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https://www.readbyqxmd.com/read/28934365/murine-glomerular-transcriptome-links-endothelial-cell-specific-molecule-1-deficiency-with-susceptibility-to-diabetic-nephropathy
#1
Xiaoyi Zheng, Fariborz Soroush, Jin Long, Evan T Hall, Puneeth K Adishesha, Sanchita Bhattacharya, Mohammad F Kiani, Vivek Bhalla
Diabetic nephropathy (DN) is the leading cause of kidney disease; however, there are no early biomarkers and no cure. Thus, there is a large unmet need to predict which individuals will develop nephropathy and to understand the molecular mechanisms that govern this susceptibility. We compared the glomerular transcriptome from mice with distinct susceptibilities to DN at four weeks after induction of diabetes, but before histologic injury, and identified differential regulation of genes that modulate inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/28933427/tunable-interacting-composite-fermion-phases-in-a-half-filled-bilayer-graphene-landau-level
#2
A A Zibrov, C Kometter, H Zhou, E M Spanton, T Taniguchi, K Watanabe, M P Zaletel, A F Young
Non-Abelian anyons are a type of quasiparticle with the potential to encode quantum information in topological qubits protected from decoherence. Experimental systems that are predicted to harbour non-Abelian anyons include p-wave superfluids, superconducting systems with strong spin-orbit coupling, and paired states of interacting composite fermions that emerge at even denominators in the fractional quantum Hall (FQH) regime. Although even-denominator FQH states have been observed in several two-dimensional systems, small energy gaps and limited tunability have stymied definitive experimental probes of their non-Abelian nature...
September 20, 2017: Nature
https://www.readbyqxmd.com/read/28931761/periodontal-induced-chronic-inflammation-triggers-macrophage-secretion-of-ccl12-to-inhibit-fibroblast-mediated-cardiac-wound-healing
#3
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Osasere K Ero, Courtney A Cates, Elizabeth R Flynn, Presley L Cannon, Mira Jung, De'Aries Shannon, Michael R Garrett, William Buchanan, Michael E Hall, Yonggang Ma, Merry L Lindsey
Chronic inflammatory diseases, such as periodontal disease, associate with adverse wound healing in response to myocardial infarction (MI). The goal of this study was to elucidate the molecular basis for impaired cardiac wound healing in the setting of periodontal-induced chronic inflammation. Causal network analysis of 168 inflammatory and extracellular matrix genes revealed that chronic inflammation induced by a subseptic dose of Porphyromonas gingivalis lipopolysaccharide (LPS) exacerbated infarct expression of the proinflammatory cytokine Ccl12...
September 21, 2017: JCI Insight
https://www.readbyqxmd.com/read/28929972/abstracts-from-hydrocephalus-2016
#4
A Adam, J Robison, J Lu, R Jose, N Badran, T Vivas-Buitrago, D Rigamonti, A Sattar, O Omoush, M Hammad, M Dawood, M Maghaslah, T Belcher, K Carson, J Hoffberger, I Jusué Torres, S Foley, S Yasar, Q A Thai, J Wemmer, P Klinge, L Al-Mutawa, H Al-Ghamdi, K A Carson, M Asgari, D de Zélicourt, V Kurtcuoglu, S Garnotel, S Salmon, O Balédent, A Lokossou, G Page, L Balardy, Z Czosnyka, P Payoux, E A Schmidt, M Zitoun, M A Sevestre, N Alperin, I Baudracco, C Craven, S Matloob, S Thompson, P Haylock Vize, L Thorne, L D Watkins, A K Toma, Karl Bechter, A C Pong, L Jugé, L E Bilston, S Cheng, W Bradley, F Hakim, J F Ramón, M F Cárdenas, J S Davidson, C García, D González, S Bermúdez, N Useche, J A Mejía, P Mayorga, F Cruz, C Martinez, M C Matiz, M Vallejo, K Ghotme, H A Soto, D Riveros, A Buitrago, M Mora, L Murcia, S Bermudez, D Cohen, D Dasgupta, C Curtis, L Domínguez, A J Remolina, M A Grijalba, K J Whitehouse, R J Edwards, A Eleftheriou, F