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Jen Wang

Yu-Yen Chen, Yun-Ju Lai, Jen-Pang Wang, Ying-Cheng Shen, Chun-Yuan Wang, Hsin-Hua Chen, Hsiao-Yun Hu, Pesus Chou
BACKGROUND: Previous cross-sectional studies revealed a higher prevalence of depression among glaucoma patients. However, cohort studies were in lack to build the risk of incident depression after the diagnosis of glaucoma. The aim of our study was to investigate the association between glaucoma and the subsequent risk of developing depression and to assess risk factors associated with depression in glaucoma patients. METHODS: A population-based retrospective cohort study using the Taiwan National Health Insurance Research Database was conducted from January 1, 2001 through December 31, 2011...
June 22, 2018: BMC Ophthalmology
Yu San Chang, Yu Hsuan Wu, Chin Jen Wang, Shu Hui Tang, Hsiang Lan Chen
BACKGROUND: Cholinergic hypothesis has been advanced as an etiology of Alzheimer disease (AD) on the basis of the presynaptic deficit found in the diseased brains, and cholinesterase inhibitors (ChEIs) are the treatment of choice for these patients. However, only about half of treatment efficacy was found. Because increasing evidence supports an extensive interrelationship between thyroid hormones (THs), cortisol level and the cholinergic system, the aim of the present study was to evaluate thyroid function and cortisol level in patients with mild to moderate AD before and after ChEIs treatment, and to identify possible variations in response...
June 22, 2018: BMC Neuroscience
Akira Ijiri, Fumio Inagaki, Yusuke Kubo, Rishi R Adhikari, Shohei Hattori, Tatsuhiko Hoshino, Hiroyuki Imachi, Shinsuke Kawagucci, Yuki Morono, Yoko Ohtomo, Shuhei Ono, Sanae Sakai, Ken Takai, Tomohiro Toki, David T Wang, Marcos Y Yoshinaga, Gail L Arnold, Juichiro Ashi, David H Case, Tomas Feseker, Kai-Uwe Hinrichs, Yojiro Ikegawa, Minoru Ikehara, Jens Kallmeyer, Hidenori Kumagai, Mark A Lever, Sumito Morita, Ko-Ichi Nakamura, Yuki Nakamura, Manabu Nishizawa, Victoria J Orphan, Hans Røy, Frauke Schmidt, Atsushi Tani, Wataru Tanikawa, Takeshi Terada, Hitoshi Tomaru, Takeshi Tsuji, Urumu Tsunogai, Yasuhiko T Yamaguchi, Naohiro Yoshida
Microbial life inhabiting subseafloor sediments plays an important role in Earth's carbon cycle. However, the impact of geodynamic processes on the distributions and carbon-cycling activities of subseafloor life remains poorly constrained. We explore a submarine mud volcano of the Nankai accretionary complex by drilling down to 200 m below the summit. Stable isotopic compositions of water and carbon compounds, including clumped methane isotopologues, suggest that ~90% of methane is microbially produced at 16° to 30°C and 300 to 900 m below seafloor, corresponding to the basin bottom, where fluids in the accretionary prism are supplied via megasplay faults...
June 2018: Science Advances
Ling-Yi Wang, Shih-Fen Chen, Jen-Huai Chiang, Chung-Y Hsu, Yu-Chih Shen
OBJECTIVES: Studies have suggested a possible autoimmune contribution in a subset of patients with schizophrenia. The purpose of this study was to determine if a history of autoimmune diseases (AD) is associated with an increased risk of later onset of schizophrenia. METHODS: Taiwan's National Health Insurance Research Database was used to identify a total of 64,817 AD patients and an equal number of age-matched control patients. The incidence rates of schizophrenia with a maximum follow-up period of 10 years between patients with and without AD were compared using a Cox proportional hazard model to estimate the hazard ratio (HR) and 95% confidence interval (95% CI)...
