Read by QxMD icon Read


C O Brito, J L L Dutra, T N Dias, L T Barbosa, C S Nascimento, A P G Pinto, L F T Albino, R P M Fernandes, M S Macário, J S Melo
The aim of this study was to evaluate the effect of dietary lysine on performance, protein deposition and respiratory chain gene expression in male broilers. A total of 252 Cobb 500 broilers were distributed, in a completely randomized design, into four treatments with seven replicates of nine birds per experimental unit. Experimental treatments consisted of diets based on corn and soybean meal, with four levels of digestible lysine: 1.016%, 1.099%, 1.182% and 1.265%. The increase in the level of digestible lysine in the diet provided higher weight gains, feed efficiency and body protein deposition...
October 21, 2016: Animal: An International Journal of Animal Bioscience
Carolina Ribeiro, Maria do Carmo Macário, Ana Teresa Viegas, João Pratas, Maria João Santos, Marta Simões, Cândida Mendes, Mafalda Bacalhau, Paula Garcia, Luísa Diogo, Filipe Silva, Manuela Grazina
Leigh syndrome (LS) is a rare, progressive neurodegenerative mitochondrial disorder of infancy. It is a genetically heterogeneous disease. The mutations in SURF1 gene are the most frequently known cause. Here two cases of LS likely caused by SURF1 gene variants are reported: a 39-year-old male patient with a novel homozygous deletion (c.-11_13del), and a case of a 6-year-old boy with the same deletion and a nonsense mutation (c.868dupT), both in heterozygosity. Blue native PAGE showed absence of assembled complex IV...
October 15, 2016: Mitochondrion
Allen Gabriel, G Patrick Maxwell, Leah Griffin, Manish C Champaneria, Mousam Parekh, David Macarios
BACKGROUND: Centrifugation (Cf) is a common method of fat processing but may be time consuming, especially when processing large volumes. OBJECTIVES: To determine the effects on fat grafting time, volume efficiency, reoperations, and complication rates of Cf vs an autologous fat processing system (Rv) that incorporates fat harvesting and processing in a single unit. METHODS: We performed a retrospective cohort study of consecutive patients who underwent autologous fat grafting during reconstructive breast surgery with Rv or Cf...
October 11, 2016: Aesthetic Surgery Journal
Scott L Spear, Courtney N Coles, Braden K Leung, Matthew Gitlin, Mousam Parekh, David Macarios
BACKGROUND: For years, the safety and effectiveness of autologous fat grafting (AFG) for breast reconstruction have been in question, with particular concern over fat necrosis, calcifications, cyst formation, and interfering with the detection of breast cancer. However, increasing evidence suggests that the complication rates and clinical results are generally acceptable to both clinicians and patients. The emerging challenge is the numerous AFG techniques and systems, where there are limited knowledge and data...
August 2016: Plastic and Reconstructive Surgery. Global Open
Alisson Macário de Oliveira, Matheus Ferreira do Nascimento, Magda Rhayanny Assunção Ferreira, Danielle Feijó de Moura, Talita Giselly Dos Santos Souza, Gabriela Cavalcante da Silva, Eduardo Henrique da Silva Ramos, Patrícia Maria Guedes Paiva, Paloma Lys de Medeiros, Teresinha Gonçalves da Silva, Luiz Alberto Lira Soares, Cristiano Aparecido Chagas, Ivone Antônia de Souza, Thiago Henrique Napoleão
ETHNOPHARMACOLOGICAL RELEVANCE: Morus alba L. (white mulberry) is used in traditional medicine worldwide, including Brazil. The leaves of this plant are used to treat inflammatory disorders. Universal interest in this plant necessitates studies on the toxicological safety and scientific substantiation of the medicinal properties of M. alba. In previous work, we investigated the acute toxicity of orally administered M. alba ethanol extract in mice. AIM OF THE STUDY: This work was designed to investigate the ethanol extract obtained from M...
