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https://www.readbyqxmd.com/read/27925141/nutritional-interventions-that-slow-the-age-associated-decline-in-renal-function-in-a-canine-geriatric-model-for-elderly-humans
#1
J A Hall, M Yerramilli, E Obare, M Yerramilli, K S Panickar, G Bobe, D E Jewell
OBJECTIVE: To determine the effects of feeding traditional and renal protective foods (RPF) supplemented with functional food bioactives on glomerular filtration rate (GFR), lean body percent (LB%), and selected circulating biomarker and metabolite concentrations in a geriatric dog model. DESIGN: Randomized block design and cross-sectional study. SETTING: Hill's Pet Nutrition, Inc. dog colony. PARTICIPANTS: Eighty-one geriatric dogs (mean age, 10...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27924852/low-temperature-magneto-morphological-characterisation-of-coronene-and-the-resolution-of-previously-observed-unexplained-phenomena
#2
Jason Potticary, Rebecca Boston, Liana Vella-Zarb, Alex Few, Christopher Bell, Simon R Hall
The polyaromatic hydrocarbon coronene has been the molecule of choice for understanding the physical properties of graphene for over a decade. The modelling of the latter by the former was considered to be valid, as since it was first synthesised in 1932, the physical behaviour of coronene has been determined extremely accurately. We recently discovered however, an unforeseen polymorph of coronene, which exists as an enantiotrope with the previously observed crystal structure. Using low-temperature magnetisation and crystallographic measurements, we show here for the first time that the electronic and magnetic properties of coronene depend directly on the temperature at which it is observed, with hysteretic behaviour exhibited between 300 K and 100 K...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924337/allosteric-effects-of-gold-nanoparticles-on-human-serum-albumin
#3
Qing Shao, Carol K Hall
The ability of nanoparticles to alter protein structure and dynamics plays an important role in their medical and biological applications. We investigate allosteric effects of gold nanoparticles on human serum albumin protein using molecular simulations. The extent to which bound nanoparticles influence the structure and dynamics of residues distant from the binding site is analyzed. The root mean square deviation, root mean square fluctuation and variation in the secondary structure of individual residues on a human serum albumin protein are calculated for four protein-gold nanoparticle binding complexes...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27922004/annually-resolved-north-atlantic-marine-climate-over-the-last-millennium
#4
D J Reynolds, J D Scourse, P R Halloran, A J Nederbragt, A D Wanamaker, P G Butler, C A Richardson, J Heinemeier, J Eiríksson, K L Knudsen, I R Hall
Owing to the lack of absolutely dated oceanographic information before the modern instrumental period, there is currently significant debate as to the role played by North Atlantic Ocean dynamics in previous climate transitions (for example, Medieval Climate Anomaly-Little Ice Age, MCA-LIA). Here we present analyses of a millennial-length, annually resolved and absolutely dated marine δ(18)O archive. We interpret our record of oxygen isotope ratios from the shells of the long-lived marine bivalve Arctica islandica (δ(18)O-shell), from the North Icelandic shelf, in relation to seawater density variability and demonstrate that solar and volcanic forcing coupled with ocean circulation dynamics are key drivers of climate variability over the last millennium...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27916258/the-apicoplast-genomes-of-two-taxonomic-units-of-babesia-from-sheep
#5
Tao Wang, Guiquan Guan, Pasi K Korhonen, Anson V Koehler, Ross S Hall, Neil D Young, Hong Yin, Robin B Gasser
The apicoplast (ap) is a unique, non-photosynthetic organelle found in most apicomplexan parasites. Due to the essential roles that this organelle has, it has been widely considered as target for drugs against diseases caused by apicomplexans. Exploring the ap genomes of such parasites would provide a better understanding of their systematics and their basic molecular biology for therapeutics. However, there is limited information available on the ap genomes of apicomplexan parasites. In the present study, the ap genomes of two operational taxonomic units of Babesia (known as Babesia sp...
