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https://www.readbyqxmd.com/read/28212901/the-dissociation-of-the-hsp60-pro-caspase-3-complex-by-bis-pyridyl-oxadiazole-copper-complex-cubipyoxa-leads-to-cell-death-in-nci-h292-cancer-cells
#1
Celeste Caruso Bavisotto, Dragana Nikolic, Antonella Marino Gammazza, Rosario Barone, Filippa Lo Cascio, Emanuele Mocciaro, Giovanni Zummo, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello, Valentina Giacalone, Andrea Pace, Giampaolo Barone, Antonio Palumbo Piccionello, Claudia Campanella
Cell survival and proliferation are central to carcinogenesis, involving various mechanisms among which those that impede apoptosis are important. In this, the role of the molecular chaperone Hsp60 is unclear since it has been reported that it can be both, pro- or anti-apoptotic. A solution to this riddle is crucial to the development of anti-cancer therapies targeting Hsp60. We addressed this question using a tumor cell line, NCI-H292, and [Cu(3,5-bis(2'-pyridyl)-1,2,4-oxadiazole)2(H2O)2](ClO4)2, CubipyOXA, a copper-containing compound with cytotoxic properties...
February 10, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28212477/-hyponatremia-and-its-etiology-in-pediatric-patients-admitted-to-the-emergency-room
#2
Alma Beatriz Medrano-Rodríguez, Rosa Ortega-Cortés, Elvira Torres-Infante, Alejandro Macario-Reynoso, Juan Carlos Barrera-de León
BACKGROUND: The importance of hyponatremia is underestimated despite it is a frequent alteration in a hospital environment. Usually no cause is investigated and it is treated as an isolated data. The aim was to determine the prevalence and etiology of hyponatremia in pediatric patients. METHODS: Cross-sectional study of 72 patients from 1-month to 15-years of age admitted to the emergency room, from May to September, 2015, with lower serum determination of Na < 135 mEq/L at admission...
2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28201808/laser-assisted-uvulopalatoplasty-laup-for-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#3
Macario Camacho, Nicholas B Nesbitt, Evan Lambert, Sungjin A Song, Edward T Chang, Stanley Yung Liu, Clete A Kushida, Soroush Zaghi
No abstract text is available yet for this article.
February 15, 2017: Sleep
https://www.readbyqxmd.com/read/28190371/occupational-radiation-exposure-of-anesthesia-providers
#4
Rachel R Wang, Amanda H Kumar, Pedro Tanaka, Alex Macario
Anesthesia providers are frequently exposed to radiation during routine patient care in the operating room and remote anesthetizing locations. Eighty-two percent of anesthesiology residents (n = 57 responders) at our institution had a "high" or "very high" concern about the level of ionizing radiation exposure, and 94% indicated interest in educational materials about radiation safety. This article highlights key learning points related to basic physical principles, effects of ionizing radiation, radiation exposure measurement, occupational dose limits, considerations during pregnancy, sources of exposure, factors affecting occupational exposure such as positioning and shielding, and monitoring...
February 1, 2017: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28169045/sleep-surgery-tool-a-medical-checklist-to-review-prior-to-operating
#5
Macario Camacho, Robert W Riley, Robson Capasso, Peter O'Connor, Edward T Chang, Lauren K Reckley, Christian Guilleminault
OBJECTIVE: The objective of this study was to systematically review the international literature for studies providing a preoperative checklist for medical disorders to be evaluated or treated before performing sleep surgery. If no checklist exists, then studies providing recommendations would be used to develop a checklist de novo. STUDY DESIGN: Systematic review combined with expert opinion. METHODS: Four databases, including PubMed/Medline were searched through August 10, 2016...
January 10, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28130737/dexmedetomidine-versus-propofol-during-drug-induced-sleep-endoscopy-and-sedation-a-systematic-review
#6
REVIEW
Edward T Chang, Victor Certal, Sungjin A Song, Soroush Zaghi, Marina Carrasco-Llatas, Carlos Torre, Robson Capasso, Macario Camacho
BACKGROUND: The purpose of the present study is to review the international literature, using a systematic review, for studies comparing propofol and dexmedetomidine for drug-induced sleep endoscopy (DISE) or sedation in which there is a description of the effect of the agents on the upper airway and associated variables (e.g., vital signs, sedation scores). METHODS: This is a systematic review through October 4, 2016. PubMed/MEDLINE and four additional databases were accessed for this study...
