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https://www.readbyqxmd.com/read/27885101/giant-cell-tumor-of-talus-t-construct-method-of-bone-grafting
#1
Abhijeet B Kadam, Anoop C Dhamangaonkar
: Giant cell tumor (GCT) or osteoclastoma is a benign, locally aggressive tumor with a tendency to recur. Giant cell tumors typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and involvement of talus is rare. The authors present a case of GCT of the talar body in a 21-year-old man, which was diagnosed radiologically by the presence of a well-defined osteolytic lesion involving more than half of the talar body with thinning of the cortices...
November 23, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27806844/myxoid-liposarcoma-of-the-foot-a-study-of-8-cases
#2
Elise M Bekers, Wangzhao Song, Albert J H Suurmeijer, Johannes J Bonenkamp, Ingrid C van der Geest, Petra M Braam, Marieke J M Ploegmakers, Ingrid M E Desar, Bastiaan B J Tops, Joost M van Gorp, David H Creytens, Thomas Mentzel, Uta Flucke
INTRODUCTION: Myxoid liposarcoma is the only translocation-associated liposarcoma subtype. It classically originates in the deep soft tissues of the thigh. At distal sites of the extremities, this tumor is exceedingly rare. We present a series of 8 cases occurring in the foot/ankle. RESULTS: Two female and 6 male patients, aged between 32 and 77 years (mean, 54.3 years), were identified. Tumor size ranged from 1.1 to 10 cm (mean, 6.8 cm). Two lesions eroded bone...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27799977/cytodiagnosis-of-chondromyxoidfibroma-of-the-metatarsal-head-a-case-report
#3
Bushra Siddiqui, ShahbazHabib Faridi, Mohd Faizan, Rana K Sherwani
Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor with a predilection for the bones of lower extremities and about one fourth of the tumors involve the foot. Radiologically, an eccentric lytic lesion with well-defined margins is seen in the metaphysis of the bone. We hereby, report an 18 yr old young male who presented to Orthopedic Outpatient Department, JN Medical College, Aligarh Muslim University, India diagnosed with giant cell tumor of the third metatarsal bone of right foot on radiography but on fine needle aspiration cytology (FNAC) the diagnosis of CMF was made...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27708968/a-case-of-systemic-lupus-erythematosus-with-multiple-nodules-in-the-bilateral-lungs-and-vertebrae
#4
Takuma Tsuzuki Wada, Kojiro Sato, Toshihide Mimura
We encountered a case of a middle-aged woman with systemic lupus erythematosus. As the patient had progressive peripheral neuropathy including foot drop, we intended to treat her with intensive immunosuppressive therapy as soon as possible. Pretreatment assessment, however, revealed multiple nodular lesions in the lungs and bones, suggesting disseminated tumor metastasis or miliary tuberculosis. To our surprise, gallium and bone scintigraphy as well as cytodiagnosis revealed no sign of malignancy or infection, leading us to suspect the presence of another multisystem disorder...
March 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27698855/aneurysmal-bone-cyst-of-the-metatarsal-a-case-report
#5
Jiangyinzi Shang, Runsheng Guo, Ping Zhan, Chuwen Chen, Jing Kan, Hucheng Liu, Min Dai
An aneurysmal bone cyst (ABC) is a rare, non-neoplastic, destructive, hemorrhagic and expansile lesion accounting for 1% of all bone tumors. This type of lesion predominantly affects long bones and vertebrae. ABC of the metatarsal is rare and only a few cases have been reported in the literature to date. The present study reports a rare case of ABC of the third metatarsal occurring in a 27-year-old male patient, who presented with repeated foot swelling that had lasted for ~1 year. Other clinical manifestations included limping, multiple lumps (defined as masses on or below the skin, as detected by imageological diagnosis) and progressively increasing local pain in his right foot...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27686674/constitutional-t-8-22-q24-q11-2-that-mimics-the-variant-burkitt-type-translocation-in-philadelphia-chromosome-positive-chronic-myeloid-leukemia
#6
Shinichiro Kawamoto, Katsuya Yamamoto, Masanori Toyoda, Kimikazu Yakushijin, Hiroshi Matsuoka, Hironobu Minami
Constitutional translocations that coincide with t(9;22)(q34;q11.2) may lead to unnecessary treatments in chronic myeloid leukemia (CML) patients, as, under the standard criteria, a diagnosis of CML with additional chromosomal abnormalities indicates an accelerated phase (AP). In the present report, a 47-year-old male had pain in the right foot due to gout. Peripheral blood examination showed leukocytosis with left shift. Bone marrow aspiration revealed myeloid hyperplasia with megakaryocytosis. RT-PCR revealed the major BCR-ABL fusion transcript, and CML in the chronic phase was diagnosed, followed by nilotinib treatment...
