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https://www.readbyqxmd.com/read/28817601/bortezomib-initiates-endoplasmic-reticulum-stress-elicits-autophagy-and-death-in-echinococcus-granulosus-larval-stage
#1
María Celeste Nicolao, Julia A Loos, Christian Rodriguez Rodrigues, Viviana Beas, Andrea C Cumino
Cystic echinococcosis (CE) is a worldwide distributed helminthic zoonosis caused by Echinococcus granulosus. Benzimidazole derivatives are currently the only drugs for chemotherapeutic treatment of CE. However, their low efficacy and the adverse effects encourage the search for new therapeutic targets. We evaluated the in vitro efficacy of Bortezomib (Bz), a proteasome inhibitor, in the larval stage of the parasite. After 96 h, Bz showed potent deleterious effects at a concentration of 5 μM and 0.5 μM in protoscoleces and metacestodes, respectively (P < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28811483/the-impact-of-human-population-pressure-on-flying-fox-niches-and-the-potential-consequences-for-hendra-virus-spillover
#2
Michael G Walsh, Anke Wiethoelter, M A Haseeb
Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of inter-decadal net human local migration between 1970 and 2000 on changes in the habitat suitability to P...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807628/vertebral-alveolar-echinococcosis-a-case-report-systematic-analysis-and-review-of-the-literature
#3
REVIEW
Thomas Raphael Meinel, Bruno Gottstein, Vanessa Geib, Marius Johann Keel, Ruggero Biral, Markus Mohaupt, Jan Brügger
Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases...
August 11, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28807304/association-between-mast-cells-tissue-remodelation-and-parasite-burden-in-the-skin-of-dogs-with-visceral-leishmaniasis
#4
Jamille Mirelle de Oliveira Cardoso, Henrique Gama Ker, Rodrigo Dian de Oliveira Aguiar-Soares, Nádia das Dores Moreira, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Bruno Mendes Roatt, Paula Melo de Abreu Vieira, Wendel Coura-Vital, Cláudia Martins Carneiro, Alexandre Barbosa Reis
Canine visceral leishmaniosis (CVL) is a zoonosis of major public health impact caused by organisms of the genus Leishmania which is transmitted to human and animals by phlebotomine sand flies. The skin is the first point of contact with Leishmania parasites for sandy fly vectors and it is considered an important reservoir compartment in infected dogs. The aim of this study was to determine the main histophatologic alterations in ear skin of dogs naturally infected by Leishmania infantum with different clinical status and different degrees of parasitism...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28807274/isolation-of-viable-toxoplasma-gondii-molecular-characterization-and-seroprevalence-in-elk-cervus-canadensis-in-pennsylvania-usa
#5
J P Dubey, J Brown, S K Verma, C K Cerqueira-Cézar, J Banfield, O C H Kwok, Y Ying, F H A Murata, A K Pradhan, C Su
Toxoplasmosis is a worldwide zoonosis. The ingestion of uncooked/undercooked meat and consumption of water contaminated with Toxoplasma gondii oocysts excreted by felids are the main modes of transmission of this parasite. T. gondii has been reported in multiple cervid species; however, little is known of the parasite in North American elk (Cervus canadensis). In the present study, antibodies to T. gondii were detected in serum of wild elk from Pennsylvania collected during 2013-2016 by the modified agglutination test (MAT, cut-off 1:25); 221 of 317 (69...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28803569/detection-of-kobe-type-and-otsu-type-babesia-microti-in-wild-rodents-in-china-s-yunnan-province
#6
Xin-Rong Chen, L I Ye, Jun-Wen Fan, Chang Li, Fang Tang, Wei Liu, Lin-Zhu Ren, Jie-Ying Bai
Babesiosis is an emerging tick-transmitted zoonosis prevalent in large parts of the world. This study was designed to determine the rates of Babesia microti infection among small rodents in Yunnan province, where human cases of babesiosis have been reported. Currently, distribution of Babesia in its endemic regions is largely unknown. In this study, we cataloged 1672 small wild rodents, comprising 4 orders, from nine areas in western Yunnan province between 2009 and 2011. Babesia microti DNA was detected by polymerase chain reaction in 4·3% (72/1672) of the rodents analyzed...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28802946/effects-of-experimental-angiostrongylus-cantonensis-infection-on-the-reproductive-biology-of-biomphalaria-straminea-and-biomphalaria-tenagophila
#7
Mariana G Lima, Vinícius M Tunholi-Alves, Tatiane Cristina S Bonfim, Fabrício N Gaudêncio, Juberlan S Garcia, Arnaldo Maldonado, Jairo Pinheiro, Silvana C Thiengo
Eosinophilic meningoencephalitis is an endemic zoonosis in Southeast Asia and the Pacific Islands, but in recent years, new cases have been reported in various countries outside these regions, including Brazil, where it is considered an emerging disease. In this study, the effect of infection by the nematode Angiostrongylus cantonensis, one of the main etiologic agent of this disease, on the reproductive biology of the planorbid snails Biomphalaria straminea and B. tenagophila was investigated during the pre-patent period...
