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https://www.readbyqxmd.com/read/29328973/feeding-inhibition-in-corbicula-fluminea-o-f-muller-1774-as-an-effect-criterion-to-pollutant-exposure-perspectives-for-ecotoxicity-screening-and-refinement-of-chemical-control
#1
Bruno Branco Castro, Carlos Silva, Inês Patrunilho Efe Macário, Bruno Oliveira, Fernando Gonçalves, Joana Luísa Pereira
Bivalves are commonly used in biomonitoring programs to track pollutants. Several features, including its filter-feeding abilities, cumulatively argue in favour of the use of the Asian clam (Corbicula fluminea) as a biosentinel and an ecotoxicological model. Filtration in bivalves is very sensitive to external stimuli and its control is dictated by regulation of the opening/closure of the valves, which may be used as an avoidance defence against contaminants. Here, we investigate the filter-feeding behaviour of the Asian clam as an endpoint for assessing exposure to pollutants, driven by two complementary goals: (i) to generate relevant and sensitive toxicological information based on the ability of C...
January 4, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29314068/publication-trends-and-levels-of-evidence-in-obstructive-sleep-apnea-literature
#2
Christopher J Gouveia, Soroush Zaghi, Michael Awad, Macario Camacho, Stanley Y C Liu, Robson Capasso, Robert C Kern
OBJECTIVES/HYPOTHESIS: Examine trends in clinical research and levels of evidence related to obstructive sleep apnea (OSA) in the medical literature. Describe the features and trends of OSA research within otolaryngology journals. STUDY DESIGN: Retrospective analysis. METHODS: Review of OSA research articles from 2006, 2011, and 2016 in four leading medical sleep and otolaryngology journals. Level of evidence was graded, and study characteristics were measured...
January 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29281057/detection-of-leishmania-dna-and-blood-meal-identification-in-sand-flies-diptera-psychodidae-from-len%C3%A3-ois-maranhenses-national-park-region-brazil
#3
Raquel Silva Fonteles, Adalberto Alves Pereira Filho, Jorge Luiz Pinto Moraes, Silma Regina Ferreira Pereira, Bruno Leite Rodrigues, José Manuel Macário Rebêlo
To elucidate portions of the transmission cycles of American tegumentary leishmaniasis (TL) and visceral leishmaniasis (VL) occurring in the region surrounding the Lençóis Maranhenses National Park, an important tourist center in Brazil, the present study objectives were to determine the rate of natural infection by Leishmania spp. and the blood meal in caught sand flies species in the region. Sand flies were captured over 36 mo in 62 locations of the municipality of Barreirinhas, Maranhão with notifications of disease incidence...
December 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29280292/hypopharyngeal-evaluation-in-obstructive-sleep-apnea-with-awake-flexible-laryngoscopy-validation-and-updates-to-cormack-lehane-and-modified-cormack-lehane-scoring-systems
#4
Carlos Torre, Soroush Zaghi, Macario Camacho, Robson Capasso, Stanley Yung-Chuan Liu
OBJECTIVE: To validate the use of Cormack-Lehane and Modified Cormack-Lehane scoring systems to classify patterns of hypopharyngeal airway visualization seen during awake flexible laryngoscopy among patients with obstructive sleep apnea. STUDY DESIGN: Validation study using samples collected from a prospective database. SETTING: University Medical Center. PARTICIPANTS: Data was obtained from a retrospective review of a prospective database of flexible fiberoptic examination recordings in 274 consecutive OSA subjects (Stanford Sleep Medicine/Surgery Clinic)...
December 26, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29275425/oropharyngeal-and-tongue-exercises-myofunctional-therapy-for-snoring-a-systematic-review-and-meta-analysis
#5
REVIEW
Macario Camacho, Christian Guilleminault, Justin M Wei, Sungjin A Song, Michael W Noller, Lauren K Reckley, Camilo Fernandez-Salvador, Soroush Zaghi
PURPOSE: Oropharyngeal and tongue exercises (myofunctional therapy) have been shown to improve obstructive sleep apnea. However, to our knowledge, a systematic review has not been performed for snoring. The study objective is to perform a systematic review, with a meta-analysis, dedicated to snoring outcomes after myofunctional therapy. METHODS: PubMed/MEDLINE and three other databases were searched through November 25, 2017. Two authors independently searched the literature...
December 23, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29241141/plasma-exchange-in-severe-acute-relapses-of-multiple-sclerosis-results-from-a-portuguese-cohort
#6
Inês Correia, Joana Jesus Ribeiro, Luís Isidoro, Sónia Batista, Carla Nunes, Carmo Macário, Catarina Borges, Jorge Tomaz, Lívia Sousa
BACKGROUND: Relapses in Multiple Sclerosis (MS) are often associated with significant disability impairment which is resultant from poor response to corticosteroids. In such severe cases, plasma exchange (PLEX) may be used, although only a few studies with MS patients have been reported. Our objective was to evaluate the effectiveness of PLEX in severe relapses of MS. METHODS: Retrospective study of MS patients treated with PLEX in acute relapses. Data regarding EDSS, annualized relapse rate (ARR), treatment with corticosteroids, number of PLEX sessions, adverse events, and gadolinium enhancement in brain MRI were analysed...
