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https://www.readbyqxmd.com/read/29333862/pharmacokinetic-determination-and-analysis-of-nortriptyline-based-on-gc-ms-coupled-with-hollow-fiber-drop-to-drop-solvent-microextraction-technique
#1
Pratik Kumar Jagtap, Kavita Tapadia
AIM: A simple, sensitive and robust technique of hollow-fiber drop-to-drop solvent microextraction coupled with GC-MS has been successfully developed for the detection of antidepressant drug nortriptyline in human blood and urine samples. The recoveries of the drug from the spiked samples are found to be well within the range and appropriate to support the method. RESULTS: The LOD for the drug was obtained to be 0.007, 0.009 and 0.021 μg ml-1 in deionized water, urine and blood samples of human subjects, respectively...
January 15, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29332813/fast-and-easy-extraction-of-antidepressants-from-whole-blood-using-ionic-liquids-as-extraction-solvent
#2
Marieke De Boeck, Lisa Dubrulle, Wim Dehaen, Jan Tytgat, Eva Cuypers
This study aims to prove that ionic liquids (ILs) can be used as extraction solvents in a liquid-liquid microextraction, coupled to LC-MS/MS, for the quantification of a large group of antidepressants in whole blood samples. The sample preparation procedure consisted of adding 1.0mL aqueous buffer pH 3.0 and 60µL of IL (1-butyl-3-methylimidazolium hexafluorophosphate) to 1.0mL whole blood. Subsequently, a 5-min rotary mixing step was performed followed by centrifugation. The lower IL phase was collected, diluted 1:10 in methanol and 10µL was injected into the LC-MS/MS...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29306690/differential-change-on-depressive-symptom-factors-with-antidepressant-medication-and-cognitive-behavior-therapy-for-major-depressive-disorder
#3
Boadie W Dunlop, Steven P Cole, Charles B Nemeroff, Helen S Mayberg, W Edward Craighead
BACKGROUND: Major depressive disorder (MDD) is a heterogeneous condition and individual patients are likely to be differentially responsive to specific treatments. In an exploratory factor analysis of three rating scales, the Genome-based Therapeutic Drugs for Depression (GENDEP) trial identified three factors that were differentially associated with outcome to nortriptyline and escitalopram. However, this factor analysis has neither been replicated or applied to a psychotherapy treatment...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29250815/current-and-emerging-pharmacotherapies-for-cessation-of-tobacco-smoking
#4
Nieves Gómez-Coronado, Adam J Walker, Michael Berk, Seetal Dodd
Tobacco use disorder is a chronic illness. With its high comorbidity rate, it is a major cause of years of life lost or years lived with disability; however, is also considered the most preventable cause of death in developed countries. Since the development of nicotine replacement therapy (NRT) in 1978, treatment options have continued to evolve and expand. Despite this, currently available treatments remain insufficient, with less than 25% of smokers remaining abstinent after one year after treatment. In this article, we review existing and emerging smoking cessation pharmacotherapies, affording a special emphasis on the most promising agents that are currently being investigated...
December 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29197244/systematic-assessment-of-different-solvents-for-the-extraction-of-drugs-of-abuse-and-pharmaceuticals-from-an-authentic-hair-pool
#5
Milena M Madry, Thomas Kraemer, Markus R Baumgartner
Hair analysis has been established as a prevalent tool for retrospective drug monitoring. In this study, different extraction solvents for the determination of drugs of abuse and pharmaceuticals in hair were evaluated for their efficiency. A pool of authentic hair from drug users was used for extraction experiments. Hair was pulverized and extracted in triplicate with seven different solvents in a one- or two-step extraction. Three one- (methanol, acetonitrile, and acetonitrile/water) and four two-step extractions (methanol two-fold, methanol and methanol/acetonitrile/formate buffer, methanol and methanol/formate buffer, and methanol and methanol/hydrochloric acid) were tested under accurately equal experimental conditions...
November 23, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29175411/mechanistic-pbpk-model-of-the-heart-accounting-for-inter-individual-variability-development-and-performance-verification
#6
Zofia Tylutki, Aleksander Mendyk, Sebastian Polak
Modern model-based approaches to cardiac safety and efficacy assessment require accurate drug concentration-effect relationship establishment. Thus, knowledge of the active concentration of drugs in heart tissue is desirable along with inter-subject variability influence estimation. To that end, we developed a mechanistic physiologically based pharmacokinetic (PBPK) model of the heart. The models were described with literature-derived parameters and written in R v.3.4.0. Five parameters were estimated. The model was fitted to amitriptyline and nortriptyline concentrations after an intravenous infusion of amitriptyline...
November 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29141255/is-venlafaxine-more-effective-than-escitalopram-and-nortriptyline-in-the-management-of-painful-symptoms-in-patients-with-major-depression
#7
Jan Jaracz, Karolina Gattner, Krystyna Jaracz, Krystyna Górna, Jerzy Moczko, Joanna Hauser
Background Conflicting data regarding the efficacy of antidepressants of different mechanism of action on unexplained painful physical symptoms (UPPS) in depression have been published so far. Objective The aim of this study was to compare the impact of escitalopram (ESC), nortriptyline (NOR), and venlafaxine (VEN) on UPPS in patients with major depression. Materials and methods Sixty patients, participants in the GENDEP study, with a diagnosis of depression according to the ICD-10 criteria were randomly assigned to treatment with ESC (10-30 mg, mean dose 15...
