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Oxygen in myocardial infarction

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https://www.readbyqxmd.com/read/28820076/a-novel-danshensu-tetramethylpyrazine-conjugate-dt-018-provides-cardioprotection-by-preserving-mitochondrial-function-through-the-mef2d-pgc-1%C3%AE-pathway
#1
Xiaojing Zhang, Jingxiong Luo, Yali Huang, Huixing Deng, Huihui Hu, Pei Yu, Yewei Sun, Luchen Shan, Yuqiang Wang
In this work, we explored the protective effect of DT-018, a danshensu and tetramethylpyrazine conjugate, on mitochondrial injury induced by tert-butylhydroperoxide (t-BHP) and its possible mechanisms of action. DT-018 effectively quenched intracellular and mitochondrial reactive oxygen species (ROS), preserved the mitochondrial function, restored the intracellular level of ATP and augmented mitochondrial membrane potential (ΔΨm) while suppressed mitochondrial swelling in isolated myocardial mitochondria...
August 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28819000/hypoxia-induced-myocardial-regeneration
#2
Wataru Kimura, Yuji Nakada, Hesham A Sadek
The underlying cause of systolic heart failure is the inability of the adult mammalian heart to regenerate damaged myocardium. In contrast, some vertebrate species and immature mammals are capable of full cardiac regeneration following multiple types of injury through cardiomyocyte proliferation. Little is known about what distinguishes proliferative cardiomyocytes from terminally differentiated, non-proliferative cardiomyocytes. Recently, several reports have suggested that oxygen metabolism and oxidative stress play a pivotal role in regulating the proliferative capacity of mammalian cardiomyocytes...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28817623/metformin-attenuates-myocardial-ischemia-reperfusion-injury-via-up-regulation-of-antioxidant-enzymes
#3
Xiaoling Wang, Lei Yang, Licheng Kang, Jing Li, Liang Yang, Jincai Zhang, Jie Liu, Mengmeng Zhu, Qiong Zhang, Yanna Shen, Zhi Qi
The objective was to examine the protective effect of metformin (Met) on myocardial ischemia-reperfusion (IR) injury and whether the mechanism was related to the AMPK/ antioxidant enzymes signaling pathway. Rat Langendorff test and H2O2-treated rat cardiomyocytes (H9c2) were used in this study. Met treatment significantly improved left ventricular (LV) function, reduced infarct size and CK-MB release in comparison with IR group. Decreased TUNEL staining positive cells were also observed in IR+Met group ex vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28814985/activation-of-endocannabinoid-receptor-2-as-a-mechanism-of-propofol-pretreatment-induced-cardioprotection-against-ischemia-reperfusion-injury-in-rats
#4
Hai-Jing Sun, Yan Lu, Hao-Wei Wang, Hao Zhang, Shuang-Ran Wang, Wen-Yun Xu, Hai-Long Fu, Xue-Ya Yao, Feng Yang, Hong-Bin Yuan
Propofol pretreatment before reperfusion, or propofol conditioning, has been shown to be cardioprotective, while its mechanism is unclear. The current study investigated the roles of endocannabinoid signaling in propofol cardioprotection in an in vivo model of myocardial ischemia/reperfusion (I/R) injury and in in vitro primary cardiomyocyte hypoxia/reoxygenation (H/R) injury. The results showed that propofol conditioning increased both serum and cell culture media concentrations of endocannabinoids including anandamide (AEA) and 2-arachidonoylglycerol (2-AG) detected by LC-MS/MS...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28804535/hongjingtian-injection-attenuates-myocardial-oxidative-damage-via-promoting-autophagy-and-inhibiting-apoptosis
#5
Shujing Zhang, Ling Zhang, Han Zhang, Guanwei Fan, Jiuwen Qiu, Zongbao Fang, Haibo Wu, Yi Wang, Xiaoping Zhao
