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https://www.readbyqxmd.com/read/29782621/darpp-32-and-t-darpp-promote-non-small-cell-lung-cancer-growth-through-regulation-of-ikk%C3%AE-dependent-cell-migration
#1
Sk Kayum Alam, Matteo Astone, Ping Liu, Stephanie R Hall, Abbygail M Coyle, Erin N Dankert, Dane K Hoffman, Wei Zhang, Rui Kuang, Anja C Roden, Aaron S Mansfield, Luke H Hoeppner
Lung cancer is the leading cause of cancer-related death worldwide. Here we demonstrate that elevated expression of dopamine and cyclic adenosine monophosphate-regulated phosphoprotein, Mr 32000 (DARPP-32) and its truncated splice variant t-DARPP promote lung tumor growth, while abrogation of DARPP-32 expression in human non-small cell lung cancer (NSCLC) cells reduces tumor growth in orthotopic mouse models. We observe a novel physical interaction between DARPP-32 and inhibitory kappa B kinase-α (IKKα) that promotes NSCLC cell migration through non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NF-κB2) signaling...
2018: Commun Biol
https://www.readbyqxmd.com/read/29775457/potassium-and-sodium-microdomains-in-thin-astroglial-processes-a-computational-model-study
#2
Kevin Breslin, John Joseph Wade, KongFatt Wong-Lin, Jim Harkin, Bronac Flanagan, Harm Van Zalinge, Steve Hall, Matthew Walker, Alexei Verkhratsky, Liam McDaid
A biophysical model that captures molecular homeostatic control of ions at the perisynaptic cradle (PsC) is of fundamental importance for understanding the interplay between astroglial and neuronal compartments. In this paper, we develop a multi-compartmental mathematical model which proposes a novel mechanism whereby the flow of cations in thin processes is restricted due to negatively charged membrane lipids which result in the formation of deep potential wells near the dipole heads. These wells restrict the flow of cations to "hopping" between adjacent wells as they transverse the process, and this surface retention of cations will be shown to give rise to the formation of potassium (K+) and sodium (Na+) microdomains at the PsC...
May 18, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29775347/dirac-and-chiral-quantum-spin-liquids-on-the-honeycomb-lattice-in-a-magnetic-field
#3
Zheng-Xin Liu, B Normand
Motivated by recent experimental observations in α-RuCl_{3}, we study the K-Γ model on the honeycomb lattice in an external magnetic field. By a slave-particle representation and variational Monte Carlo calculations, we reproduce the phase transition from zigzag magnetic order to a field-induced disordered phase. The nature of this state depends crucially on the field orientation. For particular field directions in the honeycomb plane, we find a gapless Dirac spin liquid, in agreement with recent experiments on α-RuCl_{3}...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774918/proximity-induced-magnetism-and-an-anomalous-hall-effect-in-bi-2-se-3-lacoo-3-a-topological-insulator-ferromagnetic-insulator-thin-film-heterostructure
#4
Shanna Zhu, Dechao Meng, Genhao Liang, Gang Shi, Peng Zhao, Peng Cheng, Yongqing Li, Xiaofang Zhai, Yalin Lu, Lan Chen, Kehui Wu
Inducing magnetism in a topological insulator (TI) by exchange coupling with a ferromagnetic insulator (FMI) will break the time-reversal symmetry of topological surface states, offering possibilities to realize several predicted novel magneto-electric effects. Seeking suitable FMI materials is crucial for the coupling of heterojunctions, and yet is challenging as well and only a few kinds have been explored. In this report, we introduce epitaxial LaCoO3 thin films on a SrTiO3 substrate, which is an insulating ferromagnet with a Curie temperature of TC ∼ 85 K, to be combined with TIs for proximity coupling...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29767574/right-ventricular-stroke-work-correlates-with-outcomes-in-pediatric-pulmonary-arterial-hypertension
#5
Weiguang Yang, Alison L Marsden, Michelle T Ogawa, Charlotte Sakarovitch, Keeley K Hall, Marlene Rabinovitch, Jeffrey A Feinstein
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
https://www.readbyqxmd.com/read/29765027/polygenic-pleiotropy-and-potential-causal-relationships-between-educational-attainment-neurobiological-profile-and-positive-psychotic-symptoms
#6
Yen-Feng Lin, Chia-Yen Chen, Dost Öngür, Rebecca Betensky, Jordan W Smoller, Deborah Blacker, Mei-Hua Hall
Event-related potential (ERP) components have been used to assess cognitive functions in patients with psychotic illness. Evidence suggests that among patients with psychosis there is a distinct heritable neurophysiologic phenotypic subtype captured by impairments across a range of ERP measures. In this study, we investigated the genetic basis of this "globally impaired" ERP cluster and its relationship to psychosis and cognitive abilities. We applied K-means clustering to six ERP measures to re-derive the globally impaired (n = 60) and the non-globally impaired ERP clusters (n = 323) in a sample of cases with schizophrenia (SCZ = 136) or bipolar disorder (BPD = 121) and healthy controls (n = 126)...