June 17, 2018: Schizophrenia Research
Yen-Jen Wang, Tzu-Yin Tang, Jen-Yu Wang, Yen-Kai Huang, Yu-Hung Wu
BACKGROUND: Genital basal cell carcinoma (BCC) accounts for <1% of all BCCs. We aimed to elucidate the pathogenesis of genital BCC. METHODS: We retrospectively evaluated cases of pathologically diagnosed genital BCC between 1990 and 2016 in an Asian tertiary referral center. The control group was composed of consecutive cases, from 2016, of BCCs occurring in sun-exposed areas. Presence of human papillomavirus (HPV) was evaluated by polymerase chain reaction (PCR)...
June 19, 2018: Journal of Cutaneous Pathology
Kelly D Moynihan, Rebecca L Holden, Naveen K Mehta, Chensu Wang, Mark R Karver, Jens Dinter, Simon Liang, Wuhbet Abraham, Mariane B Melo, Angela Q Zhang, Na Li, Sylvie Le Gall, Bradley Pentelute, Darrell J Irvine
Antitumor T-cell responses have the potential to be curative in cancer patients, but the induction of potent T-cell immunity through vaccination remains a largely unmet goal of immunotherapy. We previously reported that the immunogenicity of peptide vaccines could be increased by maximizing delivery to lymph nodes (LNs), where T-cell responses are generated. This was achieved by conjugating the peptide to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-PEG (DSPE-PEG) to promote albumin binding, which resulted in enhanced lymphatic drainage and improved T-cell responses...
June 18, 2018: Cancer Immunology Research
Ze Wu, Xinbin Feng, Ping Li, Che-Jen Lin, Guangle Qiu, Xun Wang, Huifang Zhao, Hui Dong
Rice consumption can be a major pathway for mercury (Hg) exposure, which can cause health hazards to Chinese residents. To accurately assess the potential health risks, the bioaccessibility of Hg in rice samples collected at background and Hg-contamination sites was examined using four in vitro methods. The results showed that <50% of the total mercury (THg) was bioaccessible in the studied rice samples. The THg bioaccessibility in the rice samples collected at the Hg-contaminated site was higher than that observed at the background area...
June 2018: Journal of Environmental Sciences (China)
Brooke E E Montgomery, Paula M Frew, James P Hughes, Jing Wang, Adaora A Adimora, Danielle F Haley, Irene Kuo, Larissa Jennings, Nabila El-Bassel, Sally L Hodder
BACKGROUND: Using data from HIV Prevention Trials Network 064, a multisite, observational cohort study conducted to estimate HIV incidence rates among women living in areas of high poverty and HIV prevalence in the United States, we examined the use of HIV risk characteristics to predict emotional abuse, physical violence, and forced sex. METHODS: Participants included 2099 women, 18-44 years of age, who reported unprotected vaginal or anal sex with a male partner and an additional personal or perceived male partner HIV risk characteristic in the past 6 months...
June 15, 2018: Journal of Women's Health
Yung-Jen Cheng, Mu-Hung Tsai, Chun-Ju Chiang, Sen-Tien Tsai, Tsang-Wu Liu, Pei-Jen Lou, Chun-Ta Liao, Jin-Ching Lin, Joseph Tung-Chieh Chang, Ming-Hsui Tsai, Pen-Yuan Chu, Yi-Shing Leu, Kuo-Yang Tsai, Shyuang-Der Terng, Chih-Yen Chien, Muh-Hwa Yang, Sheng-Po Hao, Chuan-Cheng Wang, Ming-Hsun Tsai, Helen H W Chen, Chin Kuo, Yuan-Hua Wu
Conduct an accurate risk assessment of resected oral cavity squamous cell carcinoma (OSCC) patients by accessing a nationwide systemic investigation is pivotal to improve treatment outcomes. In this article, we tried to determine the impact of different prognostic factors for OSCC patients who received adjuvant radiotherapy (RT) after curative surgery, using Taiwan's national cancer registry database (TCR). A nationwide, large population-based study was conducted using TCR with patients identified from 2007 to 2015...
