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https://www.readbyqxmd.com/read/28723663/a-network-meta-analysis-on-the-efficacy-of-targeted-agents-in-combination-with-chemotherapy-for-treatment-of-advanced-metastatic-triple-negative-breast-cancer
#1
Long Ge, Yan Tang, Qiu-Ning Zhang, Jin-Hui Tian, Xiao-Hu Wang, Dawid Pieper, Bei Pan, Lun Li, Juan Ling, Zhi-Tong Bing, Ke-Hu Yang
OBJECTIVE: Our network meta-analysis aimed to determine the assistant efficacy of targeted therapy in combined with chemotherapy for advanced/metastatic triple-negative breast cancer (TNBC). RESULTS: A total of 15 randomized controlled trials (RCTs), involving 2,410 patients, met our inclusion criteria. Eight targeted agents involving 11 treatment arms were included. The methodological quality of included RCTs was acceptable. The results of direct comparisons showed that progression-free survival (PFS) was significantly longer with bevacizumab+chemotherapy when compared to chemotherapy alone (hazard ratio [HR] = 0...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28721020/access-to-credible-information-on-schizophrenia-patients-medication-adherence-by-prescribers-can-change-their-treatment-strategies-evidence-from-an-online-survey-of-providers
#2
Jason Shafrin, Suepattra G May, Anshu Shrestha, Charles Ruetsch, Nicole Gerlanc, Felicia Forma, Ainslie Hatch, Darius N Lakdawalla, Jean-Pierre Lindenmayer
OBJECTIVE: Overestimating patients' medication adherence diminishes the ability of psychiatric care providers to prescribe the most effective treatment and to identify the root causes of treatment resistance in schizophrenia. This study was conducted to determine how credible patient drug adherence information (PDAI) might change prescribers' treatment decisions. METHODS: In an online survey containing 8 clinical case vignettes describing patients with schizophrenia, health care practitioners who prescribe antipsychotics to patients with schizophrenia were instructed to choose a preferred treatment recommendation from a set of predefined pharmacologic and non-pharmacologic options...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28719783/making-sense-of-studies-that-claim-benefits-of-frenotomy-in-the-absence-of-classic-tongue-tie
#3
Pamela Douglas
By performing an in-depth analysis of one high profile example, this article aims to help breastfeeding support professionals understand the methodological flaws that characterize recent studies claiming to show the efficacy of frenotomy for the diagnoses of posterior tongue-tie and upper lip-tie. The example study does not address definitional confusion or control for the effects of the passage of time. It does not consider the effects of caring attention, validation, and lactation consultant support. It also does not consider the extensive research over the past three decades that has established that reflux in the first 6 months of life is benign, even though increased reflux frequency may correlate with unsettled infant behavior...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28719276/high-hepatitis-e-seroprevalence-among-displaced-persons-in-south-sudan
#4
Andrew S Azman, Malika Bouhenia, Anita S Iyer, John Rumunu, Richard Lino Laku, Joseph F Wamala, Isabel Rodriguez-Barraquer, Justin Lessler, Etienne Gignoux, Francisco J Luquero, Daniel T Leung, Emily S Gurley, Iza Ciglenecki
AbstractLarge protracted outbreaks of hepatitis E virus (HEV) have been documented in displaced populations in Africa over the past decade though data are limited outside these exceptional settings. Serological studies can provide insights useful for improving surveillance and disease control. We conducted an age-stratified serological survey using samples previously collected for another research study from 206 residents of an internally displaced person camp in Juba, South Sudan. We tested serum for anti-HEV antibodies (IgM and IgG) and estimated the prevalence of recent and historical exposure to the virus...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718015/capable-and-credible-challenging-nutrition-science
#5
EDITORIAL
Bart Penders, Anna Wolters, Edith F Feskens, Fred Brouns, Machteld Huber, Els L M Maeckelberghe, Gerjan Navis, Theo Ockhuizen, Jogchum Plat, Jan Sikkema, Marianne Stasse-Wolthuis, Pieter van 't Veer, Marcel Verweij, Jan de Vries
Nutrition science has enriched our understanding of how to stay healthy by producing valuable knowledge about the interaction of nutrients, food, and the human body. Nutrition science also has raised societal awareness about the links between food consumption and well-being, and provided the basis for food regulations and dietary guidelines. Its collaborative and interdisciplinary research has accomplished much, scientifically and socially. Despite this, nutrition science appears to be in crisis and is currently confronted with a public reluctance to trust nutritional insights...
