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https://www.readbyqxmd.com/read/28107679/meta-analysis-of-the-relationship-between-impulsivity-and-substance-related-cognitive-biases
#1
REVIEW
Daniel Leung, Petra K Staiger, Melissa Hayden, Jarrad A G Lum, Kate Hall, Victoria Manning, Antonio Verdejo-Garcia
BACKGROUND: Evidence indicates that substance-related cognitive biases (attentional, memory, and approach bias) contribute to the maintenance and development of substance misuse. Impulsivity has been suggested to influence how cognitive biases contribute to substance misuse, possibly by biasing incentive salience attribution processes. However, the strength and moderators of the relationship between impulsivity and substance-related cognitive biases has yet to be empirically examined...
January 5, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28102506/a-comparison-of-flt-to-fdg-pet-ct-in-the-early-assessment-of-chemotherapy-response-in-stages-ib-iiia-resectable-nsclc
#2
John P Crandall, Abdel K Tahari, Rosalyn A Juergens, Julie R Brahmer, Charles M Rudin, Giuseppe Esposito, Deepa S Subramaniam, Michael V Knopp, Nathan C Hall, Prateek Gajwani, Jeffrey P Leal, Martin A Lodge, Joo H O, Edward W Gabrielson, Lalitha K Shankar, Richard L Wahl
BACKGROUND: The aim of this study was to compare the percentage change in (18)F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 computed tomography (CT) as responders or non-responders after two cycles of therapy. Change in (18)F-fluorodeoxyglucose (FDG) uptake was also compared between these time points. Nine patients with newly diagnosed, operable, non-small cell lung cancer (NSCLC) were imaged with FDG positron emission tomography/CT (PET), FLT PET/CT, and CT at baseline, following one cycle of neoadjuvant therapy (75 mg/m(2) docetaxel + 75 mg/m(2) cisplatin), and again after the second cycle of therapy...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28100307/the-kl24-gene-cluster-and-a-genomic-island-encoding-a-wzy-polymerase-contribute-genes-needed-for-synthesis-of-the-k24-capsular-polysaccharide-by-the-multiply-antibiotic-resistant-acinetobacter-baumannii-isolate-rch51
#3
Johanna J Kenyon, Anastasiya A Kasimova, Mikhail Shneider, Alexander S Shashkov, Nikolay P Arbatsky, Anastasiya V Popova, Konstantin A Miroshnikov, Ruth M Hall, Yuriy A Knirel
The whole genome sequence of the multiply antibiotic resistant Acinetobacter baumannii isolate RCH51 belonging to sequence type ST103 (Institut Pasteur scheme) revealed that the set of genes at the capsule locus, KL24, includes four genes predicted to direct the synthesis of 3-acetamido-3,6-dideoxy-D-galactose (D-Fuc3NAc) and this sugar was found in the capsular polysaccharide (CPS). One of these genes, fdtE, encodes a novel bifunctional protein with an N-terminal FdtA 3,4-ketoisomerase domain and a C-terminal acetyltransferase domain...
