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Jen Wang

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https://www.readbyqxmd.com/read/28214764/recurrent-falls-and-its-risk-factors-among-older-men-living-in-the-veterans-retirement-communities-a-cross-sectional-study
#1
Cheng-Hao Hung, Chih-Jen Wang, Ting-Ching Tang, Liang-Yu Chen, Li-Ning Peng, Fei-Yuan Hsiao, Liang-Kung Chen
AIM: To evaluate the prevalence of recurrent falls and their risk factors among older men living in the Veterans Homes in Taiwan. METHODS: This cross-sectional study enrolled 871 residents and all participants received the comprehensive geriatric assessment, including Barthel Index, Mini-Mental Status Examination (MMSE), Geriatric Depression Scale-5 questions (GDS-5), Mini-Nutrition Assessment Short Form (MNA-SF), the status of urinary incontinence, stool incontinence, polypharmacy, past history of falls, multimorbidity, and medication history...
February 4, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28209946/pdgfr%C3%A1%C2%B5-rearranged-myeloid-neoplasm-with-marked-eosinophilia-in-a-37-year-old-man-and-a-literature-review
#2
Mirela Andrei, Andrei Bandarchuk, Cherif Abdelmalek, Ajay Kundra, Vladimir Gotlieb, Jen Chin Wang
BACKGROUND PDGFRᵝ-positive myeloid neoplasms are rare. Marked leukocytosis (over 100×10⁹/L) with marked eosinophilia (over 10%) has been rarely described in myeloid neoplasms associated with PDGFRᵝ rearrangement. CASE REPORT We report a case of 37-year-old man with myeloid neoplasm associated with PDGFRᵝ rearrangement who presented with marked eosinophilia of 13.3% and leukocytosis with WBC count of 189×10⁹/L. He was found to have PDGFRᵝ locus rearrangement at 5q32-33 by fluorescent in situ hybridization (FISH)...
February 17, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28209629/burden-of-musculoskeletal-disorders-in-the-eastern-mediterranean-region-1990-2013-findings-from-the-global-burden-of-disease-study-2013
#3
Maziar Moradi-Lakeh, Mohammad H Forouzanfar, Stein Emil Vollset, Charbel El Bcheraoui, Farah Daoud, Ashkan Afshin, Raghid Charara, Ibrahim Khalil, Hideki Higashi, Mohamed Magdy Abd El Razek, Aliasghar Ahmad Kiadaliri, Khurshid Alam, Nadia Akseer, Nawal Al-Hamad, Raghib Ali, Mohammad AbdulAziz AlMazroa, Mahmoud A Alomari, Abdullah A Al-Rabeeah, Ubai Alsharif, Khalid A Altirkawi, Suleman Atique, Alaa Badawi, Lope H Barrero, Mohammed Basulaiman, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Isabela M Bensenor, Rachelle Buchbinder, Hadi Danawi, Samath D Dharmaratne, Faiez Zannad, Maryam S Farvid, Seyed-Mohammad Fereshtehnejad, Farshad Farzadfar, Florian Fischer, Rahul Gupta, Randah Ribhi Hamadeh, Samer Hamidi, Masako Horino, Damian G Hoy, Mohamed Hsairi, Abdullatif Husseini, Mehdi Javanbakht, Jost B Jonas, Amir Kasaeian, Ejaz Ahmad Khan, Jagdish Khubchandani, Ann Kristin Knudsen, Jacek A Kopec, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Azeem Majeed, Reza Malekzadeh, Kedar Mate, Alem Mehari, Michele Meltzer, Ziad A Memish, Mojde Mirarefin, Shafiu Mohammed, Aliya Naheed, Carla Makhlouf Obermeyer, In-Hwan Oh, Eun-Kee Park, Emmanuel Kwame Peprah, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Vafa Rahimi-Movaghar, Rahman Shiri, Sajjad Ur Rahman, Rajesh Kumar Rai, Saleem M Rana, Sadaf G Sepanlou, Masood Ali Shaikh, Ivy Shiue, Abla Mehio Sibai, Diego Augusto Santos Silva, Jasvinder A Singh, Jens Christoffer Skogen, Abdullah Sulieman Terkawi, Kingsley N Ukwaja, Ronny Westerman, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Zoubida Zaidi, Maysaa El Sayed Zaki, Stephen S Lim, Haidong Wang, Theo Vos, Mohsen Naghavi, Alan D Lopez, Christopher J L Murray, Ali H Mokdad
OBJECTIVES: We used findings from the Global Burden of Disease Study 2013 to report the burden of musculoskeletal disorders in the Eastern Mediterranean Region (EMR). METHODS: The burden of musculoskeletal disorders was calculated for the EMR's 22 countries between 1990 and 2013. A systematic analysis was performed on mortality and morbidity data to estimate prevalence, death, years of live lost, years lived with disability and disability-adjusted life years (DALYs)...