July 17, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28717987/interventions-for-refractory-trigeminal-neuralgia-a-bayesian-mixed-treatment-comparison-network-meta-analysis-of-randomized-controlled-clinical-trials
#6
Kannan Sridharan, Gowri Sivaramakrishnan
INTRODUCTION: Patients with trigeminal neuralgia (TN) are often refractory to recommended first-line agents. Due to the absence of a systematic review, we undertook a network meta-analysis to assess various interventions that can be used to manage refractory TN. METHODS: Electronic databases were searched using appropriate strategies to identify randomized controlled clinical trials in patients with refractory TN, evaluating the proportion of patients with a minimum of 50% reduction in pain or a minimum of 2 cm reduction in score in an appropriate pain scale or complete pain relief by subjective pain scales...
July 17, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28714733/keep-your-bias-to-yourself-how-deliberating-with-differently-biased-others-affects-mock-jurors-guilt-decisions-perceptions-of-the-defendant-memories-and-evidence-interpretation
#7
Christine L Ruva, Christina C Guenther
This experiment explored how mock-jurors' (N = 648) guilt decisions, perceptions of the defendant, memories, and evidence interpretation varied as a function of jury type and pretrial publicity (PTP); utilizing a 2 (jury type: pure-PTP vs. mixed-PTP) × 3 (PTP: defendant, victim, and irrelevant) factorial design. Mock-juries (N = 126) were composed of jurors exposed to the same type of PTP (pure-PTP; e.g., defendant-PTP) or different types of PTP (mixed-PTP; e.g., half exposed to defendant-PTP and half to irrelevant-PTP)...
July 17, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/28712616/aripiprazole-lauroxil-compared-with-paliperidone-palmitate-in-patients-with-schizophrenia-an-indirect-treatment-comparison
#8
Chris Cameron, Jacqueline Zummo, Dharmik N Desai, Christine Drake, Brian Hutton, Ahmed Kotb, Peter J Weiden
BACKGROUND: Aripiprazole lauroxil (AL) is a long-acting injectable atypical antipsychotic recently approved for treatment of schizophrenia on the basis of a large-scale trial of two doses of AL versus placebo. There are no direct-comparison studies with paliperidone palmitate (PP; long-acting antipsychotic used most often in acute settings) for the acute psychotic episode. OBJECTIVES: To indirectly compare efficacy and safety of the pivotal AL study with all PP studies meeting indirect comparison criteria...
July 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28710926/speech-and-language-therapy-service-delivery-overcoming-limited-provision-for-children
#9
L M T Jesus, J Martinez, A R Valente, M C Costa
OBJECTIVES: To test an alternative Speech and Language Therapy (SLT) service delivery model based on partnerships between a University and local schools and charities, and to report on the impact and feasibility of intervention based on long-term outcome measures and three case studies with individual analysis of Reliable Change. STUDY DESIGN: The following six-step model was tested: 1-establishing partnerships; 2-flagging children; 3-pre-treatment SLT assessment; 4-reporting and discussion with parents and teachers; 5-treatment; 6-post-treatment assessment...