January 17, 2017: Microbiology
https://www.readbyqxmd.com/read/28098209/crystal-growth-of-dirac-semimetal-zrsis-with-high-magnetoresistance-and-mobility
#4
Raman Sankar, G Peramaiyan, I Panneer Muthuselvam, Christopher J Butler, Klauss Dimitri, Madhab Neupane, G Narsinga Rao, M-T Lin, F C Chou
High quality single crystal ZrSiS as a theoretically predicted Dirac semimetal has been grown successfully using a vapor phase transport method. The single crystals of tetragonal structure are easy to cleave into perfect square-shaped pieces due to the van der Waals bonding between the sulfur atoms of the quintuple layers. Physical property measurement results including resistivity, Hall coefficient (RH), and specific heat are reported. The transport and thermodynamic properties suggest a Fermi liquid behavior with two Fermi pockets at low temperatures...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096333/biophysical-properties-of-the-clinical-stage-antibody-landscape
#5
Tushar Jain, Tingwan Sun, Stéphanie Durand, Amy Hall, Nga Rewa Houston, Juergen H Nett, Beth Sharkey, Beata Bobrowicz, Isabelle Caffry, Yao Yu, Yuan Cao, Heather Lynaugh, Michael Brown, Hemanta Baruah, Laura T Gray, Eric M Krauland, Yingda Xu, Maximiliano Vásquez, K Dane Wittrup
Antibodies are a highly successful class of biological drugs, with over 50 such molecules approved for therapeutic use and hundreds more currently in clinical development. Improvements in technology for the discovery and optimization of high-potency antibodies have greatly increased the chances for finding binding molecules with desired biological properties; however, achieving drug-like properties at the same time is an additional requirement that is receiving increased attention. In this work, we attempt to quantify the historical limits of acceptability for multiple biophysical metrics of "developability...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095397/a-randomised-phase-ii-trial-and-feasibility-study-of-palliative-chemotherapy-in-frail-or-elderly-patients-with-advanced-gastroesophageal-cancer-321go
#6
P S Hall, S R Lord, M Collinson, H Marshall, M Jones, C Lowe, H Howard, D Swinson, G Velikova, A Anthoney, R Roy, J Dent, S Cheeseman, K Last, M T Seymour
BACKGROUND: Elderly patients are commonly under-represented in cancer clinical trials. The 321GO was undertaken in preparation for a definitive phase three trial assessing different chemotherapy regimens in a frail and/or elderly population with advanced gastroesophageal (GO) cancer. METHODS: Patients with advanced GO cancer considered unfit for conventional dose chemotherapy were randomly assigned in a 1 : 1 : 1 ratio to: epirubicin, oxaliplatin and capecitabine (EOX); oxaliplatin and capecitabine (OX); and capecitabine alone (X) (all 80% of full dose and unblinded)...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28094794/diversity-and-carbon-storage-across-the-tropical-forest-biome
#7
Martin J P Sullivan, Joey Talbot, Simon L Lewis, Oliver L Phillips, Lan Qie, Serge K Begne, Jerôme Chave, Aida Cuni-Sanchez, Wannes Hubau, Gabriela Lopez-Gonzalez, Lera Miles, Abel Monteagudo-Mendoza, Bonaventure Sonké, Terry Sunderland, Hans Ter Steege, Lee J T White, Kofi Affum-Baffoe, Shin-Ichiro Aiba, Everton Cristo de Almeida, Edmar Almeida de Oliveira, Patricia Alvarez-Loayza, Esteban Álvarez Dávila, Ana Andrade, Luiz E O C Aragão, Peter Ashton, Gerardo A Aymard C, Timothy R Baker, Michael Balinga, Lindsay F Banin, Christopher Baraloto, Jean-Francois Bastin, Nicholas Berry, Jan Bogaert, Damien Bonal, Frans Bongers, Roel Brienen, José Luís C Camargo, Carlos Cerón, Victor Chama Moscoso, Eric Chezeaux, Connie J Clark, Álvaro Cogollo Pacheco, James A Comiskey, Fernando Cornejo Valverde, Eurídice N Honorio Coronado, Greta Dargie, Stuart J Davies, Charles De Canniere, Marie Noel Djuikouo K, Jean-Louis Doucet, Terry L Erwin, Javier Silva Espejo, Corneille E N Ewango, Sophie Fauset, Ted R Feldpausch, Rafael Herrera, Martin Gilpin, Emanuel Gloor, Jefferson S Hall, David J Harris, Terese B Hart, Kuswata Kartawinata, Lip Khoon Kho, Kanehiro Kitayama, Susan G W Laurance, William