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https://www.readbyqxmd.com/read/28644849/rapid-development-of-cyanobacterial-crust-in-the-field-for-combating-desertification
#1
Chan-Ho Park, Xin Rong Li, Yang Zhao, Rong Liang Jia, Jae-Seoun Hur
Desertification is currently a major concern, and vast regions have already been devastated in the arid zones of many countries. Combined application of cyanobacteria with soil fixing chemicals is a novel method of restoring desertified areas. Three cyanobacteria, Nostoc sp. Vaucher ex Bornet & Flahault, Phormidium sp. Kützing ex Gomont and Scytonema arcangeli Bornet ex Flahault were isolated and tested in this study. Tacki-SprayTM (TKS7), which consists of bio-polysaccharides and tackifiers, was used as a soil fixing agent...
2017: PloS One
https://www.readbyqxmd.com/read/28640518/a-carborane-containing-fluorophore-as-a-stain-of-cellular-lipid-droplets
#2
Andrew Wu, Jacek L Kolanowski, Badwi B Boumelhem, Kylie Yang, Rebecca Lee, Amandeep Kaur, Stuart T Fraser, Elizabeth J New, Louis M Rendina
The use of fluorescent markers and probes greatly enhances biological investigations but relies on the provision of an array of fluorophores with diverse properties. Herein we report a novel carborane-containing coumarin, 5, which is sufficiently lipophilic to localise in cellular lipid droplets. In non-polar solvents which show comparable polarities to those of a lipid environment, compound 5 exhibits a fluorescence quantum yield two orders of magnitude greater than found in aqueous solvents, adding a further degree of selectivity to lipid droplet imaging...
June 22, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28638777/heterobifunctional-dyes-highly-fluorescent-linkers-based-on-cyanine-dyes
#3
Virginia Wycisk, Katharina Achazi, Ole Hirsch, Christian Kuehne, Jens Dernedde, Rainer Haag, Kai Licha
Herein, we present a new synthetic route to cyanine-based heterobifunctional dyes and their application as fluorescent linkers between polymers and biomolecules. The synthesized compounds, designed in the visible spectral range, are equipped with two different reactive groups for highly selective conjugation under physiological conditions. By applying indolenine precursors with functionalized benzenes, we achieved water-soluble asymmetric cyanine dyes bearing maleimido and N-hydroxysuccinimidyl functionalities in a three-step synthesis...
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28637365/insight-into-the-c-f-bond-mechanism-of-molecular-analogs-for-antibacterial-drug-design
#4
Junna Liu, Biyu Lv, Huaqing Liu, Xin Li, Weiping Yin
The activities of biological molecules usually rely on both of intra-molecular and intermolecular interactions between their function groups. These interactions include interonic attraction theory, Van der Waal's forces and the function of geometry on the individual molecules, whether they are naturally or synthetic. The purpose of this study was to evaluate the antibacterial activity of C-F bond compound using combination of experiments verification and theoretical calculation. We target on the insect natural products from the maggots of Chrysomyis megacephala Fabricius...
June 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28636041/fluorescence-properties-of-aurone-derivatives-an-experimental-and-theoretical-study-with-some-preliminary-biological-applications
#5
Christian Espinosa-Bustos, Diego Cortés-Arriagada, Marco A Soto-Arriaza, José Robinson-Duggon, Nancy Pizarro, Alan R Cabrera, Denis Fuentealba, Cristian O Salas
In this paper, we explored the fluorescence properties of eight aurone derivatives bearing methoxy groups and bromine atoms as substituents in the benzene rings. All derivatives showed strong solvatochromic absorption and emission properties in solvents of different polarities. Some of them showed high fluorescence quantum yields, which make them potential compounds for sensing applications. The position of the methoxy groups in the benzofuranone moiety and the presence of bromine atoms in the benzene ring had a strong influence on the fluorescence behaviour of the aurones...