December 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29209368/corrigendum-to-prevalence-of-fracture-risk-factors-in-postmenopausal-women-enrolled-in-the-possible-us-treatment-cohort
#7
Nicole Yurgin, Sally Wade, Sacha Satram-Hoang, David Macarios, Marc Hochberg
[This corrects the article DOI: 10.1155/2013/715025.].
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29177667/immunohistochemistry-of-human-hsp60-in-health-and-disease-from-autoimmunity-to-cancer
#8
Francesco Cappello, Everly Conway de Macario, Francesca Rappa, Giovanni Zummo, Alberto J L Macario
Hsp60 (also called Cpn60) is a chaperonin with essential functions for cell physiology and survival. Additionally, its involvement in the pathogenesis of a variety of diseases (e.g., some autoimmune disorders and cancer) is becoming evident with new research. For example, the distribution and levels of Hsp60 in cells and tissues have been found altered in many pathologic conditions, and the significance of these alterations is being investigated in a number of laboratories. The aim of this ongoing research is to determine the meaning of these Hsp60 alterations with regard to pathogenetic mechanisms, diagnosis, classification of lesions, and assessing prognosis and response to treatment...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29170995/correction-to-stepwise-strategy-for-monitoring-toxic-cyanobacterial-blooms-in-lentic-water-bodies
#9
Inês P E Macário, Bruno B Castro, Maria I S Nunes, Cristina Pizarro, Carla Coelho, Fernando Gonçalves, Daniela R de Figueiredo
Unfortunately, the name of the third author was incorrectly captured in the published online paper.
November 23, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29124450/stepwise-strategy-for-monitoring-toxic-cyanobacterial-blooms-in-lentic-water-bodies
#10
Inês P E Macário, Bruno B Castro, Isabel M S Nunes, Cristina Pizarro, Carla Coelho, Fernando Gonçalves, Daniela R de Figueiredo
Climate change has been causing the increase in frequency, severity, and duration of harmful algal blooms, which makes the establishment of water management strategies indispensable. For cyanobacteria, several methods are currently used in monitoring programs. However, these methods are time-consuming and require specialists, and results are usually not provided within an adequate timeframe for taking timely mitigation actions. This work proposes a strategy for a faster, easier, and more cost-effective monitoring of cyanobacterial blooms, using a stepwise approach based on fluorometric determination of phycocyanin at an early stage...
November 9, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29113702/mandibular-advancement-for-adult-obstructive-sleep-apnea-a%C3%A2-systematic-review-and-meta-analysis
#11
REVIEW
Michael W Noller, Christian Guilleminault, Christopher J Gouveia, Douglas Mack, Charles Vivian, Jose Abdullatif, Stefano Mangili, Stanley Yung Liu, Soroush Zaghi, Macario Camacho
OBJECTIVES: Patients with mandibular insufficiency can be predisposed to obstructive sleep apnea (OSA). The objective of this study was to systematically review the international literature for mandibular advancement surgeries (MAS) as treatment for adult OSA, and then to perform a meta-analysis. METHODS: Four authors searched five databases from the inception of each database through April 5, 2017. The PRISMA statement was followed. RESULTS: 972 studies were screened, 84 were downloaded, and 11 (57 patients) met criteria...
October 13, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29099607/comparison-of-2017-and-2015-global-initiative-for-obstructive-lung-disease-impact-on-grouping-and-outcomes
#12
Carlos Cabrera López, Ciro Casanova Macario, José María Marín Trigo, Juan P de-Torres, Rebeca Sicilia Torres, Jesús María González, Francesca Polverino, Miguel Divo, Victor Pinto Plata, Javier J Zulueta, Bartolomé Celli
INTRODUCTION: The GOLD document has modified the grading system directing pharmacotherapy. But how this relates to the previous one of 2015 and to comorbidities, hospitalizations and mortality risk is unknown. METHODS: We prospectively enrolled and followed for a mean of 5 years, 819 COPD patients (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV1%), dyspnea score (mMRC), ambulatory and hospital exacerbations, the BODE and Charlson indexes...
November 3, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29075401/health-in-residency-the-dilemma-of-caring-for-yourself
#13
EDITORIAL
Justin M Wei, Camilo Fernandez-Salvador, Macario Camacho
No abstract text is available yet for this article.