August 9, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28802826/human-leptospirosis-cases-in-palermo-italy-the-role-of-rodents-and-climate
#8
Maria Vitale, Stefano Agnello, Michele Chetta, Benedetta Amato, Giustina Vitale, Calogero Di Bella, Domenico Vicari, Vincenzo Di Marco Lo Presti
Many regions of the world are increasingly exposed to leptospirosis due to poverty, global warming and high urban density. Here, we report a molecular survey for pathogenic Leptospira spp. in rodents and two symptomatic human cases of leptospirosis in the city of Palermo, Italy. Four rodent species were captured in six areas of the city, and a molecular analysis for pathogenic Leptospira spp. on DNA from the kidney samples showed a different prevalence of leptospirosis in all the species of rodents. In addition, two human cases that occurred in May and October of 2009 in the city were also reported...
August 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28797045/epidemiology-of-bovine-brucellosis-in-costa-rica-lessons-learned-from-failures-in-the-control-of-the-disease
#9
Gabriela Hernández-Mora, Nazareth Ruiz-Villalobos, Roberto Bonilla-Montoya, Juan-José Romero-Zúniga, Julio Jiménez-Arias, Rocío González-Barrientos, Elías Barquero-Calvo, Carlos Chacón-Díaz, Norman Rojas, Esteban Chaves-Olarte, Caterina Guzmán-Verri, Edgardo Moreno
Brucellosis, caused by Brucella abortus is a major disease of cattle and a zoonosis. In order to estimate the bovine brucellosis prevalence in Costa Rica (CR), a total 765 herds (13078 bovines) from six regions of CR were randomly sampled during 2012-2013. A non-random sample of 7907 herds (532199 bovines) of the six regions, arriving for diagnoses during 2014-2016 to the Costa Rican Animal Health Service was also studied. The prevalence estimated by Rose Bengal test (RBT) ranged from 10.5%-11.4%; alternatively, the prevalence estimated by testing the RBT positives in iELISA, ranged from 4...
2017: PloS One
https://www.readbyqxmd.com/read/28796820/identification-of-plasmodium-spp-in-neotropical-primates-of-maranhense-amazon-in-northeast-brazil
#10
Mayra Araguaia Pereira Figueiredo, Silvia Maria Di Santi, Wilson Gómez Manrique, Marcos Rogério André, Rosangela Zacarias Machado
In the Brazilian Amazon region, malaria caused by Plasmodium malariae is considered to be a zoonosis because of cross-transfer of the parasite between humans and Neotropical primates. To contribute information on this issue, we investigated occurrences of natural infection with Plasmodium sp. among Neotropical primates in the Maranhense Amazon (Amazon region of the state of Maranhão), in the northeastern region of Brazil. Blood samples were collected from 161 Neotropical primates of six species that were caught in an environmental reserve (Sítio Aguahy) and from captive primates (CETAS-Wildlife Screening Center, municipality of São Luís), in Maranhão...
