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https://www.readbyqxmd.com/read/29659090/detection-of-intra-cardiac-thrombi-and-congestive-heart-failure-in-cats-using-computed-tomographic-angiography
#1
Kyle P Vititoe, Ryan C Fries, Stephen Joslyn, Laura E Selmic, Mark Howes, Jordan P Vitt, Robert T O'Brien
Arterial thromboembolism is a life-threatening condition in cats most commonly secondary to cardiac disease. Echocardiography is the reference standard to evaluate for presence of a thrombus. In humans, computed tomographic (CT) angiography is becoming widely used to detect left atrial thrombi precluding the use of sedation. The purpose of this prospective, controlled, methods comparison pilot study was threefold: (1) describe new CT angiography protocol used in awake cats with cardiac disease and congestive heart failure; (2) determine accuracy of continuous and dynamic acquisition CT angiography to identify and characterize cardiac thrombi from spontaneous echocardiographic contrast using transthoracic echocardiography as our reference standard; (3) identify known negative prognostic factors and comorbidities of the thorax that CT angiography may provide that complement or supersede echocardiographic examination...
April 16, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29658562/microrna%C3%A2-34a-mediates-atrial-fibrillation-through-regulation-of-ankyrin%C3%A2-b-expression
#2
Yun Zhu, Zezhou Feng, Wei Cheng, Yingbin Xiao
Atrial fibrillation (AF) has a high prevalence and recurrence rate, and is associated with substantial mortality. However, its underlying mechanisms are not thoroughly understood. Increasing attention has been paid to the roles of microRNAs (miRs) in the pathogenesis of cardiovascular disease, including miR‑1 and miR‑133 (in the electrophysiological response), and miR‑34a (in cardiac fibrosis). Recently, Ankyrin‑B (Ank‑B), an adaptor protein, has been demonstrated to be associated with AF. As a predicted target gene of miR‑34a, the present study aimed to investigate if miR‑34a has a role in AF via regulation of Ank‑B expression...
April 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29657146/absence-of-fibrosis-and-inflammation-by-cardiac-magnetic-resonance-imaging-in-rheumatoid-arthritis-patients-with-low-to-moderate-disease-activity
#3
William Bradham, Michelle J Ormseth, Comfort Elumogo, Srikanth Palanisamy, Chia-Ying Liu, Mark A Lawson, Jonathan H Soslow, Nadine Kawel-Boehm, David A Bluemke, C Michael Stein
OBJECTIVE: The prevalence of heart failure is increased 2-fold in patients with rheumatoid arthritis (RA); this is not explained by ischemic heart disease or other risk factors for heart failure. We hypothesized that in patients with RA without known heart disease, cardiac magnetic resonance imaging (cMRI) would detect altered cardiac structure, function, and fibrosis. METHODS: We performed 1.5-T cMRI in 59 patients with RA and 56 controls frequency-matched for age, race, and sex, and compared cMRI indices of structure, function, and fibrosis [late gadolinium enhancement (LGE), native T1 mapping, and extracellular volume (ECV)] using Mann-Whitney U tests and linear regression, adjusting for age, race, and sex...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29623658/atrial-fibrillation-in-patients-with-heart-failure-current-state-and-future-directions
#4
REVIEW
Tuoyo O Mene-Afejuku, Persio D López, Adedoyin Akinlonu, Carissa Dumancas, Ferdinand Visco, Savi Mushiyev, Gerald Pekler
Heart failure affects nearly 26 million people worldwide. Patients with heart failure are frequently affected with atrial fibrillation, and the interrelation between these pathologies is complex. Atrial fibrillation shares the same risk factors as heart failure. Moreover, it is associated with a higher-risk baseline clinical status and higher mortality rates in patients with heart failure. The mechanisms by which atrial fibrillation occurs in a failing heart are incompletely understood, but animal studies suggest they differ from those that occur in a healthy heart...
