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https://www.readbyqxmd.com/read/29468166/suspicion-of-postanesthetic-femoral-paralysis-of-the-non-dependent-limb-in-a-horse
#1
Alessandro Mirra, Micaël David Klopfenstein Bregger, Olivier Louis Levionnois
A 15-year-old Selle Francais gelding was presented to the equine referral hospital for treatment of a left guttural pouch mycosis previously diagnosed. After induction, the horse was shortly hoisted by all four feet, moved on a padded surgical table, and positioned in right lateral recumbency. In order to reduce the risk of bleeding during surgical manipulation of the carotid and maxillary arteries, a mean arterial pressure between 60 and 70 mmHg was targeted. After surgery, the horse was moved in a padded recovery box keeping the same lateral recumbency...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29464188/glycine-receptor-modulating-antibody-predicting-treatable-stiff-person-spectrum-disorders
#2
Shannon R Hinson, A Sebastian Lopez-Chiriboga, James H Bower, Joseph Y Matsumoto, Anhar Hassan, Eati Basal, Vanda A Lennon, Sean J Pittock, Andrew McKeon
Background: Glycine receptor alpha-1 subunit (GlyRα1)-immunoglobulin G (IgG) is diagnostic of stiff-person syndrome (SPS) spectrum but has been reported detectable in other neurologic diseases for which significance is less certain. Methods: To assess GlyRα1-IgGs as biomarkers of SPS spectrum among patients and controls, specimens were tested using cell-based assays (binding [4°C] and modulating [antigen endocytosing, 37°C]). Medical records of seropositive patients were reviewed...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29460826/defining-clinical-posturographic-and-intra-posturographic-discordances-what-do-these-two-concepts-mean
#3
REVIEW
Philippe Perrin, Art Mallinson, Christian Van Nechel, Laetitia Peultier-Celli, Hannes Petersen, Mans Magnusson, Herman Kingma, Raphaël Maire
The European Society for Clinical Evaluation of Balance Disorders - ESCEBD - Executive Committee meets yearly to identify and address clinical equilibrium problems that are not yet well understood. This particular discussion addressed "discordances" (defined as "lack of agreement") in clinical assessment. Sometimes there is disagreement between a clinical assessment and measured abnormality (ies); sometimes the results within the assessment do not agree. This is sometimes thought of as "malingering" or an attempt to exaggerate what is wrong, but this is not always the case...
February 20, 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29458924/effect-of-olfactory-stimulation-with-essential-oils-on-cardiovascular-reactivity-during-the-moving-beans-task-in-stroke-patients-with-anxiety
#4
Kazuaki Iokawa, Masahiro Kohzuki, Toshimasa Sone, Satoru Ebihara
OBJECTIVE: To investigate the effect of olfactory stimulation with essential oils on cardiovascular reactivity during the "moving beans" rehabilitation task in stroke patients with anxiety. METHODS: Twenty-eight stroke patients participated in this study. Blood pressure and heart rate were measured before and after finger movement tasks (e.g., moving beans and the Purdue pegboard test). Olfactory stimulation with lavender oil, grapefruit oil, and distilled water were conducted during finger tasks...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29425773/cocaine-and-amphetamine-regulated-transcript-peptide-cart-alleviates-mk-801-induced-schizophrenic-dementia-like-symptoms
#5
Chandrashekhar D Borkar, Ashish P Bharne, B Nagalakshmi, Amul J Sakharkar, Nishikant K Subhedar, Dadasaheb M Kokare
Exaggerated thoughts, diminished mood and impaired cognition are the hallmarks of the schizophrenia-like condition. These symptoms are attributed to the dysregulation of dopamine and glutamate signaling in the brain. Since cocaine- and amphetamine-regulated transcript peptide (CART) modulates actions of dopamine as well as glutamate, we tested the role of this peptide in MK-801 induced schizophrenic dementia-like condition. MK-801 treated rats were allowed to interact with conspecific juvenile and tested for short-term (30-min) and long-term (24-hr) social memory acquisition and recall...
February 6, 2018: Neuroscience
https://www.readbyqxmd.com/read/29388694/an-extension-of-the-perseverative-cognition-hypothesis-to-posttraumatic-stress-disorder-symptomatology-cardiovascular-recovery-in-relation-to-posttraumatic-stress-disorder-severity-and-cognitive-appraisals-of-stress
#6
Jeffrey L Kibler
Beyond the construct of cardiovascular reactivity, the measurement of cardiovascular recovery from stress represents an important index of exaggerated physiological arousal and disease risk. Cardiovascular recovery in posttraumatic stress disorder (PTSD) has not received adequate attention. The present study examined whether cardiovascular recovery following an oral speaking stressor was associated with the severity of PTSD symptoms, and whether cognitive stress appraisals of threat and challenge were significantly associated with PTSD severity and recovery...
