Raed Obaid Saleh, Adnan Taan Alkhafaji, Jaafaru Sani Mohammed, Pooja Bansal, Harpreet Kaur, Irfan Ahmad, Ahmed Hjazi, Israa Hussein Mohammed, Mohammed Abed Jawad, Ahmed Hussein Zwamel
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long noncoding RNA (lncRNA) that is widely expressed in a variety of mammalian cell types. Altered expression levels of the lncRNA NEAT1 have been reported in liver-related disorders including cancer, fatty liver disease, liver fibrosis, viral hepatitis, and hepatic ischemia. lncRNA NEAT1 mostly acts as a competing endogenous RNA (ceRNA) to sponge various miRNAs (miRs) to regulate different functions. In regard to hepatic cancers, the elevated expression of NEAT1 has been reported to have a relation with the proliferation, migration, angiogenesis, apoptosis, as well as epithelial-mesenchymal transition (EMT) of cancer cells...
April 2024: Cell Biochemistry and Function