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https://www.readbyqxmd.com/read/28921616/tangential-migration-of-corridor-guidepost-neurons-contributes-to-anxiety-circuits
#1
Andrea Tinterri, Marie Deck, Maryama Keita, Caroline Mailhes, Anna Noren Rubin, Nicoletta Kessaris, Ludmilla Lokmane, Franck Bielle, Sonia Garel
In mammals, thalamic axons are guided internally towards their neocortical target by corridor (Co) neurons that act as axonal guideposts. The existence of Co-like neurons in non-mammalian species, in which thalamic axons do not grow internally, raised the possibility that Co cells might have an ancestral role. Here, we investigated the contribution of corridor (Co) cells to mature brain circuits using a combination of genetic fate-mapping and assays in mice. We unexpectedly found that Co neurons contribute to striatal-like projection neurons in the central extended amygdala...
September 18, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28916137/oxytocin-induces-penile-erection-and-yawning-when-injected-into-the-bed-nucleus-of-the-stria-terminalis-involvement-of-glutamic-acid-dopamine-and-nitric-oxide
#2
Fabrizio Sanna, Jessica Bratzu, Antonio Argiolas, Maria Rosaria Melis
Oxytocin (5-100ng), but not Arg(8)-vasopressin (100ng), injected unilaterally into the bed nucleus of the stria terminalis (BNST) induces penile erection and yawning in a dose-dependent manner in male rats. The minimal effective dose was 20ng for penile erection and 5ng for yawning. Oxytocin responses were abolished not only by the oxytocin receptor antagonist d(CH2)5Tyr(Me)(2)-Orn(8)-vasotocin (1μg), but also by (+) MK-801 (1μg), an excitatory amino acid receptor antagonist of the N-methyl-d-aspartic acid (NMDA) subtype, SCH 23390 (1μg), a D1 receptor antagonist, but not haloperidol (1μg), a D2 receptor antagonist, and SMTC (40μg), an inhibitor of neuronal nitric oxide synthase, injected into the BNST 15min before oxytocin...
September 12, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28893930/how-human-amygdala-and-bed-nucleus-of-the-stria-terminalis-may-drive-distinct-defensive-responses
#3
Floris Klumpers, Marijn C W Kroes, Johanna Baas, Guillén Fernández
The ability to adaptively regulate responses to the proximity of potential danger is critical to survival and imbalance in this system may contribute to psychopathology. The bed nucleus of the stria terminalis (BNST) is implicated in defensive responding during uncertain threat anticipation whereas the amygdala may drive responding upon more acute danger. This functional dissociation between the BNST and amygdala is however controversial, and human evidence scarce. Here we utilized data from two independent functional magnetic resonance imaging studies (N=108 males & N=70 (45 females)) to probe how coordination between the BNST and amygdala may regulate responses during shock anticipation and actual shock confrontation...
September 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28855582/altered-cross-talk-between-the-hypothalamus-and-non-homeostatic-regions-linked-to-obesity-and-difficulty-to-lose-weight
#4
Oren Contreras-Rodríguez, Raquel Vilar-López, Zane B Andrews, Juan F Navas, Carles Soriano-Mas, Antonio Verdejo-García
Interactions between the hypothalamus and non-homeostatic regions may contribute to explain the difficulty to lose weight in obesity, an assumption never tested in human longitudinal studies. We investigated whether the functional connectivity between the medial and lateral hypothalamus (MH and LH) and corticostriatal regions differs between individuals with excess weight (n = 42) and normal weight (n = 39) using a seed-based resting-state approach. In addition, we examined the longitudinal association between functional connectivity and weight loss in a 3-month follow-up diet...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852859/neuronal-connections-of-the-central-amygdalar-nucleus-with-refeeding-activated-brain-areas-in-rats
#5
Györgyi Zséli, Barbara Vida, Anett Szilvásy-Szabó, Mónika Tóth, Ronald M Lechan, Csaba Fekete
Following fasting, satiety is accompanied by neuronal activation in brain areas including the central amygdalar nucleus (CEA). Since CEA is known to inhibit food intake, we hypothesized that CEA contributes to the termination of meal during refeeding. To better understand the organization of this satiety-related circuit, the interconnections of the CEA with refeeding-activated neuronal groups were elucidated using retrograde (cholera toxin-β subunit, CTB) and anterograde (phaseolus vulgaris leucoagglutinin, PHA-L) tracers in male rats...
