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Atrial fibrosis

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https://www.readbyqxmd.com/read/29444259/atrial-fibrosis-associated-with-left-ventricular-apical-hypoplasia
#1
Peng-Fei Chen, Ran Peng, Liang Tang, Xin-Qun Hu
No abstract text is available yet for this article.
February 12, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29433967/role-of-myocardial-collagen-degradation-and-fibrosis-in-right-ventricle-dysfunction-in-transposition-of-the-great-arteries-after-atrial-switch
#2
Magalie Ladouceur, Stephanie Baron, Valérie Nivet-Antoine, Gérard Maruani, Gilles Soulat, Helena Pereira, Anne Blanchard, Pierre Boutouyrie, Jean Louis Paul, Elie Mousseaux
BACKGROUND: Heart failure is a serious event in patients with transposition of the great arteries (D-TGA) after atrial redirection surgery. We aimed to determine the association between myocardial fibrosis and systolic and diastolic systemic right ventricle (sRV) dysfunction. METHODS: Diastolic and systolic function of sRV was prospectively assessed using echocardiography and cardiac magnetic resonance imaging (CMR) in 48 patients with atrially switched D-TGA and 26 healthy subjects...
January 31, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29433438/protective-effect-of-hydrogen-rich-saline-on-pressure-overload-induced-cardiac-hypertrophyin-rats-possible-role-of-jak-stat-signaling
#3
Zhixin Fan, Yufei Gao, Zhiwei Huang, Fenghua Xue, Shujing Wu, Jing Yang, Liqun Zhu, Lu Fu
BACKGROUND: Molecular hydrogen has been shown to have antioxidant effect and have been used to prevent oxidative stress-related diseases. The goal of this study was to explore if hydrogen-rich saline (HRS) plays a cardioprotective effect on abdominal aortic constriction (AAC) induced cardiac hypertrophy in rats. 60adult Sprague-Dawley rats received surgically the AAC for 6-week. After the surgery, the rats were randomly divided into 4 groups (15 for each):1: sham-operated (sham); 2: AAC-model; 3: AAC + Low HRS (LHRS); and 4: AAC + High HRS (HHRS)...
February 13, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29428663/shengmai-san-derived-herbal-prevents-the-development-of-a-vulnerable-substrate-for-atrial-fibrillation-in-a-rat-model-of-ischemic-heart-failure
#4
Jin Ma, Shiyu Ma, Chunxia Yin, Huanlin Wu
OBJECTIVE: The study aimed to investigate whether a Shengmai San-derived herbal, Fumai granule (FM), which had a preventive effect on atrial fibrillation (AF) in myocardial infarction (MI)-induced heart failure (HF) rat and to determine the underlying mechanisms. DESIGN AND METHODS: MI was induced by a ligation of the left anterior descending coronary artery. One week after MI surgery, FM was gavaged for 4 weeks. AF inducibility was detected by transesophageal programmed electrical stimulation technology...
February 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29428236/liver-fibrosis-marker-7s-domain-of-collagen-type-iv-in-patients-with-pre-capillary-pulmonary-hypertension
#5
Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Yu Sato, Shunsuke Watanabe, Yuki Kanno, Satoshi Abe, Makiko Miyata-Tatsumi, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: Pulmonary hypertension (PH) causes right ventricular dysfunction and central venous congestion, and may lead to congestive hepatopathy. The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease. We aimed to determine whether P4NP 7S is related to hemodynamic parameters, and assessed the potential values of P4NP 7S to predict mortality. METHODS: Consecutive 76 pre-capillary PH patients were divided into tertiles based on their serum P4NP 7S levels...
February 7, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29424013/cigarette-smoking-causes-a-worse-long-term-outcome-in-persistent-atrial-fibrillation-following-catheter-ablation
#6
Wen-Han Cheng, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Yuan Hung, Fa-Po Chung, Ting-Yung Chang, Ting-Chung Huang, Shinya Yamada, Simon Salim, Abigail Louise D Te, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Tseng-Ying Tsai, Shin-Huei Liu, Shih-Ann Chen
INTRODUCTION: Cigarette smoking contributes to the development of atrial fibrosis via nicotine. The impact of smoking on ablation results in persistent atrial fibrillation (AF) is unknown. We aimed to investigate the triggers and long-term outcome between smokers and non-smokers in the patients with persistent AF after catheter ablation. METHODS: This study included 201 (177 males, 53±10 years old) patients who received index catheter ablation, including pulmonary vein isolation (PVI) and complex fractionated atrial electrograms (CFAEs) ablation for persistent AF, retrospectively...
