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Oxygen in myocardial infarction

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https://www.readbyqxmd.com/read/29229611/opposing-actions-of-fibroblast-and-cardiomyocyte-smad3-signaling-in-the-infarcted-myocardium
#1
Ping Kong, Arti V Shinde, Ya Su, Ilaria Russo, Bijun Chen, Amit Saxena, Simon J Conway, Jonathan M Graff, Nikolaos G Frangogiannis
Background -Transforming Growth Factor (TGF)-βs regulate a wide range of cellular responses by activating Smad-dependent and Smad-independent cascades. In the infarcted heart, Smad3 signaling is activated in both cardiomyocytes and interstitial cells. We hypothesized that cell-specific actions of Smad3 regulate repair and remodeling in the infarcted myocardium. Methods -In order to dissect cell-specific Smad3 actions in myocardial infarction, we generated mice with Smad3 loss in activated fibroblasts, or in cardiomyocytes...
December 11, 2017: Circulation
https://www.readbyqxmd.com/read/29226465/supplemental-oxygen-therapy-does-not-affect-the-systemic-inflammatory-response-to-acute-myocardial-infarction
#2
R Hofmann, P Tornvall, N Witt, J Alfredsson, L Svensson, L Jonasson, L Nilsson
BACKGROUND: Oxygen therapy has been used routinely in normoxemic patients with suspected acute myocardial infarction (AMI) despite limited evidence supporting a beneficial effect. AMI is associated with a systemic inflammation. Here, we hypothesized that the inflammatory response to AMI is potentiated by oxygen therapy. METHODS: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (DETO2X-AMI) multicentre trial randomized patients with suspected AMI to receive oxygen at 6 L min-1 for 6-12 h or ambient air...
December 11, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29222074/changes-of-oxygen-consumption-and-heart-rate-after-acute-myocardial-infarction-during-6-month-follow-up
#3
Yuri Choe, Jae-Young Han, In-Sung Choi, Hyeng-Kyu Park
BACKGROUND: Exercise intensity is a particularly important determinant of physiological responses to exercise training in patients with acute myocardial infarction. Heart rate (HR) is commonly used as a practical way of prescribing and monitoring exercise as specific intensities based on linear relationship between the percentage of maximum heart rate (%HRmax) and the percentage of maximum oxygen consumption (%VO2max) regardless of age, sex or exercise mode. OBJECTIVE: To examine the change in variability in the correlation between %HRmax and %VO2maxafter acute myocardial infarction...
December 5, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29221351/extracorporeal-membrane-oxygenation-system-as-a-bridge-to-reparative-surgery-in-ventricular-septal-defect-complicating-acute-inferoposterior-myocardial-infarction
#4
Jose Rozado, Isaac Pascual, Pablo Avanzas, Daniel Hernandez-Vaquero, Ruben Alvarez, Rocio Díaz, Beatriz Díaz, María Martín, Amelia Carro, Guillermo Muñiz, Jacobo Silva, Cesar Moris
Post-infarction ventricular septal defect (VSD) is a rare but potentially lethal complication of acute myocardial infarction. Medical management is usually futile, so definitive surgery remains the treatment of choice but the risk surgery is very high and the optimal timing for surgery is still under debate. A 55-year-old man with no previous medical history attended the emergency-room for 12 h evolution of oppressive chest pain and strong anginal pain 7 days ago. On physical examination, blood pressure was 96/70 mmHg, pansystolic murmur over left sternal border without pulmonary crackles...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29212895/functional-metabolomics-characterizes-a-key-role-for-n-acetyl-neuraminic-acid-in-coronary-artery-diseases
#5
Lei Zhang, Ting-Ting Wei, Yong Li, Jing Li, Yong Fan, Feng-Qing Huang, Yuan-Yuan Cai, Gaoxiang Ma, Jin-Feng Liu, Qian-Qian Chen, Shi-Lei Wang, Honglin Li, Raphael N Alolga, Baolin Liu, Dong-Sheng Zhao, Jian-Hua Shen, Xiang-Ming Wang, Wei Zhu, Ping Li, Lian-Wen Qi
Background -As new biomarkers of coronary artery diseases (CAD) emerge via metabolomics, the underlying functional mechanisms remain to be elucidated. Functional metabolomics aims to translate metabolomics-derived biomarkers to disease mechanisms. Methods -A cohort of 2324 patients who underwent coronary angiography from 4 independent centers was studied. A combination of ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) in the negative ion mode was employed for untargeted analysis of metabolites in plasma...