June 21, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28635267/cytochrome-c-provides-an-electron-funneling-antenna-for-efficient-photocurrent-generation-in-a-reaction-center-biophotocathode
#6
Vincent Morris Friebe, Diego Millo, David Swainsbury, Michael R Jones, Raoul N Frese
The high quantum efficiency of photosynthetic reaction centers make them attractive for bioelectronic and biophoto-voltaic applications. However, much of the native reaction center efficiency is lost in communication between surface bound reaction centers and electrode materials. State of the art biophotoelectrodes utilizing cytochrome c (cyt c) as a biological wiring agent have at best approached 32% retained RC quantum efficiency. However, bottlenecks in cyt c -mediated electron transfer have not been fully elucidated...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28633990/cellular-gauge-symmetry-and-the-li-organization-principle-a-mathematical-addendum-quantifying-energetic-dynamics-in-physical-and-biological-systems-through-a-simple-geometric-tool-and-geodetic-curves
#7
REVIEW
Alexander Yurkin, Arturo Tozzi, James F Peters, Pedro C Marijuán
The present Addendum complements the accompanying paper "Cellular Gauge Symmetry and the Li Organization Principle"; it illustrates a recently-developed geometrical physical model able to assess electronic movements and energetic paths in atomic shells. The model describes a multi-level system of circular, wavy and zigzag paths which can be projected onto a horizontal tape. This model ushers in a visual interpretation of the distribution of atomic electrons' energy levels and the corresponding quantum numbers through rather simple tools, such as compasses, rulers and straightforward calculations...
June 17, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28632395/design-synthesis-and-multitarget-biological-profiling-of-second-generation-anti-alzheimer-rhein-huprine-hybrids
#8
Francisco Javier Pérez-Areales, Nibal Betari, Antonio Viayna, Caterina Pont, Alba Espargaró, Manuela Bartolini, Angela De Simone, José Fernando Rinaldi Alvarenga, Belén Pérez, Raimon Sabate, Rosa Maria Lamuela-Raventós, Vincenza Andrisano, Francisco Javier Luque, Diego Muñoz-Torrero
AIM: Simultaneous modulation of several key targets of the pathological network of Alzheimer's disease (AD) is being increasingly pursued as a promising option to fill the critical gap of efficacious drugs against this condition. MATERIALS & METHODS: A short series of compounds purported to hit multiple targets of relevance in AD has been designed, on the basis of their distinct basicities estimated from high-level quantum mechanical computations, synthesized, and subjected to assays of inhibition of cholinesterases, BACE-1, and Aβ42 and tau aggregation, of antioxidant activity, and of brain permeation...
June 20, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28630286/efficient-switching-of-mcherry-fluorescence-using-chemical-caging
#9
Bas M C Cloin, Elke De Zitter, Desiree Salas, Vincent Gielen, Gert E Folkers, Marina Mikhaylova, Maike Bergeler, Bartosz Krajnik, Jeremy Harvey, Casper C Hoogenraad, Luc Van Meervelt, Peter Dedecker, Lukas C Kapitein
Fluorophores with dynamic or controllable fluorescence emission have become essential tools for advanced imaging, such as superresolution imaging. These applications have driven the continuing development of photoactivatable or photoconvertible labels, including genetically encoded fluorescent proteins. These new probes work well but require the introduction of new labels that may interfere with the proper functioning of existing constructs and therefore require extensive functional characterization. In this work we show that the widely used red fluorescent protein mCherry can be brought to a purely chemically induced blue-fluorescent state by incubation with β-mercaptoethanol (βME)...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28628302/highly-fe3-selective-fluorescent-nanoprobe-based-on-ultra-bright-n-p-co-doped-carbon-dots-and-its-application-in-biological-samples
#10
Jingfang Shangguan, Jin Huang, Dinggeng He, Xiaoxiao He, Kemin Wang, Runzhi Ye, Xue Yang, Taiping Qing, Jinlu Tang
Measuring the levels of Fe3+ in human body has attracted considerable attention for health monitoring as it plays an essential element in many physiological processes. In this work, we reported a selective fluorescent nanoprobe for Fe3+ detection in biological samples based on ultra-bright N/P co-doped carbon dots. By employing adenosine 5'-triphosphate (ATP) as the carbon, nitrogen and phosphorus source, the N/P co-doped carbon dots could be simply prepared through hydrothermal treatment. The obtained carbon dots exhibited high quantum yields up to 43...
