keyword
https://read.qxmd.com/read/38476731/hepatic-alveolar-echinococcosis-simulating-metastatic-malignancy
#21
Suvradeep Mitra, Payal Charaya, Shrinath Gururaj Deshpande, Mayur Parkhi, Thakur Deen Yadav
Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus Echinococcus . Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis. The common form is a zoonosis from goats and sheep that tends to cause liver lesions. The larval stage of Echinococcus multilocularis causes alveolar echinococcosis/alveolar hydatid disease. It is a zoonosis with field mice and tundra voles as intermediate and wild carnivores like foxes and wolves as definitive hosts...
2024: Autopsy & Case Reports
https://read.qxmd.com/read/38475885/heartworm-disease-in-domestic-dogs-in-estonia-indication-of-local-circulation-of-the-zoonotic-parasite-dirofilaria-immitis-farther-north-than-previously-reported
#22
JOURNAL ARTICLE
Maare Mõttus, Paul F Mõtsküla, Pikka Jokelainen
BACKGROUND: The mosquito-borne zoonotic parasite Dirofilaria immitis continues to spread northwards in Europe. This parasite can cause potentially life-threatening heartworm disease in dogs and pulmonary dirofilariasis in humans and is, therefore, a major health concern in both the veterinary medicine and human medical fields. This is the first report of D. immitis infections and heartworm disease in the Baltic country Estonia. METHODS: Data on canine D. immitis infections and heartworm disease were collected from the electronic patient records database of the Small Animal Clinic of Estonian University of Life Sciences, the only university clinic in Estonia...
March 12, 2024: Parasites & Vectors
https://read.qxmd.com/read/38473798/-ehrlichia-chaffeensis-etf-3-induces-host-rab15-upregulation-for-bacterial-intracellular-growth
#23
JOURNAL ARTICLE
Nan Yang, Meifang Li, Shanhua Qin, Nan Duan, Xiaoxiao Li, Yuhong Zhou, Mengyao Wang, Yongxin Jin, Weihui Wu, Zhihui Cheng
Ehrlichia chaffeensis infects human monocytes or macrophages and causes human monocytic ehrlichiosis (HME), an emerging life-threatening zoonosis. After internalization, E. chaffeensis resides in membrane-bound inclusions, E. chaffeensis -containing vesicles (ECVs), which have early endosome-like characteristics and fuse with early autophagosomes but not lysosomes, to evade host innate immune microbicidal mechanisms and obtain nutrients for bacterial intracellular growth. The mechanisms exploited by E. chaffeensis to modulate intracellular vesicle trafficking in host cells have not been comprehensively studied...
February 22, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38468116/molecular-detection-of-bacterial-zoonotic-abortive-agents-from-ruminants-in-turkey
#24
JOURNAL ARTICLE
Derya Karataş Yeni, Aslı Balevi, Asma Ashraf, MSalahuddin Shah, Fatih Büyük
Abortions in cattle and sheep are one of the major causes of economic losses worldwide. Brucella spp. are the most common infectious agent associated with these abortions. However, abortions caused by bacteria such as Listeria spp., Leptospira spp., Campylobacter spp. and Mycoplasma spp. are usually overlooked due to their sporadic nature and their status as non-priority abortion agents. In our study, we investigated the bacteria associated with abortion cases in cattle and sheep using PCR. For this purpose, we collected vaginal swab samples (n: 110) of aborted cattle and sheep, as well as stomach content samples (n: 69) of aborted calves and lambs from various cities in Turkey...
March 12, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://read.qxmd.com/read/38466771/efficacy-and-safety-of-therapeutic-strategies-for-human-brucellosis-a-systematic-review-and-network-meta-analysis
#25
JOURNAL ARTICLE
Sarah Nascimento Silva, Gláucia Cota, Diego Mendes Xavier, Glaciele Maria de Souza, Marina Rocha Fonseca Souza, Moisés Willian Aparecido Gonçalves, Felipe Francisco Bondan Tuon, Endi Lanza Galvão
BACKGROUND: Human brucellosis is a neglected, re-emerging, and endemic zoonosis in many countries. The debilitating and disabling potential of the disease is a warning about its morbidity, generating socioeconomic impact. This review aims to update the current evidence on the efficacy and safety of therapeutic options for human brucellosis using the network meta-analysis (NMA). METHODOLOGY: A systematic search was conducted in four different databases by independent reviewers to assess overall therapy failure, adverse events, and time to defervescence associated with different therapies...