Lundin, K N Fountas, E Z Kapsalaki, H F Smisson, J S Robinson, M J Fritsch, W Arouk, M Garzon, M Kang, K Sandhu, D Baghawatti, K Aquilina, G James, D Thompson, M Gehlen, M Schmid Daners, A Eklund, J Malm, D Gomez, M Guerra, M Jara, M Flores, K Vío, I Moreno, S Rodríguez, E Ortega, E M Rodríguez, J P McAllister, M M Guerra, D M Morales, D Sival, A Jimenez, D D Limbrick, M Ishikawa, S Yamada, K Yamamoto, A Junkkari, A Häyrinen, T Rauramaa, H Sintonen, O Nerg, A M Koivisto, R P Roine, H Viinamäki, H Soininen, A Luikku, J E Jääskeläinen, V Leinonen, U Kehler, O Lilja-Lund, K Kockum, E M Larsson, K Riklund, L Söderström, P Hellström, K Laurell, M Kojoukhova, A Sutela, R Vanninen, K I Vanha, M Timonen, J Rummukainen, V Korhonen, S Helisalmi, E Solje, A M Remes, J Huovinen, J Paananen, M Hiltunen, M Kurki, B Martin, F Loth, M Luciano, A J Luikku, A Hall, S K Herukka, J Mattila, J Lötjönen, I Alafuzoff, I Jurjević, M Miyajima, M Nakajima, H Murai, T Shin, D Kawaguchi, C Akiba, I Ogino, K Karagiozov, H Arai, R C Reis, M J Teixeira, C G Valêncio, D da Vigua, L Almeida-Lopes, M W Mancini, F C G Pinto, R H Maykot, G Calia, J Tornai, S S S Silvestre, G Mendes, V Sousa, B Bezerra, P Dutra, P Modesto, M F Oliveira, C E Petitto, H Pulhorn, A Chandran, C McMahon, A S Rao, M Jumaly, D Solomon, A Moghekar, N Relkin, M Hamilton, H Katzen, M Williams, T Bach, S Zuspan, R Holubkov, A Rigamonti, G Clemens, P Sharkey, A Sanyal, E Sankey, K Rigamonti, S Naqvi, A Hung, E Schmidt, F Ory-Magne, P Gantet, A Guenego, A C Januel, P Tall, N Fabre, L Mahieu, C Cognard, L Gray, J A Buttner-Ennever, K Takagi, K Onouchi, S D Thompson, L D Thorne, H M Tully, T L Wenger, W A Kukull, D Doherty, W B Dobyns, D Moran, S Vakili, M A Patel, B Elder, C R Goodwin, J A Crawford, M V Pletnikov, J Xu, A Blitz, D A Herzka, H Guerrero-Cazares, A Quiñones-Hinojosa, S Mori, P Saavedra, H Treviño, K Maitani, W C Ziai, V Eslami, S Nekoovaght-Tak, R Dlugash, G Yenokyan, N McBee, D F Hanley
No abstract text is available yet for this article.
June 7, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28928485/increased-trem-2-expression-on-the-subsets-of-cd11c-cells-in-the-lungs-and-lymph-nodes-during-allergic-airway-inflammation
#5
Sannette C Hall, Devendra K Agrawal
Dendritic cells (DCs) are professional APCs that traffic to the draining lymph nodes where they present processed antigens to naïve T-cells. The recently discovered triggering receptor expressed on myeloid cells (TREM)-2 has been shown to be expressed on DCs in several disease models, however, its role in asthma is yet to be elucidated. In the present study, we examined the effect of allergen exposure on TREM-2 expression in the airways and on DC subsets in the lung and lymph nodes in murine model of allergic airway inflammation...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927900/expression-of-glucocorticoid-receptor-is-associated-with-aggressive-primary-endometrial-cancer-and-increases-from-primary-to-metastatic-lesions
#6
Ingvild L Tangen, Jennifer Taylor Veneris, Mari K Halle, Henrica M Werner, Jone Trovik, Lars A Akslen, Helga B Salvesen, Suzanne D Conzen, Gini F Fleming, Camilla Krakstad
BACKGROUND: Glucocorticoid receptor (GR) has emerged as an important steroid nuclear receptor in hormone dependent cancers, however few data are available regarding a potential role of GR in endometrial cancer. The aim of this study was to investigate expression of GR in primary and metastatic endometrial cancer lesions, and to assess the relationship between GR expression and clinical and histopathological variables and survival. METHODS: Expression of GR was investigated by IHC in 724 primary tumors and 289 metastatic lesions (from 135 patients), and correlations with clinical and histopathological data and survival were explored...