February 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28209488/postoperative-maintenance-levonorgestrel-releasing-intrauterine-system-and-endometrioma-recurrence-a-randomized-controlled-study
#4
Yi-Jen Chen, Teh-Fu Hsu, Ben-Shian Huang, Hsiao-Wen Tsai, Yen-Hou Chang, Peng-Hui Wang
BACKGROUND: According to three randomized trials, levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis- related pelvic pain at postoperative year 1. Only a few studies have evaluated the long-term effectiveness of the devicefor preventing endometrioma recurrence, and the effects of a levonorgestrel-releasing intrauterine system as a maintenance therapy remain unclear. OBJECTIVES: To evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28208751/oxidative-stress-related-genetic-variants-may-modify-associations-of-phthalate-exposures-with-asthma
#5
I-Jen Wang, Wilfried J J Karmaus
Background: Phthalate exposure may increase the risk of asthma. Little is known about whether oxidative-stress related genes may alter this association. First, this motivated us to investigate whether genetic polymorphisms of the oxidative-stress related genes glutathione S-transferase Mu 1 (GSTM1), glutathione S-transferase pi 1 (GSTP1), superoxide dismutase 2 (SOD2), catalase (CAT), myeloperoxidase (MPO), and EPHX1 in children are associated with phthalate urine concentrations. Second, we addressed the question whether these genes may affect the influence of phthalates on asthma...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28205526/association-evidence-of-ccttt-repeat-polymorphism-in-the-inos-promoter-and-the-risk-of-atrial-fibrillation-in-taiwanese
#6
Lung-An Hsu, Yung-Hsin Yeh, Wei-Jan Chen, Chi-Tai Kuo, Feng-Chun Tsai, Yi-Hsin Chan, Chun-Li Wang, Chi-Jen Chang, Hsin-Yi Tsai
Inducible nitric oxide synthase (iNOS) plays an important role in the pathogenesis of atrial fibrillation (AF). The iNOS promoter has a CCTTT-repeat length polymorphism that can determine the level of gene transcription. This study enrolled 200 AF patients and 240 controls. The length of CCTTT-repeat polymorphism in the iNOS promoter region was examined by polymerase chain reactions, with the alleles with ≤11 repeats designated as S and alleles with ≥12 repeats designated as L alleles. AF patients carried significantly higher frequencies of the LL genotype than control subjects (40...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203414/advanced-primary-pulmonary-lymphoepithelioma-like-carcinoma-clinical-manifestations-treatment-and-outcome
#7
Chun-Yu Lin, Ying-Jen Chen, Meng-Heng Hsieh, Chih-Wei Wang, Yueh-Fu Fang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is rare, with better clinical outcomes than other lung cancers. However, reports on advanced LELC characteristics and prognosis are lacking. METHODS: This retrospective study included adults diagnosed with advanced LELC (at least stage IIIA) between January 2003 and December 2015. Clinical characteristics, treatment modalities, and outcomes were recorded. RESULTS: Study population comprised 23 patients with a mean age of 63...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28199345/impact-of-chronic-rhinosinusitis-on-severe-asthma-patients
