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https://www.readbyqxmd.com/read/28918602/population-pharmacokinetics-and-optimal-sampling-strategy-for-model-based-precision-dosing-of-melphalan-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#1
Kana Mizuno, Min Dong, Tsuyoshi Fukuda, Sharat Chandra, Parinda A Mehta, Scott McConnell, Elias J Anaissie, Alexander A Vinks
BACKGROUND: High-dose melphalan is an important component of conditioning regimens for patients undergoing hematopoietic stem cell transplantation. The current dosing strategy based on body surface area results in a high incidence of oral mucositis and gastrointestinal and liver toxicity. Pharmacokinetically guided dosing will individualize exposure and help minimize overexposure-related toxicity. OBJECTIVE: The purpose of this study was to develop a population pharmacokinetic model and optimal sampling strategy...
September 16, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28918601/effects-of-phoxim-induced-hepatotoxicity-on-sd-rats-and-the-protection-of-vitamin-e
#2
Jing Zhang, Wentao Song, Yuecheng Sun, Anshan Shan
Currently, public pay more attention to the adverse effect of organophosphate pesticides on human and animal health and on the environment in developing nations. Vitamin E may protect the hepatocyte and increase the function of liver. The study was to investigate the effects of phoxim-induced hepatotoxicity on Sprague Dawley (SD) rats and the protection of vitamin E. SD rats received by gavage 180 mg kg(-1) (per body weight) of phoxim, 200 mg kg(-1) (per body weight) of vitamin E, and phoxim + vitamin E...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918591/platform-model-describing-pharmacokinetic-properties-of-vc-mmae-antibody-drug-conjugates
#3
Matts Kågedal, Leonid Gibiansky, Jian Xu, Xin Wang, Divya Samineni, Shang-Chiung Chen, Dan Lu, Priya Agarwal, Bei Wang, Ola Saad, Neelima Koppada, Bernard M Fine, Jin Y Jin, Sandhya Girish, Chunze Li
Antibody-drug conjugates (ADCs) developed using the valine-citrulline-MMAE (vc-MMAE) platform, consist of a monoclonal antibody (mAb) covalently bound with a potent anti-mitotic toxin (MMAE) through a protease-labile vc linker. Recently, clinical data for a variety of vc-MMAE ADCs has become available. The goal of this analysis was to develop a platform model that simultaneously described antibody-conjugated MMAE (acMMAE) pharmacokinetic (PK) data from eight vc-MMAE ADCs, against different targets and tumor indications; and to assess differences and similarities of model parameters and model predictions, between different compounds...
September 16, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28918533/the-associations-between-dietary-patterns-and-bone-health-according-to-the-tgf-%C3%AE-1-t869%C3%A2-c-polymorphism-in-postmenopausal-iranian-women
#4
Sajjad Moradi, Leila Khorrami-Nezhad, Sima Ali-Akbar, Fatemeh Zare, Tanaz Alipour, Azadeh Dehghani Kari Bozorg, Mir Saeed Yekaninejad, Zhila Maghbooli, Khadijeh Mirzaei
BACKGROUND/OBJECTIVE: Recent studies have shown that dietary variants and genetic variants play a decisive role in the risk of developing osteoporosis. Therefore, the objective of the present study was to examine associations between dietary pattern and bone health, according to the TGF-β1 T869→C polymorphism, in postmenopausal Iranian women. MATERIALS AND METHODS: In this study, 264 postmenopausal women aged from 46 to 78 years were examined. Body composition was measured by a body composition analyzer and physical activity by the short-form physical activity questionnaire...
September 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28918476/effects-of-stocking-density-on-lipid-deposition-and-expression-of-lipid-related-genes-in-amur-sturgeon-acipenser-schrenckii
#5
Yuanyuan Ren, Haishen Wen, Yun Li, Jifang Li, Feng He, Meng Ni
To investigate the correlation between lipid deposition variation and stocking density in Amur sturgeon (Acipenser schrenckii) and the possible physiological mechanism, fish were conducted in different stocking densities (LSD 5.5 kg/m(3), MSD 8.0 kg/m(3), and HSD 11.0 kg/m(3)) for 70 days and then the growth index, lipid content, lipase activities, and the mRNA expressions of lipid-related genes were examined. Results showed that fish subjected to higher stocking density presented lower final body weights (FBW), specific growth ratio (SGR), and gonad adipose tissue index (GAI) (P < 0...