March 11, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38466372/occupational-exposure-to-coxiella-burnetii-during-cardiac-surgery-a-case-report-and-review-of-the-literature
#26
JOURNAL ARTICLE
Patient Diwunga, Matthieu Million, Isabelle Ravaux, Pierre Edouard Fournier, Philippe Gautret
We report a case of exposure to Coxiella burnetii in a surgical nurse who underwent an injury of her finger with a scalpel blade during a native aortic valve replacement with a bio-prosthetic cardiac valve conducted on a patient suffering from C. burnetii aortic endocarditis. Given the positivity of C. burnetii culture and PCR from the patient's aortic valve, she was prescribed prophylactic doxycycline 100 mg twice a day for 10 days. Q fever is an occupational zoonosis resulting usually of exposure to infected animals by inhalation of infected aerosols or consumption of contaminated raw milk...
March 11, 2024: Acta Microbiologica et Immunologica Hungarica
https://read.qxmd.com/read/38463928/severe-murine-typhus-complicated-by-multiple-organ-dysfunctions-a-case-report
#27
Ermira Muco, Arta Karruli, Anjeza Dajlani, Arjana Zerja, Artan Bego
BACKGROUND: Rickettsioses are infectious diseases which are caused by intracellular bacteria which belong to the family Rickettsiaceae. This zoonosis endemically prefers tropical and subtropical regions of which the Mediterranean is included. Murine typhus is a type of rickettsial disease that commonly presents with undulating fever, headache rash, chills, malaise, and myalgias. It can lead to complications such as multi-organ failure and has a lethality rate of <5% in such cases. CASE PRESENTATION: A 70-year-old male was hospitalized at the Unit of Infectious Diseases, Mother Teresa Hospital, Tirana, Albania in a comatose condition...
2024: Caspian Journal of Internal Medicine
https://read.qxmd.com/read/38462304/trypanosoma-cruzi-antibody-screening-in-north-texas-client-owned-dogs
#28
JOURNAL ARTICLE
Wendy Pace, Joseph Oppong
Despite multiple screening efforts to identify exposures to Trypanosoma cruzi, in dogs across southern USA, no published studies could be found involving client owned dogs in the North Texas Metroplex area. Therefore, a limited screen was conducted for client owned dogs, seeking routine or preventative care, from participating veterinary practices in the greater Dallas-Fort Worth (DFW) Metroplex from 2019 to 2021. Participants, with owner consent, ranged in age, breed, and length of time at recorded residence...
April 2024: Veterinary Parasitology (Amsterdam)
https://read.qxmd.com/read/38459199/-new-awareness-for-zoonoses-using-the-example-of-rat-bite-fever-case-report-and-literature-review
#29
REVIEW
M Marschner, C Hausdorf, M Lüno, K Schlatterer
BACKGROUND: Rat bite fever is a rare but potentially fatal bacterial zoonosis. The symptoms can be unspecific, but severe sepsis can be associated with involvement of different organs. CASE REPORT: A 27-year-old homeless man presented with fever, suspected meningitis, acute renal failure, unclear skin lesions as well as joint problems and muscular pain. Bite wounds were not detected. Meningitis could be excluded after lumbar puncture, and there was no evidence of endocarditis as the cause of the skin lesions...
March 8, 2024: Inn Med (Heidelb)
https://read.qxmd.com/read/38458407/community-based-symptom-reporting-among-agro-pastoralists-and-their-livestock-in-chad-in-a-one-health-approach
#30
JOURNAL ARTICLE
Camille Doras, Ranya Özcelik, Mahamat Fayiz Abakar, Ramadan Issa, Pidou Kimala, Soumaya Youssouf, Isabelle Bolon, Salome Dürr
One Health Syndromic Surveillance has a high potential for detecting early epidemiological events in remote and hard-to-reach populations. Chadian pastoralists living close to their animals and being socio-economically unprivileged have an increased risk for zoonosis exposure. Engaging communities in disease surveillance could also strengthen preparedness capacities for outbreaks in rural Chad. This study describes a retrospective cross-sectional survey that collected data on clinical symptoms reported in people and livestock in Chadian agro-pastoral communities...
