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cancer and Xenoestrogens

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https://www.readbyqxmd.com/read/27902959/kaempferol-a-phytoestrogen-suppressed-triclosan-induced-epithelial-mesenchymal-transition-and-metastatic-related-behaviors-of-mcf-7-breast-cancer-cells
#1
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
As a phytoestrogen, kaempferol is known to play a chemopreventive role inhibiting carcinogenesis and cancer progression. In this study, the influences of triclosan, an anti-bacterial agent recently known for an endocrine disrupting chemical (EDC), and kaempferol on breast cancer progression were examined by measuring their effects on epithelial-mesenchymal transition (EMT) and metastatic-related behaviors of MCF-7 breast cancer cells. Morphological changes of MCF-7 cells were observed, and a wound-healing assay was performed after the treatment of triclosan and kaempferol...
November 22, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27863841/the-role-and-impact-of-estrogens-and-xenoestrogen-on-the-development-of-cervical-cancer
#2
REVIEW
Dorota Ewa Bronowicka-Kłys, Margarita Lianeri, Paweł Piotr Jagodziński
Throughout an individual's lifetime, the human body is exposed to many different chemical compounds, including xenoestrogens (XEs) that can be found in the environment, food, air, cosmetics and other substances, which have a positive or negative impact on their health and lifestyle. Whereas high-risk human papillomavirus (HR-HPV) is necessary but not sufficient for full malignant cervical cell transformation, other compounds such as estrogens and XEs may be risk factors for cervical cancer (CC) development...
November 15, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27816767/xenoestrogen-regulation-of-er%C3%AE-er%C3%AE-balance-in-hormone-associated-cancers
#3
Filippo Acconcia, Marco Fiocchetti, Maria Marino
The hormone 17β-estradiol (E2) contributes to body homeostasis maintenance by regulating many different physiological functions in both male and female organs. E2 actions in reproductive and non-reproductive tissues rely on a complex net of nuclear and extra-nuclear signal transduction pathways triggered by at least two estrogen receptor subtypes (ERα and ERβ). Consequently, the de-regulation of E2:ER signaling contributes to the pathogenesis of many diseases including cancer. Among other factors, the ERα/ERβ ratio is considered one of the pivotal mechanisms at the root of E2 action in cancer progression...
November 2, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27628920/breast-cancer-and-persistent-organic-pollutants-excluding-ddt-a-systematic-literature-review
#4
Tafzila Akter Mouly, Leisa-Maree Leontjew Toms
Persistent organic pollutants (POPs) are a group of heterogeneous compounds of both natural and anthropogenic origin with highly persistent and bioaccumulative properties. They cause a range of adverse effects to human health and the environment around the world. There is growing concern that POPs may increase breast cancer risk due to their xenoestrogenic properties. The aim of this systematic literature review is to summarize and integrate the risks of breast cancer following environmental exposure to POPs (other than DDT) from primary epidemiological studies published between 2006 and 2015...
September 15, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27581495/methylparaben-stimulates-tumor-initiating-cells-in-er-breast-cancer-models
#5
M Angeles Lillo, Cydney Nichols, Chanel Perry, Stephanie Runke, Raisa Krutilina, Tiffany N Seagroves, Gustavo A Miranda-Carboni, Susan A Krum
A body of epidemiological evidence implicates exposure to endocrine disrupting chemicals (EDCs) with increased susceptibility to breast cancer. To evaluate the physiological effects of a suspected EDC in vivo, we exposed MCF-7 breast cancer cells and a patient-derived xenograft (PDX, estrogen receptor positive) to physiological levels of methylparaben (mePB), which is commonly used in personal care products as a preservative. mePB pellets (4.4 μg per day) led to increased tumor size of MCF-7 xenografts and ER(+) PDX tumors...
