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Atezolizumab

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https://www.readbyqxmd.com/read/28043166/pharmacokinetic-drug-evaluation-of-atezolizumab-for-the-treatment-of-locally-advanced-or-metastatic-urothelial-carcinoma
#1
Rutveej Patel, Megan Bock, Charles F Polotti, Sammy Elsamra
Muscle invasive bladder cancer (MIBC) is difficult to manage for patients who progress during or after initial chemotherapy regimens. Current regimens offer low response rates with high toxicities. The advent of immune checkpoint inhibitors may represent a new opportunity for effective management of these patients. Areas covered: Atezolizumab is an engineered humanized monoclonal immunoglobulin G1 antibody that binds selectively to PD-L1 and prevents its interaction with PD-1 and B7-1. It is administered intravenously and is given every 3 weeks as long as there is no evidence of tumor progression...
January 3, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28031561/bladder-cancer-atezolizumab-an-alternative-to-cisplatin
#2
Peter Sidaway
No abstract text is available yet for this article.
December 29, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28031559/urological-cancer-atezolizumab-an-alternative-to-cisplatin
#3
Peter Sidaway
No abstract text is available yet for this article.
December 29, 2016: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/27997006/-nivolumab-in-second-line-treatment-of-squamous-non-small-cell-lung-cancer
#4
Filippo De Marinis, Antonio Passaro
The treatment of non-small cell lung cancer (NSCLC) is changing dramatically in the last period, considering both non-squamous and squamous disease. In the last five years, the identification of different molecular predictive biomarker (e.g., EGFR, ALK e ROS1) and the utilize of new chemotherapy agents associated or not with antiangiogenics agents (e.g., bevacizumab and nintedanib), allowed the improvement of survival and related responses to these treatments. However, these advances, did not allow an improvement of the same endpoints in the management of NSCLC with squamous cell histology (SCC), where until very recently, docetaxel in monotherapy remained as a corner stone treatment for the second line, although associated with an unfavorable toxicity profile...
December 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27981577/the-clinical-pharmacokinetics-and-pharmacodynamics-of-atezolizumab-in-metastatic-urothelial-carcinoma
#5
Mark Stroh, Helen Winter, Mathilde Marchand, Laurent Claret, Steve Eppler, Jane Ruppel, Oyewale Abidoye, Siew Leng Teng, Wan-Ting Lin, Sheila Dayog, Rene Bruno, Jin Jin, Sandhya Girish
Atezolizumab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting human programmed death-ligand 1, is FDA-approved in metastatic urothelial carcinoma (mUC) and is being investigated in various malignancies. This analysis, based upon 906 patients from two Phase I and one Phase II mUC studies, is the first report of the clinical pharmacokinetics and pharmacodynamics of atezolizumab. Atezolizumab exhibited linear pharmacokinetics over a dose range of 1 - 20 mg/kg, including the labeled 1200 mg dose...
December 16, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27979383/atezolizumab-versus-docetaxel-in-patients-with-previously-treated-non-small-cell-lung-cancer-oak-a-phase-3-open-label-multicentre-randomised-controlled-trial
#6
Achim Rittmeyer, Fabrice Barlesi, Daniel Waterkamp, Keunchil Park, Fortunato Ciardiello, Joachim von Pawel, Shirish M Gadgeel, Toyoaki Hida, Dariusz M Kowalski, Manuel Cobo Dols, Diego L Cortinovis, Joseph Leach, Jonathan Polikoff, Carlos Barrios, Fairooz Kabbinavar, Osvaldo Arén Frontera, Filippo De Marinis, Hande Turna, Jong-Seok Lee, Marcus Ballinger, Marcin Kowanetz, Pei He, Daniel S Chen, Alan Sandler, David R Gandara
BACKGROUND: Atezolizumab is a humanised antiprogrammed death-ligand 1 (PD-L1) monoclonal antibody that inhibits PD-L1 and programmed death-1 (PD-1) and PD-L1 and B7-1 interactions, reinvigorating anticancer immunity. We assessed its efficacy and safety versus docetaxel in previously treated patients with non-small-cell lung cancer. METHODS: We did a randomised, open-label, phase 3 trial (OAK) in 194 academic or community oncology centres in 31 countries. We enrolled patients who had squamous or non-squamous non-small-cell lung cancer, were 18 years or older, had measurable disease per Response Evaluation Criteria in Solid Tumors, and had an Eastern Cooperative Oncology Group performance status of 0 or 1...