May 16, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29758589/spindle-cell-rhabdomyosarcoma-of-bone-with-fus-tfcp2-fusion-confirmation-of-a-very-recently-described-rhabdomyosarcoma-subtype
#7
Nooshin K Dashti, Rebecca N Wehrs, Brittany C Thomas, Asha Nair, Jaime Davila, Jan C Buckner, Anthony P Martinez, William R Sukov, Kevin C Halling, Benjamin M Howe, Andrew L Folpe
AIMS: Rhabdomyosarcomas of bone are extremely rare, with fewer than 10 reported cases. A very rare subtype of spindle cell/sclerosing rhabdomyosarcoma harboring a FUS-TFCP2 fusion and involving both soft tissue and bone locations has very recently been reported. We report only the fourth case of this unusual, clinically aggressive rhabdomyosarcoma. MATERIAL AND RESULTS: A previously-well 72-year old male presented with a destructive lesion of the mandible. Morphological and immunohistochemical study of a needle biopsy and the subsequent resection showed a spindle cell rhabdomyosarcoma...
May 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29748316/common-and-rare-coding-genetic-variation-underlying-the-electrocardiographic-pr-interval
#8
Honghuang Lin, Jessica van Setten, Albert V Smith, Nathan A Bihlmeyer, Helen R Warren, Jennifer A Brody, Farid Radmanesh, Leanne Hall, Niels Grarup, Martina Müller-Nurasyid, Thibaud Boutin, Niek Verweij, Henry J Lin, Ruifang Li-Gao, Marten E van den Berg, Jonathan Marten, Stefan Weiss, Bram P Prins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Hao Mei, Tamara B Harris, Lenore J Launer, Man Li, Alvaro Alonso, Elsayed Z Soliman, John M Connell, Paul L Huang, Lu-Chen Weng, Heather S Jameson, William Hucker, Alan Hanley, Nathan R Tucker, Yii-Der Ida Chen, Joshua C Bis, Kenneth M Rice, Colleen M Sitlani, Jan A Kors, Zhijun Xie, Chengping Wen, Jared W Magnani, Christopher P Nelson, Jørgen K Kanters, Moritz F Sinner, Konstantin Strauch, Annette Peters, Melanie Waldenberger, Thomas Meitinger, Jette Bork-Jensen, Oluf Pedersen, Allan Linneberg, Igor Rudan, Rudolf A de Boer, Peter van der Meer, Jie Yao, Xiuqing Guo, Kent D Taylor, Nona Sotoodehnia, Jerome I Rotter, Dennis O Mook-Kanamori, Stella Trompet, Fernando Rivadeneira, André Uitterlinden, Mark Eijgelsheim, Sandosh Padmanabhan, Blair H Smith, Henry Völzke, Stephan B Felix, Georg Homuth, Uwe Völker, Massimo Mangino, Timothy D Spector, Michiel L Bots, Marco Perez, Mika Kähönen, Olli T Raitakari, Vilmundur Gudnason, Dan E Arking, Patricia B Munroe, Bruce M Psaty, Cornelia M van Duijn, Emelia J Benjamin, Jonathan Rosand, Nilesh J Samani, Torben Hansen, Stefan Kääb, Ozren Polasek, Pim van der Harst, Susan R Heckbert, J Wouter Jukema, Bruno H Stricker, Caroline Hayward, Marcus Dörr, Yalda Jamshidi, Folkert W Asselbergs, Charles Kooperberg, Terho Lehtimäki, James G Wilson, Patrick T Ellinor, Steven A Lubitz, Aaron Isaacs
BACKGROUND: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability. METHODS: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29743826/effect-of-bilberry-juice-on-indices-of-muscle-damage-and-inflammation-in-runners-completing-a-half-marathon-a-randomised-placebo-controlled-trial
#9
Anthony Lynn, Samantha Garner, Nichola Nelson, Trevor N Simper, Anna C Hall, Mayur K Ranchordas
Background: Emerging evidence indicates that fruits rich in polyphenols may attenuate exercise-induced muscle damage and associated markers of inflammation and soreness. This study was conducted to determine whether bilberry juice (BJ), which is particularly rich in polyphenols, reduces markers of muscle damage in runners completing a half marathon. Methods: A total of 21 recreationally trained runners (age 30.9 ± 10.4 y; mass 71.6 ± 11.0 kg; M = 16; F = 5) were recruited to a single blind, randomised, placebo-controlled, parallel study...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29742012/simultaneous-ipsilateral-transconjunctival-repair-of-upper-and-lower-eyelid-retraction-in-thyroid-associated-ophthalmopathy
#10
Nahyoung Grace Lee, Larissa Habib, Jonathan Hall, Suzanne K Freitag
PURPOSE: To report a simple, highly effective technique of simultaneous transconjunctival repair of upper and lower eyelid retraction in patients with thyroid eye disease (TED). METHODS: A retrospective interventional case review was conducted on 22 eyes of 19 TED patients. The lower eyelid was recessed with placement of a tarsoconjunctival spacer graft harvested from the upper eyelid. The upper eyelid was then recessed through the conjunctival incision used to harvest the tarsal graft...