April 5, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29622585/prevalence-and-progression-of-late-gadolinium-enhancement-in-children-and-adolescents-with-hypertrophic-cardiomyopathy
#5
Anna Axelsson Raja, Hoshang Farhad, Anne Marie Valente, John-Paul Couce, John Lynn Jefferies, Henning Bundgaard, Kenneth Zahka, Harry Lever, Anne M Murphy, Euan Ashley, Sharlene M Day, Mark V Sherrid, Ling Shi, David A Bluemke, Charles E Canter, Steven D Colan, Carolyn Y Ho
Background -Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) is believed to represent dense replacement fibrosis. It is seen in ~60% of adult patients with hypertrophic cardiomyopathy (HCM). However, the prevalence of LGE in children and adolescents with HCM is not well established. Additionally, longitudinal studies describing the development and evolution of LGE in pediatric HCM are lacking. This study assesses the prevalence, progression, and clinical correlations of LGE in children and adolescents with, or genetically predisposed to, HCM...
April 5, 2018: Circulation
https://www.readbyqxmd.com/read/29604289/effect-of-spironolactone-on-myocardial-fibrosis-and-other-clinical-variables-in-patients-with-hypertrophic-cardiomyopathy-a-prospective-randomized-trial
#6
Martin S Maron, Raymond H Chan, Navin Kapur, Iris J Jaffe, Adam P McGraw, Raj Kerur, Barry J Maron, James E Udelson
BACKGROUND: Myocardial fibrosis has proved to be an important marker and determinant in the pathogenesis of hypertrophic cardiomyopathy . In particular, scar formation, if substantial, can promote ventricular tachyarrhythmias or progressive heart failure in the absence ofleft ventricular outflow obstruction. Therefore, an intervention to mitigate myocardial fibrosis would be potentially advantageous to hypertrophic cardiomyopathy patients. METHODS: Eligible hypertrophic cardiomyopathy patients were randomized 1:1 in a prospective double-blind fashion to spironolactone 50 mg or placebo to be taken over a 12-month period...
March 28, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29604277/jip3-deficiency-attenuates-cardiac-hypertrophy-by-suppression-of-jnk-pathway
#7
Qinghua Ma, Yuxiu Liu, Lianghua Chen
Pathological cardiac hypertrophy is a leading cause of morbidity and mortality worldwide; however, our understanding of the molecular mechanisms revealing the disease is still unclear. In the present study, we suggested that c-Jun N-terminal kinase (JNK)-interacting protein 3 (JIP3), involved in various cellular processes, played an essential role in regulating pathological cardiac hypertrophy through in vivo and in vitro studies. JIP3 was highly expressed in human hearts with hypertrophic cardiomyopathy (HCM), and in mouse hypertrophic hearts...
March 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29600783/a-secret-marriage-between-fibrosis-and-atrial-fibrillation-drivers
#8
EDITORIAL
Vadim V Fedorov, Brian J Hansen
No abstract text is available yet for this article.
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29600658/-protective-effect-of-dendrobium-candidum-on-isoproterenol-induced-cardiac-hypertrophy-in-rats
#9
Xiao-Chun Xiao, Wei-Hong Chen, Yuan-Yuan Cao, Yong-Jun Lou, Yuan Liu, Jin Wang, Xu-Feng Zhai, Nian-Sheng Li, Ying Li
To study the effect and mechanism of Dendrobium candidum on isoproterenol-induced myocardial hypertrophy in rats, 60 healthy SD rats(30 males and 30 females) were randomly divided into 5 groups(12 in each group): normal group, model group, three D. candidum preventive administration groups(0.09, 0.18, 1.1 g·kg⁻¹). Except for the normal group, rats of other groups were injected back subcutaneously with ISO(5 mg·kg⁻¹) for 10 consecutive days. At the same time, preventive administration groups began to give different doses of the sample for 30 days and model group began to give normal saline...
February 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29600485/diffuse-fibrosis-is-common-in-the-left-but-not-in-the-right-ventricle-in-patients-with-transposition-of-the-great-arteries-late-after-atrial-switch-operation
#10
Nerejda Shehu, Christian Meierhofer, Daniel Messroghli, Naira Mkrtchyan, Stefan Martinoff, Peter Ewert, Heiko Stern
In adult patients with transposition of the great arteries (TGA) late after atrial switch operation (AtSO), each of the ventricles is faced with a profoundly different pressure regimen from the one they are meant to support in normal conditions. The extent of diffuse fibrosis of the right ventricle (RV) and left ventricle (LV) in these patients remains incompletely investigated. Aim of this study was to quantify the degree of fibrosis of the unloaded LV and of the overloaded RV by determining the myocardial extracellular volume (ECV) with non-invasive techniques as T1 mapping...
