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https://www.readbyqxmd.com/read/29025859/erratum-direct-substrate-delivery-into-mitochondrial-fission-deficient-pancreatic-islets-rescues-insulin-secretion-diabetes-2017-66-1247-1257
#1
Uma D Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C Woods, Paul T Pfluger, Heiko Lickert, Charles Affourtit, Matthias H Tschöp, Martin Jastroch
No abstract text is available yet for this article.
October 12, 2017: Diabetes
https://www.readbyqxmd.com/read/29025320/efficacy-of-itraconazole-oral-solution-using-an-alternating-week-pulse-therapy-regimen-for-treatment-of-cats-with-experimental-microsporum-canis-infection
#2
Christopher Puls, Aaron Johnson, Karrie Young, Jonathan Hare, Kelly Rosenkrans, Lisa Young, Karen Moriello
Objectives The objective of this study was to evaluate itraconazole 10 mg/ml oral solution for the treatment of Microsporum canis infection using an alternating-week pulse therapy regimen in a controlled laboratory setting. Methods Eighty cats with experimentally induced infections were randomly assigned to treatment (itraconazole vs control [sterile water]), administered 5 mg/kg orally once daily for 1 week on alternate weeks for 5 weeks, followed by a 4 week follow-up period. Topical therapeutic treatment was not administered...
October 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28993235/the-wood-s-lamp-as-a-tool-in-the-evaluation-of-morphea
#3
Paul Curtiss, Gaurav Singh, Kristen Lo Sicco, Andrew G Franks
No abstract text is available yet for this article.
October 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28979623/-piebaldisme-a-rare-genodermatosis
#4
Fatima Zahra Debbarh, Fatima Zahra Mernissi
Piebaldism is a rare autosomal dominant genodermatosis. It is due to congenital absence of melanocytes in the affected areas. We report a case. A 5 year old girl born to consanguineous parents and with similar cases in her mother's; she presented since birth achromic lesions on the legs with a steady evolution. clinical examination showed confluent achromic macules and poliosis (A) with no contrast enhancement under Wood lamp and several coffee-with-milk colored spots on the trunk and thighs(B). The diagnosis of piebaldism was made...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28940653/the-clinicoaetiological-hormonal-and-histopathological-characteristics-of-melasma-in-men
#5
S Handa, D De, G Khullar, B D Radotra, N Sachdeva
BACKGROUND: Melasma is relatively uncommon in males, and there is a paucity of data on male melasma, including its clinical pattern, triggering factors, endocrine profile and histopathological findings. AIM: To characterize the clinical findings and aetiological factors, including hormonal and histopathological features, of male melasma. METHODS: Male patients with melasma and age- and sex-matched healthy controls (HCs) were recruited. Demographic profile, risk factors, clinical pattern and Wood lamp findings of patients were recorded...
September 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28917484/use-of-wood-s-lamp-to-diagnose-progressive-macular-hypomelanosis
#6
Rachel T Pflederer, John Paul Wuennenberg, Caitlyn Foote, Daniel Aires, Anand Rajpara
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28877454/a-stat6-pten-axis-links-regulatory-t-cells-with-adipose-tissue-function
#7
Stefanie Kälin, Maike Becker, Verena B Ott, Isabelle Serr, Fabian Hosp, Mohammad M H Mollah, Susanne Keipert, Daniel Lamp, Francoise Rohner-Jeanrenaud, Victoria K Flynn, Martin G Scherm, Lucas F R Nascimento, Katharina Gerlach, Vanessa Popp, Sarah Dietzen, Tobias Bopp, Purna Krishnamurthy, Mark H Kaplan, Manuel Serrano, Stephen C Woods, Philipp Tripal, Ralf Palmisano, Martin Jastroch, Matthias Blüher, Christian Wolfrum, Benno Weigmann, Anette-Gabriele Ziegler, Matthias Mann, Matthias H Tschöp, Carolin Daniel
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction...
