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https://www.readbyqxmd.com/read/29327075/phase-ii-study-of-sorafenib-combined-with-concurrent-hepatic-arterial-infusion-of-oxaliplatin-5-fluorouracil-and-leucovorin-for-unresectable-hepatocellular-carcinoma-with-major-portal-vein-thrombosis
#1
Min-Ke He, Ru-Hai Zou, Qi-Jiong Li, Zhong-Guo Zhou, Jing-Xian Shen, Yong-Fa Zhang, Zi-Shan Yu, Li Xu, Ming Shi
BACKGROUND: Sorafenib is recommended for the first-line treatment of advanced hepatocellular carcinoma (HCC). However, the median progression-free survival (PFS) of patients with HCC and major portal vein tumor thrombosis treated with sorafenib monotherapy is no more than 3 months. A prospective single-arm phase II study was conducted to determine whether adding hepatic arterial infusion chemotherapy of oxaliplatin, 5-fluorouracil and leucovorin to sorafenib could improve on these results...
January 11, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29322209/infiltrating-angiolipoma-of-the-foot-magnetic-resonance-imaging-features-and-review-of-the-literature
#2
Eui Dong Yeo, Bo Mi Chung, Eun Ju Kim, Wan Tae Kim
Angiolipoma is a benign soft tissue tumor with two subtypes: non-infiltrating and infiltrating. Although histologically benign, infiltrating angiolipoma can invade surrounding structures. The foot is a very rare location for angiolipoma, with only four cases reported in the English literature, including one infiltrating type. Here, we report a very rare case of infiltrating angiolipoma of the foot with magnetic resonance imaging (MRI) and ultrasonography (US) findings. A 7-year-old boy presented with a slowly growing foot mass...
January 10, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29310463/plantar-fibromatosis-pathophysiology-surgical-and-nonsurgical-therapies-an-evidence-based-review
#3
Paul Carroll, Robert M Henshaw, Caitlin Garwood, Katherine Raspovic, Dhruv Kumar
Plantar fibromatosis (morbus Ledderhose), an extra-abdominal desmoid tumor of the plantar foot, is a rare benign hyperproliferative disorder of the plantar fascia with an unknown etiology. The main clinical characteristics include slow growing nodules on the medial and central bands of the plantar fascia, which may become painful and negatively affect ambulation. Most established conservative therapies today target symptomatic relief. As symptoms progress, therapies such as injections, shockwave ablation, radiation, and/or surgery may be required...
January 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29310342/efficacy-and-safety-of-regorafenib-for-advanced-gastrointestinal-stromal-tumor-after-failure-with-imatinib-and-sunitinib-treatment-a-meta-analysis
#4
Zhenan Zhang, Tao Jiang, Wensheng Wang, Daxun Piao
AIMS: This meta-analysis aimed to evaluate the safety and efficacy of regorafenib as a treatment for patients with advanced (metastatic and/or unresectable) gastrointestinal stromal tumor (AGIST) after developing resistance to imatinib and sunitinib. METHODS: A literature search of databases such as PubMed, Embase, and Cochrane library was conducted up to February 2017. The pooled percentages and the corresponding 95% confidence intervals (CIs) were calculated using the Stata 11...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29299198/association-of-the-gene-expression-variation-of-tumor-necrosis-factor-%C3%AE-and-expressions-changes-of-dopamine-receptor-genes-in-progression-of-diabetic-severe-foot-ulcers
#5
Hajar Vaseghi, Majid Pornour, Gholamreza Esmaeeli Djavid, Garshasb Rigi, Shahla Mohammad Ganji, Leila Novin
Objectives: Regulation of pro-inflammatory factors such as TNF-α which are secreted by the immune cells through induction of their several receptors including dopamine receptors (especially DRD2 and DRD3) is one of the noticeable problems in diabetic severe foot ulcer healing. This study was conducted to evaluate the alteration of TNF-αin plasma as well as DRD2 and DRD3 changes in PBMCs of diabetics with severe foot ulcers. Materials and Methods: Peripheral blood samples were collected from 31 subjects with ulcers, 29 without ulcers, and 25 healthy individuals...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29274601/isolated-medial-plantar-neuropathy-caused-by-a-large-ganglion-cyst-diagnosed-with-mri-a-case-report
#6
Shinkyoung Kim, Hyeungjune Kim, Dong In Jo, Sang-Jun Na, Yoon-Sik Jo
INTRODUCTION: Although ganglion cysts are common soft tissue tumors, nerve compression syndrome caused by a ganglion cyst in the lower extremities is very rare. Herein, we report a 57-year-old man who presented with hypoesthesia in the sole of his right foot for 6 months. We believe that reporting this rare case will help clinicians update their knowledge on possible causes of the plantar neuropathy, and avoid diagnostic delay. PRESENTATION OF CASE: The patient had pain and numbness in the inner right sole, as well as a tingling and dull sensation...
