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Jen Wang

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https://www.readbyqxmd.com/read/29453020/2018-consensus-of-the-taiwan-society-of-cardiology-and-the-diabetes-association-of-republic-of-china-taiwan-on-the-pharmacological-management-of-patients-with-type-2-diabetes-and-cardiovascular-diseases
#1
Chern-En Chiang, Shih-Yi Lin, Tsung-Hsien Lin, Tzung-Dau Wang, Hung-I Yeh, Jung-Fu Chen, Chia-Ti Tsai, Yi-Jen Hung, Yi-Heng Li, Ping-Yen Liu, Kuan-Cheng Chang, Kang-Ling Wang, Ting-Hsing Chao, Kou-Gi Shyu, Wei-Shiung Yang, Kwo-Chang Ueng, Pao-Hsien Chu, Wei-Hsian Yin, Yen-Wen Wu, Hao-Min Cheng, Shyi-Jang Shin, Chien-Ning Huang, Lee-Ming Chuang, Shing-Jong Lin, San-Jou Yeh, Wayne Huey-Herng Sheu, Jiunn-Lee Lin
The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). About two-thirds of death in type 2 diabetes are due to ASCVD, including 40% from coronary heart disease (CHD), 15% from heart failure (HF), and 10% from stroke. The association between hyperglycemia and elevated CV risk has been demonstrated in multiple cohort studies. However, clinical trials of intensive glucose reduction did not significantly reduce macrovascular outcomes...
February 13, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29444447/difference-between-observed-and-predicted-glycated-hemoglobin-at-baseline-and-treatment-response-to-vildagliptin-based-dual-oral-therapy-in-patients-with-type-2-diabetes
#2
Jun-Sing Wang, Yi-Jen Hung, Yung-Chuan Lu, Cheng-Lin Tsai, Wei-Shiung Yang, Ting-I Lee, Ya-Chun Hsiao, Wayne Huey-Herng Sheu
AIM: We aimed to investigate the association of difference between observed and predicted glycated hemoglobin (dopHbA1c) and HbA1c reduction after vildagliptin-based oral therapy in patients with type 2 diabetes (T2D). METHODS: This was a prospective observational study. Adults ≥20 years old with T2D and HbA1c ≧7% treated with oral anti-diabetic drugs (OADs) were eligible if their OADs were shifted to vildagliptin-based dual oral therapy. Fasting plasma glucose (FPG) and HbA1c were recorded at baseline, week 12, and week 24...
February 11, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29441520/methods-for-multivariate-recurrent-event-data-with-measurement-error-and-informative-censoring
#3
Hsiang Yu, Yu-Jen Cheng, Ching-Yun Wang
In multivariate recurrent event data regression, observation of recurrent events is usually terminated by other events that are associated with the recurrent event processes, resulting in informative censoring. Additionally, some covariates could be measured with errors. In some applications, an instrumental variable is observed in a subsample, namely a calibration sample, which can be applied for bias correction. In this article, we develop two non-parametric correction approaches to simultaneously correct for the informative censoring and measurement errors in the analysis of multivariate recurrent event data...
