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cancer and Xenoestrogens

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https://www.readbyqxmd.com/read/28855101/in-vitro-observations-and-in-silico-predictions-of-xenoestrogen-mixture-effects-in-t47d-based-receptor-transactivation-and-proliferation-assays
#1
Nina Schlotz, Gwang-Jin Kim, Stefan Jäger, Stefan Günther, Evelyn Lamy
Within endocrine disruptor research, evaluation and interpretation of mixture effects and the predictive value for downstream responses still warrant more in-depth investigations. We used an estrogen receptor (ER)-mediated reporter gene assay (ER-CALUX®) and a cell proliferation assay (WST-1 assay), both based on the T47D breast cancer cell line, to test mixtures of heterogeneous xenoestrogens. Observed concentration-response curves were compared to those predicted by the concepts of concentration addition (CA), generalized concentration addition (GCA), and a novel full logistic model (FLM)...
August 30, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28763032/a-chip-for-estrogen-receptor-action-detection-of-biomarkers-released-by-mcf-7-cells-through-estrogenic-and-anti-estrogenic-effects
#2
Konstanze Gier, Claudia Preininger, Ursula Sauer
The fluorescence-based multi-analyte chip platform for the analysis of estrogenic and anti-estrogenic substances is a new in vitro tool for the high throughput screening of environmental samples. In contrast to existing tools, the chip investigates the complex action of xenoestrogens in a human cell model by characterizing protein expression. It allows for the quantification of 10 proteins secreted by MCF-7 cells, representing various biological and pathological endpoints of endocrine action and distinguishing between estrogen- and anti-estrogen-dependent secretion of proteins...
August 1, 2017: Sensors
https://www.readbyqxmd.com/read/28717100/inhibitory-modulation-of-human-estrogen-receptor-%C3%AE-and-%C3%AE-activities-by-dicyclohexyl-phthalate-in-human-breast-cancer-cell-lines
#3
Hiroyuki Okazaki, Shuso Takeda, Saki Matsuo, Masaya Matsumoto, Erika Furuta, Eriko Kohro-Ikeda, Hironori Aramaki
Phthalate esters (PAEs) are man-made compounds that are used widely in industry, and the ubiquitous exposure of humans to PAEs has been reported. Although some PAEs have been suggested to function as xenoestrogens in in vitro systems, such as human estrogen receptors (ERs) expressed in Chinese hamster ovary (CHO)-K1 cells, few studies have attempted to elucidate whether PAEs affect human ERα/ERβ-mediated signaling in human breast cancer cells (i.e., combination between human ERs and human cells). Thus, further experiments are needed in order to clarify the activities of PAEs...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28703301/the-xenoestrogens-biphenol-a-and-nonylphenol-differentially-regulate-metalloprotease-mediated-shedding-of-egfr-ligands
#4
Paulina Urriola-Muñoz, Xue Li, Thorsten Maretzky, David R McIlwain, Tak W Mak, Juan G Reyes, Carl P Blobel, Ricardo D Moreno
The xenoestrogens bisphenol-A (BPA) and nonylphenol (NP) are endocrine disruptors used in the plastic polymer industry to manufacture different products for human use. Previous studies have suggested a role of these compounds in the shedding of signaling molecules, such as tumor necrosis factor α (TNF-α). The aim of this work was to evaluate the effect of BPA and NP on the sheddase ADAM17 and its newly discovered regulators iRhom1 and iRhom2 in the release of EGFR-ligands. We report that BPA and NP can stimulate the release of the ADAM17-substrates HB-EGF and TGF-α...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28549265/facile-screening-of-potential-xenoestrogens-by-an-estrogen-receptor-based-reusable-optical-biosensor
#5
Lanhua Liu, Xiaohong Zhou, Yun Lu, Didi Shan, Bi Xu, Miao He, Hanchang Shi, Yi Qian
The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of screening xenoestrogens. We reported an estrogen receptor (ER)-based reusable fiber biosensor for facile screening estrogenic compounds in environment. The bioassay is based on the competition of xenoestrogens with 17β-estradiol (E2) for binding to the recombinant receptor of human estrogen receptor α (hERα) protein, leaving E2 free to bind to fluorophore-labeled anti-E2 monoclonal antibody...
May 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28521190/simultaneous-determination-of-bisphenol-a-and-estrogens-in-hair-samples-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#6
Chaelin Lee, Chong Hyeak Kim, Sunghwan Kim, Sung-Hee Cho
Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28288811/changes-in-the-total-effective-xenoestrogen-burden-texb-of-breast-cancer-patients-during-an-18-month-post-surgical-follow-up
#7
Mariana F Fernandez, Jose Pumarega, Miquel Porta, Jose Manuel Molina-Molina, Juan P Arrebola, Nicolas Olea
We aimed to assess changes in the total effective xenoestrogen burden (TEXB) -a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women...
