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https://www.readbyqxmd.com/read/28356275/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-of-the-effect-of-konjac-glucomannan-a-viscous-soluble-fiber-on-ldl-cholesterol-and-the-new-lipid-targets-non-hdl-cholesterol-and-apolipoprotein-b
#1
Hoang Vi Thanh Ho, Elena Jovanovski, Andreea Zurbau, Sonia Blanco Mejia, John L Sievenpiper, Fei Au-Yeung, Alexandra L Jenkins, Lea Duvnjak, Lawrence Leiter, Vladimir Vuksan
Background: Evidence from randomized controlled trials (RCTs) suggests the consumption of konjac glucomannan (KJM), a viscous soluble fiber, for improving LDL-cholesterol concentrations. It has also been suggested that the cholesterol-lowering potential of KJM may be greater than that of other fibers. However, trials have been relatively scarce and limited in sample size and duration, and the effect estimates have been inconsistent. The effect of KJM on new lipid targets of cardiovascular disease (CVD) risk is also unknown...
March 29, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28347513/cost-effectiveness-of-maintaining-daily-intake-of-oat-%C3%AE-glucan-for-coronary-heart-disease-primary-prevention
#2
Stephanie R Earnshaw, Cheryl L McDade, YiFang Chu, Lisa E Fleige, John L Sievenpiper
PURPOSE: Oat β-glucan reduces cholesterol levels and thus reduces the risk for coronary heart disease (CHD). However, its economic impact has not been well studied. We examined the economic impact of daily intake of ≥3 g of oat β-glucan in primary prevention of CHD in patients receiving statins or no pharmacologic treatment. METHODS: A decision model was developed to compare costs and outcomes associated with lowering cholesterol levels with no pharmacologic treatment and normal diet, no pharmacologic treatment plus ≥3 g/d of oat β-glucan, and statin therapy plus ≥3 g/d of oat β-glucan...
March 25, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28336747/cross-sectional-associations-between-dietary-intake-and-carotid-intima-media-thickness-in-type-2-diabetes-baseline-data-from-a-randomised-trial
#3
Laura Chiavaroli, Arash Mirrahimi, Christopher Ireland, Sandra Mitchell, Sandhya Sahye-Pudaruth, Judy Coveney, Omodele Olowoyeye, Darshna Patel, Russell J de Souza, Livia S A Augustin, Balachandran Bashyam, Sathish Chandra Pichika, Sonia Blanco Mejia, Stephanie K Nishi, Lawrence A Leiter, Robert G Josse, Gail E McKeown-Eyssen, Alan R Moody, Cyril W C Kendall, John L Sievenpiper, David J A Jenkins
OBJECTIVE: To assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes. DESIGN: Cross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way. SETTING: Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada. PARTICIPANTS: 325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28253436/can-pulses-play-a-role-in-improving-cardiometabolic-health-evidence-from-systematic-reviews-and-meta-analyses
#4
Effie Viguiliouk, Sonia Blanco Mejia, Cyril W C Kendall, John L Sievenpiper
Obesity, diabetes, and cardiovascular disease (CVD) present important unmet prevention and treatment challenges. Dietary pulses are sustainable, affordable, and nutrient-dense foods that have shown a wide range of health benefits in the prevention and management of these conditions. Despite these findings, recommendations for pulse intake continue to vary across chronic disease guidelines, and intake levels continue to remain low. Here, we summarize findings from recent systematic reviews and meta-analyses assessing the relationship between dietary pulse consumption and cardiometabolic health and assess the overall strength of the evidence using the Grading of Recommendations, Assessment, Development, and Evaluation tool...