December 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29261005/efficacy-and-safety-of-apatinib-monotherapy-in-advanced-bone-and-soft-tissue-sarcoma-an-observational-study
#7
Baorang Zhu, Jing Li, Qiaosheng Xie, Liyan Diao, Lvhua Gai, Wuwei Yang
Sarcomas are rare but malignant tumors with high risks of local recurrence and distant metastasis. Anti-angiogenic therapy is a potential strategy against un-controlled and not-organized tumor angiogenesis. We aimed to assess the safety and efficacy of apatinib, an oral tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, in patients with advanced sarcoma. Thirty-one patients who received initial apatinib between September 2015 and August 2016 were retrospectively reviewed. Among them, 19 (61...
December 20, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29247494/podocyte-and-endothelial-cell-injury-develop-nephrotic-syndrome-in-proliferative-lupus-nephritis
#8
Aya Nawata, Satoshi Hisano, Shohei Shimajiri, Ke-Yong Wang, Yoshiya Tanaka, Toshiyuki Nakayama
AIMS: Nephrotic syndrome (NS) is a major manifestation of lupus nephritis (LN). The dysregulation of podocyte, glomerular basement membrane (GBM) and endothelial cell (EC) develops proteinuria in glomerular diseases. The aim of our study is to clarify whether the dysregulation of these barriers is associated with NS in proliferative LN and membranous LN. METHODS AND RESULTS: Fifty six patients with NS including minimal change NS in 15, primary membranous nephropathy (PMN) in 13, Class III/IV LN in 15 and Class V LN in 13 were enrolled in this study...
December 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29246017/efficacy-and-safety-of-apatinib-combined-with-transarterial-chemoembolization-for-hepatocellular-carcinoma-with-portal-venous-tumor-thrombus-a-retrospective-study
#9
Changfu Liu, Wenge Xing, Tongguo Si, Haipeng Yu, Zhi Guo
Objective: To investigate the efficacy and safety of combined therapy with apatinib and transarterial chemoembolization (TACE) for hepatocellular carcinoma with portal venous tumor thrombus (PVTT). Materials and Methods: We retrospectively analyzed 19 patients with hepatocellular carcinoma with PVTT who were treated with apatinib and TACE at a single center between January 2015 and January 2017. Clinical information on the patients was collected. Adverse events, overall survival, progression-free survival, objective response rate, and disease-control rate based on mRECIST criteria (American Association for the Study of Liver Diseases, 2008) were reviewed and evaluated...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29242789/giant-cell-tumor-of-metacarpal-in-the-skeletally-immature-patient-and-free-osteoarticular-metatarsal-transfer-review-of-literature-with-case-report
#10
Pankaj Kumar Mishra, Yash Agarwal, Prakhar Singhal, Kripa Shankar Mishra
Introduction: In the customary wisdom, it is conceded that giant-cell tumor (GCT) is a pathology of fused epiphysis, but there are literatures available to depict that even though rare bit, but it occurs in the skeletally immature patients. Here, we are presenting a rare case of GCT of the fifth metacarpal in the skeletally immature patient. Case Report: It is a case report of a 13-year-old girl with the history of swelling over her right hand for 5 months. X-ray revealed that there was an osteolytic fusiform expansible lesion...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29240584/dermatofibrosarcoma-protuberans-of-distal-extremities-and-acral-sites-a-clinicopathologic-analysis-of-27-cases
#11
Kabeer K Shah, Jonathan B McHugh, Andrew L Folpe, Rajiv M Patel
Dermatofibrosarcoma protuberans (DFSP) of the distal extremities and acral sites are extremely rare and incompletely characterized. Twenty-seven DFSP occurring in these sites were retrieved from our collective archives and reevaluated. Tumors occurred in 16 males and 11 females. Median age at presentation was 42.5 years (range, 7 to 78 y). Lesions involved the foot (18 with 6 in the toes and 2 on the plantar foot), distal ankle (4), hand (4 with 2 in the thumbs), and wrist (1). All cases showed predominantly classic DFSP morphology and were diffusely CD34 positive...