March 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28263720/simvastatin-down-regulates-differential-genetic-profiles-produced-by-organochlorine-mixtures-in-primary-breast-cell-hmec
#8
LETTER
Javier Rivero, Luis Alberto Henríquez-Hernández, Luis D Boada, Jose Pestano, Octavio P Luzardo, María Camacho, Manuel Zumbado, Pilar F Valerón
Women all over the world are exposed to an unavoidable contamination by organochlorine pesticides and other chemical pollutants. Many of them are considered as xenoestrogens and have been associated with the development and progression of breast cancer. We have demonstrated that the most prevalent pesticide mixtures found in healthy women and in women diagnosed with breast cancer modulates the gene expression in human epithelial mammary cells. Statins are well-known cholesterol-depleting agents acting as inhibitors of cholesterol synthesis...
April 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28078498/perinatal-exposure-to-bisphenol-a-or-diethylstilbestrol-increases-the-susceptibility-to-develop-mammary-gland-lesions-after-estrogen-replacement-therapy-in-middle-aged-rats
#9
Ayelen L Gomez, Melisa B Delconte, Gabriela A Altamirano, Lucia Vigezzi, Veronica L Bosquiazzo, Luís F Barbisan, Jorge G Ramos, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
The development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland...
January 11, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/27902959/kaempferol-a-phytoestrogen-suppressed-triclosan-induced-epithelial-mesenchymal-transition-and-metastatic-related-behaviors-of-mcf-7-breast-cancer-cells
#10
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
As a phytoestrogen, kaempferol is known to play a chemopreventive role inhibiting carcinogenesis and cancer progression. In this study, the influences of triclosan, an anti-bacterial agent recently known for an endocrine disrupting chemical (EDC), and kaempferol on breast cancer progression were examined by measuring their effects on epithelial-mesenchymal transition (EMT) and metastatic-related behaviors of MCF-7 breast cancer cells. Morphological changes of MCF-7 cells were observed, and a wound-healing assay was performed after the treatment of triclosan and kaempferol...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27863841/the-role-and-impact-of-estrogens-and-xenoestrogen-on-the-development-of-cervical-cancer
#11
REVIEW
Dorota Ewa Bronowicka-Kłys, Margarita Lianeri, Paweł Piotr Jagodziński
Throughout an individual's lifetime, the human body is exposed to many different chemical compounds, including xenoestrogens (XEs) that can be found in the environment, food, air, cosmetics and other substances, which have a positive or negative impact on their health and lifestyle. Whereas high-risk human papillomavirus (HR-HPV) is necessary but not sufficient for full malignant cervical cell transformation, other compounds such as estrogens and XEs may be risk factors for cervical cancer (CC) development...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27816767/xenoestrogen-regulation-of-er%C3%AE-er%C3%AE-balance-in-hormone-associated-cancers
#12
Filippo Acconcia, Marco Fiocchetti, Maria Marino
The hormone 17β-estradiol (E2) contributes to body homeostasis maintenance by regulating many different physiological functions in both male and female organs. E2 actions in reproductive and non-reproductive tissues rely on a complex net of nuclear and extra-nuclear signal transduction pathways triggered by at least two estrogen receptor subtypes (ERα and ERβ). Consequently, the de-regulation of E2:ER signaling contributes to the pathogenesis of many diseases including cancer. Among other factors, the ERα/ERβ ratio is considered one of the pivotal mechanisms at the root of E2 action in cancer progression...
November 2, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27628920/breast-cancer-and-persistent-organic-pollutants-excluding-ddt-a-systematic-literature-review
#13
REVIEW
Tafzila Akter Mouly, Leisa-Maree Leontjew Toms
Persistent organic pollutants (POPs) are a group of heterogeneous compounds of both natural and anthropogenic origin with highly persistent and bioaccumulative properties. They cause a range of adverse effects to human health and the environment around the world. There is growing concern that POPs may increase breast cancer risk due to their xenoestrogenic properties. The aim of this systematic literature review is to summarize and integrate the risks of breast cancer following environmental exposure to POPs (other than DDT) from primary epidemiological studies published between 2006 and 2015...
November 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27581495/methylparaben-stimulates-tumor-initiating-cells-in-er-breast-cancer-models
#14
M Angeles Lillo, Cydney Nichols, Chanel Perry, Stephanie Runke, Raisa Krutilina, Tiffany N Seagroves, Gustavo A Miranda-Carboni, Susan A Krum
A body of epidemiological evidence implicates exposure to endocrine disrupting chemicals (EDCs) with increased susceptibility to breast cancer. To evaluate the physiological effects of a suspected EDC in vivo, we exposed MCF-7 breast cancer cells and a patient-derived xenograft (PDX, estrogen receptor positive) to physiological levels of methylparaben (mePB), which is commonly used in personal care products as a preservative. mePB pellets (4.4 μg per day) led to increased tumor size of MCF-7 xenografts and ER(+) PDX tumors...
