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https://www.readbyqxmd.com/read/28224241/stem-cell-mechanical-behaviour-modelling-substrate-s-curvature-influence-during-adhesion
#1
M Vassaux, J L Milan
Recent experiments hint that adherent cells are sensitive to their substrate curvature. It is already well known that cells behaviour can be regulated by the mechanical properties of their environment. However, no mechanisms have been established regarding the influence of cell-scale curvature of the substrate. Using a numerical cell model, based on tensegrity structures theory and the non-smooth contact dynamics method, we propose to investigate the mechanical state of adherent cells on concave and convex hemispheres...
February 21, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28223372/perspectives-of-low-socioeconomic-status-mothers-of-premature-infants
#2
Elizabeth Enlow, Laura J Faherty, Sara Wallace-Keeshen, Ashley E Martin, Judy A Shea, Scott A Lorch
BACKGROUND AND OBJECTIVES: Transitioning premature infants from the NICU to home is a high-risk period with potential for compromised care. Parental stress is high, and families of low socioeconomic status may face additional challenges. Home visiting programs have been used to help this transition, with mixed success. We sought to understand the experiences of at-risk families during this transition to inform interventions. METHODS: Mothers of infants born at <35 weeks' gestation, meeting low socioeconomic status criteria, were interviewed by telephone 30 days after discharge to assess caregiver experiences of discharge and perceptions of home visitors (HVs)...
February 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/28222239/evolutionary-rescue-and-local-adaptation-under-different-rates-of-temperature-increase-a-combined-analysis-of-changes-in-phenotype-expression-and-genotype-frequency-in-paramecium-microcosms
#3
Joshua Killeen, Claire Gougat-Barbera, Sascha Krenek, Oliver Kaltz
Evolutionary Rescue (ER) occurs when populations, which have declined due to rapid environmental change, recover through genetic adaptation. The success of this process and the evolutionary trajectory of the population strongly depend on the rate of environmental change. Here we investigated how different rates of temperature increase (from 23°C to 32°C) affect population persistence and evolutionary change in experimental microcosms of the protozoan Paramecium caudatum. Consistent with theory on ER, we found that those populations experiencing the slowest rate of temperature increase were the least likely to become extinct and tended to be the best adapted to the new temperature environment...
February 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28221139/how-do-stones-form-is-unification-of-theories-on-stone-formation-possible
#4
Victoria Y Bird, Saeed R Khan
There are two basic pathways for formation of calcium based kidney stones. Most idiopathic calcium oxalate (CaOx) stones are formed in association with sub-epithelial plaques of calcium phosphate (CaP), known as Randall's plaques, on renal papillary surfaces. Crystal formation and retention within the terminal collecting ducts, the ducts of Bellini, leading to the formation of Randall's plugs, is the other pathway. Both pathways require supersaturation leading to crystallization, regulated by various crystallization modulators produced in response to changing urinary conditions...
January 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28218249/complexity-variability-assessment-of-nonlinear-time-varying-cardiovascular-control
#5
Gaetano Valenza, Luca Citi, Ronald G Garcia, Jessica Noggle Taylor, Nicola Toschi, Riccardo Barbieri
The application of complex systems theory to physiology and medicine has provided meaningful information about the nonlinear aspects underlying the dynamics of a wide range of biological processes and their disease-related aberrations. However, no studies have investigated whether meaningful information can be extracted by quantifying second-order moments of time-varying cardiovascular complexity. To this extent, we introduce a novel mathematical framework termed complexity variability, in which the variance of instantaneous Lyapunov spectra estimated over time serves as a reference quantifier...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217589/relationship-between-attachment-styles-and-happiness-in-medical-students
#6
Marzyeh Moghadam, Farzin Rezaei, Ebrahim Ghaderi, Negar Rostamian
BACKGROUND: Attachment theory is one of the most important achievements of contemporary psychology. Role of medical students in the community health is important, so we need to know about the situation of happiness and attachment style in these students. OBJECTIVES: This study was aimed to assess the relationship between medical students' attachment styles and demographic characteristics. MATERIALS AND METHODS: This cross-sectional study was conducted on randomly selected students of Medical Sciences in Kurdistan University, in 2012...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28215505/the-aging-micromechanisms-of-alumina-matrix-composite-amc-used-in-total-hip-arthroplasty
#7
Shinji Horie, Yasuhito Takahashi, Takaaki Shishido, Toshinori Masaoka, Toshiyuki Tateiwa, Kengo Yamamoto
BACKGROUND: The aim of the present study is to simulate and better understand the long-term interplay between alumina matrix composite (AMC) femoral head and aqueous environment. In particular, we focused on clarifying the role of alumina grains on zirconia phase stability and mechanical equilibrium in AMC head during aging processes in a clinically-relevant time frame. METHODS: The tested AMC head consists of an alumina matrix (82 vol.%) reinforced by yttria-stabilized zirconia (17 vol...
