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https://www.readbyqxmd.com/read/29454350/application-of-four-dimension-criteria-to-assess-rigour-of-qualitative-research-in-emergency-medicine
#1
Roberto Forero, Shizar Nahidi, Josephine De Costa, Mohammed Mohsin, Gerry Fitzgerald, Nick Gibson, Sally McCarthy, Patrick Aboagye-Sarfo
BACKGROUND: The main objective of this methodological manuscript was to illustrate the role of using qualitative research in emergency settings. We outline rigorous criteria applied to a qualitative study assessing perceptions and experiences of staff working in Australian emergency departments. METHODS: We used an integrated mixed-methodology framework to identify different perspectives and experiences of emergency department staff during the implementation of a time target government policy...
February 17, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29452941/surgical-site-infection-after-gastrointestinal-surgery-in-high-income-middle-income-and-low-income-countries-a-prospective-international-multicentre-cohort-study
#2
(no author information available yet)
BACKGROUND: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. METHODS: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country...
February 13, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29452522/the-evolution-of-clinical-trials-can-we-address-the-challenges-of-the-future
#3
Hans-Georg Eichler, Fergus Sweeney
The authors describe key challenges facing the clinical trials community and propose solutions to these issues, including the role the Clinical Trials Transformation Initiative can play in addressing these issues. Specifically, the authors reflect on clinical trial globalization and the harmonization of frameworks and requirements across regions; the challenges associated with balancing the desire for external validity, pragmatic trials, and precision medicine; clinical trial transparency; and operational complexity and the expense of clinical trials...
February 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29452444/risk-of-venous-thrombosis-in-antithrombin-deficiency-a-systematic-review-and-bayesian-meta-analysis
#4
F Nanne Croles, Jaime Borjas-Howard, Kazem Nasserinejad, Frank W G Leebeek, Karina Meijer
Antithrombin deficiency is a strong risk factor for venous thromboembolism (VTE), but the absolute risk of the first and recurrent VTE is unclear. The objective of this paper is to establish the absolute risks of the first and recurrent VTE and mortality in individuals with antithrombin deficiency. The databases Embase, Medline Ovid, Web of Science, the Cochrane Library, and Google Scholar were systematically searched for case-control and cohort studies. Bayesian random-effects meta-analysis was used to calculate odds ratios (ORs), absolute risks, and probabilities of ORs being above thresholds...
February 16, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29452082/pre-treatment-red-blood-cell-distribution-width-provides-prognostic-information-in-multiple-myeloma
#5
Di Zhou, Peipei Xu, Miaoxin Peng, Xiaoyan Shao, Miao Wang, Jian Ouyang, Bing Chen
BACKGROUND: The red blood cell distribution width (RDW), a credible marker for abnormal erythropoiesis, has recently been studied as a prognostic factor in oncology, but its role in multiple myeloma (MM) hasn't been thoroughly investigated. METHODS: We performed a retrospective study in 162 patients with multiple myeloma. Categorical parameters were analyzed using Pearson chi-squared test. The Mann-Whitney and Wilcoxon tests were used for group comparisons. Comparisons of repeated samples data were analyzed with the general linear model repeated-measures procedure...
February 13, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29450027/faculty-development-through-simulation-based-education-in-physical-therapist-education
#6
Kristin Curry Greenwood, Sara B Ewell
Background: The use of simulation-based education (SBE) in health professions, such as physical therapy, requires faculty to expand their teaching practice and development. The impact of this teaching on the individual faculty member, and how their teaching process changes or develops, is not fully understood. The purpose of this study was to explore individual physical therapist faculty members' experience with SBE and how those experiences may have transformed their teaching practice to answer the research questions: How do physical therapist faculty develop through including SBE and are there commonalities among educators? Methods: An interpretive phenomenological analysis approach was used with a small sample of subjects who participated in three individual semi-structured interviews...
2018: Advances in Simulation
https://www.readbyqxmd.com/read/29449041/biomechanical-simulation-of-traumatic-brain-injury-in-the-rat
#7
REVIEW
John D Finan
BACKGROUND: Traumatic brain injury poses an enormous clinical challenge. Rats are the animals most widely used in pre-clinical experiments. Biomechanical simulations of these experiments predict the distribution of mechanical stress and strain across key tissues. It is in theory possible to dramatically increase our understanding of traumatic brain injury pathophysiology by correlating stress and strain with histological and functional injury outcomes. This review summarizes the state of the art in biomechanical simulation of traumatic brain injury in the rat...
January 31, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29448125/a-critical-review-of-histopathological-findings-associated-with-endocrine-and-non-endocrine-hepatic-toxicity-in-fish-models
#8
REVIEW
Jeffrey C Wolf, James R Wheeler
Although frequently examined as a target organ for non-endocrine toxicity, histopathological evaluation of the liver is becoming a routine component of endocrine disruption studies that utilize various fish species as test subjects. However, the interpretation of microscopic liver findings can be challenging, especially when attempting to distinguish adverse changes associated with endocrine disrupting substances from those caused by systemic or direct hepatic toxicity. The purpose of this project was to conduct a critical assessment of the available peer-reviewed and grey literature concerning the histopathologic effects of reproductive endocrine active substances (EAS) and non-endocrine acting substances in the livers of fish models, and to determine if liver histopathology can be used to reliably distinguish endocrine from non-endocrine etiologies...