September 29, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27677041/posterior-intraductal-lombar-tumor%C3%A2-about-a-migration-disc
#7
Samia Frioui Mahmoudi, Emna Toulgui, Sonia Jemni, Khalil Ben Jeddou, Mariem Gaddour, Afif Zaoui, Faycel Khachnaoui
OBJECTIVE: To talk through our observation and a review of the literature about radiological features and diagnostic difficulties of this particular form of disk migration. OBSERVATIONS: We report the case of a 29 year-old patient who presented following the wearing of a heavy load bilateral acute lombosciatalgies associated with a deficit of both lower limbs and urinary incontinence. Clinical examination revealed a motor deficit of sural triceps and foot relievers estimated1 in bilateral, hypoesthesia of the anterolateral side of the two legs and the feet, low bone tendon reflexes were abolished, anesthesia in the saddle, hypotonic anal sphincter and bladder distension...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27614921/en-bloc-excision-and-matched-metatarsal-transfer-for-expansive-benign-osteolytic-lesions-of-the-metacarpal
#8
Samuel C R Pallapati, Binu Prathap Thomas, George A Anderson
PURPOSE: Benign aggressive expansile osteolytic lesions such as giant cell tumors and aneurysmal bone cysts involving the metacarpal head pose problems in management. Unacceptably high rates of recurrence are reported after curettage and bone grafting. An en bloc excision of such tumors ideally requires osteoarticular replacement of the excised metacarpal heads to retain mobility and function. We used nonvascularized metatarsal head and shaft harvested from the foot to replace the metacarpal defect after en bloc resection to retain movement and function of metacarpophalangeal (MCP) joint...
September 7, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27594952/intra-articular-osteoid-osteoma-of-the-calcaneus-a-case-report-and-review
#9
Tomo Hamada, Hidenori Matsubara, Hiroaki Kimura, Takao Aikawa, Yasuhisa Yoshida, Hiroyuki Tsuchiya
Osteoid osteoma of the calcaneus is rare and frequently misdiagnosed as arthritis because of similar symptoms. In addition, radiographic findings may be nonspecific, and magnetic resonance imaging (MRI) may show a bone marrow edema and changes in adjacent soft tissue. A 19-year-old man presented with a 6-month history of persistent pain and swelling in the left hind foot; diagnostic computed tomography and MRI analyses revealed lesions suggesting an intra-articular osteoid osteoma of the calcaneus. Initial MRI did not show specific findings...
September 2016: Radiology case reports
https://www.readbyqxmd.com/read/27510684/a-rare-case-of-multifocal-pseudomyogenic-hemangioendothelioma-involving-soft-tissues-and-bone-misdiagnosed-as-a-rhabdomyosarcoma-diagnostic-and-treatment-implications
#10
Bharat Rekhi, Ashish Gulia, Venkatesh Rangarajan
Pseudomyogenic hemangioendothelioma (PHE) is an uncommon, but distinctive soft tissue tumor, characterized by multifocality. A 17-year-old male referred to us with progressively increasing multiple subcutaneous nodular lesions over his left leg and foot, reported elsewhere as a spindle cell rhabdomyosarcoma. On review, microscopy showed a cellular tumor comprising plump spindle cells arranged in loose fascicles with interspersed inflammatory cells. Tumor cells exhibited mild nuclear variation. Immunohistochemically, tumor cells expressed AE1/AE3, CD31, Fli-1, and smooth muscle actin (SMA), confirming diagnosis of PHE...