March 6, 2024: Acta Tropica
https://read.qxmd.com/read/38456027/presumptive-pulmonary-toxocariasis-in-a-patient-affected-by-acute-myeloid-leukemia-and-hodgkin-lymphoma-case-report-and-review-of-the-literature-in-immunocompromised-hosts
#31
Tommaso Lupia, Elena Crisà, Valentina Sangiorgio, Roberta Bosio, Giacomo Stroffolini, Elena Staffilano, Vanesa Gregorc, Silvia Corcione, Francesco Giuseppe De Rosa
Toxocariasis is a zoonosis transmitted by the nematode Toxocara spp. Immunocompromised hosts are more susceptible than general population to bacterial, viral, fungal and parasitic infections. In this population toxocariasis may present as exacerbation or reactivation and could have severe or atypical manifestations being a diagnostic challenge for healthcare providers. We report a case of a presumptive pulmonary toxocariasis during chemotherapy in a patient affected by acute myeloid leukaemia (AML) and Hodgkin lymphoma and we summarize current evidence of pulmonary involvement in immunocompromised population with Toxocara spp infection in a narrative review...
2024: Le Infezioni in Medicina
https://read.qxmd.com/read/38455621/one-health-approach-and-zoonotic-diseases-in-indonesia-urgency-of-implementation-and-challenges
#32
REVIEW
I Mdm Adnyana, Budi Utomo, Dwinka S Eljatin, Ni Lg Sudaryati
The urgency of implementing the One Health approach to overcome zoonotic diseases cannot be overstated. By recognizing the interconnectedness of human health, animal health, and the environment, we can effectively prevent and respond to emerging infectious disease threats. This review article provides information on the importance of generating research on zoonotic diseases, especially in Indonesia, where research is still relatively scarce. The Indonesian government has taken steps to implement the One Health by establishing the One Health Coordinating Unit and the National Zoonosis Committee; however, implementation has not been optimal...
December 2023: Narra J
https://read.qxmd.com/read/38451883/hantavirus-pulmonary-syndrome-in-an-adolescent-from-north-dakota
#33
JOURNAL ARTICLE
Ashton D Hall, Danielle Fayad, Mary A Staat
Hantavirus pulmonary syndrome remains an uncommon yet emerging viral zoonosis that causes respiratory failure and hemodynamic instability in children and adolescents. Due to its acutely progressive course and high mortality rate, clinicians treating hantavirus pulmonary syndrome should understand its epidemiologic risk factors, clinical syndrome and radiographic findings. We present a case of hantavirus pulmonary syndrome in a 14-year-old female from North Dakota who survived the infection without sequelae.
February 22, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38448975/lipid-metabolism-the-potential-targets-for-toxoplasmosis-treatment
#34
REVIEW
Tian-Yi He, Ye-Tian Li, Zhen-Di Liu, Hao Cheng, Yi-Feng Bao, Ji-Li Zhang
Toxoplasmosis is a zoonosis caused by Toxoplasma gondii (T. gondii). The current treatment for toxoplasmosis remains constrained due to the absence of pharmaceutical interventions. Thus, the pursuit of more efficient targets is of great importance. Lipid metabolism in T. gondii, including fatty acid metabolism, phospholipid metabolism, and neutral lipid metabolism, assumes a crucial function in T. gondii because those pathways are largely involved in the formation of the membranous structure and cellular processes such as division, invasion, egress, replication, and apoptosis...
March 6, 2024: Parasites & Vectors
https://read.qxmd.com/read/38448148/getting-around-the-roundworms-identifying-knowledge-gaps-and-research-priorities-for-the-ascarids
#35
JOURNAL ARTICLE
Adrian J Wolstenholme, Erik C Andersen, Shivani Choudhary, Friederike Ebner, Susanne Hartmann, Lindy Holden-Dye, Sudhanva S Kashyap, Jürgen Krücken, Richard J Martin, Ankur Midha, Peter Nejsum, Cedric Neveu, Alan P Robertson, Georg von Samson-Himmelstjerna, Robert Walker, Jianbin Wang, Bradley J Whitehead, Paul D E Williams
The ascarids are a large group of parasitic nematodes that infect a wide range of animal species. In humans, they cause neglected diseases of poverty; many animal parasites also cause zoonotic infections in people. Control measures include hygiene and anthelmintic treatments, but they are not always appropriate or effective and this creates a continuing need to search for better ways to reduce the human, welfare and economic costs of these infections. To this end, Le Studium Institute of Advanced Studies organized a two-day conference to identify major gaps in our understanding of ascarid parasites with a view to setting research priorities that would allow for improved control...