February 13, 2018: Biometrics
https://www.readbyqxmd.com/read/29440908/positive-correlation-of-the-serum-angiopoietin-like-protein-3-levels-with-the-aortic-augmentation-index-in-patients-with-coronary-artery-disease
#4
Yu-Shan Fu, Ji-Hung Wang, Chung-Jen Lee, Bang-Gee Hsu
Purpose: Angiopoietin-like protein 3 (ANGPTL3) plays an important role in lipid metabolism and angiogenesis and is elevated in familial hypercholesterolemia, metabolic syndrome, and insulin resistance. This study aims to evaluate the relationship between the fasting serum ANGPTL3 levels and the aortic augmentation index (AIx) in patients with coronary artery disease (CAD). Materials and methods: Fasting blood samples were obtained from 100 patients with CAD. The AIx was measured using a validated tonometry system (SphygmoCor)...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29440622/short-term-early-exposure-to-thirdhand-cigarette-smoke-increases-lung-cancer-incidence-in-mice
#5
Bo Hang, Yunshan Wang, Yurong Huang, Pin Wang, Sasha A Langley, Lei Bi, Altaf H Sarker, Suzaynn F Schick, Christopher Havel, Peyton Jacob, Neal Benowitz, Hugo Destaillats, Xiaochen Tang, Yankai Xia, Kuang-Yu Jen, Lara A Gundel, Jian-Hua Mao, Antoine Snijders
Exposure to thirdhand smoke (THS) is a recently described health concern that arises in many indoor environments. However, the carcinogenic potential of THS, a critical consideration in risk assessment, remains untested. Here we investigated the effects of short-term early exposure to THS on lung carcinogenesis in A/J mice. Forty weeks after THS exposure from 4 to-7 weeks of age, the mice had increased incidence of lung adenocarcinoma, tumor size and multiplicity, compared to controls. In vitro studies using cultured human lung cancer cells showed that THS exposure induced DNA double-strand breaks and increased cell proliferation and colony formation...
February 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29439943/cognitive-style-and-mobile-e-learning-in-emergent-otorhinolaryngology-head-and-neck-surgery-disorders-for-millennial-undergraduate-medical-students-randomized-controlled-trial
#6
Li-Ang Lee, Yi-Ping Chao, Chung-Guei Huang, Ji-Tseng Fang, Shu-Ling Wang, Cheng-Keng Chuang, Chung-Jan Kang, Li-Jen Hsin, Wan-Ni Lin, Tuan-Jen Fang, Hsueh-Yu Li
BACKGROUND: Electronic learning (e-learning) through mobile technology represents a novel way to teach emergent otorhinolaryngology-head and neck surgery (ORL-HNS) disorders to undergraduate medical students. Whether a cognitive style of education combined with learning modules can impact learning outcomes and satisfaction in millennial medical students is unknown. OBJECTIVE: The aim of this study was to assess the impact of cognitive styles and learning modules using mobile e-learning on knowledge gain, competence gain, and satisfaction for emergent ORL-HNS disorders...
February 13, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29438602/international-consensus-statement-on-allergy-and-rhinology-allergic-rhinitis
#7
Sarah K Wise, Sandra Y Lin, Elina Toskala, Richard R Orlandi, Cezmi A Akdis, Jeremiah A Alt, Antoine Azar, Fuad M Baroody, Claus Bachert, G Walter Canonica, Thomas Chacko, Cemal Cingi, Giorgio Ciprandi, Jacquelynne Corey, Linda S Cox, Peter Socrates Creticos, Adnan Custovic, Cecelia Damask, Adam DeConde, John M DelGaudio, Charles S Ebert, Jean Anderson Eloy, Carrie E Flanagan, Wytske J Fokkens, Christine Franzese, Jan Gosepath, Ashleigh Halderman, Robert G Hamilton, Hans Jürgen Hoffman, Jens M Hohlfeld, Steven M Houser, Peter H Hwang, Cristoforo Incorvaia, Deborah Jarvis, Ayesha N Khalid, Maritta Kilpeläinen, Todd T Kingdom, Helene Krouse, Desiree Larenas-Linnemann, Adrienne M Laury, Stella E Lee, Joshua M Levy, Amber U Luong, Bradley F Marple, Edward D McCoul, K Christopher McMains, Erik Melén, James W Mims, Gianna Moscato, Joaquim Mullol, Harold S Nelson, Monica Patadia, Ruby Pawankar, Oliver Pfaar, Michael P Platt, William Reisacher, Carmen Rondón, Luke Rudmik, Matthew Ryan, Joaquin Sastre, Rodney J Schlosser, Russell A Settipane, Hemant P Sharma, Aziz Sheikh, Timothy L Smith, Pongsakorn Tantilipikorn, Jody R Tversky, Maria C Veling, De Yun Wang, Marit Westman, Magnus Wickman, Mark Zacharek
BACKGROUND: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). METHODS: Using previously described methodology, specific topics were developed relating to AR...