February 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29445300/gastric-cancer-epidemiology-prevention-classification-and-treatment
#9
REVIEW
Robert Sitarz, Małgorzata Skierucha, Jerzy Mielko, G Johan A Offerhaus, Ryszard Maciejewski, Wojciech P Polkowski
Gastric cancer is the second most common cause of cancer-related deaths in the world, the epidemiology of which has changed within last decades. A trend of steady decline in gastric cancer incidence rates is the effect of the increased standards of hygiene, conscious nutrition, and Helicobacter pylori eradication, which together constitute primary prevention. Avoidance of gastric cancer remains a priority. However, patients with higher risk should be screened for early detection and chemoprevention. Surgical resection enhanced by standardized lymphadenectomy remains the gold standard in gastric cancer therapy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29442277/exploring-lactation-consultant-views-on-infant-safe-sleep
#10
Nichole L Hodges, Lara B McKenzie, Sarah E Anderson, Mira L Katz
Objectives The purpose of this qualitative study was to explore the infant safe sleep beliefs and occupational practices of lactation consultants and to determine if lactation consultants give advice to clients that is consistent with the American Academy of Pediatrics' recommendations on this topic. Methods Focus groups were conducted with certified lactation consultants in two cities in Ohio. Participants discussed the role of lactation consultants, the infant sleep advice they provide to women, their views on the American Academy of Pediatrics' infant safe sleep recommendations and related policies, and perceived benefits and barriers associated with providing infant safe sleep education as part of their work...
February 13, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29442226/molecular-evolution-and-phylodynamics-of-hepatitis-b-virus-infection-circulating-in-iran
#11
Sayed-Hamidreza Mozhgani, Seyed Amir Malekpour, Mehdi Norouzi, Fatemeh Ramezani, Seyed Abdolrahim Rezaee, Vahdat Poortahmasebi, Mehdi Sadeghi, Seyed Moayed Alavian, Mohadeseh Zarei-Ghobadi, Azam Ghaziasadi, Hadi Karimzadeh, Reza Malekzadeh, Masood Ziaee, Farshid Abedi, Behrooz Ataei, Majid Yaran, Babak Sayad, Hamid Reza Jahantigh, Mohammad Hossein Somi, Gholamreza Sarizadeh, Ismail Sanei-Moghaddam, Fariborz Mansour-Ghanaei, Hossein Keyvani, Ebrahim Kalantari, Zahra Fakhari, Babak Geravand, Seyed Mohammad Jazayeri
Previous local and national Iranian publications indicate that all Iranian hepatitis B virus (HBV) strains belong to HBV genotype D. The aim of this study was to analyze the evolutionary history of HBV infection in Iran for the first time, based on an intensive phylodynamic study. The evolutionary parameters, time to most recent common ancestor (tMRCA), and the population dynamics of infections were investigated using the Bayesian Monte Carlo Markov chain (BMCMC). The effective sample size (ESS) and sampling convergence were then monitored...
February 13, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29441567/water-fluoridation-and-the-quality-of-information-available-online
#12
Zachary Frangos, Maryke Steffens, Julie Leask
BACKGROUND: The Internet has transformed the way in which people approach their health care, with online resources becoming a primary source of health information. Little work has assessed the quality of online information regarding community water fluoridation. This study sought to assess the information available to individuals searching online for information, with emphasis on the credibility and quality of websites. METHODS: We identified the top 10 web pages returned from different search engines, using common fluoridation search terms (identified in Google Trends)...
February 13, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29441507/economic-evaluation-of-fulvestrant-500-mg-compared-to-generic-aromatase-inhibitors-in-patients-with-advanced-breast-cancer-in-sweden
#13
Ugne Sabale, Mattias Ekman, Daniel Thunström, Claire Telford, Christopher Livings
OBJECTIVES: In Sweden, breast cancer (BC) represents 30% of newly diagnosed cancers and is the most common cancer in women. For hormone-dependent BC, endocrine therapies varying in efficacy and price are available. The aim of this study is to assess the cost effectiveness of fulvestrant 500 mg as a second-line hormonal therapy for postmenopausal women with estrogen receptor-positive metastatic or locally advanced BC versus letrozole, anastrozole, and exemestane in Sweden. METHODS: A three-state (pre-progression, post-progression, and death) partitioned-survival model was used to estimate progression-free (PFS) and overall survival (OS) by extrapolating trial results beyond the trial period to capture costs and benefits over a lifetime perspective...
