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cancer and Xenoestrogens

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https://www.readbyqxmd.com/read/29348811/disconnecting-the-estrogen-receptor-binding-properties-and-antimicrobial-properties-of-parabens-through-3-5-substitution
#1
Bridget L Bergquist, Kaelyn G Jefferson, Hailey N Kintz, Amorette E Barber, Andrew A Yeagley
Commercially utilized parabens are employed for their antimicrobial properties, but a weak binding to the estrogen receptor alpha (ERα) may lead to breast cancer in some applications. Modification of the paraben scaffold should allow for a disconnection of these observed properties. Toward this goal, various 3,5-substituted parabens were synthesized and assessed for antimicrobial properties against S. aureus as well as competitive binding to the ERα. The minimum inhibitory concentration assay confirmed retention of antimicrobial activity in many of these derivatives, while all compounds exhibited decreased xenoestrogen activity as determined by a combination of competitive enzyme linked immunosorbent assay (ELISA), proliferation, and estrogen receptor binding assay...
January 11, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29337187/metabolomics-reveals-that-dietary-xenoestrogens-alter-cellular-metabolism-induced-by-palbociclib-letrozole-combination-cancer-therapy
#2
Benedikt Warth, Philipp Raffeiner, Ana Granados, Tao Huan, Mingliang Fang, Erica M Forsberg, H Paul Benton, Laura Goetz, Caroline H Johnson, Gary Siuzdak
Recently, the palbociclib/letrozole combination therapy was granted accelerated US FDA approval for the treatment of estrogen receptor (ER)-positive breast cancer. Since the underlying metabolic effects of these drugs are yet unknown, we investigated their synergism at the metabolome level in MCF-7 cells. As xenoestrogens interact with the ER, we additionally aimed at deciphering the impact of the phytoestrogen genistein and the estrogenic mycotoxin zearalenone. A global metabolomics approach was applied to unravel metabolite and pathway modifications...
January 10, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29317319/the-molecular-mechanisms-of-action-of-the-endocrine-disrupting-chemical-bisphenol-a-in-the-development-of-cancer
#3
REVIEW
Ayman E Shafei, Maggie M Ramzy, Abdelhares I Hegazy, Ahmed K Husseny, Usama G El-Hadary, Mazen M Taha, Ali A Mosa
The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways...
January 6, 2018: Gene
https://www.readbyqxmd.com/read/29310425/treatment-with-phytoestrogens-reversed-triclosan-and-bisphenol-a-induced-anti-apoptosis-in-breast-cancer-cells
#4
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
Triclosan (TCS) and bisphenol A (BPA) are endocrine-disrupting chemicals that interfere with the hormone or endocrine system and may cause cancer. Kaempferol (Kaem) and 3,3'-diindolylmethane (DIM) are phytoestrogens that play chemopreventive roles in the inhibition of carcinogenesis and cancer progression. In this study, the influence of TCS, BPA, Kaem, and DIM on proliferation and apoptotic abilities of VM7Luc4E2 breast cancer cells were examined. MTT assay revealed that TCS (0.1-10 μM), BPA (0.1-10 μM) and E2 (0...
January 9, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29237712/receptor-activities-of-persistent-pollutant-serum-mixtures-and-breast-cancer-risk
#5
Maria Wielsøe, Christian Bjerregaard-Olesen, Peder Kern, Eva Cecilie Bonefeld-Jørgensen
Studies on associations between persistent organic pollutants (POPs) and breast cancer risk are inconclusive. The majority of studies have evaluated the effect of single compounds, without considering multiple exposures to and interactions between different POPs. The present study aimed at evaluating breast cancer risk related to combined effects of serum POP mixtures on cellular receptor functions. Data on breast cancer cases (n=77) and controls (n=84) was collected among Greenlandic Inuit women. Serum mixtures of lipophilic POPs (lipPOPs), perfluoroalkyl acids (PFAAs), and dioxin-like POPs were extracted...
December 13, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29050248/low-dose-of-bisphenol-a-enhance-the-susceptibility-of-thyroid-carcinoma-stimulated-by-dhpn-and-iodine-excess-in-f344-rats
#6
Jing Zhang, Xiaochen Zhang, Yanan Li, Zhenzhen Zhou, Chuanlong Wu, Zhiyan Liu, Lanxiang Hao, Shanshan Fan, Fang Jiang, Yan Xie, Ling Jiang
Thyroid carcinoma (TC) is the most common endocrine neoplasm. The risk of TC as a second primary malignancy (SPM) of breast cancer is significantly increased. Bisphenol A (BPA) is a widely contacted xenoestrogen and increases susceptibility to breast cancer through binding to estrogen receptor alpha (ERα). However, the effect of BPA on thyroid carcinogenesis has not been fully demonstrated. This present study aimed to characterize the effects of BPA on the development of TC using a Fischer 344 (F344) rat model...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965971/combined-low-dose-zearalenone-and-aflatoxin-b1-on-cell-growth-and-cell-cycle-progression-in-breast-cancer-mcf-7-cells
#7
Ka Yiu Yip, Murphy Lam Yim Wan, Alice Sze Tsai Wong, Kenneth S Korach, Hani El-Nezami
Zearalenone (ZEA) has long been recognized as a xenoestrogen, while the endocrine disrupting effects of aflatoxin B1 (AFB1) have been identified recently. Due to co-occurrence and endocrine disrupting potentials of ZEA and AFB1, it was hypothesized that co-exposure to ZEA and AFB1 might affect breast cancer cell growth. Consequently, the aim of this study was to evaluate the combined effects of ZEA and AFB1 (1nM-100nM) on cell growth and cell cycle progression, using a human breast cancer cell line MCF-7. Our results showed that ZEA and AFB1 produced significant interactive effects on cell growth, DNA synthesis and cell cycle progression...
