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Jen Wang

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https://www.readbyqxmd.com/read/29233482/comparison-of-single-port-and-three-port-laparoscopic-salpingectomy-in-the-management-for-tubal-pregnancy
#1
Hsu-Dong Sun, Huann-Cheng Horng, Chia-Hao Liu, Sheng-Mou Hsiao, Yi-Jen Chen, Wen-Hsun Chang, Peng-Hui Wang
BACKGROUND: To compare the short-term outcome of patients undergoing single-port laparoscopic salpingectomy (SP-LS) and conventional three-port laparoscopic salpingectomy (C-LS). METHODS: A retrospective evaluation of 112 patients with tubal pregnancies treated by one surgeon at a single teaching hospital. Among these, 47 patients were treated with SP-LS and the remaining 65 were treated with C-LS. RESULTS: The characteristics of patients were similar in both groups...
December 7, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29232591/impact-of-time-on-ultrasonic-cavitation-peening-via-detection-of-surface-plastic-deformation
#2
Fushi Bai, Kai-Alexander Saalbach, Liang Wang, Xiaogeng Wang, Jens Twiefel
During ultrasonic cavitation peening, bubbles repeatedly form and collapse, which leads to high impact loads on the treated surface. At the initial stage of ultrasonic cavitation peening, the most obvious change is plastic deformation instead of mass loss on the treated specimen surface. Meanwhile the plastic deformation is beneficial for mechanical surface properties. As the cavitation exposure time increases, erosion and damage are inflicted on the metal surface due to the increase in the number of collapse events...
December 5, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29231709/chemoselective-dual-and-triple-labelling-of-native-and-recombinant-proteins
#3
Bikram Keshari Agrawalla, Tao Wang, Andreas Riegger, Matthias P Domogalla, Kerstin Steinbrink, Thilo Dörfler, Xi Chen, Felix Boldt, Markus Lamla, Jens Michaelis, Seah Ling Kuan, Tanja Weil
The attachment of two or more different functionalities in a site-selective fashion represents a great challenge in protein chemistry. We report multiple functionalization of peptides and proteins capitalizing on reactivity differences of cysteines in their free (thiol) and protected, oxidized (disulfide) forms. The dual and triple functionalization of interleukin 2 and EYFP proceeded with no loss of bio-activity in a stepwise fashion applying maleimide and disulfide rebridging allyl-sulfone groups. In order to ensure broader applicability of the functionalization strategy, a novel, short peptide sequence that introduces a disulfide bridge was designed and site-selective triple labelling in the presence of biogenic groups was successfully demonstrated...
December 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29230929/application-of-protoplast-technology-to-crispr-cas9-mutagenesis-from-single-cell-mutation-detection-to-mutant-plant-regeneration
#4
Choun-Sea Lin, Chen-Tran Hsu, Ling-Hung Yang, Lan-Ying Lee, Jin-Yuan Fu, Qiao-Wei Cheng, Fu-Hui Wu, Han Chen-Wei Hsiao, Yesheng Zhang, Ru Zhang, Wan-Jung Chang, Chen-Ting Yu, Wen Wang, Li-Jen Liao, Stanton B Gelvin, Ming-Che Shih
Plant protoplasts are useful for assessing the efficiency of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR Associated Protein 9 (Cas9) mutagenesis. We improved the process of protoplast isolation and transfection of several plant species. We also developed a method to isolate and regenerate single mutagenized Nicotianna tabacum protoplasts into mature plants. Following transfection of protoplasts with constructs encoding Cas9 and sgRNAs, target gene DNA could be amplified for further analysis to determine mutagenesis efficiency...