February 16, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28214750/propagation-of-thickness-shear-waves-in-a-periodically-corrugated-quartz-crystal-plate-and-its-application-exploration-in-acoustic-wave-filters
#8
Peng Li, Li Cheng
The propagation of thickness shear waves in a periodically corrugated quartz crystal plate is investigated in the present paper using a power series expansion technique. In the proposed simulation model, an equivalent continuity of shear stress moment is introduced as an approximation to handle sectional interfaces with abrupt thickness changes. The Bloch theory is applied to simulate the band structures for three different thickness variation patterns. It is shown that the power series expansion method exhibits good convergence and accuracy, in agreement with results by finite element method (FEM)...
February 7, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28214073/older-adults-with-ptsd-brief-state-of-research-and-evidence-based-psychotherapy-case-illustration
#9
Joan M Cook, Elissa McCarthy, Steven R Thorp
Although lifetime exposure to potentially traumatic events among older adults is fairly high, rates of full-blown post-traumatic stress disorder (PTSD) are estimated at about 4.5%, a rate lower than that for middle-aged and young adults. Nevertheless, PTSD seems to be an under-recognized and under-treated condition in older adults. Assessment and treatment can be challenging in this population for various reasons, including potential cognitive or sensory decline and comorbid mental and physical disorders. This article provides highlights of the empirical research on PTSD in late life, including information on its effects on cognition and physical health...
January 4, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28212273/oxidative-stress-in-copd-sources-markers-and-potential-mechanisms
#10
REVIEW
Adam John Anthony McGuinness, Elizabeth Sapey
Markers of oxidative stress are increased in chronic obstructive pulmonary disease (COPD) and reactive oxygen species (ROS) are able to alter biological molecules, signaling pathways and antioxidant molecule function, many of which have been implicated in the pathogenesis of COPD. However, the involvement of ROS in the development and progression of COPD is not proven. Here, we discuss the sources of ROS, and the defences that have evolved to protect against their harmful effects. We address the role that ROS may have in the development and progression of COPD, as well as current therapeutic attempts at limiting the damage they cause...
February 15, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28211923/electrical-and-photocatalytic-properties-of-boron-doped-zno-nanostructure-grown-on-pet-ito-flexible-substrates-by-hydrothermal-method
#11
Wei Wang, Taotao Ai, Qi Yu
Boron-doped zinc oxide sheet-spheres were synthesized on PET-ITO flexible substrates using a hydrothermal method at 90 °C for 5 h. The results of X-ray diffraction and X-ray photoelectron spectroscopy indicated that the B atoms were successfully doped into the ZnO lattice, the incorporation of B led to an increase in the lattice constant of ZnO and a change in its internal stress. The growth mechanism of pure ZnO nanorods and B-doped ZnO sheet-spheres was specifically investigated. The as-prepared BZO/PET-ITO heterojunction possessed obvious rectification properties and its positive turn-on voltage was 0...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211914/eco-evolutionary-feedbacks-can-rescue-cooperation-in-microbial-populations
#12
Clara Moreno-Fenoll, Matteo Cavaliere, Esteban Martínez-García, Juan F Poyatos
Bacterial populations whose growth depends on the cooperative production of public goods are usually threatened by the rise of cheaters that do not contribute but just consume the common resource. Minimizing cheater invasions appears then as a necessary mechanism to maintain these populations. However, that invasions result instead in the persistence of cooperation is a prospect that has yet remained largely unexplored. Here, we show that the demographic collapse induced by cheaters in the population can actually contribute to the rescue of cooperation, in a clear illustration of how ecology and evolution can influence each other...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210913/dietary-and-commercialized-fructose-sweet-or-sour
#13
REVIEW
Aslihan Yerlikaya, Tuncay Dagel, Christopher King, Masanari Kubawara, Miguel A Lanaspa, Ana Andres-Hernando, Adrian Covic, Jacek Manitius, Alan A Sag, Mehmet Kanbay
Metabolic syndrome and diabetes are main health problems of modern life in the twenty-first century. Alarming ratios of global prevalence lead to conduct more and more researches about etiological factors and pathogenesis. Disease mechanism is elementary for advancing more efficient and practicable treatment methods. Concurrent increase in both fructose consumption with Western diet and metabolic syndrome has revealed fructose hypothesis that suggests fructose as one of etiological factor of metabolic syndrome (insulin resistance, central obesity, hypertension, etc...
