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https://www.readbyqxmd.com/read/27910708/myo-inositol-and-melatonin-in-the-menopausal-transition
#1
Rosario D'Anna, Angelo Santamaria, Grazia Giorgianni, Alberto Vaiarelli, Giuseppe Gullo, Flavia Di Bari, Salvatore Benvenga
INTRODUCTION: The aim of the study was to evaluate the effects on serum insulin and serum thyroid profile of a dietary supplement, myo-inositol, given alone or in combination with melatonin to women during menopausal transition. METHODS: Forty women aged 45-55 years and at least 6 months of amenorrhea were enrolled in this study. They were randomly assigned to two groups of 20 each. One group took myo-inositol (myo-Ins) (2 g twice a day) and the other group took 2 g/d myo-Ins plus 3 g/d melatonin before sleeping...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27904735/urinary-metabolomics-of-young-italian-autistic-children-supports-abnormal-tryptophan-and-purine-metabolism
#2
Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico
BACKGROUND: Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines and plasma of ASD and control individuals, suggested that autistic patients may share some metabolic abnormalities, despite several inconsistencies stemming from differences in technology, ethnicity, age range, and definition of "control" status...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27887821/-sleep-disorders-in-internet-addiction
#3
Aymeric Petit, Laurent Karila, Candice Estellat, Delphine Moisan, Michel Reynaud, Marie-Pia D'Ortho, Michel Lejoyeux, Fanny Levy
BACKGROUND: The relationship between sleep disorders and Internet addiction has been little work. Given the importance of these disorders, we felt it appropriate to make a synthesis of available data and to establish causality or accountability between Internet addiction and the onset of sleep disorders. METHODS: A literature review was then performed. We selected scientific articles in English and French, published between 1987 and 2016 by consulting the databases Medline, Embase, PsycINFO and Google Scholar...
November 22, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27868260/an-experimental-study-of-adolescent-sleep-restriction-during-a-simulated-school-week-changes-in-phase-sleep-staging-performance-and-sleepiness
#4
Alex Agostini, Mary A Carskadon, Jillian Dorrian, Scott Coussens, Michelle A Short
This laboratory study investigated the impact of restricted sleep during a simulated school week on circadian phase, sleep stages and daytime functioning. Changes were examined across and within days and during a simulated weekend recovery. Participants were 12 healthy secondary school students (six male) aged 15-17 years [mean = 16.1 years, standard deviation (SD) = 0.9]. After 2 nights with 10 h (21:30-07:30 hours), time in bed was restricted to 5 h for 5 nights (02:30-07:30 hours), then returned to 10 h time in bed for 2 nights (21:30-07:30 hours)...
November 21, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27868193/no-pattern-alteration-in-single-nocturnal-melatonin-secretion-in-patients-with-hypnic-headache-a-case-control-study
#5
Steffen Naegel, Jana-Isabel Huhn, Charly Gaul, Hans-Christoph Diener, Mark Obermann, Dagny Holle
OBJECTIVE: To investigate headache-related serum melatonin levels and melatonin excretion rhythmicity in patients with hypnic headache (HH). BACKGROUND: Strict sleep dependency of headache attacks is a pathognomonic feature of HH. Changes in melatonin levels, a marker for circadian rhythm, are assumed to play a pivotal role in the pathophysiology of HH. METHODS: Serum melatonin levels were acquired in nine patients with HH and nine age- and gender-matched healthy controls over a 20-hour time period (12 pm, 4 pm, 7 pm, 10 pm, time of headache, and 8 am)...
November 21, 2016: Headache
https://www.readbyqxmd.com/read/27865517/effects-of-melatonin-in-the-treatment-of-asthenia-in-aneurysmal-subarachnoid-hemorrhage
#6
V Gilard, F-X Ferracci, O Langlois, S Derrey, F Proust, S Curey
BACKGROUND AND OBJECTIVES: Survivors of aneurysmal subarachnoid hemorrhage (aSAH) commonly experience sleep disorders resulting in asthenia. The objective of this prospective study was to determine, in a cohort of patients with treated ruptured intracranial aneurysm (IA), the proportion of asthenia at 2months, in a cohort of patients treated with melatonin and in a control cohort. PATIENTS AND METHODS: Twenty consecutive patients admitted for the treatment of ruptured IA and able to answer a standardized questionnaire were included in the study...
December 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27858294/sleep-quality-morningness-eveningness-preference-mood-profile-and-levels-of-serum-melatonin-in-migraine-patients-a-case-control-study
#7
Hasan Hüseyin Kozak, Murat Boysan, Ali Ulvi Uca, Adem Aydın, İbrahim Kılınç, Emine Genç, Mustafa Altaş, Dilara Cari Güngör, Keziban Turgut, Nejla Özer
The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature...