Natural products with antioxidative activities are widely applied to prevent and treat various oxidative stress related diseases, including ischemic heart disease. However, the cellular and molecular mechanisms of those therapies are still needed to be illustrated. In this study, we characterized the cardioprotective effects of Hongjingtian Injection (HJT), an extensively used botanical drug for treating coronary heart disease. The H/R-induced profound elevation of oxidative stress was suppressed by HJT. HJT also attenuates oxidative injury by promoting cell viability, intracellular ATP contents, and mitochondrial oxygen consumption...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28801525/exercise-of-obese-mice-induces-cardioprotection-and-oxygen-sparing-in-hearts-exposed-to-high-fat-load
#6
Neoma T Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum
Exercise training is a potent, therapeutic approach in obesity and diabetes that exerts protective effects against development of diabetic cardiomyopathy and ischemic-injury. Acute increases in circulating fatty acids (FAs) during an ischemic insult can challenge the heart, as high FA-load is considered to have adverse cardiac effects. In the present study, we tested the hypothesis that exercise-induced cardiac effects in diet-induced obese mice are abrogated by an acute high FA-load. Diet-induced obese mice were fed a high-fat diet (HFD) for 20 weeks...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28798772/study-of-erythrocyte-indices-erythrocyte-morphometric-indicators-and-oxygen-binding-properties-of-hemoglobin-hematoporphyrin-patients-with-cardiovascular-diseases
#7
Victor V Revin, Antonina A Ushakova, Natalia V Gromova, Larisa A Balykova, Elvira S Revina, Vera V Stolyarova, Tatiana A Stolbova, Ilya N Solomadin, Alexander Yu Tychkov, Nadezhda V Revina, Oksana G Imarova
The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in blood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after treatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting disorders are observed. Standard therapy does not result in the restoration of the structure and properties of erythrocytes. The authors believe that it is necessary for future therapeutic treatment to include preparations other than cardiovascular agents to enhance the capacity of hemoglobin to transport oxygen to the tissues...
2017: Advances in Hematology
https://www.readbyqxmd.com/read/28780351/down-regulation-of-lncrna-kcnq1ot1-protects-against-myocardial-ischemia-reperfusion-injury-following-acute-myocardial-infarction
#8
Xin Li, Yingnan Dai, Shujun Yan, Yanli Shi, Baihe Han, Jingxiu Li, Li Cha, Jianjun Mu
This study aimed to investigate the protective effects of long non-coding RNA KCNQ1OT1 against myocardial ischemia/reperfusion (I/R) injury following acute myocardial infarction, as well as its regulatory mechanism. We used the cardiac muscle H9c2 cells under condition of oxygen glucose deprivation followed by reperfusion (OGD/R) to induce myocardial I/R injury. Then H9C2 cells were transfected with si-NC, si-KCNQ1OT1, pc-NC, pc-KCNQ1OT1, si-AdipoR1 and si-AdipoR2, respectively. The myocardial cell viability and apoptosis were respectively detected...
August 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28777704/noninvasive-identification-of-renal-hypoxia-in-experimental-myocardial-infarctions-of-different-sizes-by-using-bold-mr-imaging-in-a-mouse-model
#9
Di Chang, Yuan-Cheng Wang, Ting-Ting Xu, Xin-Gui Peng, Yu Cai, Lin Wang, Ying-Ying Bai, Shenghong Ju
Purpose To test the feasibility of using blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging to measure alterations in renal oxygenation in a mouse model with experimental myocardial infarctions (MIs) of different sizes. Materials and Methods The study was approved by the local animal ethics committee. One hundred eighty-nine male C57BL/6 J mice were randomly subjected to MI surgery (with different locations of left anterior descending coronary artery occlusion) or sham surgery, defined as the exposure of the heart but no ligation...