February 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28209542/social-anxiety-and-the-cortisol-response-to-social-evaluation-in-children-and-adolescents
#14
Esther van den Bos, Mattie Tops, P Michiel Westenberg
Contradictory findings have been reported on the relation between social anxiety and the cortisol response to social evaluation in youth. The present longitudinal study aimed to clarify this relation by taking pubertal development into account. Data were collected in two waves, two years apart, for a community sample of 196 participants, aged 8-17 years at Time 1. Pubertal development and social anxiety were assessed with self-report questionnaires. Salivary cortisol was obtained before and after participants completed the Leiden Public Speaking Task...
February 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28209122/effects-and-meanings-of-a-person-centred-and-health-promoting-intervention-in-home-care-services-a-study-protocol-of-a-non-randomised-controlled-trial
#15
Karin Bölenius, Kristina Lämås, Per-Olof Sandman, David Edvardsson
BACKGROUND: The literature indicates that current home care service are largely task oriented with limited focus on the involvement of the older people themselves, and studies show that lack of involvement might reduce older people's quality of life. Person-centred care has been shown to improve the satisfaction with care and quality of life in older people cared for in hospitals and nursing homes, with limited published evidence about the effects and meanings of person-centred interventions in home care services for older people...
February 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28208450/thermal-effects-in-dislocation-theory-ii-shear-banding
#16
J S Langer
The thermodynamic dislocation theory presented in previous papers is used here to describe shear-banding instabilities. Central ingredients of the theory are a thermodynamically defined effective configurational temperature and a formula for the plastic strain rate determined by thermally activated depinning of entangled dislocations. This plastic strain rate is extremely sensitive to variations of the stress and the ordinary temperature. As a result of this sensitivity, the system undergoes rapid shear banding instabilities when ordinary thermal relaxation is slow...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28206799/military-service-member-and-veteran-reintegration-a-critical-review-and-adapted-ecological-model
#17
Christine A Elnitsky, Cara L Blevins, Michael P Fisher, Kathryn Magruder
Returning military service members and veterans (MSMVs) experience a wide range of stress-related disorders in addition to social and occupational difficulties when reintegrating to the community. Facilitating reintegration of MSMVs following deployment is a societal priority. With an objective of identifying challenges and facilitators for reintegration of MSMVs of the current war era, we critically review and identify gaps in the literature. We searched 8 electronic databases and identified 1,764 articles...
2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28205509/anisotropic-mechanical-and-optical-response-and-negative-poisson-s-ratio-in-mo2c-nanomembranes-revealed-by-first-principles-simulations
#18
Bohayra Mortazavi, Masoud Shahrokhi, Meysam Makaremi, Timon Rabczuk
Transition metal carbides include a wide variety of materials with attractive properties that are suitable for numerous and diverse applications. A most recent experimental advance could provide a path toward the successful synthesis of large-area and high-quality ultrathin Mo2C membranes with superconducting properties. In the present study, we used first-principles density functional theory calculations to explore the mechanical and optical response of single-layer and free-standing Mo2C. Uniaxial tensile simulations along the armchair and zigzag directions were conducted and we found that while the elastic properties are close along various loading directions, the nonlinear regimes in stress-strain curves are considerably different...
February 16, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28203207/morphotype-dependent-flow-characteristics-in-bicuspid-aortic-valve-ascending-aortas-a-benchtop-particle-image-velocimetry-study
#19
Andrew McNally, Ashish Madan, Philippe Sucosky
The bicuspid aortic valve (BAV) is a major risk factor for secondary aortopathy such as aortic dilation. The heterogeneous BAV morphotypes [left-right-coronary cusp fusion (LR), right-non-coronary cusp fusion (RN), and left-non-coronary cusp fusion (LN)] are associated with different dilation patterns, suggesting a role for hemodynamics in BAV aortopathogenesis. However, assessment of this theory is still hampered by the limited knowledge of the hemodynamic abnormalities generated by the distinct BAV morphotypes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28199429/-emotional-processing-theory-and-prolonged-exposure-therapy-for-posttraumatic-stress-disorder
#20
Rafael Kichic, Noelí D'Alessio
Prolonged exposure therapy is a first-line treatment for posttraumatic stress disorder. In this article we discuss the theoretical underpinnings and underlying mechanisms of PE, its efficacy and safety. We briefly describe the procedures involved in PE with special emphasis in imaginal exposure. Also, we present examples of efforts to integrate evidence-based treatments that concurrently target PTSD and borderline personality disorder. Next, we review efforts made to adapt the intervention to Hispanics. Finally, obstacles for disseminating and implementing PE are discussed...
March 2016: Vertex: Revista Argentina de Psiquiatriá
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