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https://www.readbyqxmd.com/read/29141255/is-venlafaxine-more-effective-than-escitalopram-and-nortriptyline-in-the-management-of-painful-symptoms-in-patients-with-major-depression
#1
Jan Jaracz, Karolina Gattner, Krystyna Jaracz, Krystyna Górna, Jerzy Moczko, Joanna Hauser
Background Conflicting data regarding the efficacy of antidepressants of different mechanism of action on unexplained painful physical symptoms (UPPS) in depression have been published so far. Objective The aim of this study was to compare the impact of escitalopram (ESC), nortriptyline (NOR), and venlafaxine (VEN) on UPPS in patients with major depression. Materials and methods Sixty patients, participants in the GENDEP study, with a diagnosis of depression according to the ICD-10 criteria were randomly assigned to treatment with ESC (10-30 mg, mean dose 15...
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29106712/investigation-of-ph-effect-on-cationic-solute-binding-to-keratin-and-partition-to-hair
#2
Lingyi Li, Senpei Yang, Tao Chen, Lujia Han, Guoping Lian
OBJECTIVE: In the process of hair treatment, various cationic actives contained in hair care products can be absorbed into hair fiber to modulate the physicochemical properties of hair such as color, strength, style and volume. There have been very limited studies on the binding and partition properties of hair care actives to hair. This study aimed to investigate the pH effects on cationic solute absorption into hair and binding to keratin. METHODS: The keratin binding and hair partition properties of three cationic solutes (theophylline, nortriptyline and amitriptyline) have been measured at different pH using fluorescence spectroscopy and equilibrium absorption experiment...
November 6, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29083873/direct-analysis-of-free-aqueous-and-organic-operational-solutions-as-a-tool-for-understanding-fundamental-principles-of-electromembrane-extraction
#3
Andrea Šlampová, Pavel Kubáň
Aqueous and organic phases in microelectromembrane extraction (μ-EME) were formed as adjacent plugs of free immiscible solutions in narrow-bore polymeric tubing, and each single phase was recovered and analyzed after μ-EME. A three-phase μ-EME setup was employed for investigation of time-dependent distribution of model basic drugs among aqueous and organic phases. Exact concentrations of nortriptyline and papaverine in donor solution, acceptor solution, and free liquid membrane (FLM) were determined by capillary electrophoresis with ultraviolet detection (CE-UV)...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29075117/need-for-medication-to-complement-catecholamines-in-smoking-cessation-of-hardcore-smokers
#4
Atsuko Kawai, Masatake Kurita, Satoshi Nishino, Eishin Hirata, Tadahiro Sato, Yoshiro Okubo
Many smokers find it difficult to stop smoking without assistance. The antidepressants bupropion and nortriptyline can aid smoking cessation. The main aim of this study was to understand the pathophysiology of smoking cessation better based on biological backgrounds. We investigated the following biological markers for any alterations during smoking cessation in the absence of pharmacotherapy: the dopamine metabolite homovanillic acid (HVA), the noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and brain-derived neurotrophic factor (BDNF)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29065085/resolution-of-persistent-post-stapedotomy-vertigo-with-migraine-prophylactic-medication
#5
Omid Moshtaghi, Hossein Mahboubi, Yarah M Haidar, Ronald Sahyouni, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: To describe persistent post-stapedotomy vertigo (PSV) and its treatment using migraine prophylaxis. PATIENTS: A retrospective review of all patients with persistent PSV spanning 10 years at a tertiary academic hospital was performed. Patients who experienced persistent vertigo for a minimum of 3 months after surgery were included. Those with possible perilymph fistula, long prosthesis, and benign paroxysmal positional vertigo were excluded. INTERVENTIONS: All patients received instructions on migraine dietary and lifestyle changes and Vitamin B2 and magnesium...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29053849/a-network-meta-analysis-comparing-effects-of-various-antidepressant-classes-on-the-digit-symbol-substitution-test-dsst-as-a-measure-of-cognitive-dysfunction-in-patients-with-major-depressive-disorder
#6
Bernhard T Baune, Mélanie Brignone, Klaus Groes Larsen
Background: Major depressive disorder (MDD) is a common condition that often includes cognitive dysfunction. A systematic literature review of studies and a network meta-analysis (NMA) were carried out to assess the relative effect of antidepressants on cognitive dysfunction in MDD. Methods: MEDLINE ®, Embase ®, Cochrane, CDSR, PsychINFO ® databases, clinical trial registries, and relevant conference abstracts were searched for randomised controlled trials (RCTs) assessing the effects of antidepressants/placebo on cognition...