December 12, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29230255/control-of-cell-proliferation-by-a-porous-chitosan-scaffold-with-multiple-releasing-capabilities
#5
Shu-Jyun Cai, Ching-Wen Li, Daphne Weihs, Gou-Jen Wang
The aim of this study was to develop a porous chitosan scaffold with long-acting drug release as an artificial dressing to promote skin wound healing. The dressing was fabricated by pre-freezing at different temperatures (-20 and -80 °C) for different periods of time, followed by freeze-drying to form porous chitosan scaffolds with different pore sizes. The chitosan scaffolds were then used to investigate the effect of the controlled release of fibroblast growth factor-basic (bFGF) and transforming growth factor-β1 (TGFβ1) on mouse fibroblast cells (L929) and bovine carotid endothelial cells (BEC)...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/29228697/egfr-mutation-smoking-and-gender-in-advanced-lung-adenocarcinoma
#6
Chien-Hua Tseng, Chun-Ju Chiang, Jeng-Sen Tseng, Tsung-Ying Yang, Kuo-Hsuan Hsu, Kun-Chieh Chen, Chih-Liang Wang, Chih-Yi Chen, Sang-Hue Yen, Chun-Ming Tsai, Ming-Shyan Huang, Chao-Chi Ho, Chong-Jen Yu, Ying-Huang Tsai, Jin-Shing Chen, Teh-Ying Chou, Ming-Hsun Tsai, Hsuan-Yu Chen, Kang-Yi Su, Jeremy J W Chen, Huei-Wen Chen, Sung-Liang Yu, Tsang-Wu Liu, Gee-Chen Chang
Purpose: In the current targeted therapy era, information on the effect of smoking in epidermal growth factor receptor (EGFR)-mutant lung cancer patients is scarce. Results: In total, 11,678 adenocarcinoma patients were enrolled. Of these, 33.3% and 91.8% of male and female patients were non-smokers, respectively. An increased amount of smoking (P < 0.001 for trend), fewer smoke-free years (P < 0.001 for trend), and younger age of smoking initiation (P = 0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224816/hypermethylated-znf582-and-pax1-genes-in-oral-scrapings-collected-from-cancer-adjacent-normal-oral-mucosal-sites-are-associated-with-aggressive-progression-and-poor-prognosis-of-oral-cancer
#7
Shih-Jung Cheng, Chi-Feng Chang, Hui-Hsin Ko, Yi-Ching Liu, Hsin-Hui Peng, Huei-Jen Wang, Hsiao-Shan Lin, Chun-Pin Chiang
OBJECTIVE: This study assessed whether hypermethylated ZNF582 and PAX1 genes in oral scrapings are correlated with the progression and prognosis of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: Methylation levels of ZNF582 and PAX1 genes in oral scrapings, collected from the cancer and adjacent normal oral mucosal sites of 80 OSCC patients before surgical cancer excision, were quantified using real-time methylation-specific PCR after bisulfite conversion...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29224434/percutaneous-intervention-to-correct-central-venous-port-catheter-malposition
#8
Yen-Hsiang Wang, Chieh-Shou Su, Keng-Hao Chang, Chi-Jen Went, Wen-Lieng Lee, Chih-Hung Lai
The use of central venous port access is increasing due to the requirements of multimodal intravenous therapy.1 However, catheter malposition in smaller veins can lead to vein thrombosis, phlebitis and pain. Herein, we report our experience with the use of percutaneous interventions to correct migrated port catheter malposition. Minimally invasive percutaneous interventional correction of malposition could be an alternative to extraction and re-implantation of malpositioned port catheters.
December 1, 2017: Perfusion
https://www.readbyqxmd.com/read/29223148/exhaled-nitric-oxide-helps-discriminating-asthmatic-children-with-and-without-positive-specific-ige-to-aeroallergens
#9
Li-Ching Fang, Shyh-Dar Shyur, Jun Yang, Jen-Yu Wang, Yu-Hsuan Kao, Chien-Hui Yang, Yu-Ting Yu
BACKGROUND: Aeroallergen sensitization may predict higher fractional exhaled nitric oxide (FeNO) levels. OBJECTIVE: We evaluate cut-off values of FeNO in asthmatic children with and without positive specific immunoglobulin E (IgE) to at least one of 5 aeroallergens (Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat, dog, and cockroach). METHODS: 564 patients with asthma and allergic rhinitis (AR) aged 5 to 18 years were enrolled into two groups...
December 10, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29221788/differential-prevalence-of-hematuria-and-proteinuria-with-socio-demographic-factors-among-school-children-in-hualien-taiwan
#10
Ming-Chun Chen, Jen-Hung Wang, Chia-Hsiang Chu, Ching-Feng Cheng
BACKGROUND: Pediatric hematuria/proteinuria is a risk factor for chronic kidney disease in later life, and school urinary screening can detect asymptomatic glomerulonephritis in the early stage. This study aimed to evaluate the prevalence of hematuria/proteinuria and its association with different socio-demographic factors among school children in 2013 in Hualien, Taiwan. METHODS: A cross-sectional study was conducted among first, fourth, and seventh graders. Health examination results and urinalysis data were analyzed...