May 9, 2018: Orbit
https://www.readbyqxmd.com/read/29741092/advancing-peptide-based-biorecognition-elements-for-biosensors-using-in-silico-evolution
#11
Xingqing Xiao, Zhifeng Kuang, Joseph M Slocik, Sirimuvva Tadepalli, Michael Brothers, Steve S Kim, Peter A Mirau, Claire Butkus, Barry L Farmer, Srikanth Singamaneni, Carol K Hall, Rajesh R Naik
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. BREs, including peptides, antibodies, and nucleic acids, bind to biomarkers in the vicinity of the sen-sor surface to create a signal proportional to the biomarker con-centration. The discovery of BREs with the required sensitivity and selectivity to bind biomarkers at low concentrations re-mains a fundamental challenge...
May 9, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29740044/magnetic-resonance-probing-of-ground-state-in-the-mixed-valence-correlated-topological-insulator-smb-6
#12
S V Demishev, M I Gilmanov, A N Samarin, A V Semeno, N E Sluchanko, N A Samarin, A V Bogach, N Yu Shitsevalova, V B Filipov, M S Karasev, V V Glushkov
Introducing of topological insulator concept for fluctuating valence compound - samarium hexaboride - has recently initiated a new round of studies aimed to clarify the nature of the ground state in this extraordinary system with strong electron correlations. Here we discuss the data of magnetic resonance in the pristine single crystals of SmB6 measured in 60 GHz cavity experiments at temperatures 1.8-300 K. The microwave study as well as the DC resistivity and Hall effect measurements performed for the different states of SmB6 [110] surface prove definitely the existence of the layer with metallic conductivity increasing under lowering temperature below 5 K...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735638/can-we-end-the-salt-wars-with-a-randomized-clinical-trial-in-a-controlled-environment
#13
EDITORIAL
Daniel W Jones, Friedrich C Luft, Paul K Whelton, Michael H Alderman, John E Hall, Eric D Peterson, Robert M Califf, David A McCarron
No abstract text is available yet for this article.
May 7, 2018: Hypertension
https://www.readbyqxmd.com/read/29731356/primary-care-and-home-visiting-utilization-patterns-among-at-risk-infants
#14
Neera K Goyal, Alonzo T Folger, Heidi J Sucharew, Courtney M Brown, Eric S Hall, Judith B Van Ginkel, Robert T Ammerman
OBJECTIVE: To describe well child care (WCC) utilization in the first year of life among at-risk infants, and the relationship to home visiting enrollment. STUDY DESIGN: Retrospective cohort study using linked administrative data for infants ≥34 weeks' gestation from 2010 to 2014, within a regional, academic primary care system. Association between WCC visits and home visiting enrollment was evaluated using bivariate comparisons and multivariable Poisson regression...
May 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29727810/ptsd-in-women-is-associated-with-a-block-in-conversion-of-progesterone-to-the-gabaergic-neurosteroids-allopregnanolone-and-pregnanolone-measured-in-plasma
#15
S L Pineles, Y I Nillni, G Pinna, J Irvine, A Webb, K A Arditte Hall, R Hauger, M W Miller, P A Resick, S P Orr, A M Rasmusson
There is a need to identify new and more effective treatments for posttraumatic stress disorder (PTSD). Allopregnanolone and its stereoisomer pregnanolone (together termed ALLO) are metabolites of progesterone that positively and allosterically modulate GABA effects at GABAA receptors, thereby reducing anxiety and depression. Previous research revealed that women with PTSD had low cerebrospinal fluid (CSF) ALLO levels and a low ratio of ALLO to the allopregnanolone precursor 5α-DHP, consistent with deficient activity of the ALLO synthetic enzyme 3α-hydroxysteroid dehydrogenase (3α-HSD)...
