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Oxygen in myocardial infarction

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https://www.readbyqxmd.com/read/29453330/interphysician-agreement-on-subclassification-of-myocardial-infarction
#1
Anton Gard, Bertil Lindahl, Gorav Batra, Nermin Hadziosmanovic, Marcus Hjort, Karolina Elisabeth Szummer, Tomasz Baron
OBJECTIVE: The universal definition of myocardial infarction (MI) differentiates MI due to oxygen supply/demand mismatch (type 2) from MI due to plaque rupture (type 1) as well as from myocardial injuries of non-ischaemic or multifactorial nature. The purpose of this study was to investigate how often physicians agree in this classification and what factors lead to agreement or disagreement. METHODS: A total of 1328 patients diagnosed with MI at eight different Swedish hospitals 2011 were included...
February 16, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29452370/blood-cardioplegia-for-cardiac-surgery-in-acute-myocardial-infarction-rat-experiments-with-two-widely-used-solutions
#2
Andreas Boening, Lena Assling-Simon, Martina Heep, Kerstin Boengler, Bernd Niemann, Julia Schipke, Christian Mühlfeld, Philippe Grieshaber
OBJECTIVES: Blood cardioplegia (BCP) can be used in different ways to protect the heart from ischaemia-reperfusion injury during cardiac surgery. Because there could be differences between warm and cold intermittent cardioplegia with or without warm reperfusion, we investigated the influence of 2 blood cardioplegia solutions on cardiac function, metabolism and infarct size in stable and infarcted rat hearts. METHODS: The hearts of 32 male Wistar rats were excised and inserted into a blood-perfused isolated heart apparatus...
February 14, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#3
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
February 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29445778/nadph-oxidase-4-driven-cardiac-macrophage-polarization-protects-against-myocardial-infarction-induced-remodeling
#4
Heloise Mongue-Din, Ashish S Patel, Yee H Looi, David J Grieve, Narayana Anilkumar, Alexander Sirker, Xuebin Dong, Alison C Brewer, Min Zhang, Alberto Smith, Ajay M Shah
The reactive oxygen species-generating enzyme NADPH oxidase 4 (Nox4) is up-regulated in the heart after myocardial infarction (MI). Mice with cardiomyocyte-targeted Nox4 overexpression (TG) displayed increased macrophages in the heart at baseline, with skewing toward an M2 phenotype compared with wild-type controls (WT). After MI, TG mice had a higher proportion of M2 macrophages along with higher survival, decreased cardiac remodeling, and better contractile function than wild-type mice. The post-MI increase in cardiac matrix metalloproteinase-2 activity was substantially blunted in TG mice...
December 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/29439446/the-t2238c-human-atrial-natriuretic-peptide-molecular-variant-and-the-risk-of-cardiovascular-diseases
#5
REVIEW
Speranza Rubattu, Sebastiano Sciarretta, Simona Marchitti, Franca Bianchi, Maurizio Forte, Massimo Volpe
Atrial natriuretic peptide (ANP) is a cardiac hormone which plays important functions to maintain cardio-renal homeostasis. The peptide structure is highly conserved among species. However, a few gene variants are known to fall within the human ANP gene. The variant rs5065 (T2238C) exerts the most substantial effects. The T to C transition at the 2238 position of the gene (13-23% allele frequency in the general population) leads to the production of a 30-, instead of 28-, amino-acid-long α-carboxy-terminal peptide...
February 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29436868/effect-of-oxygen-therapy-on-chest-pain-in-patients-with-st-elevation-myocardial-infarction-results-from-the-randomized-soccer-trial
#6
Ardavan Khoshnood, Mahin Akbarzadeh, Marcus Carlsson, David Sparv, Pallonji Bhiladvala, Arash Mokhtari, David Erlinge, Ulf Ekelund
OBJECTIVE: Oxygen (O 2 ) have been a cornerstone in the treatment of acute myocardial infarction. Studies have been inconclusive regarding the cardiovascular and analgesic effects of oxygen in these patients. In the SOCCER trial, we compared the effects of oxygen treatment versus room air in patients with ST-elevation myocardial infarction (STEMI). There was no difference in myocardial salvage index or infarct size assessed with cardiac magnetic resonance imaging. In the present subanalysis, we wanted to evaluate the effect of O 2 on chest pain in patients with STEMI...
February 13, 2018: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29432894/buckberg-s-blood-cardioplegia-for-protection-of-adult-and-senile-myocardium-in-a-rat-in-vitro-model-of-acute-myocardial-infarction
#7
Andreas Boening, Lena Assling-Simon, Martina Heep, Kerstin Boengler, Bernd Niemann, Philippe Grieshaber
BACKGROUND: In patients undergoing surgical myocardial revascularization for acute myocardial infarction, excellent myocardial protection can be achieved by blood cardioplegia. We investigated the influence of age on cardiac function, metabolism, and infarct size using Buckberg's blood cardioplegia (BCP). METHODS: The hearts of male Wistar rats ("adult", age 3 months, n = 8; "senile", age 24 months, n = 8) were excised and mounted on a blood-perfused isolated heart apparatus...
February 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29431119/hypermetabolic-macrophages-in-rheumatoid-arthritis-and-coronary-artery-disease-due-to-glycogen-synthase-kinase-3b-inactivation
#8
Markus Zeisbrich, Rolando E Yanes, Hui Zhang, Ryu Watanabe, Yinyin Li, Lukas Brosig, Jison Hong, Barbara B Wallis, John C Giacomini, Themistocles L Assimes, Jörg J Goronzy, Cornelia M Weyand
OBJECTIVES: Accelerated atherosclerotic disease typically complicates rheumatoid arthritis (RA), leading to premature cardiovascular death. Inflammatory macrophages are key effector cells in both rheumatoid synovitis and the plaques of coronary artery disease (CAD). Whether both diseases share macrophage-dependent pathogenic mechanisms is unknown. METHODS: Patients with RA or CAD (at least one myocardial infarction) and healthy age-matched controls were recruited into the study...
