Zoe Xiaofang Zhu, Yao Liu, Jinghao Wang, Ying Xie, Rachel Yuantong Li, Qian Ma, Qisheng Tu, Neiman A Melhem, Sandrine Couldwell, Rady E El-Araby, Albert Tai, Thomas E Van Dyke, Nadeem Karimbux, Y Natalie Jeong, Jake Jinkun Chen
Periodontitis is a highly prevalent chronic inflammatory disease with an exaggerated host immune response, resulting in periodontal tissue destruction and potential tooth loss. The long non-coding RNA, LncR-ANRIL, located on human chromosome 9p21, is recognized as a genetic risk factor for various conditions, including atherosclerosis, periodontitis, diabetes, and cancer. LncR-APDC is an ortholog of ANRIL located on mouse genome chr4. This study aims to comprehend the regulatory role of lncR-APDC in periodontitis progression...
2023: International Journal of Biological Sciences