October 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29055477/pregnancy-in-multiple-sclerosis-a-portuguese-cohort-study
#14
Joana Jesus-Ribeiro, Inês Correia, Ana Inês Martins, Manuel Fonseca, Inês Marques, Sónia Batista, Carla Nunes, Carmo Macário, Maria Céu Almeida, Lívia Sousa
BACKGROUND: Pregnancy in Multiple Sclerosis (MS) has been a controversial issue, without international standardized treatment recommendations. The goal of our study was to evaluate the clinical course of MS during pregnancy and the respective therapeutic options, obstetrical outcomes and breastfeeding data. METHODS: This was a retrospective study including women with a diagnosis of relapsing-remitting MS at least one year before pregnancy. Three periods were evaluated: one year prior to pregnancy, pregnancy and one year postpartum...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29016633/apparent-survival-and-cost-of-reproduction-for-white-lined-tanager-tachyphonus-rufus-thraupidae-in-the-northern-atlantic-rainforest-brazil
#15
Phoeve Macario, Mauro Pichorim, Paul F Doherty, Guilherme S Toledo-Lima, Tonny M Oliveira-Júnior, Thanyria P F Câmara, Shirley Macjane Melo, João Lucas S Silveira, Juliana C Araújo, Leonardo F França
Understanding latitudinal variation in avian life-history traits has been a focus of many demographic studies around the world. However, we still know little about annual or intra-annual demographic variation within tropical regions or about how factors such as breeding season and precipitation influence demographic rates. In this study, we estimated intra-annual apparent survival of the White-lined Tanager (Tachyphonus rufus) using capture-mark-recapture data from northeastern Brazil. We tested whether survival varied seasonally (breeding vs...
2017: PloS One
https://www.readbyqxmd.com/read/28976240/hsp60-activity-on-human-bronchial-epithelial-cells
#16
Claudia Sangiorgi, Davide Vallese, Isabella Gnemmi, Fabio Bucchieri, Bruno Balbi, Paola Brun, Angelo Leone, Andrea Giordano, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello, Antonino Di Stefano
HSP60 has been implicated in chronic inflammatory disease pathogenesis, including chronic obstructive pulmonary disease (COPD), but the mechanisms by which this chaperonin would act are poorly understood. A number of studies suggest a role for extracellular HSP60, since it can be secreted from cells and bind Toll-like receptors; however, the effects of this stimulation have never been extensively studied. We investigated the effects (pro- or anti-inflammatory) of HSP60 in human bronchial epithelial cells (16-HBE) alone and in comparison with oxidative, inflammatory, or bacterial challenges...
October 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28926334/family-phenotypic-heterogeneity-caused-by-mitochondrial-dna-mutation-a3243g
#17
Daniela Alves, Maria Eufémia Calmeiro, Carmo Macário, Rosa Silva
Maternally inherited diabetes and deafness is a rare form of diabetes caused by a mitochondrial DNA mutation. The index case is a 55-year-old woman who was admitted with hypertrophic cardiomyopathy. She had a history of diabetes mellitus and hearing loss. The patient's mother, two brothers and two sisters also had a history of diabetes and hearing loss. This pattern suggests a maternally inherited disorder. All siblings carried the A3243G mitochondrial DNA mutation. The identification of people with monogenic forms of diabetes mellitus is a diagnostic challenge...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28903546/cellular-and-molecular-mechanisms-of-viral-infection-in-the-human-placenta
#18
Moises León-Juárez, Macario Martínez-Castillo, Luis Didier González-García, Addy Cecilia Helguera-Repetto, Verónica Zaga-Clavellina, Julio García-Cordero, Arturo Flores-Pliego, Alma Herrera-Salazar, Edgar Ricardo Vázquez-Martínez, Enrique Reyes-Muñoz
The placenta is a highly specialized organ that is formed during human gestation for conferring protection and generating an optimal microenvironment to maintain the equilibrium between immunological and biochemical factors for fetal development. Diverse pathogens, including viruses, can infect several cellular components of the placenta, such as trophoblasts, syncytiotrophoblasts and other hematopoietic cells. Viral infections during pregnancy have been associated with fetal malformation and pregnancy complications such as preterm labor...
September 29, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28844615/anti-jcv-antibody-serostatus-and-longitudinal-evaluation-in-a-portuguese-multiple-sclerosis-population
#19
I Correia, J Jesus-Ribeiro, S Batista, A I Martins, C Nunes, M C Macário, L Cunha, L Sousa
Multiple Sclerosis (MS) treatment with natalizumab is associated with Progressive Multifocal Leukoencephalopathy (PML). The risk of PML being related to the anti-JCV antibody index is well established, but there is less known about seroconversion rates in natalizumab-treated patients and longitudinal variation in the anti-JCV antibody index. Our objective was to assess anti-JCV antibody prevalence in an MS population and to evaluate the evolution of the anti-JCV antibody index in natalizumab-treated patients...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28837565/leishmania-infection-and-blood-food-sources-of-phlebotomines-in-an-area-of-brazil-endemic-for-visceral-and-tegumentary-leishmaniasis
#20
Antônia Suely Guimarães-E-Silva, Soraia de Oliveira Silva, Rosa Cristina Ribeiro da Silva, Valéria Cristina Soares Pinheiro, José Manuel Macário Rebêlo, Maria Norma Melo
The aims of the study were to determine the blood feeding preferences of sandflies and to identify species of Leishmania that infected phlebotomines in Caxias, Maranhão, Brazil, an area that is highly endemic for leishmaniasis. Sandflies were captured in light traps located in the peridomiciliary environments of randomly selected houses in urban and rural settings between 1800 and 0600 hours on new moon days between March 2013 and February 2015. DNA extracts from 982 engorged female sandflies were submitted to fragment length polymorphism analysis to identify infecting species of Leishmania, and blood sources were identified for 778 of these specimens...
2017: PloS One
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