November 6, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27911532/spin-nernst-effect-of-magnons-in-collinear-antiferromagnets
#6
Ran Cheng, Satoshi Okamoto, Di Xiao
In a collinear antiferromagnet with easy-axis anisotropy, symmetry guarantees that the spin wave modes are doubly degenerate. The two modes carry opposite spin angular momentum and exhibit opposite chirality. Using a honeycomb antiferromagnet in the presence of the Dzyaloshinskii-Moriya interaction, we show that a longitudinal temperature gradient can drive the two modes to opposite transverse directions, realizing a spin Nernst effect of magnons with vanishing thermal Hall current. We find that magnons around the Γ point and the K point contribute oppositely to the transverse spin transport, and their competition leads to a sign change of the spin Nernst coefficient at finite temperature...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27910646/a-streaked-x-ray-spectroscopy-platform-for-rapidly-heated-near-solid-density-plasmas
#7
C R Stillman, P M Nilson, S T Ivancic, C Mileham, I A Begishev, R K Junquist, D J Nelson, D H Froula
A picosecond, time-resolved, x-ray spectroscopy platform was developed to study the thermal line emission from rapidly heated solid targets containing buried aluminum or iron layers. The targets were driven by high-contrast 1ω or 2ω laser pulses at focused intensities up to 1 × 10(19) W/cm(2). The experimental platform combines time-integrating and time-resolved x-ray spectrometers. Picosecond time resolution was achieved with a pair of ultrafast x-ray streak cameras coupled to high-throughput Hall spectrometers...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910624/a-scanning-hall-probe-microscope-for-high-resolution-large-area-variable-height-magnetic-field-imaging
#8
Gorky Shaw, R B G Kramer, N M Dempsey, K Hasselbach
We present a scanning Hall probe microscope operating in ambient conditions. One of the unique features of this microscope is the use of the same stepper motors for both sample positioning as well as scanning, which makes it possible to have a large scan range (few mm) in the x and y directions, with a scan resolution of 0.1 μm. Protocols have been implemented to enable scanning at different heights from the sample surface. The z range is 35 mm. Microstructured Hall probes of size 1-5 μm have been developed...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910418/observation-of-hohlraum-wall-motion-with-spectrally-selective-x-ray-imaging-at-the-national-ignition-facility
#9
N Izumi, N B Meezan, L Divol, G N Hall, M A Barrios, O Jones, O L Landen, J J Kroll, S A Vonhof, A Nikroo, J Jaquez, C G Bailey, C M Hardy, R B Ehrlich, R P J Town, D K Bradley, D E Hinkel, J D Moody
The high fuel capsule compression required for indirect drive inertial confinement fusion requires careful control of the X-ray drive symmetry throughout the laser pulse. When the outer cone beams strike the hohlraum wall, the plasma ablated off the hohlraum wall expands into the hohlraum and can alter both the outer and inner cone beam propagations and hence the X-ray drive symmetry especially at the final stage of the drive pulse. To quantitatively understand the wall motion, we developed a new experimental technique which visualizes the expansion and stagnation of the hohlraum wall plasma...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910309/spatial-resolution-measurements-of-the-advanced-radiographic-capability-x-ray-imaging-system-at-energies-relevant-to-compton-radiography
#10
G N Hall, N Izumi, O L Landen, R Tommasini, J P Holder, D Hargrove, D K Bradley, A Lumbard, J G Cruz, K Piston, J J Lee, E Romano, P M Bell, A C Carpenter, N E Palmer, B Felker, V Rekow, F V Allen
Compton radiography provides a means to measure the integrity, ρR and symmetry of the DT fuel in an inertial confinement fusion implosion near peak compression. Upcoming experiments at the National Ignition Facility will use the ARC (Advanced Radiography Capability) laser to drive backlighter sources for Compton radiography experiments and will use the newly commissioned AXIS (ARC X-ray Imaging System) instrument as the detector. AXIS uses a dual-MCP (micro-channel plate) to provide gating and high DQE at the 40-200 keV x-ray range required for Compton radiography, but introduces many effects that contribute to the spatial resolution...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908292/conservatively-treated-congenital-hyperinsulinism-chi-due-to-k-atp-channel-gene-mutations-reducing-severity-over-time
#11
Maria Salomon-Estebanez, Sarah E Flanagan, Sian Ellard, Lindsey Rigby, Louise Bowden, Zainab Mohamed, Jacqueline Nicholson, Mars Skae, Caroline Hall, Ross Craigie, Raja Padidela, Nuala Murphy, Tabitha Randell, Karen E Cosgrove, Mark J Dunne, Indraneel Banerjee
BACKGROUND: Patients with Congenital Hyperinsulinism (CHI) due to mutations in K-ATP channel genes (K-ATP CHI) are increasingly treated by conservative medical therapy without pancreatic surgery. However, the natural history of medically treated K-ATP CHI has not been described; it is unclear if the severity of recessively and dominantly inherited K-ATP CHI reduces over time. We aimed to review variation in severity and outcomes in patients with K-ATP CHI treated by medical therapy. METHODS: Twenty-one consecutively presenting patients with K-ATP CHI with dominantly and recessively inherited mutations in ABCC8/KCNJ11 were selected in a specialised CHI treatment centre to review treatment outcomes...