November 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29106712/investigation-of-ph-effect-on-cationic-solute-binding-to-keratin-and-partition-to-hair
#8
Lingyi Li, Senpei Yang, Tao Chen, Lujia Han, Guoping Lian
OBJECTIVE: In the process of hair treatment, various cationic actives contained in hair care products can be absorbed into hair fiber to modulate the physicochemical properties of hair such as color, strength, style and volume. There have been very limited studies on the binding and partition properties of hair care actives to hair. This study aimed to investigate the pH effects on cationic solute absorption into hair and binding to keratin. METHODS: The keratin binding and hair partition properties of three cationic solutes (theophylline, nortriptyline and amitriptyline) have been measured at different pH using fluorescence spectroscopy and equilibrium absorption experiment...
November 6, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29083873/direct-analysis-of-free-aqueous-and-organic-operational-solutions-as-a-tool-for-understanding-fundamental-principles-of-electromembrane-extraction
#9
Andrea Šlampová, Pavel Kubáň
Aqueous and organic phases in microelectromembrane extraction (μ-EME) were formed as adjacent plugs of free immiscible solutions in narrow-bore polymeric tubing, and each single phase was recovered and analyzed after μ-EME. A three-phase μ-EME setup was employed for investigation of time-dependent distribution of model basic drugs among aqueous and organic phases. Exact concentrations of nortriptyline and papaverine in donor solution, acceptor solution, and free liquid membrane (FLM) were determined by capillary electrophoresis with ultraviolet detection (CE-UV)...
November 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29075117/need-for-medication-to-complement-catecholamines-in-smoking-cessation-of-hardcore-smokers
#10
Atsuko Kawai, Masatake Kurita, Satoshi Nishino, Eishin Hirata, Tadahiro Sato, Yoshiro Okubo
Many smokers find it difficult to stop smoking without assistance. The antidepressants bupropion and nortriptyline can aid smoking cessation. The main aim of this study was to understand the pathophysiology of smoking cessation better based on biological backgrounds. We investigated the following biological markers for any alterations during smoking cessation in the absence of pharmacotherapy: the dopamine metabolite homovanillic acid (HVA), the noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and brain-derived neurotrophic factor (BDNF)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29065085/resolution-of-persistent-post-stapedotomy-vertigo-with-migraine-prophylactic-medication
#11
Omid Moshtaghi, Hossein Mahboubi, Yarah M Haidar, Ronald Sahyouni, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: To describe persistent post-stapedotomy vertigo (PSV) and its treatment using migraine prophylaxis. PATIENTS: A retrospective review of all patients with persistent PSV spanning 10 years at a tertiary academic hospital was performed. Patients who experienced persistent vertigo for a minimum of 3 months after surgery were included. Those with possible perilymph fistula, long prosthesis, and benign paroxysmal positional vertigo were excluded. INTERVENTIONS: All patients received instructions on migraine dietary and lifestyle changes and Vitamin B2 and magnesium...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29053849/a-network-meta-analysis-comparing-effects-of-various-antidepressant-classes-on-the-digit-symbol-substitution-test-dsst-as-a-measure-of-cognitive-dysfunction-in-patients-with-major-depressive-disorder
#12
Bernhard T Baune, Mélanie Brignone, Klaus Groes Larsen
Background: Major depressive disorder (MDD) is a common condition that often includes cognitive dysfunction. A systematic literature review of studies and a network meta-analysis (NMA) were carried out to assess the relative effect of antidepressants on cognitive dysfunction in MDD. Methods: MEDLINE ®, Embase ®, Cochrane, CDSR, PsychINFO ® databases, clinical trial registries, and relevant conference abstracts were searched for randomised controlled trials (RCTs) assessing the effects of antidepressants/placebo on cognition...
October 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29033248/use-of-oral-antidepressants-in-patients-with-chronic-pruritus-a-systematic-review
#13
Tessa A Kouwenhoven, Peter C M van de Kerkhof, Marijke Kamsteeg
BACKGROUND: Chronic pruritus is a common skin symptom with marked impact on quality of life. Adequate treatment can be challenging for clinicians, demanding the exploration of new treatment options such as oral antidepressants. OBJECTIVE: To evaluate the use of oral antidepressants in chronic pruritus by a systematic overview of the available relevant literature. METHODS: The PubMed, EMBASE, Cochrane, and Web of Science databases were searched...