December 6, 2017: Circulation
https://www.readbyqxmd.com/read/29210291/use-of-cerebral-oxygen-saturation-and-hemoglobin-concentration-to-predict-acute-kidney-injury-after-cardiac-surgery
#6
Canan Balci, Engin Haftaci, Atike Tekeli Kunt
Objective Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with significant morbidity and mortality. Near infrared spectroscopy (NIRS) is a noninvasive technique for real-time measurement of cerebral tissue oxygenation. The purpose of the present study was to evaluate the correlation of AKI with hemoglobin and regional cerebral oxygen saturation (rScO2) measured intraoperatively and postoperatively in patients undergoing cardiac surgery. Methods We retrospectively analyzed the prospectively collected data of 45 adult patients with normal renal function who underwent isolated coronary artery bypass grafting (CABG) from January 2014 to May 2014...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29209026/qskl-protects-against-myocardial-apoptosis-on-heart-failure-via-pi3k-akt-p53-signaling-pathway
#7
Hong Chang, Chun Li, Qiyan Wang, Linghui Lu, Qian Zhang, Yi Zhang, Na Zhang, Yong Wang, Wei Wang
The ancient traditional Chinese medicine Qishenkeli (QSKL) is widely used in the treatment of heart failure (HF) in China. Previous studies have shown that QSKL has definite effects on HF. The purpose of this study is to identify the regulation of QSKL on apoptosis and clarify the underlying mechanism. An apoptosis model of H9C2 cells was induced by oxygen-glucose deprivation/recovery (OGD/R). An animal model of HF was induced by ligation of left anterior descending (LAD) coronary artery in rat. We found that QSKL reduced intracellular ROS generation, increased mitochondrial membrane potential and protected H9C2 cells against OGD/R-induced apoptosis...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208507/myrtenol-protects-against-myocardial-ischemia-reperfusion-injury-through-antioxidant-and-anti-apoptotic-dependent-mechanisms
#8
Raquel Moreira de Britto, Júlio Alves da Silva Neto, Thássio Ricardo Ribeiro Mesquita, Carla Maria Lins de Vasconcelos, Grace Kelly Melo de Almeida, Itamar Couto Guedes de Jesus, Péligris Henrique Dos Santos, Diego Santos de Souza, Rodrigo Miguel-Dos-Santos, Lucas Andrade de Sá, Fanildes Silva Moraes Dos Santos, Rose Nely Pereira-Filho, Ricardo Luiz Cavalcanti Albuquerque-Júnior, Lucindo José Quintans-Júnior, Silvia Guatimosim, Sandra Lauton-Santos
Myrtenol is a monoterpene with multiple pharmacological activities. However, although monoterpenes have been proposed to play beneficial roles in a variety of cardiac disorders, pharmacological actions of myrtenol in the heart are not yet reported. Hence, the aim of this study was to evaluate whether myrtenol promotes cardioprotection against myocardial ischemia-reperfusion (IR) injury, and the mechanisms involved in these effects. Male Wistar rats were orally treated for seven consecutive days with myrtenol (50 mg/kg) or N-acetyl cysteine (1...
December 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29207024/geraniin-protects-bone-marrow%C3%A2-derived-mesenchymal-stem-cells-against-hydrogen-peroxide%C3%A2-induced-cellular-oxidative-stress-in-vitro
#9
Dan Huang, Li Yin, Xinxin Liu, Bo Lv, Zulong Xie, Xuedong Wang, Bo Yu, Yao Zhang
Administration of bone marrow‑derived mesenchymal stem cells (MSCs) has emerged as a potential therapeutic approach for the treatment of myocardial infarction (MI). However, the increase in reactive oxygen species (ROS) in ischemic cardiac tissue compromises the survival of transplanted MSCs, thus resulting in limited therapeutic efficiency. Therefore, strategies that attenuate oxidative stress‑induced damage and enhance MSC viability are required. Geraniin has been reported to possess potent antioxidative activity and exert protective effects on numerous cell types under certain conditions...
November 21, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29198085/-the-diagnostic-and-therapeutic-challenge-of-type-2-myocardial-infraction
#10
Lotem Harel, Eyal Avivi, Alex Blatt, Micha Rapoport
Type 2 Myocardial Infarction (Type 2 MI) is considered to result from an imbalance between demand and supply of oxygen in the myocardium, other than coronary plaque instability. It is highly prevalent in internal departments and is strongly associated with mortality. To date, there is no consensus regarding the diagnostic criteria for type 2 MI and no available guidelines regarding the optimal management of this condition. We present a case study of a 64 years old male who was hospitalized with lower gastrointestinal bleeding...
