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Uremic pruritis

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https://www.readbyqxmd.com/read/24291743/uremic-toxin-indoxyl-3-sulfate-regulates-the-differentiation-of-th2-but-not-of-th1-cells-to-lessen-allergic-asthma
#1
You-Jung Hwang, Mi-Ok Yun, Kyu-Tae Jeong, Joo-Hung Park
Immune system dysfunctions including the increased Th1/Th2 ratio are common in chronic kidney disease (CKD) patients, and a wide variety of skin diseases including Th1-mediated uremic pruritis are associated with CKD. Although there are more than 90 uremic toxins reported, it is yet to be known which uremic solute is associated with the unbalanced Th1/Th2 ratio and how it works. Indoxyl 3-sulfate (I3S), one of uremic toxins and a potent aryl hydrocarbon receptor (AhR) ligand, accumulates in blood and tissues, increasing up to 81...
February 10, 2014: Toxicology Letters
https://www.readbyqxmd.com/read/22556282/gabapentin-for-pruritus-in-palliative-care
#2
REVIEW
Sheeba Anand
Itch/pruritus can be very distressing in palliative care population and often is difficult to treat. Conventional antihistamines lack efficacy. Cutaneous and central pathogenesis of itch is extremely complex and unclear, making its treatment challenging. Neuronal mechanisms have been identified in the pathophysiology of itch hence providing a myriad of therapeutic options. It has been established that pruritus and pain neuronal pathway interact with each other, hence neuropathic analgesics like gabapentin has shown to be efficacious antipruritic therapeutic option...
March 2013: American Journal of Hospice & Palliative Care
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