September 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28924301/epitaxial-graphene-homogeneity-and-quantum-hall-effect-in-millimeter-scale-devices
#7
Yanfei Yang, Guangjun Cheng, Patrick Mende, Irene G Calizo, Randall M Feenstra, Chiashain Chuang, Chieh-Wen Liu, Chieh-I Liu, George R Jones, Angela R Hight Walker, Randolph E Elmquist
Quantized magnetotransport is observed in 5.6 × 5.6 mm(2) epitaxial graphene devices, grown using highly constrained sublimation on the Si-face of SiC(0001) at high temperature (1900 °C). The precise quantized Hall resistance of [Formula: see text] is maintained up to record level of critical current Ixx = 0.72 mA at T = 3.1 K and 9 T in a device where Raman microscopy reveals low and homogeneous strain. Adsorption-induced molecular doping in a second device reduced the carrier concentration close to the Dirac point (n ≈ 10(10) cm(-2)), where mobility of 18760 cm(2)/V is measured over an area of 10 mm(2)...
May 2017: Carbon
https://www.readbyqxmd.com/read/28923974/manipulation-of-ionized-impurity-scattering-for-achieving-high-thermoelectric-performance-in-n-type-mg3sb2-based-materials
#8
Jun Mao, Jing Shuai, Shaowei Song, Yixuan Wu, Rebecca Dally, Jiawei Zhou, Zihang Liu, Jifeng Sun, Qinyong Zhang, Clarina Dela Cruz, Stephen Wilson, Yanzhong Pei, David J Singh, Gang Chen, Ching-Wu Chu, Zhifeng Ren
Achieving higher carrier mobility plays a pivotal role for obtaining potentially high thermoelectric performance. In principle, the carrier mobility is governed by the band structure as well as by the carrier scattering mechanism. Here, we demonstrate that by manipulating the carrier scattering mechanism in n-type Mg3Sb2-based materials, a substantial improvement in carrier mobility, and hence the power factor, can be achieved. In this work, Fe, Co, Hf, and Ta are doped on the Mg site of Mg3.2Sb1.5Bi0.49Te0...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923582/glaucoma-following-corneal-replacement
#9
REVIEW
Monika Baltaziak, Hall F Chew, Dominik W Podbielski, Iqbal Ike K Ahmed
Glaucoma is a well-known complication following corneal transplantation surgery. Traditional corneal transplantation surgery, specifically penetrating keratoplasty (PK), has been slowly replaced by the advent of new corneal transplantation procedures: primarily lamellar keratoplasties. There has also been an emergence of keratoprosthesis implants for eyes that are high risk of failure with PK. Consequently, there are different rates of glaucoma, pathogenesis, and potential treatment in the form of medical, laser or surgical therapy...
September 16, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28923317/calcified-cartilage-or-bone-collagens-in-the-tessellated-endoskeletons-of-cartilaginous-fish-sharks-and-rays
#10
Ronald Seidel, Michael Blumer, Elisabeth-Judith Pechriggl, Kady Lyons, Brian K Hall, Peter Fratzl, James C Weaver, Mason N Dean
The primary skeletal tissue in elasmobranchs -sharks, rays and relatives- is cartilage, forming both embryonic and adult endoskeletons. Only the skeletal surface calcifies, exhibiting mineralized tiles (tesserae) sandwiched between a cartilage core and overlying fibrous perichondrium. These two tissues are based on different collagens (Coll II and I, respectively), fueling a long-standing debate as to whether tesserae are more like bone (Coll 1-based) or calcified cartilage in their matrix composition. We demonstrate that stingray (Urobatis halleri) tesserae are bipartite, having an upper Coll I-based "cap" that merges into a lower Coll II-based "body" zone, although tesserae are surrounded by cartilage...
