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https://www.readbyqxmd.com/read/27909274/-three-mitral-valve-operations-in-a-patient-with-trousseau-syndrome-and-nonbacterial-thrombotic-endocarditis-caused-by-ovarian-cancer
#1
Masahito Saito, Naoki Asano, Kazunori Ota, Kazuho Niimi, Koyu Tanaka, Shigeyoshi Gon, Hiroshi Takano
A 52-year-old woman was admitted to our hospital for acute right hemi-paresis, left homonymous hemianopia, and fever. Magnetic resonance imaging of the brain showed multiple cerebral infarctions and transesophageal echocardiography (TEE) revealed a vegetation on the posterior leaflet of her mitral valve. Mitral valve repair was performed under a diagnosis of infective endocarditis (IE). Further multiple cerebral infarctions occurred on the 11th postoperative day, resulting in left hemiplegia and dysarthria...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27900226/laparoscopic-extirpation-of-a-schwannoma-in-the-lateral-pelvic-space
#2
Eiji Hidaka, Yasuhiro Ishiyama, Chiyo Maeda, Kenta Nakahara, Shoji Shimada, Shumpei Mukai, Naruhiko Sawada, Fumio Ishida, Shin-Ei Kudo
Schwannomas in the lateral pelvic space are very rare. Here, we report the case of a 48-year-old woman who had a tumor detected in her abdomen by abdominal ultrasonography. Abdominal computed tomography and magnetic resonance imaging revealed a well-defined solid tumor of 65 mm in diameter in the right lateral pelvic space. We performed laparoscopic surgery under a diagnosis of a gastrointestinal tumor or neurogenic tumor. The tumor was safely dissected and freed from the surrounding tissues using sharp and blunt maneuvers...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27891147/effect-of-neoadjuvant-chemoradiotherapy-with-capecitabine-versus-fluorouracil-for-locally-advanced-rectal-cancer-a-meta-analysis
#3
REVIEW
Guo-Chen Liu, Jun-Ping Yan, Qing He, Xin An, Zhi-Zhong Pan, Pei-Rong Ding
A meta-analysis was carried out to compare the efficacy and safety of capecitabine plus radiation with 5-fluorouracil (5-FU) plus radiotherapy (RT) as neoadjuvant treatment in locally advanced rectal cancer (LARC). We searched the Cochrane database, Ovid, Medline, Embase, ISI databases, and Chinese Biomedical Literature Database between January 1998 and October 2014. Trials of capecitabine compared with 5-FU plus RT as neoadjuvant treatment for LARC were considered for inclusion. RevMan software was used to analyze these data...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27888846/mr-imaging-of-common-soft-tissue-masses-in-the-foot-and-ankle
#4
REVIEW
Mary G Hochman, Jim S Wu
Soft tissue masses may be encountered in the foot and ankle and may represent true neoplasms, malignant or benign, or other, nonneoplastic entities that mimic musculoskeletal tumors. This article reviews common soft tissue masses encountered in the foot or ankle, highlights their MR imaging appearance, and outlines common pitfalls. Technical considerations for imaging soft tissue masses in the foot and ankle are discussed. On MR imaging, T1-weighted and T2-weighted signal intensity, contrast enhancement characteristics, and lesion location, together with patient demographics, history and physical examination, and findings on radiographs, can be useful in characterizing masses in the foot and ankle...
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27885101/giant-cell-tumor-of-talus-t-construct-method-of-bone-grafting
#5
Abhijeet B Kadam, Anoop C Dhamangaonkar
: Giant cell tumor (GCT) or osteoclastoma is a benign, locally aggressive tumor with a tendency to recur. Giant cell tumors typically occur in the epiphysis of long bones, including the distal femur and proximal tibia. They are uncommonly found in the small bones of the foot or ankle, and involvement of talus is rare. The authors present a case of GCT of the talar body in a 21-year-old man, which was diagnosed radiologically by the presence of a well-defined osteolytic lesion involving more than half of the talar body with thinning of the cortices...