October 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29033248/use-of-oral-antidepressants-in-patients-with-chronic-pruritus-a-systematic-review
#7
Tessa A Kouwenhoven, Peter C M van de Kerkhof, Marijke Kamsteeg
BACKGROUND: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants. OBJECTIVE: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. METHODS: The PubMed, EMBASE, Cochrane, and Web of Science databases were searched...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28991969/photosensitized-degradation-of-amitriptyline-and-its-active-metabolite-nortriptyline-in-aqueous-fulvic-acid-solution
#8
Yong Chen, Jianfeng Liang, Lu Liu, Xiye Lu, Jianwu Deng, Ivan P Pozdnyakov, Yuegang Zuo
Amitriptyline is a frequently prescribed tricyclic antidepressant. Although amitriptyline and its active metabolite, nortriptyline, have been widely detected in natural waters, their environmental fate due to photodegradation is poorly understood. Here we describe a study conducted to investigate the photodegradation of amitriptyline and its active metabolite under simulated sunlight. Neither amitriptyline nor nortriptyline underwent direct photodegradation, but rapid photosensitized degradation did occur in fulvic acid (FA) solutions...
September 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28985320/multiple-drug-toxicity-involving-novel-psychoactive-substances-3-fluorophenmetrazine-and-u-47700
#9
Kayla N Ellefsen, Elizabeth A Taylor, Paul Simmons, Vickie Willoughby, Brad J Hall
3-Fluorophenmetrazine (3-FPM) is a stimulant-like novel psychoactive substance (NPS) and fluorinated analog of phenmetrazine that has recently appeared on the recreational drug market, with limited published information. Likewise, the synthetic opioid U-47700 has gained popularity among recreational drug users and is frequently detected in postmortem casework. We present the case history, autopsy and toxicological findings of a fatality involving the designer drugs 3-FPM and U-47700 for the first time in the literature...
July 20, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28983260/common-marmosets-a-potential-translational-animal-model-of-juvenile-depression
#10
Nicole Leite Galvão-Coelho, Ana Cecília de Menezes Galvão, Flávia Santos da Silva, Maria Bernardete Cordeiro de Sousa
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28968683/a-systems-level-analysis-of-drug-target-disease-associations-for-drug-repositioning
#11
Kayleigh D Rutherford, Gaston K Mazandu, Nicola J Mulder
Drug repositioning is the process of finding new therapeutic uses for existing, approved drugs-a process thathas value when considering the exorbitant costs of novel drug development. Several computational strategies exist as a way to predict these alternative applications. In this study, we used datasets on: (1) human biological drug targets and (2) disease-associated genes and, based on a direct functional interaction between them, searched for potential opportunities for drug repositioning. From the set of 1125 unique drug targets and their 88 490 interactions with disease-associated genes, 30 drug targets were analyzed and (3) discussed in detail for the purpose of this article...
August 17, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28893593/monoaminergic-neurotransmission-is-mediating-the-antidepressant-like-effects-of-passiflora-edulis-sims-fo-edulis
#12
Adriana S F S J Ayres, Wilton B Santos, Décio D Junqueira-Ayres, Geison M Costa, Freddy A Ramos, Leonardo Castellanos, Jovelina S F Alves, Laila Asth, Iris U de Medeiros, Silvana M Zucolotto, Elaine C Gavioli
The genus Passiflora is popularly used to treat anxiety. Recent studies showed antidepressant-like effects of two varieties of P. edulis (edulis and flavicarpa) in mice. However, the mechanisms of antidepressant actions are still unknown. Here, the effects of P. edulis fo. edulis aqueous extract (AE, 100-300mg/kg, po), and ethyl acetate (AcOEt, 25-50mg/kg, po), butanol (BuOH, 25-50mg/kg, po) and residual aqueous (25-100mg/kg, po) fractions were investigated in the mouse forced swimming test. In addition, the involvement of monoamines in the P...
November 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28890266/in-line-coupling-of-supported-liquid-membrane-extraction-to-capillary-electrophoresis-for-simultaneous-analysis-of-basic-and-acidic-drugs-in-urine
#13
Pavla Pantůčková, Pavel Kubáň
Simultaneous extraction of basic and acidic drugs across thin supported liquid membrane (SLM) and direct injection of the extracted drugs from SLM surface into capillary electrophoresis (CE) were demonstrated. A microextraction device compatible with injection system of commercial CE instrument was filled with 20μL of sample and 10μL of acceptor solution, which were interspaced by the SLM impregnated with 5μL of organic solvent. Extractions of three basic drugs (nortriptyline, haloperidol and loperamide) and two acidic drugs (ketoprofen and naproxen) were achieved at optimized conditions including 1-ethyl-2-nitrobenzene as SLM solvent, natural pH of sample solution, 2...
October 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28843554/comprehensive-study-of-buffer-systems-and-local-ph-effects-in-electromembrane-extraction
#14
Magnus Saed Restan, Henrik Jensen, Xiantao Shen, Chuixiu Huang, Ørjan Grøttem Martinsen, Pavel Kubáň, Astrid Gjelstad, Stig Pedersen-Bjergaard
Different phosphate-, acetate- and formate buffers in the pH range 2.0-6.8 were tested for electromembrane extraction (EME) in a 96-well system. The five basic drugs haloperidol, loperamide, methadone, nortriptyline, and pethidine were selected as model analytes. The EME performance was tested with respect to extraction recovery, extraction current and pH-stability. The analytes were extracted from 200 μL buffer, through a 100 μm thick supported liquid membrane (SLM) of 2-nitrophenyl octyl ether (NPOE) immobilized in the pores of filters in a 96-well plate, and into 100 μL buffer acceptor phase...