September 1, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27507061/a-novel-approach-to-assessing-bisphenol-a-hazards-using-an-in-vitro-model-system
#6
Md Saidur Rahman, Woo-Sung Kwon, Sung-Jae Yoon, Yoo-Jin Park, Buom-Yong Ryu, Myung-Geol Pang
BACKGROUND: Although the toxicological impacts of the xenoestrogen bisphenol-A (BPA) have been studied extensively, but the mechanism of action is poorly understood. Eventually, no standard method exists for evaluating the possible health hazards of BPA exposure. Considering mice spermatozoa as a potential in vitro model, we investigated the effects of BPA exposure (0.0001, 0.01, 1, and 100 μM for 6 h) on spermatozoa and the related mechanisms of action. The same doses were also employed to evaluate protein profiles of spermatozoa as a means to monitor their functional affiliation to diseases...
August 9, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27386435/the-genotoxic-and-cytotoxic-effects-of-bisphenol-a-bpa-in-mcf-7-cell-line-and-amniocytes
#7
Seyed Mohsen Aghajanpour-Mir, Ebrahim Zabihi, Haleh Akhavan-Niaki, Elahe Keyhani, Iman Bagherizadeh, Sajjad Biglari, Farkhondeh Behjati
Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification. In this study, we investigated the BPA-induced chromosomal damages in MCF-7 cell line, ER-positive and negative amniocyte cells...
2016: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/27312807/preferential-epigenetic-programming-of-estrogen-response-after-in-utero-xenoestrogen-bisphenol-a-exposure
#8
Elisa M Jorgensen, Myles H Alderman, Hugh S Taylor
Bisphenol-A (BPA) is an environmentally ubiquitous estrogen-like endocrine-disrupting compound. Exposure to BPA in utero has been linked to female reproductive disorders, including endometrial hyperplasia and breast cancer. Estrogens are an etiological factor in many of these conditions. We sought to determine whether in utero exposure to BPA altered the global CpG methylation pattern of the uterine genome, subsequent gene expression, and estrogen response. Pregnant mice were exposed to an environmentally relevant dose of BPA or DMSO control...
September 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27203080/total-effective-xenoestrogen-burden-in-serum-samples-and-risk-for-breast-cancer-in-a-population-based-multicase-control-study-in-spain
#9
Roberto Pastor-Barriuso, Mariana F Fernández, Gemma Castaño-Vinyals, Denis Whelan, Beatriz Pérez-Gómez, Javier Llorca, Cristina M Villanueva, Marcela Guevara, José-Manuel Molina-Molina, Francisco Artacho-Cordón, Laura Barriuso-Lapresa, Ignasi Tusquets, Trinidad Dierssen-Sotos, Nuria Aragonés, Nicolás Olea, Manolis Kogevinas, Marina Pollán
BACKGROUND: Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES: We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS: A total of 186 incident pretreatment breast cancer cases and 196 frequency-matched controls were randomly sampled from a large population-based multicase-control study in Spain...
October 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/27038254/bisphenol-a-increases-the-migration-and-invasion-of-triple-negative-breast-cancer-cells-via-oestrogen-related-receptor-gamma
#10
Xiao-Lin Zhang, Na Liu, Shan-Fan Weng, Hong-Sheng Wang
Triple-negative breast cancer (TNBC) is characterized by great metastasis and invasion capability. Our study revealed that nanomolar bisphenol A (BPA), one of the most ubiquitous endocrine disruptors, can increase wound closure and invasion of both MDA-MB-231 and BT-549 cells. BPA treatment can increase protein and mRNA expression of matrix metalloproteinase-2 (MMP-2) and MMP-9, while had no effect on the expression of vimentin (Vim) and fibronectin (FN) in TNBC cells. The expression of G-protein-coupled receptor (GPER), which has been suggested to mediate rapid oestrogenic signals, was not varied in BPA-treated MDA-MB-231 and BT-549 cells...
October 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27026707/the-g-protein-coupled-estrogen-receptor-agonist-g-1-inhibits-nuclear-estrogen-receptor-activity-and-stimulates-novel-phosphoproteomic-signatures
#11
L Cody Smith, Kimberly J Ralston-Hooper, P Lee Ferguson, Tara Sabo-Attwood
Estrogen exerts cellular effects through both nuclear (ESR1 and ESR2) and membrane-bound estrogen receptors (G-protein coupled estrogen receptor, GPER); however, it is unclear if they act independently or engage in crosstalk to influence hormonal responses. To investigate each receptor's role in proliferation, transcriptional activation, and protein phosphorylation in breast cancer cells (MCF-7), we employed selective agonists for ESR1 propyl-pyrazole-triol (PPT), ESR2 diarylpropionitrile (DPN), and GPER (G-1) and also determined the impact of xenoestrogens bisphenol-A (BPA) and genistein on these effects...