March 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28089080/salba-chia-salvia-hispanica-l-in-the-treatment-of-overweight-and-obese-patients-with-type-2-diabetes-a-double-blind-randomized-controlled-trial
#5
V Vuksan, A L Jenkins, C Brissette, L Choleva, E Jovanovski, A L Gibbs, R P Bazinet, F Au-Yeung, A Zurbau, H V T Ho, L Duvnjak, J L Sievenpiper, R G Josse, A Hanna
BACKGROUND AND AIM: Preliminary findings indicate that consumption of Salba-chia (Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. The aim of this study was to assesse the effect of Salba-chia on body weight, visceral obesity and obesity-related risk factors in overweight and obese adults with type 2 diabetes. METHODS: A double-blind, randomized, controlled trial with two parallel groups involved 77 overweight or obese patients with type 2 diabetes (HbA1c: 6...
February 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27974597/what-is-the-appropriate-upper-limit-for-added-sugars-consumption
#6
James M Rippe, John L Sievenpiper, Kim-Anne Lê, John S White, Roger Clemens, Theodore J Angelopoulos
Dramatic increases in obesity and diabetes have occurred worldwide over the past 30 years. Some investigators have suggested that these increases may be due, in part, to increased added sugars consumption. Several scientific organizations, including the World Health Organization, the Scientific Advisory Council on Nutrition, the Dietary Guidelines Advisory Committee 2015, and the American Heart Association, have recommended significant restrictions on upper limits of sugars consumption. In this review, the scientific evidence related to sugars consumption and its putative link to various chronic conditions such as obesity, diabetes, heart disease, nonalcoholic fatty liver disease, and the metabolic syndrome is examined...
January 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/27912869/erratum-to-sickeningly-sweet-does-sugar-cause-chronic-disease-no-canadian-journal-of-diabetes-volume-40-2016-pages-287-295
#7
John L Sievenpiper
No abstract text is available yet for this article.
December 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27900447/controversies-about-sugars-results-from-systematic-reviews-and-meta-analyses-on-obesity-cardiometabolic-disease-and-diabetes
#8
REVIEW
Tauseef A Khan, John L Sievenpiper
Fructose-containing sugars are a focus of attention as a public health target for their putative role in obesity and cardiometabolic disease including diabetes. The fructose moiety is singled out to be the primary driver for the harms of sugars due to its unique endocrine signal and pathophysiological role. However, this is only supported by ecological studies, animal models of overfeeding and select human intervention studies with supraphysiological doses or lack of control for energy. The highest level of evidence from systematic reviews and meta-analyses of controlled trials has not shown that fructose-containing sugars behave any differently from other forms of digestible carbohydrates...
November 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27811946/photoemission-based-microelectronic-devices
#9
Ebrahim Forati, Tyler J Dill, Andrea R Tao, Dan Sievenpiper
The vast majority of modern microelectronic devices rely on carriers within semiconductors due to their integrability. Therefore, the performance of these devices is limited due to natural semiconductor properties such as band gap and electron velocity. Replacing the semiconductor channel in conventional microelectronic devices with a gas or vacuum channel may scale their speed, wavelength and power beyond what is available today. However, liberating electrons into gas/vacuum in a practical microelectronic device is quite challenging...
November 4, 2016: Nature Communications
https://www.readbyqxmd.com/read/27805621/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-of-the-effect-of-barley-%C3%AE-glucan-on-ldl-c-non-hdl-c-and-apob-for-cardiovascular-disease-risk-reduction-i-iv
#10
H V T Ho, J L Sievenpiper, A Zurbau, S Blanco Mejia, E Jovanovski, F Au-Yeung, A L Jenkins, V Vuksan
No abstract text is available yet for this article.