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28799192/wood-s-lamp-for-vitiligo-disease-stability-and-early-recognition-of-initiative-pigmentation-after-epidermal-grafting
#8
Yen-Jen Wang, Chang-Cheng Chang, Kun-Lin Cheng
The prerequisite for a successful vitiligo epidermal grafting surgery is the stable status of the disease. We used Wood's lamp to assess vitiligo activity to determine the disease stability, surgical grafting timing and the early recognition of re-pigmentation after grafting. Amelanotic lesions with sharply demarcated borders are typically stable and are good candidates for grafting. The re-pigmentation was first recognised under Wood's lamp as hypochromic islands, which progressed to normally pigmented islands...
August 10, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28698752/correlation-between-serum-homocysteine-and-vitiligo-area-scoring-index
#9
Dina R U Hasibuan, Imam B Putra, Nelva K Jusuf
BACKGROUND: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity. AIM: To determine correlation between serum homocysteine and vitiligo area Scoring Index (VASI). SUBJECT AND METHOD: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood's lamp examinations then VASI score was determined and same numbers of control...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28516493/diagnosis-and-treatment-of-dermatophytosis-in-dogs-and-cats-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#10
REVIEW
Karen A Moriello, Kimberly Coyner, Susan Paterson, Bernard Mignon
BACKGROUND: Dermatophytosis is a superficial fungal skin disease of cats and dogs. The most common pathogens of small animals belong to the genera Microsporum and Trichophyton. It is an important skin disease because it is contagious, infectious and can be transmitted to people. OBJECTIVES: The objective of this document is to review the existing literature and provide consensus recommendations for veterinary clinicians and lay people on the diagnosis and treatment of dermatophytosis in cats and dogs...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28442876/idiosyncratic-findings-in-trichoscopy-of-tinea-capitis-comma-zigzag-hairs-corkscrew-and-morse-code-like-hair
#11
Ebtisam Elghblawi
Dermoscopy is a method of growing significance in the diagnoses of dermatological pigmented skin diseases. However, in my case, mycology culture was negative and successful treatment was given on the basis of trichoscopy and wood lamp examination. I hereby describe a young boy with tinea capitis, multiple "comma hairs" and "zigzag hair" and a subtle additional feature "Morse code-like hair" when intensification was applied. Dermatoscopic aspects found skin Type 2 in a child of as a distinctive dermoscopic finding...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28405548/clinicoepidemiological-and-mycological-study-of-tinea-capitis-in-the-pediatric-population-of-kashmir-valley-a-study-from-a-tertiary-care-centre
#12
Yasmeen J Bhat, Sumaya Zeerak, Farhat Kanth, Atiya Yaseen, Iffat Hassan, Rubina Hakak
BACKGROUND: Tinea capitis is a superficial fungal infection that predominantly affects the pediatric population. The etiological factors vary from region to region, and the exact incidence remains obscure. The clinicoepidemiological and mycological aspects of this dermatophytosis were studied in a tertiary care centre in Kashmir valley. AIM: To determine the clinicoepidemiological aspects and mycological findings of dermatophytes involved in tinea capitis cases in Kashmir valley...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28400636/a-study-of-vitiligo-in-type-2-diabetic-patients
#13
Leena Raveendra, Rekha N Hemavathi, Sushma Rajgopal
CONTEXT: Diabetes mellitus is associated with many skin manifestations including vitiligo. Vitiligo occurs more commonly in Type 1 diabetes mellitus. A few recent studies have shown its increased occurrence in Type 2 diabetes mellitus. AIMS: This study aims to study the prevalence of vitiligo in Type 2 diabetic patients and to compare the prevalence of vitiligo in age- and sex-matched group of nondiabetic population. SETTINGS AND DESIGN: The present study was a hospital-based cross-sectional study conducted in the Department of Dermatology in a tertiary care hospital...
March 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28212773/a-grayscale-photograph-with-high-dynamic-range-taken-under-a-wood-s-lamp-for-better-recognition-of-vitiligo-lesions
#14
Jung Min Bae, Tae Young Han
No abstract text is available yet for this article.