July 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27474831/myositis-ossificans-a-rare-location-in-the-foot-report-of-a-case-and-review-of-literature
#11
Qays Ahmed Hassan Al-Timimy, Mohammed Shehab Al-Edani
BACKGROUND: Myositis ossificans is a benign, tumor-like lesion characterized by heterotopic ossification of soft tissue that usually affects the elbow and thigh. At different stages of maturity, it show similar histologic appearances with sarcomatous lesions or maturing bone. Misdiagnosis can result in unnecessary radical treatment. CASE REPORT: A 50-year-old woman with dorsal forefoot soft tissue mass was diagnosed as myositis ossificans after surgical excision and confirmed by a histopathological examination...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27421768/evaluation-of-intraarterial-and-intravenous-cisplatin-chemotherapy-in-the-treatment-of-metastatic-osteosarcoma-using-an-orthotopic-xenograft-mouse-model
#12
Bernhard Robl, Sander Martijn Botter, Giovanni Pellegrini, Olga Neklyudova, Bruno Fuchs
BACKGROUND: Osteosarcoma is the most common primary malignancy of bone. Its treatment relies on the administration of neoadjuvant and adjuvant chemotherapy combined with surgery. Alternative to common intravenous (i.v.) administration of chemotherapeutic drugs, clinical studies also evaluated the benefit of intraarterial (i.a.) administrations. However, conflicting results were obtained when both routes of administration of cisplatin (CDDP), a gold standard drug in osteosarcoma treatment, were compared...
2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27324025/structural-allograft-reconstruction-of-the-foot-and-ankle-after-tumor-resections
#13
M A Ayerza, N S Piuzzi, L A Aponte-Tinao, G L Farfalli, D L Muscolo
BACKGROUND: Structural allografts have been used to correct deformities or to fill bone defects secondary to tumor excisions, trauma, osteochondral lesions, or intercalary arthrodesis. However, the quality of published evidence supporting the use of allograft transplantation in foot and ankle surgery has been reported as fair. The purpose of this study was to report the overall survival of structural allograft in the foot and ankle after tumor resection, and the survival according to the type of allograft and the complication rates in the medium to long term...
August 2016: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/27317211/imaging-findings-of-various-talus-bone-tumors-clinico-radiologic-features-of-talus-bone-tumors
#14
REVIEW
Ji Young Jeon, Hye Won Chung, Jong Won Kwon, Sung Hwan Hong, Guen Young Lee, Kyung Nam Ryu
Osseous neoplasms of the foot are uncommon, accounting for only 3.3% of all primary bone tumors. Bone tumors of the talus are even rarer, and there are not many publications that comprehensively evaluate the imaging findings of talus tumors. The purpose of this article is to review the benign and malignant bone tumors affecting this uncommon site and to describe the clinical and radiologic features of each tumor.
July 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27279998/subungual-ewing-sarcoma-pnet-tumor-family-of-the-great-toe-a-case-report
#15
Fariba Binesh, Mohammad Sobhanardekani, Saeedeh Zare, Nasim Behniafard
Ewing's sarcoma is seen mainly in patients less than 18. This aggressive tumor generally affects the axial skeleton and only rarely involves the acral regions. Ewing's sarcoma in the foot is inordinately scarce. Clinical features are uncertain and can imitate other common diseases. This paper presents a case of 62-year-old malewith complaints of pain and swelling of the subungual area of his right great toe. The lesion was excised, and histopathological diagnosis of Ewing's sarcoma was made. Histopathological examination, supported by immunochemical methods, remains the mainstay of diagnosis...