November 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27724985/the-effect-of-oat-%C3%AE-glucan-on-ldl-cholesterol-non-hdl-cholesterol-and-apob-for-cvd-risk-reduction-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#11
REVIEW
Hoang V T Ho, John L Sievenpiper, Andreea Zurbau, Sonia Blanco Mejia, Elena Jovanovski, Fei Au-Yeung, Alexandra L Jenkins, Vladimir Vuksan
Oats are a rich source of β-glucan, a viscous, soluble fibre recognised for its cholesterol-lowering properties, and are associated with reduced risk of CVD. Our objective was to conduct a systematic review and meta-analysis of randomised-controlled trials (RCT) investigating the cholesterol-lowering potential of oat β-glucan on LDL-cholesterol, non-HDL-cholesterol and apoB for the risk reduction of CVD. MEDLINE, Embase, CINAHL and Cochrane CENTRAL were searched. We included RCT of ≥3 weeks of follow-up, assessing the effect of diets enriched with oat β-glucan compared with controlled diets on LDL-cholesterol, non-HDL-cholesterol or apoB...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27712954/2016-canadian-cardiovascular-society-guidelines-for-the-management-of-dyslipidemia-for-the-prevention-of-cardiovascular-disease-in-the-adult
#12
Todd J Anderson, Jean Grégoire, Glen J Pearson, Arden R Barry, Patrick Couture, Martin Dawes, Gordon A Francis, Jacques Genest, Steven Grover, Milan Gupta, Robert A Hegele, David C Lau, Lawrence A Leiter, Eva Lonn, G B John Mancini, Ruth McPherson, Daniel Ngui, Paul Poirier, John L Sievenpiper, James A Stone, George Thanassoulis, Richard Ward
Since the publication of the 2012 guidelines new literature has emerged to inform decision-making. The 2016 guidelines primary panel selected a number of clinically relevant questions and has produced updated recommendations, on the basis of important new findings. In subjects with clinical atherosclerosis, abdominal aortic aneurysm, most subjects with diabetes or chronic kidney disease, and those with low-density lipoprotein cholesterol ≥ 5 mmol/L, statin therapy is recommended. For all others, there is an emphasis on risk assessment linked to lipid determination to optimize decision-making...
November 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27697882/fructose-intake-and-risk-of-gout-and-hyperuricemia-a-systematic-review-and-meta-analysis-of-prospective-cohort-studies
#13
Joseph Jamnik, Sara Rehman, Sonia Blanco Mejia, Russell J de Souza, Tauseef A Khan, Lawrence A Leiter, Thomas M S Wolever, Cyril W C Kendall, David J A Jenkins, John L Sievenpiper
BACKGROUND: The prevalence of hyperuricemia and gout has increased in recent decades. The role of dietary fructose in the development of these conditions remains unclear. OBJECTIVE: To conduct a systematic review and meta-analysis of prospective cohort studies investigating the association fructose consumption with incident gout and hyperuricemia. DESIGN: MEDLINE, EMBASE and the Cochrane Library were searched (through September 2015). We included prospective cohort studies that assessed fructose consumption and incident gout or hyperuricemia...
October 3, 2016: BMJ Open
https://www.readbyqxmd.com/read/27516346/responses-of-waveform-selective-absorbing-metasurfaces-to-oblique-waves-at-the-same-frequency
#14
Hiroki Wakatsuchi, Fei Gao, Satoshi Yagitani, Daniel F Sievenpiper
Conventional materials vary their electromagnetic properties in response to the frequency of an incoming wave, but these responses generally remain unchanged at the same frequency unless nonlinearity is involved. Waveform-selective metasurfaces, recently developed by integrating several circuit elements with planar subwavelength periodic structures, allowed us to distinguish different waves even at the same frequency depending on how long the waves continued, namely, on their pulse widths. These materials were thus expected to give us an additional degree of freedom to control electromagnetic waves...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27497149/sickeningly-sweet-does-sugar-cause-chronic-disease-no
#15
John L Sievenpiper
No abstract text is available yet for this article.