November 2017: Harefuah
https://www.readbyqxmd.com/read/29196046/prehospital-antibiotics-in-the-ambulance-for-sepsis-a-multicentre-open-label-randomised-trial
#11
Nadia Alam, Erick Oskam, Patricia M Stassen, Pieternel van Exter, Peter M van de Ven, Harm R Haak, Frits Holleman, Arthur van Zanten, Hien van Leeuwen-Nguyen, Victor Bon, Bart A M Duineveld, Rishi S Nannan Panday, Mark H H Kramer, Prabath W B Nanayakkara
BACKGROUND: Emergency medical services (EMS) personnel have already made substantial contributions to improving care for patients with time-dependent illnesses, such as trauma and myocardial infarction. Patients with sepsis could also benefit from timely prehospital care. METHODS: After training EMS personnel in recognising sepsis, we did a randomised controlled open-label trial in ten large regional ambulance services serving 34 secondary and tertiary care hospitals in the Netherlands...
November 28, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29194090/the-association-between-uric-acid-levels-and-different-clinical-manifestations-of-coronary-artery-disease
#12
Trine R Larsen, Oke Gerke, Axel C P Diederichsen, Jess Lambrechtsen, Flemming H Steffensen, Niels P Sand, Lotte Saaby, Steen Antonsen, Hans Mickley
AIMS: Uric acid (UA) has been associated with the presence and severity of coronary artery disease. To further assess the role of UA role in coronary artery disease, we investigated UA levels in both healthy asymptomatic middle-aged individuals and in different subgroups of hospitalized patients with suspected or definite myocardial infarction (MI). PATIENTS AND METHODS: The severity of coronary artery calcification (CAC) was examined in asymptomatic individuals (n=1039) using a noncontrast computed tomography scan...
November 29, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29184499/aliskiren-improves-ischemia-and-oxygen-glucose-deprivation-induced-cardiac-injury-through-activation-of-autophagy-and-amp-activated-protein-kinase
#13
Ming-Hsien Chiang, Chan-Jung Liang, Chen-Wei Liu, Bo-Jhih Pan, Wen-Ping Chen, Yi-Fan Yang, I-Ta Lee, Jaw-Shiun Tsai, Chiang-Wen Lee, Yuh-Lien Chen
Aliskiren is a direct renin inhibitor that has been effective in anti-hypertension. We investigated whether aliskiren could improve the ischemia-induced cardiac injury and whether the autophagy was involved in this effect. A myocardial infarction (MI) model was created by the ligation of the left anterior coronary artery in C57J/BL6 mice. They were treated for 1, 3, 7, and 14 days with vehicle or aliskiren (25 mg/kg/day via subcutaneous injection). In vivo, the MI mice exhibited worse cardiac function by echocardiographic assessment and showed larger myocardial scarring by light microscopy, whereas aliskiren treatment reversed these effects, which were also associated with the changes in caspase-3 and Bcl-2 expression as well as in the number of apoptotic cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29184434/manifestation-of-non-st-elevation-myocardial-infarction-due-to-hyperthyroidism-in-an-anomalous-right-coronary-artery
#14
Vicken Zeitjian, Carmel Moazez, Mehrdad Saririan, David L August, Ranjini Roy
Introduction: Anomalous origin of the right coronary artery (RCA) from the left coronary cusp of the aorta is a moderately rare but potentially life-threatening incident. Myocardial infarction (MI) and sudden cardiac death have been described with this anomaly, especially in those who engage in excessive exercise. However, this case study shows this incidence in association with hyperthyroidism. Case description: A previously healthy 51-year-old female with history of hypothyroidism presented with acute onset chest pain for 1 day...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29183830/improving-cannulation-time-for-extracorporeal-life-support-in-refractory-cardiac-arrest-of-presumed-cardiac-cause-comparison-of-two-percutaneous-cannulation-techniques-in-the-catheterization-laboratory-in-a-center-without-on-site-cardiovascular-surgery
#15
Sebastian Voicu, Patrick Henry, Isabelle Malissin, Dillinger Jean-Guillaume, Anastasios Koumoulidis, Nikos Magkoutis, Demetris Yannopoulos, Damien Logeart, Stéphane Manzo-Silberman, Nicolas Péron, Nicolas Deye, Bruno Megarbane, Georgios Sideris
BACKGROUND: Cardiac arrest (CA) without return of spontaneous circulation can be treated with veno-arterial extracorporeal membrane oxygenation (vaECMO) implemented surgically or percutaneously. We performed a study assessing time for vaECMO percutaneous cannulation in the catheterization laboratory. METHODS: Single-centre retrospective study in a University hospital without on-site cardiovascular surgery, including patients aged >18 receiving vaECMO for out- or in-hospital refractory CA of presumed cardiac cause between 2010 and 2016, cannulated by interventional cardiologists...