November 23, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/27870729/aggressive-digital-papillary-adenocarcinoma-with-multiple-organ-metastases-a-case-report-and-review-of-the-literature
#6
Tadahiro Kobayashi, Azusa Hiura, Kyosuke Oishi, Shintaro Maeda, Andres James Le Pavoux, Kuniaki Ohara, Hironori Uruga
Aggressive digital papillary adenocarcinoma (ADPA) is a rare sweat gland neoplasm with a high recurrence rate and metastatic potential. In this study, the authors describe a case that originally appeared to benign spiradenoma, but took an ominous course eventually resulting in the diagnosis of ADPA. A 73-year-old woman developed a gradually growing nodule on the second toe of her left foot, which she had first noticed 4 years previously. An excisional biopsy was performed followed by histological examination...
December 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27861496/clinical-characteristics-of-malignant-melanoma-in-southwest-china-a-single-center-series-of-82-consecutive-cases-and-a-meta-analysis-of-958-reported-cases
#7
Jia Yu, Xue Luo, Hui Huang, Zhifang Zhai, Zhu Shen, Hui Lin
PURPOSE: The present study determined the clinical characteristics and prognostic factors in patients with malignant melanoma based on a series of 82 cases from January 2009 to December 2014 in Southwest Hospital and a meta-analysis (including 12 articles) involving 958 patients in China. MATERIALS AND METHODS: The database elements included basic demographic data and prognosticators which were extracted from medical records. Statistical analyses of survival, and multivariate analyses of factors associated with survival were performed using the Kaplan-Meier method, and the Cox proportional hazard model, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27851693/the-correlation-between-recordable-meps-and-motor-function-during-spinal-surgery-for-resection-of-thoracic-spinal-cord-tumor
#8
LanJun Guo, Yan Li, Ruquan Han, Adrian W Gelb
BACKGROUND: Motor evoked potentials (MEPs) are commonly used during surgery for spinal cord tumor resection. However, it can be difficult to record reliable MEPs from the muscles of the lower extremities during surgery in patients with preoperative weakness due to spinal cord compression. In this study, motor function of patients' lower extremities and their association with intraoperative MEP recording were compared. PATIENTS AND METHODS: Patients undergoing thoracic spinal cord tumor resection were studied...
November 15, 2016: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/27849649/a-multicenter-phase-ii-study-of-gemcitabine-capecitabine-and-bevacizumab-for-locally-advanced-or-metastatic-biliary-tract-cancer
#9
Renuka V Iyer, Venkata K Pokuri, Adrienne Groman, Wen W Ma, Usha Malhotra, Dan M Iancu, Catherine Grande, Tanios B Saab
OBJECTIVES: Vascular endothelial growth factor overexpression, seen in 42% to 76% of biliary tract cancers (BTCs), correlates with poor survival. We explored the safety/efficacy and potential biomarkers for bevacizumab in combination with gemcitabine-capecitabine in advanced BTCs. PATIENTS AND METHODS: Inoperable stage III/IV BTC patients in our prospective study were given 1000 mg/m of gemcitabine (on days 1, 8), 650 mg/m of capecitabine (on days 1 to 14), and 15 mg/kg of bevacizumab (on day 1) in 21-day cycles...
November 15, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27810034/primary-synovial-chondromatosis-of-the-talonavicular-joint-a-case-report
#10
Jun-Beom Kim, In-Soo Song, Sang-Yeop Shin, Ja-Yeong Yoon
Synovial chondromatosis developes by metaplasia of the synovial cells in the synovium of joints, and is a benign synovial tumor with multiple cartilaginous nodules. It is most commonly found in single and large joints, such as the knee, hip, and shoulder. Occurrence in the foot and ankle is uncommon, although there have been previous reports in the orthopedic and radiological literature of primary synovial chondromatosis in the subtalr, calcaneocuboid, naviculocuneiform, and metatarsaophalangeal joints. To our knowledge, occurrence in the talonavicular joint is even rarer, with only one report in the literature to date...