#8
Ta-Jen Lee, Chia-Hsiang Fu, Chun-Hua Wang, Chi-Che Huang, Chien-Chia Huang, Po-Hung Chang, Yi-Wei Chen, Chia-Chen Wu, Ching-Lung Wu, Han-Pin Kuo
Coexistence of chronic rhinosinusitis (CRS) with asthma appears to impair asthma control. Type-2 innate lymphoid cells (ILC2s) respond to the cytokines of thymic stromal lymphopoietin (TSLP), interleukin (IL)-25 and IL-33, thus contributing to airway diseases such as CRS and asthma. We investigate whether the augmented Th2-cytokines in CRS might be related to sinonasal tract ILC2s corresponding to enhanced IL-25, IL-33 and TSLP release in severe asthmatics, and be involved in asthma control. Twenty-eight asthmatics (12 non-severe and 16 severe) with CRS receiving nasal surgery were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28198673/diversity-and-enterotype-in-gut-bacterial-community-of-adults-in-taiwan
#9
Chao Liang, Han-Chi Tseng, Hui-Mei Chen, Wei-Chi Wang, Chih-Min Chiu, Jen-Yun Chang, Kuan-Yi Lu, Shun-Long Weng, Tzu-Hao Chang, Chao-Hsiang Chang, Chen-Tsung Weng, Hwei-Ming Wang, Hsien-Da Huang
BACKGROUND: Gastrointestinal microbiota, particularly gut microbiota, is associated with human health. The biodiversity of gut microbiota is affected by ethnicities and environmental factors such as dietary habits or medicine intake, and three enterotypes of the human gut microbiome were announced in 2011. These enterotypes are not significantly correlated with gender, age, or body weight but are influenced by long-term dietary habits. However, to date, only two enterotypes (predominantly consisting of Bacteroides and Prevotella) have shown these characteristics in previous research; the third enterotype remains ambiguous...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28197628/resveratrol-induced-autophagy-and-apoptosis-in-cisplatin-resistant-human-oral-cancer-car-cells-a-key-role-of-ampk-and-akt-mtor-signaling
#10
Chao-Hsiang Chang, Chao-Ying Lee, Chi-Cheng Lu, Fuu-Jen Tsai, Yuan-Man Hsu, Je-Wei Tsao, Yu-Ning Juan, Hong-Yi Chiu, Jai-Sing Yang, Ching-Chiung Wang
Resveratrol is known to be an effective chemo-preventive phytochemical against multiple tumor cells. However, the increasing drug resistance avoids the cancer treatment in oral cavity cancer. In this study, we investigated the oral antitumor activity of resveratrol and its mechanism in cisplatin-resistant human oral cancer CAR cells. Our results demonstrated that resveratrol had an extremely low toxicity in normal oral cells and provoked autophagic cell death to form acidic vesicular organelles (AVOs) and autophagic vacuoles in CAR cells by acridine orange (AO) and monodansylcadaverine (MDC) staining...