November 17, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27855744/melatonin-natural-health-products-and-supplements-presence-of-serotonin-and-significant-variability-of-melatonin-content
#8
Lauren A E Erland, Praveen K Saxena
STUDY OBJECTIVES: Melatonin is an important neurohormone, which mediates circadian rhythms and the sleep cycle. As such, it is a popular and readily available supplement for the treatment and prevention of sleep-related disorders including insomnia and jet lag. This study quantified melatonin in 30 commercial supplements, comprising different brands and forms and screened supplements for the presence of serotonin. METHODS: A total of 31 supplements were analyzed by ultraperformance liquid chromatography with electrochemical detection for quantification of melatonin and serotonin...
November 14, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27851868/pharmacotherapies-for-sleep-disturbances-in-dementia
#9
REVIEW
Jenny McCleery, Daniel A Cohen, Ann L Sharpley
BACKGROUND: Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering, and daytime sleepiness are common clinical problems in dementia, and are associated with significant caregiver distress, increased healthcare costs, and institutionalisation. Drug treatment is often sought to alleviate these problems, but there is significant uncertainty about the efficacy and adverse effects of the various hypnotic drugs in this vulnerable population. OBJECTIVES: To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia, through identification and analysis of all relevant randomised controlled trials (RCTs)...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27829983/melatoninergic-system-in-parkinson-s-disease-from-neuroprotection-to-the-management-of-motor-and-nonmotor-symptoms
#10
REVIEW
Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P Markus, Rui Daniel Prediger
Melatonin is synthesized by several tissues besides the pineal gland, and beyond its regulatory effects in light-dark cycle, melatonin is a hormone with neuroprotective, anti-inflammatory, and antioxidant properties. Melatonin acts as a free-radical scavenger, reducing reactive species and improving mitochondrial homeostasis. Melatonin also regulates the expression of neurotrophins that are involved in the survival of dopaminergic neurons and reduces α-synuclein aggregation, thus protecting the dopaminergic system against damage...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27829954/the-effects-of-ramelteon-on-glucose-metabolism-and-sleep-quality-in-type-2-diabetic-patients-with-insomnia-a-pilot-prospective-randomized-controlled-trial
#11
Tetsuji Tsunoda, Masayo Yamada, Tomoaki Akiyama, Taichi Minami, Taishi Yoshii, Yoshinobu Kondo, Shinobu Satoh, Yasuo Terauchi
BACKGROUND: Insomnia is associated with the onset and development of diabetes. Melatonin affects sleep quality and glucose metabolism in diabetic patients with insomnia. We administered ramelteon, an agonist of melatonin, to type 2 diabetic patients and investigated its effects on glucose metabolism and insomnia. METHODS: This multicenter, prospective, randomized, and observational pilot study was performed between April 2014 and April 2015 at three institutes in Japan...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27821114/bright-light-therapy-in-pregnant-women-with-major-depressive-disorder-study-protocol-for-a-randomized-double-blind-controlled-clinical-trial
#12
Babette Bais, Astrid M Kamperman, Marjolein D van der Zwaag, Gwen C Dieleman, Hanneke W Harmsen van der Vliet-Torij, Hilmar H Bijma, Ritsaert Lieverse, Witte J G Hoogendijk, Mijke P Lambregtse-van den Berg
BACKGROUND: Depression during pregnancy is a common and high impact disease. Generally, 5-10 % of pregnant women suffer from depression. Children who have been exposed to maternal depression during pregnancy have a higher risk of adverse birth outcomes and more often show cognitive, emotional and behavioural problems. Therefore, early detection and treatment of antepartum depression is necessary. Both psychotherapy and antidepressant medication, first choice treatments in a non-pregnant population, have limitations in treating depression during pregnancy...
November 8, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27812851/pineal-volume-and-evening-melatonin-in-young-people-with-affective-disorders
#13
Joanne S Carpenter, Amy C Abelmann, Sean N Hatton, Rébecca Robillard, Daniel F Hermens, Maxwell R Bennett, Jim Lagopoulos, Ian B Hickie
Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize these factors and explore associations with mood symptoms and functioning in a sample of young people with affective disorders...