December 2016: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27806844/myxoid-liposarcoma-of-the-foot-a-study-of-8-cases
#11
Elise M Bekers, Wangzhao Song, Albert J H Suurmeijer, Johannes J Bonenkamp, Ingrid C van der Geest, Petra M Braam, Marieke J M Ploegmakers, Ingrid M E Desar, Bastiaan B J Tops, Joost M van Gorp, David H Creytens, Thomas Mentzel, Uta Flucke
INTRODUCTION: Myxoid liposarcoma is the only translocation-associated liposarcoma subtype. It classically originates in the deep soft tissues of the thigh. At distal sites of the extremities, this tumor is exceedingly rare. We present a series of 8 cases occurring in the foot/ankle. RESULTS: Two female and 6 male patients, aged between 32 and 77 years (mean, 54.3 years), were identified. Tumor size ranged from 1.1 to 10 cm (mean, 6.8 cm). Two lesions eroded bone...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27799977/cytodiagnosis-of-chondromyxoidfibroma-of-the-metatarsal-head-a-case-report
#12
Bushra Siddiqui, ShahbazHabib Faridi, Mohd Faizan, Rana K Sherwani
Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor with a predilection for the bones of lower extremities and about one fourth of the tumors involve the foot. Radiologically, an eccentric lytic lesion with well-defined margins is seen in the metaphysis of the bone. We hereby, report an 18 yr old young male who presented to Orthopedic Outpatient Department, JN Medical College, Aligarh Muslim University, India diagnosed with giant cell tumor of the third metatarsal bone of right foot on radiography but on fine needle aspiration cytology (FNAC) the diagnosis of CMF was made...
2016: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/27788421/profile-of-autonomic-dysfunctions-in-patients-with-primary-brain-tumor-and-possible-autoimmunity
#13
Magdalena Koszewicz, Slawomir Michalak, Malgorzata Bilinska, Slawomir Budrewicz, Mikolaj Zaborowski, Krzysztof Slotwinski, Ryszard Podemski, Maria Ejma
OBJECTIVE: Cerebral lesion due to different neurological conditions could be complicated by autonomic dysfunction, reported in the literature as a sympathetic hyperactivity. The mechanisms of dysautonomia still remains partial. The aim of the study was to assess the profile of autonomic dysfunction in patient with primary brain tumors, with attempt to estimate the additional factors in pathogenesis of dysautonomia. MATERIAL AND METHODS: Neurological examinations, the Low's autonomic disorder questionnaire, electrophysiological autonomic tests (Heart Rate Variability test at rest and during deep breathing, spectral analysis of R-R intervals, sympathetic skin response test), studies of peripheral nerves, blood sampling collection for antibodies were done in 33 patients with recognized primary brain tumors...
October 22, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27784746/crlx101-a-nanoparticle-drug-conjugate-containing-camptothecin-improves-rectal-cancer-chemoradiotherapy-by-inhibiting-dna-repair-and-hif-1%C3%AE
#14
Xi Tian, Minh Nguyen, Henry Putnam Foote, Joseph M Caster, Kyle C Roche, Christian G Peters, Pauline Wu, Lata Jayaraman, Edward G Garmey, Joel E Tepper, Scott Eliasof, Andrew Z Wang
Novel agents are needed to improve chemoradiotherapy for locally advanced rectal cancer. In this study, we assessed the ability of CRLX101, an investigational nanoparticle-drug conjugate containing the payload camptothecin (CPT), to improve therapeutic responses as compared to standard chemotherapy. CRLX101 was evaluated as a radiosensitizer in colorectal cancer cell lines and murine xenograft models. CRLX101 was as potent as CPT in vitro in its ability to radiosensitize cancer cells. Evaluations in vivo demonstrated that the addition of CRLX101 to standard chemoradiotherapy significantly increased therapeutic efficacy by inhibiting DNA repair and HIF-1α pathway activation in tumor cells...
October 26, 2016: Cancer Research
https://www.readbyqxmd.com/read/27769969/management-of-neuroendocrine-tumors
#15
Clement Chung
PURPOSE: Current strategies for managing neuroendocrine tumors (NETs) in adult patients are reviewed, with a focus on medication safety concerns. SUMMARY: NETs usually originate in the gastrointestinal or bronchopulmonary tract. Symptoms due to hormonal hypersecretion often occur in patients with foregut or midgut NETs or liver metastases. Surgical resection is recommended for most localized NETs, while systemic cytotoxic chemotherapy is typically used for high-grade and pancreatic tumors...
November 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27764139/prevalence-of-glomerulopathies-in-canine-mammary-carcinoma
#16
Leandro Z Crivellenti, Gyl E B Silva, Sofia Borin-Crivellenti, Rachel Cianciolo, Christopher A Adin, Márcio Dantas, Denner S Dos Anjos, Mirela Tinucci-Costa, Aureo E Santana
The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy...
