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https://www.readbyqxmd.com/read/28718067/theoretical-and-experimental-in-vivo-study-of-antioxidant-activity-of-crocin-in-order-to-propose-novel-derivatives-with-higher-antioxidant-activity-and-their-delivery-via-nanotubes-and-nanocones
#1
Houshang Najafi, Zeynab Mohamadi Yarijani, Meysam Najafi
In this study, the antioxidant activity of crocin via experimental and theoretical methods was investigated. In order to induce oxidative stress, 30-min renal ischemia and 24-h reperfusion were used in male Wistar rats. Oxidative stress was assessed by measuring tissue malondialdehyde (MDA) and ferric reducing/antioxidant power (FRAP). The results showed that following ischemia/reperfusion, the level of MDA was increased and FRAP decreased. Both of these changes were alleviated by crocin administration. The bond dissociation enthalpy and ionization potential values as enthalpies of mechanism of antioxidant activity of crocin were calculated by density functional theory method...
July 17, 2017: Inflammation
https://www.readbyqxmd.com/read/28716911/activation-and-synchronization-of-the-oscillatory-morphodynamics-in-multicellular-monolayer
#2
Shao-Zhen Lin, Bo Li, Ganhui Lan, Xi-Qiao Feng
Oscillatory morphodynamics provides necessary mechanical cues for many multicellular processes. Owing to their collective nature, these processes require robustly coordinated dynamics of individual cells, which are often separated too distantly to communicate with each other through biomaterial transportation. Although it is known that the mechanical balance generally plays a significant role in the systems' morphologies, it remains elusive whether and how the mechanical components may contribute to the systems' collective morphodynamics...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28715171/limitations-of-structural-superlubricity-chemical-bonds-versus-contact-size
#3
Dirk Dietzel, Ján Brndiar, Ivan Štich, André Schirmeisen
Structural superlubricity describes the state of virtually frictionless sliding if two atomically flat interfaces are incommensurate, that is, they share no common periodicity. Despite the exciting prospects of this low friction phenomenon, there are physical limitations to the existence of this state. Theory predicts that the contact size is one fundamental limit, where the critical size threshold mainly depends on the interplay between lateral contact compliance and interface interaction energies. Here we provide experimental evidence for this size threshold by measuring the sliding friction force of differently sized antimony particles on MoS2...
July 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28714708/ethnic-identity-in-context-of-ethnic-discrimination-when-does-gender-and-other-group-orientation-increase-risk-for-depressive-symptoms-for-immigrant-origin-young-adults
#4
M Alexander Thibeault, Gabriela L Stein, Rosemery O Nelson-Gray
OBJECTIVES: Ethnic discrimination increases risk for depressive symptoms, but less is known about factors that influence the impact of this cultural challenge on psychological adjustment for immigrant-origin college students. Sociocultural identity development is especially relevant during emerging adulthood. Studies examining exacerbating or buffering impacts of ethnic identity have yielded mixed results. The current study examines conditions under which one aspect of ethnic identity, affirmation/belonging, moderates the impact of perceived ethnic discrimination stress on depressive symptoms...
July 17, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28714388/the-prospective-role-of-micrornas-in-depression
#5
Zhiying Hu, Yuting Jiang, Xue Huo, Yang Yang, Henry Davies, Benson O A Botchway, Marong Fang
Depression is a debilitating disease that is affecting a growing number of patients both physically and mentally. In addition to the mood changes, depression causes cognitive impairment, including learning and memory dysfunction. Although depression studies have been going on for decades, the underlying mechanism still remains unclear. MicroRNAs (miRNAs), a type of small non-coding RNAs, predominantly control the expression of their target mRNAs to exert their functions. Some evidence has revealed the importance of miRNAs in the mechanism of depression though the studies are still in their infancy...
July 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28713306/parenting-with-ptsd-a-review-of-research-on-the-influence-of-ptsd-on-parent-child-functioning-in-military-and-veteran-families
#6
REVIEW
Suzannah K Creech, Gabriela Misca
Posttraumatic stress disorder (PTSD) is strongly associated with exposure to war related trauma in military and veteran populations. In growing recognition that PTSD may influence and be influenced by social support and family systems, research has begun to explore the effects that war related trauma and the ensuing PTSD may have on varied aspects of close relationship and family functioning. Far less research, however, has examined the influence of war-related PTSD on parent-child functioning in this population...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28711797/symptom-severity-and-disability-in-psychiatric-disorders-the-u-s-collaborative-psychiatric-epidemiology-survey
#7
R García-Velázquez, M Jokela, T H Rosenström
BACKGROUND: While most psychiatric diagnoses are based on simple counts of symptoms, some symptoms may be sign of a more severe mental syndrome than others. This calls for validated estimates of the relative severity specific symptoms imply within a disorder. We focused on four diagnostic disorders: Manic Episode (ME), Major Depressive Episode (MDE), Post-traumatic Stress Disorder (PTSD) and Generalized Anxiety Disorder (GAD). Symptom-specific severity parameters were estimated, and validated by examining their association with levels of self-reported disability in daily activities over and above the number of symptoms...
