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https://www.readbyqxmd.com/read/28319893/role-of-macrophages-in-age-related-oxidative-stress-and-lipofuscin-accumulation-in-mice
#1
Carmen Vida, Irene Martínez de Toda, Julia Cruces, Antonio Garrido, Mónica Gonzalez-Sanchez, Mónica De la Fuente
The age-related changes in the immune functions (immunosenescence) may be mediated by an increase of oxidative stress and damage affecting leukocytes. Although the "oxidation-inflammation" theory of aging proposes that phagocytes are the main immune cells contributing to "oxi-inflamm-aging", this idea has not been corroborated. The aim of this work was to characterize the age-related changes in several parameters of oxidative stress and immune function, as well as in lipofuscin accumulation ("a hallmark of aging"), in both total peritoneal leukocyte population and isolated peritoneal macrophages...
March 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28318307/stress-socializing-and-other-motivations-for-smoking-among-the-lesbian-gay-bisexual-transgender-and-queer-community-in-new-york-city
#2
Deanna P Jannat-Khah, LeConté J Dill, Simone A Reynolds, Michael A Joseph
PURPOSE: This study contributes to the emerging literature on lesbian, gay, bisexual, transgendered, and queer (LGBTQ) health disparities and tobacco use by examining the motivations for smoking among the New York City (NYC) LGBTQ population. APPROACH: We used grounded theory and blended methods from 3 grounded theorists-Strauss, Corbin, and Charmaz-for data collection, coding, and analysis. SETTING: NYC has extensive legislation to prevent smoking; however, the current smoking prevalence of homosexuals is double that of heterosexuals...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28317484/redox-systems-antioxidants-and-sarcopenia
#3
Bertrand Fougère, Gabor Abellan van Kan, Bruno Vellas, Matteo Cesari
According to the free-radical theory of aging, oxidative stress is a key contributor to the onset of age-related conditions by inducing structural and functional alterations in several cellular components. Although innate defenses exist for limiting the occurrence of such detrimental effects, their ability to counteract the continuous and large production of reactive oxygen species becomes increasingly inefficient with aging. In this context, interventions aimed at preserving the homeostatic balance between oxidant production and antioxidant protection may be beneficial on the pathophysiological modifications and clinical manifestations featuring the aging process...
March 17, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28315113/-i-d-been-like-freaking-out-the-whole-night-exploring-emotion-regulation-based-on-junior-doctors-narratives
#4
Robert M Lundin, Kiran Bashir, Alison Bullock, Camille E Kostov, Karen L Mattick, Charlotte E Rees, Lynn V Monrouxe
The importance of emotions within medical practice is well documented. Research suggests that how clinicians deal with negative emotions can affect clinical decision-making, health service delivery, clinician well-being, attentiveness to patient care and patient satisfaction. Previous research has identified the transition from student to junior doctor (intern) as a particularly challenging time. While many studies have highlighted the presence of emotions during this transition, how junior doctors manage emotions has rarely been considered...
March 17, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28314705/adolescents-daily-worry-morning-cortisol-and-health-symptoms
#5
Reout Arbel, Lauren Spies Shapiro, Adela C Timmons, Ilana Kellerman Moss, Gayla Margolin
PURPOSE: To assess short-term effects of daily worries on hypothalamic-pituitary-adrenal axis activity and later implications for adolescents' health symptoms. We hypothesized that heightened worry would be associated with stronger next-morning cortisol awakening response (CAR) to prepare the body for the demands of the upcoming day. Guided by biological adaptation to stress theories, we also hypothesized that dysregulated CAR would heighten associations between worries and later health symptoms, while also testing direct associations between worries and dysregulated CAR and health...
March 14, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28314502/nutrient-sensing-and-the-oxidative-stress-response
#6
REVIEW
Hanzhi Luo, Hou-Hsien Chiang, Makensie Louw, Albert Susanto, Danica Chen
The simplicity and effectiveness of calorie restriction (CR) in lifespan and healthspan extension have fascinated generations searching for the Fountain of Youth. CR reduces levels of oxidative stress and damage, which have been postulated in the free radical theory of aging as a major cause of aging and diseases of aging. This reduction has long been viewed as a result of passive slowing of metabolism. Recent advances in nutrient sensing have provided molecular insights into the oxidative stress response and suggest that CR triggers an active defense program involving a cascade of molecular regulators to reduce oxidative stress...
