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https://www.readbyqxmd.com/read/29928535/field-study-of-effects-of-night-shifts-on-cognitive-performance-salivary-melatonin-and-sleep
#1
Reza Kazemi, Majid Motamedzade, Rostam Golmohammadi, Hamidreza Mokarami, Rasoul Hemmatjo, Rashid Heidarimoghadam
Background: Night shift work is associated with many problems such as sleep deprivation, sleepiness, decreased cognitive performance, increased human errors, and fatigue. This study set out to measure cognitive performance, melatonin rhythms, and sleep after different consecutive night shifts (7 vs. 4) among control room operators (CORs). Methods: The participants included 60 CORs with a mean age of 30.2 years (standard deviation, 2.0) from a petrochemical complex located in Southern Iran...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29914382/a-systematic-review-of-non-pharmacological-interventions-to-improve-nighttime-sleep-among-residents-of-long-term-care-settings
#2
Elizabeth Capezuti, Rana Sagha Zadeh, Kevin Pain, Aleksa Basara, Nancy Ziyan Jiang, Ana C Krieger
BACKGROUND: Disturbances in sleep and circadian rhythms are common among residents of long-term care facilities. In this systematic review, we aim to identify and evaluate the literature documenting the outcomes associated with non-pharmacological interventions to improve nighttime sleep among long-term care residents. METHODS: The Preferred Reporting Items for Systematic Reviews guided searches of five databases (MEDLINE, Embase, CINAHL, Scopus, and Cochrane Library) for articles reporting results of experimental or quasi-experimental studies conducted in long-term care settings (nursing homes, assisted-living facilities, or group homes) in which nighttime sleep was subjectively or objectively measured as a primary outcome...
June 18, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29912983/efficacy-of-melatonin-with-behavioural-sleep-wake-scheduling-for-delayed-sleep-wake-phase-disorder-a-double-blind-randomised-clinical-trial
#3
Tracey L Sletten, Michelle Magee, Jade M Murray, Christopher J Gordon, Nicole Lovato, David J Kennaway, Stella M Gwini, Delwyn J Bartlett, Steven W Lockley, Leon C Lack, Ronald R Grunstein, Shantha M W Rajaratnam
BACKGROUND: Delayed Sleep-Wake Phase Disorder (DSWPD) is characterised by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at the required time for daytime commitments. Although there are published therapeutic guidelines for the administration of melatonin for DSWPD, to our knowledge, randomised controlled trials are lacking. This trial tested the efficacy of 0.5 mg melatonin, combined with behavioural sleep-wake scheduling, for improving sleep initiation in clinically diagnosed DSWPD patients with a delayed endogenous melatonin rhythm relative to patient-desired (or -required) bedtime (DBT)...
June 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29908879/exogenous-melatonin-as-a-treatment-for-secondary-sleep-disorders-a-systematic-review-and-meta-analysis
#4
REVIEW
Tian Li, Shuai Jiang, Mengzhen Han, Zhi Yang, Jianjun Lv, Chao Deng, Russel J Reiter, Yang Yang
Melatonin is a physiological indoleamine involved in circadian rhythm regulation and it is currently used for secondary sleep disorders supported by empirical evidence. A small amount of evidence and some controversial results have been obtained in some randomized controlled trials (RCT). The objective of this meta-analysis is to determine the efficacy of exogenous melatonin versus placebo in managing secondary sleep disorders. Literature retrieval of eligible RCT was performed in 5 databases (PubMed, Embase, Cochrane Library, ClinicalTrials...
June 14, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29907085/long-term-persistence-of-withdrawal-of-temazepam-zopiclone-and-zolpidem-in-older-adults-a-3-year-follow-up-study
#5
Juha Puustinen, Ritva Lähteenmäki, Janne Nurminen, Tero Vahlberg, Pertti Aarnio, Markku Partinen, Ismo Räihä, Pertti J Neuvonen, Sirkka-Liisa Kivelä
BACKGROUND: Studies on persistence of benzodiazepine agonist (BZDA) withdrawal in older outpatients are few, and few studies on long-term persistence over years have yet been published. To describe the persistence of temazepam, zolpidem, and zopiclone (BZDA) withdrawal among older outpatients at 3 years from the beginning of withdrawal, as well as any changes in use of other medications. METHODS: 92 outpatients (≥55 years) with primary insomnia, long-term BZDA use as hypnotics (mean duration of BZDA use 9...
June 15, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29902071/anti-inflammatory-effects-of-melatonin-a-mechanistic-review
#6
Seyed Mohammad Nabavi, Seyed Fazel Nabavi, Antoni Sureda, Janbo Xiao, Ahmad Reza Dehpour, Samira Shirooie, Ana Sanches Silva, Alessandra Baldi, Haroon Khan, Maria Daglia
N-acetyl-5-methoxy-tryptamine (melatonin) is a natural substance produced both by plants, as a secondary metabolite, and animals, by the pineal gland and other tissues. In humans, melatonin participates in numerous functions including the regulation of mood, sleep, reproduction, promotion of immunomodulation, antioxidant defense and as an anti-inflammatory agent. The anti-inflammatory activity of melatonin could yield beneficial effects on intake, particularly against the chronic inflammation which underlies many chronic diseases...
