keyword
MENU ▼
Read by QxMD icon Read
search

heroin addict

keyword
https://www.readbyqxmd.com/read/28100012/characterization-and-management-of-patients-with-heroin-versus-non-heroin-opioid-overdoses-experience-at-an-academic-medical-center
#1
Kate M Morizio, Regan A Baum, Adam Dugan, Julia E Marin, Abby M Bailey
STUDY OBJECTIVES: To characterize the differences between patients who had heroin and non-heroin opioid overdoses and to determine whether there were any significant differences in their management with regard to the naloxone use. DESIGN: Retrospective cohort study. SETTING: Large, academic medical center. PATIENTS: A total of 923 patients admitted to the medical center who were identified for overdose by heroin or other opiate-related narcotics between January 2010 and September 2015; 480 patients experienced a non-heroin opioid overdose event, and 443 patients experienced a heroin overdose event...
January 18, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28093220/increased-oxytocin-levels-among-abstinent-heroin-addicts-association-with-aggressiveness-psychiatric-symptoms-and-perceived-childhood-neglect
#2
Lidia M Gerra, Gilberto Gerra, Laura Mercolini, Matteo Manfredini, Lorenzo Somaini, Chiara M Pieri, Maina Antonioni, Michele Protti, Paolo Ossola, Carlo Marchesi
A disruption of the oxytocin system seems to affect a variety of brain functions including emotions, mood and social behavior possibly underlying severe social deficits and susceptibility for substance use and mental health disorders. Early life adversity, such as insecure attachment in childhood, has been suggested to influence oxytocin tone contributing to a condition of neurobiological vulnerability. Aim of the present study was to investigate oxytocin serum levels in abstinent heroin addicted patients, in comparison with healthy controls, and the possible correlation with co-occurring psychiatric symptoms, aggressiveness and perception of parental neglect...
January 13, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28074855/mir-218-targets-mecp2-and-inhibits-heroin-seeking-behavior
#3
Biao Yan, Zhaoyang Hu, Wenqing Yao, Qiumin Le, Bo Xu, Xing Liu, Lan Ma
MicroRNAs (miRNAs) are a class of evolutionarily conserved, 18-25 nucleotide non-coding sequences that post-transcriptionally regulate gene expression. Recent studies implicated their roles in the regulation of neuronal functions, such as learning, cognition and memory formation. Here we report that miR-218 inhibits heroin-induced behavioral plasticity. First, network propagation-based method was used to predict candidate miRNAs that played potential key roles in regulating drug addiction-related genes. Microarray screening was also carried out to identify miRNAs responding to chronic heroin administration in the nucleus accumbens (NAc)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065255/a-54-year-old-man-with-lingual-granuloma-and-multiple-pulmonary-excavated-nodules
#4
Julien Dang, Noémie Chanson, Caroline Charlier, Christine Bonnal, Gregory Jouvion, Tiphaine Goulenok, Thomas Papo, Karim Sacre
A 54-year-old French man was admitted for evaluation of a chronic nodular lesion of the tongue and mandibular lymphadenopathy. He reported active tobacco and cannabis smoking as well as excessive alcohol use. He also reported frequent use of cocaine for several months and a past addiction to IV heroin. He had traveled abroad as a journalist and lived for several months in Columbia and Venezuela 12 years ago. His medical history included chronic hepatitis C infection successfully treated with interferon and ribavirin 6 years ago and high BP...
January 2017: Chest
https://www.readbyqxmd.com/read/28035035/analysis-of-u-47700-a-novel-synthetic-opioid-in-human-urine-by-lc-ms-ms-and-lc-qtof
#5
Steven W Fleming, Justin C Cooley, Leonard Johnson, C Clinton Frazee, Kristina Domanski, Kurt Kleinschmidt, Uttam Garg
The illicit drug market has rapidly evolved from synthetic cannabinoids to cathinone derivatives and now a new emerging threat of synthetic opioids. These compounds were mostly developed by pharmaceutical companies during drug discovery. The new psychoactive substances are not routinely covered in drug screening and may go undetected. Recently fentanyl analogous, AH-7921, MT-45 and now U-47700 have been encountered in clinical and forensic casework. U-47700 is gaining popularity on drug user forms as a legal alternative to heroin...