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28174288/direct-substrate-delivery-into-mitochondrial-fission-deficient-pancreatic-islets-rescues-insulin-secretion
#15
Uma D Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C Woods, Paul T Pfluger, Heiko Lickert, Charles Affourtit, Matthias H Tschöp, Martin Jastroch
In pancreatic β-cells, mitochondrial bioenergetics control glucose-stimulated insulin secretion. Mitochondrial dynamics are generally associated with quality control, maintaining the functionality of bioenergetics. By acute pharmacological inhibition of mitochondrial fission protein Drp1, we demonstrate in this study that mitochondrial fission is necessary for glucose-stimulated insulin secretion in mouse and human islets. We confirm that genetic silencing of Drp1 increases mitochondrial proton leak in MIN6 cells...
May 2017: Diabetes
https://www.readbyqxmd.com/read/28053047/structural-analysis-of-pathogenic-mutations-in-the-dyrk1a-gene-in-patients-with-developmental-disorders
#16
Jochem M G Evers, Roman A Laskowski, Marta Bertolli, Jill Clayton-Smith, Charu Deshpande, Jacqueline Eason, Frances Elmslie, Frances Flinter, Carol Gardiner, Jane A Hurst, Helen Kingston, Usha Kini, Anne K Lampe, Derek Lim, Alison Male, Swati Naik, Michael J Parker, Sue Price, Leema Robert, Ajoy Sarkar, Volker Straub, Geoff Woods, Janet M Thornton, Caroline F Wright
Haploinsufficiency in DYRK1A is associated with a recognizable developmental syndrome, though the mechanism of action of pathogenic missense mutations is currently unclear. Here we present 19 de novo mutations in this gene, including five missense mutations, identified by the Deciphering Developmental Disorder study. Protein structural analysis reveals that the missense mutations are either close to the ATP or peptide binding-sites within the kinase domain, or are important for protein stability, suggesting they lead to a loss of the protein's function mechanism...
February 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/27579541/vitiligo-co-existing-with-lichen-striatus-more-than-a-coincidence
#17
LETTER
J H Chong, D Mermin, J F Goussot, A Taïeb
No abstract text is available yet for this article.
April 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27504543/efficacy-of-trichloro-acetic-acid-peel-alone-versus-combined-topical-magnesium-ascorbyl-phosphate-for-epidermal-melasma
#18
RANDOMIZED CONTROLLED TRIAL
Fatima Murtaza, Abdur Rahim Bangash, Arshad Khushdil, Sahibzada Mahmood Noor
OBJECTIVE: To compare the efficacy in terms of reduction in melasma area and severity index (MASI) score by more than 10 of a combination of 20% trichloro-acetic acid peel plus 5% topical magnesium ascorbyl phosphate versus 20% trichloroacetic acid peel alone in the treatment of epidermal melasma. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Department of Dermatology, Lady Reading Hospital (LRH), Peshawar, from May 2012 to May 2013...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27473262/molecular-identification-of-the-western-drywood-termite-isoptera-kalotermitidae-by-loop-mediated-isothermal-amplification-of-dna-from-fecal-pellets
#19
Tatsuya Ide, Natsumi Kanzaki, Wakako Ohmura, Kimiko Okabe
A rapid and technically simple molecular detection method was developed for the western drywood termite, Incisitermes minor (Hagen), which is among the most harmful pests of wooden architectures. The method features DNA extraction from fecal pellets and species-specific loop-mediated isothermal amplification (LAMP) of DNA. As drywood termites have low moisture requirements, they easily infest artificial wooden products, and are likely to spread by human transportation of infested wood and wooden products. Rapid detection and accurate identification are essential tools for termite eradication at new sites of introduction...
July 29, 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/27432811/the-lived-environment-life-quality-model-for-institutionalized-people-with-dementia
#20
Wendy Wood, Jenna L Lampe, Christina A Logan, Amy R Metcalfe, Beth E Hoesly
BACKGROUND: There is a need for a conceptual practice model that explicates ecological complexities involved in using occupation to optimize the quality of life of institutionalized people with dementia. PURPOSE: This study aimed to prepare the Lived Environment Life Quality Model, a dementia-specific conceptual practice model of occupational therapy in institutional facilities, for publication and application to practice. METHOD: Interviews and focus groups with six expert occupational therapists were subjected to qualitative content analysis to confirm, disconfirm, and further develop the model...
February 2017: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
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