November 3, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27797990/cohort-profile-the-baependi-heart-study-a-family-based-highly-admixed-cohort-study-in-a-rural-brazilian-town
#14
Kieren J Egan, Malcolm von Schantz, André B Negrão, Hadassa C Santos, Andréa R V R Horimoto, Nubia E Duarte, Guilherme C Gonçalves, Júlia M P Soler, Mariza de Andrade, Geraldo Lorenzi-Filho, Homero Vallada, Tâmara P Taporoski, Mario Pedrazzoli, Ana P Azambuja, Camila M de Oliveira, Rafael O Alvim, José E Krieger, Alexandre C Pereira
PURPOSE: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits...
October 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27795550/circadian-timing-and-alignment-in-healthy-adults-associations-with-bmi-body-fat-caloric-intake-and-physical-activity
#15
K G Baron, K J Reid, T Kim, L Van Horn, H Attarian, L Wolfe, J Siddique, G Santostasi, P C Zee
INTRODUCTION: Disruption of circadian rhythms is one of the proposed mechanisms linking late sleep timing to obesity risk but few studies have evaluated biological markers outside of the laboratory. The goal of this study was to determine the relationship between the timing and alignment of melatonin and sleep onset (phase angle) with BMI, body fat and obesity related behaviors. We hypothesized that circadian alignment (relationship of melatonin to sleep timing) rather than circadian (melatonin) timing would be associated with higher BMI, body fat, dietary intake and lower physical activity...
October 31, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27769202/a-double-blind-randomized-controlled-trial-to-assess-the-effect-of-bright-light-therapy-on-depression-in-patients-with-parkinson-s-disease
#16
Sonja Rutten, Chris Vriend, Jan H Smit, Henk W Berendse, Adriaan W Hoogendoorn, Odile A van den Heuvel, Ysbrand D van der Werf
BACKGROUND: A disturbed circadian rhythm seems to be a causal factor in the occurrence of depressive disorders in patients with Parkinson's disease (PD). The circadian rhythm can be restored with light. Therefore, Bright Light Therapy (BLT) might be a new treatment option for depression in PD patients. METHODS/DESIGN: In this double-blind controlled trial, 84 subjects with idiopathic PD are randomized to either BLT or a control light condition. The BLT condition emits white light with an intensity of 10,000 Lux, while the control device emits dim white light of 200 Lux, which is presumed to be too low to influence the circadian rhythm...
October 21, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27761038/a-comparison-of-the-effect-of-two-doses-of-oral-melatonin-with-oral-midazolam-and-placebo-on-pre-operative-anxiety-cognition-and-psychomotor-function-in-children-a-randomised-double-blind-study
#17
Madhuri S Kurdi, Sindhu Priya Muthukalai
BACKGROUND AND AIMS: Melatonin (MT), a naturally occurring pituitary hormone has a sleep promoting effect. There are very few studies on pre-operative oral MT (0.2-0.5 mg/kg) in children. We planned a study to assess the efficacy of oral MT in two doses and compare it with oral midazolam and placebo for pre-operative anxiolysis, sedation, maintenance of cognition and psychomotor skills, parental separation behaviour and venepuncture compliance. METHODS: This prospective double-blind randomised study was conducted after ethical committee approval on 100 children aged 5-15 years, American Society of Anaesthesiologists physical status I and II undergoing elective surgery at our hospital from January 1, 2014, to December 31, 2014...
October 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/27752878/treatment-of-rem-sleep-behavior-disorder
#18
Youngsin Jung, Erik K St Louis
REM sleep behavior disorder (RBD) is a common parasomnia disorder affecting between 1 and 7 % of community-dwelling adults, most frequently older adults. RBD is characterized by nocturnal complex motor behavior and polysomnographic REM sleep without atonia. RBD is strongly associated with synucleinopathy neurodegeneration. The approach to RBD management is currently twofold: symptomatic treatment to prevent injury and prognostic counseling and longitudinal follow-up surveillance for phenoconversion toward overt neurodegenerative disorders...
November 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27751669/review-of-safety-and-efficacy-of-sleep-medicines-in-older-adults
#19
REVIEW
Jennifer L Schroeck, James Ford, Erin L Conway, Kari E Kurtzhalts, Megan E Gee, Krista A Vollmer, Kari A Mergenhagen
PURPOSE: Insomnia is problematic for older adults. After behavioral modifications fail to show adequate response, pharmacologic options are used. The pharmacokinetics of agents used to treat insomnia may be altered. This review focuses on the safety and efficacy of medications used to treat insomnia. METHODS: A literature search of Medline, PubMed, and Embase was conducted (January 1966-June 2016). It included systematic reviews, randomized controlled trials, observational studies, and case series that had an emphasis on insomnia in an older population...
November 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27748241/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomised-controlled-study
#20
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
STUDY OBJECTIVES: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
October 10, 2016: Sleep
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