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https://www.readbyqxmd.com/read/29760315/structural-differences-in-the-brain-between-wild-and-laboratory-rats-rattus-norvegicus-potential-contribution-to-wariness
#1
Ryoko Koizumi, Yasushi Kiyokawa, Kaori Mikami, Akiko Ishii, Kazuyuki D Tanaka, Tsutomu Tanikawa, Yukari Takeuchi
Wild animals typically exhibit defensive behaviors in response to a wider range and/or a weaker intensity of stimuli compared with domestic animals. However, little is known about the neural mechanisms underlying "wariness" in wild animals. Wild rats are one of the most accessible wild animals for experimental research. Laboratory rats are a domesticated form of wild rat, belonging to the same species, and are therefore considered suitable control animals for wild rats. Based on these factors, we analyzed structural differences in the brain between wild and laboratory rats to elucidate the neural mechanisms underlying wariness...
May 11, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29748055/a-pilot-study-of-bed-nucleus-of-the-stria-terminalis-deep-brain-stimulation-in-treatment-resistant-depression
#2
Paul B Fitzgerald, Rebecca Segrave, Karyn E Richardson, Laura A Knox, Sally Herring, Zafiris J Daskalakis, Richard G Bittar
BACKGROUND: Studies are increasingly investigating the therapeutic effects of deep brain stimulation (DBS) applied to a variety of brain regions in the treatment of patients with highly treatment refractory depression. Limited research to date has investigated the therapeutic potential of DBS applied to the Bed Nucleus Of Stria Terminalis (BNST). OBJECTIVE: The aim of this study was to explore the therapeutic potential of DBS applied to the BNST. METHOD: Five patients with highly treatment resistant depression underwent DBS to the BNST in an open label case series design...
April 23, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29738766/development-of-a-novel-photoaffinity-probe-for-labeling-nocistatin-receptor
#3
Masashi Harada, Toshiaki Minami, Seiji Ito, Emiko Okuda-Ashitaka
Nocistatin (NST) is a neuropeptide produced from the same precursor protein of opioid peptide nociceptin/orphanin FQ (N/OFQ), and it is involved in a broad range of central functions including pain transmission in the nervous system. However, the composition and structure of the receptor(s) for NST remain unclear. Here, we developed NST photoaffinity probe to identify NST-binding receptor. The NST photoaffinity probe contains an azide moiety for the tagging of the binding protein as well as biotin for protein detection...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29704000/glutamatergic-and-gabaergic-ventral-bnst-neurons-differ-in-their-physiological-properties-and-responsiveness-to-noradrenaline
#4
Nur Zeynep Gungor, Ryo Yamamoto, Denis Pare
The bed nucleus of the stria terminalis (BNST) regulates defensive responses to threats and its anteroventral portion (BNST-AV) is involved. BNST-AV contains a minority of glutamatergic neurons scattered among a dominant population of GABAergic cells. There is evidence that these two cell types might exert opposite influences, the former promoting and the latter reducing anxiety. Although GABAergic cells greatly outnumber glutamatergic neurons in BNST-AV, in some circumstances the influence of glutamatergic cells appears to predominate...
April 20, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29679646/chronic-methamphetamine-exposure-attenuates-neural-activation-in-hypothalamic-pituitary-adrenal-axis-associated-brain-regions-in-a-sex-specific-manner
#5
Jason S Jacobskind, Zachary J Rosinger, Tiffany Gonzalez, Kristen L Zuloaga, Damian G Zuloaga
Sex differences in methamphetamine (MA) abuse and consequences of MA have been reported with females showing an increased addiction phenotype and withdrawal symptoms. One mechanism through which these effects might occur is via sex-specific alterations in the hypothalamic-pituitary-adrenal (HPA) axis and its associated brain regions. In this study, mice were administered MA (5 mg/kg) or saline for 10 consecutive days. During early withdrawal, anxiety-like behaviors were assessed in the open field, light/dark box, and elevated plus maze...