February 1, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29382814/social-affective-context-reveals-altered-network-dynamics-in-schizophrenia-patients
#7
Talma Hendler, Gal Raz, Solnik Shimrit, Yael Jacob, Tamar Lin, Leor Roseman, Wahid Madah Wahid, Ilana Kremer, Marina Kupchik, Moshe Kotler, Maya Bleich-Cohen
Impairments in social cognition and interactions are core psychopathologies in schizophrenia, often manifesting as an inability to appropriately relate to the intentions and feelings of others. Neuroimaging has helped to demarcate the dynamics of two distinct functional connectivity circuits underlying the social-affective processes related to mentalization (known as Theory of Mind, ToM) and somatic-affiliation (known as Embodied Simulation, ES). While evidence points to abnormal activation patterns within these networks among those suffering from schizophrenia, it is yet unclear however, if these patients exhibit this abnormal functional connectivity in the context of social-affective experiences...
January 31, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29382712/corticosterone-production-during-repeated-social-defeat-causes-monocyte-mobilization-from-the-bone-marrow-glucocorticoid-resistance-and-neurovascular-adhesion-molecule-expression
#8
Anzela Niraula, Yufen Wang, Jonathan P Godbout, John F Sheridan
Repeated social defeat (RSD) stress promotes the release of bone marrow-derived monocytes into circulation that are recruited to the brain, where they augment neuroinflammation and cause prolonged anxiety-like behavior. Physiological stress activates the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal gland (HPA) axis, and both of these systems play a role in the physiological, immunological, and behavioral responses to stress. The purpose of this study was to delineate the role of HPA activation and corticosterone production in the immunological responses to stress in male C57/BL6 mice...
January 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29381817/oscillatory-activity-in-the-cortico-basal-ganglia-thalamic-neural-circuits-in-parkinson-s-disease
#9
Arun Singh
Dopamine is an important neurotransmitter that maintains the balance within the basal ganglia between the direct pathway, which promotes movement, and the indirect pathway, which inhibits movement. Degeneration of dopaminergic neurons in the substantia nigra increases the influence of the indirect pathway, resulting in motor dysfunction in Parkinson's disease (PD). The direct and indirect pathways are composed of cortical areas, basal ganglia, and thalamic nuclei, which are interconnected via independent parallel loop circuits and often referred to as cortico-basal ganglia-thalamic (CBT) neural circuits...
January 30, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29379734/botulinum-toxin-and-benign-prostatic-hyperplasia
#10
REVIEW
Lay Guat Ng
Benign prostatic hyperplasia (BPH) is a clinical condition where lower urinary tract symptoms are caused by both a physically obstructing prostate as well as tight smooth muscles around the bladder outlet. Treatment of this condition with botulinum toxin has been used since 2003, but this interest has somewhat died down after two large randomized controlled trials (RCTs) showing equivalence of results between their treatment and placebo arms. However, with review of animal studies and unexplained exaggerated effect of the placebo arms of the two RCTs, together with recent data of sustained benefits after 18 months of treatment, the place of botulinum toxin in the BPH field is probably still present...
January 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29343965/postural-tachycardia-syndrome-current-perspectives
#11
REVIEW
Rachel Wells, Andrew J Spurrier, Dominik Linz, Celine Gallagher, Rajiv Mahajan, Prashanthan Sanders, Amanda Page, Dennis H Lau
Postural tachycardia syndrome (POTS) is the combination of an exaggerated heart rate response to standing, in association with symptoms of lightheadedness or pre-syncope that improve when recumbent. The condition is often associated with fatigue and brain fog, resulting in significant disruptions at a critical time of diagnosis in adolescence and young adulthood. The heterogeneity of the underlying pathophysiology and the variable response to therapeutic interventions make management of this condition challenging for both patients and physicians alike...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29338111/the-exaggerated-blood-pressure-response-to-exercise-in-the-sub-acute-phase-after-stroke-is-not-affected-by-aerobic-exercise
#12
Magnus O Wijkman, Klas Sandberg, Marie Kleist, Lars Falk, Paul Enthoven
The prevalence of an exaggerated exercise blood pressure (BP) response is unknown in patients with subacute stroke, and it is not known whether an aerobic exercise program modulates this response. The authors randomized 53 patients (27 women) with subacute stroke to 12 weeks of twice-weekly aerobic exercise (n = 29) or to usual care without scheduled physical exercise (n = 24). At baseline, 66% of the patients exhibited an exaggerated exercise BP response (peak systolic BP ≥210 mm Hg in men and ≥190 mm Hg in women) during a symptom-limited ergometer exercise test...