November 21, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29221344/endoscopic-diverticulotomy-with-a-stapler-can-be-an-effective-and-safe-treatment-for-killian-jamieson-diverticulum
#11
Po-Jen Yun, Hsu-Kai Huang, Hung Chang, Shih-Chun Lee, Tsai-Wang Huang
Killian-Jamieson diverticulum (KJD) is a rarely encountered esophageal diverticulum which attributes to several symptoms. Clinically, KJD should be differentiated from the most common type of esophageal herniation, i.e., Zenker's diverticulum (ZD). The two diverticula may present in a similar fashion, and treatments have evolved from transcervical to a minimally invasive endoscopic approach in recent years. We present a case of an 88-year-old male with symptomatic esophageal diverticulum. Barium swallow esophagogram and flexible esophagoscopy demonstrated a large KJD with food debris retention...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221152/distal-embolization-versus-combined-embolization-techniques-for-blunt-splenic-injuries-comparison-of-the-efficacy-and-complications
#12
Yon-Cheong Wong, Cheng-Hsien Wu, Li-Jen Wang, Huan-Wu Chen, Kuo-Ching Yuan, Being-Chuan Lin, Yu-Pao Hsu, Shih-Ching Kang
Comparable failure rates of distal or proximal transcatheter arterial embolization (TAE) techniques for blunt splenic injuries have been reported. This study is to investigate the efficacy and complication of combining both TAE techniques. We included 26 patients of blunt splenic injuries for TAE therapy and randomized them into distal TAE and combined TAE groups. A prospective study was performed to compare their demographics, clinical parameters, hemograms, post-TAE splenic infarct volumes, splenic abscess and pancreatitis between the two groups...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220372/the-monomeric-form-of-neisseria-dna-mimic-protein-dmp19-prevents-dna-from-binding-to-the-histone-like-hu-protein
#13
Ming-Fen Huang, Shin-Jen Lin, Tzu-Ping Ko, Yi-Ting Liao, Kai-Cheng Hsu, Hao-Ching Wang
DNA mimicry is a direct and effective strategy by which the mimic competes with DNA for the DNA binding sites on other proteins. Until now, only about a dozen proteins have been shown to function via this strategy, including the DNA mimic protein DMP19 from Neisseria meningitides. We have shown previously that DMP19 dimer prevents the operator DNA from binding to the transcription factor NHTF. Here, we provide new evidence that DMP19 monomer can also interact with the Neisseria nucleoid-associated protein HU...
2017: PloS One
https://www.readbyqxmd.com/read/29218106/extracorporeal-shock-wave-therapy-effectively-protects-brain-against-chronic-cerebral-hypo-perfusion-induced-neuropathological-changes
#14
Han-Tan Chai, Kuan-Hung Chen, Christopher Glenn Wallace, Chih-Hung Chen, Pei-Hsun Sung, Yung-Lung Chen, Chun-Man Yuen, Pei-Lin Shao, Cheuk-Kwan Sun, Hsueh-Wen Chang, Ching-Jen Wang, Mel S Lee, Hon-Kan Yip, Sheung-Fat Ko
This study tested the hypothesis that extracorporeal shock wave (ECSW) therapy could protect mouse brain from chronic cerebral hypoperfusion (CHP)-induced neuropathological changes in a bilateral carotid arterial stenosis (CAS) model. Adult-male C57BL/6 (B6) mice (n=36) were randomized into group 1 (sham-control), group 2 (CHP) and group 3 [CHP+ECSW (100 impulses at 0.15 mJ/mm2) on day 5, 10 and 15 after CHP induction]. By day 60 after CHP induction, the white matter lesion, protein expressions of inflammatory (TNF-α/NF-κB/iNOS), oxidative-stress (NOX-1/NOX-2/NOX-4/nitrotyrosine), angiogenesis (eNOS/CD31), apoptotic (Bax/caspase-3/PARP), fibrotic (Smad3/TGF-ß) and mitochondrial-damaged (cytosolic cytochrome-C) biomarkers were significantly higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1, whereas the protein expressions of anti-apoptotic (Bcl-2), anti-fibrotic (BMP-2/Smad1/5), and mitochondrial-integrity (mitochondrial cytochrome-C) biomarkers showed an opposite pattern to inflammation among the three groups (all P<0...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29216865/effect-of-orthokeratology-on-myopia-progression-twelve-year-results-of-a-retrospective-cohort-study
#15
Yueh-Chang Lee, Jen-Hung Wang, Cheng-Jen Chiu
BACKGROUND: Several studies reported the efficacy of orthokeratology for myopia control. Somehow, there is limited publication with follow-up longer than 3 years. This study aims to research whether overnight orthokeratology influences the progression rate of the manifest refractive error of myopic children in a longer follow-up period (up to 12 years). And if changes in progression rate are found, to investigate the relationship between refractive changes and different baseline factors, including refraction error, wearing age and lens replacement frequency...
