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Melatonin sleep

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https://www.readbyqxmd.com/read/29660304/circadian-rhythm-resynchronization-improved-isoflurane-induced-cognitive-dysfunction-in-aged-mice
#1
Jia Song, Shuaishuai Chu, Yin Cui, Yue Qian, Xiuxiu Li, Fangxia Xu, Xueming Shao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Postoperative cognitive dysfunction (POCD) is a common clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery. Advanced age is a significant independent risk factor for POCD. We previously reported that in young mice, sleep-wake rhythm is involved in the isoflurane-induced memory impairment. In present study, we sought to determine whether advanced age increased the risk of POCD through aggravated and prolonged post-anesthetic circadian disruption in the elderly. We constructed POCD model by submitting the mice to 5-h 1...
April 13, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29656092/sleep-deprivation-impairs-cognitive-performance-in-zebrafish-a-matter-of-fact
#2
Jaquelinne Pinheiro-da-Silva, Steven Tran, Ana Carolina Luchiari
The zebrafish (Danio rerio) has become a valuable model organism for behavioral studies examining learning and memory. Its diurnal circadian rhythm and characterized sleep-like state make it comparable to mammals, features that have contributed to establishing this small vertebrate as a translational model for sleep research. Despite sleep being an evolutionarily conserved behavior, its mechanisms and functions are still debated. Sleep deprivation is commonly associated with decreased attention, reduced responsiveness to external stimuli, altered locomotor activity and impaired performance on cognitive tasks...
April 12, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29649764/sleep-after-intranasal-progesterone-vs-zolpidem-and-placebo-in-postmenopausal-women-a-randomized-double-blind-cross-over-study
#3
P Schüssler, M Kluge, M Adamczyk, M E Beitinger, P Beitinger, A Bleifuss, S Cordeiro, C Mattern, M Uhr, T C Wetter, A Yassouridis, R Rupprecht, E Friess, A Steiger
CONTEXT: The loss of progesterone during menopause is linked to sleep complaints of the affected women. Previously we demonstrated sleep promoting effects of oral progesterone replacement in postmenopausal women. The oral administration of progesterone, however, is compromised by individual differences in bioavailability and metabolism of the steroid. OBJECTIVE: We compared the sleep-endocrine effects after intranasal progesterone (MPP22), zolpidem and placebo in healthy postmenopausal women...
April 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29621412/association-of-the-melatonin-circadian-rhythms-with-clock-3111t-c-gene-polymorphism-in-caucasian-and-asian-menopausal-women-with-insomnia
#4
Natalya V Semenova, Irina M Madaeva, Tatiana A Bairova, Radzhana M Zhambalova, Leonid F Sholokhov, Luybov I Kolesnikova
A comparative analysis of melatonin circadian rhythms in Caucasian (incoming population) and Asian (indigenous population) menopausal women with/without sleep disorders depending on the genotype of Clock 3111T/C gene polymorphism was realized.The melatonin level in the saliva was determined four times a day (6:00-7:00, 12:00-13:00, 18:00-19:00, 23:00-00:00 h). The Caucasian women-carriers of the TT-genotype with insomnia as compared to control group-had a higher morning melatonin level and a lower night melatonin level...
April 5, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29619605/both-melatonin-and-meloxicam-improved-sleep-and-pain-in-females-with-primary-dysmenorrhea-results-from-a-double-blind-cross-over-intervention-pilot-study
#5
Farahnaz Keshavarzi, Fariba Mahmoudzadeh, Serge Brand, Dena Sadeghi Bahmani, Fariba Akbari, Habibolah Khazaie, Mohammad Rasoul Ghadami
Up to 25% of ovulating women suffer from primary dysmenorrhea, a condition associated with pain and transient-reduced quality of life, along with greater irritability and impaired sleep. In the present study, we asked whether and if so to what extent melatonin and meloxicam can improve subjective and objective sleep and reduce pain among women with primary dysmenorrhea (PD). To this end, we conducted a double-blind cross-over clinical trial lasting for three menstrual cycles. A total of 14 women (mean age M = 27...
April 4, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29609867/circadian-health-differs-between-boys-and-girls-as-assessed-by-non-invasive-tools-in-school-aged-children
#6
Gloria Maria Barraco, Nuria Martínez-Lozano, Claudia Vales-Villamarín, María Del Carmen Blaya, Rafael Rios, Juan Antonio Madrid, Paul Fardy, Marta Garaulet
BACKGROUND & AIMS: Assessment of circadian health is confined to adults. However, understanding circadian status of school-aged children is necessary due to its health implications. The aim was to develop 1) a protocol to assess circadian function in school-aged children by combining the best non-invasive tools previously validated in adults; 2) a score to capture circadian function in children including food timing. This protocol will allow to explore gender differences and to compare the circadian function of school-aged children with adults from the same Mediterranean area...