February 9, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29420707/association-of-left-ventricular-late-gadolinium-enhancement-with-left-atrial-low-voltage-areas-in-patients-with-atrial-fibrillation
#7
Clara Stegmann, Cosima Jahnke, Ingo Paetsch, Sebastian Hilbert, Arash Arya, Andreas Bollmann, Gerhard Hindricks, Philipp Sommer
Aims: Presence of late gadolinium enhancement (LGE) is related to adverse cardiovascular outcome. Many patients suffering from atrial fibrillation (AF) undergo cardiovascular magnetic resonance (CMR) imaging prior to ablation. Since quantification of atrial fibrosis still lacks reproducibility, we sought to investigate risk factors for the presence of left ventricular (LV)-LGE and a possible correlation between ventricular fibrosis as defined by positive LGE and pathological atrial voltage maps evaluated by 3D mapping systems...
February 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29414527/echocardiographic-risk-markers-of-sudden-death-in-patients-with-temporal-lobe-epilepsy
#8
Guilherme L Fialho, Arthur G Pagani, Peter Wolf, Roger Walz, Katia Lin
Patients with epilepsy (PWE) have an increased risk for sudden unexpected death compared to the general population. Echocardiography can analyze structural and functional heart changes that have impact on outcomes, including sudden cardiac and all-cause death. Our hypothesis is that subtle heart abnormalities occur in PWE. Thirty patients with temporal lobe epilepsy without any known cardiovascular disease, followed for at least 1 year, were enrolled between July 2015 and July 2016 and submitted to a 12-lead electrocardiogram, treadmill test and transthoracic echocardiogram...
February 2, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29411287/mechanisms-of-atrial-fibrillation-in-athletes-what-we-know-and-what-we-do-not-know
#9
REVIEW
E Guasch, L Mont, M Sitges
Exercise is an emerging cause of atrial fibrillation (AF) in young individuals without coexisting cardiovascular risk factors. The causes of exercise-induced atrial fibrillation remain largely unknown, and conclusions are jeopardised by apparently conflicting data. Some components of the athlete's heart are known to be arrhythmogenic in other settings. Bradycardia, atrial dilatation and, possibly, atrial premature beats are therefore biologically plausible contributors to exercise-induced AF. Challenging findings in an animal model suggest that exercise might also prompt the development of atrial fibrosis, possibly due to cumulative minor structural damage after each exercise bout...
February 6, 2018: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29404472/clinical-burden-of-liver-disease-from-hemochromatosis-at-an-academic-medical-center
#10
Sergio A Sánchez-Luna, Kyle E Brown
Hereditary hemochromatosis (HH) can cause cirrhosis and hepatocellular carcinoma (HCC), but the frequency of these complications is controversial. To address this question, we reviewed the experience with HH at an academic medical center that is the sole liver transplantation center in a state with a population that is >90% Caucasian. The records of all subjects with International Classification of Diseases, Ninth Revision, code 275, "disorders of iron metabolism" seen at the University of Iowa Hospitals and Clinics between January 1, 2004 and December 31, 2014 were reviewed, and HFE C282Y homozygotes and C282Y/H63D compound heterozygotes were identified...
July 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29402528/influence-of-chronic-volume-overload-induced-atrial-remodeling-on-electrophysiological-responses-to-cholinergic-receptor-stimulation-in-the-isolated-rat-atria
#11
Xin Cao, Megumi Aimoto, Marie Fukumoto, Yoshinobu Nagasawa, Hikaru Tanaka, Akira Takahara
Whereas molecular mechanisms of atrial fibrillation (AF) have been widely investigated, there is limited information regarding interrelation between chronic volume overload and parasympathetic nervous system in the pathophysiology of AF. In this study, we investigated the influence of abdominal aorto-venocaval shunt (AVS)-induced atrial remodeling on electrophysiological responses to cholinergic receptor stimulation in the isolated rat atria. Interstitial fibrosis, cardiomyocyte hypertrophy and atrial enlargement, known as structural arrhythmogenic substrates for AF, took place after one month of AVS operation...