March 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28196060/angiographic-subtypes-of-polypoidal-choroidal-vasculopathy-in-taiwan-a-prospective-multicenter-study
#11
Ling Yeung, Chien-Neng Kuo, An-Ning Chao, Kuan-Jen Chen, Wei-Chi Wu, Chien-Hsiung Lai, Nan-Kai Wang, Yih-Shiou Hwang, Ching-Lung Chen, Chi-Chun Lai
PURPOSE: To determine the incidence and clinical characteristics of angiographic subtypes of polypoidal choroidal vasculopathy (PCV). METHODS: It is a prospective, multicenter, cross-sectional study. Patients with newly diagnosed exudative macular degeneration are classified into PCV, age-related macular degeneration (AMD), and retinal angiomatous proliferation. Polypoidal choroidal vasculopathy is further classified into two subtypes depending on the presence (Type 1: polypoidal choroidal neovascularization) or absence (Type 2: typical PCV) of feeder vessels on indocyanine green angiography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28195981/clinical-features-in-a-case-of-occult-macular-dystrophy-with-rp1l1-mutation
#12
Yun Fu, Kuan-Jen Chen, Chi-Chun Lai, Wei-Chi Wu, Nan-Kai Wang
PURPOSE: To investigate appropriate diagnostic testing for occult macular dystrophy (OMD) in a patient with unexplained progressive visual loss. METHODS: Observational case report. RESULTS: Occult macular dystrophy is an uncommon autosomal dominant macular disease, but sporadic occurrences have been noted. We report a patient with progressive visual decline, but with normal findings in fundus photography, visual field, fluorescein angiography, and full-field standard electroretinography...
February 10, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28194177/fatty-liver-index-and-lipid-accumulation-product-can-predict-metabolic-syndrome-in-subjects-without-fatty-liver-disease
#13
Yuan-Lung Cheng, Yuan-Jen Wang, Keng-Hsin Lan, Teh-Ia Huo, Yi-Hsiang Huang, Chien-Wei Su, Wei-Yao Hsieh, Ming-Chih Hou, Han-Chieh Lin, Fa-Yauh Lee, Jaw-Ching Wu, Shou-Dong Lee
Background. Fatty liver index (FLI) and lipid accumulation product (LAP) are indexes originally designed to assess the risk of fatty liver and cardiovascular disease, respectively. Both indexes have been proven to be reliable markers of subsequent metabolic syndrome; however, their ability to predict metabolic syndrome in subjects without fatty liver disease has not been clarified. Methods. We enrolled consecutive subjects who received health check-up services at Taipei Veterans General Hospital from 2002 to 2009...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28193996/a-case-report-of-primary-nasal-natural-killer-nk-t-cell-lymphoma-in-an-african-american-patient-presenting-with-hemophagocytic-syndrome
#14
Bowei Tan, Cherif Abdelmalek, James E O'Donnell, Thomas Toltaku, Rashid Chaudhry, Jen C Wang, Vladimir Gotlieb
BACKGROUND Extranodal natural killer/T-cell lymphoma, nasal type (ENKTCL) is generally an aggressive and rare non-Hodgkin lymphoma. It is most common in East Asians, Native Americans, and South Americans, but is rarely reported in blacks. CASE REPORT A 55-year-old African American male born in Grenada presented with a left nostril mass with facial swelling and biopsy subsequently confirmed a diagnosis of extranodal NK/T-cell lymphoma, nasal type (ENKTCL). Immunochemistry was positive for CD2, cytoplasmic CD3, CD7, CD 43, CD 56, granzyme B, and TIA-1...
February 14, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28190667/repeated-episodes-of-acute-stroke-as-manifestation-of-neurosyphilis-in-a-well-controlled-human-immunodeficiency-virus-infected-patient-successful-treatment-with-ceftriaxone
#15
Tsung-Chia Chen, Jen-Hsien Wang, Tzung-Chang Tsai
No abstract text is available yet for this article.
February 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28190545/prevalence-of-depressive-disorder-in-persons-with-type-2-diabetes-a-national-population-based-cohort-study-2000-2010
#16
Hung-Pin Tu, Hui-Min Hsieh, Tai-Ling Liu, He-Jiun Jiang, Peng-Wei Wang, Chun-Jen Huang
BACKGROUND: Diabetes mellitus, a chronic and disabling disease, is epidemic worldwide. Depressive disorder affects the productivity of workers and leads to disability. OBJECTIVE: This study investigated the prevalence of depressive disorder among persons with type 2 diabetes in Taiwan. METHODS: We extracted service claims data for subjects who had at least 2 ambulatory care service claims or 1 inpatient service claim with a principal diagnosis of type 2 diabetes and at least 1 ambulatory or inpatient service claim with a principal diagnosis of depressive disorder from Taiwan's National Health Insurance Database...