December 29, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28013479/idling-in-mao-s-shadow-heroin-addiction-and-the-contested-therapeutic-value-of-socialist-traditions-of-laboring
#6
Nicholas Bartlett
The Chinese government has come under attack by international critics for forcing drug users to labor in the name of treatment. While joining these activists in criticizing conditions in compulsory labor centers, former detainees who congregated at a drop-in center in southern Yunnan also defended the therapeutic potential of socialist legacies of laboring. Shuttling between laboring in state compulsory centers and idling in a market economy, long-term heroin users saw their difficulties in recovering from addiction as inextricably linked to their inability to find suitable work opportunities...
December 24, 2016: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28001458/similarity-and-difference-in-drug-addiction-process-between-heroin-and-methamphetamine-dependent-users
#7
Ziyun Wang, Wei-Xiu Li, Liu Zhi-Min
OBJECTIVES: This study aimed to compare the drug addiction process between Chinese heroin- and methamphetamine (MA)-dependent users via a modified 4-stage addiction model (experimentation, occasional use, regular use, and compulsive use). METHODS: A descriptive study was conducted among 683 eligible participants. In the statistical analysis, we selected 340 heroin- and 295 MA-dependent users without illicit drug use prior to onset of heroin or MA use. RESULTS: The addiction process of heroin-dependent users was shorter than that of MA-dependent users, with shorter transitions from the onset of drug-use to the first drug craving (19...
December 21, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27997065/depression-and-severity-of-substance-dependence-among-heroin-dependent-patients-with-adhd-symptoms
#8
Yin-To Liao, Chi-Yen Chen, Mei-Hing Ng, Kuo-You Huang, Wen-Chuan Shao, Tsang-Yaw Lin, Vincent Chin-Hung Chen, Michael Gossop
BACKGROUND AND OBJECTIVES: Comorbid attention deficit hyperactivity disorder (ADHD) symptoms are highly prevalent among heroin-dependent patients. We aim to investigate differences in dependence severity, depression, and quality of life between heroin-dependent patients with and without ADHD-screened positive. METHODS: Heroin-dependent participants (n = 447) entering methadone maintenance treatment were divided into ADHD-screened positive (ADHD-P) and ADHD-screened negative (ADHD-N) groups according to scores of Adult ADHD Self-Report Scale (ASRS)...
January 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/27936112/genome-wide-association-of-heroin-dependence-in-han-chinese
#9
Gursharan Kalsi, Jack Euesden, Jonathan R I Coleman, Francesca Ducci, Fazil Aliev, Stephen J Newhouse, Xiehe Liu, Xiaohong Ma, Yingcheng Wang, David A Collier, Philip Asherson, Tao Li, Gerome Breen
Drug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers. To date, genome-wide association studies (GWAS) for heroin addiction have been limited; moreover they have been restricted to examining samples of European and African-American origin due to difficulty of recruiting samples from other populations. This is the first study to test a Han Chinese population; we performed a GWAS on a homogeneous sample of 370 Han Chinese subjects diagnosed with heroin dependence using the DSM-IV criteria and 134 ethnically matched controls...