2017: PloS One
https://www.readbyqxmd.com/read/28795128/armadillos-an-emerging-zoonosis-in-florida
#11
Jeffrey S Greenwald, Renee Domozych
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28770842/persistent-anthrax-as-a-major-driver-of-wildlife-mortality-in-a-tropical-rainforest
#12
Constanze Hoffmann, Fee Zimmermann, Roman Biek, Hjalmar Kuehl, Kathrin Nowak, Roger Mundry, Anthony Agbor, Samuel Angedakin, Mimi Arandjelovic, Anja Blankenburg, Gregory Brazolla, Katherine Corogenes, Emmanuel Couacy-Hymann, Tobias Deschner, Paula Dieguez, Karsten Dierks, Ariane Düx, Susann Dupke, Henk Eshuis, Pierre Formenty, Yisa Ginath Yuh, Annemarie Goedmakers, Jan F Gogarten, Anne-Céline Granjon, Scott McGraw, Roland Grunow, John Hart, Sorrel Jones, Jessica Junker, John Kiang, Kevin Langergraber, Juan Lapuente, Kevin Lee, Siv Aina Leendertz, Floraine Léguillon, Vera Leinert, Therese Löhrich, Sergio Marrocoli, Kerstin Mätz-Rensing, Amelia Meier, Kevin Merkel, Sonja Metzger, Mizuki Murai, Svenja Niedorf, Hélène De Nys, Andreas Sachse, Joost van Schijndel, Ulla Thiesen, Els Ton, Doris Wu, Lothar H Wieler, Christophe Boesch, Silke R Klee, Roman M Wittig, Sébastien Calvignac-Spencer, Fabian H Leendertz
Anthrax is a globally important animal disease and zoonosis. Despite this, our current knowledge of anthrax ecology is largely limited to arid ecosystems, where outbreaks are most commonly reported. Here we show that the dynamics of an anthrax-causing agent, Bacillus cereus biovar anthracis, in a tropical rainforest have severe consequences for local wildlife communities. Using data and samples collected over three decades, we show that rainforest anthrax is a persistent and widespread cause of death for a broad range of mammalian hosts...
August 2, 2017: Nature
https://www.readbyqxmd.com/read/28764637/invasive-anisakiasis-by-the-parasite-anisakis-pegreffii-nematoda-anisakidae-diagnosis-by-real-time-pcr-hydrolysis-probe-system-and-immunoblotting-assay
#13
Simonetta Mattiucci, Michela Paoletti, Alessandra Colantoni, Antonella Carbone, Raffaele Gaeta, Agnese Proietti, Stefano Frattaroli, Paolo Fazii, Fabrizio Bruschi, Giuseppe Nascetti
BACKGROUND: Anisakiasis is a fish-borne zoonosis caused by Anisakis spp. larvae. One challenging issue in the diagnosis of anisakiasis is the molecular detection of the etiological agent even at very low quantity, such as in gastric or intestinal biopsy and granulomas. Aims of this study were: 1) to identify three new cases of invasive anisakiasis, by a species-specific Real-time PCR probe assay; 2) to detect immune response of the patients against the pathogen. METHODS: Parasite DNA was extracted from parasites removed in the three patients...
August 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28761463/the-33-1-kda-excretory-secretory-protein-produced-by-toxocara-canis-larvae-serves-as-a-potential-common-biomarker-for-serodiagnosis-of-toxocariasis-in-paratenic-animals-and-human
#14
Huu-Hung Nguyen, Doan-Trung Vo, Thi-Tuyet-Trinh Thai, Thi-Thanh-Thao LE, Thanh-Dong LE, Nghia-Son Hoang
BACKGROUND: Toxocariasis is a prevalent zoonosis disease caused by the closely related nematode species Toxocara canis and Toxocara cati which parasitise Canidae and Felidae respectively. In paratenic hosts, larvae of these worms cause multiple organ damage. However, how these paratenic hosts response to these worms and whether any common biomarker can be applied for diagnosis are still unclear. METHODS: Excreted/secreted (E/S) antigens were prepared by culture of T...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28759462/pig-islet-xenotransplantation
#15
Maheswaran Dhanasekaran, Johnathan J George, Gopalakrishnan Loganathan, Siddharth Narayanan, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan
PURPOSE OF REVIEW: The current article reviews the rationale, sources and preparation of pig islets for xenotransplantation, and presents current progress in solving the problems associated with establishing pig islet transplant as a clinical treatment for type 1 diabetes. SUMMARY: Islet transplantation is an effective treatment option for type 1 diabetes, but the available supply of human pancreases is insufficient to meet the need and demand for obtaining islets...