March 29, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29596445/time-spent-with-cats-is-never-wasted-lessons-learned-from-feline-acromegalic-cardiomyopathy-a-naturally-occurring-animal-model-of-the-human-disease
#11
Kieran Borgeat, Stijn J M Niessen, Lois Wilkie, Norelene Harrington, David B Church, Virginia Luis Fuentes, David J Connolly
BACKGROUND: In humans, acromegaly due to a pituitary somatotrophic adenoma is a recognized cause of increased left ventricular (LV) mass. Acromegalic cardiomyopathy is incompletely understood, and represents a major cause of morbidity and mortality. We describe the clinical, echocardiographic and histopathologic features of naturally occurring feline acromegalic cardiomyopathy, an emerging disease among domestic cats. METHODS: Cats with confirmed hypersomatotropism (IGF-1>1000ng/ml and pituitary mass; n = 67) were prospectively recruited, as were two control groups: diabetics (IGF-1<800ng/ml; n = 24) and healthy cats without known endocrinopathy or cardiovascular disease (n = 16)...
2018: PloS One
https://www.readbyqxmd.com/read/29594338/macro-and-micromechanical-remodelling-in-the-fish-atrium-is-associated-with-regulation-of-collagen-1-alpha-3-chain-expression
#12
Adam N Keen, Andrew J Fenna, James C McConnell, Michael J Sherratt, Peter Gardner, Holly A Shiels
Numerous pathologies lead to remodelling of the mammalian ventricle, often associated with fibrosis. Recent work in fish has shown that fibrotic remodelling of the ventricle is 'reversible', changing seasonally as temperature-induced changes in blood viscosity alter haemodynamic load on the heart. The atrial response to varying haemodynamic load is less understood in mammals and completely unexplored in non-mammalian vertebrates. To investigate atrial remodelling, rainbow trout were chronically cooled (from 10 ± 1 to 5 ± 1 °C) and chronically warmed (from 10 ± 1 to 18 ± 1 °C) for a minimum of 8 weeks...
March 28, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29593565/aerobic-interval-training-prevents-age-dependent-vulnerability-to-atrial-fibrillation-in-rodents
#13
Vegard Malmo, Allen Kelly, Karin S Garten, Tomas Stolen, Natale P L Rolim, Ulrik Wisloff, Godfrey Smith, Jan P Loennechen
Aims: Increasing age is the most important risk factor for atrial fibrillation (AF). Very high doses of exercise training might increase AF risk, while moderate levels seem to be protective. This study aimed to examine the effects of age on vulnerability to AF and whether long-term aerobic interval training (AIT) could modify these effects. Methods: Nine months old, male Sprague-Dawley rats were randomized to AIT for 16 weeks (old-ex) or to a sedentary control group (old-sed), and compared to young sedentary males (young-sed)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29587379/galectin-3-in-atrial-fibrillation-mechanisms-and-therapeutic-implications
#14
REVIEW
Nicolas Clementy, Eric Piver, Arnaud Bisson, Clémentine Andre, Anne Bernard, Bertrand Pierre, Laurent Fauchier, Dominique Babuty
Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.
March 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29580170/comparison-of-therapeutic-triiodothyronine-versus-metoprolol-in-treatment-of-myocardial-infarction-in-rats
#15
Kuo Zhang, Yi-Da Tang, Youhua Zhang, Kaie Ojamaa, Ying Li, Amandeep Singh Saini, Maria Alicia Carrillo-Sepulveda, Viswanathan Rajagopalan, A Martin Gerdes
BACKGROUND: Beta blockers are standard therapy for myocardial infarction (MI). Preclinical studies have shown efficacy and safety of thyroid hormone (TH) treatment of cardiovascular disorders. Since THs interact with the sympathoadrenergic system, we aimed to compare triiodothyronine (T3) and metoprolol (Met) treatment of rats with MI on pathophysiology and TH-adrenergic signaling. METHODS: Female Sprague-Dawley rats aged 12 weeks underwent left anterior descending coronary artery ligation (MI) or sham surgeries...
