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https://www.readbyqxmd.com/read/28426389/melatonin-and-circadian-rhythms-in-autism-case-report
#1
Gabriela Melloni Zuculo, Bruno S B Gonçalves, Clay Brittes, Luiz Menna-Barreto, Luciana Pinato
Among the most co-occurring conditions in autism spectrum disorders (ASD), there are sleep disorders which may exacerbate associated behavioral disorders and lead to intensification of existing autistic symptoms. Several studies investigating the use of melatonin in the treatment of sleep disorders in ASD have shown comparative efficiency in sleep with little or no side effects. Here we report a case of ASD with non-24-hour rhythm and the effect of melatonin in circadian parameters by actigraphy. Visual analysis of the first 10 days recorded and the periodogram suggest that this patient showed a non-24-hour rhythm...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28414966/modeling-sleep-and-neuropsychiatric-disorders-in-zebrafish
#2
REVIEW
Talia Levitas-Djerbi, Lior Appelbaum
What are the molecular and cellular mechanisms that link neurological disorders and sleep disturbances? The transparent zebrafish model could bridge this gap in knowledge due to its unique genetic and imaging toolbox, and amenability to high-throughput screening. Sleep is well-characterized in zebrafish and key regulators of the sleep/wake cycle are conserved, including melatonin and hypocretin/orexin (Hcrt), whereas novel sleep regulating proteins are continually being identified, such as Kcnh4a, Neuromedin U, and QRFP...
April 14, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28403895/electroacupuncture-for-insomnia-disorder-study-protocol-for-a-randomized-controlled-trial
#3
Sung-Phil Kim, Joo-Hee Kim, Bo-Kyung Kim, Hyeong-Jun Kim, In Chul Jung, Jung Hyo Cho, Jung-Eun Kim, Mi-Kyung Kim, O-Jin Kwon, Ae-Ran Kim, Hyo-Ju Park, Bok-Nam Seo
BACKGROUND: Insomnia is a common sleep disorder that affects many adults either transiently or chronically. The societal cost of insomnia is on the rise, while long-term use of current drug treatments can involve adverse effects. Recently, electroacupuncture (EA) has been used to treat various conditions including insomnia. The objective of this study is to provide scientific evidence for the effect and safety of using EA to treat insomnia. METHODS/DESIGN: In this multicentre, assessor-blind, three-arm, parallel-design, randomised controlled trial, 150 participants will be assigned to the EA group, the sham EA (SEA) group, or the usual care group...
April 13, 2017: Trials
https://www.readbyqxmd.com/read/28399269/loss-of-melanopsin-expressing-retinal-ganglion-cells-in-patients-with-diabetic-retinopathy
#4
Elisabeth Anne Obara, Jens Hannibal, Steffen Heegaard, Jan Fahrenkrug
Purpose: Photo-entrainment of the circadian clock is mediated by melanopsin-expressing retinal ganglion cells (mRGCs) located in the retina. Patients suffering from diabetic retinopathy (DR) show impairment of light regulated circadian activity such as sleep disorders, altered blood pressure, and abnormal melatonin secretion. The aim of this study was to assess the impact of DR on the expression of mRGCs in the human retina. Methods: The expression of mRGCs and RGCs was determined in eye sections containing retinal tissue from patients with DR (n = 6) and respective age-matched controls (n = 8) using immunohistochemistry by costaining with antibodies against RNA binding protein with multiple splicing (RBPMS), which identified RGCs and melanopsin which identified the mRGCs...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28399097/-influence-chronopharmacology-therapy-methionine-melaxen-on-the-dynamics-of-sleep-disturbance-cognitive-and-emotional-disorders-brain-derived-neurotrophic-factor-bdnf-in-patients-with-cerebral-stroke-in-the-early-and-late-recovery-periods
#5
E V Kostenko
AIM: To study the efficacy of melaxen on the dynamics of sleep disturbance, cognitive and emotional disorders, BDNF and the level of secretion of melatonin (6-SOMT) in patients with stroke in the early and late recovery phase. MATERIAL AND METHODS: One hundred and ten patients in the rehabilitation period of stroke (mean age of 58.4±6.4 years), including 60 patients in the early recovery phase (group 1) and 50 patients in the late phase (group 2), were studied...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28391425/safety-tolerability-and-efficacy-of-drugs-for-treating-behavioural-insomnia-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-review-with-methodological-quality-assessment
#6
REVIEW
Shweta Anand, Henry Tong, Frank M C Besag, Esther W Chan, Samuele Cortese, Ian C K Wong
OBJECTIVE: A large proportion of paediatric patients with attention-deficit/hyperactivity disorder (ADHD) have associated sleep problems which not only affect the child's wellbeing but also impact family functioning. Management of sleep problems is consequently an important aspect of overall ADHD management in paediatric patients. Although some drugs are being used off-label for the management of paediatric insomnia, there is scant clinical evidence supporting their use. Our aim was to identify and assess the quality of published studies reporting the safety, tolerability and efficacy of drugs used for treating behavioural insomnia in children with ADHD...