July 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28709975/buckling-analysis-of-orthotropic-protein-microtubules-under-axial-and-radial-compression-based-on-couple-stress-theory
#8
Yaghoub Tadi Beni, M Karimi Zeverdejani, F Mehralian
Protein microtubules (MTs) are one of the important intercellular components and have a vital role in the stability and strength of the cells. Due to applied external loads, protein microtubules may be involved buckling phenomenon. Due to impact of protein microtubules in cell reactions, it is important to determine their critical buckling load. Considering nature of protein microtubules, various parameters are effective on microtubules buckling. The small size of microtubules and also lack of uniformity of MTs properties in different directions caused the necessity of accuracy in the analysis of these bio-structure...
July 11, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28704274/maternal-separation-induces-long-term-effects-on-monoamines-and-brain-derived-neurotrophic-factor-levels-on-the-frontal-cortex-amygdala-and-hippocampus-differential-effects-after-a-stress-challenge
#9
Soledad Récamier-Carballo, Erika Estrada-Camarena, Carolina López-Rubalcava
The maternal separation (MS) paradigm is a well-known animal model that resembles the stress of early adverse life experiences and produces structural and functional abnormalities when animals are adults. The present study analyzed the effect of MS, in adult mice, on brain-derived neurotrophic factor (BDNF), serotonin (5-HT), and dopamine (DA) levels, and the turnover rate in the hippocampus, frontal cortex, and amygdala, and brain regions that are associated with emotion. Also, the effects of MS in depression-like responses in adult mice were studied...
July 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28702660/poynting-and-reverse-poynting-effects-in-soft-materials
#10
C O Horgan, J G Murphy
In 1909, J. H. Poynting conducted a series of experiments on metal wires and found that loaded wires lengthen when twisted. Thus to maintain a constant length in such experiments, a compressive axial force would need to be applied at the ends of the specimen. This is the classical (positive) Poynting effect. Another example of such an effect arises when a soft material specimen is being axially sheared or rotated between two platens. The necessity to apply a normal force in order to maintain the relative distance between the platens is also often referred to as a Poynting-type effect...
July 12, 2017: Soft Matter
https://www.readbyqxmd.com/read/28700701/development-and-validation-of-the-maugeri-sleep-quality-and-distress-inventory-masqudi-17
#11
Elisa Morrone, Cinzia Sguazzin, Giorgio Bertolotti, Andrea Giordano, Alberto Braghiroli, Gian Luigi Balestroni, Raffaele Manni, Luigi Ferini Strambi, Vincenza Castronovo, Marco Zucconi, Fabrizio De Carli, Eleonora Pinna, Marcella Ottonello, Ines Giorgi, Michele Terzaghi, Sara Marelli, Francesco Fanfulla
OBJECTIVES: The aim of this study was to develop and validate a questionnaire designed to measure the impact of sleep impairment on emotional distress in patients with various sleep disorders. METHODS: Five experts created an item data-bank pertaining to sleep-related psychological symptoms and somatic perceptions. Fifty patients in two focus groups examined each item for: a) word clarity (indicating any ambiguity of interpretation) and b) appropriateness for the target population...
2017: PloS One
https://www.readbyqxmd.com/read/28700241/direct-observation-of-pac-man-coarsening
#12
Xiaoxiang Yu, Ahmet Gulec, Aram Yoon, Jian-Min Zuo, Peter W Voorhees, Laurence D Marks
We report direct observation of a 'Pac-Man' like coarsening mechanism of a self-supporting thin film of nickel oxide. The ultra-thin film has an intrinsic morphological instability due to surface stress leading to the development of local thicker regions at step edges. Density functional theory calculations and continuum modelling of the elastic instability support the model for the process.
July 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/28699940/association-of-stress-biomarkers-with-30-day-unplanned-readmission-and-death
#13
Carole Aubert, Antoine Folly, Mancinetti Marco, Daniel Hayoz, Jacques Donze
BACKGROUND: The theory that posthospitalization stress might increase the risk of postdischarge complications has never been investigated. OBJECTIVE: To assess whether serum levels of stress biomarkers at discharge are associated with readmission and death after an acute-care hospitalization. DESIGN: We prospectively included 346 patients aged ≥50 years admitted to the department of general internal medicine at a large community hospital between April 8, 2013 and September 23, 2013...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28698112/slow-aging-in-mammals-lessons-from-african-mole-rats-and-bats
#14
REVIEW
Philip Dammann
Traditionally, the main mammalian models used in aging research have been mice and rats, i.e. short-lived species that obviously lack effective maintenance mechanisms to keep their soma in a functional state for prolonged periods of time. It is doubtful that life-extending mechanisms identified only in such short-lived species adequately reflect the diversity of longevity pathways that have naturally evolved in mammals, or that they have much relevance for long-lived species such as humans. Therefore, some complementary, long-lived mammalian models have been introduced to aging research in the past 15-20 years, particularly naked mole-rats (and to a lesser extent also other mole-rats) and bats...
