells carrying an estrogen response element luciferase reporter vector...
July 21, 2016: Environmental Research
Yu Liu, Ya-Long Wang, Ming-Huang Chen, Zhen Zhang, Bai-Hui Xu, Rui Liu, Lin Xu, Shu-Wen He, Fei-Ping Li, Zhong-Quan Qi, Hai-Long Wang
Methoxychlor (MXC) is used worldwide against insects and other pests. This organochlorine pesticide acts as a xenoestrogen, promotes oxidative stress, and is considered cytotoxic and genotoxic, causing abortions and stillbirths in females. Mechanistically related estrogens and oxidants affect oocyte meiosis, so we investigated the effects of MXC on mouse oocyte meiotic maturation. Our results showed that maturation rates of MXC-treated oocytes were lower than those of controls, which was due to abnormal spindle morphologies and DNA double-strand breaks, as confirmed by increased γ-H2AX foci...
September 2016: Molecular Reproduction and Development
Jian Gong, Dandan Duan, Yu Yang, Yong Ran, Diyun Chen
Endocrine disrupting chemicals (EDCs) were seasonally investigated in surface water, suspended particulate matter, and sediments of the Pearl River Delta (PRD), South China. EDC concentrations in the surface water were generally higher in the summer than in winter. The surface water in the investigated rivers was heavily contaminated by the phenolic xenoestrogens. Moreover, the in-situ log Ksoc and log Kpoc values and their regression with log Kow in the field experiments suggest that binding mechanisms other than hydrophobic interaction are present for the sedimentary organic carbon and particulate organic carbon (SOC/POC)...
July 15, 2016: Environmental Pollution
Judith Trapp, Jean Armengaud, Jean-Charles Gaillard, Olivier Pible, Arnaud Chaumot, Olivier Geffard
UNLABELLED: In environmental science, omics-based approaches are widely used for the identification of gene products related to stress response. However, when dealing with non-model species, functional prediction of genes is challenging. Indeed, functional predictions are often obtained by sequence similarity searches and functional data from phylogenetically distant organisms, which can lead to inaccurate predictions due to quite different evolutionary scenarios. In oviparous females, vitellogenin production is vital for embryonic development, ensuring population viability...
September 2, 2016: Journal of Proteomics
Cristina Bizarro, Marta Eide, Daniel J Hitchcock, Anders Goksøyr, Maren Ortiz-Zarragoitia
The low concentrations of most contaminants in the aquatic environment individually may not affect the normal function of the organisms on their own. However, when combined, complex mixtures may provoke unexpected effects even at low amounts. Selected aquatic micropollutants such as chlorpyrifos, bis-(2-ethylhexyl)-phthalate (DEHP), perfluorooctanoic acid (PFOA) and 17α-ethinylestradiol (EE2) were tested singly and in mixtures at nM to μM concentrations using precision-cut liver slices (PCLS) of Atlantic cod (Gadus morhua)...
August 2016: Aquatic Toxicology
Seyed Mohsen Aghajanpour-Mir, Ebrahim Zabihi, Haleh Akhavan-Niaki, Elahe Keyhani, Iman Bagherizadeh, Sajjad Biglari, Farkhondeh Behjati
Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification. In this study, we investigated the BPA-induced chromosomal damages in MCF-7 cell line, ER-positive and negative amniocyte cells...
2016: International Journal of Molecular and Cellular Medicine
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