2016: PloS One
https://www.readbyqxmd.com/read/27933094/the-newer-opioid-agonist-treatment-with-lower-substitutive-opiate-doses-is-associated-with-better-toxicology-outcome-than-the-older-harm-reduction-treatment
#10
Jacopo V Bizzarri, Valentina Casetti, Livia Sanna, Angelo Giovanni Icro Maremmani, Luca Rovai, Silvia Bacciardi, Daria Piacentino, Andreas Conca, Icro Maremmani
BACKGROUND: Charge-free heroin use disorder treatment in Italy follows two main approaches, i.e., harm reduction treatment (HRT) strategy in community low-threshold facilities for drug addiction and opioid agonist treatment (OAT) in high-threshold facilities for opioid addiction, focusing on pharmacological maintenance according to the Dole and Nyswander strategy. We aimed to compare the impact of HRT and OAT on patient outcome, as assessed through negativity for drugs on about 1-year urinalyses...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27917870/high-frequency-stimulation-of-the-subthalamic-nucleus-blocks-compulsive-like-re-escalation-of-heroin-taking-in-rats
#11
Carrie L Wade, Marsida Kallupi, Daniel O Hernandez, Emmanuel Breysse, Giordano de Guglielmo, Elena Crawford, George F Koob, Paul Schweitzer, Christelle Baunez, Olivier George
Opioid addiction, including addiction to heroin, has dramatically increased in the last decade. The cost and pervasiveness of heroin addiction, including resistance to recovery from addiction, provide a compelling basis for developing novel therapeutic strategies. Deep brain stimulation may represent a viable alternative strategy for the treatment of intractable heroin addiction particularly in individuals who are resistant to traditional therapies. Here, we provide preclinical evidence of the therapeutic potential of high-frequency stimulation of the subthalamic nucleus (STN HFS) for heroin addiction...
December 5, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27898133/opioid-misuse-abuse-and-quality-persistent-pain-management-in-older-adults
#12
Yu-Ping Chang, Peggy Compton
The United States is amid an epidemic of prescription opioid drug abuse, bringing with it not only high rates of overdose, but growing rates of heroin abuse and addiction. Liberal opioid drug prescribing on the part of well-meaning clinicians has in part fueled this epidemic, being correlated to opioid death and addiction treatment admission rates. Misuse and abuse of prescription opioid drugs is greatest among young adults (ages 18 to 25); however, the fastest growing age group for opioid drug misuse/abuse is older (ages 50 to 64)...
December 1, 2016: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27893214/public-perceptions-of-behavioral-and-substance-addictions
#13
Brent Lang, Harold Rosenberg
Most of the research on public perceptions of people with addictive disorders has focused on alcohol and illicit drugs, rather than addiction to behavioral activities. To expand the range of addictive behaviors and types of perceptions studied, we designed the present study to assess the lay public's definitions of and willingness to affiliate with people described as addicted to 1 of 2 specific behaviors (i.e., pornography or gambling) or 1 of 3 specific substances (i.e., alcohol, marijuana, or heroin). A nationwide convenience sample (N = 612) of American adults completed online questionnaires during the summer of 2015...
November 28, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27890603/a-novel-inhibitor-of-endocannabinoid-catabolic-enzymes-sheds-light-on-behind-the-scene-interplay-between-chronic-pain-analgesic-tolerance-and-heroin-dependence
#14
Josée Guindon
From the Aristotelian ancient Greece, pain has been associated with appetites or emotions and is opposite to pleasure. Reward and addiction is also linked to pleasure and compulsive drug seeking reinstates pleasure. Alleviation of chronic pain can induce a euphoric phase similar to what is found in addiction. Both chronic pain and addiction are recognized as a disease of the central nervous system. They share many characteristics and brain regions/mechanisms. Evidence points to the usefulness of cannabinoids as a new class of agents to add to the pharmaceutical toolbox in the management of chronic pain...
March 1, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27884551/resting-state-abnormalities-in-heroin-dependent-individuals
#15
REVIEW
Niki Pandria, Leda Kovatsi, Ana B Vivas, Panagiotis D Bamidis
Drug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific prefrontal, parietal, occipital, and temporal regions, as well as, some subcortical regions. The brain regions involved are usually linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control and seem to form circuits that interact with each other...
November 21, 2016: Neuroscience
https://www.readbyqxmd.com/read/27882209/marketed-new-drug-delivery-systems-for-opioid-agonists-antagonists-administration-a-rapid-overview
#16
REVIEW
Hoda Soltani, Abbas Pardakhty
Novel drug delivery systems for controlled-release of opioid agonists as a long time painkillers or opioid antagonists for opium, heroin, and alcohol addiction are under development or in clinical use today. In this article, the field of "new drug delivery systems" is momentarily reviewed from the viewpoint of the marketed opioid agonists/antagonists dosage forms today.