March 14, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28298095/membrane-stress-profiles-from-self-consistent-field-theory
#7
Christina L Ting, Marcus Müller
Using self-consistent field theory (SCFT), we develop an accurate, local expression for the stress profiles in membranes and soft matter interfaces, in general. The bond stresses are expressed in terms of pre-computed chain propagators, which are used to describe the statistical weight of the molecules and therefore require minimal additional calculations. In addition, we overcome the resolution limit of the molecular bond length by including the Irving and Kirkwood bond assignment and recover a constant normal stress profile across an interface...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28297960/localization-and-instability-in-sheared-granular-materials-role-of-friction-and-vibration
#8
Konik R Kothari, Ahmed E Elbanna
Shear banding and stick-slip instabilities have been long observed in sheared granular materials. Yet, their microscopic underpinnings, interdependencies, and variability under different loading conditions have not been fully explored. Here we use a nonequilibrium thermodynamics model, the Shear Transformation Zone theory, to investigate the dynamics of strain localization and its connection to stability of sliding in sheared, dry, granular materials. We consider frictional and frictionless grains as well as the presence and absence of acoustic vibrations...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28297874/hydrodynamics-wall-slip-and-normal-stress-differences-in-rarefied-granular-poiseuille-flow
#9
Ronak Gupta, Meheboob Alam
Hydrodynamic fields, macroscopic boundary conditions, and non-Newtonian rheology of the acceleration-driven Poiseuille flow of a dilute granular gas are probed using "direct simulation Monte Carlo" method for a range of Knudsen numbers (Kn, the ratio between the mean free path and the macroscopic length), spanning the rarefied regime of slip and transitional flows. It is shown that the "dissipation-induced clustering" (for 1-e_{n}>0, where e_{n} is the restitution coefficient), leading to inhomogeneous density profiles along the transverse direction, competes with "rarefaction-induced declustering" (for Kn>0) phenomenon, leaving seemingly "anomalous" footprints on several hydrodynamic and rheological quantities; one example is the well-known rarefaction-induced temperature bimodality, which could also result from inelastic dissipation that dominates in the continuum limit (Kn→0) as found recently [Alam et al...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28294312/the-mediating-role-of-cultural-coping-behaviours-on-the-relationships-between-academic-stress-and-positive-psychosocial-well-being-outcomes
#10
Ben C H Kuo, Kendall M Soucie, Siqi Huang, Refa Laith
While culture's effect on the coping process has long been acknowledged in the stress-coping literature conceptually, empirical evidence and attempts to discern the specific relationship between culture and coping remain very scarce. Against this backdrop, the present study applied the Cultural Transactional Theory (Chun, Moos, & Cronkite, 2006) to examine the mediating role of cultural coping behaviours (Collective, Engagement and Avoidance Coping) on the relationship between academic stress (AS) and two positive psychosocial well-being outcome measures: Collective Self-esteem (CSE) and Subjective Well-being (SWB)...
March 10, 2017: International Journal of Psychology: Journal International de Psychologie
https://www.readbyqxmd.com/read/28291687/structural-biomechanics-of-the-craniomaxillofacial-skeleton-under-maximal-masticatory-loading-inferences-and-critical-analysis-based-on-a-validated-computational-model
#11
Amir R Pakdel, Cari M Whyne, Jeffrey A Fialkov
BACKGROUND: The trend towards optimizing stabilization of the craniomaxillofacial skeleton (CMFS) with the minimum amount of fixation required to achieve union, and away from maximizing rigidity, requires a quantitative understanding of craniomaxillofacial biomechanics. This study uses computational modeling to quantify the structural biomechanics of the CMFS under maximal physiologic masticatory loading. METHODS: Using an experimentally validated subject-specific finite element (FE) model of the CMFS, the patterns of stress and strain distribution as a result of physiological masticatory loading were calculated...
February 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28291277/diagnostiska-fel-och-misstag-%C3%A3-r-vanliga-och-sv%C3%A3-ra-att-m%C3%A3-ta
#12
Anders von Heijne
Diagnostic errors are prevalent and hard to measure Diagnostic errors are prevalent in all aspects of healthcare and a common cause of adverse events. They are often the result of multifactorial events, where there is a complex interplay between cognitive factors, system factors and lack of adequate knowledge. The generic, iterative diagnostic process, with abductive, deductive and inductive components supported by tests and the physical exam, leads to a correct diagnosis for the great majority of patients, but can be derailed by suboptimal thinking, lack of adequate information and external factors such as stress and work overload...
March 13, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28290742/patients-beliefs-about-the-causes-of-myomas-a-pilot-study-from-a-large-european-city
#13
Matthias David, Miriam Alpheus, Heribert Kentenich
INTRODUCTION: Patients usually develop subjective concepts about their illness, which then influences their further health behaviors and treatment decisions. This study aimed to evaluate several possible patient beliefs about the causal factors of illness, in a large sample of women seeking treatment for myomas. METHODS: From November 2011 to October 2013, all patients at a specialized myoma clinic in a large European city were surveyed about their beliefs about the causes of myomas...