2016: PloS One
https://www.readbyqxmd.com/read/27752847/metronomic-chemotherapy-with-oral-vinorelbine-mvnr-and-capecitabine-mcape-in-advanced-her2-negative-breast-cancer-patients-is-it-a-way-to-optimize-disease-control-final-results-of-the-victor-2-study
#17
M E Cazzaniga, L Cortesi, A Ferzi, L Scaltriti, F Cicchiello, M Ciccarese, S Della Torre, F Villa, M Giordano, C Verusio, M Nicolini, A R Gambaro, L Zanlorenzi, E Biraghi, L Legramandi, E Rulli
PURPOSE: The VICTOR-1 study demonstrated that the all-oral metronomic combination of vinorelbine and capecitabine is highly active and well tolerated in hormone receptor-positive/HER2-negative patients. The VICTOR-2 study was designed to confirm these results. METHODS: Patients received mVNR 40 mg three times a week and mCAPE 500 mg three times a day, continuously. The primary endpoint was the clinical benefit rate (CBR); secondary endpoints were toxicity, objective response rate (ORR), and progression-free survival (PFS)...
December 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27751846/safety-and-efficacy-of-regorafenib-in-patients-with-advanced-soft-tissue-sarcoma-regosarc-a-randomised-double-blind-placebo-controlled-phase-2-trial
#18
Olivier Mir, Thomas Brodowicz, Antoine Italiano, Jennifer Wallet, Jean-Yves Blay, François Bertucci, Christine Chevreau, Sophie Piperno-Neumann, Emmanuelle Bompas, Sébastien Salas, Christophe Perrin, Corinne Delcambre, Bernadette Liegl-Atzwanger, Maud Toulmonde, Sarah Dumont, Isabelle Ray-Coquard, Stéphanie Clisant, Sophie Taieb, Cécile Guillemet, Maria Rios, Olivier Collard, Laurence Bozec, Didier Cupissol, Esma Saada-Bouzid, Christine Lemaignan, Wolfgang Eisterer, Nicolas Isambert, Loïc Chaigneau, Axel Le Cesne, Nicolas Penel
BACKGROUND: Regorafenib is a multikinase inhibitor with proven activity in refractory gastrointestinal stromal tumours and chemotherapy-refractory advanced colorectal cancers. We assessed this agent's efficacy and safety in patients with metastatic soft tissue sarcomas previously treated with anthracycline. METHODS: In this randomised, double-blind, phase 2 trial undertaken in France and Austria, we enrolled patients aged 18 years and older with advanced soft tissue sarcomas who had received previous doxorubicin or other anthracycline treatment...
October 14, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27745968/percutaneous-image-guided-cryoablation-of-musculoskeletal-metastases-pain-palliation-and-local-tumor-control
#19
Adam N Wallace, Sebastian R McWilliams, Sarah E Connolly, John S Symanski, Devin Vaswani, Anderanik Tomasian, Ross Vyhmeister, Ashley M Lee, Thomas P Madaelil, Travis J Hillen, Jack W Jennings
PURPOSE: To evaluate the safety and effectiveness of cryoablation of musculoskeletal metastases in terms of achieving pain palliation and local tumor control. MATERIALS AND METHODS: A retrospective review was performed of 92 musculoskeletal metastases in 56 patients treated with percutaneous image-guided cryoablation. Mean age of the cohort was 53.9 y ± 15.1, and cohort included 48% (27/56) men. Median tumor volume was 13.0 cm(3) (range, 0.5-577.2 cm(3)). Indications for treatment included pain palliation (41%; 38/92), local tumor control (15%; 14/92), or both (43%; 40/92)...
December 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27716285/safety-pharmacokinetics-and-antitumor-properties-of-anlotinib-an-oral-multi-target-tyrosine-kinase-inhibitor-in-patients-with-advanced-refractory-solid-tumors
#20
Yongkun Sun, Wei Niu, Feng Du, Chunxia Du, Shuting Li, Jinwan Wang, Li Li, Fengqing Wang, Yu Hao, Chuan Li, Yihebali Chi
BACKGROUND: Anlotinib is a novel multi-target tyrosine kinase inhibitor that is designed to primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. We aimed to evaluate the safety, pharmacokinetics, and antitumor activity of anlotinib in patients with advanced refractory solid tumors. METHODS: Anlotinib (5-16 mg) was orally administered in patients with solid tumor once a day on two schedules: (1) four consecutive weeks (4/0) or (2) 2-week on/1-week off (2/1)...
October 4, 2016: Journal of Hematology & Oncology
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