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HSP 72 AND HIF

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https://www.readbyqxmd.com/read/17645928/heat-acclimation-and-cross-tolerance-against-novel-stressors-genomic-physiological-linkage
#1
REVIEW
Michal Horowitz
Heat acclimation (AC) is a "within lifetime" reversible phenotypic adaptation, enhancing thermotolerance and heat endurance via a transition to "efficient" cellular performance when acclimatory homeostasis is reached. An inseparable outcome of AC is the development of cross-tolerance (C-T) against novel stressors. This chapter focuses on central plasticity and the molecular-physiological linkage of acclimatory and C-T responses. A drop in temperature thresholds (T-Tsh) for activation of heat-dissipation mechanisms and an elevated T-Tsh for thermal injury development imply autonomic nervous system (ANS) and cytoprotective network involvement in these processes...
2007: Progress in Brain Research
https://www.readbyqxmd.com/read/12122984/-regulatory-mechanisms-in-focal-cerebral-ischemia-new-possibilities-in-neuroprotective-therapy
#2
REVIEW
Zoltán Nagy, László Simon, Zoltán Bori
Permanent or temporary disruption of cerebral blood flow rapidly depletes brain regions of their limited energy reserves (glycogen, glucose, oxygen, ATP) leading to an energy crisis. Tissue damage occurs due to the energy crisis. The central part of the damage, the ischaemic "core" region is surrounded by zones of the shell-like penumbra. Necrotic, as well as apoptotic cell death could be identified in the penumbra. Going away from the ischaemic core different neurochemical processes are occurring by space and time...
March 20, 2002: Ideggyógyászati Szemle
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