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plant-based autoimmune treatment

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https://www.readbyqxmd.com/read/27334611/cannabimimetic-drugs-recent-patents-in-central-nervous-system-disorders
#1
Roberta Ranieri, Daniela Marasco, Maurizio Bifulco, Anna Maria Malfitano
Agents acting via cannabinoid receptors have been widely developed; starting from the chemical structure of phytocannabinoids isolated from cannabis sativa plant, specific and selective compounds of these receptors have been produced ranging from partial to full agonists and /or antagonists endowed with different potency. The enhanced interest on developing such classes of drugs is due to the beneficial properties widely reported by both anecdotal reports and scientific studies describing the potential medicinal use of cannabinoids and their derivatives in numerous pathological conditions in both in vitro and in vivo models...
June 19, 2016: Recent Patents on CNS Drug Discovery
https://www.readbyqxmd.com/read/26306744/induction-of-oral-tolerance-with-transgenic-plants-expressing-antigens-for-prevention-treatment-of-autoimmune-allergic-and-inflammatory-diseases
#2
REVIEW
Shengwu Ma, Yu-Cai Liao, Anthony M Jevnikar
The prevalence and incidence of autoimmune and allergic diseases have increased dramatically over the last several decades, especially in the developed world. The treatment of autoimmune and allergic diseases is typically with the use of non-specific immunosuppressive agents that compromise the integrity of the host immune system and therefore, increase the risk of infections. Antigenspecific immunotherapy by reinstating immunological tolerance towards self antigens without compromising immune functions is a much desired goal for the treatment of autoimmune and allergic diseases...
2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/24142387/comparative-analysis-of-different-biofactories-for-the-production-of-a-major-diabetes-autoantigen
#3
COMPARATIVE STUDY
Linda Avesani, Matilde Merlin, Elisa Gecchele, Stefano Capaldi, Annalisa Brozzetti, Alberto Falorni, Mario Pezzotti
The 65-kDa isoform of human glutamic acid decarboxylase (hGAD65) is a major diabetes autoantigen that can be used for the diagnosis and (more recently) the treatment of autoimmune diabetes. We previously reported that a catalytically-inactive version (hGAD65mut) accumulated to tenfold higher levels than its active counterpart in transgenic tobacco plants, providing a safe and less expensive source of the protein compared to mammalian production platforms. Here we show that hGAD65mut is also produced at higher levels than hGAD65 by transient expression in Nicotiana benthamiana (using either the pK7WG2 or MagnICON vectors), in insect cells using baculovirus vectors, and in bacterial cells using an inducible-expression system, although the latter system is unsuitable because hGAD65mut accumulates within inclusion bodies...
April 2014: Transgenic Research
https://www.readbyqxmd.com/read/23981406/safety-evaluation-and-therapeutic-efficacy-of-habb-e-asgand-a-commonly-used-antirheumatic-polyherbal-unani-formulation
#4
Mythily Subramaneyaan, Shagufta Yasmeen, Vinod Kumar Arora, Asok Kumar Tripathi, Basu Dev Banerjee, Rafat Sultana Ahmed
CONTEXT: Rheumatoid arthritis (RA) is a chronic autoimmune disorder. Habb-e-Asgand (HEA) is a polyherbal, Unani formulation widely used in the treatment of RA. Traditional systems of medicine or plant-based drugs are an attractive alternative treatment because of their professed efficacy in curing the disease. Medicinal herbs and herbal formulations are generally considered to be safer than the conventional drugs for RA. Unani drugs are known not to produce toxic effects and are presumed to be nontoxic...
September 2013: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/22971237/plants-and-plant-products-with-potential-antipsoriatic-activity-a-review
#5
REVIEW
Arshdeep Kaur, Suresh Kumar
CONTEXT: Psoriasis vulgaris is a hyper proliferative, autoimmune skin disorder affecting 1-3% of the world's population. The prescribed synthetic drugs for the treatment of psoriasis are associated with severe side effects, thus, researchers around the globe are searching for new, effective, and safer drugs from natural resources. OBJECTIVE: The present review has been prepared with an objective to compile exhaustive literature on pharmacological reports on antipsoriatic plants, plant products, and formulations...
December 2012: Pharmaceutical Biology
https://www.readbyqxmd.com/read/20673017/plant-made-pharmaceuticals-for-the-prevention-and-treatment-of-autoimmune-diseases-where-are-we
#6
REVIEW
Linda Avesani, Luisa Bortesi, Luca Santi, Alberto Falorni, Mario Pezzotti
Molecular farming in plants or plant cell cultures represents a viable alternative technology that holds great promise for the low-cost and large-scale production of recombinant proteins. The particular case of plant-based vaccines for the prevention of autoimmune diseases is addressed here, presenting a comprehensive overview of the different molecules and expression technologies that have been investigated so far in both academia and industry. The potential of plants not only as bioreactors but also as delivery systems for pharmaceuticals is discussed, and the advantages of oral delivery of autoantigens for the induction of immune tolerance are highlighted...
August 2010: Expert Review of Vaccines
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