June 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28626557/electrostatically-driven-resonance-energy-transfer-in-cationic-biocompatible-indium-phosphide-quantum-dots
#11
Gayathri Devatha, Soumendu Roy, Anish Rao, Abhik Mallick, Sudipta Basu, Pramod P Pillai
Indium Phosphide Quantum Dots (InP QDs) have emerged as an alternative to toxic metal ion based QDs in nanobiotechnology. The ability to generate cationic surface charge, without compromising stability and biocompatibility, is essential in realizing the full potential of InP QDs in biological applications. We have addressed this challenge by developing a place exchange protocol for the preparation of cationic InP/ZnS QDs. The quaternary ammonium group provides the much required permanent positive charge and stability to InP/ZnS QDs in biofluids...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28625060/relation-between-vibrational-dephasing-time-and-energy-gap-fluctuations
#12
Maria Ilaria Mallus, Maximilian Schallwig, Ulrich Kleinekathöfer
Dephasing processes are present in basically all applications in which quantum mechanics plays a role. These applications certainly include excitation energy and charge transfer in biological systems. Electronically coupled bacteriochlorophylls within the Fenna-Matthews-Olson and LH2 complexes as well as bilins in PE545 and PE555 aggregates are investigated in an extension of a previous study. It can be concluded that a universal and inverse proportionality exists between dephasing time and average excitonic energy gap fluctuation while the respective proportionality constants can be rationalized using the excitonic gap autocorrelation functions...
June 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28623284/spatio-temporal-steering-for-testing-nonclassical-correlations-in-quantum-networks
#13
Shin-Liang Chen, Neill Lambert, Che-Ming Li, Guang-Yin Chen, Yueh-Nan Chen, Adam Miranowicz, Franco Nori
We introduce the concept of spatio-temporal steering (STS), which reduces, in special cases, to Einstein-Podolsky-Rosen steering and the recently-introduced temporal steering. We describe two measures of this effect referred to as the STS weight and robustness. We suggest that these STS measures enable a new way to assess nonclassical correlations in an open quantum network, such as quantum transport through nano-structures or excitation transfer in a complex biological system. As one of our examples, we apply STS to check nonclassical correlations among sites in a photosynthetic pigment-protein complex in the Fenna-Matthews-Olson model...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621940/on-the-solvation-and-proton-coupled-electron-transfer-reduction-potential-of-2-no-%C3%A2-to-1-hno-in-aqueous-solution-a-theoretical-investigation
#14
Mateus F Venancio, Fabio Doctorovich, Willian Ricardo Rocha
In this work quantum mechanical calculations and Monte Carlo statistical mechanical simulations were carried out to investigate the solvation properties of HNO in aqueous solution and to evaluate the proton coupled one electron reduction potential of 2NO to 1HNO, which are essential missing information to understand the fate of 2NO in the biological medium. Our results showed that the 1HNO molecule acts mainly as hydrogen bond donor in aqueous solution with an average energy of -5.5  1.3 kcal/mol. The solvation free energy of 1HNO in aqueous solution, computed using three approaches based on the Liner Response Theory revealed that the current prediction of the hydration free energy of HNO is, at least, two times underestimated...
June 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28621521/in-situ-live-cell-nucleus-fluorescence-labeling-with-bioinspired-fluorescent-probes
#15
Pan Ding, Houyu Wang, Bin Song, Xiaoyuan Ji, Yuanyuan Su, Yao He
Fluorescent imaging techniques for visualization of nuclear structure and function in live cells are fundamentally important for exploring major cellular events. The ideal cellular labeling method is capable of realizing label-free, in situ, real-time and long-term nucleus labeling in live cells, which can fully obtain the nucleus-relative information and effectively alleviate negative effects of alien probes on cellular metabolism. However, current established fluorescent probes-based strategies (e.g., fluorescent proteins-, organic dyes-, fluorescent organic/inorganic nanoparticles-based imaging techniques) are unable to simultaneously realize label-free, in situ, long-term and real-time nucleus labeling, resulting in inevitable difficulties in fully visualizing nuclear structure and function in live cells...