November 26, 2017: Resuscitation
https://www.readbyqxmd.com/read/29179205/overexpression-of-timp3-protects-against-cardiac-ischemia-reperfusion-injury-by-inhibiting-myocardial-apoptosis-through-ros-mapks-pathway
#16
Hui Liu, Xibo Jing, Aiqiao Dong, Baobao Bai, Haiyan Wang
BACKGROUND/AIMS: Myocardial ischemia/reperfusion (I/R) injury remains a great challenge in clinical therapy. Tissue inhibitor of metalloproteinases 3 (TIMP3) plays a crucial role in heart physiological and pathophysiological processes. However, the effects of TIMP3 on I/R injury remain unknown. METHODS: C57BL/6 mice were infected with TIMP3 adenovirus by local delivery in myocardium followed by I/R operation or doxorubicin treatment. Neonatal rat cardiomyocytes were pretreated with TIMP3 adenovirus prior to anoxia/reoxygenation (A/R) treatment in vitro...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29177025/acute-exposure-to-cigarette-smoking-followed-by-myocardial-infarction-aggravates-renal-damage-in-an-in-vivo-mouse-model
#17
Firas Kobeissy, Abdullah Shaito, Abdullah Kaplan, Lama Baki, Hassan Hayek, Carole Dagher-Hamalian, Ali Nehme, Rana Ghali, Emna Abidi, Ahmad Husari, Asad Zeidan, Fouad A Zouein, Kazem Zibara
Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial infarction (MI) using 4 groups: control (C), smoking (S), MI, and S+MI. Histological analysis of S+MI group showed alterations in kidney structure including swelling of the proximal convoluted tubules (PCTs), thinning of the epithelial lining, focal loss of the brush border of PCTs, and patchy glomerular retraction...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29169886/a-potential-diagnostic-pitfall-in-acute-chest-pain-massive-pulmonary-embolism-mimicking-acute-st-elevation-myocardial-infarction
#18
Ya-Wen Lu, Yi-Lin Tsai, Chun-Chin Chang, Po-Hsun Huang
BACKGROUND: Pulmonary embolism (PE) represents a clinical challenge for clinicians because of nonspecific presentations, including dyspnea, chest pain, and tachycardia. The immediate 12-lead electrocardiogram (ECG) is commonly used to facilitate differential diagnosis of acute chest pain. Although relative rare, massive pulmonary embolism could induce ST segment elevation and mimic acute myocardial infarction. CASE PRESENTATION: We present a challenging scenario that ECG showed ST segment elevation, nevertheless, urgent coronary angiogram revealed non-obstructive coronary artery disease...
November 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29146117/implications-of-disturbances-in-circadian-rhythms-for-cardiovascular-health-a-new-frontier-in-free-radical-biology
#19
REVIEW
Neelam Khaper, Craig D C Bailey, Nilesh R Ghugre, Cristine Reitz, Zikra Awosanmi, Ryan Waines, Tami A Martino
Cell autonomous circadian "clock" mechanisms are present in virtually every organ, and generate daily rhythms that are important for normal physiology. This is especially relevant to the cardiovascular system, for example the circadian mechanism orchestrates rhythms in heart rate, blood pressure, cardiac contractility, metabolism, gene and protein abundance over the 24-hour day and night cycles. Conversely, disturbing circadian rhythms (e.g. via shift work, sleep disorders) increases cardiovascular disease risk, and exacerbates cardiac remodelling and worsens outcome...
November 13, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29140548/a-phase-ib-open-label-single-arm-study-to-assess-the-safety-pharmacokinetics-and-impact-on-humoral-sensitization-of-sanguinate-infusion-in-patients-with-end-stage-renal-disease
#20
Bassam G Abu Jawdeh, E Steve Woodle, Abbie D Leino, Paul Brailey, Simon Tremblay, Tonya Dorst, Mouhamad H Abdallah, Amit Govil, Daniel Byczkowski, Hemant Misra, Abraham Abuchowski, Rita R Alloway
The endeavor to study desensitization in kidney transplantation hasn't been matched by an effort to investigate strategies to prevent sensitization. In this study (NCT02437422), we investigated the safety, impact on sensitization and pharmacokinetics of SANGUINATE (SG), a hemoglobin-based oxygen carrier, as a potential alternative to packed red blood cells (PRBC) in transplant candidates with end-stage renal disease (ESRD). Ten ESRD subjects meeting inclusion/exclusion (I/E) criteria were planned to receive 3 weekly infusions of SG (320mg/Kg)...
November 15, 2017: Clinical Transplantation
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