September 2, 2016: Journal of Ethnopharmacology
Sungjin A Song, Edward T Chang, Victor Certal, Michael Del Do, Soroush Zaghi, Stanley Yung Liu, Robson Capasso, Macario Camacho
OBJECTIVE: To perform a systematic review and meta-analysis for studies evaluating genioplasty alone, genial tubercle advancement (GTA) alone, and GTA with hyoid surgery (GTA-HS) to treat obstructive sleep apnea (OSA). DATA SOURCES: Ten databases. REVIEW METHODS: Three authors searched through November 15, 2015. RESULTS: 1,207 studies were screened; 69 were downloaded; and 13 studies met inclusion criteria. A total of 111 patients were included, with 27 standard genioplasty, 10 modified genioplasty, 24 GTA, and 50 GTA-HS patients...
August 22, 2016: Laryngoscope
Inês Correia, Inês Brás Marques, Mário Sousa, Sónia Batista, Rogério Ferreira, Carla Nunes, Carmo Macário, Luís Cunha, Lívia Sousa
Treatment persistence in first-line injectable disease-modifying therapies (DMT) for relapsing-remitting multiple sclerosis (RRMS) is an important indicator of effectiveness. Identifying predictors of treatment discontinuation is important as there are other therapies currently available and a growing range of emerging drugs. We report a retrospective study of RRMS and clinically isolated syndrome patients followed in a University Hospital during a 13-year period with the objective of identifying predictors of treatment persistence...
November 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Francesca Rappa, Alessandro Pitruzzella, Antonella Marino Gammazza, Rosario Barone, Emanuele Mocciaro, Giovanni Tomasello, Francesco Carini, Felicia Farina, Giovanni Zummo, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello
Large bowel carcinogenesis involves accumulation of genetic alterations leading to transformation of normal mucosa into dysplasia and, lastly, adenocarcinoma. It is pertinent to elucidate the molecular changes occurring in the pre-neoplastic lesions to facilitate early diagnosis and treatment. Heat shock proteins (Hsps), many of which are molecular chaperones, are implicated in carcinogenesis, and their variations with tumor progression encourage their study as biomarkers. There are many reports on Hsps and cancer but none to our knowledge on their systematic quantification in pre-neoplastic lesions of the large bowel...
September 2016: Cell Stress & Chaperones
Ana M Novo, Sonia Batista, Joana Tenente, Carla Nunes, Carmo Macário, Lívia Sousa, Freire Gonçalves
Apathy has been recognized as a frequent symptom in multiple sclerosis (MS) but uncertainty remains about its prevalence and clinical correlates. Therefore, the objective of this work was to assess the prevalence of apathy in patients with MS and to identify clinical and demographic correlates. A case-control study with 30 patients and 30 healthy controls matched for age, gender and education was performed. Apathy diagnosis was established using Robert et al.'s criteria. Additionally, apathy was assessed using the 10-item short version of the clinical-rated Apathy Evaluation Scale (AES-C-10)...
November 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Mariana Samôr Lopes, Thayse Cristina Pereira Bertucci, Luciano Rapagnã, Rafael de Almeida Tubino, Cassiano Monteiro-Neto, Acácio Ribeiro Gomes Tomas, Maria Cristina Tenório, Tânia Lima, Rosa Souza, Jorge Domingo Carrillo-Briceño, Manuel Haimovici, Kita Macario, Carla Carvalho, Orangel Aguilera Socorro
Brazilian shellmounds are archaeological sites with a high concentration of marine faunal remains. There are more than 2000 sites along the coast of Brazil that range in age from 8,720 to 985 cal BP. Here, we studied the ichthyoarchaeological remains (i.e., cranial/postcranial bones, otoliths, and teeth, among others) at 13 shellmounds on the southern coast of the state of Rio de Janeiro, which are located in coastal landscapes, including a sandy plain with coastal lagoons, rocky islands, islets and rocky bays...