January 16, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29392412/cardiac-fibroblasts-active-players-in-atrial-electrophysiology
#12
REVIEW
Alexander Klesen, Dorothee Jakob, Ramona Emig, Peter Kohl, Ursula Ravens, Rémi Peyronnet
Fibrotic areas in cardiac muscle-be it in ventricular or atrial tissue-are considered as obstacles for conduction of the excitatory wave and can therefore facilitate re-entry, which may contribute to the sustenance of cardiac arrhythmias. Persistence of one of the most frequent arrhythmias, atrial fibrillation (AF), is accompanied by enhanced atrial fibrosis. Any kind of myocardial perturbation, whether via mechanical stress or ischemic damage, inflammation, or irregular and high-frequency electrical activity, activates fibroblasts...
February 1, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29390467/role-of-serum-tgf-%C3%AE-1-level-in-atrial-fibrosis-and-outcome-after-catheter-ablation-for-paroxysmal-atrial-fibrillation
#13
Ye Tian, Yubin Wang, Weijie Chen, Yuehui Yin, Mu Qin
This study aimed to evaluate the relationship between serum transforming growth factor-β1 (TGF-β1) concentration and atrial fibrosis and to determine whether plasma TGF-β1 concentration is an independent predictor of atrial fibrillation (AF) recurrence after catheter ablation.We included 98 consecutive patients who underwent catheter ablation, including 38 with paroxysmal AF (AF group) and 60 with paroxysmal supraventricular tachycardia (control group). We compared their preablation serum concentration of biomarkers and clinical and echocardiographic findings...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381383/atrial-fibrillation-and-its-complications-in-arterial-hypertension-the-potential-preventive-role-of-%C3%AF-3-polyunsaturated-fatty-acids
#14
GianLuca Colussi, Cristiana Catena, Valentina Fagotto, Daniele Darsiè, Gabriele Brosolo, Nicole Bertin, Leonardo A Sechi
Atrial fibrillation (AF) is the most common type of arrhythmia in the general population with a prevalence that reaches one third of patients with arterial hypertension. Several risk factors frequently associated with hypertension predispose the myocardium to AF by inducing atrial inflammation and fibrosis and altering atrial electrical and mechanical characteristics. AF influences the quality of life of hypertensive patients since it increases incidence of stroke and other thromboembolic events, and mortality...
January 30, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29380561/doxycycline-attenuates-chronic-intermittent-hypoxia-induced-atrial-fibrosis-in-rats
#15
Weiding Wang, Kai Zhang, Xiongfeng Li, Zuowang Ma, Yue Zhang, Meng Yuan, Ya Suo, Xue Liang, Gary Tse, Christos A Goudis, Tong Liu, Guangping Li
INTRODUCTION: Atrial structural remodeling in the form of fibrosis contributes to the arrhythmic substrate in atrial fibrillation (AF). The aim of this study was to investigate the effects of doxycycline on chronic intermittent hypoxia (CIH)-induced atrial fibrosis and the pathophysiological mechanisms underlying such changes. METHODS: A total of 30 Sprague-Dawley rats were randomized into three groups: Control group, CIH group, CIH with doxycycline treatment (CIH-D) group...