July 12, 2017: Public Health
https://www.readbyqxmd.com/read/28710065/the-limitations-of-using-randomised-controlled-trials-as-a-basis-for-developing-treatment-guidelines
#10
REVIEW
Roger Mulder, Ajeet B Singh, Amber Hamilton, Pritha Das, Tim Outhred, Grace Morris, Darryl Bassett, Bernhard T Baune, Michael Berk, Philip Boyce, Bill Lyndon, Gordon Parker, Gin S Malhi
Randomised controlled trials (RCTs) are considered the 'gold standard' by which novel psychotropic medications and psychological interventions are evaluated and consequently adopted into widespread clinical practice. However, there are some limitations to using RCTs as the basis for developing treatment guidelines. While RCTs allow researchers to determine whether a given medication or intervention is effective in a specific patient sample, for practicing clinicians it is more important to know whether it will work for their particular patient in their particular setting...
July 14, 2017: Evidence-based Mental Health
https://www.readbyqxmd.com/read/28709110/a-full-bayesian-approach-to-appraise-the-safety-effects-of-pedestrian-countdown-signals-to-drivers
#11
Angela E Kitali, P E Thobias Sando
Although they are meant for pedestrians, pedestrian countdown signals (PCSs) give cues to drivers about the length of the remaining green phase, hence affecting drivers' behavior at intersections. This study focuses on the evaluation of the safety effectiveness of PCSs to drivers, in the cities of Jacksonville and Gainesville, Florida, using crash modification factors (CMFs) and crash modification functions (CMFunctions). A full Bayes (FB) before-and-after with comparison group method was used to quantify the safety impacts of PCSs to drivers...
July 11, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28707643/assessing-reading-levels-of-health-information-uses-and-limitations-of-flesch-formula
#12
Pranay Jindal, Joy C MacDermid
BACKGROUND: Written health information is commonly used by health-care professionals (HCPs) to inform and assess patients in clinical practice. With growing self-management of many health conditions and increased information seeking behavior among patients, there is a greater stress on HCPs and researchers to develop and implement readable and understandable health information. Readability formulas such as Flesch Reading Ease (FRE) and Flesch-Kincaid Reading Grade Level (FKRGL) are commonly used by researchers and HCPs to assess if health information is reading grade appropriate for patients...
January 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28705591/effectiveness-of-surgery-versus-conservative-treatment-for-lumbar-spinal-stenosis-a-system-review-and-meta-analysis-of-randomized-controlled-trials
#13
REVIEW
Xin-Long Ma, Xing-Wen Zhao, Jian-Xiong Ma, Fei Li, Yin Wang, Bin Lu
PURPOSE: Lumbar spinal stenosis (LSS) was a common degenerative disease that affected the lumbar spine function and quality of life, which can be treated both surgery and conservative treatment. We did this study to compare the effectiveness of surgery versus conservative treatment for LSS. METHODS: We searched PubMed as well as other databases in September.18th.2016. Randomized controlled trials compared surgery versus conservative treatment for patients with LSS were enrolled...
July 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28702874/towards-a-transparent-credible-evidence-based-decision-making-process-of-new-drug-listing-on-the-hong-kong-hospital-authority-drug-formulary-challenges-and-suggestions
#14
Carlos King Ho Wong, Olivia Wu, Bernard M Y Cheung
The aim of this article is to describe the process, evaluation criteria, and possible outcomes of decision-making for new drugs listed in the Hong Kong Hospital Authority Drug Formulary in comparison to the health technology assessment (HTA) policy overseas. Details of decision-making processes including the new drug listing submission, Drug Advisory Committee (DAC) meeting, and procedures prior to and following the meeting, were extracted from the official Hong Kong Hospital Authority drug formulary management website and manual...