September 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28833834/estimates-of-effectiveness-and-reach-for-return-on-investment-modelling-of-smoking-cessation-interventions-using-data-from-england
#15
Robert West, Kathryn Coyle, Lesley Owen, Doug Coyle, Subhash Pokhrel
BACKGROUND AND AIMS: Estimating 'return on investment' (ROI) from smoking cessation interventions requires reach and effectiveness parameters for interventions for use in economic models such as the EQUIPT ROI tool (http://roi.equipt.eu). This paper describes the derivation of these parameter estimates for England that can be adapted to create ROI models for use by other countries. METHODS: Estimates were derived for interventions in terms of their reach and effectiveness in: (1) promoting quit attempts and (2) improving the success of quit attempts (abstinence for at least 12 months)...
August 18, 2017: Addiction
https://www.readbyqxmd.com/read/28817110/extractive-spectrophotometric-determination-of-nortriptyline-hydrochloride-using-sudan-ii-iv-and-black-b
#16
A S Amin, H M Saleh
A simple spectrophotometric methods has been developed for the determination of nortriptyline hydrochloride in pure and in pharmaceuticalformulations based on the formation of ion-pair complexes with sudun II (SII), sudan (IV) (SIV) and sudan black B (SBB). The selectivity of the method was improved through extraction with chloroform. The optimum conditions for complete extracted colour development were assessed. The absorbance measurements were made at 534, 596 and 649 nm for SII, SIV and SBB complexes, respectively...
August 17, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28800342/use-of-melatonin-versus-valproic-acid-in-prophylaxis-of-migraine-patients-a-double-blind-randomized-clinical-trial
#17
Mohsen Ebrahimi-Monfared, Mojtaba Sharafkhah, Ali Abdolrazaghnejad, Abolfazl Mohammadbeigi, Fardin Faraji
BACKGROUND: Melatonin is known to be effective in curing migraine. OBJECTIVE: This study aimed to investigate the therapeutic effect of melatonin versus sodium valproate in the prophylaxis of chronic migraine. METHODS: This randomized, double-blind, placebo-controlled clinical trial included patients with chronic migraine who were divided into three equal sized groups, and baseline therapy with nortriptyline (10-25 mg) and propranolol (20-40 mg) was used...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28775189/comparative-efficacy-and-acceptability-of-antidepressant-treatment-in-poststroke-depression-a-multiple-treatments-meta-analysis
#18
Yefei Sun, Yifan Liang, Yang Jiao, Jueying Lin, Huiling Qu, Junjie Xu, Chuansheng Zhao
OBJECTIVE: The aim of this study is to create a rank order of the comparative efficacy and acceptability (risk of all-cause discontinuation) of antidepressant treatment in poststroke depression (PSD) by integrating direct and indirect evidence. DESIGN: Multiple-treatments meta-analysis of randomised controlled trials. PARTICIPANTS: Patients with depression following stroke. INTERVENTIONS: 10 antidepressants and placebo in the acute treatment of PSD...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28769859/adverse-effects-of-antidepressants-for-chronic-pain-a-systematic-review-and-meta-analysis
#19
Carina Riediger, Tibor Schuster, Kristian Barlinn, Sarah Maier, Jürgen Weitz, Timo Siepmann
BACKGROUND: Antidepressants are widely used in the treatment of chronic pain. Applied doses are lower than those needed to unfold an antidepressive effect. While efficacy of antidepressants for chronic pain has been reported in large randomized-controlled trials (RCT), there is inconsistent data on adverse effects and tolerability. We aimed at synthesizing data from RCT to explore adverse effect profiles and tolerability of antidepressants for treatment of chronic pain. METHODS: Systematic literature research and meta-analyses were performed regarding side effects and safety of different antidepressants in the treatment of chronic pain according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28768370/efficacy-and-safety-of-nortriptyline-in-functional-dyspepsia-in-asians-a-randomized-double-blind-placebo-controlled-trial
#20
Uayporn Kaosombatwattana, Supot Pongprasobchai, Julajak Limsrivilai, Monthira Maneerattanaporn, Somchai Leelakusolvong, Tawesak Tanwandee
AIMS: Current treatments of functional dyspepsia (FD) are unsatisfied. Tricyclic antidepressants alter visceral hypersensitivity and brain-gut interaction. We assessed the efficacy and safety of nortriptyline in patients with FD. METHODS: Patients diagnosed functional dyspepsia according to Rome III criteria who failed to respond to proton pump inhibitor and prokinetic treatment were randomly assigned to either once daily 10-mg nortriptyline or placebo. The primary endpoint was the rate of responders defined as a > 50% reduction in dyspepsia symptom score(DSS) after 8 weeks of treatment...
August 2, 2017: Journal of Gastroenterology and Hepatology
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