September 16, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28918362/there-are-no-no-responders-to-low-or-high-resistance-training-volumes-among-older-women
#6
Matheus de Siqueira Mendes Barbalho, Paulo Gentil, Mikel Izquierdo, James Fisher, James Steele, Rodolfo de Azevedo Raiol
OBJECTIVES: To assess the prevalence of non-responders to different tests and to compare the effects of different resistance training (RT) volumes on muscle strength, anthropometric and functional performance of older women. METHODS: Three hundred seventy six women performed 12weeks of RT with either low or high volume (LV, 71.29±5.77years and HV 69.73±5.88years, respectively). Both groups performed the same exercises, and all parameters were held constant except for the number of sets performed per week...
September 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28918168/adherence-to-a-mediterranean-diet-is-associated-with-lower-incidence-of-frailty-a-longitudinal-cohort-study
#7
Nicola Veronese, Brendon Stubbs, Marianna Noale, Marco Solmi, Renè Rizzoli, Alberto Vaona, Jacopo Demurtas, Gaetano Crepaldi, Stefania Maggi
BACKGROUND & AIMS: There is a paucity of data investigating the relationship between the Mediterranean diet and frailty, with no data among North American people. We aimed to investigate if adherence to a Mediterranean diet is associated with a lower incidence of frailty in a large cohort of North American people. METHODS: This study included subjects at higher risk or having knee osteoarthritis. Adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED) as proposed by Panagiotakos and classified into five categories...
September 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28918167/different-nutritional-assessment-tools-as-predictors-of-postoperative-complications-in-patients-undergoing-colorectal-cancer-resection
#8
Sílvia Fernandes Maurício, Jingjie Xiao, Carla M Prado, Maria Cristina Gonzalez, Maria Isabel Toulson Davisson Correia
BACKGROUND & AIMS: Malnutrition in patients with colorectal cancer contributes to increased postoperative complications. The aim of the study was to evaluate the prognostic value of several nutritional assessment parameters: body mass index versus percentage of weight loss grading system (BMI/%WL); Patient-Generated Subjective Global Assessment (PG-SGA); standardized phase angle (SPA) by BIA; muscle strength by handgrip strength; muscle mass by computerized tomography; and the combination of muscle mass and strength in patients undergoing resection surgery...
September 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28918138/characterizing-effects-of-feed-restriction-and-glucagon-like-peptide-2-administration-on-biomarkers-of-inflammation-and-intestinal-morphology
#9
S K Kvidera, E A Horst, M V Sanz Fernandez, M Abuajamieh, S Ganesan, P J Gorden, H B Green, K M Schoenberg, W E Trout, A F Keating, L H Baumgard
Inadequate feed consumption reduces intestinal barrier function in both ruminants and monogastrics. Objectives were to characterize how progressive feed restriction (FR) affects inflammation, metabolism, and intestinal morphology, and to investigate if glucagon-like peptide 2 (GLP2) administration influences the aforementioned responses. Twenty-eight Holstein cows (157 ± 9 d in milk) were enrolled in 2 experimental periods. Period 1 [5 d of ad libitum (AL) feed intake] served as baseline for period 2 (5 d), during which cows received 1 of 6 treatments: (1) 100% of AL feed intake (AL100; n = 3), (2) 80% of AL feed intake (n = 5), (3) 60% of AL feed intake (n = 5), (4) 40% of AL feed intake (AL40; n = 5), (5) 40% of AL feed intake + GLP2 administration (AL40G; 75 µg/kg of BW s...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917947/effect-of-meal-glycemic-load-and-caffeine-consumption-on-prolonged-monotonous-driving-performance
#10
Christopher Bragg, Ben Desbrow, Susan Hall, Christopher Irwin
OBJECTIVE: Monotonous driving involves low levels of stimulation and high levels of repetition and is essentially an exercise in sustained attention and vigilance. The aim of this study was to determine the effects of consuming a high or low glycemic load meal on prolonged monotonous driving performance. The effect of consuming caffeine with a high glycemic load meal was also examined. METHOD: Ten healthy, non-diabetic participants (7 males, age 51±7yrs, mean±SD) completed a repeated measures investigation involving 3 experimental trials...
