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Melatonin sleep

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https://www.readbyqxmd.com/read/28530143/intranasal-melatonin-nanoniosomes-pharmacokinetic-pharmacodynamics-and-toxicity-studies
#1
Aroonsri Priprem, Jeffrey R Johns, Sucharat Limsitthichaikoon, Wanwisa Limphirat, Pramote Mahakunakorn, Nutjaree Prateepawanit Johns
AIM: Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated. METHODOLOGY: A formula of melatonin niosomes (MN) was selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics and toxicity studies in male Wistar rats. RESULTS: Intranasal MN was bioequivalent to intravenous injection of melatonin, providing therapeutic level doses. Acute and subchronic toxicity screening showed no abnormal signs, symptoms or hematological effects in any animals...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28526480/human-seasonal-and-circadian-studies-in-antarctica-halley-75-0-s
#2
Josephine Arendt, Benita Middleton
Living for extended periods in Antarctica exposes base personnel to extremes of daylength (photoperiod) and temperature. At the British Antarctic Survey base of Halley, 75(0)S, the sun does not rise for 110 d in the winter and does not set for 100 d in summer. Photoperiod is the major time cue governing the timing of seasonal events such as reproduction in many species. The neuroendocrine signal providing photoperiodic information to body physiology is the duration of melatonin secretion which reflects the length of the night: longer in the short days of winter and shorter in summer...
May 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28522096/sleep-and-circadian-variability-in-people-with-delayed-sleep-wake-phase-disorder-versus-healthy-controls
#3
Helen J Burgess, Margaret Park, James K Wyatt, Muneer Rizvydeen, Louis F Fogg
OBJECTIVE/BACKGROUND: To compare sleep and circadian variability in adults with delayed sleep-wake phase disorder (DSWPD) to healthy controls. PATIENTS/METHODS: Forty participants (22 DSWPD, 18 healthy controls) completed a ten-day protocol, consisting of DLMO assessments on two consecutive nights, a five-day study break, followed by two more DLMO assessments. All participants were instructed to sleep within one hour of their self-reported average sleep schedule for the last four days of the study break...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28522084/circadian-phase-dynamics-of-subjective-sleepiness-and-sensitivity-to-blue-light-in-young-adults-complaining-of-a-delayed-sleep-schedule
#4
Christophe Moderie, Solenne Van der Maren, Marie Dumont
OBJECTIVE: To assess factors that might contribute to a delayed sleep schedule in young adults with sub-clinical features of delayed sleep phase disorder. METHODS: Two groups of 14 young adults (eight women) were compared: one group complaining of a delayed sleep schedule and a control group with an earlier bedtime and no complaint. For one week, each subject maintained a target bedtime reflecting their habitual sleep schedule. Subjects were then admitted to the laboratory for the assessment of circadian phase (dim light melatonin onset), subjective sleepiness, and non-visual light sensitivity...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28513079/rem-sleep-behavior-disorder-in-parkinson-s-disease-and-other-synucleinopathies
#5
REVIEW
Erik K St Louis, Angelica R Boeve, Bradley F Boeve
Rapid eye movement sleep behavior disorder is characterized by dream enactment and complex motor behaviors during rapid eye movement sleep and rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia) during polysomnography. Rapid eye movement sleep behavior disorder may be idiopathic or symptomatic and in both settings is highly associated with synucleinopathy neurodegeneration, especially Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure...
May 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28507521/prime-time-light-exposures-do-not-seem-to-improve-maximal-physical-performance-in-male-elite-athletes-but-enhance-end-spurt-performance
#6
Raphael Knaier, Juliane Schäfer, Anja Rossmeissl, Christopher Klenk, Henner Hanssen, Christoph Höchsmann, Christian Cajochen, Arno Schmidt-Trucksäss
Many sports competitions take place during television prime time, a time of the day when many athletes have already exceeded their time of peak performance. We assessed the effect of different light exposure modalities on physical performance and melatonin levels in athletes during prime time. Seventy-two young, male elite athletes with a median (interquartile range) age of 23 (21; 29) years and maximum oxygen uptake (VO2max) of 63 (58; 66) ml/kg/min were randomly assigned to three different light exposure groups: bright light (BRIGHT), blue monochromatic light (BLUE), and control light (CONTROL)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28502070/sleep-in-children-with-autism-spectrum-disorder
#7
REVIEW
Margaret C Souders, Stefanie Zavodny, Whitney Eriksen, Rebecca Sinko, James Connell, Connor Kerns, Roseann Schaaf, Jennifer Pinto-Martin
The purposes of this paper are to provide an overview of the state of the science of sleep in children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of insomnia in children with ASD, and present a practice pathway for promoting optimal sleep. Approximately two thirds of children with ASD have chronic insomnia, and to date, the strongest evidence on promoting sleep is for sleep education, environmental changes, behavioral interventions, and exogenous melatonin. The Sleep Committee of the Autism Treatment Network (ATN) developed a practice pathway, based on expert consensus, to capture best practices for screening, identification, and treatment for sleep problems in ASD in 2012...