April 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29618970/corticotropin-releasing-factor-receptors-modulate-oxytocin-release-in-the-dorsolateral-bed-nucleus-of-the-stria-terminalis-bnst-in-male-rats
#6
Daisy Martinon, Joanna Dabrowska
The neuropeptide oxytocin (OT) plays an important role in the regulation of social and anxiety-like behavior. Our previous studies have shown that OT neurons send projections from the hypothalamus to the dorsolateral bed nucleus of the stria terminalis (BNSTdl ), a forebrain region critically involved in the modulation of anxiety-like behavior. Importantly, these OT terminals in the BNSTdl express presynaptic corticotropin releasing factor (CRF) receptor type 2 (CRFR2). This suggests that CRFR2 might be involved in the modulation of OT release...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29560385/c-fos-mapping-of-brain-regions-activated-by-multi-modal-and-electric-foot-shock-stress
#7
Xiaoxiao Lin, Christy A Itoga, Sharif Taha, Ming H Li, Ryan Chen, Kirolos Sami, Fulvia Berton, Walter Francesconi, Xiangmin Xu
Real-world stressors are complex and multimodal, involving physical, psychological, and social dimensions. However, the brain networks that mediate stress responses to these stimuli need to be further studied. We used c-Fos mapping in mice to characterize brain circuits activated by exposure to a single episode of multimodal stress (MMS), and compared these to circuits activated by electric foot shocks (EFS). We focused on characterizing c-Fos activity in stress-relevant brain regions including the paraventricular nucleus (PVN) of the hypothalamus and the bed nucleus of the stria terminalis (BNST)...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29496632/stereological-analysis-of-microglia-in-aged-male-and-female-fischer-344-rats-in-socially-relevant-brain-regions
#8
Amy E Perkins, Michelle K Piazza, Terrence Deak
Aging is associated with a substantial decline in the expression of social behavior as well as increased neuroinflammation. Since immune activation and subsequent increased expression of cytokines can suppress social behavior in young rodents, we examined age and sex differences in microglia within brain regions critical to social behavior regulation (PVN, BNST, and MEA) as well as in the hippocampus. Adult (3-month) and aged (18-month) male and female F344 (N = 26, n = 5-8/group) rats were perfused and Iba-1 immunopositive microglia were assessed using unbiased stereology and optical density...
May 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29414029/control-of-cardiovascular-responses-to-stress-by-crf-in-the-bed-nucleus-of-stria-terminalis-is-mediated-by-local-nmda-nnos-sgc-pkg-signaling
#9
Leandro A Oliveira, Lucas Gomes-de-Souza, Ricardo Benini, Carlos C Crestani
The aims of the present study were to assess an interaction of corticotropin-releasing factor (CRF) neurotransmission within the bed nucleus of the stria terminalis (BNST) with local nitrergic signaling, as well as to investigate an involvement of activation of local NMDA glutamate receptor and nitric oxide (NO) signaling in control of cardiovascular responses to acute restraint stress by BNST CRF neurotransmission in rats. We observed that CRF microinjection into the BNST increased local NO release during restraint stress...
March 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29408468/neuropeptide-y2-receptors-in-anteroventral-bnst-control-remote-fear-memory-depending-on-extinction-training
#10
Dilip Verma, Ramon Tasan, Guenther Sperk, Hans-Christian Pape
The anterior bed nucleus of stria terminalis (BNST) is involved in reinstatement of extinguished fear, and neuropeptide Y2 receptors influence local synaptic signaling. Therefore, we hypothesized that Y2 receptors in anteroventral BNST (BNSTav) interfere with remote fear memory and that previous fear extinction is an important variable. C57BL/6NCrl mice were fear-conditioned, and a Y2 receptor-specific agonist (NPY3-36 ) or antagonist (JNJ-5207787) was applied in BNSTav before fear retrieval at the following day...