F Laurance, Miguel E Leal, Thomas Lovejoy, Jon C Lovett, Faustin Mpanya Lukasu, Jean-Remy Makana, Yadvinder Malhi, Leandro Maracahipes, Beatriz S Marimon, Ben Hur Marimon Junior, Andrew R Marshall, Paulo S Morandi, John Tshibamba Mukendi, Jaques Mukinzi, Reuben Nilus, Percy Núñez Vargas, Nadir C Pallqui Camacho, Guido Pardo, Marielos Peña-Claros, Pascal Pétronelli, Georgia C Pickavance, Axel Dalberg Poulsen, John R Poulsen, Richard B Primack, Hari Priyadi, Carlos A Quesada, Jan Reitsma, Maxime Réjou-Méchain, Zorayda Restrepo, Ervan Rutishauser, Kamariah Abu Salim, Rafael P Salomão, Ismayadi Samsoedin, Douglas Sheil, Rodrigo Sierra, Marcos Silveira, J W Ferry Slik, Lisa Steel, Hermann Taedoumg, Sylvester Tan, John W Terborgh, Sean C Thomas, Marisol Toledo, Peter M Umunay, Luis Valenzuela Gamarra, Ima Célia Guimarães Vieira, Vincent A Vos, Ophelia Wang, Simon Willcock, Lise Zemagho
Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation strategies needed to achieve these two functions depend critically on the tropical forest tree diversity-carbon storage relationship. Assessing this relationship is challenging due to the scarcity of inventories where carbon stocks in aboveground biomass and species identifications have been simultaneously and robustly quantified...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093703/african-american-and-caribbean-born-men-s-perceptions-of-prostate-cancer-fear-and-facilitators-for-screening-behavior-a-pilot-study
#8
Ewan K Cobran, Jori N Hall, William D Aiken
This study describes how a concurrent exploratory mixed methodology (CEMM) approach was used to investigate perceptions of prostate cancer (CaP) fear and facilitators of screening behavior in African-American (AA) and Caribbean-born (CB) black men for instrument development. A quantitative paper-based questionnaire was modified, adapted, and administered to participants from the Personal Integrative Model of Prostate Cancer Disparity Survey and the Powe Fatalism Inventory. Focus groups and individual interviews were conducted and analyzed using thematic analysis...
January 16, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28089567/adipose-tissue-clk2-promotes-energy-expenditure-during-high-fat-diet-intermittent-fasting
#9
Maximilian Hatting, Amy K Rines, Chi Luo, Mitsuhisa Tabata, Kfir Sharabi, Jessica A Hall, Francisco Verdeguer, Christian Trautwein, Pere Puigserver
A promising approach to treating obesity is to increase diet-induced thermogenesis in brown adipose tissue (BAT), but the regulation of this process remains unclear. Here we find that CDC-like kinase 2 (CLK2) is expressed in BAT and upregulated upon refeeding. Mice lacking CLK2 in adipose tissue exhibit exacerbated obesity and decreased energy expenditure during high-fat diet intermittent fasting. Additionally, tissue oxygen consumption and protein levels of UCP1 are reduced in CLK2-deficient BAT. Phosphorylation of CREB, a transcriptional activator of UCP1, is markedly decreased in BAT cells lacking CLK2 due to enhanced CREB dephosphorylation...
January 11, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28089481/recommendations-for-mri-based-contouring-of-gross-tumor-volume-and-organs-at-risk-for-radiation-therapy-of-pancreatic-cancer
#10
H D Heerkens, W A Hall, X A Li, P Knechtges, E Dalah, E S Paulson, C A T van den Berg, G J Meijer, E J Koay, C H Crane, K Aitken, M van Vulpen, B A Erickson
PURPOSE: Local recurrence is a common and morbid event in patients with unresectable pancreatic adenocarcinoma. A more conformal and targeted radiation dose to the macroscopic tumor in nonmetastatic pancreatic cancer is likely to reduce acute toxicity and improve local control. Optimal soft tissue contrast is required to facilitate delineation of a target and creation of a planning target volume with margin reduction and motion management. Magnetic resonance imaging (MRI) offers considerable advantages in optimizing soft tissue delineation and is an ideal modality for imaging and delineating a gross tumor volume (GTV) within the pancreas, particularly as it relates to conformal radiation planning...