2016: PloS One
Macario Camacho, Soroush Zaghi, Victor Certal, Jose Abdullatif, Rahul Modi, Shankar Sridhara, Anthony M Tolisano, Edward T Chang, Benjamin B Cable, Robson Capasso
UNLABELLED: Objective. To evaluate the association between nasal obstruction and (1) demographic factors, (2) medical history, (3) physical tests, and (4) nasal exam findings. Study Design. CASE SERIES: Methods. Chart review at a tertiary medical center. Results. Two hundred-forty consecutive patients (52.1 ± 17.5 years old, with a Nasal Obstruction Symptom Evaluation (NOSE) score of 32.0 ± 24.1) were included. Demographic factors and inferior turbinate sizes were not associated with NOSE score or Nasal Obstruction Visual Analog Scale (NO-VAS)...
2016: Plastic Surgery International
Keith Volner, Brandyn Dunn, Edward T Chang, Sungjin A Song, Stanley Yung-Chuan Liu, Scott E Brietzke, Peter O'Connor, Macario Camacho
The objective is to determine if apnea-hypopnea index (AHI) and lowest oxygen saturation (LSAT) improve after transpalatal advancement pharyngoplasty (TPAP) with obstructive sleep apnea (OSA) in adults, using a systematic review and meta-analysis. Nine databases, including PubMed/MEDLINE, were searched through April 1, 2016. All studies that included patients who underwent TPAP alone were included in this analysis. Fifty-six studies were potentially relevant, 37 were downloaded and five studies met criteria with 199 patients (age: 42...
June 11, 2016: European Archives of Oto-rhino-laryngology
Simona Frigerio, Marina Macario, Giuliano Iacovone, Kodjo J Dussey-Comlavi, Paolo Narcisi, Amadou T Ndiaye, Stefania Moramarco, Rosaria Alvaro, Leonardo Palombi, Ersilia Buonomo
BACKGROUND: The aim of this study was to investigate the occurrence of urinary schistosomiasis in school children in a rural village of Northern Senegal, and to evaluate the impact of this parasitic infection on children's health, growth, and nutritional status. METHODS: A cross-sectional survey was carried out on 465 children resident in the village of Kassak Nord, in Senegal, in an area which is highly endemic for Schistosoma haematobium. Data on health, nutritional status and urinary schistosomiasis were collected...
August 2016: Minerva Pediatrica
Anneke Kramer, Maria Pippias, Vianda S Stel, Marjolein Bonthuis, José Maria Abad Diez, Nikolaos Afentakis, Ramón Alonso de la Torre, Patrice Ambuhl, Boris Bikbov, Encarnación Bouzas Caamaño, Ivan Bubic, Jadranka Buturovic-Ponikvar, Fergus J Caskey, Pablo Castro de la Nuez, Harijs Cernevskis, Frederic Collart, Jordi Comas Farnés, Maria de Los Ángeles Garcia Bazaga, Johan De Meester, Manuel Ferrer Alamar, Patrik Finne, Liliana Garneata, Eliezer Golan, James G Heaf, Marc Hemmelder, Kyriakos Ioannou, Nino Kantaria, Mykola Kolesnyk, Reinhard Kramar, Mathilde Lassalle, Visnja Lezaic, Frantisek Lopot, Fernando Macário, Angela Magaz, Eduardo Martín-Escobar, Wendy Metcalfe, Mai Ots-Rosenberg, Runolfur Palsson, Celestino Piñera Celestino, Halima Resić, Boleslaw Rutkowski, Carmen Santiuste de Pablos, Viera Spustová, Maria Stendahl, Ariana Strakosha, Gültekin Süleymanlar, Marta Torres Guinea, Anna Varberg Reisæter, Evgueniy Vazelov, Edita Ziginskiene, Ziad A Massy, Christoph Wanner, Kitty J Jager, Marlies Noordzij
BACKGROUND: This article provides a summary of the 2013 European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report (available at, with a focus on patients with diabetes mellitus (DM) as the cause of end-stage renal disease (ESRD). METHODS: In 2015, the ERA-EDTA Registry received data on renal replacement therapy (RRT) for ESRD from 49 national or regional renal registries in 34 countries in Europe and bordering the Mediterranean Sea...