August 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27388364/low-glycaemic-index-diet-to-improve-glycaemic-control-and-cardiovascular-disease-in-type-2-diabetes-design-and-methods-for-a-randomised-controlled-clinical-trial
#16
Laura Chiavaroli, Arash Mirrahimi, Christopher Ireland, Sandra Mitchell, Sandhya Sahye-Pudaruth, Judy Coveney, Omodele Olowoyeye, Tishan Maraj, Darshna Patel, Russell J de Souza, Livia S A Augustin, Balachandran Bashyam, Sonia Blanco Mejia, Stephanie K Nishi, Lawrence A Leiter, Robert G Josse, Gail McKeown-Eyssen, Alan R Moody, Alan R Berger, Cyril W C Kendall, John L Sievenpiper, David J A Jenkins
INTRODUCTION: Type 2 diabetes (T2DM) produces macrovascular and microvascular damage, significantly increasing the risk of cardiovascular disease (CVD), renal failure and blindness. As rates of T2DM rise, the need for effective dietary and other lifestyle changes to improve diabetes management become more urgent. Low-glycaemic index (GI) diets may improve glycaemic control in diabetes in the short term; however, there is a lack of evidence on the long-term adherence to low-GI diets, as well as on the association with surrogate markers of CVD beyond traditional risk factors...
July 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27273067/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-of-the-effect-of-barley-%C3%AE-glucan-on-ldl-c-non-hdl-c-and-apob-for-cardiovascular-disease-risk-reduction-i-iv
#17
H V T Ho, J L Sievenpiper, A Zurbau, S Blanco Mejia, E Jovanovski, F Au-Yeung, A L Jenkins, V Vuksan
BACKGROUND/OBJECTIVES: There has been recent interest in barley as a therapeutic food owing to its high content of beta-glucan (β-glucan), a viscous soluble fiber recognized for its cholesterol-lowering properties. The objective of this study was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the cholesterol-lowering potential of barley β-glucan on low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein B (apoB) for cardiovascular disease (CVD) risk reduction...
November 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27074879/the-effect-of-ginseng-genus-panax-on-blood-pressure-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#18
A M Komishon, E Shishtar, V Ha, J L Sievenpiper, R J de Souza, E Jovanovski, H V T Ho, L S Duvnjak, V Vuksan
Pre-clinical evidence indicates the potential for ginseng to reduce cardiovascular disease risk and acutely aid in blood pressure (BP) control. Clinical evidence evaluating repeated ginseng exposure, however, is controversial, triggering consumer and clinician concern. A systematic review and meta-analysis were conducted to assess whether ginseng has an effect on BP. MEDLINE, EMBASE, Cochrane and CINAHL were searched for relevant randomized controlled trials ⩾4 weeks that compared the effect of ginseng on systolic (SBP), diastolic (DBP) and/or mean arterial (MAP) BPs to control...
October 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27030531/effects-of-dietary-pulse-consumption-on-body-weight-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#19
Shana J Kim, Russell J de Souza, Vivian L Choo, Vanessa Ha, Adrian I Cozma, Laura Chiavaroli, Arash Mirrahimi, Sonia Blanco Mejia, Marco Di Buono, Adam M Bernstein, Lawrence A Leiter, Penny M Kris-Etherton, Vladimir Vuksan, Joseph Beyene, Cyril Wc Kendall, David Ja Jenkins, John L Sievenpiper
BACKGROUND: Obesity is a risk factor for developing several diseases, and although dietary pulses (nonoil seeds of legumes such as beans, lentils, chickpeas, and dry peas) are well positioned to aid in weight control, the effects of dietary pulses on weight loss are unclear. OBJECTIVE: We summarized and quantified the effects of dietary pulse consumption on body weight, waist circumference, and body fat by conducting a systematic review and meta-analysis of randomized controlled trials...
May 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26832529/experimental-study-of-the-interaction-between-dc-discharge-microplasmas-and-cw-lasers
#20
Ebrahim Forati, Shiva Piltan, Aobo Li, Dan Sievenpiper
A high power (~ 1W) continuous wave (CW) laser was focused on argon microplasma generated in the microgap between two electrodes with submillimeter diameters. Dependence of breakdown (V(BD)) and quench (V(Q)) voltages of microplasma to the laser power, wavelength, and spot location were studied as the gap size and pressure varied. It was observed that the laser-plasma interaction can only occur thermally through the electrodes. Also, the thermal effect of the laser was noticeable at relatively higher pressures (> 10Torr), and in most cases led to a decrease in V(BD), proportional to the pressure...
January 25, 2016: Optics Express
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