January 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29297656/introduction-to-pseudobulbar-affect-setting-the-stage-for-recognition-and-familiarity-with-this-challenging-disorder
#13
Tammie Lee Demler
Pseudobulbar affect (PBA), despite its prevalence and distinctive symptoms, is widely underrecognized and undertreated. It is characterized by uncontrollable laughing or crying that can occur in an exaggerated manner or inappropriately to a given situation or stimuli. PBA is thought to center around preexisting neurological conditions, which include Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer disease, traumatic brain injury, and stroke. The PBA Registry Series trial was created to measure the prevalence of PBA among patients with these underlying neurological conditions...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29258545/dendrimer-mediated-delivery-of-n-acetyl-cysteine-to-microglia-in-a-mouse-model-of-rett-syndrome
#14
Elizabeth Nance, Siva P Kambhampati, Elizabeth S Smith, Zhi Zhang, Fan Zhang, Sarabdeep Singh, Michael V Johnston, Kannan Rangaramanujam, Mary E Blue, Sujatha Kannan
BACKGROUND: Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in the brain mediated by glial dysfunction have been implicated in the pathogenesis and worsening of symptoms of RTT. In this study, we investigated a new nanotherapeutic approach to target glia for attenuation of brain inflammation/injury both in vitro and in vivo using a Mecp2-null mouse model of Rett syndrome...
December 19, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29250014/gender-differences-in-posttraumatic-stress-symptoms-after-a-terrorist-attack-a-network-approach
#15
Marianne S Birkeland, Ines Blix, Øivind Solberg, Trond Heir
Background: Posttraumatic stress symptoms are more prevalent in women than in men. To improve our understanding of gender differences in PTSD, detailed knowledge about the underlying symptom networks and gender specific symptom profiles is needed. Objective: We aimed to describe the gender differences in levels of individual posttraumatic stress symptoms after a terrorist attack, as well as identify possible gender differences in associations between posttraumatic stress symptoms. Method: This study used survey data from ministerial employees directly (n = 190) and indirectly (n = 1,615) exposed to the 2011 Oslo bombing...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29227126/intentional-inattention-detecting-feigned-attention-deficit-hyperactivity-disorder-on-the-personality-assessment-inventory
#16
Shannon T Smith, Jennifer Cox, Elyse N Mowle, John F Edens
Given the increasing number of college students seeking Attention-Deficit/Hyperactivity Disorder (ADHD) diagnoses as well as the potential secondary gains associated with this disorder (e.g., access to stimulant medication, academic accommodations), the detection of malingered symptom presentations in this population is a major concern. The present study examined the ability of validity indicators on the widely used Personality Assessment Inventory (PAI; Morey, 1991) to distinguish between individuals experiencing genuine ADHD symptoms and individuals instructed to present with ADHD symptomatology for secondary gain...
December 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29201937/variance-in-mood-symptoms-across-menstrual-cycles-implications-for-premenstrual-dysphoric-disorder
#17
Tierney K Lorenz, Amanda N Gesselman, Virginia J Vitzthum
Premenstrual dysphoric disorder (PMDD) remains a controversial diagnosis: Some authors have argued that it pathologizes normal mood changes, and others have questioned the need for daily mood reports across multiple cycles. In the present study, we examined changes in mood among psychologically healthy young participants with regular menstrual cycles. We collected daily reports of negative mood (depression, nervousness, irritability, and fatigue) across two to six consecutive cycles from 27 participants aged 18-35 years, and we used variance decomposition analyses to examine how much of the variance in these daily reports was due to day, cycle, and individual...
2017: Women's Reproductive Health
https://www.readbyqxmd.com/read/29201928/abnormal-pain-response-after-a-compensable-shoulder-injury
#18
Helen Razmjou, Dragana Boljanovic, Amr Elmaraghy, Iona Macritchie, Carolyn Roknic, Danielle Medeiros, Robin R Richards
Background: The role of psychosocial factors has been established in patients with shoulder abnormalities. However, the prevalence of exaggerated pain behaviors and their association with the characteristics of injured workers have not been well studied. Purpose: To examine the prevalence of abnormal pain responses (APRs) in workers with active workers' compensation claims for a shoulder injury and to examine the differences between workers with APRs versus workers without APRs...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29201831/an-infantile-case-of-sandhoff-disease-presenting-with-swallowing-difficulty
#19
Jae-Gun Moon, Min-A Shin, Hannah Pyo, Seong-Uk Choi, Hyun-Kyung Kim
Infants with Sandhoff disease typically appear normal until 3-6 months of age. As the disease progresses, they present with symptoms such as loss of motor skills, exaggerated startle response to loud noise, seizures, visual loss, and paralysis. We encountered a rare case of a 22-month-old girl with Sandhoff disease characterized by progressive motor weakness and dysphagia, who initially showed signs of aspiration at 20 months of age. The major problems related to dysphagia were oromotor dysfunction and abnormal feeding posture...
October 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29171432/locomotor-analysis-identifies-early-compensatory-changes-during-disease-progression-and-subgroup-classification-in-a-mouse-model-of-amyotrophic-lateral-sclerosis
#20
Melissa M Haulcomb, Rena M Meadows, Whitney M Miller, Kathryn P McMillan, MeKenzie J Hilsmeyer, Xuefu Wang, Wesley T Beaulieu, Stephanie L Dickinson, Todd J Brown, Virginia M Sanders, Kathryn J Jones
Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in survival. Early identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease progression. Use of the mSOD1G93A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients, while investigating underlying disease-induced changes...
October 2017: Neural Regeneration Research
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