April 24, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29726254/phonon-mediated-colossal-magnetoresistance-in-graphene-black-phosphorous-heterostructures
#16
Yanpeng Liu, Indra Yudhistira, Ming Yang, Evan Laksono, Yong Zheng Luo, Jianyi Chen, Junpeng Lu, Yuan Ping Feng, Shaffique Adam, Kian Ping Loh
There is a huge demand for magnetoresistance (MR) sensors with high sensitivity, low energy consumption and room temperature operation. It is well known that spatial charge inhomogeneity due to impurities or defects introduce mobility fluctuations in monolayer graphene and give rise to magnetoresistance (MR) in the presence of an externally applied magnetic field. However, to realize a MR sensor based on this effect is hampered by the difficulty in controlling the spatial distribution of impurities and the weak magnetoresistance effect at the monolayer regime...
May 4, 2018: Nano Letters
https://www.readbyqxmd.com/read/29725242/prospects-for-observing-and-localizing-gravitational-wave-transients-with-advanced-ligo-advanced-virgo-and-kagra
#17
REVIEW
B P Abbott, R Abbott, T D Abbott, M R Abernathy, F Acernese, K Ackley, C Adams, T Adams, P Addesso, R X Adhikari, V B Adya, C Affeldt, M Agathos, K Agatsuma, N Aggarwal, O D Aguiar, L Aiello, A Ain, P Ajith, T Akutsu, B Allen, A Allocca, P A Altin, A Ananyeva, S B Anderson, W G Anderson, M Ando, S Appert, K Arai, A Araya, M C Araya, J S Areeda, N Arnaud, K G Arun, H Asada, S Ascenzi, G Ashton, Y Aso, M Ast, S M Aston, P Astone, S Atsuta, P Aufmuth, C Aulbert, A Avila-Alvarez, K Awai, S Babak, P Bacon, M K M Bader, L Baiotti, P T Baker, F Baldaccini, G Ballardin, S W Ballmer, J C Barayoga, S E Barclay, B C Barish, D Barker, F Barone, B Barr, L Barsotti, M Barsuglia, D Barta, J Bartlett, M A Barton, I Bartos, R Bassiri, A Basti, J C Batch, C Baune, V Bavigadda, M Bazzan, B Bécsy, C Beer, M Bejger, I Belahcene, M Belgin, A S Bell, B K Berger, G Bergmann, C P L Berry, D Bersanetti, A Bertolini, J Betzwieser, S Bhagwat, R Bhandare, I A Bilenko, G Billingsley, C R Billman, J Birch, R Birney, O Birnholtz, S Biscans, A Bisht, M Bitossi, C Biwer, M A Bizouard, J K Blackburn, J Blackman, C D Blair, D G Blair, R M Blair, S Bloemen, O Bock, M Boer, G Bogaert, A Bohe, F Bondu, R Bonnand, B A Boom, R Bork, V Boschi, S Bose, Y Bouffanais, A Bozzi, C Bradaschia, P R Brady, V B Braginsky, M Branchesi, J E Brau, T Briant, A Brillet, M Brinkmann, V Brisson, P Brockill, J E Broida, A F Brooks, D A Brown, D D Brown, N M Brown, S Brunett, C C Buchanan, A Buikema, T Bulik, H J Bulten, A Buonanno, D Buskulic, C Buy, R L Byer, M Cabero, L Cadonati, G Cagnoli, C Cahillane, J Calderón Bustillo, T A Callister, E Calloni, J B Camp, K C Cannon, H Cao, J Cao, C D Capano, E Capocasa, F Carbognani, S Caride, J Casanueva Diaz, C Casentini, S Caudill, M Cavaglià, F Cavalier, R Cavalieri, G Cella, C B Cepeda, L Cerboni Baiardi, G Cerretani, E Cesarini, S J Chamberlin, M Chan, S Chao, P Charlton, E Chassande-Mottin, B D Cheeseboro, H Y Chen, Y Chen, H-P Cheng, A Chincarini, A Chiummo, T Chmiel, H S Cho, M Cho, J H Chow, N Christensen, Q Chu, A J K Chua, S Chua, S Chung, G Ciani, F Clara, J A Clark, F Cleva, C Cocchieri, E Coccia, P-F Cohadon, A Colla, C G Collette, L Cominsky, M Constancio, L Conti, S J Cooper, T R Corbitt, N Cornish, A Corsi, S Cortese, C A Costa, M W Coughlin, S B