March 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29609711/melatonin-responsive-complex-nocturnal-visual-hallucinations
#7
Liudmila Lysenko, Sushanth Bhat
Complex nocturnal visual hallucinations are vivid, dramatic, intricate visual hallucinations occurring during sleep onset or awakenings at night, generally lasting for a few minutes at most and disappearing with increased levels of light. They may occur in a number of neurological conditions, as well as in normal individuals. The optimal treatment for this condition remains unclear. We describe three patients with complex nocturnal visual hallucinations in whom melatonin brought about a dramatic improvement in symptoms...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29609703/diagnostic-and-treatment-challenges-of-sighted-non-24-hour-sleep-wake-disorder
#8
Roneil G Malkani, Sabra M Abbott, Kathryn J Reid, Phyllis C Zee
STUDY OBJECTIVES: To report the diagnostic and treatment challenges of sighted non-24-hour sleep-wake disorder (N24SWD). METHODS: We report a series of seven sighted patients with N24SWD clinically evaluated by history and sleep diaries, and when available wrist actigraphy and salivary melatonin levels, and treated with timed melatonin and bright light therapy. RESULTS: Most patients had a history of a delayed sleep-wake pattern prior to developing N24SWD...
March 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29607220/remember-the-drive-home-an-assessment-of-emergency-providers-sleep-deficit
#9
Brian A Ferguson, Hugh W Shoff, Jennifer E McGowan, Martin R Huecker
Objective: Sleep deprivation decreases work performance and predisposes workers to deleterious health outcomes. We sought to evaluate sleep hygiene and fatigue among emergency physicians. Methods: In March-June 2016, physicians and residents at an academic emergency medicine program were invited to complete a survey evaluating sleep and alertness. Results: Six attending physicians and 26 residents completed the survey. Among six personal priorities, sleep ranked fourth behind family, work, and leisure...
2018: Emergency Medicine International
https://www.readbyqxmd.com/read/29590381/the-circadian-rhythm-related-mtnr1b-genotype-gestational-weight-gain-and-postpartum-glycemic-changes
#10
Hoirun Nisa, Kevin H T Qi, Junhong Leng, Tao Zhou, Huikun Liu, Weiqin Li, Leishen Wang, Nan Li, Gang Hu, Lu Qi
Context: Disturbed circadian rhythms and sleep quality during pregnancy have been related to gestational weight gain and gestational diabetes mellitus (GDM), which affect postpartum glucose metabolism and future risk of type 2 diabetes. Objective: We assessed whether the circadian rhythm-related melatonin receptor 1B (MTNR1B) genotype was associated with 1-5 years of postpartum glycemic changes among women with a history of GDM; and whether gestational weight gain modified such associations...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29561501/the-iprgc-driven-pupil-response-with-light-exposure-refractive-error-and-sleep
#11
Kaleb S Abbott, Hope M Queener, Lisa A Ostrin
SIGNIFICANCE: We investigated links between the intrinsically photosensitive retinal ganglion cells, light exposure, refractive error, and sleep. Results showed that morning melatonin was associated with light exposure, with modest differences in sleep quality between myopes and emmetropes. Findings suggest a complex relationship between light exposure and these physiological processes. PURPOSE: Intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with pathways to the midbrain to control pupil size and circadian rhythm...
March 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29551048/impact-of-exposure-to-dim-light-at-night-on-sleep-in-female-and-comparison-with-male-subjects
#12
Chul-Hyun Cho, Ho-Kyoung Yoon, Seung-Gul Kang, Leen Kim, Eun-Il Lee, Heon-Jeong Lee
Objective: Light pollution has become a social and health issue. We performed an experimental study to investigate impact of dim light at night (dLAN) on sleep in female subjects, with measurement of salivary melatonin. Methods: The 25 female subjects (Group A: 12; Group B: 13 subjects) underwent a nocturnal polysomnography (NPSG) session with no light (Night 1) followed by an NPSG session randomly assigned to two conditions (Group A: 5; Group B: 10 lux) during a whole night of sleep (Night 2)...
March 19, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29545088/stress-sleep-and-sex-a-review-of-endocrinological-research-inoctodon-degus
#13
REVIEW
Carolyn M Bauer, Loreto A Correa, Luis A Ebensperger, L Michael Romero
The Common Degu (Octodon degus) is a small rodent endemic to central Chile. It has become an important model for comparative vertebrate endocrinology because of several uncommon life-history features - it is diurnal, shows a high degree of sociality, practices plural breeding with multiple females sharing natal burrows, practices communal parental care, and can easily be studied in the laboratory and the field. Many studies have exploited these features to make contributions to comparative endocrinology. This review summarizes contributions in four major areas...
March 12, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29541149/coping-with-the-new-era-noise-and-light-pollution-hperactivity-and-steroid-hormones-towards-an-evolutionary-view-of-bipolar-disorders
#14
REVIEW
M G Carta, A Preti, H S Akiskal
Human population is increasing in immense cities with millions of inhabitants, in which life is expected to run 24 hours a day for seven days a week (24/7). Noise and light pollution are the most reported consequences, with a profound impact on sleep patterns and circadian biorhythms. Disruption of sleep and biorhythms has severe consequences on many metabolic pathways. Suppression of melatonin incretion at night and the subsequent effect on DNA methylation may increase the risk of prostate and breast cancer...