July 12, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28702046/selection-and-validation-of-appropriate-reference-genes-for-qrt-pcr-analysis-in-isatis-indigotica-fort
#15
Tao Li, Jing Wang, Miao Lu, Tianyi Zhang, Xinyun Qu, Zhezhi Wang
Due to its sensitivity and specificity, real-time quantitative PCR (qRT-PCR) is a popular technique for investigating gene expression levels in plants. Based on the Minimum Information for Publication of Real-Time Quantitative PCR Experiments (MIQE) guidelines, it is necessary to select and validate putative appropriate reference genes for qRT-PCR normalization. In the current study, three algorithms, geNorm, NormFinder, and BestKeeper, were applied to assess the expression stability of 10 candidate reference genes across five different tissues and three different abiotic stresses in Isatis indigotica Fort...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28700715/the-pharmacological-and-non-pharmacological-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-systematic-review-with-network-meta-analyses-of-randomised-trials
#16
Ferrán Catalá-López, Brian Hutton, Amparo Núñez-Beltrán, Matthew J Page, Manuel Ridao, Diego Macías Saint-Gerons, Miguel A Catalá, Rafael Tabarés-Seisdedos, David Moher
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed psychiatric disorders in childhood. A wide variety of treatments have been used for the management of ADHD. We aimed to compare the efficacy and safety of pharmacological, psychological and complementary and alternative medicine interventions for the treatment of ADHD in children and adolescents. METHODS AND FINDINGS: We performed a systematic review with network meta-analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28699595/effectiveness-of-non-steroidal-anti-inflammatory-drugs-for-the-treatment-of-pain-in-knee-and-hip-osteoarthritis-a-network-meta-analysis
#17
Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are the backbone of osteoarthritis pain management. We aimed to assess the effectiveness of different preparations and doses of NSAIDs on osteoarthritis pain in a network meta-analysis. METHODS: For this network meta-analysis, we considered randomised trials comparing any of the following interventions: NSAIDs, paracetamol, or placebo, for the treatment of osteoarthritis pain. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) and the reference lists of relevant articles for trials published between Jan 1, 1980, and Feb 24, 2015, with at least 100 patients per group...
July 8, 2017: Lancet
https://www.readbyqxmd.com/read/28698975/exploring-the-impact-of-feedback-on-prescribing-error-rates-a-pilot-study
#18
Michael Lloyd, Simon David Watmough, Sarah Victoria O'Brien, Kevin Hardy, Niall Furlong
Background Prescribing errors are prevalent in hospital settings with feedback identified as one potential error reduction strategy. Hospital pharmacists work alongside prescribers at ward level and are credible facilitators of prescribing error feedback. A formalised programme of pharmacist-led prescribing error feedback was designed and implemented Objective To determine the impact of the feedback intervention on prescribing error rates. Method Prospective prescribing audits were undertaken at baseline for control (n = 11) and intervention group (n = 10) prescribers...
July 11, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28697389/interaction-patterns-and-toxicities-of-binary-and-ternary-pesticide-mixtures-to-daphnia-magna-estimated-by-an-accelerated-failure-time-model
#19
Xuchun Qiu, Wataru Tanoue, Atsushi Kawaguchi, Takashi Yanagawa, Masanori Seki, Yohei Shimasaki, Tsuneo Honjo, Yuji Oshima
Organisms in natural environments are often exposed to a broad variety of chemicals, and the multi-chemical mixtures exposure may produce significant toxic effects, even though the individual chemicals are present at concentrations below their no-observed-effect concentrations. This study represents the first attempt that uses the accelerated failure time (AFT) model to quantify the interaction and toxicity of multi-chemical mixtures in environmental toxicology. We firstly conducted the acute immobilization tests with Daphnia magna exposed to mixtures of diazinon (DZN), fenitrothion (MEP); and thiobencarb (TB) in single, binary, and ternary formulations, and then fitted the results to the AFT model...
July 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28695999/to-be-certain-about-the-uncertainty-bayesian-statistics-for-13-c-metabolic-flux-analysis
#20
Axel Theorell, Samuel Leweke, Wolfgang Wiechert, Katharina Nöh
(13) C Metabolic Fluxes Analysis ((13) C MFA) remains to be the most powerful approach to determine intracellular metabolic reaction rates. Decisions on strain engineering and experimentation heavily rely upon the certainty with which these fluxes are estimated. For uncertainty quantification, the vast majority of (13) C MFA studies relies on confidence intervals from the paradigm of Frequentist statistics. However, it is well known that the confidence intervals for a given experimental outcome are not uniquely defined...
July 11, 2017: Biotechnology and Bioengineering
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