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https://www.readbyqxmd.com/read/28419831/molecular-phenotyping-of-transient-postnatal-tyrosine-hydroxylase-neurons-in-the-rat-bed-nucleus-of-the-stria-terminalis
#1
David A Carter
The bed nucleus of the stria terminalis (BNST) is a complex integrative centre in the forebrain, composed of multiple sub-nuclei, each with discrete populations of neurons. Progress in understanding BNST function, both in the adult and during postnatal maturation, is dependent upon a more complete characterization of neuronal phenotypes in the BNST. The aim of the current study was to define the molecular phenotype of one postnatal BNST neuronal population, in order to identify molecular factors that may underlie both (protein marker-related) immaturity, and secondly, the transience of this phenotype...
April 15, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28396628/moxd1-is-a-marker-for-sexual-dimorphism-in-the-medial-preoptic-area-bed-nucleus-of-the-stria-terminalis-and-medial-amygdala
#2
Yousuke Tsuneoka, Shinji Tsukahara, Sachine Yoshida, Kenkichi Takase, Satoko Oda, Masaru Kuroda, Hiromasa Funato
The brain shows various sex differences in its structures. Various mammalian species exhibit sex differences in the sexually dimorphic nucleus of the preoptic area (SDN-POA) and parts of the extended amygdala such as the principal nucleus of the bed nucleus of the stria terminalis (BNSTpr) and posterodorsal part of the medial amygdala (MePD). The SDN-POA and BNSTpr are male-biased sexually dimorphic nuclei, and characterized by the expression of calbindin D-28K (calbindin 1). However, calbindin-immunoreactive cells are not restricted to the SDN-POA, but widely distributed outside of the SDN-POA...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28392491/intrinsic-functional-connectivity-of-the-central-nucleus-of-the-amygdala-and-bed-nucleus-of-the-stria-terminalis
#3
Adam X Gorka, Salvatore Torrisi, Alexander J Shackman, Christian Grillon, Monique Ernst
The central nucleus of the amygdala (CeA) and bed nucleus of the stria terminalis (BNST), two nuclei within the central extended amygdala, function as critical relays within the distributed neural networks that coordinate sensory, emotional, and cognitive responses to threat. These structures have overlapping anatomical projections to downstream targets that initiate defensive responses. Despite these commonalities, researchers have also proposed a functional dissociation between the CeA and BNST, with the CeA promoting responses to discrete stimuli and the BNST promoting responses to diffuse threat...
April 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28392296/anxious-behavior-induces-elevated-hippocampal-cb2-receptor-gene-expression
#4
James M Robertson, Justin K Achua, Justin P Smith, Melissa A Prince, Clarissa D Staton, Patrick J Ronan, Tangi R Summers, Cliff H Summers
Anxiety is differentially expressed across a continuum of stressful/fearful intensity, influenced endocannabinoid systems and receptors. The hippocampus plays important roles in the regulation of affective behavior, emotion, and anxiety, as well as memory. Location of Cb1/Cb2 receptor action could be important in determining emotional valence, because while the dorsal hippocampus is involved in spatial memory and cognition, the ventral hippocampus has projections to the PFC, BNST, amygdala, and HPA axis, and is important for emotional responses to stress...
April 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28359742/increased-vasopressin-expression-in-the-bnst-accompanies-paternally-induced-territoriality-in-male-and-female-california-mouse-offspring
#5
Christine N Yohn, Amanda B Leithead, Elizabeth A Becker
While developmental consequences of parental investment on species-typical social behaviors has been extensively characterized in same-sex parent-offspring interactions, the impact of opposite-sex relationships is less clear. In the bi-parental California mouse (Peromyscus californicus), paternal retrieval behavior induces territorial aggression and the expression of arginine vasopressin (AVP) in adult male offspring. Although similar patterns of territorially emerge among females, the sexually dimorphic AVP system has not been considered since it is generally thought to regulate male-typical behavior...
March 27, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28351600/the-bed-nucleus-of-the-stria-terminalis-in-drug-associated-behavior-and-affect-a-circuit-based-perspective
#6
REVIEW
Oliver Vranjkovic, Melanie Pina, Thomas L Kash, Danny G Winder
The bed nucleus of the stria terminalis was first described nearly a century ago and has since emerged as a region central to motivated behavior and affective states. The last several decades have firmly established a role for the BNST in drug-associated behavior and implicated this region in addiction-related processes. Whereas past approaches used to characterize the BNST have focused on a more general role of this region and its subnuclei in behavior, more recent work has begun to reveal its elaborate circuitry and cellular components...
