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"posterior reversible leukoencephalopathy syndrome"

Fumi Kobayashi, Hidetaka Kato, Miki Suzuki, Ryosuke Usui, Minako Koike, Takashi Ohashi
A 23-year-old woman presented with disturbance of consciousness and seizure. Her blood pressure was remarkably high, and brain magnetic resonance imaging (MRI) showed high-intensity T2 signals in the bilateral basal ganglia, corpus callosum, cerebral white matter, and cortex. With the administration of angiotensin II receptor blocker, the symptoms and MRI findings improved, along with normalization of blood pressure, and a diagnosis of posterior reversible leukoencephalopathy syndrome (PRES) was made. Plasma renin activity was high, and the right kidney was severely atrophic...
September 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
Mariam Mathew, Ayesha Salahuddin, Namitha R Mathew, Ramachandiran Nandhagopal
Postpartum headache is described as headache and neck or shoulder pain during the first 6 weeks after delivery. Common causes of headache in the puerperium are migraine headache and tension headache; other causes include pre-eclampsia/eclampsia, post-dural puncture headache, cortical vein thrombosis, subarachnoid hemorrhage, posterior reversible leukoencephalopathy syndrome, brain tumor, cerebral ischemia, meningitis, and so forth. Idiopathic intracranial hypertension (IIH) is a rare cause of postpartum headache...
January 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Ahmad K Rahal, Phu V Truong, K James Kallail
Oxaliplatin is a common chemotherapy drug used for colon and gastric cancers. Common side effects are peripheral neuropathy, hematological toxicity, and allergic reactions. A rare side effect is seizures which are usually associated with posterior reversible leukoencephalopathy syndrome (PRES). A 50-year-old male patient presented with severe abdominal pain. CT scan of the abdomen showed acute appendicitis. Appendectomy was done and pathology showed mixed adenoneuroendocrine carcinoma. Adjuvant chemotherapy was started with Folinic acid, Fluorouracil, and Oxaliplatin (FOLFOX)...
2015: Case Reports in Oncological Medicine
Melek Karakurt Eryılmaz, Hasan Mutlu, Derya Kıvrak Salim, Fatma Yalçın Musri, Hasan Şenol Coşkun
Posterior reversible leukoencephalopathy syndrome (PRES) is a syndrome characterized by headache, hypertension, confusion, visual disturbance, and seizures accompanied by subcortical vasogenic edema, predominantly involving the parietal and occipital lobes. The syndrome is usually described in malignant hypertension, eclampsia, renal failure, immunosuppressive, and cytotoxic chemotherapies. Bevacizumab, a monoclonal antibody that binds to the vascular endothelial growth factor (VEGF) has been linked to PRES...
October 13, 2015: Journal of Oncology Pharmacy Practice
Uluç Yiş, Pakize Karaoğlu, Semra Hız Kurul, Alper Soylu, Handan Çakmakçi, Salih Kavukçu
We report the youngest pediatric case of posterior reversible leukoencephalopathy syndrome confined to brainstem and spinal cord. At presentation bicytopenia, renal derangement, visual disturbances, magnetic resonance imaging findings, increased protein content, IgG index and cell count in the cerebrospinal fluid led us to extensive search for myelitis. She received a short course of steroid treatment. The final diagnosis was hypertension due to reflux nephropathy. Severe hypertension that exceeds the range of autoregulation in anterior spinal territory may result in spinal posterior reversible leukoencephalopathy syndrome...
January 2016: Brain & Development
Pranav Parikh, Danielle Duhame, Laura Monahan, Robert Woroniecki
BACKGROUND: Hyponatremic hypertensive syndrome (HHS) is an uncommon disorder usually encountered in the adult population with unilateral renal artery stenosis and is under-recognized in the pediatric population. CASE DIAGNOSIS/TREATMENT: A 19-month-old male presented with new-onset status epilepticus associated with neurological sequelae, and hypertension to a high of 248/150 mmHg. Lab work revealed significant hyponatremia, elevated peripheral renin activity, and increase in aldosterone and ADH levels...