December 12, 2016: Lancet
https://www.readbyqxmd.com/read/27969529/ps01-62-long-term-safety-and-clinical-activity%C3%A2-of-atezolizumab-monotherapy%C3%A2-in-metastatic-nsclc-final%C3%A2-results-from-a-phase-ia-study-topic-medical-oncology
#7
Michael S Gordon, Roy S Herbst, Leora Horn, Jean-Charles Soria, Leena Gandhi, Enriqueta Felip, Lecia Sequist, David R Spigel, Scott J Antonia, Ani Balmanoukian, Philippe Cassier, Bo Liu, Marcin Kowanetz, Carol O'Hear, Marcella Fassò, Alan Sandler, Scott N Gettinger
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969524/ps01-57-impower133-a-phase-i-iii-study-of-1l-atezolizumab-with-carboplatin-and-etoposide-in-patients-with-extensive-stage-sclc-topic-medical-oncology
#8
Leora Horn, Martin Reck, Tony Mok, Melissa L Johnson, Xiongwen Tang, Sivuonthanh Lam, Daniel Waterkamp, Ariel Lopez-Chavez, Alan Sandler, Giuseppe Giacconne, Stephen V Liu
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969523/ps01-56-impower110-phase-iii-trial-comparing-1l-atezolizumab-with-chemotherapy-in%C3%A2-pd-l1-selected-chemotherapy-naive-nsclc-patients-topic-medical-oncology
#9
Roy S Herbst, Filippo De Marinis, Jacek Jassem, Sivuonthanh Lam, Simonetta Mocci, Alan Sandler, Ariel Lopez-Chavez, Yu Deng, Giuseppe Giaccone, David R Spigel
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969522/ps01-55-impower010-phase-iii-study-of-atezolizumab-vs-bsc-after-adjuvant-chemotherapy-in-patients-with-completely-resected-nsclc-topic-medical-oncology
#10
Eric Vallieres, Enriqueta Felip, Nasser Altorki, Caicun Zhou, Yunxia Zuo, Michael Howland, Fan Xia, Tien Hoang, Alan Sandler, Heather Wakelee
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969521/ps01-54-evaluation-of-novel-blood-based-biomarkers-with-atezolizumab-monotherapy-in-1l-advanced-or-metastatic-nsclc-b-f1rst-topic-medical-oncology
#11
Mark A Socinski, Joan Schiller, Shaker Dakhil, Shayma Kazmi, Joseph Leach, Sylvia Hu, Sarah M Paul, David S Shames, See Phan, Cindy Yun, Vamsidhar Velcheti
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969520/ps01-53-first-line-atezolizumab-plus-chemotherapy-in-chemotherapy-naive-patients-with-advanced-nsclc-a-phase-iii-clinical-program-topic-medical-oncology
#12
Robert M Jotte, Mark A Socinski, Martin Reck, Vassiliki Papadimitrakopoulou, Howard J West, Tony Mok, Alan Sandler, Simonetta Mocci, Shelley Coleman, Takashi Asakawa, Federico Cappuzzo
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27969443/oral01-04-phase-ii-trial-of-atezolizumab-for-patients-with-pd-l1-selected-advanced-nsclc-birch-updated-efficacy-and-exploratory-biomarker-results-topic-medical-oncology
#13
Heather Wakelee, Jyoti D Patel, Rebecca Heist, Ani Balmanoukian, Benjamin Besse, Enriqueta Felip, Enric Carcereny Costa, Laura Q Chow, Marianna Koczywas, Marina C Garassino, Daniel Christoph, Chee Keong Toh, Melissa L Johnson, Jamie Chaft, Takayasu Kurata, Jiaheng Qiu, Marcin Kowanetz, Shelley Coleman, Simonetta Mocci, Alan Sandler, Scott N Gettinger, Solange Peters
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27960628/antibodies-to-watch-in-2017
#14
Janice M Reichert
Over 50 investigational monoclonal antibody (mAb) therapeutics are currently undergoing evaluation in late-stage clinical studies, which is expected to drive a trend toward first marketing approvals of at least 6-9 mAbs per year in the near-term. In the United States (US), a total of 6 and 9 mAbs were granted first approvals during 2014 and 2015, respectively; all these products are also approved in the European Union (EU). As of December 1, 2016, 6 mAbs (atezolizumab, olaratumab, reslizumab, ixekizumab, bezlotoxumab, oblitoxaximab) had been granted first approvals during 2016 in either the EU or US...