June 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/26966408/genetic-polymorphisms-of-insulin-like-growth-factor-1-and-insulin-like-growth-factor-binding-protein-3-xenoestrogen-phytoestrogen-and-premenopausal-breast-cancer
#12
H Li, M Zhao, Q Wang, L Liu, Y N Qi, J Y Li
BACKGROUND: Previous studies suggest a combined effect of insulin-like growth factor 1 (igf-1) and igf binding protein 3 (igfbp-3) gene polymorphisms, xenoestrogen, and phytoestrogen on the igf-1 signalling pathway and serum concentrations in the igf system, which are associated with premenopausal breast cancer (bca) risk. METHODS: Between 2010 and 2012, our study recruited 140 premenopausal bca patients and 160 community-based premenopausal control subjects. Participants were surveyed about oral contraceptive (oc) use, dietary habits, and other bca risk factors...
February 2016: Current Oncology
https://www.readbyqxmd.com/read/26878784/treatment-with-kaempferol-suppresses-breast-cancer-cell-growth-caused-by-estrogen-and-triclosan-in-cellular-and-xenograft-breast-cancer-models
#13
Seung-Hee Kim, Kyung-A Hwang, Kyung-Chul Choi
As a phytoestrogen, kaempferol (Kaem) is one of bioflavonoids, which are found in a variety of vegetables including broccoli, tea and tomato. In this study, the antiproliferative effects of Kaem in triclosn (TCS)-induced cell growth were examined in MCF-7 breast cancer cells. TCS promoted the cell viability of MCF-7 cells via estrogen receptor α (ERα) as did 17β-estradiol (E2), a positive control. On the other hand, Kaem significantly suppressed E2 or TCS-induced cell growth. To elucidate the molecular mechanisms of TCS and Kaem, alterations in the expressions of cell cycle, apoptosis and metastasis-related genes were identified using western blot assay...
February 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/26821503/-bisphenol-a-an-infamous-molecule
#14
EDITORIAL
Aharona Gutman, Yehuda Shoenfeld
Bisphenol A (BPA) is a monomer found in plastic products used daily for the storage and consumption of food and beverages, such as plastic bottles, containers, and even toys. The molecule leaches out into the food, increasingly if exposed to warm temperatures and high acidity. BPA is known for many negative effects on the human body; for instance it acts as an xenoestrogen and influences fertility and gestation and might also have carcinogenic effects, causing breast and prostate cancer. Although it has not yet been proven as a direct cause of autoimmunity, many of the effects of BPA can be related to the pathogenesis of autoimmune disease (AID)...
November 2015: Harefuah
https://www.readbyqxmd.com/read/26502914/parabens-and-human-epidermal-growth-factor-receptor-ligand-cross-talk-in-breast-cancer-cells
#15
Shawn Pan, Chaoshen Yuan, Abderrahmane Tagmount, Ruthann A Rudel, Janet M Ackerman, Paul Yaswen, Chris D Vulpe, Dale C Leitman
BACKGROUND: Xenoestrogens are synthetic compounds that mimic endogenous estrogens by binding to and activating estrogen receptors. Exposure to estrogens and to some xenoestrogens has been associated with cell proliferation and an increased risk of breast cancer. Despite evidence of estrogenicity, parabens are among the most widely used xenoestrogens in cosmetics and personal-care products and are generally considered safe. However, previous cell-based studies with parabens do not take into account the signaling cross-talk between estrogen receptor α (ERα) and the human epidermal growth factor receptor (HER) family...
