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https://www.readbyqxmd.com/read/28539954/differential-histone-acetylation-in-sub-regions-of-bed-nucleus-of-the-stria-terminalis-underlies-fear-consolidation-and-extinction
#1
Vandana Ranjan, Sanjay Singh, Sarfraj Ahmad Siddiqui, Sukanya Tripathi, Mohd Yahiya Khan, Anand Prakash
OBJECTIVE: The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control the fear learning process. However the exact mechanism how the BNST controls fear consolidation and its extinction is largely unknown. In the present study we observed the changes in the BNST sub-regions following fear conditioning and its extinction. METHODS: The change in the number of positive neurons was determined by immunohistochemistry for Acetyl H3 (Histone 3), Acetyl H4 (Histone 4), cAMP response element binding Protein (CBP) and c-fos in three sub-regions of the BNST namely the anterio-lateral BNST (STLP) and anterio-medial BNST (STMA), and lateral-ventral BNST (STLV) of rats subjected to auditory fear conditioning and extinction...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28522214/p2-purinergic-receptor-antagonists-disrupt-maternal-behavior-in-lactating-rats
#2
Luciana C Teodoro, Layla D M Cabral, Fabiana C Vilela, Alexandre Giusti-Paiva
The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems. Therefore, the aim of our study was to investigate whether central administration of P2 receptor antagonists affected the maternal behavior of lactating rats and c-Fos immunoreactivity in the forebrain. On day 7 of lactation, female rats were treated with vehicle (5μL; i...
May 15, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28502843/disentangling-the-effects-of-novelty-valence-and-trait-anxiety-in-the-bed-nucleus-of-the-stria-terminalis-amygdala-and-hippocampus-with-high-resolution-7t-fmri
#3
Walker S Pedersen, L Tugan Muftuler, Christine L Larson
The hippocampus and amygdala exhibit sensitivity to stimulus novelty that is reduced in participants with inhibited temperament, which is related to trait anxiety. Although the bed nucleus of the stria terminalis (BNST) is highly connected to the amygdala and is implicated in anxiety, whether the BNST responds to novelty remains unstudied, as well as how trait anxiety may modulate this response. Additionally how novelty, stimulus negativity and trait anxiety interact to affect activity in these areas is also unclear...
May 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/28485259/distinct-phasic-and-sustained-brain-responses-and-connectivity-of-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-panic-disorder
#4
L Brinkmann, C Buff, K Feldker, S V Tupak, M P I Becker, M J Herrmann, T Straube
BACKGROUND: Panic disorder (PD) patients are constantly concerned about future panic attacks and exhibit general hypersensitivity to unpredictable threat. We aimed to reveal phasic and sustained brain responses and functional connectivity of the amygdala and the bed nucleus of the stria terminalis (BNST) during threat anticipation in PD. METHODS: Using functional magnetic resonance imaging (fMRI), we investigated 17 PD patients and 19 healthy controls (HC) during anticipation of temporally unpredictable aversive and neutral sounds...
May 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28419831/molecular-phenotyping-of-transient-postnatal-tyrosine-hydroxylase-neurons-in-the-rat-bed-nucleus-of-the-stria-terminalis
#5
David A Carter
The bed nucleus of the stria terminalis (BNST) is a complex integrative centre in the forebrain, composed of multiple sub-nuclei, each with discrete populations of neurons. Progress in understanding BNST function, both in the adult and during postnatal maturation, is dependent upon a more complete characterization of neuronal phenotypes in the BNST. The aim of the current study was to define the molecular phenotype of one postnatal BNST neuronal population, in order to identify molecular factors that may underlie both (protein marker-related) immaturity, and secondly, the transience of this phenotype...