December 1, 2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/27906230/stability-of-a-frequency-comb-based-transfer-lock-using-a-passive-fabry-perot-resonator
#12
Sambit B Pal, Mark M Lam, K Dieckmann
We report on a transfer-lock laser frequency stabilization that utilizes a frequency comb (FC) and a radio frequency counter referenced to a GPS frequency standard to compensate for the frequency drifts of two lasers, which are locked to a single passive Fabry-Perot resonator (FPR). The method requires only one optical phase lock with the FC and allows transfer locking of lasers at wavelengths beyond the usable range of the FC. To attain a large frequency tuning range for the lasers, we implement optical serrodyning...
December 1, 2016: Optics Letters
https://www.readbyqxmd.com/read/27902826/association-of-a-frailty-screening-initiative-with-postoperative-survival-at-30-180-and-365-days
#13
Daniel E Hall, Shipra Arya, Kendra K Schmid, Mark A Carlson, Pierre Lavedan, Travis L Bailey, Georgia Purviance, Tammy Bockman, Thomas G Lynch, Jason M Johanning
Importance: As the US population ages, the number of operations performed on elderly patients will likely increase. Frailty predicts postoperative mortality and morbidity more than age alone, thus presenting opportunities to identify the highest-risk surgical patients and improve their outcomes. Objective: To examine the effect of the Frailty Screening Initiative (FSI) on mortality and complications by comparing the surgical outcomes of a cohort of surgical patients treated before and after implementation of the FSI...
November 30, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27900382/ultra-fast-preparation-of-high-performance-thermoelectric-bulk-tinisb0-05sn0-95-by-microwave-synthesis
#14
Y Li, C Cheng, Y Lei, M Wang, R D Wan
The antimony-doped half-Heusler thermoelectric bulk TiNiSb0.05Sn0.95 was prepared via ultra-fast 4.5 min microwave synthesis, cold-press forming and 20 min microwave pressureless sintering. The electrical properties i.e. the Seebeck coefficient (S), electrical resistivity (ρ), and carrier concentration (n) and mobility (μ) were measured on a Seebeck coefficient/resistance analysis system (S/RAs) and Hall effect measurement system (HEMS), respectively. The thermal conductivity (κ) was measured on a laser flash thermal analyzer (LFA)...
November 30, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27899326/complete-plastid-genome-sequence-of-goosegrass-eleusine-indica-and-comparison-with-other-poaceae
#15
Hui Zhang, Nathan Hall, J Scott McElroy, Elijah K Lowe, Leslie R Goertzen
Eleusine indica, also known as goosegrass, is a serious weed in at least 42 countries. In this paper we report the complete plastid genome sequence of goosegrass obtained by de novo assembly of paired-end and mate-paired reads generated by Illumina sequencing of total genomic DNA. The goosegrass plastome is a circular molecule of 135,151bp in length, consisting of two single-copy regions separated by a pair of inverted repeats (IRs) of 20,919 bases. The large (LSC) and the small (SSC) single-copy regions span 80,667 bases and 12,646 bases, respectively...