March 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28295315/a-comparative-analysis-of-the-physiological-properties-of-neurons-in-the-anterolateral-bed-nucleus-of-the-stria-terminalis-in-the-mus-musculus-rattus-norvegicus-and-macaca-mulatta
#7
Sarah E Daniel, Jidong Guo, Donald G Rainnie
The anterolateral group of the bed nucleus of the stria terminalis (BNSTALG ) is a critical modulator of a variety of rodent and primate behaviors spanning anxiety behavior and drug addiction. Three distinct neuronal cell types have been previously defined in the rat BNSTALG based on differences in the voltage-response to hyperpolarizing and depolarizing current injection. Differences in genetic expression profile between these three cell types suggest electrophysiological cell type may be an indicator for functional differences in the circuit of the rat BNSTALG ...
March 13, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28263413/species-specific-diversity-in-the-anatomical-and-physiological-organization-of-the-bnst-vta-pathway
#8
Jennifer Kaufling, Delphine Girard, Marlène Maitre, Thierry Leste-Lasserre, François Georges
The anteromedial part of the bed nucleus of the stria terminalis (amBNST) is a limbic structure innervating the ventral tegmental area (VTA) that is remarkably constant across species. The amBNST modulates fear and anxiety, and activation of VTA dopamine (DA) neurons by amBNST afferents seems to be the way by which stress controls motivational states associated with reward or aversion. Because fear learning and anxiety states can be expressed differently between rats and mice, we compared the functional connectivity between amBNST and the VTA-DA neurons in both species using consistant methodological approaches...
March 6, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28230907/estrogenic-suppression-of-binge-like-eating-elicited-by-cyclic-food-restriction-and-frustrative-nonreward-stress-in-female-rats
#9
Maria Vittoria Micioni Di Bonaventura, Thomas A Lutz, Adele Romano, Mariangela Pucci, Nori Geary, Lori Asarian, Carlo Cifani
Because binge eating and emotional eating vary through the menstrual cycle in human females, we investigated cyclic changes in binge-like eating in female rats and their control by estrogens. Binge-like eating was elicited by three cycles of 4 days of food restriction and 4 days of free feeding followed by a single frustrative nonreward-stress episode (15 min visual and olfactory exposure to a familiar palatable food) immediately before presentation of the palatable food. Intact rats showed binge-like eating during the diestrous and proestrous phases of the ovarian cycle, but not during the estrous (periovulatory) phase...
February 23, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28218243/nmda-receptor-dependent-plasticity-in-the-bed-nucleus-of-the-stria-terminalis-triggers-long-term-anxiolysis
#10
Christelle Glangetas, Léma Massi, Giulia R Fois, Marion Jalabert, Delphine Girard, Marco Diana, Keisuke Yonehara, Botond Roska, Chun Xu, Andreas Lüthi, Stéphanie Caille, François Georges
Anxiety is controlled by multiple neuronal circuits that share robust and reciprocal connections with the bed nucleus of the stria terminalis (BNST), a key structure controlling negative emotional states. However, it remains unknown how the BNST integrates diverse inputs to modulate anxiety. In this study, we evaluated the contribution of infralimbic cortex (ILCx) and ventral subiculum/CA1 (vSUB/CA1) inputs in regulating BNST activity at the single-cell level. Using trans-synaptic tracing from single-electroporated neurons and in vivo recordings, we show that vSUB/CA1 stimulation promotes opposite forms of in vivo plasticity at the single-cell level in the anteromedial part of the BNST (amBNST)...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28198211/both-n-methyl-d-aspartate-and-non-n-methyl-d-aspartate-glutamate-receptors-in-the-bed-nucleus-of-the-stria-terminalis-modulate-the-cardiovascular-responses-to-acute-restraint-stress-in-rats
#11
Mariane B Adami, Lucas Barretto-de-Souza, Josiane O Duarte, Jeferson Almeida, Carlos C Crestani
The bed nucleus of the stria terminalis (BNST) is a forebrain structure that has been implicated on cardiovascular responses evoked by emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully described. In our study we investigated the involvement of glutamatergic neurotransmission within the BNST in cardiovascular changes evoked by acute restraint stress in rats. For this study, we investigated the effects of bilateral microinjections of selective antagonists of either N-methyl-D-aspartate (NMDA) or non-NMDA glutamate receptors into the BNST on the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by acute restraint stress...