August 29, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28826410/altered-functional-connectivity-of-the-subthalamus-and-the-bed-nucleus-of-the-stria-terminalis-in-obsessive-compulsive-disorder
#6
M Cano, P Alonso, I Martínez-Zalacaín, M Subirà, E Real, C Segalàs, J Pujol, N Cardoner, J M Menchón, C Soriano-Mas
BACKGROUND: The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of other clinically-effective DBS targets have not been explored. Here we evaluated the FC patterns of the subthalamic nucleus (STN) and the bed nucleus of the stria terminalis (BNST) in patients with OCD, as well as their association with symptom severity...
August 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28814474/role-of-the-bed-nucleus-of-the-stria-terminalis-in-aversive-learning-and-memory
#7
Travis D Goode, Stephen Maren
Surviving threats in the environment requires brain circuits for detecting (or anticipating) danger and for coordinating appropriate defensive responses (e.g., increased cardiac output, stress hormone release, and freezing behavior). The bed nucleus of the stria terminalis (BNST) is a critical interface between the "affective forebrain"-including the amygdala, ventral hippocampus, and medial prefrontal cortex-and the hypothalamic and brainstem areas that have been implicated in neuroendocrine, autonomic, and behavioral responses to actual or anticipated threats...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28764933/analysis-of-c-fos-induction-in-response-to-social-interaction-in-male-and-female-fisher-344-rats
#8
Amy E Perkins, Elizabeth R Woodruff, Lauren E Chun, Robert L Spencer, Elena Varlinskaya, Terrence Deak
Sex differences in the expression of social behavior are typically apparent in adolescent and adult rats. While the neurobiology underlying juvenile social play behavior has been well characterized, less is known about discrete brain regions involved in adult responsiveness to a same sex peer. Furthermore, whether adult males and females differ in their responsiveness to a social interaction in terms of neuronal activation indexed via immediate early gene (IEG) expression remains to be determined. Thus, the present study was designed to identify key sites relevant to the processing of sensory stimuli (generally) or social stimuli (specifically) after brief exposure to a same-sex social partner by assessing IEG expression...
October 1, 2017: Brain Research
https://www.readbyqxmd.com/read/28761080/serotonin-inputs-to-the-dorsal-bnst-modulate-anxiety-in-a-5-ht1a-receptor-dependent-manner
#9
A L Garcia-Garcia, S Canetta, J M Stujenske, N S Burghardt, M S Ansorge, A Dranovsky, E D Leonardo
Serotonin (5-HT) neurons project from the raphe nuclei throughout the brain where they act to maintain homeostasis. Here, we study 5-HT inputs into the bed nucleus of the stria terminalis (BNST), a major subdivision of the extended amygdala that has been proposed to regulate responses to anxiogenic environments in humans and rodents. While the dorsal part of the BNST (dBNST) receives dense 5-HT innervation, whether and how 5-HT in the dBNST normally modulates anxiety remains unclear. Using optogenetics, we demonstrate that activation of 5-HT terminals in the dBNST reduces anxiety in a highly anxiogenic environment...
August 1, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28714716/cb%C3%A2-receptor-antagonism-in-the-bed-nucleus-of-the-stria-terminalis-interferes-with-affective-opioid-withdrawal-in-rats
#10
Kiri L Wills, Marieka V DeVuono, Cheryl L Limebeer, Kiran Vemuri, Alexandros Makriyannis, Linda A Parker
The bed nucleus of the stria terminalis (BNST) is a region of the extended amygdala that is implicated in addiction, anxiety, and stress related behaviors. This region has been identified in mediating the aversive state of naloxone-precipitated morphine withdrawal (MWD) and cannabinoid Type I (CB1) receptors have been found to modulate neurotransmission within this region. Previous findings suggest that the CB1 antagonist/inverse agonist, AM251, administered systemically or by infusion into the central nucleus of the amygdala (CeA) prevented the aversive affective properties of MWD as measured by conditioned place aversion learning...