Coughlin, J-P Coulon, S T Countryman, P Couvares, P B Covas, E E Cowan, D M Coward, M J Cowart, D C Coyne, R Coyne, J D E Creighton, T D Creighton, J Cripe, S G Crowder, T J Cullen, A Cumming, L Cunningham, E Cuoco, T Dal Canton, S L Danilishin, S D'Antonio, K Danzmann, A Dasgupta, C F Da Silva Costa, V Dattilo, I Dave, M Davier, G S Davies, D Davis, E J Daw, B Day, R Day, S De, D DeBra, G Debreczeni, J Degallaix, M De Laurentis, S Deléglise, W Del Pozzo, T Denker, T Dent, V Dergachev, R De Rosa, R T DeRosa, R DeSalvo, R C Devine, S Dhurandhar, M C Díaz, L Di Fiore, M Di Giovanni, T Di Girolamo, A Di Lieto, S Di Pace, I Di Palma, A Di Virgilio, Z Doctor, K Doi, V Dolique, F Donovan, K L Dooley, S Doravari, I Dorrington, R Douglas, M Dovale Álvarez, T P Downes, M Drago, R W P Drever, J C Driggers, Z Du, M Ducrot, S E Dwyer, K Eda, T B Edo, M C Edwards, A Effler, H-B Eggenstein, P Ehrens, J Eichholz, S S Eikenberry, R A Eisenstein, R C Essick, Z Etienne, T Etzel, M Evans, T M Evans, R Everett, M Factourovich, V Fafone, H Fair, S Fairhurst, X Fan, S Farinon, B Farr, W M Farr, E J Fauchon-Jones, M Favata, M Fays, H Fehrmann, M M Fejer, A Fernández Galiana, I Ferrante, E C Ferreira, F Ferrini, F Fidecaro, I Fiori, D Fiorucci, R P Fisher, R Flaminio, M Fletcher, H Fong, S S Forsyth, J-D Fournier, S Frasca, F Frasconi, Z Frei, A Freise, R Frey, V Frey, E M Fries, P Fritschel, V V Frolov, Y Fujii, M-K Fujimoto, P Fulda, M Fyffe, H Gabbard, B U Gadre, S M Gaebel, J R Gair, L Gammaitoni, S G Gaonkar, F Garufi, G Gaur, V Gayathri, N Gehrels, G Gemme, E Genin, A Gennai, J George, L Gergely, V Germain, S Ghonge, Abhirup Ghosh, Archisman Ghosh, S Ghosh, J A Giaime, K D Giardina, A Giazotto, K Gill, A Glaefke, E Goetz, R Goetz, L Gondan, G González, J M Gonzalez Castro, A Gopakumar, M L Gorodetsky, S E Gossan, M Gosselin, R Gouaty, A Grado, C Graef, M Granata, A Grant, S Gras, C Gray, G Greco, A C Green, P Groot, H Grote, S Grunewald, G M Guidi, X Guo, A Gupta, M K Gupta, K E Gushwa, E K Gustafson, R Gustafson, J J Hacker, A Hagiwara, B R Hall, E D Hall, G Hammond, M Haney, M M Hanke, J Hanks, C Hanna, M D Hannam, J Hanson, T Hardwick, J Harms, G M Harry, I W Harry, M J Hart, M T Hartman, C-J Haster, K Haughian, K Hayama, J Healy, A Heidmann, M C Heintze, H Heitmann, P Hello, G Hemming, M Hendry, I S Heng, J Hennig, J Henry, A W Heptonstall, M Heurs, S Hild, E Hirose, D Hoak, D Hofman, K Holt, D E Holz, P Hopkins, J Hough, E A Houston, E J Howell, Y M Hu, E A Huerta, D Huet, B Hughey, S Husa, S H Huttner, T Huynh-Dinh, N Indik, D R Ingram, R Inta, K Ioka, H N Isa, J-M Isac, M Isi, T Isogai, Y Itoh, B R Iyer, K Izumi, T Jacqmin, K Jani, P Jaranowski, S Jawahar, F Jiménez-Forteza, W W Johnson, D I Jones, R Jones, R J G Jonker, L Ju, J Junker, T Kagawa, T Kajita, M Kakizaki, C V Kalaghatgi, V Kalogera, M Kamiizumi, N Kanda, S Kandhasamy, S Kanemura, M Kaneyama, G Kang, J B Kanner, S Karki, K S Karvinen, M Kasprzack, Y Kataoka, E Katsavounidis, W Katzman, S Kaufer, T Kaur, K Kawabe, N Kawai, S Kawamura, F Kéfélian, D Keitel, D B Kelley, R Kennedy, J S Key, F Y Khalili, I Khan, S Khan, Z Khan, E A Khazanov, N Kijbunchoo, C Kim, H Kim, J C Kim, J Kim, W Kim, Y-M Kim, S J Kimbrell, N Kimura, E J King, P J King, R Kirchhoff, J S Kissel, B Klein, L Kleybolte, S Klimenko, P Koch, S M Koehlenbeck, Y Kojima, K Kokeyama, S