February 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29434288/stem-cell-transplantation-for-t-cell-lymphomas-in-taiwan
#8
Ya-Ting Hsu, Hui-Jen Tsai, Jeffrey S Chang, Sin-Syue Li, Jih-Luh Tang, Su-Peng Yeh, Wen-Li Hwang, Jin-Hwang Liu, Tran-Der Tan, Po-Nan Wang, Hui-Hua Hsiao, Tsai-Yun Chen
T-cell lymphomas are generally aggressive malignancies with poor prognosis. There are no standard treatment guidelines for T-cell lymphomas, and the timing of stem cell transplantation (SCT) is not well known. In this study, we investigated the outcomes of Taiwanese patients with T-cell lymphomas after SCT. We retrospectively analyzed 131 patients with T-cell lymphomas receiving SCT (autologous: 90, allogeneic: 41) from 2009 to 2014. More autologous SCT recipients were ALCL or in complete remission, and more allogeneic recipients had advanced disease...
February 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29432710/serum-cystatin-c-is-independently-associated-with-aortic-arterial-stiffness-in-patients-with-type-2-diabetes
#9
I-Min Su, Du-An Wu, Chung-Jen Lee, Jia-Sian Hou, Bang-Gee Hsu, Ji-Hung Wang
BACKGROUND: Higher cystatin C levels are associated with an increased cardiovascular risk. We evaluated the association between serum cystatin C and aortic arterial stiffness in patients with type 2 diabetes mellitus (DM). METHODS: Fasting blood samples were collected from 170 patients with type 2 DM. Carotid-femoral pulse wave velocity (cfPWV) values > 10 m/s were used to define the high aortic arterial stiffness group. RESULTS: Sixty-seven patients with DM (39...
February 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29430220/esophageal-metastatic-adenocarcinoma-diagnosed-with-endoscopic-ultrasound
#10
Guo Xiang Jonathan Teh, Damien Tan, Jen Lock Khor, Wei Keat Wan, Yu Tien Wang
Metastasis to the esophagus from a distant primary cancer is a rare manifestation in a patient with a history of oncological disease presenting with obstructive upper gastrointestinal symptoms. Computed tomography of the thorax or esophagogastroduodenoscopy can be non-diagnostic as the disease tends to be submucosal. In such a situation, endoscopic ultrasound (EUS) with fine needle aspiration (FNA) can be directed to characterize and sample the submucosal esophageal lesion. We present a case series of metastatic esophageal strictures diagnosed with EUS and FNA...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29427840/generation-of-patient-specific-induced-pluripotent-stem-cells-from-leber-s-hereditary-optic-neuropathy
#11
Huai-En Lu, Yi-Ping Yang, Yan-Ting Chen, You-Ren Wu, Chia-Lin Wang, Fu-Ting Tsai, De-Kuang Hwang, Tai-Chi Lin, Shih-Jen Chen, An-Guor Wang, Patrick C H Hsieh, Shih-Hwa Chiou
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease caused by homoplasmic point mutations in complex I subunit genes of mitochondrial DNA. In this report, we generated an induced pluripotent stem cell (iPSCs) line, TVGH-iPSC-010-09, from the peripheral blood mononuclear cells of a female patient with Leber's hereditary optic neuropathy (LHON) by using the Sendai-virus delivery system. The resulting iPSCs retained the disease-causing mitochondrial DNA mutation, expressed pluripotent markers and could differentiate into the three germ layers...