November 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28855101/in-vitro-observations-and-in-silico-predictions-of-xenoestrogen-mixture-effects-in-t47d-based-receptor-transactivation-and-proliferation-assays
#8
Nina Schlotz, Gwang-Jin Kim, Stefan Jäger, Stefan Günther, Evelyn Lamy
Within endocrine disruptor research, evaluation and interpretation of mixture effects and the predictive value for downstream responses still warrant more in-depth investigations. We used an estrogen receptor (ER)-mediated reporter gene assay (ER-CALUX®) and a cell proliferation assay (WST-1 assay), both based on the T47D breast cancer cell line, to test mixtures of heterogeneous xenoestrogens. Observed concentration-response curves were compared to those predicted by the concepts of concentration addition (CA), generalized concentration addition (GCA), and a novel full logistic model (FLM)...
December 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28763032/a-chip-for-estrogen-receptor-action-detection-of-biomarkers-released-by-mcf-7-cells-through-estrogenic-and-anti-estrogenic-effects
#9
Konstanze Gier, Claudia Preininger, Ursula Sauer
The fluorescence-based multi-analyte chip platform for the analysis of estrogenic and anti-estrogenic substances is a new in vitro tool for the high throughput screening of environmental samples. In contrast to existing tools, the chip investigates the complex action of xenoestrogens in a human cell model by characterizing protein expression. It allows for the quantification of 10 proteins secreted by MCF-7 cells, representing various biological and pathological endpoints of endocrine action and distinguishing between estrogen- and anti-estrogen-dependent secretion of proteins...
August 1, 2017: Sensors
https://www.readbyqxmd.com/read/28717100/inhibitory-modulation-of-human-estrogen-receptor-%C3%AE-and-%C3%AE-activities-by-dicyclohexyl-phthalate-in-human-breast-cancer-cell-lines
#10
Hiroyuki Okazaki, Shuso Takeda, Saki Matsuo, Masaya Matsumoto, Erika Furuta, Eriko Kohro-Ikeda, Hironori Aramaki
Phthalate esters (PAEs) are man-made compounds that are used widely in industry, and the ubiquitous exposure of humans to PAEs has been reported. Although some PAEs have been suggested to function as xenoestrogens in in vitro systems, such as human estrogen receptors (ERs) expressed in Chinese hamster ovary (CHO)-K1 cells, few studies have attempted to elucidate whether PAEs affect human ERα/ERβ-mediated signaling in human breast cancer cells (i.e., combination between human ERs and human cells). Thus, further experiments are needed in order to clarify the activities of PAEs...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28703301/the-xenoestrogens-biphenol-a-and-nonylphenol-differentially-regulate-metalloprotease-mediated-shedding-of-egfr-ligands
#11
Paulina Urriola-Muñoz, Xue Li, Thorsten Maretzky, David R McIlwain, Tak W Mak, Juan G Reyes, Carl P Blobel, Ricardo D Moreno
The xenoestrogens bisphenol-A (BPA) and nonylphenol (NP) are endocrine disruptors used in the plastic polymer industry to manufacture different products for human use. Previous studies have suggested a role of these compounds in the shedding of signaling molecules, such as tumor necrosis factor α (TNF-α). The aim of this work was to evaluate the effect of BPA and NP on the sheddase ADAM17 and its newly discovered regulators iRhom1 and iRhom2 in the release of EGFR-ligands. We report that BPA and NP can stimulate the release of the ADAM17-substrates HB-EGF and TGF-α...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28549265/facile-screening-of-potential-xenoestrogens-by-an-estrogen-receptor-based-reusable-optical-biosensor
#12
Lanhua Liu, Xiaohong Zhou, Yun Lu, Didi Shan, Bi Xu, Miao He, Hanchang Shi, Yi Qian
The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of screening xenoestrogens. We reported an estrogen receptor (ER)-based reusable fiber biosensor for facile screening estrogenic compounds in environment. The bioassay is based on the competition of xenoestrogens with 17β-estradiol (E2) for binding to the recombinant receptor of human estrogen receptor α (hERα) protein, leaving E2 free to bind to fluorophore-labeled anti-E2 monoclonal antibody...