April 2016: Electronic Physician
https://www.readbyqxmd.com/read/27273935/effect-of-music-therapy-on-pain-behaviors-in-rats-with-bone-cancer-pain
#16
Ji Gao, Shaoqin Chen, Suyong Lin, Hongjing Han
PURPOSE: To investigate the effects of music therapy on the pain behaviors and survival of rats with bone cancer pain and analyze the mediating mechanism of mitogen activated protein kinase (MAPK) signal transduction pathway. METHODS: Male Wistar rats aged 5-8 weeks and weighing 160-200 g were collected. The rat models of colorectal cancer bone cancer pain was successfully established. Animals were divided into experimental and control group, each with 10 rats. The animals in the observation group were given Mozart K448 sonata, sound intensity of 60 db, played the sonata once every 1 hr in the daytime, stopped playing during the night, and this cycle was kept for 2 weeks...
March 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27158400/activation-of-spinal-mrgc-gi-nr2b-nnos-signaling-pathway-by-mas-oncogene-related-gene-c-receptor-agonist-bovine-adrenal-medulla-8-22-attenuates-bone-cancer-pain-in-mice
#17
Yu'e Sun, Juan Zhang, Yishan Lei, Cui'e Lu, Bailing Hou, Zhengliang Ma, Xiaoping Gu
OBJECTIVES: In the present study, we investigate the effects of Mas oncogene-related gene (Mrg) C receptors (MrgC) on the expression and activation of spinal Gi protein, N-methyl-D-aspartate receptor subunit 2B (NR2B), and neuronal nitric oxide synthase (nNOS) in mouse model of bone cancer pain. METHODS: The number of spontaneous foot lift (NSF) and paw withdrawal mechanical threshold (PWMT) were measured after inoculation of tumor cells and intrathecal injection of MrgC agonist bovine adrenal medulla 8-22 (BAM8-22) or MrgC antagonist anti-MrgC for 14 days after operation...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27111078/ipsilateral-nonvascularized-autograft-and-periosteal-repair-for-the-treatment-of-pediatric-tumors-of-the-distal-fibula
#18
Caleb M Yeung, Santiago A Lozano-Calderón, Benjamin Allar, Manahil Naqvi, Mark C Gebhardt, Megan E Anderson
Resection of the distal fibula is used to treat malignant or benign locally aggressive tumors involving this region. Current reconstructive techniques are limited by undesirable functional deficits. The authors present a part-retrospective and part-prospective case-comparison of 2 patient groups (study and control) treated for malignant or benign locally aggressive primary bone tumors of the distal fibula. Patients in the study group underwent a novel surgical technique involving distal transportation of the ipsilateral proximal portion of the fibula after periosteal dissection and osteotomy with subsequent proximal periosteal reconstruction...
July 1, 2016: Orthopedics
https://www.readbyqxmd.com/read/27106295/first-report-of-an-aneurysmal-bone-cyst-presenting-as-subungual-mass
#19
Cornelia Sigrid Lissi Müller, Yoo-Jin Kim, Katrin Koch, Günther Schneider, Claudia Pföhler, Dieter Kohn, Thomas Vogt, Daniel Baumhoer
Painful subungual tumor masses in the toes usually emerge as glomus tumors or subungual exostoses. We present a patient with an aneurysmal bone cyst located subungually in whom the diagnosis was delayed due to inadequate diagnostic procedures, which led to marked destruction of the distal phalanx of the great toe of the right foot. After biopsy, the distal phalanx could not be preserved due to critical soft tissue involvement and the size of the process. Thus, we describe this rare entity to encourage clinicians to establish the diagnosis by biopsy of a tissue swelling of unclear origin and duration that does not resolve after a short time...
August 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27031385/unicameral-bone-cyst-of-the-medial-cuneiform-a-case-report
#20
Faith A Schick, Joseph N Daniel, Juliane S Miller
A unicameral bone cyst is a relatively uncommon, benign bone tumor found in the metaphysis of long bones, such as the humerus and the femur, in skeletally immature persons. In the foot, these benign, fluid-filled cavities are most commonly found within the os calcis. We present a case report of a 10-year-old female with a unicameral bone cyst of the medial cuneiform.
March 31, 2016: Journal of the American Podiatric Medical Association
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