April 8, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28387721/dietary-sources-and-bioactivities-of-melatonin
#7
REVIEW
Xiao Meng, Ya Li, Sha Li, Yue Zhou, Ren-You Gan, Dong-Ping Xu, Hua-Bin Li
Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin...
April 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28382516/ramelteon-a-selective-mt1-mt2-receptor-agonist-suppresses-the-proliferation-and-invasiveness-of-endometrial-cancer-cells
#8
Kiyono Osanai, Yoichi Kobayashi, Masahiro Otsu, Tomoko Izawa, Keiji Sakai, Mitsutoshi Iwashita
The incidence of endometrial cancer is increasing, making it the fifth most common cancer worldwide. To date, however, there is no standard therapy for patients with recurrent endometrial cancer. Melatonin, a hormone secreted by the pineal gland, has been shown to have anti-tumor effects in various tumor types. Although melatonin is available as a supplement, it has not been approved for cancer treatment. Ramelteon, a selective melatonin receptor type 1 and 2 (MT1/MT2) receptor agonist, has been approved to treat sleep disorders, suggesting that ramelteon may be effective in the treatment of endometrial cancer...
April 5, 2017: Human Cell
https://www.readbyqxmd.com/read/28378363/impact-of-sleep-inertia-on-visual-selective-attention-for-rare-targets-and-the-influence-of-chronotype
#9
Hannah K Ritchie, Tina M Burke, Tristan B Dear, Andrew W Mchill, John Axelsson, Kenneth P Wright
Sleep inertia is affected by circadian phase, with worse performance upon awakening from sleep during the biological night than biological day. Visual search/selective visual attention performance is known to be sensitive to sleep inertia and circadian phase. Individual differences exist in the circadian timing of habitual wake time, which may contribute to individual differences in sleep inertia. Because later chronotypes awaken at an earlier circadian phase, we hypothesized that later chronotypes would have worse visual search performance during sleep inertia than earlier chronotypes if awakened at habitual wake time...
April 4, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28377323/brain-injury-results-in-lower-levels-of-melatonin-receptors-subtypes-mt1-and-mt2
#10
Nicole D Osier, Lan Pham, Bunny J Pugh, Ava Puccio, Dianxu Ren, Yvette P Conley, Sheila Alexander, C Edward Dixon
BACKGROUND: Traumatic brain injury (TBI) is a devastating and costly acquired condition that affects individuals of all ages, races, and geographies via a number of mechanisms. The effects of TBI on melatonin receptors remain unknown. PURPOSE: The purpose of this study is to explore whether endogenous changes in two melatonin receptor subtypes (MT1 and MT2) occur after experimental TBI. SAMPLE: A total of 25 adult male Sprague Dawley rats were used with 6 or 7 rats per group...
April 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28366329/sodium-oxybate-for-idiopathic-rem-sleep-behavior-disorder-a-report-on-two-patients
#11
Keivan Kaveh Moghadam, Fabio Pizza, Alberto Primavera, Raffaele Ferri, Giuseppe Plazzi
BACKGROUND: REM-sleep behavior disorder (RBD) therapy is based on small to medium-sized case series, as no large controlled clinical trials have been performed. The most used and widely recognized effective drugs are clonazepam and melatonin, with anecdotal reports on the potential benefit of other drug classes. METHODS: We report on two patients suffering from idiopathic RBD presenting with almost nightly complex and violent episodes, refractory to conventional drugs...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28365219/study-of-the-efficacy-of-melatonin-for-auditory-brainstem-response-abr-testing-in-children
#12
L Casteil, A Viquesnel, V Favier, N Guignard, C Blanchet, M Mondain
STUDY OBJECTIVE: To evaluate the efficacy of oral melatonin to induce sedation (natural sleep) while measuring auditory brainstem responses (ABR) in children with suspected hearing loss by calculating the ABR success rate with the use of melatonin, the percentage of children in whom sleep was induced by melatonin and the time required to perform complete ABR testing. MATERIAL AND METHODS: Twenty-nine children aged 1 to 6 years were included in this prospective study...