January 29, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29378301/connexin43-and-zonula-occludens-1-are-targets-of-akt-in-cardiomyocytes-that-correlate-with-cardiac-contractile-dysfunction-in-akt-deficient-hearts
#16
Sangmi Ock, Wang Soo Lee, Hyun Min Kim, Kyu-Sang Park, Young-Kook Kim, Hyun Kook, Woo Jin Park, Tae Jin Lee, E D Abel, Jaetaek Kim
While deletion of Akt1 results in a smaller heart size and Akt2-/- mice are mildly insulin resistant, Akt1-/-/Akt2-/- mice exhibit perinatal lethality, indicating a large degree of functional overlap between the isoforms of the serine/threonine kinase Akt. The present study aimed to determine the cooperative contribution of Akt1 and Akt2 on the structure and contractile function of adult hearts. To generate an inducible, cardiomyocyte-restricted Akt2 knockout (KO) model, Akt2flox/flox mice were crossed with tamoxifen-inducible MerCreMer transgenic (MCM) mice and germline Akt1-/- mice to generate the following genotypes:Akt1+/+; Akt2flox/flox (WT), Akt2flox/flox; α-MHC-MCM (iAkt2 KO), Akt1-/-, and Akt1-/-; Akt2flox/flox; α-MHC-MCM mice (Akt1-/-/iAkt2 KO)...
January 31, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29377366/matrine-reduces-susceptibility-to-post-infarct-atrial-fibrillation-in-rats-due-to-anti-fibrotic-properties
#17
Jin Ma, Shiyu Ma, Chunxia Yin, Huanlin Wu
This study aimed to investigate whether matrine could prevent atrial fibrillation (AF) after myocardial infarction by reducing left atrial fibrosis, and to determine the underlying mechanisms in isolated cardiac fibroblasts (CFs). Five weeks after MI, matrine treated rats had lower rates of AF inducibility and shorter AF duration than MI rats. Matrine improved the left atrial conduction velocity and homogeneity. Matrine decreased the fibrosis positive areas and the protein levels of type I collagen and type III collagen in the left atrium...
January 29, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29375676/fibroblast-growth-factor-21-inhibition-aggravates-cardiac-dysfunction-in-diabetic-cardiomyopathy-by-improving-lipid-accumulation
#18
Cui Chen, Zheying Meng, Yuanyi Zheng, Bing Hu, E Shen
Diabetic cardiomyopathy (DCM) is one of the major causes of morbidity and mortality in diabetic patients. Recent studies have demonstrated an increased level of fibroblast growth factor 21 (FGF21) in the plasma of DCM patients, and FGF21 has been proven to be a cardiovascular protector of the heart. The present study aimed to further investigate the pathogenic role of FGF21 in DCM, hypothesizing that a lack of FGF21 may promote the progression of DCM by regulating the lipid metabolism, cardiac hypertrophy and cardiac fibrosis, thus deteriorating the cardiac dysfunction...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29371431/patients-with-undetermined-stroke-have-increased-atrial-fibrosis-a-cardiac-magnetic-resonance-imaging-study
#19
Ana Catarina Fonseca, Pedro Alves, Nuno Inácio, João Pedro Marto, Miguel Viana-Baptista, Teresa Pinho-E-Melo, José M Ferro, Ana G Almeida
BACKGROUND AND PURPOSE: Some patients with ischemic strokes that are currently classified as having an undetermined cause may have structural or functional changes of the left atrium (LA) and left atrial appendage, which increase their risk of thromboembolism. We compared the LA and left atrial appendage of patients with different ischemic stroke causes using cardiac magnetic resonance imaging. METHODS: We prospectively included a consecutive sample of ischemic stroke patients...
January 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29361492/intra-atrial-dyssynchrony-during-sinus-rhythm-predicts-recurrence-after-the-first-catheter-ablation-for-atrial-fibrillation
#20
Luisa Ciuffo, Susumu Tao, Esra Gucuk Ipek, Tarek Zghaib, Muhammad Balouch, Joao A C Lima, Saman Nazarian, David D Spragg, Joseph E Marine, Ronald D Berger, Hugh Calkins, Hiroshi Ashikaga
OBJECTIVES: The purpose of this study was to evaluate the usefulness of intra-atrial dyssynchrony as a marker of underlying left atrial (LA) remodeling to predict recurrence after the first atrial fibrillation (AF) ablation. BACKGROUND: Catheter ablation for AF remains far from curative with relatively high recurrence rates. One of the causes of recurrence is poor patient selection out of a diverse patient population with different degrees of LA remodeling. METHODS: We included 208 patients with a history of AF (59...
January 12, 2018: JACC. Cardiovascular Imaging
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