January 27, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28100128/multidisciplinary-sleep-clinic-a-patient-centered-approach
#7
Macario Camacho, Michael J Ryhn, Christine S Fukui, Jennifer M Bager
No abstract text is available yet for this article.
March 2017: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/28099326/implementation-of-a-needs-based-online-feedback-tool-for-anesthesia-residents-with-subsequent-mapping-of-the-feedback-to-the-acgme-milestones
#8
Pedro Tanaka, Sylvia Bereknyei Merrell, Kim Walker, Jennifer Zocca, Lena Scotto, Alyssa L Bogetz, Alex Macario
BACKGROUND: Optimizing feedback that residents receive from faculty is important for learning. The goals of this study were to (1) conduct focus groups of anesthesia residents to define what constitutes optimal feedback; (2) develop, test, and implement a web-based feedback tool; and (3) then map the contents of the written comments collected on the feedback tool to the Accreditation Council for Graduate Medical Education (ACGME) anesthesiology milestones. METHODS: All 72 anesthesia residents in the program were invited to participate in 1 of 5 focus groups scheduled over a 2-month period...
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28095968/catathrenia-nocturnal-groaning-a-social-media-survey-and-state-of-the-art-review
#9
Jose Alonso, Macario Camacho, Dinesh K Chhetri, Christian Guilleminault, Soroush Zaghi
STUDY OBJECTIVES: Catathrenia is an underrecognized nocturnal vocalization phenomenon that can be a source of perplexity to patients, bed partners, and medical providers. Catathrenia is distinct from both sleep talking (a parasomnia with loud talking during sleep) and snoring (noise due to vibration of upper airway soft tissues related to variations in airway resistance). The objective of this review is to provide an evidence-based resource to help the practitioner reliably evaluate and manage patients with this condition...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28089320/advances-in-operating-room-management-the-role-of-operating-room-director
#10
L E Muñoz Alameda, A Macario
No abstract text is available yet for this article.
January 12, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28027978/in-silico-analysis-for-predicting-pathogenicity-of-five-unclassified-mitochondrial-dna-mutations-associated-with-mitochondrial-cytopathies-phenotypes
#11
Mafalda Bacalhau, João Pratas, Marta Simões, Cândida Mendes, Carolina Ribeiro, Maria J Santos, Luísa Diogo, Maria Carmo Macário, Manuela Grazina
Mitochondrial DNA (mtDNA) mutations have been assigned as a major cause of genetic disease. When a novel sequence variation is found, it is necessary to evaluate its functional impact, usually requiring functional molecular studies. Given the fact that this approach is difficult to put in practice in a routine basis, it is possible to take advantage of the in silico tools available and predict protein/RNA structure changes and therefore pathogenicity. Here, we describe the characterization of five undescribed mtDNA variants, upon detection of 23 unclassified alterations at Laboratory of Biochemical Genetics, from 2004 to 2014...
March 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27972566/impact-of-surgical-technique-on-length-of-stay-and-early-outcomes-in-breast-reconstruction-a-preliminary-analysis
#12
A Gabriel, S R Sigalove, L Griffin, M H Parekh, D Macarios, G P Maxwell
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27957370/refractory-obstructive-sleep-apnea-in-a-patient-with-diffuse-idiopathic-skeletal-hyperostosis
#13
Ara Darakjian, Ani B Darakjian, Edward T Chang, Macario Camacho
Diffuse Idiopathic Skeletal Hyperostosis (DISH) can cause ossification of ligaments and may affect the spine. We report a case of obstructive sleep apnea in a patient with significant upper airway narrowing secondary to cervical DISH. This patient had an initial apnea-hypopnea index (AHI) of 145 events/hour and was treated with uvulopalatopharyngoplasty, genial tubercle advancement, hyoid suspension, septoplasty, inferior turbinoplasties, and radiofrequency ablations to the tongue base which reduced his AHI to 40 events/hour...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27930385/questions-regarding-statistical-inferences-quality-of-life-and-conclusions-from-the-cobra-study
#14
David Macarios, Ronald P Silverman
No abstract text is available yet for this article.