August 4, 2017: Radiology
https://www.readbyqxmd.com/read/28776067/determinants-of-survival-and-favorable-neurologic-outcomes-in-ischemic-heart-disease-treated-by-veno-arterial-extracorporeal-membrane-oxygenation
#10
Keisuke Yonezu, Kenichi Sakakura, Yusuke Watanabe, Yousuke Taniguchi, Kei Yamamoto, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
Overall mortality and neurologic outcome of patients treated by veno-arterial extracorporeal membrane oxygenation (V-A ECMO) was still not satisfactory. The aim of this study was to clarify the determinants of survival and favorable neurologic outcomes in patients with ischemic heart disease (IHD) treated by V-A ECMO. We identified IHD patients who received V-A ECMO, and divided those patients into the survived and the in-hospital death group. Multivariate logistic regression analysis was performed to identify the determinants of survival and favorable neurologic outcomes...
August 3, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28771799/modulation-of-nfkb1-p50-by-ros-leads-to-impaired-atp-production-during-mi-compared-to-cardiac-hypertrophy
#11
Arkadeep Mitra, Ritwik Datta, Santanu Rana, Sagartirtha Sarkar
Pathological hypertrophy and myocardial infarction (MI) are two etiologically different cardiac disorders having differential molecular mechanisms of disease manifestation. However, no study has been conducted so far to analyze and compare the differential status of energy metabolism in these two disease forms. It was shown recently by our group that production of ATP is significantly impaired during MI along with inhibition of pyruvate dehydrogenase E1-β (PDHE1 B) by pyruvate dehydrogenase kinase 4 (PDK4)...
August 3, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28770021/effects-of-antioxidant-supplements-on-the-survival-and-differentiation-of-stem-cells
#12
REVIEW
Sara Shaban, Mostafa Wanees Ahmed El-Husseny, Abdelrahman Ibrahim Abushouk, Amr Muhammad Abdo Salem, Mediana Mamdouh, Mohamed M Abdel-Daim
Although physiological levels of reactive oxygen species (ROS) are required to maintain the self-renewal capacity of stem cells, elevated ROS levels can induce chromosomal aberrations, mitochondrial DNA damage, and defective stem cell differentiation. Over the past decade, several studies have shown that antioxidants can not only mitigate oxidative stress and improve stem cell survival but also affect the potency and differentiation of these cells. Further beneficial effects of antioxidants include increasing genomic stability, improving the adhesion of stem cells to culture media, and enabling researchers to manipulate stem cell proliferation by using different doses of antioxidants...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28764841/non-st-elevation-acute-coronary-syndromes-a-comprehensive-review
#13
Tamunoinemi Bob-Manuel, Ikechuckwu Ifedili, Guy Reed, Uzoma N Ibebuogu, Rami N Khouzam
Non-ST elevation-acute coronary syndrome (NSTE-ACS) includes NSTE myocardial infarction and unstable angina. This patient population forms approximately two-thirds of all hospital admissions for ACS in the United States each year and is associated with an in-hospital mortality of 5%. NSTE-ACS is primarily due to an acute change in the supply and demand balance of coronary perfusion and myocardial oxygen consumption, because of the significant coronary artery obstruction presenting as plaque rupture or erosion...
September 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/28759485/targeting-hypoxia-signaling-for-perioperative-organ-injury
#14
Xiaoyi Yuan, Jae W Lee, Jessica L Bowser, Viola Neudecker, Srikanth Sridhar, Holger K Eltzschig
Perioperative organ injury has a significant impact on surgical outcomes and presents a leading cause of death in the United States. Recent research has pointed out an important role of hypoxia signaling in the protection from organ injury, including for example myocardial infarction, acute respiratory distress syndrome, acute kidney, or gut injury. Hypoxia induces the stabilization of hypoxia-inducible factors (HIFs), thereby leading to the induction of HIF target genes, which facilitates adaptive responses to low oxygen...
July 27, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28756653/mir-23a-regulates-cardiomyocyte-apoptosis-by-targeting-manganese-superoxide-dismutase
#15
Bo Long, Tian-Yi Gan, Rong-Cheng Zhang, Yu-Hui Zhang
Cardiomyocyte apoptosis is initiated by various cellular insults and accumulated cardiomyocyte apoptosis leads to the pathogenesis of heart failure. Excessive reactive oxygen species (ROS) provoke apoptotic cascades. Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme that converts cellular ROS into harmless products. In this study, we demonstrate that MnSOD is down-regulated upon hydrogen peroxide treatment or ischemia/reperfusion (I/R) injury. Enhanced expression of MnSOD attenuates cardiomyocyte apoptosis and myocardial infarction induced by I/R injury...