December 14, 2016: MAbs
https://www.readbyqxmd.com/read/27939400/atezolizumab-as-first-line-treatment-in-cisplatin-ineligible-patients-with-locally-advanced-and-metastatic-urothelial-carcinoma-a-single-arm-multicentre-phase-2-trial
#15
Arjun V Balar, Matthew D Galsky, Jonathan E Rosenberg, Thomas Powles, Daniel P Petrylak, Joaquim Bellmunt, Yohann Loriot, Andrea Necchi, Jean Hoffman-Censits, Jose Luis Perez-Gracia, Nancy A Dawson, Michiel S van der Heijden, Robert Dreicer, Sandy Srinivas, Margitta M Retz, Richard W Joseph, Alexandra Drakaki, Ulka N Vaishampayan, Srikala S Sridhar, David I Quinn, Ignacio Durán, David R Shaffer, Bernhard J Eigl, Petros D Grivas, Evan Y Yu, Shi Li, Edward E Kadel, Zachary Boyd, Richard Bourgon, Priti S Hegde, Sanjeev Mariathasan, AnnChristine Thåström, Oyewale O Abidoye, Gregg D Fine, Dean F Bajorin
BACKGROUND: First-line chemotherapy for patients with cisplatin-ineligible locally advanced or metastatic urothelial carcinoma is associated with short response duration, poor survival, and high toxicity. This study assessed atezolizumab (anti-programmed death-ligand 1 [PD-L1]) as treatment for metastatic urothelial cancer in cisplatin-ineligible patients. METHODS: For this single-arm, multicentre, phase 2 study, in 47 academic medical centres and community oncology practices in seven countries in North America and Europe, we recruited previously untreated patients with locally advanced or metastatic urothelial cancer who were cisplatin ineligible...
December 7, 2016: Lancet
https://www.readbyqxmd.com/read/27928185/drug-monographs-atezolizumab-and-everolimus
#16
Matthew A Green, J Aubrey Waddell, Dominic A Solimando
The complexity of cancer chemotherapy requires pharmacists be familiar with the complicated regimens and highly toxic agents used. This column reviews various issues related to preparation, dispensing, and administration of antineoplastic therapy, and the agents, both commercially available and investigational, used to treat malignant diseases. Questions or suggestions for topics should be addressed to Dominic A. Solimando, Jr., President, Oncology Pharmacy Services, Inc., 4201 Wilson Blvd #110-545, Arlington, VA 22203, email: OncRxSvc@comcast...
November 2016: Hospital Pharmacy
https://www.readbyqxmd.com/read/27920704/autoimmune-hemolytic-anemia-as-a-complication-of-nivolumab-therapy
#17
Amruth R Palla, Devin Kennedy, Hossain Mosharraf, Donald Doll
Recently, immunotherapeutic drugs, including PD-1 inhibitors (nivolumab, pembrolizumab), PD-L1 inhibitors (atezolizumab, avelumab), and CTLA4 inhibitors (ipiliumumab), have emerged as important additions to the armamentarium against certain malignancies and have been incorporated into therapeutic protocols for first-, second-, or third-line agents for these metastatic cancers. Immune checkpoint inhibitor nivolumab is currently FDA approved for the treatment of patients with metastatic malignant melanoma [Redman et al...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27920140/first-anti-pd-l1-drug-approved-for-nsclc
#18
(no author information available yet)
Based on the results of two large international randomized trials, the FDA approved the anti-PD-L1 agent atezolizumab in October. It is the first PD-L1 inhibitor approved for use in patients with metastatic non-small cell lung cancer that has advanced in spite of treatment with platinum-based chemotherapy.
December 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27903674/atezolizumab-a-pd-l1-blocking-antibody-for-bladder-cancer
#19
Brant A Inman, Thomas A Longo, Sundhar Ramalingam, Michael R Harrison
Atezolizumab (Tecentriq™, MPDL3280A) is an FcγR-binding deficient, fully humanized, IgG1 monoclonal antibody designed to interfere with the binding of PD-L1 ligand to its two receptors, PD-1 and B7.1. By blocking the PD-L1/PD-1 immune checkpoint, atezolizumab reduces immunosuppressive signals found within the tumor microenvironement and consequently increases T cell mediated immunity against the tumor. Atezolizumab has been FDA-approved as second-line therapy for advanced bladder cancer. This accelerated approval was based on phase 2 trial data in patients with metastatic bladder cancer that showed unexpected and durable tumor responses...
November 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27894673/treatment-related-death-in-cancer-patients-treated-with-immune-checkpoint-inhibitors-a-systematic-review-and-meta-analysis
#20
O Abdel-Rahman, D Helbling, J Schmidt, U Petrausch, A Giryes, A Mehrabi, O Schöb, M Mannhart, H Oweira
AIMS: We carried out a meta-analysis to determine the risk of treatment-related death associated with immune checkpoint inhibitor use in cancer patients. MATERIALS AND METHODS: We examined data from the Medline and Google Scholar databases. We also examined original studies and review articles for cross-references. Eligible studies included randomised phase II and phase III trials of patients with cancer treated with ipilimumab, pembrolizumab; nivolumab; tremelimumab and atezolizumab...
November 25, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
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