Koley, K Komori, V Kondrashov, A Kontos, M Korobko, W Z Korth, K Kotake, I Kowalska, D B Kozak, C Krämer, V Kringel, B Krishnan, A Królak, G Kuehn, P Kumar, Rahul Kumar, Rakesh Kumar, L Kuo, K Kuroda, A Kutynia, Y Kuwahara, B D Lackey, M Landry, R N Lang, J Lange, B Lantz, R K Lanza, A Lartaux-Vollard, P D Lasky, M Laxen, A Lazzarini, C Lazzaro, P Leaci, S Leavey, E O Lebigot, C H Lee, H K Lee, H M Lee, H W Lee, K Lee, J Lehmann, A Lenon, M Leonardi, J R Leong, N Leroy, N Letendre, Y Levin, T G F Li, A Libson, T B Littenberg, J Liu, N A Lockerbie, A L Lombardi, L T London, J E Lord, M Lorenzini, V Loriette, M Lormand, G Losurdo, J D Lough, C O Lousto, G Lovelace, H Lück, A P Lundgren, R Lynch, Y Ma, S Macfoy, B Machenschalk, M MacInnis, D M Macleod, F Magaña-Sandoval, E Majorana, I Maksimovic, V Malvezzi, N Man, V Mandic, V Mangano, S Mano, G L Mansell, M Manske, M Mantovani, F Marchesoni, M Marchio, F Marion, S Márka, Z Márka, A S Markosyan, E Maros, F Martelli, L Martellini, I W Martin, D V Martynov, K Mason, A Masserot, T J Massinger, M Masso-Reid, S Mastrogiovanni, F Matichard, L Matone, N Matsumoto, F Matsushima, N Mavalvala, N Mazumder, R McCarthy, D E McClelland, S McCormick, C McGrath, S C McGuire, G McIntyre, J McIver, D J McManus, T McRae, S T McWilliams, D Meacher, G D Meadors, J Meidam, A Melatos, G Mendell, D Mendoza-Gandara, R A Mercer, E L Merilh, M Merzougui, S Meshkov, C Messenger, C Messick, R Metzdorff, P M Meyers, F Mezzani, H Miao, C Michel, Y Michimura, H Middleton, E E Mikhailov, L Milano, A L Miller, A Miller, B B Miller, J Miller, M Millhouse, Y Minenkov, J Ming, S Mirshekari, C Mishra, V P Mitrofanov, G Mitselmakher, R Mittleman, O Miyakawa, A Miyamoto, T Miyamoto, S Miyoki, A Moggi, M Mohan, S R P Mohapatra, M Montani, B C Moore, C J Moore, D Moraru, G Moreno, W Morii, S Morisaki, Y Moriwaki, S R Morriss, B Mours, C M Mow-Lowry, G Mueller, A W Muir, Arunava Mukherjee, D Mukherjee, S Mukherjee, N Mukund, A Mullavey, J Munch, E A M Muniz, P G Murray, A Mytidis, S Nagano, K Nakamura, T Nakamura, H Nakano, Masaya Nakano, Masayuki Nakano, K Nakao, K Napier, I Nardecchia, T Narikawa, L Naticchioni, G Nelemans, T J N Nelson, M Neri, M Nery, A Neunzert, J M Newport, G Newton, T T Nguyen, W-T Ni, A B Nielsen, S Nissanke, A Nitz, A Noack, F Nocera, D Nolting, M E N Normandin, L K Nuttall, J Oberling, E Ochsner, E Oelker, G H Ogin, J J Oh, S H Oh, M Ohashi, N Ohishi, M Ohkawa, F Ohme, K Okutomi, M Oliver, K Ono, Y Ono, K Oohara, P Oppermann, Richard J Oram, B O'Reilly, R O'Shaughnessy, D J Ottaway, H Overmier, B J Owen, A E Pace, J Page, A Pai, S A Pai, J R Palamos, O Palashov, C Palomba, A Pal-Singh, H Pan, C Pankow, F Pannarale, B C Pant, F Paoletti, A Paoli, M A Papa, H R Paris, W Parker, D Pascucci, A Pasqualetti, R Passaquieti, D Passuello, B Patricelli, B L Pearlstone, M Pedraza, R Pedurand, L Pekowsky, A Pele, F E Peña Arellano, S Penn, C J Perez, A Perreca, L M Perri, H P Pfeiffer, M Phelps, O J Piccinni, M Pichot, F Piergiovanni, V Pierro, G Pillant, L Pinard, I M Pinto, M Pitkin, M Poe, R Poggiani, P Popolizio, A Post, J Powell, J Prasad, J W W Pratt, V Predoi, T Prestegard, M Prijatelj, M Principe, S Privitera, G A Prodi, L G Prokhorov, O Puncken, M Punturo, P Puppo, M Pürrer, H Qi, J Qin, S Qiu, V Quetschke, E A Quintero, R Quitzow-James, F J Raab, D S Rabeling, H Radkins, P