March 26, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29579882/left-single-lung-transplantation-through-left-anterolateral-thoracotomy-with-longitudinal-partial-sternotomy-hemiclamshell-an-innovative-surgical-resource
#16
D A Murillo, F Cerezo, H D Gauman, F J Gonzalez, A Muñoz, P M Moreno, M J Ceballos, A Salvatierra
INTRODUCTION: Pulmonary fibrosis (PF) is one of the main indications for lung transplantation among end-stage respiratory diseases. PF represents a surgical challenge due to the pulmonary retraction, reduction of pleural space, and limitation for access of the lung hilum by elevation, specifically on the left lung. Unilateral sternothoracotomy, or hemiclamshell (HCS) approach, is the anterolateral thoracotomy with longitudinal partial sternotomy with possibility of cervical extension...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29578435/-the-role-of-marker-fibrosis-st2-and-angiotenzinogen-gene-polymorphism-in-heart-failure-progressing-in-patients-with-type-2-diabetes-mellitus
#17
I Rudyk, O Medentseva
Despite the progress in the treatment of HF, its prognosis remains disappointing primarily due to the fact that important subgroups of patients with HF are not sufficiently investigated. This also applies to patients with HF and background metabolic disorders, in particular, type 2 diabetes. It is known that the polymorphism of the rs699 marker of the M235T ATG gene is associated with a tendency to arterial hypertension, coronary heart disease and atrial fibrillation. A relationship was found between the polymorphism of M235T and the risk of HF development...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29569957/protein-tyrosine-phosphatase-1b-inactivation-limits-aging-associated-heart-failure-in-mice
#18
Marie Besnier, David Coquerel, Julie Favre, Anais Dumesnil, Dominique Guerrot, Isabelle Remy-Jouet, Paul Mulder, Zoubir Djerada, Fabienne Tamion, Vincent Richard, Antoine Ouvrard-Pascaud
Background- We previously showed that Protein Tyrosine Phosphatase 1B inactivation (PTP1B-/- ) in mice improved left ventricular (LV) angiogenesis, perfusion, remodeling and function, and limits endothelial dysfunction after myocardial infarction. However, whether PTP1B inactivation slows aging-associated cardiovascular dysfunction remains unknown. Methods and Results- WT and PTP1B-/- mice were allowed to age until 18 months. Compared to old WT in which aging increased the LV mRNA expression of PTP1B, old PTP1B-/- mice had: 1) reduced cardiac hypertrophy with decreased LV mRNA levels of hypertrophic markers, atrial and brain natriuretic peptides; 2) lower LV fibrosis (collagen: WT 16{plus minus}3, PTP1B-/- 5{plus minus}3 %, p<0...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29563373/fatal-cardiac-hemochromatosis-in-a-patient-with-hereditary-spherocytosis
#19
Takeo Fujino, Shujiro Inoue, Shunsuke Katsuki, Taiki Higo, Tomomi Ide, Yoshinao Oda, Hiroyuki Tsutsui
A 31-year-old man was admitted to our hospital with atrial tachycardia and cardiogenic shock. He had been diagnosed with hereditary spherocytosis (HS) during childhood, but he never received any red blood cell transfusions. Right ventricular endomyocardial biopsy revealed multiple myocardial hemosiderin deposits, and he was diagnosed with cardiac hemochromatosis. In addition to the iron deposition in the heart, the loss of myocyte and severe interstitial fibrosis were present. His cardiac function did not improve even after the cardioversion for atrial tachycardia, and he suffered from recurrent heart failure...
March 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29550319/myocardial-stiffness-evaluation-using-noninvasive-shear-wave-imaging-in-healthy-and-hypertrophic-cardiomyopathic-adults
#20
Olivier Villemain, Mafalda Correia, Elie Mousseaux, Jérome Baranger, Samuel Zarka, Ilya Podetti, Gilles Soulat, Thibaud Damy, Albert Hagège, Mickael Tanter, Mathieu Pernot, Emmanuel Messas
OBJECTIVES: The goal of our study was to investigate the potential of myocardial shear wave imaging (SWI) to quantify the diastolic myocardial stiffness (MS) (kPa) noninvasively in adult healthy volunteers (HVs) and its physiological variation with age, and in hypertrophic cardiomyopathy (HCM) populations with heart failure and preserved ejection function (HFpEF). BACKGROUND: MS is an important prognostic and diagnostic parameter of the diastolic function. MS is affected by physiological changes but also by pathological alterations of extracellular and cellular tissues...
March 9, 2018: JACC. Cardiovascular Imaging
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