September 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28917655/inactivation-of-tnf-lt-locus-alters-mouse-metabolic-response-to-concentrated-ambient-pm2-5
#11
Ziying Hu, Minjie Chen, Huifen Zhou, Anui Tharakan, Xiaoke Wang, Lianglin Qiu, Shuai Liang, Xiaobo Qin, Yuhao Zhang, Wanjun Wang, Yanyi Xu, Zhekang Ying
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2.5 exposure-induced pulmonary and subsequent systemic inflammation. Tumor necrosis factor alpha (TNFα), lymphotoxin α (LTα), and lymphotoxin β (LTβ) are three homologous pro-inflammatory cytokines, each with both unique and redundant activities in inflammation. Their role in PM2.5 exposure-induced inflammation and adverse cardiometabolic effects has to be determined...
September 13, 2017: Toxicology
https://www.readbyqxmd.com/read/28917503/food-reluctance-of-preschool-children-attending-daycare-centers-is-associated-with-a-lower-body-mass-index
#12
Véronique Surette, Stéphanie Ward, Pascale Morin, Hassan Vatanparast, Mathieu Bélanger
BACKGROUND: Food reluctance can present as fussiness, picky eating, slowness in eating, and high satiety responsiveness. It can be associated with inadequate weight gain during early childhood. Although a majority of preschoolers attend daycare centers, associations between their eating behaviors at daycare and their body composition have not been studied. OBJECTIVE: Our aim was to develop an estimate of food reluctance and to assess the relationship between food reluctance at daycare and body mass index (BMI) and waist circumference of preschoolers...
September 14, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28917449/highly-potent-antiobesity-effect-of-a-short-length-peptide-yy-analog-in-mice
#13
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yoko Kanematsu-Yamaki, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Yoko Noguchi, Tomoko Asakawa, Hideki Hirabayashi, Nobuyuki Amano, Shiro Takekawa, Tetsuya Ohtaki, Taiji Asami
Continuous administration of a 14-amino acid peptide YY (PYY) analog, Ac-[d-Pro(24),Pya(4)(26),Cha(27,36),Aib(28,31),Lys(30)]PYY(23-36) (4), which has a high binding affinity and agonist activity for the neuropeptide Y2 receptor (Y2R), has previously shown an antiobesity effect in a 2-week diet-induced obesity (DIO) study in mice. However, there remained a possibility to obtain more potent analogs by further improving its pharmacokinetic profile. A combination of the N-terminal 4-imidazolecarbonyl moiety and three amino acid substitutions, trans-4-hydroxy-d-proline (d-Hyp)(24), isovaline (Iva)(25), and γ-methylleucine (γMeLeu)(28), not only improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice...
September 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28917236/dietary-intake-of-heme-iron-and-body-iron-status-are-associated-with-the-risk-of-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#14
Lu Zhao, Jia Lian, Jishun Tian, Ye Shen, Zhiguang Ping, Xuexian Fang, Junxia Min, Fudi Wang
BACKGROUND AND OBJECTIVES: Some potential role of iron overload in the development of diabetes mellitus have been suggested. Our study aimed to systematically assess the association between the risk of gestational diabetes mellitus (GDM) and iron intakes/body iron status. METHODS AND STUDY DESIGN: PubMed and Web of Science were searched for relevant articles. Relative risks (RR) of GDM in relation to dietary iron intakes and body iron stores were pooled with the random-effects model...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917234/association-between-complement-component-c3-and-body-composition-a-possible-obesity-inflammatory-biomarker-for-insulin-resistance
#15
Hayder A Al-Domi, Reem M Al Haj Ahmad
BACKGROUND AND OBJECTIVES: The C3 complement component (C3) is increasingly recognized as a cardiometabolic risk factor. We aimed to examine the role of C3 in insulin resistance (IR) and its association with adiposity. METHODS AND STUDY DESIGN: Sixty-seven obese (18-35 years) participants were matched with normal weight participants from the University of Jordan. BMI, waist-hip ratio (WHpR), and waist-height ratio (WHtR) were calculated. Body percent fat mass (%FM) was determined using the bioelectrical impedance analysis...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917231/portion-controlled-ready-to-eat-meal-replacement-is-associated-with-short-term-weight-loss-a-randomised-controlled-trial
#16