August 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28656976/pituitary-adenylate-cyclase-activating-peptide-in-the-bed-nucleus-of-the-stria-terminalis-mediates-stress-induced-reinstatement-of-cocaine-seeking-in-rats
#11
Olivia W Miles, Eric A Thrailkill, Anne K Linden, Victor May, Mark E Bouton, Sayamwong E Hammack
Stressors often contribute to difficulties in maintaining behavior change following a period of abstinence, and may play a significant role in drug relapse. The activation of pituitary adenylate cyclase activating peptide (PACAP) systems in the bed nucleus of the stria terminalis (BNST) mediates many consequences of chronic stressor exposure. Here we ask whether PACAP is also involved in producing reinstatement in a model of stress-induced relapse to drug taking. Rats self-administered cocaine for 1hr daily over 10 days, which was followed by 20 days of extinction training in which lever pressing no longer produced cocaine...
June 28, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28649992/a-key-role-for-neurotensin-in-chronic-stress-induced-anxiety-like-behavior-in-rats
#12
Catherine P Normandeau, Ana Paula Ventura-Silva, Emily R Hawken, Staci Angelis, Calvin Sjaarda, Xudong Liu, José Miguel Pêgo, É C Dumont
Chronic stress is a major cause of anxiety disorders that can be reliably modeled preclinically, providing insight into alternative therapeutic targets for this mental health illness. Neuropeptides have been targeted in the past to no avail possibly due to our lack of understanding of their role in pathological models. In this study we use a rat model of chronic stress-induced anxiety-like behaviors and hypothesized that neuropeptidergic modulation of synaptic transmission would be altered in the bed nucleus of the stria terminalis (BNST), a brain region suspected to contribute to anxiety disorders...
June 26, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28642284/excitation-of-gabaergic-neurons-in-the-bed-nucleus-of-the-stria-terminalis-triggers-immediate-transition-from-non-rapid-eye-movement-sleep-to-wakefulness-in-mice
#13
Shota Kodani, Shingo Soya, Takeshi Sakurai
Emotionally salient situations usually trigger arousal along with autonomic and neuroendocrine reactions. To determine whether the extended amygdala plays a role in sleep-wakefulness regulation, we examined the effects of optogenetic and pharmacogenetic excitation of GABAergic neurons in the bed nucleus of the stria terminalis (GABA(BNST) neurons). Acute optogenetic excitation of these cells during nonrapid eye movement (NREM) sleep resulted in an immediate state transition to wakefulness, whereas stimulation during REM sleep showed no effect on sleep-wakefulness states in male mice...
July 26, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28612996/crf1-and-crf2-receptors-in-the-bed-nucleus-of-stria-terminalis-differently-modulate-the-baroreflex-function-in-unanesthetized-rats
#14
Leandro A Oliveira, Jeferson Almeida, Lucas Gomes-de-Souza, Ricardo Benini, Carlos C Crestani
The baroreflex is an important blood pressure regulating mechanism. The bed nucleus of stria terminalis (BNST) modulates the baroreflex function. However, the local BNST neurochemical mechanisms involved in control of baroreflex responses are not completely understood. Therefore, in this study, we investigated the involvement of corticotropin-releasing factor (CRF) receptors within the BNST in baroreflex control of heart rate in unanesthetized rats. For this, we evaluated effects of bilateral microinjection into the BNST of either the selective CRF1 receptor antagonist CP376395 (5 nmol/100 nL) or the selective CRF2 receptor antagonist antisauvagine-30 (5 nmol/100 nL) in bradycardiac response evoked by blood pressure increases caused by intravenous infusion of phenylephrine as well as tachycardiac response to blood pressure decrease caused by intravenous infusion of sodium nitroprusside...
June 14, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28589966/role-of-%C3%AE%C2%BA-opioid-receptors-in-the-bed-nucleus-of-stria-terminalis-in-reinstatement-of-alcohol-seeking
#15
A D Lê, Douglas Funk, Kathleen Coen, Sahar Tamadon, Yavin Shaham
κ-Opioid receptors (KORs) and their endogenous ligand dynorphin are involved in stress-induced alcohol seeking but the mechanisms involved are largely unknown. We previously showed that systemic injections of the KOR agonist U50,488, which induce stress-like aversive states, reinstate alcohol seeking after extinction of the alcohol-reinforced responding. Here, we used the neuronal activity marker Fos and site-specific injections of the KOR antagonist nor-BNI and U50,488 to study brain mechanisms of U50,488-induced reinstatement of alcohol seeking...