October 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28075535/response-to-smith-and-brogly-et-al-commentaries-on-zedler-et-al
#11
Andrew R Joyce, Barbara K Zedler, Halle R Amick, E Lenn Murrelle, Hendree E Jones
No abstract text is available yet for this article.
December 2016: Addiction
https://www.readbyqxmd.com/read/28074888/a-review-of-the-carbohydrate-insulin-model-of-obesity
#12
REVIEW
K D Hall
The carbohydrate-insulin model of obesity theorizes that diets high in carbohydrate are particularly fattening due to their propensity to elevate insulin secretion. Insulin directs the partitioning of energy toward storage as fat in adipose tissue and away from oxidation by metabolically active tissues and purportedly results in a perceived state of cellular internal starvation. In response, hunger and appetite increases and metabolism is suppressed, thereby promoting the positive energy balance associated with the development of obesity...
January 11, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28069737/mtorc1-plays-an-important-role-in-skeletal-development-by-controlling-pre-osteoblast-differentiation
#13
Stephen Fitter, Mary P Matthews, Sally K Martin, Jianling Xie, Soo Siang Ooi, Carl R Walkley, John D Codrington, Markus A Ruegg, Michael N Hall, Christopher G Proud, Stan Gronthos, Andrew C W Zannettino
The mammalian target of rapamycin complex 1 (mTORC1) is activated by extracellular factors that control bone accrual. However, the direct role of this complex in osteoblast biology remains to be determined. To investigate this question, we disrupted mTORC1 function in pre-osteoblasts by targeted deletion of Raptor (Rptor) in Osterix-expressing cells. Deletion of Rptor resulted in reduced limb length that was associated with smaller epiphyseal growth plates in the postnatal skeleton. Rptor deletion caused a marked reduction in pre- and post-natal bone accrual, which was evident in skeletal elements derived from both intramembranous and endochondrial ossification...
January 9, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28068484/informatics-and-data-analytics-to-support-exposome-based-discovery-for-public-health
#14
Arjun K Manrai, Yuxia Cui, Pierre R Bushel, Molly Hall, Spyros Karakitsios, Carolyn J Mattingly, Marylyn Ritchie, Charles Schmitt, Denis A Sarigiannis, Duncan C Thomas, David Wishart, David M Balshaw, Chirag J Patel
The complexity of the human exposome-the totality of environmental exposures encountered from birth to death-motivates systematic, high-throughput approaches to discover the environmental determinants of disease. In this review, we describe the state of science in analyzing the human exposome and provide recommendations for the public health community to consider in dealing with analytic challenges of exposome-based biomedical research. We describe extant and novel analytic methods needed to associate the exposome with critical health outcomes and contextualize the data-centered challenges by drawing parallels to other research endeavors such as human genomics research...
December 23, 2016: Annual Review of Public Health
https://www.readbyqxmd.com/read/28067909/smchd1-mutations-associated-with-a-rare-muscular-dystrophy-can-also-cause-isolated-arhinia-and-bosma-arhinia-microphthalmia-syndrome
#15
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-Ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders...
January 9, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28067306/coexistence-of-topological-dirac-fermions-on-the-surface-and-three-dimensional-dirac-cone-state-in-the-bulk-of-zrte5-single-crystal
#16
Arnab Pariari, Prabhat Mandal
Although, the long-standing debate on the resistivity anomaly in ZrTe5 somewhat comes to an end, the exact topological nature of the electronic band structure remains elusive till today. Theoretical calculations predicted that bulk ZrTe5 to be either a weak or a strong three-dimensional (3D) topological insulator. However, the angle resolved photoemission spectroscopy and transport measurements clearly demonstrate 3D Dirac cone state with a small mass gap between the valence band and conduction band in the bulk...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065205/australia-s-national-notifiable-diseases-surveillance-system-1991-2011-expanding-adapting-and-improving
#17
K B Gibney, A C Cheng, R Hall, K Leder
We reviewed key attributes (flexibility, data quality and timeliness) of Australia's National Notifiable Diseases Surveillance System (NNDSS) over its first 21 years. Cases notified to NNDSS from 1991 to 2011 were examined by jurisdiction (six states and two territories) and sub-period to describe changes in the number of notifiable diseases, proportion of cases diagnosed using PCR tests, data quality (focusing on data completeness), and notification delays. The number of notifiable diseases increased from 37 to 65...