June 14, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29898451/pathophysiology-of-depression-molecular-regulation-of-melatonin-homeostasis-current-status
#7
REVIEW
Monika Dmitrzak-Weglarz, Edyta Reszka
Circadian rhythm alterations resulting in disturbed sleep and disturbed melatonin secretion are flagship features of depression. Melatonin, known as a hormone of darkness, is secreted by the pineal gland located near to the center of the brain between the two hemispheres. Melatonin has an antidepressant effect by maintaining the body's circadian rhythm, by regulating the pattern of expression of the clock genes in the suprachiasmatic nucleus (SCN) and modifying the key genes of serotoninergic neurotransmission that are linked with a depressive mood...
June 13, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29881321/pharmacotherapy-of-insomnia
#8
REVIEW
David N Neubauer, Seithikurippu R Pandi-Perumal, David Warren Spence, Kenneth Buttoo, Jaime M Monti
Insomnia remains a common clinical concern that is associated with negative daytime consequences for patients and represents a significant public health problem for our society. Although a variety of therapies may be employed to treat insomnia, the use of medications has been a dominant approach. Regulatory agencies have now classified insomnia medications into 4 distinct pharmacodynamics classes. Medications with indications approved for insomnia treatment include benzodiazepine receptor agonists, a melatonin receptor agonist, a selective histamine receptor antagonist, and a dual orexin/hypocretin receptor antagonist...
2018: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/29869403/circadian-rhythm-in-bipolar-disorder-a-review-of-the-literature
#9
REVIEW
Yoshikazu Takaesu
Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in patients with bipolar disorder (BD). Irregularity of the sleep-wake rhythm, eveningness chronotype, abnormality of melatonin secretion, vulnerability of clock genes, and the irregularity of social time cues have also been well-documented in BD. Circadian rhythm dysfunction is prominent in BD compared with that in major depressive disorders, implying that circadian rhythm dysfunction is a trait marker of BD. In the clinical course of BD, the circadian rhythm dysfunctions may act as predictors for the first onset of BD and the relapse of mood episodes...
June 5, 2018: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29869076/therapeutic-symptomatic-strategies-in-the-parasomnias
#10
REVIEW
Raffaele Manni, Gianpaolo Toscano, Michele Terzaghi
PURPOSE OF REVIEW: The purpose of this review was to discuss the currently available pharmacologic and non-pharmacologic treatment options for parasomnias. RECENT FINDINGS: Recent pathophysiological findings about sleep structure in parasomnias helped understanding several drug mechanisms of action. Serotoninergic theory accounts for the effect of serotoninergic drugs. Study about spectral analysis of sleep showed the effect of clonazepam on spectral bands. Cannabinoids proved to be effective in some of parasomnias, as in many other neurological disorders...
June 5, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29867569/cardiovascular-benefits-of-dietary-melatonin-a-myth-or-a-reality
#11
REVIEW
Zukiswa Jiki, Sandrine Lecour, Frederic Nduhirabandi
The role of the diet as well as the impact of the dietary habits on human health and disease is well established. Apart from its sleep regulatory effect, the indoleamine melatonin is a well-established antioxidant molecule with multiple health benefits. Convincing evidence supports the presence of melatonin in plants and foods with the intake of such foods affecting circulating melatonin levels in humans. While numerous actions of both endogenous melatonin and melatonin supplementation are well described, little is known about the influence of the dietary melatonin intake on human health...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29860260/twenty-years-after-another-case-report-of-melatonin-effects-on-rem-sleep-behavior-disorder-using-serial-dopamine-transporter-imaging
#12
Dieter Kunz, Frederik Bes
INTRODUCTION: REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated with melatonin. CASE PRESENTATION: A then 72-year-old man was clinically suspected to suffer from PD in 2011. DA transporter scintigraphy (DaTSCAN) revealed reduced DA transporter density, and the patient was diagnosed with developing PD...
June 1, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29846091/melatonin-ingestion-after-exhaustive-late-evening-exercise-improves-sleep-quality-and-quantity-and-short-term-performances-in-teenage-athletes
#13
Mohamed Cheikh, Omar Hammouda, Nawel Gaamouri, Tarak Driss, Karim Chamari, Ridha Ben Cheikh, Mohamed Dogui, Nizar Souissi
The present study aimed to explore the effects of a single 10-mg dose of melatonin (MEL) administration after exhaustive late-evening exercise on sleep quality and quantity, and short-term physical and cognitive performances in healthy teenagers. Ten male adolescent athletes (mean ± SD, age = 15.4 ± 0.3 years, body-mass = 60.68 ± 5.7 kg, height = 167.9 ± 6.9 cm and BMI = 21.21 ± 2.5) performed two test sessions separated by at least one week. During each session, participants completed the Yo-Yo intermittent-recovery-test level-1 (YYIRT-1) at ~20:00 h...