June 14, 2018: Cancer Medicine
Huy P Phan, Bing H Ngu, Hui-Wen Wang, Jen-Hwa Shih, Sheng-Ying Shi, Ruey-Yih Lin
Recent research has explored the nature of the theoretical concept of optimal best practice, which emphasizes the importance of personal resolve, inner strength, and the maximization of a person's development, whether it is mental, cognitive, social, or physical. In the context of academia, the study of optimal functioning places emphasis on a student's effort expenditure, positive outlook, and determination to strive for educational success and enriched subjective well-being. One major inquiry closely associated with optimal functioning is the process of optimization...
2018: PloS One
Liang-Jen Wang, Sung-Chou Li, Min-Jing Lee, Miao-Chun Chou, Wen-Jiun Chou, Sheng-Yu Lee, Chih-Wei Hsu, Lien-Hung Huang, Ho-Chang Kuo
Background: Attention-deficit/hyperactivity disorder (ADHD) is a highly genetic neurodevelopmental disorder, and its dysregulation of gene expression involves microRNAs (miRNAs). The purpose of this study was to identify potential miRNAs biomarkers and then use these biomarkers to establish a diagnostic panel for ADHD. Design and methods: RNA samples from white blood cells (WBCs) of five ADHD patients and five healthy controls were combined to create one pooled patient library and one control library. We identified 20 candidate miRNAs with the next-generation sequencing (NGS) technique (Illumina)...
2018: Frontiers in Psychiatry
Min-Jing Lee, Miao-Chun Chou, Wen-Jiun Chou, Chien-Wei Huang, Ho-Chang Kuo, Sheng-Yu Lee, Liang-Jen Wang
Background: Heavy metals are known to be harmful for neurodevelopment and they may correlate to attention deficit/hyperactivity disorder (ADHD). In this study, we aim to explore the relationships between multiple heavy metals (manganese, lead, cadmium, mercury, antimony, and bismuth), neurocognitive function, and ADHD symptoms. Methods: We recruited 29 patients with ADHD inattentive type (ADHD-I), 47 patients with ADHD hyperactivity/impulsivity type (ADHD-H/I), and 46 healthy control children. Urine samples were obtained to measure the levels of the aforementioned heavy metals in each child...
June 10, 2018: International Journal of Environmental Research and Public Health
Archana S Nagaraja, Robert L Dood, Guillermo Armaiz-Pena, Yu Kang, Sherry Y Wu, Julie K Allen, Nicholas B Jennings, Lingegowda S Mangala, Sunila Pradeep, Yasmin Lyons, Monika Haemmerle, Kshipra M Gharpure, Nouara C Sadaoui, Cristian Rodriguez-Aguayo, Cristina Ivan, Ying Wang, Keith Baggerly, Prahlad Ram, Gabriel Lopez-Berestein, Jinsong Liu, Samuel C Mok, Lorenzo Cohen, Susan K Lutgendorf, Steve W Cole, Anil K Sood
No abstract text is available yet for this article.
June 7, 2018: JCI Insight
Chih-Wei Hsu, Liang-Jen Wang, Pao-Yen Lin
BACKGROUND: While previous studies have investigated the effect of repetitive transcranial magnetic stimulation (rTMS) in treating Tourette syndrome (TS), the results remain inconclusive. OBJECTIVE: We aim to systematically review the existing literature related to the efficacy of rTMS in TS and synthesize the results through meta-analysis. METHODS: We searched for PubMed, Embase, Cochrane Library, and databases without language restriction through January 1, 2018, and included randomized-controlled and open-label trials that assessed the treatment effect of rTMS for tic symptoms...
June 5, 2018: Brain Stimulation
Yuan Chi Shen, Hung Jen Wang, Yao Chi Chuang
PURPOSE: Mirabegron is a relatively new drug to treat overactive bladder (OAB). The therapeutic doses are between 25 and 100 mg in clinical trials. We aimed to evaluate the efficacy and persistence of low-dose mirabegron (25 mg) in patients with OAB in daily urological practice. METHODS: The study was a retrospective consecutive cohort of 177 OAB patients (101 male and 76 female) treated with 25 mg of mirabegron mg since January 2016 to November 2016. The therapeutic outcomes were assessed at baseline, 4, 12, and 24 weeks...