January 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28061039/long-term-breastfeeding-in-african-american-mothers
#18
Tyra Toston Gross, Marsha Davis, Alex K Anderson, Jori Hall, Karen Hilyard
BACKGROUND: According to the Centers for Disease Control and Prevention, 39.1% of African American infants are breastfed at 6 months. However, few studies have explored the breastfeeding experiences of African American women who successfully breastfeed to 6 months or longer durations. Research aim: The goal of this qualitative study was to explore the long-term breastfeeding experiences of low-income African American women using the positive deviance approach. METHODS: African American women with breastfeeding experience were recruited through Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) breastfeeding peer counselors...
December 1, 2016: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28059694/visualization-approaches-to-support-healthy-aging-a-systematic-review
#19
Uba Backonja, Nai-Ching Chi, Yong Choi, Amanda K Hall, Thai Le, Youjeong Kang, George Demiris
BACKGROUND: Health technologies have the potential to support the growing number of older adults who are aging in place. Many tools include visualizations (data visualizations, visualizations of physical representations). However, the role of visualizations in supporting aging in place remains largely unexplored. OBJECTIVE: To synthesize and identify gaps in the literature evaluating visualizations (data visualizations and visualizations of physical representations), for informatics tools to support healthy aging...
October 10, 2016: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28059549/rosenbluth-separation-of-the-%C3%AF-0-electroproduction-cross-section
#20
M Defurne, M Mazouz, Z Ahmed, H Albataineh, K Allada, K A Aniol, V Bellini, M Benali, W Boeglin, P Bertin, M Brossard, A Camsonne, M Canan, S Chandavar, C Chen, J-P Chen, C W de Jager, R de Leo, C Desnault, A Deur, L El Fassi, R Ent, D Flay, M Friend, E Fuchey, S Frullani, F Garibaldi, D Gaskell, A Giusa, O Glamazdin, S Golge, J Gomez, O Hansen, D Higinbotham, T Holmstrom, T Horn, J Huang, M Huang, G M Huber, C E Hyde, S Iqbal, F Itard, Ho Kang, Hy Kang, A Kelleher, C Keppel, S Koirala, I Korover, J J LeRose, R Lindgren, E Long, M Magne, J Mammei, D J Margaziotis, P Markowitz, A Martí Jiménez-Argüello, F Meddi, D Meekins, R Michaels, M Mihovilovic, N Muangma, C Muñoz Camacho, P Nadel-Turonski, N Nuruzzaman, R Paremuzyan, A Puckett, V Punjabi, Y Qiang, A Rakhman, M N H Rashad, S Riordan, J Roche, G Russo, F Sabatié, K Saenboonruang, A Saha, B Sawatzky, L Selvy, A Shahinyan, S Sirca, P Solvignon, M L Sperduto, R Subedi, V Sulkosky, C Sutera, W A Tobias, G M Urciuoli, D Wang, B Wojtsekhowski, H Yao, Z Ye, L Zana, X Zhan, J Zhang, B Zhao, Z Zhao, X Zheng, P Zhu
We present deeply virtual π^{0} electroproduction cross-section measurements at x_{B}=0.36 and three different Q^{2} values ranging from 1.5 to 2  GeV^{2}, obtained from Jefferson Lab Hall A experiment E07-007. The Rosenbluth technique is used to separate the longitudinal and transverse responses. Results demonstrate that the cross section is dominated by its transverse component and, thus, is far from the asymptotic limit predicted by perturbative quantum chromodynamics. Nonetheless, an indication of a nonzero longitudinal contribution is provided by the measured interference term σ_{LT}...
December 23, 2016: Physical Review Letters
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