July 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28746145/treatment-and-outcomes-of-type-2-myocardial-infarction-and-myocardial-injury-compared-with-type-1-myocardial-infarction
#16
Nathaniel R Smilowitz, Pritha Subramanyam, Eugenia Gianos, Harmony R Reynolds, Binita Shah, Steven P Sedlis
BACKGROUND: Type 2 myocardial infarction (MI) is defined by a rise and fall of cardiac biomarkers and evidence of ischemia without unstable coronary artery disease (CAD) because of a mismatch in myocardial oxygen supply and demand. Myocardial injury is similar but does not fulfill the clinical criteria for MI. There is uncertainty in terms of the clinical characteristics, management, and outcomes of type 2 MI and myocardial injury in comparison with type 1 MI. PATIENTS AND METHODS: Patients admitted to a Veterans Affairs tertiary care hospital with a rise and fall in cardiac troponin were identified...
July 25, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28746082/heartware-ventricular-assist-device-as-a-bridge-to-transplant-in-a-small-boy-with-complicated-kawasaki-disease
#17
Christopher E Mascio, Dhananjay P Malankar, Jonathan J Rome
We report a case of HeartWare ventricular assist device (HVAD) implant as a Bridge-to-Transplant in the smallest and the youngest known patient, a 32-month-old boy (body surface area of 0.66 m2) with known Kawasaki disease and giant coronary artery aneurysms. The disease course was complicated by coronary thromboembolism resulting in acute myocardial infarction, ventricular fibrillation, and cardiac arrest. After short-term support with extracorporeal membrane oxygenation for 7 days and long-term support with an HVAD for 5 months, he underwent heart transplantation and is doing well 2 months after the transplant...
July 25, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28745664/-predictors-of-cerebral-complications-during-carotid-endarterectomy
#18
O V Kamenskaya, I Yu Loginova, V V Lomivorotov
AIM: To evaluate the prognostic value of parameters of cerebral oxygenation in estimation of the risk of ischemic stroke (IS) in perioperative and early postoperative phase of carotid endarterectomy (CEE). MATERIAL AND METHODS: Four hundred and sixty-six patients with hemodynamically significant atherosclerotic lesion of arteries of the brachiocephalic system, who underwent CEE with bilateral monitoring of cerebral oxygenation (rSO2), were enrolled. The end-point of the study was cerebral complications in perioperative and early postoperative phase...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28735838/cardiovascular-effects-of-air-pollution
#19
REVIEW
Thomas Bourdrel, Marie-Abèle Bind, Yannick Béjot, Olivier Morel, Jean-François Argacha
Air pollution is composed of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide and ozone. PM is classified according to size into coarse particles (PM10), fine particles (PM2.5) and ultrafine particles. We aim to provide an original review of the scientific evidence from epidemiological and experimental studies examining the cardiovascular effects of outdoor air pollution. Pooled epidemiological studies reported that a 10μg/m(3) increase in long-term exposure to PM2.5 was associated with an 11% increase in cardiovascular mortality...
July 20, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28721144/clinical-implications-of-plasma-nogo-a-levels-in-patients-with-coronary-heart-disease
#20
Yu Ding, Bei-Bei Gao, Liang Zhou, Xian-Hua Ye, Hong Li, Lei Lai, Jin-Yu Huang
INTRODUCTION: Nogo-A is an important neurite growth-regulatory protein in the adult and developing nervous system. Recently, increasing evidence has shown that Nogo-A plays important roles in cardiac development and may act as a potential indicator for heart failure. In addition, increased oxidative stress has been found in individuals with cardiovascular diseases. However, not much is known regarding the expression levels of Nogo-A and reactive oxygen species (ROS) in patients with coronary heart disease (CHD)...
June 2017: Archives of Medical Science: AMS
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