April 15, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28396628/moxd1-is-a-marker-for-sexual-dimorphism-in-the-medial-preoptic-area-bed-nucleus-of-the-stria-terminalis-and-medial-amygdala
#6
Yousuke Tsuneoka, Shinji Tsukahara, Sachine Yoshida, Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
The brain shows various sex differences in its structures. Various mammalian species exhibit sex differences in the sexually dimorphic nucleus of the preoptic area (SDN-POA) and parts of the extended amygdala such as the principal nucleus of the bed nucleus of the stria terminalis (BNSTpr) and posterodorsal part of the medial amygdala (MePD). The SDN-POA and BNSTpr are male-biased sexually dimorphic nuclei, and characterized by the expression of calbindin D-28K (calbindin 1). However, calbindin-immunoreactive cells are not restricted to the SDN-POA, but widely distributed outside of the SDN-POA...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28392491/intrinsic-functional-connectivity-of-the-central-nucleus-of-the-amygdala-and-bed-nucleus-of-the-stria-terminalis
#7
Adam X Gorka, Salvatore Torrisi, Alexander J Shackman, Christian Grillon, Monique Ernst
The central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST), two nuclei within the central extended amygdala, function as critical relays within the distributed neural networks that coordinate sensory, emotional, and cognitive responses to threat. These structures have overlapping anatomical projections to downstream targets that initiate defensive responses. Despite these commonalities, researchers have also proposed a functional dissociation between the CeA and BNST, with the CeA promoting responses to discrete stimuli and the BNST promoting responses to diffuse threat...
April 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28392296/anxious-behavior-induces-elevated-hippocampal-cb2-receptor-gene-expression
#8
James M Robertson, Justin K Achua, Justin P Smith, Melissa A Prince, Clarissa D Staton, Patrick J Ronan, Tangi R Summers, Cliff H Summers
Anxiety is differentially expressed across a continuum of stressful/fearful intensity, influenced by endocannabinoid systems and receptors. The hippocampus plays important roles in the regulation of affective behavior, emotion, and anxiety, as well as memory. Location of Cb1/Cb2 receptor action could be important in determining emotional valence, because while the dorsal hippocampus is involved in spatial memory and cognition, the ventral hippocampus has projections to the PFC, BNST, amygdala, and HPA axis, and is important for emotional responses to stress...
June 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28359742/increased-vasopressin-expression-in-the-bnst-accompanies-paternally-induced-territoriality-in-male-and-female-california-mouse-offspring
#9
Christine N Yohn, Amanda B Leithead, Elizabeth A Becker
While developmental consequences of parental investment on species-typical social behaviors has been extensively characterized in same-sex parent-offspring interactions, the impact of opposite-sex relationships is less clear. In the bi-parental California mouse (Peromyscus californicus), paternal retrieval behavior induces territorial aggression and the expression of arginine vasopressin (AVP) in adult male offspring. Although similar patterns of territorially emerge among females, the sexually dimorphic AVP system has not been considered since it is generally thought to regulate male-typical behavior...
April 24, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28351600/the-bed-nucleus-of-the-stria-terminalis-in-drug-associated-behavior-and-affect-a-circuit-based-perspective
#10
REVIEW
Oliver Vranjkovic, Melanie Pina, Thomas L Kash, Danny G Winder
The bed nucleus of the stria terminalis was first described nearly a century ago and has since emerged as a region central to motivated behavior and affective states. The last several decades have firmly established a role for the BNST in drug-associated behavior and implicated this region in addiction-related processes. Whereas past approaches used to characterize the BNST have focused on a more general role of this region and its subnuclei in behavior, more recent work has begun to reveal its elaborate circuitry and cellular components...
March 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28295315/a-comparative-analysis-of-the-physiological-properties-of-neurons-in-the-anterolateral-bed-nucleus-of-the-stria-terminalis-in-the-mus-musculus-rattus-norvegicus-and-macaca-mulatta
#11
Sarah E Daniel, Jidong Guo, Donald G Rainnie
The anterolateral group of the bed nucleus of the stria terminalis (BNSTALG ) is a critical modulator of a variety of rodent and primate behaviors spanning anxiety behavior and drug addiction. Three distinct neuronal cell types have been previously defined in the rat BNSTALG based on differences in the voltage-response to hyperpolarizing and depolarizing current injection. Differences in genetic expression profile between these three cell types suggest electrophysiological cell type may be an indicator for functional differences in the circuit of the rat BNSTALG ...