February 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28115236/decrease-in-neuronal-spine-density-in-the-postpartum-period-in-the-amygdala-and-bed-nucleus-of-the-stria-terminalis-in-rat
#12
Seiki Matsuo, Ken Ichi Matsuda, Keiko Takanami, Taisuke Mori, Masaki Tanaka, Mitsuhiro Kawata, Jo Kitawaki
In pregnancy and the postpartum period, many women have emotional instability and some suffer from depression. The ovarian steroid hormone milieu is markedly changed during these periods, and this hormonal change may be an important cause of peripartum emotional instability. The amygdala is a central region of emotion, and the bed nucleus of the stria terminalis (BNST), which is considered to be the extended amygdala, is also involved in the emotional response. The amygdala and BNST are well characterized as target brain regions for ovarian steroid hormones, and this suggests that the functional response of neurons in these regions to hormonal fluctuation is affected in the peripartum period...
January 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28108394/unsmoothed-functional-mri-of-the-human-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-processing-of-emotional-faces
#13
Ronald Sladky, Nicole Geissberger, Daniela M Pfabigan, Christoph Kraus, Martin Tik, Michael Woletz, Katharina Paul, Thomas Vanicek, Bastian Auer, Georg S Kranz, Claus Lamm, Rupert Lanzenberger, Christian Windischberger
Functional neuroimaging of the human amygdala has been of great interest to uncover the neural underpinnings of emotions, mood, motivation, social cognition, and decision making, as well as their dysfunction in psychiatric disorders. Yet, several factors limit in vivo imaging of amygdalar function, most importantly its location deep within the temporal lobe adjacent to air-filled cavities that cause magnetic field inhomogeneities entailing signal dropouts. Additionally, the amygdala and the extended amygdalar region consist of several substructures, which have been assigned different functions and have important implications for functional and effective connectivity studies...
January 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28106040/the-effects-of-prior-stress-on-anxiety-like-responding-to-intra-bnst-pituitary-adenylate-cyclase-activating-polypeptide-pacap-in-male-and-female-rats
#14
S Bradley King, Kim R Lezak, Micaela O'Reilly, Donna J Toufexis, William A Falls, Karen Braas, Victor May, Sayamwong E Hammack
Chronic or repeated exposure to stressful stimuli can result in several maladaptive consequences, including increased anxiety-like behaviors and altered peptide expression in anxiety-related brain structures. Among these structures, the bed nucleus of the stria terminalis (BNST) has been implicated in emotional behaviors as well as regulation of hypothalamic-pituitary-adrenal (HPA) axis activity. In male rodents, chronic variate stress (CVS) has been shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its cognate PAC1 receptor transcript, and BNST PACAP signaling may mediate the maladaptive changes associated with chronic stress...
January 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28104355/allopregnanolone-induces-state-dependent-fear-via-the-bed-nucleus-of-the-stria-terminalis
#15
Gillian M Acca, Abel S Mathew, Jingji Jin, Stephen Maren, Naomi Nagaya
Gonadal steroids and their metabolites have been shown to be important modulators of emotional behavior. Allopregnanolone (ALLO), for example, is a metabolite of progesterone that has been linked to anxiety-related disorders such as posttraumatic stress disorder. In rodents, it has been shown to reduce anxiety in a number of behavioral paradigms including Pavlovian fear conditioning. We have recently found that expression of conditioned contextual (but not auditory) freezing in rats can be suppressed by infusion of ALLO into the bed nucleus of the stria terminalis (BNST)...