December 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29231065/serum-interleukin-6-levels-as-an-indicator-of-aseptic-meningitis-among-children-with-enterovirus-71-induced-hand-foot-and-mouth-disease
#12
Joo Young Lee, Minji Son, Jin Han Kang, Ui Yoon Choi
OBJECTIVES: The enterovirus EV71 is a major pathogen of hand, foot, and mouth disease (HFMD) in children. Aseptic meningitis is the most common neurologic complication of EV71-induced HFMD. Lumbar puncture is a crucial procedure in the diagnosis of aseptic meningitis. It is often performed based on physicians' clinical suspicion. A diagnostic method that can aid in deciding whether this procedure should be performed is necessary. Cytokines are speculated to be associated with neurologic complications...
December 14, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/29221662/rare-presentation-of-the-glomus-tumor-in-the-stomach
#13
Maryam Masouminia, Hassan Abdul Ghani, Dingle Foote, Danielle Hari, Samuel French
No abstract text is available yet for this article.
December 5, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29210715/blistering-and-skin-fragility-due-to-imatinib-therapy-loss-of-laminin-and-collagen-iv-as-a-possible-cause-of-cutaneous-basement-membrane-instability
#14
Sebastian Mühl, Jan Ehrchen, Dieter Metze
Imatinib mesylate (Glivec; Novartis AG, Basel, Switzerland) is a tyrosine kinase inhibitor which is used in the treatment of oncologic diseases like chronic myeloid leukemia and gastrointestinal stroma tumor (GIST). Among cutaneous side effects, bullous reactions are rare. The authors describe the case of a 66-year-old woman developing blistering and skin fragility on her hands, foot, lower legs, and back after intake of imatinib for treatment of GIST. Biopsy showed vacuolar alteration at the dermoepidermal junction (DEJ) associated with a few lymphocytes and a subepidermal blister...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29207011/astragaloside-iv-prevents-kidney-injury-caused-by-iatrogenic-hyperinsulinemia-in-a-streptozotocin%C3%A2-induced-diabetic-rat-model
#15
Ke-Qiang He, Wei-Zu Li, Xiao-Qing Chai, Yan-Yan Yin, Yan Jiang, Wei-Ping Li
Diabetic patients are able to manage their blood glucose with exogenous insulin but, ultimately, remain at risk of diabetic nephropathy (DN). Long‑term use of insulin may lead to iatrogenic hyperinsulinemia, which has been suggested to cause kidney injury. However, there are no effective interventions for iatrogenic hyperinsulinemia leading to kidney damage. In the present paper, the hypothesis that astragaloside IV (AS‑IV), a novel saponin purified from Astragalus membranaceus (Fisch) Bunge, may prevent DN in iatrogenic hyperinsulinemic diabetic rats through antioxidative and anti‑inflammatory mechanisms was investigated...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29199537/equine-renal-hemangiosarcoma-clinical-presentation-pathologic-features-and-pstat3-expression
#16
Katherine Hughes, Victoria H L Scott, Maximilian Blanck, Timothy P Barnett, Jannie Spanner Kristiansen, Alastair K Foote
Hemangiosarcoma is an uncommon tumor in horses. We characterized 3 cases of equine renal hemangiosarcoma, focusing on clinical and pathologic features, and describe occurrence of the epithelioid variant of hemangiosarcoma in one of these cases. Nuclear expression of phosphorylated STAT3 (pSTAT3) was assessed to analyze potential inappropriate STAT3 activation as a component of tumor pathogenesis. Clinical signs in the 3 horses included insidious weight loss, followed in one case by serosanguineous nasal discharge and terminal epistaxis, and nonspecific signs of abdominal pain...