May 2016: Environmental Health Perspectives
https://www.readbyqxmd.com/read/26337277/role-of-er-%C3%AE-36-in-breast-cancer-by-typical-xenoestrogens
#16
REVIEW
Jun Liu, Zhixiang Xu, Xiaodong Ma, Bin Huang, Xuejun Pan
About 10 years have passed since the discovery of the estrogen receptor subtype, estrogen receptor alpha 36 (ER-α36). The relationship between cancerous cells and ER-α36 in mediating xenoestrogens (XEs) is a significant issue in the progression and treatment of breast cancer. XEs can combine with classical estrogen receptors and other receptor subtypes especially ER-α36, resulting in activation of nongenomic pathways as well as genomic pathways. Recently, most laboratories have focused on further study into the rapidly nongenomic mechanisms by overexpressing or knocking down ER-α36 in breast cancer cell lines...
September 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26260748/genistein-reduces-the-noxious-effects-of-in-utero-bisphenol-a-exposure-on-the-rat-prostate-gland-at-weaning-and-in-adulthood
#17
COMPARATIVE STUDY
Bruna Dias Bernardo, Joyce Zalotti Brandt, Tony Fernando Grassi, Lívia Teresa R Silveira, Wellerson Rodrigo Scarano, Luis Fernando Barbisan
Bisphenol A (BPA) is one hormonally active chemical with potential deleterious effects on reproductive organs, including breast and prostate. In contrast, genistein (GEN) is the major phytoestrogen of soy that presents potential protective effects against hormone-dependent cancers, including that of the prostate. Thus, pregnant Sprague-Dawley rats were treated with BPA at 25 or 250 μg/kg/day by gavage from gestational day (GD) 10-21 with or without dietary GEN at 250 mg/kg/chow (∼5.5 mg/kg/day). Then, male offspring from different litters were euthanized on post-natal day (PND) 21 and 180...
October 2015: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/26079774/ddt-exposure-in-utero-and-breast-cancer
#18
Barbara A Cohn, Michele La Merrill, Nickilou Y Krigbaum, Gregory Yeh, June-Soo Park, Lauren Zimmermann, Piera M Cirillo
CONTEXT: Currently no direct evidence links in utero dichlorodiphenyltrichloroethane (DDT) exposure to human breast cancer. However, in utero exposure to another xenoestrogen, diethylstilbestrol, predicts an increased breast cancer risk. If this finding extends to DDT, it could have far-reaching consequences. Many women were heavily exposed in utero during widespread DDT use in the 1960s. They are now reaching the age of heightened breast cancer risk. DDT exposure persists and use continues in Africa and Asia without clear knowledge of the consequences for the next generation...
August 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25804877/risk-of-female-breast-cancer-and-serum-concentrations-of-organochlorine-pesticides-and-polychlorinated-biphenyls-a-case-control-study-in-tunisia
#19
Juan P Arrebola, Hidaya Belhassen, Francisco Artacho-Cordón, Ridha Ghali, Hayet Ghorbel, Hamouda Boussen, Francisco M Perez-Carrascosa, José Expósito, Abderrazek Hedhili, Nicolás Olea
The aim of this study was to investigate the association between serum concentrations of a group of organochlorine pesticides/polychlorinated biphenyls with xenoestrogenic potential and the risk of breast cancer in a female population from Tunisia. The relationship between serum levels of the pollutants and the risk of cancer was assessed using logistic regression analyses. In the unadjusted models, β-hexachlorocyclohexane (β-HCH), hexachlorobenzene, heptachlor, polychlorinated biphenyl congeners 138, 153, and 180, and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were positively associated with breast cancer risk...
July 1, 2015: Science of the Total Environment
https://www.readbyqxmd.com/read/25760782/residential-exposure-to-estrogen-disrupting-hazardous-air-pollutants-and-breast-cancer-risk-the-california-teachers-study
#20
Ruiling Liu, David O Nelson, Susan Hurley, Andrew Hertz, Peggy Reynolds
BACKGROUND: Some studies show increased breast cancer risk from exposure to xenoestrogens, but few have explored exposures via ambient air, which could impact large populations. OBJECTIVES: This study explored the association between breast cancer risk and residential exposures to ambient estrogen disruptors among participants in a large cohort study, the California Teachers Study. METHODS: Participants consisted of 112,379 women free of breast cancer and living at a California address in 1995/1996...
May 2015: Epidemiology
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