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Uremic pruritus

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https://www.readbyqxmd.com/read/28328802/curative-effect-of-neutral-macroporous-resin-hemoperfusion-on-treating-hemodialysis-patients-with-refractory-uremic-pruritus
#1
RANDOMIZED CONTROLLED TRIAL
Wen-Hong Li, Yu-Min Yin, Hao Chen, Xiao-Dan Wang, He Yun, Hui Li, Jie Luo, Jin-Wen Wang
This study aims to investigate the efficacy and safety of neutral macroporous resin hemoperfusion in treating maintenance hemodialysis (MHD) patients with refractory uremic pruritus (RUP).Ninety patients were enrolled and were randomly divided into 3 groups: control group, experiment 1 group, and experiment 2 group. Clinical symptom scores of skin itching were recorded before and at 4 and 8 weeks after the treatment. In addition, serum parathyroid hormone (PTH), calcium (Ca), phosphorus (P), and C-reactive protein (CRP) were detected; and the calcium-phosphorus product ([Ca] × [P]) was calculated to compare the curative effect...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28263039/sertraline-can-reduce-the-uremic-pruritus-in-hemodialysis-patient-a-double-blind-randomized-clinical-trial-from-southern-iran
#2
Maryam Pakfetrat, Leila Malekmakan, Noushin Hashemi, Taraneh Tadayon
INTRODUCTION: Uremic pruritus is an undesirable complication of end stage renal disease (ESRD). In spite of introduction of many treatments for this complication, it has no certain cure. The aim of this study was to assess sertraline effect on uremic pruritus. METHODS: In the present clinical trial study, we randomly divided our patients into two groups; trial group that received sertraline and control group that consumed placebo. We measured the severity of pruritus by two scoring systems (visual analogue scale and DUO) at the beginning and during the study with a-2-week interval...
March 6, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28260912/association-of-uremic-pruritus-in-hemodialysis-patients-with-the-number-of-days-of-high-mean-24-hour-particulate-matter-with-a-diameter-of-2-5-%C3%AE-m
#3
Ming-Hui Liu, Ming-Jen Chan, Ching-Wei Hsu, Cheng-Hao Weng, Tzung-Hai Yen, Wen-Hung Huang
Uremic pruritus (UP) is a common and incapacitating symptom in patients undergoing hemodialysis (HD). The pathogenesis of UP is multifactorial and complex. Particulate matter (PM), a major air pollutant, is a mixture of particles with various chemical compositions. PM is associated with several allergic diseases, including dermatitis. To assess the role of PM (PM with a diameter of <10 μm [PM10] and PM with a diameter of <2.5 μm [PM2.5]) and other clinical variables in UP in patients on HD, we recruited 866 patients on maintenance HD (MHD)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28183080/total-calcium-and-albumin-are-decreased-in-the-deeper-epidermis-of-patients-with-chronic-kidney-disease-associated-pruritus
#4
Akishi Momose, Yasuo Shiraiwa, Satoshi Narita, Tomomi Kusumi, Shoko Goto, Koichiro Sera
BACKGROUND/AIMS: In our earlier studies, we reported high concentrations of intra- and extracellular calcium ions (Ca2+) in the deeper epidermis of patients with chronic kidney disease (CKD) and associated pruritus. To determine the cause of this phenomenon, we measured total calcium (TCa) concentrations in the deeper epidermis and performed immunostaining of epidermal albumin, which binds to Ca2+. METHODS: This study included 45 patients with CKD-stage 5, which was defined as severely reduced kidney function (i...
February 10, 2017: Nephron
https://www.readbyqxmd.com/read/28148557/symptom-management-of-the-patient-with-ckd-the-role-of-dialysis
#5
Valerie Jorge Cabrera, Joni Hansson, Alan S Kliger, Fredric O Finkelstein
As kidney disease progresses, patients often experience a variety of symptoms. A challenge for the nephrologist is to help determine if these symptoms are related to advancing CKD or the effect of various comorbidities and/or medications prescribed. The clinician also must decide the timing of dialysis initiation. The initiation of dialysis can have a variable effect on quality of life measures and the alleviation of uremic signs and symptoms, such as anorexia, fatigue, cognitive impairment, depressive symptoms, pruritus, and sleep disturbances...
April 3, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28101457/therapeutic-effects-of-omega-3-fatty-acids-on-chronic-kidney-disease-associated-pruritus-a-literature-review
#6
REVIEW
Yunes Panahi, Simin Dashti-Khavidaki, Farahnoosh Farnood, Hamid Noshad, Mahsa Lotfi, Afshin Gharekhani
Uremic pruritus remains one of the most tormenting, frequent and potentially disabling problem in chronic kidney disease (CKD) patients. However, an area of substantial etiological interest with relation to uremic pruritus is the essential fatty acids deficiency. So we performed a literature review to elucidate the efficacy of omega-3 fatty acids on uremic pruritus. This review evaluated all of the studies published in English language, focusing on the clinical effects of omega-3 fatty acids on uremic pruritus...