June 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28621518/a-photoelectrochemical-bioanalysis-platform-for-cells-monitoring-based-on-dual-signal-amplification-using-in-situ-generation-of-electron-acceptor-coupled-with-heterojunction
#16
Ruyan Li, Yue Zhang, Wenwen Tu, Zhihui Dai
Using in suit generation of electron acceptor coupled with heterojunction as dual signal amplification, a simple photoelectrochemical (PEC) bioanalysis platform was designed. The synergic effect between the PEC activities of carbon nitride (C3N4) nanosheets and PbS quantum dots (QDs) achieved almost 9 fold photocurrent intensity increment, compared with the C3N4 alone. After the G-quadruplex/hemin/Pt NPs with catalase-like activity towards H2O2 was introduced, oxygen was in situ generated and acted as electron donor, improving charge separation efficiency and further enhancing photocurrent response...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28621378/the-hypothiocyanite-radical-oscn-and-its-isomers
#17
Zhuang Wu, Jian Xu, Qifan Liu, Xuelin Dong, Dingqing Li, Nicole Holzmann, Gernot Frenking, Tarek Trabelsi, Joseph S Francisco, Xiaoqing Zeng
A biologically relevant reactive sulfur species (RSS), the hypothiocyanite radical OSCN, is generated in the gas phase through flash vacuum pyrolysis (FVP) of trifluoromethyl sulfinyl cyanide CF3S(O)CN at ca. 1000 K. Upon UV light irradiation (365 nm), OSCN rearranges to novel isomers OSNC and SOCN, and further visible light irradiation (400 ± 20 nm) leads to reverse isomerization. The identification of OSCN, OSNC, and SOCN in cryogenic matrices (Ar and N2, 2.8 K) with IR spectroscopy is supported by quantum chemical calculations up to the CCSD(T)-F12/VTZ-F12 level...
June 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28619032/the-role-of-intracellular-trafficking-of-cdse-zns-qds-on-their-consequent-toxicity-profile
#18
Bella B Manshian, Thomas F Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C De Smedt, Jo Demeester, Gareth J S Jenkins, Wolfgang J Parak, Beatriz Pelaz, Shareen H Doak, Uwe Himmelreich, Stefaan J Soenen
BACKGROUND: Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these phenomena is fundamental for the translation of such NPs from in vitro to in vivo systems for bioimaging and medical applications. Two CdSe/ZnS quantum dots (QD) with differing surface functionality (NH2 or COOH moieties) were used here for investigating the intracellular uptake and transport kinetics of these QDs...
June 15, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28614318/robust-real-time-3d-single-particle-tracking-using-a-dynamically-moving-laser-spot
#19
Shangguo Hou, Xiaoqi Lang, Kevin Welsher
Real-time three-dimensional (3D) single-particle tracking uses optical feedback to lock on to freely diffusing nanoscale fluorescent particles, permitting precise 3D localization and continuous spectroscopic interrogation. Here we describe a new method of real-time 3D single-particle tracking wherein a diffraction-limited laser spot is dynamically swept through the detection volume in three dimensions using a two-dimensional (2D) electro-optic deflector and a tunable acoustic gradient lens. This optimized method, called 3D dynamic photon localization tracking (3D-DyPLoT), enables high-speed real-time tracking of single silica-coated non-blinking quantum dots (∼30  nm diameter) with diffusive speeds exceeding 10  μm<sup>2</sup>/s at count rates as low as 10 kHz, as well as YFP-labeled virus-like particles...
June 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28611220/energetics-and-dynamics-of-a-light-driven-sodium-pumping-rhodopsin
#20
Carl-Mikael Suomivuori, Ana P Gamiz-Hernandez, Dage Sundholm, Ville R I Kaila
The conversion of light energy into ion gradients across biological membranes is one of the most fundamental reactions in primary biological energy transduction. Recently, the structure of the first light-activated Na(+) pump, Krokinobacter eikastus rhodopsin 2 (KR2), was resolved at atomic resolution [Kato HE, et al. (2015) Nature 521:48-53]. To elucidate its molecular mechanism for Na(+) pumping, we perform here extensive classical and quantum molecular dynamics (MD) simulations of transient photocycle states...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
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