June 7, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28539954/differential-histone-acetylation-in-sub-regions-of-bed-nucleus-of-the-stria-terminalis-underlies-fear-consolidation-and-extinction
#16
Vandana Ranjan, Sanjay Singh, Sarfraj Ahmad Siddiqui, Sukanya Tripathi, Mohd Yahiya Khan, Anand Prakash
OBJECTIVE: The hallmark of anxiety disorders is excessive fear. Previous studies have suggested that selective neural projections from Basal nucleus of stria terminalis (BNST) to amygdala and vice-versa precisely control the fear learning process. However the exact mechanism how the BNST controls fear consolidation and its extinction is largely unknown. In the present study we observed the changes in the BNST sub-regions following fear conditioning and its extinction. METHODS: The change in the number of positive neurons was determined by immunohistochemistry for Acetyl H3 (Histone 3), Acetyl H4 (Histone 4), cAMP response element binding Protein (CBP) and c-fos in three sub-regions of the BNST namely the anterio-lateral BNST (STLP) and anterio-medial BNST (STMA), and lateral-ventral BNST (STLV) of rats subjected to auditory fear conditioning and extinction...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28522214/p2-purinergic-receptor-antagonists-disrupt-maternal-behavior-in-lactating-rats
#17
Luciana C Teodoro, Layla D M Cabral, Fabiana C Vilela, Alexandre Giusti-Paiva
The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems. Therefore, the aim of our study was to investigate whether central administration of P2 receptor antagonists affected the maternal behavior of lactating rats and c-Fos immunoreactivity in the forebrain. On day 7 of lactation, female rats were treated with vehicle (5μL; i...
July 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28502843/disentangling-the-effects-of-novelty-valence-and-trait-anxiety-in-the-bed-nucleus-of-the-stria-terminalis-amygdala-and-hippocampus-with-high-resolution-7t-fmri
#18
Walker S Pedersen, L Tugan Muftuler, Christine L Larson
The hippocampus and amygdala exhibit sensitivity to stimulus novelty that is reduced in participants with inhibited temperament, which is related to trait anxiety. Although the bed nucleus of the stria terminalis (BNST) is highly connected to the amygdala and is implicated in anxiety, whether the BNST responds to novelty remains unstudied, as well as how trait anxiety may modulate this response. Additionally how novelty, stimulus negativity and trait anxiety interact to affect activity in these areas is also unclear...
August 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28485259/distinct-phasic-and-sustained-brain-responses-and-connectivity-of-amygdala-and-bed-nucleus-of-the-stria-terminalis-during-threat-anticipation-in-panic-disorder
#19
L Brinkmann, C Buff, K Feldker, S V Tupak, M P I Becker, M J Herrmann, T Straube
BACKGROUND: Panic disorder (PD) patients are constantly concerned about future panic attacks and exhibit general hypersensitivity to unpredictable threat. We aimed to reveal phasic and sustained brain responses and functional connectivity of the amygdala and the bed nucleus of the stria terminalis (BNST) during threat anticipation in PD. METHODS: Using functional magnetic resonance imaging (fMRI), we investigated 17 PD patients and 19 healthy controls (HC) during anticipation of temporally unpredictable aversive and neutral sounds...
May 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28419831/molecular-phenotyping-of-transient-postnatal-tyrosine-hydroxylase-neurons-in-the-rat-bed-nucleus-of-the-stria-terminalis
#20
David A Carter
The bed nucleus of the stria terminalis (BNST) is a complex integrative centre in the forebrain, composed of multiple sub-nuclei, each with discrete populations of neurons. Progress in understanding BNST function, both in the adult and during postnatal maturation, is dependent upon a more complete characterization of neuronal phenotypes in the BNST. The aim of the current study was to define the molecular phenotype of one postnatal BNST neuronal population, in order to identify molecular factors that may underlie both (protein marker-related) immaturity, and secondly, the transience of this phenotype...
April 15, 2017: Journal of Chemical Neuroanatomy
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