December 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28057164/role-of-pregabalin-in-management-of-pruritus-a-literature-review
#7
Nazanin Foroutan, Naemeh Nikvarz
Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Itch sensation is transferred to the central nervous system via unmyelinated C-type nerve fibers, and many mediators and receptors engage in the its induction and transmission. Also it has been demonstrated that there are similarities and interactions between neurotransmitters and pathways of pain and itch sensation...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28012182/development-of-a-multidimensional-assessment-tool-for-uremic-pruritus-in-dialysis-patients-up-dial
#8
S Nochaiwong, C Ruengorn, R Awiphan, S Panyathong, K Noppakun, W Chongruksut, S Chiewchanvit
BACKGROUND: Dialysis patients with uremic pruritus (UP) have a significantly impaired quality of life. To assess the therapeutic effect of UP treatments, a well-validated comprehensive and multidimensional instrument needed to be established. OBJECTIVES: To develop and validate a multidimensional scale assessing the UP in dialysis patients: Uremic Pruritus in Dialysis Patients (UP-Dial). METHODS: The development and validation of the UP-Dial instrument was conducted in four phases: (1) item generation, (2) development of pilot questionnaire, (3) refinement of questionnaire with patient recruitment, and (4) psychometric validation...
December 23, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27824127/an-observational-longitudinal-study-investigating-the-effectiveness-of-75%C3%A2-mg-pregabalin-post-hemodialysis-among-uremic-pruritus-patients
#9
Tahir Mehmood Khan, David Bin-Chia Wu, Bey-Hing Goh, Learn-Han Lee, Abdul Aziz Alhafez, Syed Azhar Syed Sulaiman
A prospective, observational, longitudinal study was conducted to assess the effectiveness of 75 mg pregabalin (PG) post-hemodialysis (pHD) for treatment-resistant uremic pruritus (UP). A total of forty-five patients completed the entire six week follow-up. At the baseline assessment, the majority of the patients were distressed by the UP frequency and intensity. Sleep (mean = 3.30 ± 1.1), leisure/social activities (mean = 2.90 ± 0.80) and distribution (mean = 2.92 ± 0.34) were the three domains that were primarily effected by the UP...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27693261/sleep-disorders-restless-legs-syndrome-and-uremic-pruritus-diagnosis-and-treatment-of-common-symptoms-in-dialysis%C3%A2-patients
#10
Jennifer S Scherer, Sara A Combs, Frank Brennan
Maintenance dialysis patients experience a high burden of physical and emotional symptoms that directly affect their quality of life and health care utilization. In this review, we specifically highlight common troublesome symptoms affecting dialysis patients: insomnia, restless legs syndrome, and uremic pruritus. Epidemiology, pathophysiology, and evidence-based current treatment are reviewed with the goal of providing a guide for diagnosis and treatment. Finally, we identify multiple additional areas of further study needed to improve symptom management in dialysis patients...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27687138/reply-to-gabapentin-a-promising-therapy-for-uremic-pruritus-in-hemodialysis-patients-a-randomized-controlled-trial-and-review-of-literature
#11
Berna Solak, Yalcin Solak
No abstract text is available yet for this article.
August 10, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27617950/uremic-pruritus-treated-successfully-with-the-goeckerman-program
#12
Mio Nakamura, John Koo, Tina Bhutani
Uremic pruritus (UP) is a common condition among patients with chronic kidney disease (CKD) on hemodialysis (HD). We report 19 a case of severe UP recalcitrant to conventional therapy including topical corticosteroids, anti-histamines, and phototherapy, 20 which was treated successfully with the Goeckerman regimen consisting of topical coal tar, topical corticosteroids, and broadband 21 UVB (BB-UVB). Little is known about the pathophysiology of UP, and there is currently no consensus or evidence-based 22 treatments for UP...