2015: Frontiers in Pediatrics
N Yafour, A Krim, R Bouhass, M A Bekadja
No abstract text is available yet for this article.
March 2016: Hematology/oncology and Stem Cell Therapy
David Haughey, Sriram S Narsipur
BACKGROUND: Posterior reversible leukoencephalopathy syndrome (PRES) is characterized by an acute neurologic dysfunction coupled with characteristic findings on brain imaging. PRES occurs in the setting of hypertensive emergencies, eclampsia and as a neurotoxic effect of immunosuppressive agents. While overwhelmingly reversible without residual deficits when promptly recognized, vague symptomatology may delay the diagnosis of PRES. RESULTS/SUMMARY: A 50-year-old man who had undergone a recent kidney transplant was admitted to our clinic due to multiple episodes of seizure...
January 2015: Case Reports in Nephrology and Dialysis
A Jaiswal, I Sabnani, D A Baran, M J Zucker
Rituximab is commonly used as a first line therapy to treat posttransplant lymphoproliferative disorders (PTLDs). It has also proved useful in the management of refractory antibody mediated graft rejection. We report an unusual case in which a heart transplant recipient being treated with rituximab for PTLD developed altered mental status, hallucinations and visual symptoms and magnetic resonance imaging (MRI) findings of symmetrical enhancement suggestive of posterior reversible leukoencephalopathy syndrome (PRES)...
March 2015: American Journal of Transplantation
Yasmin Leshem, Shlomit Fennig, Elisa Talianski, Gahl Greenberg, Ido Wolf
Posterior reversible leukoencephalopathy syndrome [PRES] is characterized by a symmetrical brain edema. It is rarely caused by chemotheraphy. While steroids can lead to deterioration in the condition of a PRES patient, they are still the drug of choice for the more common condition of brain edema secondary to metastases. We describe the case of a colon cancer patient who underwent adjuvant treatment with capecitabine and oxaliplatin and was admitted to the hospital with seizures and brain edema. On admission, the condition was attributed to brain metastases and hence a high dose steroid treatment was initiated...
November 2014: Harefuah
Upasana Vrijlal Patel, Nirajkumar Jagjivan Patel
Rapidly progressing glomerulonephritis like microscopic polyangiitis and allergic granulomatous angiitis are among the common presentations of perinuclear antineutrophilic cytoplasmic antibody (p-ANCA) vasculitis. Involvement of central nervous system is rare in contrast to mononeuritis multiplex, which is a well-known neurological manifestation of this condition. We report a case presented with uraemic encephalopathy and posterior reversible encephalopathy syndrome (PRES)-related symptoms, which showed recovery after haemodialysis although PRES with seizures recurred later...
2014: BMJ Case Reports
C Andrew Kistler, Joseph Caleb McCall, Saad Sultan Ghumman, Ijlal Akbar Ali, Ali A Siddiqui
Posterior reversible encephalopathy syndrome (PRES) is a rare complication of transarterial chemoembolization (TACE) used to treat liver metastases and has never been reported in a patient with metastatic uveal melanoma (UM) to the liver. We report the first case of PRES secondary to TACE with drug eluting beads (DEBs) loaded with doxorubicin in a 56-year-old woman with metastatic UM to the liver.
April 2014: Journal of Gastrointestinal Oncology
Faruk İncecik, M Özlem Hergüner, Dinçer Yıldızdaş, Mustafa Yılmaz, Gülen Mert, Özden O Horoz, Şakir Altunbaşak
Posterior reversible leukoencephalopathy syndrome (PRES) is a recently described disorder with typical radiological findings of bilateral grey and white matter abnormalities in the posterior regions of the cerebral hemispheres. It has been described in children in association with some medications, renal disease, autoimmune disease, transplantation, and sepsis. In this report, we discuss an eight-year-old boy with PRES during pulse methylprednisolone therapy. In conclusion, PRES is a neurological complication of pulse methylprednisolone therapy, which responds favorably to prompt therapy withdrawal and blood pressure control...