March 29, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28364493/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomized-controlled-study
#13
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
Study Objectives: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364478/common-genetic-variation-near-melatonin-receptor-1a-gene-linked-to-job-related-exhaustion-in-shift-workers
#14
Sonja Sulkava, Hanna M Ollila, Jukka Alasaari, Sampsa Puttonen, Mikko Härmä, Katriina Viitasalo, Alexandra Lahtinen, Jaana Lindström, Auli Toivola, Raimo Sulkava, Mika Kivimäki, Jussi Vahtera, Timo Partonen, Kaisa Silander, Tarja Porkka-Heiskanen, Tiina Paunio
Study Objectives: Tolerance to shift work varies; only some shift workers suffer from disturbed sleep, fatigue, and job-related exhaustion. Our aim was to explore molecular genetic risk factors for intolerance to shift work. Methods: We assessed intolerance to shift work with job-related exhaustion symptoms in shift workers using the emotional exhaustion subscale of the Maslach Burnout Inventory-General Survey, and carried out a genome-wide association study (GWAS) using Illumina's Human610-Quad BeadChip (n = 176)...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364473/prevalence-of-circadian-misalignment-and-its-association-with-depressive-symptoms-in-delayed-sleep-phase-disorder
#15
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha M W Rajaratnam
Study Objective: To examine the prevalence of circadian misalignment in clinically diagnosed delayed sleep phase disorder (DSPD) and to compare mood and daytime functioning in those with and without a circadian basis for the disorder. Methods: One hundred and eighty-two DSPD patients aged 16-64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO)...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28363933/feasibility-of-melatonin-for-prevention-of-delirium-in-critically-ill-patients-a-protocol-for-a-multicentre-randomised-placebo-controlled-study
#16
Lisa Burry, Damon Scales, David Williamson, Jennifer Foster, Sangeeta Mehta, Melanie Guenette, Eddy Fan, Michael Detsky, Azar Azad, Francis Bernard, Louise Rose
INTRODUCTION: Delirium is highly prevalent in the intensive care unit (ICU) and is associated with adverse clinical outcomes. At this time, there is no drug that effectively prevents delirium in critically ill patients. Alterations in melatonin secretion and metabolism may contribute to the development of delirium. Administration of exogenous melatonin has been shown to prevent delirium in non-critically ill surgical and medical patients. This trial will demonstrate the feasibility of a planned multicentre, randomised controlled trial to test the hypothesis that melatonin can prevent delirium in critically ill patients compared with placebo...
March 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28347292/protocol-for-a-randomized-double-blind-placebo-controlled-crossover-trial-of-melatonin-for-treatment-of-nocturia-in-adults-with-multiple-sclerosis-menims
#17
D Delgado, L Canham, N Cotterill, D Cottrell, M J Drake, K Inglis, D Owen, P White
BACKGROUND: Nocturia (the symptom of needing to wake up to pass urine) is common in progressive Multiple Sclerosis (MS) patients. Moderate-to-severe nocturia affects quality of life, can exacerbate fatigue and may affect capacity to carry out daily activities. Melatonin is a natural hormone regulating circadian cycles, released by the pineal gland at night-time, and secretion is impaired in MS. Melatonin levels can be supplemented by administration in tablet form at bedtime. The aim of this study is to evaluate the effect of melatonin on mean number of nocturia episodes per night in MS patients...
March 27, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28331380/classical-conditioning-for-preserving-the-effects-of-short-melatonin-treatment-in-children-with-delayed-sleep-a-pilot-study
#18
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Frans J Oort
Melatonin treatment is effective in treating sleep onset problems in children with delayed melatonin onset, but effects usually disappear when treatment is discontinued. In this pilot study, we investigated whether classical conditioning might help in preserving treatment effects of melatonin in children with sleep onset problems, with and without comorbid attention deficit hyperactivity disorder (ADHD) or autism. After a baseline week, 16 children (mean age: 9.92 years, 31% ADHD/autism) received melatonin treatment for 3 weeks and then gradually discontinued the treatment...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28331379/smartphone-viewing-distance-and-sleep-an-experimental-study-utilizing-motion-capture-technology
#19
Michitaka Yoshimura, Momoko Kitazawa, Yasuhiro Maeda, Masaru Mimura, Kazuo Tsubota, Taishiro Kishimoto
There are studies reporting the negative impact of smartphone utilization on sleep. It is considered that reduction of melatonin secretion under the blue light exposure from smart-phone displays is one of the causes. The viewing distance may cause sleep disturbance, because the viewing distance determines the screen illuminance and/or asthenopia. However, to date, there has been no study closely investigating the impact of viewing distance on sleep; therefore, we sought to determine the relationship between smartphone viewing distance and subjective sleep status...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28327443/correcting-delayed-circadian-phase-with-bright-light-therapy-predicts-improvement-in-adhd-symptoms-a-pilot-study
#20
Rachel E Fargason, Aaron D Fobian, Lauren M Hablitz, Jodi R Paul, Brittny A White, Karen L Cropsey, Karen L Gamble
Attention-deficit/hyperactivity disorder (ADHD) is a common condition with comorbid insomnia reported in >70% of children and adults. These patients demonstrate delays in sleep-wake rhythms, nocturnal rise in melatonin, and early morning rise in cortisol. Given that standard psychopharmacologic treatments for ADHD often do not completely control symptoms in participants with circadian rhythm delay, we sought to test whether bright light therapy (BLT) advances circadian rhythms and further reduces ADHD symptoms over standard treatments...
March 6, 2017: Journal of Psychiatric Research
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