November 17, 2016: Psychosomatics
https://www.readbyqxmd.com/read/28183528/transethnic-genome-wide-scan-identifies-novel-alzheimer-s-disease-loci
#17
Gyungah R Jun, Jaeyoon Chung, Jesse Mez, Robert Barber, Gary W Beecham, David A Bennett, Joseph D Buxbaum, Goldie S Byrd, Minerva M Carrasquillo, Paul K Crane, Carlos Cruchaga, Philip De Jager, Nilufer Ertekin-Taner, Denis Evans, M Danielle Fallin, Tatiana M Foroud, Robert P Friedland, Alison M Goate, Neill R Graff-Radford, Hugh Hendrie, Kathleen S Hall, Kara L Hamilton-Nelson, Rivka Inzelberg, M Ilyas Kamboh, John S K Kauwe, Walter A Kukull, Brian W Kunkle, Ryozo Kuwano, Eric B Larson, Mark W Logue, Jennifer J Manly, Eden R Martin, Thomas J Montine, Shubhabrata Mukherjee, Adam Naj, Eric M Reiman, Christiane Reitz, Richard Sherva, Peter H St George-Hyslop, Timothy Thornton, Steven G Younkin, Badri N Vardarajan, Li-San Wang, Jens R Wendlund, Ashley R Winslow, Jonathan Haines, Richard Mayeux, Margaret A Pericak-Vance, Gerard Schellenberg, Kathryn L Lunetta, Lindsay A Farrer
BACKGROUND: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset...
February 6, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28179311/telomere-length-and-risk-of-hepatocellular-carcinoma-a-nested-case-control-study-in-taiwan-cancer-screening-program-cohort
#18
Hui Zeng, Hui-Chen Wu, Qiao Wang, Hwai-I Yang, Chien-Jen Chen, Regina M Santella, Jing Shen
BACKGROUND: Telomere length (TL) measured in peripheral blood leucocytes (PBL) might be a useful biomarker to identify elevated cancer risk. PATIENTS AND METHODS: A case-control study which included 268 newly-diagnosed HCC cases and 536 matched controls, was conducted. Absolute TL in PBL was analyzed by quantitative real-time PCR. RESULTS: The overall median length of TL was not statistically shorter in HCC cases compared to healthy controls...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178601/bone-health-among-older-adults-in-taiwan
#19
Wei-Jen Wang, Kuan-Liang Kuo, Chen-Kun Liaw, Tai-Yin Wu, Wei-Chu Chie, Jer-Min Chen
BACKGROUND AND PURPOSE: There has been much discussion about the risk factors for osteoporosis, but studies involving elderly population in Taiwan are minimal. We aimed to describe variables related to osteoporosis among community dwelling older people in Taiwan. METHODS: This is a cross-sectional study. The 671 participants were randomly selected from 3680 examinees of the annual Senior Citizens Health Examination in year 2010. Participants were interviewed with a detailed questionnaire, and 91 of them were invited for dual-energy X-ray absorptiometry (DXA)...
January 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28175985/polycyclic-aromatic-hydrocarbons-exposure-oxidative-stress-and-asthma-in-children
#20
I-Jen Wang, Wilfried J J Karmaus, Chen-Chang Yang
PURPOSE: Polycyclic aromatic hydrocarbons (PAHs) are known for their carcinogenic and teratogenic properties. However, little is known about the effect of PAH on our immune and respiratory systems. Hence, we investigated associations (1) between PAH exposure and IgE levels and asthma in children and (2) between PAH exposure and the oxidative stress marker 8OHdG potentially involved in disease pathogenesis stratifying by (3) sex-based differences. METHODS: A total of 453 kindergarten children were recruited and provided samples...
February 7, 2017: International Archives of Occupational and Environmental Health
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