December 8, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29216560/identification-of-an-oxime-containing-c-glucosylarene-as-a-potential-inhibitor-of-sodium-dependent-glucose-co-transporter-2
#16
Mao-Chia Yuan, Teng-Kuang Yeh, Chiung-Tong Chen, Jen-Shin Song, Yu-Chen Huang, Tsung-Chih Hsieh, Chung-Yu Huang, Yu-Ling Huang, Min-Hsien Wang, Szu-Huei Wu, Chun-Hsu Yao, Yu-Sheng Chao, Jinq-Chyi Lee
Treatment of hyperglycemia with drugs that block renal glucose reabsorption via inhibition of sodium-dependent glucose cotransporter 2 (SGLT2) is a novel approach to diabetes management. In this study, twenty-seven aryl C-glycosides bearing a C=N/C-N linkage at the glucosyl C6 position were designed, synthesized and evaluated for their inhibitory activity against human SGLT2 (hSGLT2). Compounds with good hSGLT2 inhibition were further investigated to determine their selectivity over hSGLT1. Of these, five representative aryl C-glycosides were chosen for pharmacokinetic analysis...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29215575/dihydrocoumarin-an-hdac-inhibitor-increases-dna-damage-sensitivity-by-inhibiting-rad52
#17
Chin-Chuan Chen, Ju-Sui Huang, Tong-Hong Wang, Chen-Hsin Kuo, Chia-Jen Wang, Shu-Huei Wang, Yann-Lii Leu
Effective DNA repair enables cancer cells to survive DNA damage induced by chemotherapeutic or radiotherapeutic treatments. Therefore, inhibiting DNA repair pathways is a promising therapeutic strategy for increasing the efficacy of such treatments. In this study, we found that dihydrocoumarin (DHC), a flavoring agent, causes deficiencies in double-stand break (DSB) repair and prolonged DNA damage checkpoint recovery in yeast. Following DNA damage, Rad52 recombinase was revealed to be inhibited by DHC, which results in deficiencies in DSB repair and prolonged DNA damage checkpoint recovery...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29214724/cme-1-a-novel-polysaccharide-suppresses-inos-expression-in-lipopolysaccharide-stimulated-macrophages-through-ceramide-initiated-protein-phosphatase-2a-activation
#18
Joen-Rong Sheu, Zhih-Cherng Chen, Ming-Jen Hsu, Shwu-Huey Wang, Kuo-Wei Jung, Wei-Fan Wu, Szu-Han Pan, Ruei-Dun Teng, Chih-Hao Yang, Cheng-Ying Hsieh
CME-1, a novel water-soluble polysaccharide purified from Ophiocordyceps sinensis mycelia, has anti-oxidative, antithrombotic and antitumour properties. In this study, other major attributes of CME-1, namely anti-inflammatory and immunomodulatory properties, were investigated. Treating lipopolysaccharide (LPS)-stimulated RAW 264.7 cells with CME-1 concentration-dependently suppressed nitric oxide formation and inducible nitric oxide synthase (iNOS) expression. In the CME-1-treated RAW 264.7 cells, LPS-induced IκBα degradation and the phosphorylation of p65, Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38, were reduced...
December 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29211811/challenges-in-the-diagnosis-of-ulcerative-colitis-with-concomitant-bacterial-infections-and-chronic-infectious-colitis
#19
Wei-Chen Lin, Chen-Wang Chang, Ming-Jen Chen, Cheng-Hsin Chu, Shou-Chuan Shih, Tzu-Chi Hsu, Horng-Yang Wang
Ulcerative colitis (UC) is a chronic inflammation of the large bowel characterized by diarrhea and a negative stool culture. However, several enteropathogens have been implicated as causative agents in UC. The differentiation between chronic infectious colitis (IC) and UC with concurrent infection is difficult owing to their similar clinical presentations. The study aimed to explore the presentations and diagnostic clues that enable differentiation between UC with concomitant infections and chronic IC. The study included 17 UC patients with a bacterial infection and 46 with chronic IC...
2017: PloS One
https://www.readbyqxmd.com/read/29209380/health-care-utilization-and-expenditures-of-patients-with-diabetes-comorbid-with-depression-disorder-a-national-population-based-cohort-study
#20
Chun-Jen Huang, Hui-Min Hsieh, Herng-Chia Chiu, Peng-Wei Wang, Mei-Hsuan Lee, Chih-Yi Li, Ching-Hua Lin
Objective: The study investigated to compare health care utilization and expenditures between diabetic patients with and without depression in Taiwan. Methods: Health care utilization and expenditure among diabetic patients with and without depression disorder during 2000 and 2004 were examined using Taiwan's population-based National Health Insurance claims database. Health care utilization included outpatient visits and the use of inpatient services, and health expenditures were outpatient, inpatient, and total medical expenditures...
November 2017: Psychiatry Investigation
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