March 14, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28290008/three-dimensional-numerical-simulations-of-biofilm-dynamics-with-quorum-sensing-in-a-flow-cell
#14
Jia Zhao, Qi Wang
We develop a multiphasic hydrodynamic theory for biofilms taking into account interactions among various bacterial phenotypes, extracellular polymeric substance (EPS), quorum sensing (QS) molecules, solvent, and antibiotics. In the model, bacteria are classified into down-regulated QS, up-regulated QS, and non-QS cells based on their QS ability. The model is first benchmarked against an experiment yielding an excellent fit to experimental measurements on the concentration of QS molecules and the cell density during biofilm development...
March 13, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28289212/sediment-supply-controls-equilibrium-channel-geometry-in-gravel-rivers
#15
Allison M Pfeiffer, Noah J Finnegan, Jane K Willenbring
In many gravel-bedded rivers, floods that fill the channel banks create just enough shear stress to move the median-sized gravel particles on the bed surface (D50). Because this observation is common and is supported by theory, the coincidence of bankfull flow and the incipient motion of D50 has become a commonly used assumption. However, not all natural gravel channels actually conform to this simple relationship; some channels maintain bankfull stresses far in excess of the critical stress required to initiate sediment transport...
March 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28288637/exploring-implementation-practices-in-results-based-financing-the-case-of-the-verification-in-benin
#16
Matthieu Antony, Maria Paola Bertone, Olivier Barthes
BACKGROUND: Results-based financing (RBF) has been introduced in many countries across Africa and a growing literature is building around the assessment of their impact. These studies are usually quantitative and often silent on the paths and processes through which results are achieved and on the wider health system effects of RBF. To address this gap, our study aims at exploring the implementation of an RBF pilot in Benin, focusing on the verification of results. METHODS: The study is based on action research carried out by authors involved in the pilot as part of the agency supporting the RBF implementation in Benin...
March 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28287225/the-ideal-strength-of-two-dimensional-stanene-may-reach-or-exceed-the-griffith-strength-estimate
#17
Zhe Shi, Chandra Veer Singh
Ideal strength is the maximum stress a material can withstand, and it is an important intrinsic property for structural applications. A Griffith strength limit of ∼E/9 is the best known upper bound of this property for a material loaded in tension. Here we report that stanene, a recently fabricated two-dimensional material, could approach and possibly exceed this limit from a theoretical perspective. Utilizing first-principles density functional theory, we investigated the nonlinear elastic behavior of stanene and found that its strength could reach ∼E/7...
March 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28280737/bioinformatics-study-of-structural-patterns-in-plant-microrna-precursors
#18
J Miskiewicz, K Tomczyk, A Mickiewicz, J Sarzynska, M Szachniuk
According to the RNA world theory, RNAs which stored genetic information and catalyzed chemical reactions had their contribution in the formation of current living organisms. In recent years, researchers studied this molecule diversity, i.a. focusing on small non-coding regulatory RNAs. Among them, of particular interest is evolutionarily ancient, 19-24 nt molecule of microRNA (miRNA). It has been already recognized as a regulator of gene expression in eukaryotes. In plants, miRNA plays a key role in the response to stress conditions and it participates in the process of growth and development...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28278737/the-tell-tale-heart-physiological-reactivity-during-resolution-of-ambiguity-in-youth-anxiety
#19
Michelle Rozenman, Allison Vreeland, Marisela Iglesias, Melissa Mendez, John Piacentini
In the past decade, cognitive biases and physiological arousal have each been proposed as mechanisms through which paediatric anxiety develops and is maintained over time. Preliminary studies have found associations between anxious interpretations of ambiguity, physiological arousal, and avoidance, supporting theories that link cognition, psychophysiology, and behaviour. However, little is known about the relationship between youths' resolutions of ambiguity and physiological arousal during acute stress. Such information may have important clinical implications for use of verbal self-regulation strategies and cognitive restructuring during treatments for paediatric anxiety...
February 16, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28275727/extreme-warmth-and-heat-stressed-plankton-in-the-tropics-during-the-paleocene-eocene-thermal-maximum
#20
Joost Frieling, Holger Gebhardt, Matthew Huber, Olabisi A Adekeye, Samuel O Akande, Gert-Jan Reichart, Jack J Middelburg, Stefan Schouten, Appy Sluijs
Global ocean temperatures rapidly warmed by ~5°C during the Paleocene-Eocene Thermal Maximum (PETM; ~56 million years ago). Extratropical sea surface temperatures (SSTs) met or exceeded modern subtropical values. With these warm extratropical temperatures, climate models predict tropical SSTs >35°C-near upper physiological temperature limits for many organisms. However, few data are available to test these projected extreme tropical temperatures or their potential lethality. We identify the PETM in a shallow marine sedimentary section deposited in Nigeria...
March 2017: Science Advances
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