January 31, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29426349/neurofibroma-involving-obturator-nerve-mimicking-an-adnexal-mass-a-rare-case-report-and-prisma-driven-systematic-review
#12
Wei-Ting Chao, Chia-Hao Liu, Yi-Jen Chen, Hua-Hsi Wu, Chi-Mu Chuang, Peng-Hui Wang
BACKGROUND: Pelvic masses are a common gynecologic problem, and majority of them are diagnosed as ovarian tumors finally. Sometimes, it is hard to distinguish the origin of these pelvic masses. The following case is a solitary neurofibroma arising from the right-side obturator nerve, which was impressed as a right-side ovarian tumor initially. We reported this case, and also performed a PRISMA-driven systematic review to summary the similar cases in the literature. This review includes image, molecular and pathological findings and outcome of neurofibroma...
February 9, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29422441/ambient-air-pollution-the-risk-of-stillbirth-a-prospective-birth-cohort-study-in-wuhan-china
#13
Shaoping Yang, Yafei Tan, Hui Mei, Fang Wang, Na Li, Jinzhu Zhao, Yiming Zhang, Zhengmin Qian, Jen Jen Chang, Kevin M Syberg, Anna Peng, Hong Mei, Dan Zhang, Yan Zhang, Shunqing Xu, Yuanyuan Li, Tongzhang Zheng, Bin Zhang
BACKGROUND: Recent studies suggest that ambient air pollution exposure during pregnancy is associated with stillbirth occurrence. However, the results on the associations between ambient air pollutants and stillbirths are inconsistent and little is known about the gestational timing of sensitive periods for the effects of ambient air pollutants exposure on stillbirth. OBJECTIVE: This study aimed to examine whether exposure to high levels of ambient air pollutants in a Chinese population is associated with an increased risk of stillbirth, and determine the gestational period when the fetus is most susceptible...
February 5, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29422288/systems-signatures-reveal-unique-remission-path-of-type-2-diabetes-following-roux-en-y-gastric-bypass-surgery
#14
Qing-Run Li, Zi-Ming Wang, Nicolai J Wewer Albrechtsen, Dan-Dan Wang, Zhi-Duan Su, Xian-Fu Gao, Qing-Qing Wu, Hui-Ping Zhang, Li Zhu, Rong-Xia Li, SivHesse Jacobsen, Nils Bruun Jørgensen, Carsten Dirksen, Kirstine N Bojsen-Møller, Jacob S Petersen, Sten Madsbad, Trine R Clausen, Børge Diderichsen, Luo-Nan Chen, Jens J Holst, Rong Zeng, Jia-Rui Wu
Roux-en-Y Gastric bypass surgery (RYGB) is emerging as a powerful tool for treatment of obesity and may also cause remission of type 2 diabetes. However, the molecular mechanism of RYGB leading to diabetes remission independent of weight loss remains elusive. In this study, we profiled plasma metabolites and proteins of 10 normal glucose-tolerant obese (NO) and 9 diabetic obese (DO) patients before and 1-week, 3-months, 1-year after RYGB. 146 proteins and 128 metabolites from both NO and DO groups at all four stages were selected for further analysis...
February 2, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29419706/rehabilitation-reduced-readmission-and-mortality-risks-in-patients-with-stroke-or-transient-ischemic-attack-a-population-based-study
#15
Ku-Chou Chang, Jen-Wen Hung, Hsuei-Chen Lee, Chu-Ling Yen, Ching-Yi Wu, Chung-Lin Yang, Yu-Ching Huang, Pei-Li Lin, Hui-Hsuan Wang
BACKGROUND: It remains unclear whether rehabilitation has an impact on reducing the long-term risk of mortality or readmission following stroke or transient ischemic attack (TIA). OBJECTIVES: To investigate the association between the dosage and continuation of rehabilitation and the risk of outcome events (OEs) after stroke or TIA. RESEARCH DESIGN: A retrospective cohort study using Taiwan's National Health Insurance database. SUBJECTS: In total, 4594 patients admitted with first-ever acute stroke or TIA were followed-up for 32 months...