December 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29440670/characterization-of-conserved-and-novel-micrornas-in-lilium-lancifolium-thunb-by-high-throughput-sequencing
#14
Xiangfeng He, Awraris Getachew Shenkute, Wenhe Wang, Shufa Xu
MicroRNAs (miRNAs) are among the class of noncoding small RNA molecules and play a crucial role in post-transcriptional regulation in plants. Although Lilium is one of the most popular ornamental flowers worldwide, however, there is no report on miRNAs identification. In the present study, therefore, miRNAs and their targets were identified from flower, leaf, bulblet and bulb of Lilium lancifolium Thunb. by high-throughput sequencing and bioinformatics analysis. In this study, a total of 38 conserved miRNAs belonging to 17 miRNA families and 44 novel miRNAs were identified...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439321/knowledge-attitude-and-practice-of-hiv-aids-among-workers-at-china-first-highway-engineering-company-at-bilibila-sokota-road-project-sokota-ethiopia
#15
Mebratu Tarekegne, Addis Adera, Kalab Haile, Derara Guyo
OBJECTIVE: The aim of this study was to assess Bilbila Sokota Road Project workers' knowledge, attitude and practice on HIV/AIDS in China first highway engineering Company. METHODS: A cross sectional Survey was conducted among workers in China first high way engineering Company at Bilbila Sokota road project, Sokota, Ethiopia. Fifty-five workers were taken from project site/company. Data was collected using a validated self-administrated standardized questionnaire on Knowledge, attitude and practice including behavioral change regarding HIV/AIDS...
February 5, 2018: Human Antibodies
https://www.readbyqxmd.com/read/29438454/comparative-efficacy-of-antihypertensive-agents-in-salt-sensitive-hypertensive-patients-a-network-meta-analysis
#16
Han Qi, Zheng Liu, Han Cao, Wei-Ping Sun, Wen-Juan Peng, Bin Liu, Sheng-Jie Dong, Yu-Tao Xiang, Ling Zhang
Background: Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential hypertension as well as being an independent risk factor for cardiovascular disease. However, effective medications for the treatment of SSH have not been clarified. This study was to compare the efficacious of different classes of antihypertensive agents combined with salt intake on the reduction of blood pressure in patients with salt-sensitive hypertension (SSH). Methods: We used sources as PubMed, EMBASE, Cochrane Library, CENTRAL, ClinicalTrials...
February 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29434018/medical-youtube-videos-and-methods-of-evaluation-literature-review
#17
REVIEW
Brandy Drozd, Emily Couvillon, Andrea Suarez
BACKGROUND: Online medical education has relevance to public health literacy and physician efficacy, yet it requires a certain standard of reliability. While the internet has the potential to be a viable medical education tool, the viewer must be able to discern which information is reliable. OBJECTIVE: Our aim was to perform a literature review to determine and compare the various methods used when analyzing YouTube videos for patient education efficacy, information accuracy, and quality...
February 12, 2018: JMIR Medical Education
https://www.readbyqxmd.com/read/29434017/health-information-obtained-from-the-internet-and-changes-in-medical-decision-making-questionnaire-development-and-cross-sectional-survey
#18
Yen-Yuan Chen, Chia-Ming Li, Jyh-Chong Liang, Chin-Chung Tsai
BACKGROUND: The increasing utilization of the internet has provided a better opportunity for people to search online for health information, which was not easily available to them in the past. Studies reported that searching on the internet for health information may potentially influence an individual's decision making to change her health-seeking behaviors. OBJECTIVE: The objectives of this study were to (1) develop and validate 2 questionnaires to estimate the strategies of problem-solving in medicine and utilization of online health information, (2) determine the association between searching online for health information and utilization of online health information, and (3) determine the association between online medical help-seeking and utilization of online health information...
February 12, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29433821/a-method-for-screening-active-components-from-chinese-herbs-by-cell-membrane-chromatography-offline-high-performance-liquid-chromatography-mass-spectrometry-and-an-online-statistical-tool-for-data-processing
#19
Yan Cao, Shaozhan Wang, Yinghua Li, Xiaofei Chen, Langdong Chen, Dongyao Wang, Zhenyu Zhu, Yongfang Yuan, Diya Lv
Cell membrane chromatography (CMC) has been successfully applied to screen bioactive compounds from Chinese herbs for many years, and some offline and online two-dimensional (2D) CMC-high performance liquid chromatography (HPLC) hyphenated systems have been established to perform screening assays. However, the requirement of sample preparation steps for the second-dimensional analysis in offline systems and the need for an interface device and technical expertise in the online system limit their extensive use...
February 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29433666/similarities-and-differences-in-child-development-from-birth-to-age-3-years-by-sex-and-across-four-countries-a-cross-sectional-observational-study
#20
Ilgi Ozturk Ertem, Vibha Krishnamurthy, Mphelekedzeni C Mulaudzi, Yanina Sguassero, Hakan Balta, Ozlem Gulumser, Burcu Bilik, Roopa Srinivasan, Benjamin Johnson, Geliang Gan, Lisa Calvocoressi, Veronika Shabanova, Brian W C Forsyth
BACKGROUND: Knowledge about typical development is of fundamental importance for understanding and promoting child health and development. We aimed to ascertain when healthy children in four culturally and linguistically different countries attain developmental milestones and to identify similarities and differences across sexes and countries. METHODS: In this cross-sectional, observational study, we recruited children aged 0-42 months and their caregivers between March 3, 2011, and May 18, 2015, at 22 health clinics in Argentina, India, South Africa, and Turkey...
March 2018: Lancet Global Health
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