March 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29382815/extended-amygdala-connectivity-changes-during-sustained-shock-anticipation
#11
REVIEW
Salvatore Torrisi, Adam X Gorka, Javier Gonzalez-Castillo, Katherine O'Connell, Nicholas Balderston, Christian Grillon, Monique Ernst
The bed nucleus of the stria terminalis (BNST) and central amygdala (CeA) of the extended amygdala are small, anatomically interconnected brain regions. They are thought to mediate responses to sustained, unpredictable threat stimuli and phasic, predictable threat stimuli, respectively. They perform these operations largely through their interconnected networks. In two previous studies, we mapped and contrasted the resting functional connectivity networks of the BNST and CeA at 7 Tesla with high resolution...
January 31, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29352998/two-weeks-of-variable-stress-increases-gamma-h2ax-levels-in-the-mouse-bed-nucleus-of-the-stria-terminalis
#12
Brendan D Hare, Tina M Thornton, Mercedes Rincon, Borivoj Golijanin, S Bradley King, Diane M Jaworski, William A Falls
Recent reports demonstrate that DNA damage is induced, and rapidly repaired, in circuits activated by experience. Moreover, stress hormones are known to slow DNA repair, suggesting that prolonged stress may result in persistent DNA damage. Prolonged stress is known to negatively impact physical and mental health; however, DNA damage as a factor in stress pathology has only begun to be explored. Histone H2A-X phosphorylated at serine 139 (γH2AX) is a marker of DNA double-strand breaks (DSB), a type of damage that may lead to cell death if unrepaired...
March 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29351398/visceral-hypersensitivity-induced-by-optogenetic-activation-of-the-amygdala-in-conscious-rats
#13
Anthony C Johnson, Rocco Latorre, Casey O Ligon, Beverley Greenwood-Van Meerveld
In vivo optogenetics identifies brain circuits controlling behaviors in conscious animals by using light to alter neuronal function and offers a novel tool to study the brain-gut axis. Using adenoviral-mediated expression, we aimed to investigate whether photoactivation with channelrhodopsin (ChR2) or photoinhibition with halorhodopsin (HR3.0) of fibers originating from the central nucleus of the amygdala (CeA) at the bed nucleus of the stria terminalis (BNST) had any effect on colonic sensitivity. We also investigated whether there was any deleterious effect of the adenovirus on the neuronal population or the neuronal phenotype within the CeA-BNST circuitry activated during the optogenetic stimulation...
March 1, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29330137/the-intersection-of-stress-and-reward-bnst-modulation-of-aversive-and-appetitive-states
#14
REVIEW
Sarah Ch'ng, Jingjing Fu, Robyn M Brown, Stuart J McDougall, Andrew J Lawrence
The bed nucleus of the stria terminalis (BNST) is widely acknowledged as a brain structure that regulates stress and anxiety states, as well as aversive and appetitive behaviours. The diverse roles of the BNST are afforded by its highly modular organisation, neurochemical heterogeneity, and complex intrinsic and extrinsic circuitry. There has been growing interest in the BNST in relation to psychopathologies such as anxiety and addiction. Although research on the human BNST is still in its infancy, there have been extensive preclinical studies examining the molecular signature and hodology of the BNST and their involvement in stress and reward seeking behaviour...
January 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29296027/metabolic-mapping-of-downstream-network-activity-following-cno-induced-activation-of-hm3dq-in-bnst-vgat-neurons
#15
C M Mazzone, D Pati, M Michaelides, J DiBerto, J H Fox, G Tipton, C Anderson, K Duffy, J M McKlveen, J A Hardaway, S T Magness, W A Falls, S E Hammack, Z A McElligott, Y L Hurd, T L Kash
No abstract text is available yet for this article.
