Francesco Siracusa, Nicola Schaltenberg, Yogesh Kumar, Till R Lesker, Babett Steglich, Timur Liwinski, Filippo Cortesi, Laura Frommann, Björn-Phillip Diercks, Friedericke Bönisch, Alexander W Fischer, Pasquale Scognamiglio, Mira J Pauly, Christian Casar, Yotam Cohen, Penelope Pelczar, Theodora Agalioti, Flemming Delfs, Anna Worthmann, Ramez Wahib, Bettina Jagemann, Hans-Willi Mittrücker, Oliver Kretz, Andreas H Guse, Jakob R Izbicki, Kara G Lassen, Till Strowig, Michaela Schweizer, Eduardo J Villablanca, Eran Elinav, Samuel Huber, Joerg Heeren, Nicola Gagliani
Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods of time, but the health consequences of this short-term consumption of energy-dense nutrients are unclear. Here, we show that short-term reiterative switching to 'feast diets', mimicking our social eating behavior, breaches the potential buffering effect of the intestinal microbiota and reorganizes the immunological architecture of mucosa-associated lymphoid tissues...
September 2023: Nature Immunology