July 2013: Turkish Journal of Pediatrics
John H Pula, Angela M Kao, Jorge C Kattah
PURPOSE OF REVIEW: Systemic medications may cause side-effects manifesting primarily as neuro-ophthalmologic problems. It is paramount for the physician to be updated on both well recognized and novel associations between drugs and their potential adverse reactions. RECENT FINDINGS: There is a growing list of medications that can cause pupil dilation, pupil constriction, dyschromatopsia, worsening of ocular myasthenia gravis, posterior reversible leukoencephalopathy syndrome, pseudotumor cerebri, disturbances in eye movements, accommodation problems, or optic neuropathy...
November 2013: Current Opinion in Ophthalmology
Partha S Ghosh, Charles Kwon, Melanie Klein, Julie Corder, Debabrata Ghosh
We reviewed neurologic complications after renal transplantation in children over a 20-year period. Neurologic complications were classified as early (within 3 months) and delayed (beyond 3 months). Of 115 children, 10 (8.7%) had complications. Early complications were found in 4.35% of patients: seizures in 4 (posterior reversible leukoencephalopathy syndrome due to immunosuppressant toxicity, sepsis/presumed meningitis, and indeterminate) and headaches in 1. One patient with seizures received levetiracetam for 6 months and 1 with headaches received amitriptyline prophylaxis...
June 2014: Journal of Child Neurology
Robert Foerster, Thomas Welzel, Juergen Debus, Carsten Gruellich, Dirk Jaeger, Karin Potthoff
A 62-year-old female patient with metastatic renal cell carcinoma under third-line treatment with pazopanib for 8 weeks suddenly developed severe headaches, grand mal seizures and paresis of the left arm in combination with gait instability as well as nausea and vomiting during her vacation abroad. The emergency physician measured systolic blood pressure values over 300 mm Hg and suspected a stroke. The CT imaging without contrast agent in a local hospital did not show any pathologic findings despite bone metastases...
January 2013: Case Reports in Oncology
Raghvendra Thakur, Bhoj Raj Sharma, Tian Yuan, Zheng Guiying
Posterior reversible leukoencephalopathy syndrome (PRLS) is a neurologic condition, often presents with various clinical manifestations. It is rare during pregnancy. We herein report a case of PRLS in a 31-year-old woman, presented with preeclampsia, diagnosed by computer tomography, and successfully delivered the baby with caesarean section. At discharge, patient was fully recovered without any complication.
2013: Case Reports in Obstetrics and Gynecology
Vivien H Lee, Richard E Temes, Sayona John, James J Conners, Thomas Bleck, Shyam Prabhakaran
BACKGROUND: We report a case of global cerebral edema and herniation due to Posterior Reversible Leukoencephalopathy Syndrome (PRES). METHODS: Case report. RESULTS: A 37-year-old healthy female developed persistent severe occipital headache, and after 1 month of persistent headache, developed an episode of loss of consciousness. CT brain showed diffuse cerebral edema and effacement of the sulci and basal cisterns. Her initial neurological examination was nonfocal but with severe headache...
February 2013: Neurocritical Care
Harmanjot Kaur Grewal, Lesley Ann Saketkoo, Ignacio Garcia-Valladares, Luis Rolan Espinoza
No abstract text is available yet for this article.
August 2012: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Ioannis Karakis, James A Macdonald, Maria Stefanidou, Carlos S Kase
BACKGROUND: The "posterior reversible leukoencephalopathy" syndrome, generally observed in the setting of severe, acute hypertension, often correlates with radiological abnormalities that involve the occipital lobes and other hemispheric areas. A predominant involvement of the brainstem in this syndrome is rare. PATIENTS: We report three patients with previously known or newly diagnosed severe hypertension, who presented with a combination of headache and visual disturbances, along with diffuse abnormalities demonstrated on magnetic resonance imaging in the brainstem and cerebellum...
April 2009: Journal of Vascular and Interventional Neurology
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