December 7, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27914385/beamforming-pointing-error-of-a-triaxial-velocity-sensor-under-gain-uncertainties
#15
Tsair-Chuan Lin, Kainam Thomas Wong, Macario O Cordel, Joel Paz Ilao
A "triaxial velocity sensor" consists of three uniaxial velocity sensors, which are nominally identical, orthogonally oriented among themselves, and co-centered at one point in space. A triaxial velocity sensor measures the acoustic particle velocity vector, by its three Cartesian components, individually component-by-component, thereby offering azimuth-elevation two-dimensional spatial directivity, despite the physical compactness that comes with the collocation of its three components. This sensing system's azimuth-elevation beam-pattern has been much analyzed in the open literature, but only for an idealized case of the three uniaxial velocity sensors being exactly identical in gain...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27875929/introducing-a-new-concept-in-obstructive-sleep-apnea-the-continuum-of-treatment
#16
Victor Certal, Macario Camacho, Sungjin A Song, Robson Capasso
No abstract text is available yet for this article.
November 22, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27864177/histone-deacetylase-hda-2-regulates-trichoderma-atroviride-growth-conidiation-blue-light-perception-and-oxidative-stress-responses
#17
Macario Osorio-Concepción, Gema Rosa Cristóbal-Mondragón, Braulio Gutiérrez-Medina, Sergio Casas-Flores
: Fungal blue-light photoreceptors have been proposed as integrators of light and oxidative stress. However, additional elements participating in the integrative pathway remain to be identified. In Trichoderma atroviride, the blue-light regulator (BLR) proteins BLR-1 and -2 are known to regulate gene transcription, mycelial growth, and asexual development upon illumination, and recent global transcriptional analysis revealed that the histone deacetylase-encoding gene hda-2 is induced by light...
February 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27860021/detection-of-leishmania-amazonensis-and-leishmania-braziliensis-in-culicoides-diptera-ceratopogonidae-in-an-endemic-area-of-cutaneous-leishmaniasis-in-the-brazilian-amazonia
#18
José Manuel Macário Rebêlo, Bruno Leite Rodrigues, Maria da Conceição Abreu Bandeira, Jorge Luiz Pinto Moraes, Raquel Silva Fonteles, Silma Regina Ferreira Pereira
Biting midges in the genus Culicoides act as vectors of arboviruses throughout the world and as vectors of filariasis in Latin America, the Caribbean, and parts of Africa. Although Culicoides spp. are currently not considered to be vectors of Leishmania protozoa, the high abundance of biting midges in areas with active cutaneous leishmaniasis transmission points to the possibility of Culicoides infection by these pathogens. We used PCR to test captured Culicoides species for natural infection with Leishmania spp...
December 2016: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/27843736/does-faculty-follow-the-recommended-structure-for-a-new-classroom-based-daily-formal-teaching-session-for-anesthesia-residents
#19
Anjum Anwar, Pedro Tanaka, Matias V Madsen, Alex Macario
BACKGROUND:  A newly implemented 15-minute classroom-based, formal teaching session for anesthesia residents is given three times daily by the same faculty. The faculty member was provided a suggested template for the presentation. The template structure was developed by a group of residents and faculty to include best teaching practices. The goal of the current study was to measure how frequently the faculty teaching these sessions followed the template. METHODS: From February 20, 2015 to February 6, 2016, a research assistant trained in education mapped a total of 48 teaching sessions to determine how frequently the teaching sessions included each of the elements in the recommended template structure...
October 6, 2016: Curēus
https://www.readbyqxmd.com/read/27836734/doxorubicin-anti-tumor-mechanisms-include-hsp60-post-translational-modifications-leading-to-the-hsp60-p53-complex-dissociation-and-instauration-of-replicative-senescence
#20
Antonella Marino Gammazza, Claudia Campanella, Rosario Barone, Celeste Caruso Bavisotto, Magdalena Gorska, Michal Wozniak, Francesco Carini, Francesco Cappello, Antonella D'Anneo, Marianna Lauricella, Giovanni Zummo, Everly Conway de Macario, Alberto J L Macario, Valentina Di Felice
The chaperone Hsp60 is pro-carcinogenic in certain tumor types by interfering with apoptosis and with tumor cell death. In these tumors, it is not yet known whether doxorubicin anti-tumor effects include a blockage of the pro-carcinogenic action of Hsp60. We found a doxorubicin dose-dependent viability reduction in a human lung mucoepidermoid cell line that was paralleled by the appearance of cell senescence markers. Concomitantly, intracellular Hsp60 levels decreased while its acetylation levels increased...
January 28, 2017: Cancer Letters
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