2024: Advances in Parasitology
https://read.qxmd.com/read/38446039/novel-influenza-a-viruses-in-pigs-with-zoonotic-potential-chile
#36
JOURNAL ARTICLE
Rodrigo Tapia, Bárbara Brito, Marco Saavedra, Juan Mena, Tamara García-Salum, Raveen Rathnasinghe, Gonzalo Barriga, Karla Tapia, Victoria García, Sergio Bucarey, Yunho Jang, David Wentworth, Montserrat Torremorell, Víctor Neira, Rafael A Medina
Novel H1N2 and H3N2 swine influenza A viruses (IAVs) have recently been identified in Chile. The objective of this study was to evaluate their zoonotic potential. We perform phylogenetic analyses to determine the genetic origin and evolution of these viruses, and a serological analysis to determine the level of cross-protective antibodies in the human population. Eight genotypes were identified, all with pandemic H1N1 2009-like internal genes. H1N1 and H1N2 were the subtypes more commonly detected. Swine H1N2 and H3N2 IAVs had hemagglutinin and neuraminidase lineages genetically divergent from IAVs reported worldwide, including human vaccine strains...
March 6, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38442429/case-report-toxocariasis-manifesting-as-eosinophilic-pleural-effusion
#37
JOURNAL ARTICLE
Takahiro Minamii, Hiroaki Nishioka
Toxocariasis is a prevalent zoonosis caused by infection with the larvae of Toxocara canis or Toxocara cati. It ranges in severity from mundane to life-threatening, depending on organ involvement. The lungs are often affected, manifesting as coughing, wheezing, and chest pain. However, pleural effusions rarely occur in patients with pulmonary toxocariasis. We report the case of a 74-year-old man with highly suspected toxocariasis who presented with an eosinophilic pleural effusion and eosinophilia. He developed dyspnea and a right-sided pleural effusion...
March 5, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38440221/the-current-pathogenicity-and-potential-risk-evaluation-of-marburg-virus-to-cause-mysterious-disease-x-an-update-on-recent-evidences
#38
JOURNAL ARTICLE
Rahima Akter Mitu, Md Rabiul Islam
The World Health Organization (WHO) defined Disease X as an upcoming disease with the potential to cause a pandemic. Pathogen X is responsible for Disease X. Marburg virus disease (MVD) is one of the diseases from the priority disease list published by WHO. Marburg virus is a filamentous, negative-sense RNA virus that belongs to the same filovirus family as the lethal Ebola virus. Since the first discovery of this virus in 1967, 17 outbreaks occurred sporadically till 2023. Rousettus aegyptiacus acts as the natural reservoir of the virus...
2024: Environmental Health Insights
https://read.qxmd.com/read/38435136/hydatid-cyst-of-the-inguinal-region-an-exceptional-localization
#39
Mokhtari Omar, El Mahjoubi Sohaib, Adnane Lachkar, Najib Abdeljaouad, Hicham Yacoubi
Cystic echinococcosis (CE), stemming from the larval stage of the cestode Echinococcus granulosus , stands as a widespread parasitic zoonosis primarily afflicting the liver and lungs. However, instances in the inguinal region are exceptionally infrequent. We present a distinctive case involving a 49-year-old female with a progressively enlarging inguinal mass over a five-year period, characterized by the absence of hepatic or pulmonary involvement. This case underscores the unique clinical presentation and diagnostic intricacies associated with extrahepatic and extrapulmonary expressions of CE...
February 2024: Curēus
https://read.qxmd.com/read/38431113/potent-hydroxamate-derived-compounds-arrest-endodyogeny-of-toxoplasma-gondii-tachyzoites
#40
JOURNAL ARTICLE
Carlla Assis Araujo-Silva, Katharina Vögerl, Ferdinand Breu, Manfred Jung, Andreia Luiza Oliveira Costa, Wanderley De Souza, Franz Bracher, Erica S Martins-Duarte, Rossiane C Vommaro
Toxoplasmosis is a zoonosis that is a worldwide health problem, commonly affecting fetal development and immunodeficient patients. Treatment is carried out with a combination of pyrimethamine and sulfadiazine, which can cause cytopenia and intolerance and does not lead to a parasitological cure of the infection. Lysine deacetylases (KDACs), which remove an acetyl group from lysine residues in histone and non-histone proteins are found in the Toxoplasma gondii genome. Previous work showed the hydroxamate-type KDAC inhibitors Tubastatin A (TST) and Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) were effective against T...
February 29, 2024: Experimental Parasitology
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