May 30, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29845764/unrestricted-evening-use-of-light-emitting-tablet-computers-delays-self-selected-bedtime-and-disrupts-circadian-timing-and-alertness
#14
Evan D Chinoy, Jeanne F Duffy, Charles A Czeisler
Consumer electronic devices play an important role in modern society. Technological advancements continually improve their utility and portability, making possible the near-constant use of electronic devices during waking hours. For most people, this includes the evening hours close to bedtime. Evening exposure to light-emitting (LE) devices can adversely affect circadian timing, sleep, and alertness, even when participants maintain a fixed 8-hour sleep episode in darkness and the duration of evening LE-device exposure is limited...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29797213/evaluation-of-melatonin-and-afmk-levels-in-women-with-breast-cancer
#15
Tialfi Bergamin de Castro, Newton Antônio Bordin-Junior, Eduardo Alves de Almeida, Debora Aparecida Pires de Campos Zuccari
PURPOSE: Changes in the circadian rhythm may contribute to the development of cancer and are correlated with the high risk of breast cancer (BC) in night workers. Melatonin is a hormone synthesized by the pineal gland at night in the absence of light. Levels of melatonin and the metabolite of oxidative metabolism AFMK (acetyl-N-formyl-5-methoxykynurenamine), are suggested as potential biomarkers of BC risk. The aims of this study were to evaluate levels of melatonin and AFMK in women recently diagnosed with BC, women under adjuvant chemotherapy, and night-shift nurses, and compare them with healthy women to evaluate the relation of these compounds with BC risk...
May 24, 2018: Endocrine
https://www.readbyqxmd.com/read/29796038/effect-of-melatonin-administration-on-sleep-quality-in-sulfur-mustard-exposed-patients-with-sleep-disorders
#16
Seyyedeh Soghra Mousavi, Majid Shohrati, Ensieh Vahedi, Meghdad Abdollahpour-Alitappeh, Yunes Panahi
Sulfur mustard (SM) is a toxic agent that targets several tissues. It is the leading cause of persistent lung disease, progressive deterioration in lung function, and mortality among injured patients. Disturbed sleep and poor quality of sleep are common in SM-exposed patients with chronic respiratory problems. Melatonin is an alternative medication that has been widely used to treat poor sleep quality caused by several specific conditions. This study aimed to evaluate the efficacy of melatonin administration in improvement of sleep quality in SM-injured patients...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29787851/jetlag-related-sleep-problems-and-its-management-a-review
#17
REVIEW
Cemal Cingi, Ismet Emrah Emre, Nuray Bayar Muluk
OBJECTIVES: We reviewed Jetlag, particularly in view of its effects on sleep and how it can be managed. METHODS: The Proquest Central database of Kırıkkale University, PubMed and Google scholar were used while searching for the following key words: "Jetlag", "symptoms", "sleep", "melatonin" and "treatment". RESULTS: Flight dysrhythmia, otherwise known as jetlag, is caused by flying globally over various time zones...
May 19, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29784788/mistimed-food-intake-and-sleep-alters-24-hour-time-of-day-patterns-of-the-human-plasma-proteome
#18
Christopher M Depner, Edward L Melanson, Andrew W McHill, Kenneth P Wright
Proteomics holds great promise for understanding human physiology, developing health biomarkers, and precision medicine. However, how much the plasma proteome varies with time of day and is regulated by the master circadian suprachiasmatic nucleus brain clock, assessed here by the melatonin rhythm, is largely unknown. Here, we assessed 24-h time-of-day patterns of human plasma proteins in six healthy men during daytime food intake and nighttime sleep in phase with the endogenous circadian clock (i.e., circadian alignment) versus daytime sleep and nighttime food intake out of phase with the endogenous circadian clock (i...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29761771/-melatonin-for-children-with-insomnia
#19
Amalie Berring-Uldum, Nanette Marinette Monique Debes, Charlotte Reinhardt Pedersen, Helle Holst
Treatment for insomnia with melatonin (MT) in children and adolescents aged 0-17 years has doubled since 2011. The efficacy and safety profile for MT in children has not been determined. Recent clinical trials indicate, that MT only has a clinical effect on sleep latency, not on total sleep time. Furthermore, it has emerged, that proper sleep hygiene can cure the sleep problem in 50% of the children. Typically, the safety evaluation only entails an unclassified report of adverse events. Two long-term studies investigate and dispel the potential influence of MT on puberty...
May 7, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29759891/the-putative-role-of-oxidative-stress-and-inflammation-in-the-pathophysiology-of-sleep-dysfunction-across-neuropsychiatric-disorders-focus-on-chronic-fatigue-syndrome-bipolar-disorder-and-multiple-sclerosis
#20
REVIEW
Gerwyn Morris, Brendon Stubbs, Cristiano A Köhler, Ken Walder, Anastasiya Slyepchenko, Michael Berk, André F Carvalho
Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders...
April 4, 2018: Sleep Medicine Reviews
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