Rebecca Kuriyan, Deepa P Lokesh, Ninoshka D'Souza, Divya J Priscilla, Chandni Halcyon Peris, Sumithra Selvam, Anura V Kurpad
BACKGROUND AND OBJECTIVES: Strategies to prevent and treat overweight/obesity are urgently needed. This study assessed the effect of a short-term intake of ready-to-eat cereal on body weight and waist circumference of overweight/obese individuals in comparison to a control group. METHODS AND STUDY DESIGN: A randomized, controlled 2-arm trial was carried out on 101 overweight/obese (Body Mass Index - 29.2±2.4 kg/m2) females aged 18 to 44 years, at St. John's Medical College Hospital...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917230/energy-restriction-combined-with-green-coffee-bean-extract-affects-serum-adipocytokines-and-the-body-composition-in-obese-women
#17
Fatemeh Haidari, Mehnoosh Samadi, Majid Mohammadshahi, Mohammad Taha Jalali, Kambiz Ahmadi Engali
BACKGROUND AND OBJECTIVES: Obesity has become a public health problem and is a cause of some preventable illnesses. Among several methods for treating obesity, the use of food supplements is highly common. A commonly used food supplement is green coffee bean extract. The objective of this study was to evaluate the efficacy of green coffee bean extract combined with an energy-restricted diet on the body composition and serum adipocytokines in obese women. METHODS AND STUDY DESIGN: In this randomised clinical trial, 64 obese women aged 20-45 years were selected and divided into two groups: an intervention group (receiving 400 mg green coffee bean extract for 8 weeks) and control group (receiving placebo)...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917228/parenteral-nutrition-combined-with-enteral-feeding-improves-the-outcome-of-cancer-patients
#18
Pei-Chun Chao, Cheau-Feng Lin, Hui-Ju Chuang
BACKGROUND AND OBJECTIVES: This study investigated whether total parenteral nutrition combined with enteral nutrition is associated with improved biochemical and clinical outcomes in cancer patients with gastrointestinal dysfunction. METHODS AND STUDY DESIGN: From January to December 2014, the clinical data of 68 patients in a cancer ward were retrospectively collected, and these patients were classified into two groups according to nutrition delivery, through parenteral nutrition, combined with enteral nutrition more (group A) or less (group B) than 250 kcal/day...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917225/appropriate-nutritional-management-in-patients-with-impaired-mastication-and-those-with-mild-dysphagia-a-multicenter-study-of-the-usefulness-of-novel-foods-processed-and-softened-by-enzymes
#19
Takashi Higashiguchi, Akihiro Ito, Hirofumi Nishiyama, Takashi Shigematsu, Atsuko Ishikawa, Hiroyuki Kato, Shohei Iijima, Nobuyuki Kikuchi
BACKGROUND AND OBJECTIVES: Our aim was to investigate the safety of iEAT (a food that is softened by heat and enzyme homogeneous permeation) and iEAT-affected nutrition parameters, e.g., nutrition intake (calculated from the consumption rate in patients with impaired mastication and those with mild dysphagia). METHODS AND STUDY DESIGN: A multicenter, randomized, cross-over study of iEAT was conducted in 50 patients (mean age 77.0±11.0 years) with dysphagia due to Occasional aspiration (4 points on the Dysphagia Severity Scale [DSS]) or Oral problems (5 points) randomly assigned to the study diet (iEAT) or its opposite (the modified traditional [control] diet) for 1 week and then switched for 1 week to the opposing diet...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917223/validity-of-the-malnutrition-universal-screening-tool-must-in-australian-hospitalized-acutely-unwell-elderly-patients
#20
Yogesh Sharma, Campbell Thompson, Billingsley Kaambwa, Rashmi Shahi, Michelle Miller
BACKGROUND AND OBJECTIVES: This study validated the Malnutrition Universal Screening Tool (MUST) for nutritional screening in acutely unwell elderly patients against a reference assessment tool - Patient-Generated Subjective Global Assessment (PG-SGA). METHODS AND STUDY DESIGN: One hundred and thirty two acutely admitted general medical patients contributed data for this study. In addition to performance of MUST and PG-SGA the following nutritional parameters were measured: weight loss >5% in previous 3-6 months, handgrip strength, triceps skinfold thickness, Mid-arm circumference, Mid-arm muscle circumference (MAMC)...
2017: Asia Pacific Journal of Clinical Nutrition
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