October 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28991969/photosensitized-degradation-of-amitriptyline-and-its-active-metabolite-nortriptyline-in-aqueous-fulvic-acid-solution
#14
Yong Chen, Jianfeng Liang, Lu Liu, Xiye Lu, Jianwu Deng, Ivan P Pozdnyakov, Yuegang Zuo
Amitriptyline is a frequently prescribed tricyclic antidepressant. Although amitriptyline and its active metabolite, nortriptyline, have been widely detected in natural waters, their environmental fate due to photodegradation is poorly understood. Here we describe a study conducted to investigate the photodegradation of amitriptyline and its active metabolite under simulated sunlight. Neither amitriptyline nor nortriptyline underwent direct photodegradation, but rapid photosensitized degradation did occur in fulvic acid (FA) solutions...
September 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28985320/multiple-drug-toxicity-involving-novel-psychoactive-substances-3-fluorophenmetrazine-and-u-47700
#15
Kayla N Ellefsen, Elizabeth A Taylor, Paul Simmons, Vickie Willoughby, Brad J Hall
3-Fluorophenmetrazine (3-FPM) is a stimulant-like novel psychoactive substance (NPS) and fluorinated analog of phenmetrazine that has recently appeared on the recreational drug market, with limited published information. Likewise, the synthetic opioid U-47700 has gained popularity among recreational drug users and is frequently detected in postmortem casework. We present the case history, autopsy and toxicological findings of a fatality involving the designer drugs 3-FPM and U-47700 for the first time in the literature...
July 20, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28983260/common-marmosets-a-potential-translational-animal-model-of-juvenile-depression
#16
Nicole Leite Galvão-Coelho, Ana Cecília de Menezes Galvão, Flávia Santos da Silva, Maria Bernardete Cordeiro de Sousa
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28968683/a-systems-level-analysis-of-drug-target-disease-associations-for-drug-repositioning
#17
Kayleigh D Rutherford, Gaston K Mazandu, Nicola J Mulder
Drug repositioning is the process of finding new therapeutic uses for existing, approved drugs-a process thathas value when considering the exorbitant costs of novel drug development. Several computational strategies exist as a way to predict these alternative applications. In this study, we used datasets on: (1) human biological drug targets and (2) disease-associated genes and, based on a direct functional interaction between them, searched for potential opportunities for drug repositioning. From the set of 1125 unique drug targets and their 88 490 interactions with disease-associated genes, 30 drug targets were analyzed and (3) discussed in detail for the purpose of this article...
August 17, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28893593/monoaminergic-neurotransmission-is-mediating-the-antidepressant-like-effects-of-passiflora-edulis-sims-fo-edulis
#18
Adriana S F S J Ayres, Wilton B Santos, Décio D Junqueira-Ayres, Geison M Costa, Freddy A Ramos, Leonardo Castellanos, Jovelina S F Alves, Laila Asth, Iris U de Medeiros, Silvana M Zucolotto, Elaine C Gavioli
The genus Passiflora is popularly used to treat anxiety. Recent studies showed antidepressant-like effects of two varieties of P. edulis (edulis and flavicarpa) in mice. However, the mechanisms of antidepressant actions are still unknown. Here, the effects of P. edulis fo. edulis aqueous extract (AE, 100-300mg/kg, po), and ethyl acetate (AcOEt, 25-50mg/kg, po), butanol (BuOH, 25-50mg/kg, po) and residual aqueous (25-100mg/kg, po) fractions were investigated in the mouse forced swimming test. In addition, the involvement of monoamines in the P...
November 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28890266/in-line-coupling-of-supported-liquid-membrane-extraction-to-capillary-electrophoresis-for-simultaneous-analysis-of-basic-and-acidic-drugs-in-urine
#19
Pavla Pantůčková, Pavel Kubáň
Simultaneous extraction of basic and acidic drugs across thin supported liquid membrane (SLM) and direct injection of the extracted drugs from SLM surface into capillary electrophoresis (CE) were demonstrated. A microextraction device compatible with injection system of commercial CE instrument was filled with 20μL of sample and 10μL of acceptor solution, which were interspaced by the SLM impregnated with 5μL of organic solvent. Extractions of three basic drugs (nortriptyline, haloperidol and loperamide) and two acidic drugs (ketoprofen and naproxen) were achieved at optimized conditions including 1-ethyl-2-nitrobenzene as SLM solvent, natural pH of sample solution, 2...
October 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28843554/comprehensive-study-of-buffer-systems-and-local-ph-effects-in-electromembrane-extraction
#20
Magnus Saed Restan, Henrik Jensen, Xiantao Shen, Chuixiu Huang, Ørjan Grøttem Martinsen, Pavel Kubáň, Astrid Gjelstad, Stig Pedersen-Bjergaard
Different phosphate-, acetate- and formate buffers in the pH range 2.0-6.8 were tested for electromembrane extraction (EME) in a 96-well system. The five basic drugs haloperidol, loperamide, methadone, nortriptyline, and pethidine were selected as model analytes. The EME performance was tested with respect to extraction recovery, extraction current and pH-stability. The analytes were extracted from 200 μL buffer, through a 100 μm thick supported liquid membrane (SLM) of 2-nitrophenyl octyl ether (NPOE) immobilized in the pores of filters in a 96-well plate, and into 100 μL buffer acceptor phase...
September 1, 2017: Analytica Chimica Acta
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