2018: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29528974/changes-in-morning-salivary-melatonin-correlate-with-prefrontal-responses-during-working-memory-performance
#15
William D S Killgore, Haley C Kent, Sara A Knight, Anna Alkozei
Humans demonstrate a circadian rhythm of melatonin production that closely tracks the daily light/dark cycle, with profound increases in circulating levels during the night-time and nearly nonexistent levels during daylight hours. Although melatonin is known to play a role in preparing the brain and body for sleep, its effects on cognition and brain function are not well understood. We hypothesized that declines in morning melatonin would be associated with increased functional activation within cortical regions involved in alertness, attention, and executive function...
March 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29516556/free-running-circadian-period-in-adolescents-and-adults
#16
Stephanie J Crowley, Charmane I Eastman
Sleep timing shifts later during adolescence (second decade). This trend reverses at ~20 years and continues to shift earlier into adulthood. The current analysis examined the hypothesis that a longer free-running circadian period during late adolescence (14-17 years) compared with adulthood (30-45 years) accounts for sleep timing differences. Sex and ancestry were also examined because previous reports find that women and those with African-American ancestry have shorter free-running periods. Circadian period was measured using an ultradian dark-light protocol (2 hr dark/sleep, 2 hr dim room light [~20 lux]/wake) over 3...
March 8, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29516223/a-circadian-rhythm-related-mtnr1b-genetic-variant-modulates-the-effect-of-weight-loss-diets-on-changes-in-adiposity-and-body-composition-the-pounds-lost-trial
#17
Leticia Goni, Dianjianyi Sun, Yoriko Heianza, Tiange Wang, Tao Huang, J Alfredo Martínez, Xiaoyun Shang, George A Bray, Steven R Smith, Frank M Sacks, Lu Qi
PURPOSE: A common variant of the melatonin receptor 1B (MTNR1B) gene has been related to increased signaling of melatonin, a hormone previously associated with body fatness mainly through effects on energy metabolism. We examined whether the MTNR1B variant affects changes of body fatness and composition in response to a dietary weight loss intervention. METHODS: The MTNR1B rs10830963 variant was genotyped for 722 overweight and obese individuals, who were randomly assigned to one of four diets varying in macronutrient composition...
March 7, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29510794/daytime-sleep-disturbance-in-night-shift-work-and-the-role-of-period3
#18
Philip Cheng, Gabriel Tallent, Helen J Burgess, Kieulinh Michelle Tran, Thomas Roth, Christopher L Drake
STUDY OBJECTIVES: Recent evidence indicates that daytime sleep disturbance associated with night shift work may arise from both circadian misalignment and sleep reactivity to stress. This presents an important clinical challenge because there are limited means of predicting and distinguishing between the two mechanisms, and the respective treatments differ categorically; however, there is support that a polymorphism in the PERIOD3 gene ( PER3 ) may indicate differences in vulnerability to daytime sleep disturbance in shift workers...
February 27, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29504270/sensitivity-of-the-circadian-system-to-evening-bright-light-in-preschool-age-children
#19
Lameese D Akacem, Kenneth P Wright, Monique K LeBourgeois
Although the light-induced melatonin suppression response is well characterized in adults, studies examining the dynamics of this effect in children are scarce. The purpose of this study was to quantify the magnitude of evening light-induced melatonin suppression in preschool-age children. Healthy children (n = 10; 7 females; 4.3 ± 1.1 years) participated in a 7-day protocol. On days 1-5, children followed a strict sleep schedule. On day 6, children entered a dim light environment (<15 lux) for 1-h before providing salivary samples every 20- to 30-min from the afternoon until 50-min after scheduled bedtime...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29498667/long-term-melatonin-therapy-for-adolescents-and-young-adults-with-chronic-sleep-onset-insomnia-and-late-melatonin-onset-evaluation-of-sleep-quality-chronotype-and-lifestyle-factors-compared-to-age-related-randomly-selected-population-cohorts
#20
Tom C Zwart, Marcel G Smits, Toine C G Egberts, Carin M A Rademaker, Ingeborg M van Geijlswijk
The extent of continuance of melatonin therapy initiated in pre-pubertal children with chronic sleep onset insomnia (CSOI) was investigated in young adult life. Sleep timing, sleep quality, adverse events, reasons for cessation of therapy, and patient characteristics with regard to therapy regimen, chronotype and lifestyle factors possibly influencing sleeping behavior were assessed. With an online survey using questionnaires (Pittsburgh Sleep Quality Index, Insomnia Severity Index, Morningness-Eveningness Questionnaire, and Munich Chronotype Questionnaire), outcomes were measured and compared with age-related controls...
March 2, 2018: Healthcare (Basel, Switzerland)
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