March 13, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28263413/species-specific-diversity-in-the-anatomical-and-physiological-organisation-of-the-bnst-vta-pathway
#12
Jennifer Kaufling, Delphine Girard, Marlène Maitre, Thierry Leste-Lasserre, François Georges
The anteromedial part of the bed nucleus of the stria terminalis (amBNST) is a limbic structure innervating the ventral tegmental area (VTA) that is remarkably constant across species. The amBNST modulates fear and anxiety, and activation of VTA dopamine (DA) neurons by amBNST afferents seems to be the way by which stress controls motivational states associated with reward or aversion. Because fear learning and anxiety states can be expressed differently between rats and mice, we compared the functional connectivity between amBNST and the VTA-DA neurons in both species using consistent methodological approaches...
March 6, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28230907/estrogenic-suppression-of-binge-like-eating-elicited-by-cyclic-food-restriction-and-frustrative-nonreward-stress-in-female-rats
#13
Maria Vittoria Micioni Di Bonaventura, Thomas A Lutz, Adele Romano, Mariangela Pucci, Nori Geary, Lori Asarian, Carlo Cifani
Because binge eating and emotional eating vary through the menstrual cycle in human females, we investigated cyclic changes in binge-like eating in female rats and their control by estrogens. Binge-like eating was elicited by three cycles of 4 days of food restriction and 4 days of free feeding followed by a single frustrative nonreward-stress episode (15 min visual and olfactory exposure to a familiar palatable food) immediately before presentation of the palatable food. Intact rats showed binge-like eating during the diestrous and proestrous phases of the ovarian cycle, but not during the estrous (periovulatory) phase...
February 23, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28218243/nmda-receptor-dependent-plasticity-in-the-bed-nucleus-of-the-stria-terminalis-triggers-long-term-anxiolysis
#14
Christelle Glangetas, Léma Massi, Giulia R Fois, Marion Jalabert, Delphine Girard, Marco Diana, Keisuke Yonehara, Botond Roska, Chun Xu, Andreas Lüthi, Stéphanie Caille, François Georges
Anxiety is controlled by multiple neuronal circuits that share robust and reciprocal connections with the bed nucleus of the stria terminalis (BNST), a key structure controlling negative emotional states. However, it remains unknown how the BNST integrates diverse inputs to modulate anxiety. In this study, we evaluated the contribution of infralimbic cortex (ILCx) and ventral subiculum/CA1 (vSUB/CA1) inputs in regulating BNST activity at the single-cell level. Using trans-synaptic tracing from single-electroporated neurons and in vivo recordings, we show that vSUB/CA1 stimulation promotes opposite forms of in vivo plasticity at the single-cell level in the anteromedial part of the BNST (amBNST)...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28198211/both-n-methyl-d-aspartate-and-non-n-methyl-d-aspartate-glutamate-receptors-in-the-bed-nucleus-of-the-stria-terminalis-modulate-the-cardiovascular-responses-to-acute-restraint-stress-in-rats
#15
Mariane B Adami, Lucas Barretto-de-Souza, Josiane O Duarte, Jeferson Almeida, Carlos C Crestani
The bed nucleus of the stria terminalis (BNST) is a forebrain structure that has been implicated on cardiovascular responses evoked by emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully described. In our study we investigated the involvement of glutamatergic neurotransmission within the BNST in cardiovascular changes evoked by acute restraint stress in rats. For this study, we investigated the effects of bilateral microinjections of selective antagonists of either N-methyl-D-aspartate (NMDA) or non-NMDA glutamate receptors into the BNST on the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by acute restraint stress...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28115236/decrease-in-neuronal-spine-density-in-the-postpartum-period-in-the-amygdala-and-bed-nucleus-of-the-stria-terminalis-in-rat
#16
Seiki Matsuo, Ken Ichi Matsuda, Keiko Takanami, Taisuke Mori, Masaki Tanaka, Mitsuhiro Kawata, Jo Kitawaki
In pregnancy and the postpartum period, many women have emotional instability and some suffer from depression. The ovarian steroid hormone milieu is markedly changed during these periods, and this hormonal change may be an important cause of peripartum emotional instability. The amygdala is a central region of emotion, and the bed nucleus of the stria terminalis (BNST), which is considered to be the extended amygdala, is also involved in the emotional response. The amygdala and BNST are well characterized as target brain regions for ovarian steroid hormones, and this suggests that the functional response of neurons in these regions to hormonal fluctuation is affected in the peripartum period...