June 2016: Clinical Kidney Journal
Kita D Macario, Eduardo Q Alves, Carla Carvalho, Fabiana M Oliveira, Christopher Bronk Ramsey, David Chivall, Rosa Souza, Luiz Ricardo L Simone, Daniel C Cavallari
In Brazilian archaeological shellmounds, many species of land snails are found abundantly distributed throughout the occupational layers, forming a contextualized set of samples within the sites and offering a potential alternative to the use of charcoal for radiocarbon dating analyses. In order to confirm the effectiveness of this alternative, one needs to prove that the mollusk shells reflect the atmospheric carbon isotopic concentration in the same way charcoal does. In this study, 18 terrestrial mollusk shells with known collection dates from 1948 to 2004 AD, around the nuclear bombs period, were radiocarbon dated...
2016: Scientific Reports
Matias Vested Madsen, Alex Macario, Satoshi Yamamoto, Pedro Tanaka
In this study, we examined the regularly scheduled, formal teaching sessions in a single anesthesiology residency program to (1) map the most common primary instructional methods, (2) map the use of 10 known teaching techniques, and (3) assess if residents scored sessions that incorporated active learning as higher quality than sessions with little or no verbal interaction between teacher and learner. A modified Delphi process was used to identify useful teaching techniques. A representative sample of each of the formal teaching session types was mapped, and residents anonymously completed a 5-question written survey rating the session...
June 1, 2016: A & A Case Reports
Leh-Kiong Huon, Stanley Yung-Chuan Liu, Macario Camacho, Christian Guilleminault
PURPOSE: The purpose of this study was to evaluate the association between obstructive sleep apnea (OSA) and ophthalmologic diseases, specifically glaucoma, nonarteritic anterior ischemic optic neuropathy (NAION), retinal vein occlusion (RVO), central serous chorioretinopathy (CSR), and floppy eyelid syndrome (FES), by performing a systematic review and meta-analysis of published studies. METHODS: PubMed, Embase, and Scopus databases were searched for observational studies on OSA and its association with select ophthalmologic diseases...
May 26, 2016: Sleep & Breathing, Schlaf & Atmung
Antonella Marino Gammazza, Celeste Caruso Bavisotto, Rosario Barone, Everly Conway de Macario, Alberto J L Macario
BACKGROUND: Alzheimer's disease (AD) is a dementia, a neurodegenerative condition, and a protein-misfolding disease or proteinopathy, characterized by protein deposits, extracellular plaques and intracellular neurofibrillary tangles, which contain the AD's typical pathological proteins, abnormal β-amyloid and hyperphosphorylated tau, respectively, and are located predominantly in the cortex of the frontal, parietal, and temporal brain lobes. What is the role of molecular chaperones in AD? Data indicate that molecular chaperones, also known as Hsp, are involved in AD, probably displaying protective roles and/or acting as pathogenic factors as it occurs in chaperonopathies in which case AD would be suitable to chaperonotherapy...
2016: Current Pharmaceutical Design
Macario Camacho, Sungjin A Song, Anthony M Tolisano
No abstract text is available yet for this article.
May 2016: Cranio: the Journal of Craniomandibular Practice
Rubiceli Medina-Aguilar, Laurence A Marchat, Elena Arechaga Ocampo, Patricio Gariglio, Jaime García Mena, Nicolás Villegas Sepúlveda, Macario Martínez Castillo, César López-Camarillo
The Aurora protein kinase (AURKA) and the Polo-like kinase-1 (PLK1) activate the cell cycle, and they are considered promising druggable targets in cancer therapy. However, resistance to chemotherapy and to specific small‑molecule inhibitors is common in cancer patients; thus alternative therapeutic approaches are needed to overcome clinical resistance. Here, we showed that the dietary compound resveratrol suppressed the cell cycle by targeting AURKA and PLK1 kinases. First, we identified genes modulated by resveratrol using a genome-wide analysis of gene expression in MDA-MB-231 breast cancer cells...
June 2016: Oncology Reports
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"