June 7, 2018: International Urology and Nephrology
Jenn-Haung Lai, Mei-Yi Wang, Chuan-Yueh Huang, Chien-Hsiang Wu, Li-Feng Hung, Chia-Ying Yang, Po-Yuan Ke, Shue-Fen Luo, Shih-Jen Liu, Ling-Jun Ho
Toll-like receptors (TLRs) are important sensors that recognize pathogen-associated molecular patterns. Generally, TLR9 is known to recognize bacterial or viral DNA but not viral RNA and initiate an immune response. Herein, we demonstrate that infection with dengue virus (DENV), an RNA virus, activates TLR9 in human dendritic cells (DCs). DENV infection induces release of mitochondrial DNA (mtDNA) into the cytosol and activates TLR9 signaling pathways, leading to production of interferons (IFNs). The DENV-induced mtDNA release involves reactive oxygen species generation and inflammasome activation...
June 7, 2018: EMBO Reports
Hsuan Su, Lulu Huang, Chien-Min Han, Yu-Jen Lin, Chih-Feng Yen, Chyi-Long Lee, Chin-Jung Wang
OBJECTIVE: Hysterectomy via transvaginal natural orifice transluminal endoscopic surgery (NOTES) has been carried out for benign uterine diseases and nonprolapsed uteri in recent years. Subtotal hysterectomy was performed to remove the uterus with preservation of the cervix by abdominal, laparoscopic, or vaginal routes. The aim of this retrospective study is to gain insight into the feasibility and safety of subtotal hysterectomy through transvaginal NOTES. MATERIALS AND METHODS: This is the first case series study to describe the technique and to evaluate the feasibility of this innovative surgical procedure...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
Yu-Hsien Lai, Chih-Hsien Wang, Jen-Pi Tsai, Jia-Sian Hou, Chung-Jen Lee, Bang-Gee Hsu
Objective: Peripheral artery disease (PAD) is associated with systemic atherosclerosis and indicates an increased risk of mortality in peritoneal dialysis (PD) patients. A high leptin level accelerates atherosclerosis in apoE-deficient mice. The purpose of this study was to examine the association of serum leptin level and PAD in adult PD patients. Materials and Methods: The clinical characteristics of sixty PD patients recruited from June 2015 to October 2016 were obtained...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Yuan-Hsi Wang, Yuh-Ching Twu, Chung-Kwe Wang, Fu-Zhen Lin, Chun-Ya Lee, Yi-Jen Liao
Liver fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. A high-cholesterol diet is associated with liver fibrosis via the accumulation of free cholesterol in hepatic stellate cells (HSCs). Niemann-Pick type C2 (NPC2) plays an important role in the regulation of intracellular free cholesterol homeostasis via direct binding with free cholesterol. Previously, we reported that NPC2 was downregulated in liver cirrhosis tissues. Loss of NPC2 enhanced the accumulation of free cholesterol in HSCs and made them more susceptible to transforming growth factor (TGF)-β1...
June 5, 2018: International Journal of Molecular Sciences
Ching-Wei Chang, Chia-Yuan Liu, Hung-Chang Lee, Yen-Hua Huang, Li-Hui Li, Jen-Shiu Chiang Chiau, Tsang-En Wang, Cheng-Hsin Chu, Shou-Chuan Shih, Tung-Hu Tsai, Yu-Jen Chen
Adjuvant 5-fluorouracil (5-FU)-based chemotherapy, including FOLFOX (5-FU, leucovorin, and oxaliplatin), is recommended for colorectal cancer. However, intestinal mucositis remains a common adverse effect for which no effective preventive strategies are available. To develop a convenient and novel way to alleviate mucositis, we investigated the effect of Lactobacillus casei variety rhamnosus ( Lcr35 ) on FOLFOX-induced mucosal injury. BALB/c mice subcutaneously injected with syngeneic CT26 colorectal adenocarcinoma cells were orally administered Lcr35 daily before, during, and after 5-day injection of FOLFOX regimen, for 14 days...
2018: Frontiers in Microbiology
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