June 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28494914/the-effect-of-melatonin-on-early-postoperative-cognitive-decline-in-elderly-patients-undergoing-hip-arthroplasty-a-randomized-controlled-trial
#8
Yunxia Fan, Liang Yuan, Muhuo Ji, Jianjun Yang, Dapeng Gao
STUDY OBJECTIVE: The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia. DESIGN: Prospective cohort study. SETTING: Department of Anesthesiology, Jinling Hospital, Nanjing University, Nanjing, China. PATIENTS: One hundred and thirty-nine patients with ASA I-III, older than 65yr of age (mean age: 74...
June 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28488901/association-of-shiftwork-and-immune-cells-among-police-officers-from-the-buffalo-cardio-metabolic-occupational-police-stress-study
#9
Michael D Wirth, Michael E Andrew, Cecil M Burchfiel, James B Burch, Desta Fekedulegn, Tara A Hartley, Luenda E Charles, John M Violanti
Shift workers suffer from a constellation of symptoms associated with disruption of circadian rhythms including sleep abnormalities, and abnormal hormone secretion (e.g. melatonin, cortisol). Recent, but limited, evidence suggests that shift workers have elevated levels of circulating white blood cells (WBCs) compared to their day working counterparts. Interestingly, recent reviews highlight the strong linkage between the immune system and circadian rhythms which includes, but is not limited to, circulating cell populations and functions...
May 10, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28487255/disruption-of-adolescents-circadian-clock-the-vicious-circle-of-media-use-exposure-to-light-at-night-sleep-loss-and-risk-behaviors
#10
Yvan Touitou, David Touitou, Alain Reinberg
Although sleep is a key element in adolescent development, teens are spending increasing amounts of time online with health risks related to excessive use of electronic media (computers, smartphones, tablets, consoles…) negatively associated with daytime functioning and sleep outcomes. Adolescent sleep becomes irregular, shortened and delayed in relation with later sleep onset and early waking time due to early school starting times on weekdays which results in rhythm desynchronization and sleep loss. In addition, exposure of adolescents to the numerous electronic devices prior to bedtime has become a great concern because LEDs emit much more blue light than white incandescent bulbs and compact fluorescent bulbs and have therefore a greater impact on the biological clock...
May 6, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28486925/the-mutual-interaction-between-sleep-and-epilepsy-on-the-neurobiological-basis-and-therapy
#11
Yi-Qun Wang, Meng-Qi Zhang, Rui Li, Wei-Min Qu, Zhi-Li Huang
Sleep and epilepsy are mutually related in a complex, bidirectional manner. However, our understanding of this relationship remains unclear. In this paper, we address the issues involved in these phenomena and also discuss the various therapies used to modify them. The literatures of the neurobiological basis of the interactions between sleep and epilepsy indicate that non-rapid eye movement sleep and idiopathic generalized epilepsy share the same thalamocortical networks. Neuromodulators-such as adenosine, melatonin, prostaglandin D2, serotonin, and histamine-promote wakefulness and are considered to have antiepilepsy effects; antiepileptic drugs, in turn, also have effects on sleep...
May 8, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28479928/cardioprotective-effects-of-huoxueanshen-recipe-against-myocardial-injuries-induced-by-sleep-deprivation-in-rats
#12
Rong Yuan, Li-Li Guo, Heng-Wen Chen, Jun-Ping Li, Zhong Chen, Ben-Jun Wei, Jie Wang
Background. Traditional Chinese Medicine is extensively used in China and HuoxueAnshen Recipe (HAR) was formulated according to its method in treating CHD accompanied with insomnia in clinic. However, there are few studies related to the effect of HAR on myocardial injury and sleep disorders. Purpose. To investigate the effects of HAR on sleep deprivation- (SD-) induced myocardial I/R injury. Methods. Male Wistar rats receiving a daily gavage of HAR or vehicle were exposed to SD intervention while control rats had normal sleep...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28472667/the-effects-of-spectral-tuning-of-evening-ambient-light-on-melatonin-suppression-alertness-and-sleep
#13
Shadab A Rahman, Melissa A St Hilaire, Steven W Lockley
We compared the effects of bedroom-intensity light from a standard fluorescent and a blue- (i.e., short-wavelength) depleted LED source on melatonin suppression, alertness, and sleep. Sixteen healthy participants (8 females) completed a 4-day inpatient study. Participants were exposed to blue-depleted circadian-sensitive (C-LED) light and a standard fluorescent light (FL, 4100K) of equal illuminance (50lx) for 8h prior to a fixed bedtime on two separate days in a within-subject, randomized, cross-over design...