August 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27578082/uremic-itch-management
#13
REVIEW
Thomas Mettang
Uremic itch is a frequent and sometimes very tormenting symptom in patients with advanced or end-stage renal failure, with a strong negative impact on the quality of life. According to a representative study, the point prevalence of chronic itch is 25% in hemodialysis patients but may reach more than 50% in single cohorts depending on the country and dialysis efficacy. Not much is known regarding the pathogenesis of uremic itch. Besides parathyroid hormone, histamine, tryptase, and alteration of the calcium-phosphate metabolism have been suspected...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27578074/itch-management-treatments-under-development
#14
REVIEW
Manuel Pedro Pereira, Sonja Ständer
Pruritus is a symptom arising from a plethora of dermatological, neurological, and systemic conditions. The pathophysiological mechanisms involved in the transmission of acute and chronic pruritus are of high complexity and not yet fully understood. Recent research has enhanced the understanding of these mechanisms, enabling the development of novel drugs. Specifically, new therapies for inflammatory dermatoses, uremic pruritus, cholestatic pruritus, cutaneous T-cell lymphoma, and prurigo nodularis are being tested in ongoing randomized clinical trials...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27557426/sertraline-as-an-additional-treatment-for-cholestatic-pruritus-in-children
#15
Alice Thébaut, Dalila Habes, Frédéric Gottrand, Christine Rivet, Joseph Cohen, Dominique Debray, Emmanuel Jacquemin, Emmanuel Gonzales
BACKGROUNDS/AIM: Pruritus is a severe symptom accompanying chronic cholestasis. It can be debilitating and difficult to control. In children, first-line treatments are ursodeoxycholic acid and rifampicin. Refractory pruritus may require invasive therapies including liver transplantation. Clinical trials based on small samples of adult patients suggest that serotonin reuptake inhibitors can improve pruritus in cholestatic or uremic disease. We performed a prospective, multicenter study to assess efficiency and safety of the serotonin reuptake inhibitor sertraline in treating children with refractory cholestatic pruritus...
August 24, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27507591/environmental-no2-and-co-exposure-ignored-factors-associated-with-uremic-pruritus-in-patients-undergoing-hemodialysis
#16
Wen-Hung Huang, Jui-Hsiang Lin, Cheng-Hao Weng, Ching-Wei Hsu, Tzung-Hai Yen
Uremic pruritus (UP), also known as chronic kidney disease-associated pruritus, is a common and disabling symptom in patients undergoing maintenance hemodialysis (MHD). The pathogenesis of UP is multifactorial and poorly understood. Outdoor air pollution has well-known effects on the health of patients with allergic diseases through an inflammatory process. Air pollution-induced inflammation could occur in the skin and aggravate skin symptoms such as pruritus or impair epidermal barrier function. To assess the role of air pollutants, and other clinical variables on uremic pruritus (UP) in HD patients, we recruited 866 patients on maintenance HD...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27448750/loss-of-papillary-dermal-calcitonin-gene-related-peptide-expressing-neurons-significantly-correlates-with-uremic-pruritus
#17
Tiankai Du, A Bar-Hen, Jasvinder S Bhatia, Deon Wolpowitz
No abstract text is available yet for this article.
July 20, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27397522/comparison-of-pregabalin-with-doxepin-in-the-management-of-uremic-pruritus-a-randomized-single-blind-clinical-trial
#18
Nazanin Foroutan, Abbas Etminan, Naemeh Nikvarz, Mohadese Shojai Shahrokh Abadi
Introduction Pruritus is one of the frustrating skin manifestations of advanced renal failure. Many options have been used for the management of uremic pruritus (UP) such as pregabalin. There are some studies that reported beneficial effects of pregabalin in reducing UP; however, most of them did not have a comparator arm. Therefore, we designed this study to compare antipruritic effects of pregabalin with doxepin in the management of pruritus in hemodialysis patients. Methods Seventy-two patients suffering from UP were randomly assigned to receive pregabalin (50 mg every other day) or doxepin (10 mg per day) for 4 weeks...
July 11, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27376752/-pruritus-in-systemic-diseases-common-and-rare-etiologies
#19
REVIEW
A E Kremer, T Mettang
Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching may cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scaring. The most common internal medicine causes for chronic pruritus are chronic kidney disease, hepatobiliary and hematological disorders as well as adverse drug reactions. Pruritus is less commonly seen in patients with endocrine or metabolic diseases, malabsorption syndromes, infectious diseases and solid tumors...
August 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27366666/comparison-of-uremic-pruritus-between-patients-undergoing-hemodialysis-and-peritoneal-dialysis
#20
Ji-Won Min, Su-Hyun Kim, Young Ok Kim, Dong Chan Jin, Ho Chul Song, Euy Jin Choi, Yong-Lim Kim, Yon-Su Kim, Shin-Wook Kang, Nam-Ho Kim, Chul Woo Yang, Yong Kyun Kim
BACKGROUND: Uremic pruritus is a common, but unpleasant, complication of end-stage renal disease. The uremic burden may differ between hemodialysis (HD) and peritoneal dialysis (PD) patients. This difference may also change the clinical characteristics of uremic pruritus between the 2 modalities. In this study, we investigated the uremic pruritus between patients on HD and PD. METHODS: A total of 425 HD and 223 PD patients from the Clinical Research Center registry in Korea were included...
June 2016: Kidney Research and Clinical Practice
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