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https://www.readbyqxmd.com/read/28514326/cancellation-of-elective-cases-in-a-recently-opened-tertiary-quaternary-level-hospital-in-the-middle-east
#1
Amanda J Morris, James McAvoy, Dana Dweik, Massimo Ferrigno, Alex Macario, Markus Haisjackl
Case cancellations have a negative financial impact due to revenue loss and the potential costs of underutilized time. The goals of this study at a recently opened hospital in the Middle East were to measure the cancellation rates for elective surgical or endoscopic cases and to identify the reasons for cancellation. During the 1-month study period, 170 (22.4%) of the 760 scheduled cases were cancelled. Cultural norms and patient no-shows on the day of surgery accounted for the majority of case cancellations...
May 12, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28498266/use-of-positive-airway-pressure-following-middle-ear-surgery-a-practice-survey-of-otologists
#2
Douglas S Ruhl, Anthony M Tolisano, Bradley W Kesser, George T Hashisaki, Macario Camacho
BACKGROUND: Positive airway pressure (PAP) devices are used as treatment for obstructive sleep apnea (OSA). PAP may increase middle ear pressure which is of interest to otologic surgeons. There is a lack of data to guide management of PAP therapy after middle ear surgery. OBJECTIVE: To elucidate how otologic surgeons manage PAP in their patients after ear surgery. STUDY DESIGN: A survey e-mailed to practicing members of the American Neurotology Society...
May 11, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28488882/development-of-bioanalytical-assays-for-variegin-a-peptide-based-bivalent-direct-thrombin-inhibitor
#3
Norrapat Shih, Leonardo Pinto de Carvalho, Yie Hou Lee, Mauricio Macario Rocha, Adriano Henrique Pereira Barbosa, José Marconi A de Sousa, Antonio Carlos de C Carvalho, R Manjunatha Kini, Mark Y Chan
AIM: Variegin is an anticoagulant peptide that will be tested in porcine models of percutaneous coronary intervention. We developed three bioanalytical assays for variegin quantitation and utilized these methods to evaluate pharmacokinetics of variegin in pigs. Results & methodology: The LC-MS/MS, thrombin amidolytic and modified thrombin time assays had a quantitation range of 21.6-5541.7, 10.8-5541.7 and 5.4-5541.7 nM in human plasma, respectively. The elimination half-lives obtained using the LC-MS/MS, modified thrombin time and thrombin amidolytic assays were 52...
May 10, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28457424/what-can-we-do-when-all-collapses-fatal-outcome-of-collapsing-glomerulopathy-and-systemic-lupus-erythematosus-with-diffuse-alveolar-hemorrhage-case-report
#4
H Pinto, R Leal, L Rodrigues, L Santos, C Romãozinho, F Macário, R Alves, J Pratas, V Sousa, C Marinho, L Prado E Castro, F Costa, M Campos, A Mota, A Figueiredo
INTRODUCTION: Collapsing glomerulopathy (CG) is a rare form of glomerular injury. Although commonly associated with human immunodeficiency virus (HIV) infection, it can occur in association with systemic lupus erythematosus (SLE). CASE REPORT: We present the case of a 50-year-old man, with chronic kidney disease secondary to focal and segmental glomerulosclerosis, who received a cadaveric kidney transplant in 2007. There were no relevant intercurrences until May 2015, when he presented with nephrotic range proteinuria (± 4 g/d)...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457403/surgical-complications-in-early-post-transplant-kidney-recipients
#5
H Pinto, R Leal, L Rodrigues, L Santos, C Romãozinho, F Macário, R Alves, C Bastos, A Roseiro, F Costa, M Campos, A Mota, A Figueiredo
BACKGROUND: The purpose of this study was to determine the incidence of early surgical complications of kidney transplantation in our institution and its association with donor and recipient factors, as well as patient and transplant outcome. METHODS: A retrospective cohort study of all kidney transplants performed during 2015 was made. We evaluated the incidence of surgical complications and the outcome of patients and grafts at a 3-month follow-up interval. RESULTS: During the study period, 141 kidney transplants occurred...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457399/polyomavirus-nephropathy-ten-year-experience
#6
J S Costa, E Ferreira, R Leal, N Bota, C Romãozinho, V Sousa, C Marinho, L Santos, F Macário, R Alves, J Pratas, M Campos, A Figueiredo
BACKGROUND: Polyomavirus nephropathy (BKVN) is an important cause of chronic allograft dysfunction (CAD). Recipient determinants (male sex, white race, and older age), deceased donation, high-dose immunosuppression, diabetes, delayed graft function (DGF), cytomegalovirus infection, and acute rejection (AR) are risk factors. Reducing immunosuppression is the best strategy in BKVN. The objective of our study was to evaluate CAD progression after therapeutic strategies in BKVN and risk factors for graft loss (GL)...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457396/nephrotic-range-proteinuria-in-renal-transplantation-clinical-and-histologic-correlates-in-a-10-year-retrospective-study
#7
R Leal, H Pinto, A Galvão, L Santos, C Romãozinho, F Macário, R Alves, J Pratas, V Sousa, C Marinho, L Prado E Castro, M Campos, A Mota, A Figueiredo