September 15, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28921764/acanthamoeba-granulomatous-amoebic-encephalitis-after-pediatric-hematopoietic-stem-cell-transplant
#11
Scott L Coven, Eunkyung Song, Sarah Steward, Christopher R Pierson, Jennifer R Cope, Ibne K Ali, Monica I Ardura, Mark W Hall, Melissa G Chung, Rajinder P S Bajwa
Acanthamoeba encephalitis is a rare, often fatal condition, particularly after HSCT, with 9 reported cases to date in the world literature. Our case was originally diagnosed with ALL at age 3 years, and after several relapses underwent HSCT at age 9 years. At 17 years of age, he was diagnosed with secondary AML for which he underwent a second allogeneic HSCT. He presented with acute-onset worsening neurological deficits on day +226 after the second transplant and a post-mortem diagnosis of Acanthamoeba encephalitis was established, with the aid of the CDC...
September 17, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28921739/a-rapid-review-of-needs-assessment-tools-for-post-treatment-cancer-survivors
#12
REVIEW
M Jiao, A E Hall, L Nolte, A Piper, K Lisy, M Jefford
Relevant, comprehensive and psychometrically rigorous needs assessment tools are needed to ensure appropriate care is delivered to cancer survivors who have completed treatment. The aim of this rapid review was to identify and describe needs assessment tools that are used in cancer survivors post-treatment, assess their psychometric properties and describe their use in clinical care. The electronic databases Medline, Cochrane Library, CINAHL and PsycINFO were searched. Six studies were identified that described five needs assessment tools used in cancer survivors post-treatment...
September 18, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28921014/-legal-medicine-specialists-within-the-framework-of-acute-care-analysis-of-legal-medicine-consultations-in-relation-to-the-victims-statistics-of-the-state-office-of-criminal-investigation-in-saxony-anhalt
#13
G Pliske, S Heide, B Lucas, K Brandstädter, F Walcher, S Kropf, R Lessig, S Piatek
BACKGROUND: In acute medical care, there are patients who have been injured by the influence of others. The aim of this study was to analyze all cases which were presented to the Institute for Legal Medicine of the University Halle (Saale). The cases where analyzed in relation to the victims' statistics of the state office of criminal investigation in Saxony-Anhalt. MATERIALS AND METHODS: The consultations of the Institute for Legal Medicine Halle-Wittenberg for 2012-2015 were evaluated with regard to the age and gender distribution, the reasons for the consultation and time until the request for consultations...
September 18, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28916812/size-dependent-electrical-transport-properties-in-co-nanocluster-assembled-granular-films
#14
Q F Zhang, X Z Wang, L S Wang, H F Zheng, L Lin, J Xie, X Liu, Y L Qiu, Y Z Chen, D L Peng
A series of Co nanocluster-assembled films with cluster sizes ranging from 4.5 nm to 14.7 nm were prepared by the plasma-gas-condensation method. The size-dependent electrical transport properties were systematically investigated. Both of the longitudinal resistivity ([Formula: see text]) and saturated anomalous Hall resistivity ([Formula: see text]) continuously increased with the decrease of the cluster sizes (d). The [Formula: see text] firstly increased and then decreased with increasing the temperature for all samples, which could be well described by involving the thermally fluctuation-induced tunneling (FIT) process and scattering...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28911065/development-of-an-integrated-electronic-platform-for-patient-self-report-and-management-of-adverse-events-during-cancer-treatment
#15
P Holch, L Warrington, L C A Bamforth, A Keding, L E Ziegler, K Absolom, C Hector, C Harley, O Johnson, G Hall, C Morris, G Velikova
Background: Significant adverse events (AE) during cancer therapy disrupt treatment and escalate to emergency admissions. Approaches to improve the timeliness and accuracy of AE reporting may improve safety and reduce health service costs. Reporting AE via patient reported outcomes (PROs), can improve clinician-patient communication and making data available to clinicians in 'real-time' using electronic PROs (ePROs) could potentially transform clinical practice by providing easily accessible records to guide treatment decisions...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28904224/targeted-inhibition-of-gq-signaling-induces-airway-relaxation-in-mouse-models-of-asthma
#16
Michaela Matthey, Richard Roberts, Alexander Seidinger, Annika Simon, Ralf Schröder, Markus Kuschak, Suvi Annala, Gabriele M König, Christa E Müller, Ian P Hall, Evi Kostenis, Bernd K Fleischmann, Daniela Wenzel
Obstructive lung diseases are common causes of disability and death worldwide. A hallmark feature is aberrant activation of Gq protein-dependent signaling cascades. Currently, drugs targeting single G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors (GPCRs) are used to reduce airway tone. However, therapeutic efficacy is often limited, because various GPCRs contribute to bronchoconstriction, and chronic exposure to receptor-activating medications results in desensitization. We therefore hypothesized that pharmacological Gq inhibition could serve as a central mechanism to achieve efficient therapeutic bronchorelaxation...