July 8, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28696435/a-direct-test-of-the-diathesis-stress-model-for-depression
#15
L Colodro-Conde, B Couvy-Duchesne, G Zhu, W L Coventry, E M Byrne, S Gordon, M J Wright, G W Montgomery, P A F Madden, S Ripke, L J Eaves, A C Heath, N R Wray, S E Medland, N G Martin
The diathesis-stress theory for depression states that the effects of stress on the depression risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects on the liability scale. We used polygenic risk scores for major depressive disorder (MDD) calculated from the results of the most recent analysis from the Psychiatric Genomics Consortium as a direct measure of the vulnerability for depression in a sample of 5221 individuals from 3083 families. In the same we also had measures of stressful life events and social support and a depression symptom score, as well as DSM-IV MDD diagnoses for most individuals...
July 11, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28695528/never-forget-negative-emotional-valence-enhances-recapitulation
#16
Holly J Bowen, Sarah M Kark, Elizabeth A Kensinger
A hallmark feature of episodic memory is that of "mental time travel," whereby an individual feels they have returned to a prior moment in time. Cognitive and behavioral neuroscience methods have revealed a neurobiological counterpart: Successful retrieval often is associated with reactivation of a prior brain state. We review the emerging literature on memory reactivation and recapitulation, and we describe evidence for the effects of emotion on these processes. Based on this review, we propose a new model: Negative Emotional Valence Enhances Recapitulation (NEVER)...
July 10, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28695343/posterior-colporrhaphy-does-not-affect-the-urethral-closure-mechanism
#17
Yasmine Khayyami, Gunnar Lose, Niels Klarskov
INTRODUCTION AND HYPOTHESIS: Studies have suggested that a posterior vaginal wall prolapse might compress the urethra and mask stress urinary incontinence (SUI), much like an anterior vaginal wall prolapse. A recent study with urethral pressure reflectometry (UPR) has shown that the urethral closure mechanism deteriorates after anterior colporrhaphy; this could explain the occurrence of postoperative de novo SUI. We hypothesized that urethral pressure would also decrease after posterior colporrhaphy...
July 10, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28694859/interplay-between-prolactin-and-pathogenesis-of-psoriasis-vulgaris
#18
Delia Botezatu, Mihaela Tovaru, Simona-Roxana Georgescu, Oana-Diana Leahu, Calin Giurcaneanu, Antoanela Curici
INTRODUCTION: The polypeptide hormone prolactin (PRL) represents the pituitary modulator of lactation and reproduction. Currently, we discuss the wide range of PRL actions "beyond the mammary horizon". Multiple studies had showed the role of PRL as a cytokine, with comparable structural motifs, similar receptor structures and signal transduction pathways. Almost two decades ago it was fi rst hypothesized that PRL acts as a neuroendocrine modulator of both skin epithelial growth and the skin immune system...
September 2016: Mædica
https://www.readbyqxmd.com/read/28694237/phase-transitions-during-compression-and-decompression-of-clots-from-platelet-poor-plasma-platelet-rich-plasma-and-whole-blood
#19
Xiaojun Liang, Irina Chernysh, Prashant K Purohit
Blood clots are required to stem bleeding and are subject to a variety of stresses, but they can also block blood vessels and cause heart attacks and ischemic strokes. We measured the compressive response of human platelet-poor plasma (PPP) clots, platelet-rich plasma (PRP) clots and whole blood clots and correlated these measurements with confocal and scanning electron microscopy to track changes in clot structure. Stress-strain curves revealed four characteristic regions, for compression-decompression: 1) linear elastic region; 2) upper plateau or softening region; 3) non-linear elastic region or re-stretching of the network; 4) lower plateau in which dissociation of some newly made connections occurs...
July 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28692948/parenting-children-with-down-syndrome-an-analysis-of-parenting-styles-parenting-dimensions-and-parental-stress
#20
B Allyson Phillips, Frances Conners, Mary Elizabeth Curtner-Smith
BACKGROUND: Effective parenting is vital for a child's development. Although much work has been conducted on parenting typically developing children, little work has examined parenting children with Down syndrome. AIMS: The purpose of the current study was to compare the parenting styles and dimensions in mothers of children with DS and mothers of TD children. METHODS AND PROCEDURES: Thirty-five mothers of children with DS and 47 mothers of TD children completed questionnaires about parenting, parental stress, child behavior problems, and child executive function...
July 7, 2017: Research in Developmental Disabilities
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