February 6, 2018: Medical Care
https://www.readbyqxmd.com/read/29419634/are-there-age-and-sex-related-differences-in-spinal-sagittal-alignment-and-balance-among-taiwanese-asymptomatic-adults
#16
Kuang-Ting Yeh, Ru-Ping Lee, Ing-Ho Chen, Tzai-Chiu Yu, Cheng-Huan Peng, Kuan-Lin Liu, Jen-Hung Wang, Wen-Tien Wu
BACKGROUND: Sagittal spinopelvic balance and proper sagittal alignment are important when planning corrective or reconstructive spinal surgery. Prior research suggests that people from different races and countries have moderate divergence; to the best of our knowledge, the population of Taiwan has not been studied with respect to this parameter. QUESTIONS/PURPOSES: To investigate normal age- and sex-related differences in whole-spine sagittal alignment and balance of asymptomatic adults without spinal disorders...
February 5, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29416815/increased-risk-of-malignancy-in-patients-with-an-aortic-aneurysm-a-nationwide-population-based-retrospective-study
#17
Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Wen-I Liao, Chang-Huei Tsao, Yung-Fu Wu, Shih-Hung Tsai
Background: Cardiovascular disease and malignancy have numerous similarities and possible interactions, as these diseases share several risk factors, epidemiological features and biological signaling pathways. Data regarding the risk of malignancy in patients with aortic aneurysm (AA) are scarce. We aimed to determine whether patients with AA have an increased risk of malignancy. Materials and Methods: The data for the nationwide population-based retrospective cohort study described herein were obtained from the Taiwan National Health Insurance Research Database (NHIRD)...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416717/phosphorylated-heat-shock-protein-27-as-a-potential-biomarker-to-predict-the-role-of-chemotherapy-induced-autophagy-in-osteosarcoma-response-to-therapy
#18
Janice M Santiago-O'Farrill, Eugenie S Kleinerman, Mario G Hollomon, Andrew Livingston, Wei-Lien Wang, Jen-Wei Tsai, Nancy B Gordon
Autophagy is a catabolic process involved in cellular homeostasis. Autophagy is increased above homeostatic levels by chemotherapy, and this can either promote or inhibit tumor growth. We previously demonstrated that aerosol gemcitabine (GCB) has a therapeutic effect against osteosarcoma (OS) lung metastases. However, some tumor cells failed to respond to the treatment and persisted as isolated lung metastasis. Here, we examined the mechanisms underlying the dual role of chemotherapy-induced autophagy in OS and sought to identify biomarkers to predict OS response to treatment...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414668/garcinol-inhibits-cancer-stem-cell-like-phenotype-via-suppression-of-the-wnt-%C3%AE-catenin-stat3-axis-signalling-pathway-in-human-non-small-cell-lung-carcinomas
#19
Wen-Chien Huang, Kuang-Tai Kuo, Bamodu Oluwaseun Adebayo, Chun-Hua Wang, Yu-Jen Chen, Ketao Jin, Tung-Hu Tsai, Chi-Tai Yeh
Innate or acquired drug resistance and consequent tumor relapse in lung cancer patients have been linked to activities of cancer stem cells (CSCs). Therefore, targeting CSCs is suggested as an effective approach for non-small cell lung cancer (NSCLC) therapy. In this study, we demonstrated that garcinol, a polyisoprenylated benzophenone isolated from fruiting bodies of Garcinia indica, and possessing anti-inflammatory, antioxidant, acetyltransferase inhibitory, and anticancer activities, modulates activities of lung CSCs (LCSCs) and their associated aggressiveness...
December 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29411558/interactions-between-bisphenol-a-exposure-and-gstp1-polymorphisms-in-childhood-asthma
#20
Tien Jen Lin, Wilfried J J Karmaus, Mei Lien Chen, Jiin Chyr Hsu, I Jen Wang
PURPOSE: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione S-transferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. METHODS: We conducted a case-control study comprised of 126 asthmatic children and 327 controls...
March 2018: Allergy, Asthma & Immunology Research
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