September 13, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28895690/instrument-to-assess-educational-programs-for-parents-of-children-with-congenital-heart-disease-undergoing-cardiac-surgery
#17
Paola Pino Armijo, Muriel Ramírez León, Cristian Clavería Rodríguez
OBJETIVE: To design and validate an instrument to assess the relevance of educational programs for parents of children with congenital heart disease (CHD) undergoing cardiac surgery. MATERIAL AND METHOD: In October 2011, an instrument was designed based on Kaufman's model and on the bibliography, and a survey was developed in the form of a checklist with 32 close-ended questions about received education and desired education, categorized into 5 items: educator, time, place, means, and content...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28895452/debunking-a-meta-analysis-of-the-psychological-efficacy-of-messages-countering-misinformation
#18
Man-Pui Sally Chan, Christopher R Jones, Kathleen Hall Jamieson, Dolores Albarracín
This meta-analysis investigated the factors underlying effective messages to counter attitudes and beliefs based on misinformation. Because misinformation can lead to poor decisions about consequential matters and is persistent and difficult to correct, debunking it is an important scientific and public-policy goal. This meta-analysis ( k = 52, N = 6,878) revealed large effects for presenting misinformation ( ds = 2.41-3.08), debunking ( ds = 1.14-1.33), and the persistence of misinformation in the face of debunking ( ds = 0...
September 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28895395/thermoelectric-properties-of-sns-with-na-doping
#19
Binqiang Zhou, Shuai Li, Wen Li, Juan Li, Xinyue Zhang, Siqi Lin, Zhiwei Chen, Yanzhong Pei
Tin sulfide (SnS), a low-cost compound from the IV-VI semiconductors, has attracted particular attention due to its great potential for large-scale thermoelectric applications. However, pristine SnS shows a low carrier concentration, which leads to a low thermoelectric performance. In this work, sodium is utilized to substitute Sn to increase the hole concentration and consequently improve the thermoelectric power factor. The resultant Hall carrier concentration up to ∼10(19) cm(-3) is the highest concentration reported so far for this compound...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28892606/crispr-mediated-tagging-of-endogenous-proteins-with-a-luminescent-peptide
#20
Marie K Schwinn, Thomas Machleidt, Kris Zimmerman, Christopher T Eggers, Andrew S Dixon, Robin Hurst, Mary P Hall, Lance P Encell, Brock F Binkowski, Keith V Wood
Intracellular signaling pathways are mediated by changes in protein abundance and post-translational modifications. A common approach for investigating intracellular signaling and the effects induced by synthetic compounds is to overexpress recombinant reporter genes within a cell. Genome editing with CRISPR/Cas9 offers a means to better preserve native biology by appending reporters directly onto the endogenous genes. An optimal reporter for this purpose would be small to negligibly influence intracellular processes, be readily linked to the endogenous genes with minimal experimental effort, and be sensitive enough to detect low expressing proteins...
September 11, 2017: ACS Chemical Biology
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