INTRODUCTION: There is a high incidence of nephrotic proteinuria in renal transplant recipients, which is an accurate predictor of graft loss. Despite this, its histologic correlates and prognostic implications are still not well characterized. We assessed the clinical and histological correlates of kidney transplantation patients with nephrotic range proteinuria. METHODS: We have retrospectively analyzed clinical and histological data from 50 kidney transplantation biopsy specimens from 44 renal transplant recipients with nephrotic range proteinuria between 2006 and 2015...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457395/fibrogenesis-in-kidney-transplant-dysfunction-progress-biomarkers
#8
J S Costa, R Alves, V Sousa, C Marinho, C Romãozinho, L Santos, F Macário, J Pratas, L Prado E Castro, M Campos, A Figueiredo
INTRODUCTION: Fibrogenesis markers, such as alpha-actin (AA), CD163 (macrophages), and E-cadherin, have been studied as chronic kidney allograft injury (CAI) predictors, a major cause of allograft failure. OBJECTIVE: Investigate the value of these markers in predicting CAI and initiation of dialysis. MATERIALS AND METHODS: Retrospective analysis of 26 kidney allograft biopsies (from 22 patients with CAI) during 2 years, evaluating intensity and percentage of marked cells on glomeruli and tubulointerstitial compartment...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457394/early-rehospitalization-post-kidney-transplant-due-to-infectious-complications-can-we-predict-the-patients-at-risk
#9
R Leal, H Pinto, A Galvão, L Rodrigues, L Santos, C Romãozinho, F Macário, R Alves, M Campos, A Mota, A Figueiredo
INTRODUCTION: Rehospitalization early post-kidney transplant is common and has a negative impact in morbidity, graft survival, and health costs. Infection is one the most common causes, and identifying the risk factors for early readmission due to infectious complications may guide a preventive program and improve outcome. The aim of this study was to evaluate the incidence, characterize the population, and identify the risk factors associated with early readmission for infectious complications post-kidney transplantation...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457392/long-term-outcomes-of-kidney-transplantation-from-expanded-criteria-deceased-donors-a-single-center-experience
#10
E Ferreira, J Costa, C Romãozinho, L Santos, F Macário, C Bastos, R Alves, A Figueiredo
BACKGROUND: Organ shortage has prompted the use of expanded-criteria donors (ECDs). Our objective was to compare long-term outcomes of kidney transplants from ECDs with those from concurrent standard-criteria donors (SCDs). In addition, we evaluated variables associated with graft survival in both groups. METHODS: We retrospectively reviewed all 617 deceased-donor kidney transplantations performed from 2005 to 2009 in our department. The population was divided according to donor status into ECD or SCD...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28392099/cerebrovascular-dissemination-in-time-and-space-as-a-predictor-of-cardioembolism
#11
João André Sousa, Mafalda Mendes-Pinto, João Sargento-Freitas, Fernando Silva, Carla Cecília, Carmo Macário, Ana Gouveia, Cristina Machado, Bruno Rodrigues, Gustavo C Santo, Ana Lima, Ricardo Veiga, Luís Cunha, António Freire-Gonçalves
BACKGROUND: Cardioembolism has tendency to recur and cause lesions in distinct cerebrovascular territories. Using the imaging characteristics of cerebral lesions to determine dissemination in time and space (DTS) is a concept already used in other neurologic conditions; however, it has never been applied as a diagnostic tool in ischemic stroke etiology. AIM: This study aimed to assess DTS as a diagnostic marker of cardioembolism. METHODS: We enrolled consecutive patients with acute ischemic stroke of various etiologies admitted in a cerebrovascular disease nursery from a university hospital in a retrospective cohort study...
April 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28378061/tongue-surgeries-for-pediatric-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#12
REVIEW
Macario Camacho, Michael W Noller, Soroush Zaghi, Lauren K Reckley, Camilo Fernandez-Salvador, Erika Ho, Brandyn Dunn, Dylan Chan
OBJECTIVES: To evaluate the international literature for studies reporting outcomes for obstructive sleep apnea (OSA) in children undergoing isolated tongue surgeries. METHODS: Two authors searched from inception through November 14, 2016 in four databases including PubMed/MEDLINE. RESULTS: 351 studies were screened. Eleven studies (116 children) met criteria. Most children were syndromic and had craniofacial disorders, co-morbidities, or other serious medical issues...
April 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28367396/comparing-anesthesiology-residency-training-structure-and-requirements-in-seven-different-countries-on-three-continents
#13
Satoshi Yamamoto, Pedro Tanaka, Matias V Madsen, Alex Macario
Little has been published comparing the graduate medical education training structure and requirements across multiple countries. The goal of this study was to summarize and compare the characteristics of anesthesiology training programs in the USA, UK, Canada, Japan, Brazil, Denmark, and Switzerland as a way to better understand efforts to train anesthesiologists in different countries. Two physicians trained in each of the seven countries (convenience sample) were interviewed using a semi-structured approach...