January 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28108394/unsmoothed-functional-mri-of-the-human-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-processing-of-emotional-faces
#17
Ronald Sladky, Nicole Geissberger, Daniela M Pfabigan, Christoph Kraus, Martin Tik, Michael Woletz, Katharina Paul, Thomas Vanicek, Bastian Auer, Georg S Kranz, Claus Lamm, Rupert Lanzenberger, Christian Windischberger
Functional neuroimaging of the human amygdala has been of great interest to uncover the neural underpinnings of emotions, mood, motivation, social cognition, and decision making, as well as their dysfunction in psychiatric disorders. Yet, several factors limit in vivo imaging of amygdalar function, most importantly its location deep within the temporal lobe adjacent to air-filled cavities that cause magnetic field inhomogeneities entailing signal dropouts. Additionally, the amygdala and the extended amygdalar region consist of several substructures, which have been assigned different functions and have important implications for functional and effective connectivity studies...
January 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28106040/the-effects-of-prior-stress-on-anxiety-like-responding-to-intra-bnst-pituitary-adenylate-cyclase-activating-polypeptide-in-male-and-female-rats
#18
S Bradley King, Kim R Lezak, Micaela O'Reilly, Donna J Toufexis, William A Falls, Karen Braas, Victor May, Sayamwong E Hammack
Chronic or repeated exposure to stressful stimuli can result in several maladaptive consequences, including increased anxiety-like behaviors and altered peptide expression in anxiety-related brain structures. Among these structures, the bed nucleus of the stria terminalis (BNST) has been implicated in emotional behaviors as well as regulation of hypothalamic-pituitary-adrenal (HPA) axis activity. In male rodents, chronic variate stress (CVS) has been shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate PAC1 receptor transcript, and BNST PACAP signaling may mediate the maladaptive changes associated with chronic stress...
February 15, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28104355/allopregnanolone-induces-state-dependent-fear-via-the-bed-nucleus-of-the-stria-terminalis
#19
Gillian M Acca, Abel S Mathew, Jingji Jin, Stephen Maren, Naomi Nagaya
Gonadal steroids and their metabolites have been shown to be important modulators of emotional behavior. Allopregnanolone (ALLO), for example, is a metabolite of progesterone that has been linked to anxiety-related disorders such as posttraumatic stress disorder. In rodents, it has been shown to reduce anxiety in a number of behavioral paradigms including Pavlovian fear conditioning. We have recently found that expression of conditioned contextual (but not auditory) freezing in rats can be suppressed by infusion of ALLO into the bed nucleus of the stria terminalis (BNST)...
March 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28070973/dissociation-between-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-female-post-traumatic-stress-disorder-patients
#20
Leonie Brinkmann, Christine Buff, Paula Neumeister, Sara V Tupak, Michael P I Becker, Martin J Herrmann, Thomas Straube
Feelings of uncontrollability and anxiety regarding possibly harmful events are key features of post-traumatic stress disorder (PTSD) symptomatology. Due to a lack of studies, the neural correlates of anticipatory anxiety in PTSD are still poorly understood. During functional magnetic resonance imaging, female PTSD patients with interpersonal violence trauma and healthy controls (HC) anticipated the temporally unpredictable presentation of aversive (human scream) or neutral sounds. Based on separate analysis models, we investigated phasic and sustained brain activations...
January 10, 2017: Human Brain Mapping
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