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27863698/striatal-h3k27-acetylation-linked-to-glutamatergic-gene-dysregulation-in-human-heroin-abusers-holds-promise-as-therapeutic-target
#17
Gabor Egervari, Joseph Landry, James Callens, John F Fullard, Panos Roussos, Eva Keller, Yasmin L Hurd
BACKGROUND: Opiate abuse and overdose reached epidemic levels in the United States. However, despite significant advances in animal and in vitro models, little knowledge has been directly accrued regarding the neurobiology of the opiate-addicted human brain. METHODS: We used postmortem human brain specimens from a homogeneous European Caucasian population of heroin users for transcriptional and epigenetic profiling, as well as direct assessment of chromatin accessibility in the striatum, a brain region central to reward and emotion...
September 28, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27862172/investigation-of-brain-electrophysiological-properties-among-heroin-addicts-quantitative-eeg-and-event-related-potentials
#18
Farid Motlagh, Fatimah Ibrahim, Rusdi Rashid, Tahereh Seghatoleslam, Hussain Habil
This study aims to introduce a new approach of a comprehensive paradigm to evaluate brain electrophysiological properties among addicts. Electroencephalographic spectral power as well as amplitudes and latencies of mismatch negativity (MMN), P300, and P600 components were evaluated among 19 male heroin addicts and 19 healthy nonsmoker subjects using a paradigm consisting of three subparadigms, namely (1) digit span Wechsler test, (2) auditory oddball, and (3) visual cue-reactivity oddball paradigms. Task 1 provided auditory P300 and P600 in association with working memory...
November 8, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27833645/the-impact-of-psychopathological-subtypes-on-retention-rate-of-patients-with-substance-use-disorder-entering-residential-therapeutic-community-treatment
#19
Angelo G I Maremmani, Pier Paolo Pani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Marina Davoli, Fabrizio Faggiano, Icro Maremmani
BACKGROUND: A specific psychopathology of addiction has been proposed and described using the self-report symptom inventory (SCL-90), leading to a 5-factor aggregation of psychological/psychiatric symptoms: 'worthlessness and being trapped', 'somatic symptoms', 'sensitivity-psychoticism', 'panic-anxiety' and 'violence-suicide' in various populations of patients with heroin use disorder (HUD) and other substance use disorders (SUDs). These clusters of symptoms, according to studies that have highlighted the role of possible confounding factors (such as demographic and clinical characteristics, active heroin use, lifetime psychiatric problems and kind of treatment received by the patients), seem to constitute a trait rather than a state of the psychological structure of addiction...
2016: Annals of General Psychiatry
https://www.readbyqxmd.com/read/27824052/augmentation-of-heroin-seeking-following-chronic-food-restriction-in-the-rat-differential-role-for-dopamine-transmission-in-the-nucleus-accumbens-shell-and-core
#20
Tracey M D'Cunha, Emilie Daoud, Damaris Rizzo, Audrey B Bishop, Melissa Russo, Gabrielle Mourra, Laurie Hamel, Firas Sedki, Uri Shalev
Caloric restriction during drug abstinence increases the risk for relapse in addicts. In rats, chronic food restriction during a period of withdrawal following heroin self-administration augments heroin seeking. The mechanisms underlying this effect are largely unknown. Here, we investigated the role of nucleus accumbens (NAc) shell and core dopamine (DA) in food restriction-induced augmentation of heroin seeking. Rats were trained to self-administer heroin (0.1 mg/kg/infusion) for 10 days. Next, rats were moved to the animal colony for a withdrawal period, during which rats were food restricted to 90% of their original body weight (FDR group) or given unrestricted access to food (sated group)...
December 7, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
keyword
keyword
77513
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"