July 28, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28759251/toxoplasma-gondii-a-foodborne-pathogen-in-the-swine-production-chain-from-a-european-perspective
#16
Alberto De Berardinis, Domenico Paludi, Luca Pennisi, Alberto Vergara
Toxoplasmosis is a foodborne zoonosis transmitted by Toxoplasma gondii, a cosmopolitan protozoan that infects humans through exposure to different parasite stages, in particular by ingestion of tissue cysts or tachyzoites contained in meat, primary offal (viscera), and meat-derived products or ingestion of environmental sporulated oocysts in contaminated food or water. The pig is an important species for infection: raw or undercooked pork consumption not subject to treatment able to inactivate the parasite represents a risk to consumers' health...
July 31, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28757013/a-haplotype-at-intron-8-of-ptprt-gene-is-associated-with-resistance-to-brucella-infection-in-argentinian-creole-goats
#17
Ursula A Rossi, Flavia C Hasenauer, Maria E Caffaro, Roberto Neumann, Antonio Salatin, Mario A Poli, Carlos A Rossetti
Brucellosis is the leading zoonosis on a worldwide scale and constitutes a major public health threat in many regions of the world. Several molecular markers associated with natural resistance to intracellular bacterial infection have been identified. Recently seven single-nucleotide polymorphisms (SNPs) located in the PTPRT gene were associated with resistance to Mycobacterium bovis infection in cattle. Here, we perform a case-control study to test if polymorphisms at PTPRT intron 8 might influence the resistance or susceptibility to Brucella infection in goats...
August 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28754266/detection-of-anti-leptospira-inhibitory-antibodies-in-horses-after-vaccination
#18
Lucas Correia, Gabriel Martins, Walter Lilenbaum
Leptospirosis is a relevant zoonosis that affects the reproductive performance of livestock, impairing the economy. Few studies have demonstrated the effects of vaccination against leptospirosis on naturally exposed horses. This study aimed to detect anti-Leptospira inhibitory antibodies in horses after vaccination. A total of 54 mares were studied using Growth Inhibition Test (GIT) in three moments. The present results demonstrate the usefulness of GIT for confirming inhibitory effects of specific antibody production...
July 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28748783/detection-of-echinococcus-multilocularis-and-other-foodborne-parasites-in-fox-cat-and-dog-faeces-collected-in-kitchen-gardens-in-a-highly-endemic-area-for-alveolar-echinococcosis
#19
Marie-Lazarine Poulle, Matthieu Bastien, Yolan Richard, Émilie Josse-Dupuis, Dominique Aubert, Isabelle Villena, Jenny Knapp
Echinococcus multilocularis, Toxoplasma gondii and Toxocara spp. are foodborne parasites whose eggs or oocysts are spread in the environment via canid or felid faeces. They can cause infections in humans following the raw consumption of contaminated fruit or vegetables. In this study, their occurrence was investigated by quantitative polymerase chain reaction (qPCR) in 254 carnivore faeces deposited in 94 kitchen gardens of northeastern France that were sampled between two and six times from October 2011 to April 2013...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28746328/unresolving-pneumonia-with-pleural-effusion-pulmonary-paragonimiasis
#20
D Gaire, S Sharma, K Poudel, P Pant
Paragonimiasis is a zoonosis caused by many species of Paragonimus commonly P. westermani. Human get infected by eating raw, salted, pickled, smoked, partially cooked crustaceans (crayfish or crabs). Clinical manifestations ranges from non-specific symptoms like pain abdomen, diarrhea, urticarial rashes, fever to pleuropulmonary symptoms like cough, hemoptysis, chest pain and dyspnea. A 48 years, female presented at TUTH emergency with fever on and off for nine months, cough and shortness of breath for three months, lethargy, malaise and urticaria with history of raw crab intake one month prior to the onset of symptoms...
April 2017: JNMA; Journal of the Nepal Medical Association
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