May 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28521190/simultaneous-determination-of-bisphenol-a-and-estrogens-in-hair-samples-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#13
Chaelin Lee, Chong Hyeak Kim, Sunghwan Kim, Sung-Hee Cho
Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28288811/changes-in-the-total-effective-xenoestrogen-burden-texb-of-breast-cancer-patients-during-an-18-month-post-surgical-follow-up
#14
Mariana F Fernandez, Jose Pumarega, Miquel Porta, Jose Manuel Molina-Molina, Juan P Arrebola, Nicolas Olea
We aimed to assess changes in the total effective xenoestrogen burden (TEXB) -a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women...
March 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28263720/simvastatin-down-regulates-differential-genetic-profiles-produced-by-organochlorine-mixtures-in-primary-breast-cell-hmec
#15
LETTER
Javier Rivero, Luis Alberto Henríquez-Hernández, Luis D Boada, Jose Pestano, Octavio P Luzardo, María Camacho, Manuel Zumbado, Pilar F Valerón
Women all over the world are exposed to an unavoidable contamination by organochlorine pesticides and other chemical pollutants. Many of them are considered as xenoestrogens and have been associated with the development and progression of breast cancer. We have demonstrated that the most prevalent pesticide mixtures found in healthy women and in women diagnosed with breast cancer modulates the gene expression in human epithelial mammary cells. Statins are well-known cholesterol-depleting agents acting as inhibitors of cholesterol synthesis...
April 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28078498/perinatal-exposure-to-bisphenol-a-or-diethylstilbestrol-increases-the-susceptibility-to-develop-mammary-gland-lesions-after-estrogen-replacement-therapy-in-middle-aged-rats
#16
Ayelen L Gomez, Melisa B Delconte, Gabriela A Altamirano, Lucia Vigezzi, Veronica L Bosquiazzo, Luís F Barbisan, Jorge G Ramos, Enrique H Luque, Mónica Muñoz-de-Toro, Laura Kass
The development of the mammary gland is a hormone-regulated event. Several factors can dysregulate its growth and make the gland more susceptible to cellular transformation. Among these factors, perinatal exposure to xenoestrogens and hormone replacement therapy has been associated with increased risk of developing breast cancer. Here, we assessed the effects induced by estrogen replacement therapy (ERT) in ovariectomized (OVX) middle-aged rats and whether perinatal exposure to diethylstilbestrol (DES) or bisphenol A (BPA) modified these effects in the mammary gland...
April 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/27902959/kaempferol-a-phytoestrogen-suppressed-triclosan-induced-epithelial-mesenchymal-transition-and-metastatic-related-behaviors-of-mcf-7-breast-cancer-cells
#17
Geum-A Lee, Kyung-Chul Choi, Kyung-A Hwang
As a phytoestrogen, kaempferol is known to play a chemopreventive role inhibiting carcinogenesis and cancer progression. In this study, the influences of triclosan, an anti-bacterial agent recently known for an endocrine disrupting chemical (EDC), and kaempferol on breast cancer progression were examined by measuring their effects on epithelial-mesenchymal transition (EMT) and metastatic-related behaviors of MCF-7 breast cancer cells. Morphological changes of MCF-7 cells were observed, and a wound-healing assay was performed after the treatment of triclosan and kaempferol...
January 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27863841/the-role-and-impact-of-estrogens-and-xenoestrogen-on-the-development-of-cervical-cancer
#18
REVIEW
Dorota Ewa Bronowicka-Kłys, Margarita Lianeri, Paweł Piotr Jagodziński
Throughout an individual's lifetime, the human body is exposed to many different chemical compounds, including xenoestrogens (XEs) that can be found in the environment, food, air, cosmetics and other substances, which have a positive or negative impact on their health and lifestyle. Whereas high-risk human papillomavirus (HR-HPV) is necessary but not sufficient for full malignant cervical cell transformation, other compounds such as estrogens and XEs may be risk factors for cervical cancer (CC) development...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27816767/xenoestrogen-regulation-of-er%C3%AE-er%C3%AE-balance-in-hormone-associated-cancers
#19
Filippo Acconcia, Marco Fiocchetti, Maria Marino
The hormone 17β-estradiol (E2) contributes to body homeostasis maintenance by regulating many different physiological functions in both male and female organs. E2 actions in reproductive and non-reproductive tissues rely on a complex net of nuclear and extra-nuclear signal transduction pathways triggered by at least two estrogen receptor subtypes (ERα and ERβ). Consequently, the de-regulation of E2:ER signaling contributes to the pathogenesis of many diseases including cancer. Among other factors, the ERα/ERβ ratio is considered one of the pivotal mechanisms at the root of E2 action in cancer progression...
November 2, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27628920/breast-cancer-and-persistent-organic-pollutants-excluding-ddt-a-systematic-literature-review
#20
REVIEW
Tafzila Akter Mouly, Leisa-Maree Leontjew Toms
Persistent organic pollutants (POPs) are a group of heterogeneous compounds of both natural and anthropogenic origin with highly persistent and bioaccumulative properties. They cause a range of adverse effects to human health and the environment around the world. There is growing concern that POPs may increase breast cancer risk due to their xenoestrogenic properties. The aim of this systematic literature review is to summarize and integrate the risks of breast cancer following environmental exposure to POPs (other than DDT) from primary epidemiological studies published between 2006 and 2015...
November 2016: Environmental Science and Pollution Research International
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