December 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29187370/ste20-like-kinase-slk-a-novel-mediator-of-podocyte-integrity
#17
Andrey V Cybulsky, Joan Papillon, Julie Guillemette, Natalya Belkina, Genaro Patino-Lopez, Elena Torban
SLK is essential for embryonic development, and may play a key role in wound healing, tumor growth and metastasis. Expression and activation of SLK is increased in kidney development and during recovery from ischemic acute kidney injury. Overexpression of SLK in glomerular epithelial cells/podocytes in vivo induces injury and proteinuria. Conversely, reduced SLK expression leads to abnormalities in cell adhesion, spreading, and motility. Tight regulation of SLK expression thus may be critical for normal renal structure and function...
November 29, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29184704/surgical-nuances-of-circumferential-lumbar-spondylectomy-a-case-report-and-short-literature-review
#18
Daniel Diaz-Aguilar, Sergei Terterov, Rudi Scharnweber, Harsimran Brara, Alex Tucker, Catherine Merna, Stephanie Wang, Shayan Rahman
Background: Chordomas are uncommon malignant bone tumors that are often minimally symptomatic for several years. By the time they are diagnosed, these lesions are typically large, involve major neural, bony, and vascular structures, and are no longer readily resectable. This leads to a high recurrence rate. Case Description: In this case report, we present a 67-year-old male with nonmechanical axial back pain, neurogenic claudication, and a large mass centered at the L3 level on magnetic resonance imaging consistent with a locally invasive chordoma...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29179501/the-heterogeneous-ctv-ptv-margins-should-be-given-for-different-parts-of-tumors-during-tomotherapy
#19
Ying Tong, Guanzhong Gong, Jinhu Chen, Jie Lu, Tonghai Liu, Pinjing Cheng, Yong Yin
Objective: The purpose of this study was to evaluate CTV-PTV margins of tumors for tomotherapy. Methods: Setup errors were analyzed for 151 patients receiving helical tomotherapy treatment. 53 patients had head and neck tumors, 45 had thoracic tumors, 20 had abdominal tumors, and 33 had pelvic tumors. The setup errors were calculated in six directions, i.e. +X (left), -X (right), +Y (head), -Y (foot), +Z (ventral), and -Z (dorsal), after Megavoltage CT (MVCT) images were registered to simulation CT images...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29173756/proton-therapy-for-head-and-neck-cancers
#20
REVIEW
Pierre Blanchard, Gary Brandon Gunn, Alexander Lin, Robert L Foote, Nancy Y Lee, Steven J Frank
Because of its sharp lateral penumbra and steep distal fall-off, proton therapy offers dosimetric advantages over photon therapy. In head and neck cancer, proton therapy has been used for decades in the treatment of skull-base tumors. In recent years the use of proton therapy has been extended to numerous other disease sites, including nasopharynx, oropharynx, nasal cavity and paranasal sinuses, periorbital tumors, skin, and salivary gland, or to reirradiation. The aim of this review is to present the physical properties and dosimetric benefit of proton therapy over advanced photon therapy; to summarize the clinical benefit described for each disease site; and to discuss issues of patient selection and cost-effectiveness...
January 2018: Seminars in Radiation Oncology
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