May 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28470121/shift-work-and-cognitive-flexibility-decomposing-task-performance
#14
Philip Cheng, Gabriel Tallent, Thomas John Bender, Kieulinh Michelle Tran, Christopher L Drake
Deficits in cognitive functioning associated with shift work are particularly relevant to occupational performance; however, few studies have examined how cognitive functioning is associated with specific components of shift work. This observational study examined how circadian phase, nocturnal sleepiness, and daytime insomnia in a sample of shift workers ( N = 30) were associated with cognitive flexibility during the night shift. Cognitive flexibility was measured using a computerized task-switching paradigm, which produces 2 indexes of flexibility: switch cost and set inhibition...
April 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28463346/an-algorithmic-approach-to-the-management-of-insomnia-in-patients-with-schizophrenia
#15
Ridha Joober, Katherine Cole, Karim Tabbane, Diane B Boivin
BACKGROUND: Insomnia is an important problem in patients with schizophrenia and is an emerging area of interest for researchers. We propose a treatment algorithm that synthesizes the various psychological and pharmacological interventions for insomnia in this population. METHODS: Our selective literature review incorporates English language articles from 4 medicine databases through May 2016. Selected articles discuss risk factors and treatments for insomnia, as well as comorbid sleep disorders that coexist in this population...
May 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28460563/a-review-of-sleep-disorders-and-melatonin
#16
Zizhen Xie, Fei Chen, William A Li, Xiaokun Geng, Changhong Li, Xiaomei Meng, Yan Feng, Wei Liu, Fengchun Yu
Sleep disorders are a group of conditions that affect the ability to sleep well on a regular basis and cause significant impairments in social and occupational functions. Although currently approved medications are efficacious, they are far from satisfactory. Benzodiazepines, antidepressants, antihistamines and anxiolytics have the potential for dependence and addiction. Moreover, some of these medications can gradually impair cognition. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous hormone produced by the pineal gland and released exclusively at night...
June 2017: Neurological Research
https://www.readbyqxmd.com/read/28460319/altered-mt1-and-mt2-melatonin-receptors-expression-in-the-hippocampus-of-pilocarpine-induced-epileptic-rats
#17
Anna Karynna Alves de Alencar Rocha, Eliangela de Lima, Fernanda Amaral, Rafael Peres, José Cipolla-Neto, Débora Amado
Clinical and experimental findings show that melatonin may be used as an adjuvant to the treatment of epilepsy-related complications by alleviates sleep disturbances, circadian alterations and attenuates seizures alone or in combination with AEDs. In addition, it has been observed that there is a circadian component on seizures, which cause changes in circadian system and in melatonin production. Nevertheless, the dynamic changes of the melatoninergic system, especially with regard to its membrane receptors (MT1 and MT2) in the natural course of TLE remain largely unknown...
April 28, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28456823/a-systematic-review-of-interventions-to-deprescribe-benzodiazepines-and-other-hypnotics-among-older-people
#18
REVIEW
Emily Reeve, Magdalene Ong, Angela Wu, Jesse Jansen, Mirko Petrovic, Danijela Gnjidic
PURPOSE: Benzodiazepines are effective medicines for insomnia and anxiety but are commonly used beyond recommended treatment time frames, which may lead to adverse drug events. The aim of this systematic review was to critically evaluate the success of interventions used to reduce benzodiazepines and 'Z-drug' use, and the impact of these interventions on clinical outcomes in older adults. METHODS: A search was conducted in PubMed, Embase, Informit, International Pharmaceutical Abstracts, Scopus, PsychINFO, Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL...
April 30, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28455107/sleep-quality-and-duration-in-relation-to-memory-in-the-elderly-initial-results-from-the-hellenic-longitudinal-investigation-of-aging-and-diet
#19
A Tsapanou, Y Gu, D M O'Shea, M Yannakoulia, M Kosmidis, E Dardiotis, G Hadjigeorgiou, P Sakka, Y Stern, N Scarmeas
BACKGROUND: Sleep is crucial for cognition, particularly for memory, given its complex association with neurodegenerative processes. The aim of the present study was to examine the association between sleep quality as well as sleep duration and memory performance in a Greek elderly population. SETTING: Cross-sectional design in the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD), a population representative study of Greek elderly (65years or older)...
April 26, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28452285/daily-light-exposure-patterns-reveal-phase-and-period-of-the-human-circadian-clock
#20
Tom Woelders, Domien G M Beersma, Marijke C M Gordijn, Roelof A Hut, Emma J Wams
Light is the most potent time cue that synchronizes (entrains) the circadian pacemaker to the 24-h solar cycle. This entrainment process is an interplay between an individual's daily light perception and intrinsic pacemaker period under free-running conditions. Establishing individual estimates of circadian phase and period can be time-consuming. We show that circadian phase can be accurately predicted (SD = 1.1 h for dim light melatonin onset, DLMO) using 9 days of ambulatory light and activity data as an input to Kronauer's limit-cycle model for the human circadian system...
April 1, 2017: Journal of Biological Rhythms
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