March 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28070973/dissociation-between-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-female-post-traumatic-stress-disorder-patients
#16
Leonie Brinkmann, Christine Buff, Paula Neumeister, Sara V Tupak, Michael P I Becker, Martin J Herrmann, Thomas Straube
Feelings of uncontrollability and anxiety regarding possibly harmful events are key features of post-traumatic stress disorder (PTSD) symptomatology. Due to a lack of studies, the neural correlates of anticipatory anxiety in PTSD are still poorly understood. During functional magnetic resonance imaging, female PTSD patients with interpersonal violence trauma and healthy controls (HC) anticipated the temporally unpredictable presentation of aversive (human scream) or neutral sounds. Based on separate analysis models, we investigated phasic and sustained brain activations...
January 10, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28008079/the-effects-of-stimulus-novelty-and-negativity-on-bold-activity-in-the-amygdala-hippocampus-and-bed-nucleus-of-the-stria-terminalis
#17
Walker S Pedersen, Nicholas L Balderston, Tara A Miskovich, Emily L Belleau, Fred J Helmstetter, Christine L Larson
The amygdala responds to stimulus novelty, which may correspond to an evaluation of novel stimuli for potential threat, and trait anxiety may modulate this response. The bed nucleus of the stria terminalis (BNST) may also be sensitive to novelty as it responds to both uncertainty and threat. If so, a BNST novelty response may also be affected by trait anxiety and interact with stimulus negativity. We presented participants with novel and repeated negative and neutral images while measuring brain activity via fMRI, and assessed participants' self-reported trait anxiety...
December 21, 2016: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28007657/aging-and-estradiol-effects-on-gene-expression-in-the-medial-preoptic-area-bed-nucleus-of-the-stria-terminalis-and-posterodorsal-medial-amygdala-of-male-rats
#18
Victoria L Nutsch, Margaret R Bell, Ryan G Will, Weiling Yin, Andrew Wolfe, Ross Gillette, Juan M Dominguez, Andrea C Gore
Studies on the role of hormones in male reproductive aging have traditionally focused on testosterone, but estradiol (E2) also plays important roles in the control of masculine physiology and behavior. Our goal was to examine the effects of E2 on the expression of genes selected for E2-sensitivity, involvement in behavioral neuroendocrine functions, and impairments with aging. Mature adult (MAT, 5 mo) and aged (AG, 18 mo) Sprague-Dawley male rats were castrated, implanted with either vehicle or E2 subcutaneous capsules, and euthanized one month later...
February 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27956747/acute-engagement-of-gq-mediated-signaling-in-the-bed-nucleus-of-the-stria-terminalis-induces-anxiety-like-behavior
#19
C M Mazzone, D Pati, M Michaelides, J DiBerto, J H Fox, G Tipton, C Anderson, K Duffy, J M McKlveen, J A Hardaway, S T Magness, W A Falls, S E Hammack, Z A McElligott, Y L Hurd, T L Kash
The bed nucleus of the stria terminalis (BNST) is a brain region important for regulating anxiety-related behavior in both humans and rodents. Here we used a chemogenetic strategy to investigate how engagement of G protein-coupled receptor (GPCR) signaling cascades in genetically defined GABAergic BNST neurons modulates anxiety-related behavior and downstream circuit function. We saw that stimulation of vesicular γ-aminobutyric acid (GABA) transporter (VGAT)-expressing BNST neurons using hM3Dq, but neither hM4Di nor rM3Ds designer receptors exclusively activated by a designer drug (DREADD), promotes anxiety-like behavior...
December 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27888284/attenuation-of-the-anxiogenic-effects-of-cocaine-by-5-ht1b-autoreceptor-stimulation-in-the-bed-nucleus-of-the-stria-terminalis-of-rats
#20
Adam K Klein, Michael A Brito, Sayeh Akhavan, Dylan R Flanagan, Nikki Le, Tatum Ohana, Anand S Patil, Erin M Purvis, Carl Provenzano, Alex Wei, Lucy Zhou, Aaron Ettenberg
RATIONALE: Cocaine produces significant aversive/anxiogenic actions whose underlying neurobiology remains unclear. A possible substrate contributing to these actions is the serotonergic (5-HT) pathway projecting from the dorsal raphé (DRN) to regions of the extended amygdala, including the bed nucleus of the stria terminalis (BNST) which have been implicated in the production of anxiogenic states. OBJECTIVES: The present study examined the contribution of 5-HT signaling within the BNST to the anxiogenic effects of cocaine as measured in a runway model of drug self-administration...
February 2017: Psychopharmacology
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