January 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29274445/acute-effects-of-electrical-stimulation-of-the-bed-nucleus-of-the-stria-terminalis-internal-capsule-in-obsessive-compulsive-disorder
#16
Lotta Winter, Ivo Heitland, Assel Saryyeva, Götz Lütjens, Kerstin Schwabe, Hans E Heissler, Mesbah Alam, Kai G Kahl, Joachim K Krauss
BACKGROUND: Deep brain stimulation (DBS) has been introduced as a treatment option for treatment-resistant obsessive-compulsive disorder (OCD). However, the optimal stimulation target and the corresponding stimulation settings remain unclear. Furthermore, there is limited knowledge about the acute effects of DBS. METHODS: In 3 patients with treatment-resistant OCD, DBS electrodes were implanted in the bed nucleus of the stria terminalis (BNST)/internal capsule (IC)...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29221794/glp-1-action-in-the-mouse-bed-nucleus-of-the-stria-terminalis
#17
Diana L Williams, Nicole A Lilly, Ian J Edwards, Pallas Yao, James E Richards, Stefan Trapp
Glucagon-like peptide-1 (GLP-1) injected into the brain reduces food intake. Similarly, activation of preproglucagon (PPG) cells in the hindbrain which synthesize GLP-1, reduces food intake. However, it is far from clear whether this happens because of satiety, nausea, reduced reward, or even stress. Here we explore the role of the bed nucleus of the stria terminalis (BNST), an area involved in feeding control as well as stress responses, in GLP-1 responses. Using cre-expressing mice we visualized projections of NTS PPG neurons and GLP-1R-expressing BNST cells with AAV-driven Channelrhodopsin-YFP expression...
March 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29205599/postnatal-separation-prevents-the-development-of-prenatal-stress-induced-anxiety-in-association-with-changes-in-oestrogen-receptor-and-oxytocin-immunoreactivity-in-female-mandarin-vole-microtus-mandarinus-offspring
#18
Fengqin He, Zijian Wang, Guanlin Guo
Oestrogen has both anxiogenic and anxiolytic effects because of variation in opposing action on alpha (ERα) and beta (ERβ) estrogen receptors in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST) and medial amygdala (MeA). Oxytocin (OT) reverses some of the anxiogenic effects of oestrogen in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). Because anxiety disorders are twice as common in women as in men, and oestrogen and OT are more important in females, we examined interactions between prenatal restraint stress (GS) and postnatal early short-term maternal separation (MS) and female mandarin vole behaviour, estrogen receptors and OT...
January 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29177631/manipulating-an-internal-pulse-generator-until-twiddler-s-syndrome-in-a-patient-treated-with-deep-brain-stimulation-for-obsessive-compulsive-disorder
#19
Andrea Franzini, Rebecca Ranieri, Orsola Gambini, Giuseppe Messina
BACKGROUND: Twiddler's syndrome consists of rotation or manipulation of an implantable pulse generator (IPG) in its subcutaneous pocket by a patient, thus causing hardware malfunction. METHODS: This syndrome is being reported more frequently in patients treated with deep brain stimulation (DBS). RESULTS: We report the case of a woman who had received bed nucleus of stria terminalis (BNST) electrodes for obsessive-compulsive disorder (OCD) and developed twiddler's syndrome a few months after surgery, causing hardware malfunction due to obsessive manipulation of the IPG...
February 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29169825/nitric-oxide-cgmp-pkg-signaling-in-the-bed-nucleus-of-the-stria-terminalis-modulates-the-cardiovascular-responses-to-stress-in-male-rats
#20
Lucas Barretto-de-Souza, Mariane B Adami, Leandro A Oliveira, Lucas Gomes-de-Souza, Josiane O Duarte, Jeferson Almeida, Carlos C Crestani
The bed nucleus of the stria terminalis (BNST) constitutes an important component of neural substrates of physiological and behavioral responses to aversive stimuli, and it has been implicated on cardiovascular responses evoked by stress. Nevertheless, the local neurochemical mechanisms involved in BNST control of cardiovascular responses during aversive threats are still poorly understood. Thus, the aim of the present study was to assess the involvement of activation in the BNST of the neuronal isoform of the enzyme nitric oxide synthase (nNOS), as well as of signaling mechanisms related to nitric oxide effects such as soluble guanylate cyclase (sGC) and protein kinase G (PKG) on cardiovascular responses induced by an acute session of restraint stress in male rats...
January 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
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