February 26, 2017: Curēus
https://www.readbyqxmd.com/read/28343610/what-s-new-in-gold-2017
#14
Patricia Sobradillo Ecenarro, Ciro Casanova Macario
No abstract text is available yet for this article.
March 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28336273/soft-palate-fistula-after-radiofrequency-ablation-for-primary-snoring-a-case-report-and-literature-review
#15
Lauren K Reckley, Camilo Fernandez-Salvador, Edward T Chang, Macario Camacho
No abstract text is available yet for this article.
March 7, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28319457/medical-students-and-staff-physicians-the-question-of-social-media
#16
Michael Noller, Johnny P Mai, Philip E Zapanta, Macario Camacho
Social media's prevalence among the professional world is rapidly increasing. Its use among medical personnel-specifically, medical students, resident physicians, and staff physicians-could compromise personal-professional boundaries. Could the acceptance or lack of acceptance of a friend request bias the medical student application process? If friend requests are accepted, then medical students, resident physicians, and staff physicians are provided access to very personal aspects of one another's lives, which may not have been the intent...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28282574/long-term-effectiveness-and-safety-of-natalizumab-in-a-portuguese-population
#17
I Correia, S Batista, O Galego, I B Marques, J Jesus-Ribeiro, A I Martins, C Nunes, M C Macário, L Cunha, L Sousa
OBJECTIVES: Natalizumab long-term effectiveness data in real-world relapsing-remitting multiple sclerosis (RRMS) is needed. Our objective is to report the long-term effectiveness and safety of natalizumab in a cohort of RRMS patients. METHODS: This is a retrospective study of natalizumab treatment for two years or longer in RRMS. Annualized relapse rate, Expanded Disability Status Scale (EDSS), brain magnetic resonance imaging T2 lesion volume, JC virus antibody status, previous treatments and adverse events were analysed...
March 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28273767/impairment-of-social-cognition-in-multiple-sclerosis-amygdala-atrophy-is-the-main-predictor
#18
Sonia Batista, Otília C d'Almeida, Ana Afonso, Sandra Freitas, Carmo Macário, Lívia Sousa, Miguel Castelo-Branco, Isabel Santana, Luís Cunha
BACKGROUND: Patients with multiple sclerosis (MS) frequently reveal social behavior disturbance. Nevertheless, little is known regarding the impact of MS on social cognition, particularly theory of mind (ToM), and its neural basis. OBJECTIVES: To explore how ToM is affected in MS and its neural correlates. METHODS: Enrolled 60 consecutive MS patients and 60 healthy controls (HC) matched on age, sex, and education. Participants underwent ToM testing (Eyes Test, Videos Test) and 3 T brain magnetic resonance imaging (MRI)...
December 1, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28237516/tongue-retaining-devices-for-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#19
Edward T Chang, Camilo Fernandez-Salvador, Jeremy Giambo, Blaine Nesbitt, Stanley Yung-Chuan Liu, Robson Capasso, Clete A Kushida, Macario Camacho
OBJECTIVE: Tongue Retaining Devices (TRD) anteriorly displace the tongue with suction forces while patients sleep. TRD provide a non-surgical treatment option for patients with Obstructive Sleep Apnea (OSA). Our objective was to conduct a systematic review of the international literature for TRD outcomes as treatment for OSA. METHODS: Three authors independently and systematically searched four databases (including PubMed/MEDLINE) through June 26, 2016. We followed guidelines set within the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)...
January 18, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28212901/the-dissociation-of-the-hsp60-pro-caspase-3-complex-by-bis-pyridyl-oxadiazole-copper-complex-cubipyoxa-leads-to-cell-death-in-nci-h292-cancer-cells
#20
Celeste Caruso Bavisotto, Dragana Nikolic, Antonella Marino Gammazza, Rosario Barone, Filippa Lo Cascio, Emanuele Mocciaro, Giovanni Zummo, Everly Conway de Macario, Alberto Jl Macario, Francesco Cappello, Valentina Giacalone, Andrea Pace, Giampaolo Barone, Antonio Palumbo Piccionello, Claudia Campanella
Cell survival and proliferation are central to carcinogenesis, involving various mechanisms among which those that impede apoptosis are important. In this, the role of the molecular chaperone Hsp60 is unclear since it has been reported that it can be both, pro- or anti-apoptotic. A solution to this riddle is crucial to the development of anti-cancer therapies targeting Hsp60. We addressed this question using a tumor cell line, NCI-H292, and [Cu(3,5-bis(2'-pyridyl)-1,2,4-oxadiazole)2(H2O)2](ClO4)2, CubipyOXA, a copper-containing compound with cytotoxic properties...
May 2017: Journal of Inorganic Biochemistry
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