Raffai, S Raja, C Rajan, M Rakhmanov, P Rapagnani, V Raymond, M Razzano, V Re, J Read, T Regimbau, L Rei, S Reid, D H Reitze, H Rew, S D Reyes, E Rhoades, F Ricci, K Riles, M Rizzo, N A Robertson, R Robie, F Robinet, A Rocchi, L Rolland, J G Rollins, V J Roma, R Romano, J H Romie, D Rosińska, S Rowan, A Rüdiger, P Ruggi, K Ryan, S Sachdev, T Sadecki, L Sadeghian, N Sago, M Saijo, Y Saito, K Sakai, M Sakellariadou, L Salconi, M Saleem, F Salemi, A Samajdar, L Sammut, L M Sampson, E J Sanchez, V Sandberg, J R Sanders, Y Sasaki, B Sassolas, B S Sathyaprakash, S Sato, T Sato, P R Saulson, O Sauter, R L Savage, A Sawadsky, P Schale, J Scheuer, E Schmidt, J Schmidt, P Schmidt, R Schnabel, R M S Schofield, A Schönbeck, E Schreiber, D Schuette, B F Schutz, S G Schwalbe, J Scott, S M Scott, T Sekiguchi, Y Sekiguchi, D Sellers, A S Sengupta, D Sentenac, V Sequino, A Sergeev, Y Setyawati, D A Shaddock, T J Shaffer, M S Shahriar, B Shapiro, P Shawhan, A Sheperd, M Shibata, Y Shikano, T Shimoda, A Shoda, D H Shoemaker, D M Shoemaker, K Siellez, X Siemens, M Sieniawska, D Sigg, A D Silva, A Singer, L P Singer, A Singh, R Singh, A Singhal, A M Sintes, B J J Slagmolen, B Smith, J R Smith, R J E Smith, K Somiya, E J Son, B Sorazu, F Sorrentino, T Souradeep, A P Spencer, A K Srivastava, A Staley, M Steinke, J Steinlechner, S Steinlechner, D Steinmeyer, B C Stephens, S P Stevenson, R Stone, K A Strain, N Straniero, G Stratta, S E Strigin, R Sturani, A L Stuver, Y Sugimoto, T Z Summerscales, L Sun, S Sunil, P J Sutton, T Suzuki, B L Swinkels, M J Szczepańczyk, M Tacca, H Tagoshi, S Takada, H Takahashi, R Takahashi, A Takamori, D Talukder, H Tanaka, K Tanaka, T Tanaka, D B Tanner, M Tápai, A Taracchini, D Tatsumi, R Taylor, S Telada, T Theeg, E G Thomas, M Thomas, P Thomas, K A Thorne, E Thrane, T Tippens, S Tiwari, V Tiwari, K V Tokmakov, K Toland, T Tomaru, C Tomlinson, M Tonelli, Z Tornasi, C I Torrie, D Töyrä, F Travasso, G Traylor, D Trifirò, J Trinastic, M C Tringali, L Trozzo, M Tse, R Tso, K Tsubono, T Tsuzuki, M Turconi, D Tuyenbayev, T Uchiyama, T Uehara, S Ueki, K Ueno, D Ugolini, C S Unnikrishnan, A L Urban, T Ushiba, S A Usman, H Vahlbruch, G Vajente, G Valdes, N van Bakel, M van Beuzekom, J F J van den Brand, C Van Den Broeck, D C Vander-Hyde, L van der Schaaf, J V van Heijningen, M H P M van Putten, A A van Veggel, M Vardaro, V Varma, S Vass, M Vasúth, A Vecchio, G Vedovato, J Veitch, P J Veitch, K Venkateswara, G Venugopalan, D Verkindt, F Vetrano, A Viceré, A D Viets, S Vinciguerra, D J Vine, J-Y Vinet, S Vitale, T Vo, H Vocca, C Vorvick, D V Voss, W D Vousden, S P Vyatchanin, A R Wade, L E Wade, M Wade, T Wakamatsu, M Walker, L Wallace, S Walsh, G Wang, H Wang, M Wang, Y Wang, R L Ward, J Warner, M Was, J Watchi, B Weaver, L-W Wei, M Weinert, A J Weinstein, R Weiss, L Wen, P Weßels, T Westphal, K Wette, J T Whelan, B F Whiting, C Whittle, D Williams, R D Williams, A R Williamson, J L Willis, B Willke, M H Wimmer, W Winkler, C C Wipf, H Wittel, G Woan, J Woehler, J Worden, J L Wright, D S Wu, G Wu, W Yam, H Yamamoto, K Yamamoto, T Yamamoto, C C Yancey, K Yano, M J Yap, J Yokoyama, T Yokozawa, T H Yoon, Hang Yu, Haocun Yu, H Yuzurihara, M Yvert, A Zadrożny, L Zangrando, M Zanolin, S Zeidler, J-P Zendri, M Zevin, L Zhang, M Zhang, T Zhang, Y Zhang, C Zhao, M Zhou, Z Zhou, S J Zhu, X J Zhu, M E Zucker, J Zweizig