April 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27507061/a-novel-approach-to-assessing-bisphenol-a-hazards-using-an-in-vitro-model-system
#15
Md Saidur Rahman, Woo-Sung Kwon, Sung-Jae Yoon, Yoo-Jin Park, Buom-Yong Ryu, Myung-Geol Pang
BACKGROUND: Although the toxicological impacts of the xenoestrogen bisphenol-A (BPA) have been studied extensively, but the mechanism of action is poorly understood. Eventually, no standard method exists for evaluating the possible health hazards of BPA exposure. Considering mice spermatozoa as a potential in vitro model, we investigated the effects of BPA exposure (0.0001, 0.01, 1, and 100 μM for 6 h) on spermatozoa and the related mechanisms of action. The same doses were also employed to evaluate protein profiles of spermatozoa as a means to monitor their functional affiliation to diseases...
August 9, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27386435/the-genotoxic-and-cytotoxic-effects-of-bisphenol-a-bpa-in-mcf-7-cell-line-and-amniocytes
#16
Seyed Mohsen Aghajanpour-Mir, Ebrahim Zabihi, Haleh Akhavan-Niaki, Elahe Keyhani, Iman Bagherizadeh, Sajjad Biglari, Farkhondeh Behjati
Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification. In this study, we investigated the BPA-induced chromosomal damages in MCF-7 cell line, ER-positive and negative amniocyte cells...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/27312807/preferential-epigenetic-programming-of-estrogen-response-after-in-utero-xenoestrogen-bisphenol-a-exposure
#17
Elisa M Jorgensen, Myles H Alderman, Hugh S Taylor
Bisphenol-A (BPA) is an environmentally ubiquitous estrogen-like endocrine-disrupting compound. Exposure to BPA in utero has been linked to female reproductive disorders, including endometrial hyperplasia and breast cancer. Estrogens are an etiological factor in many of these conditions. We sought to determine whether in utero exposure to BPA altered the global CpG methylation pattern of the uterine genome, subsequent gene expression, and estrogen response. Pregnant mice were exposed to an environmentally relevant dose of BPA or DMSO control...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27203080/total-effective-xenoestrogen-burden-in-serum-samples-and-risk-for-breast-cancer-in-a-population-based-multicase-control-study-in-spain
#18
Roberto Pastor-Barriuso, Mariana F Fernández, Gemma Castaño-Vinyals, Denis Whelan, Beatriz Pérez-Gómez, Javier Llorca, Cristina M Villanueva, Marcela Guevara, José-Manuel Molina-Molina, Francisco Artacho-Cordón, Laura Barriuso-Lapresa, Ignasi Tusquets, Trinidad Dierssen-Sotos, Nuria Aragonés, Nicolás Olea, Manolis Kogevinas, Marina Pollán
BACKGROUND: Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES: We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS: A total of 186 incident pretreatment breast cancer cases and 196 frequency-matched controls were randomly sampled from a large population-based multicase-control study in Spain...
October 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27038254/bisphenol-a-increases-the-migration-and-invasion-of-triple-negative-breast-cancer-cells-via-oestrogen-related-receptor-gamma
#19
Xiao-Lin Zhang, Na Liu, Shan-Fan Weng, Hong-Sheng Wang
Triple-negative breast cancer (TNBC) is characterized by great metastasis and invasion capability. Our study revealed that nanomolar bisphenol A (BPA), one of the most ubiquitous endocrine disruptors, can increase wound closure and invasion of both MDA-MB-231 and BT-549 cells. BPA treatment can increase protein and mRNA expression of matrix metalloproteinase-2 (MMP-2) and MMP-9, while had no effect on the expression of vimentin (Vim) and fibronectin (FN) in TNBC cells. The expression of G-protein-coupled receptor (GPER), which has been suggested to mediate rapid oestrogenic signals, was not varied in BPA-treated MDA-MB-231 and BT-549 cells...
October 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27026707/the-g-protein-coupled-estrogen-receptor-agonist-g-1-inhibits-nuclear-estrogen-receptor-activity-and-stimulates-novel-phosphoproteomic-signatures
#20
L Cody Smith, Kimberly J Ralston-Hooper, P Lee Ferguson, Tara Sabo-Attwood
Estrogen exerts cellular effects through both nuclear (ESR1 and ESR2) and membrane-bound estrogen receptors (G-protein coupled estrogen receptor, GPER); however, it is unclear if they act independently or engage in crosstalk to influence hormonal responses. To investigate each receptor's role in proliferation, transcriptional activation, and protein phosphorylation in breast cancer cells (MCF-7), we employed selective agonists for ESR1 propyl-pyrazole-triol (PPT), ESR2 diarylpropionitrile (DPN), and GPER (G-1) and also determined the impact of xenoestrogens bisphenol-A (BPA) and genistein on these effects...
June 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
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