November 26, 2016: Gene
https://www.readbyqxmd.com/read/27893030/development-and-initial-validation-of-the-risk-analysis-index-for-measuring-frailty-in-surgical-populations
#16
Daniel E Hall, Shipra Arya, Kendra K Schmid, Casey Blaser, Mark A Carlson, Travis L Bailey, Georgia Purviance, Tammy Bockman, Thomas G Lynch, Jason Johanning
Importance: Growing consensus suggests that frailty-associated risks should inform shared surgical decision making. However, it is not clear how best to screen for frailty in preoperative surgical populations. Objective: To develop and validate the Risk Analysis Index (RAI), a 14-item instrument used to measure surgical frailty. It can be calculated prospectively (RAI-C), using a clinical questionnaire, or retrospectively (RAI-A), using variables from the surgical quality improvement databases (Veterans Affairs or American College of Surgeons National Surgical Quality Improvement Projects)...
November 23, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27891592/evaluation-of-a-cow-side-milk-progesterone-assay-and-assessment-of-the-positive-predictive-value-of-oestrus-diagnosis-by-dairy-farmers-in-new-south-wales
#17
L Ingenhoff, E Hall, J K House
OBJECTIVES: The three objectives of this study were to determine the positive predictive value (PPV) of oestrus diagnosis (heat detection accuracy) by dairy farmers, calculate the diagnostic sensitivity and specificity of the P4 Rapid milk progesterone assay for detecting a corpus luteum and evaluate the economics of using a cow-side milk progesterone assay designed to aid oestrus diagnosis. METHODS: Milk samples were collected from 752 cows diagnosed in oestrus by farm personnel on 14 dairy farms...
December 2016: Australian Veterinary Journal
https://www.readbyqxmd.com/read/27885618/pre-clinical-quantitative-imaging-and-mouse-specific-dosimetry-for-111-in-labelled-radiotracers
#18
Ana M Denis-Bacelar, Sarah E Cronin, Chiara Da Pieve, Rowena L Paul, Sue A Eccles, Terence J Spinks, Carol Box, Adrian Hall, Jane K Sosabowski, Gabriela Kramer-Marek, Glenn D Flux
BACKGROUND: Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study was to investigate the challenges and feasibility of pre-clinical quantitative imaging and mouse-specific dosimetry of (111)In-labelled radiotracers. Attenuation, scatter and partial volume effects were studied using phantom experiments, and an activity calibration curve was obtained for varying sphere sizes...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27878470/%C3%AE-2-agonists
#19
Charlotte K Billington, Raymond B Penn, Ian P Hall
History suggests β agonists, the cognate ligand of the β2 adrenoceptor, have been used as bronchodilators for around 5,000 years, and β agonists remain today the frontline treatment for asthma and chronic obstructive pulmonary disease (COPD). The β agonists used clinically today are the products of significant expenditure and over 100 year's intensive research aimed at minimizing side effects and enhancing therapeutic usefulness. The respiratory physician now has a therapeutic toolbox of long acting β agonists to prophylactically manage bronchoconstriction, and short acting β agonists to relieve acute exacerbations...
November 23, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27876059/a-prospective-observational-cohort-study-in-primary-care-practices-to-identify-factors-associated-with-treatment-failure-in-staphylococcus-aureus-skin-and-soft-tissue-infections
#20
Grace C Lee, Ronald G Hall, Natalie K Boyd, Steven D Dallas, Liem C Du, Lucina B Treviño, Sylvia B Treviño, Chad Retzloff, Kenneth A Lawson, James Wilson, Randall J Olsen, Yufeng Wang, Christopher R Frei
BACKGROUND: The incidence of outpatient visits for skin and soft tissue infections (SSTIs) has substantially increased over the last decade. The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has made the management of S. aureus SSTIs complex and challenging. The objective of this study was to identify risk factors contributing to treatment failures associated with community-associated S. aureus skin and soft tissue infections SSTIs. METHODS: This was a prospective, observational study among 14 primary care clinics within the South Texas Ambulatory Research Network...
November 22, 2016: Annals of Clinical Microbiology and Antimicrobials
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