We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals, and study the capability of the network to determine the sky location of the source. We report our findings for gravitational-wave transients, with particular focus on gravitational-wave signals from the inspiral of binary neutron star systems, which are the most promising targets for multi-messenger astronomy...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29725138/p-type-doping-efficiency-in-cdte-influence-of-second-phase-formation
#18
Jedidiah J McCoy, Santosh K Swain, John R Sieber, David R Diercks, Brian P Gorman, Kelvin G Lynn
Cadmium telluride (CdTe) high purity, bulk, crystal ingots doped with phosphorus were grown by the vertical Bridgman melt growth technique to understand and improve dopant solubility and activation. Large net carrier densities have been reproducibly obtained from as-grown ingots, indicating successful incorporation of dopants into the lattice. However, net carrier density values are orders of magnitude lower than the solubility of P in CdTe as reported in literature, 1018 /cm3 to 1019 /cm3 [J. H. Greenberg, J...
April 2018: Journal of Applied Physics
https://www.readbyqxmd.com/read/29724098/simulations-and-experiments-delineate-amyloid-fibrilization-by-peptides-derived-from-glaucoma-associated-myocilin
#19
Yiming Wang, Yuan Gao, Shannon E Hill, Dustin J E Huard, Moya O Tomlin, Raquel L Lieberman, Anant K Paravastu, Carol K Hall
Mutant myocilin aggregation is associated with inherited open angle glaucoma, a prevalent optic neuropathy leading to blindness. Comprehension of mutant myocilin aggregation is of fundamental importance to glaucoma pathogenesis and ties glaucoma to amyloid diseases such as Alzheimer's. Here we probe the aggregation properties of peptides derived from the myocilin olfactomedin domain. Peptides P1 (residues 326-337) and P3 (residues 426-442) were identified previously to form amyloid. Coarse-grained discontinuous molecular dynamics simulations using the PRIME20 force field (DMD/PRIME20) predict that P1 and P3 are aggregation-prone; P1 consistently forms fibrillar aggregates with parallel in-register β-sheets whereas P3 forms β-sheet-containing aggregates without distinct order...
May 3, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29723800/familial-alcohol-supply-adolescent-drinking-and-early-alcohol-onset-in-45-low-and-middle-income-countries
#20
Gary C K Chan, Janni Leung, Adrian B Kelly, Jason Connor, Stephanie Edward, Wayne Hall, Louisa Degenhardt, Vivian Chiu, George Patton
AIMS: This study estimated the extent of familial alcohol supply in 45 low and middle income countries (LMIC), and examined the country-level effects of familial alcohol supply on adolescents' alcohol use. METHOD: We used data from 45 LMICs that participated in the Global School-Based Student Health Survey (GSHS) between 2003 and 2013 (n = 139,840). The weighted prevalence of familial alcohol supply in each country was estimated. Multilevel binary and ordinal logistic regression analyses were used to examine the country-level effect of familial alcohol supply on early onset of alcohol use (first alcohol before 12), past 30-day alcohol use, lifetime drunkenness and alcohol-related social problems...
April 24, 2018: Addictive Behaviors
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