February 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29425550/efficacy-of-intramyocardial-injection-of-algisyl-lvr-for-the-treatment-of-ischemic-heart-failure-in-swine
#9
Jenny S Choy, Shuang Leng, Gabriel Acevedo-Bolton, Semion Shaul, Lijuan Fu, Xiaomei Guo, Liang Zhong, Julius M Guccione, Ghassan S Kassab
BACKGROUND: Progressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac function. We sought to evaluate the efficacy of a biopolymer (Algisyl-LVR) to prevent left ventricular (LV) remodeling in a swine model of IHF. METHODS: IHF was induced in 11 swine by occluding the marginal obtuse branches of the left circumflex artery...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29424914/microrna-298-regulates-apoptosis-of-cardiomyocytes-after-myocardial-infarction
#10
Q Zhang, N Yu, B-T Yu
OBJECTIVE: To investigate the role and mechanism of micro ribonucleic acid (miR)-298 in myocardial apoptosis after myocardial infarction. MATERIALS AND METHODS: In vivo experiments, the rat model of myocardial infarction was established, and miR-298 was up-regulated via lentivirus with miR-298 overexpression. Cardiac function of rats was detected via echocardiography, Bcl-2 associated X protein (BAX) expressions in infarction border zone were detected via Real-time Quantitative PCR (qT-PCR) and Western blot, and TUNEL assay was used to detect the myocardial apoptosis...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29421020/effects-of-hyperoxia-on-myocardial-injury-following-cardioversion-a-randomized-clinical-trial
#11
Kasper Glerup Lauridsen, Anders Sjørslev Schmidt, Kasper Adelborg, Leif Bach, Nete Hornung, Simon Munkesø Jepsen, Charles D Deakin, Hans Rickers, Bo Løfgren
Oxygen has long been assumed beneficial for all ill and injured patients. However, hyperoxia may be harmful and aggravate myocardial injury such as that caused by myocardial infarction. We aimed to investigate if hyperoxia increases myocardial injury following direct current cardioversion compared with room air. METHODS: Patients undergoing elective biphasic cardioversion for atrial fibrillation or atrial flutter were randomized to receive room air or oxygen (10-15 L/min) during the procedure...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29420842/acute-myocardial-infarction-complicated-with-ventricular-septal-rupture-and-intracranial-hemorrhage
#12
Munevver Sari, Gokhan Kahveci, Alev Kilicgedik, Mehmet Ayturk, Selcuk Pala
Ventricular septal rupture (VSR) is a rare but fatal complication of acute myocardial infarction (AMI) with an associated mortality that ranges from 41% to 80%. The treatment consists of supplemental oxygenation, afterload reduction, intraaortic balloon pump, and surgical repair. In selected patients, extracorporeal membrane oxygenation (ECMO) and/or percutaneous closure of the defect can be considered if anatomically appropriate. Echocardiography evaluates the morphology and location of the defect, anatomical concerns for percutaneous closure, and accompanying pathologies...
February 8, 2018: Echocardiography
https://www.readbyqxmd.com/read/29416745/itraq-analysis-of-a-mouse-acute-myocardial-infarction-model-reveals-that-vitamin-d-binding-protein-promotes-cardiomyocyte-apoptosis-after-hypoxia
#13
Yun Wu, Fen Liu, Xiang Ma, Dilare Adi, Ming-Tao Gai, Xiang Jin, Yi-Ning Yang, Ying Huang, Xiang Xie, Xiao-Mei Li, Zhen-Yan Fu, Bang-Dang Chen, Yi-Tong Ma
The proteome profile changes after acute myocardial infarction (AMI) and the roles played by important protein species remain poorly understood. Here, we constructed a mouse AMI model by ligating the left coronary artery of male C57B/6J mice to investigate the molecular changes after AMI on the protein level. Total proteins of the left ventricle were extracted and quantitatively analyzed by isobaric tags using relative and absolute quantitation (iTRAQ) technologies. The transcript and protein levels of important genes were further validated using quantitative polymerase chain reaction and western blot...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415653/xanthine-oxidase-inhibitors-for-prevention-of-cardiovascular-events-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#14
Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d'Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein, Guilherme Gomes Dias Campos
BACKGROUND: Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive oxygen species derived from purine metabolism. Oxidative stress is an important factor related to endothelial dysfunction and ischemia-reperfusion injury, and may be implicated in the pathogenesis of heart failure, hypertension, and ischemic heart disease. However, there is contradictory evidence regarding the possible cardiovascular (CV) protective effect exerted by XOI...
February 7, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29408518/a-chlorogenic-acid-phospholipid-complex-ameliorates-post-myocardial-infarction-inflammatory-response-mediated-by-mitochondrial-reactive-oxygen-species-in-samp8-mice
#15
Yi Li, Xuecong Ren, Chonkit Lio, Wenxia Sun, Ke Lai, Yuan Liu, Zhifeng Zhang, Jie Liang, Hua Zhou, Liang Liu, Jing Ren, Pei Luo
Mitochondrial reactive oxygen species (mtROS) directly stimulate the inflammatory cytokines cascades and participate in age-related changes of cardiovascular diseases. Application of small molecule targeting the mtROS is significant towards development of better therapy to combat inflammatory response after myocardial infarction (MI) in the aging heart. Chlorogenic acid (CGA) is a well-known natural compound while the clinical potential is largely stifled by its poor oral absorption. In the present study, we tested the protective effect of a novel chlorogenic acid-phospholipid complex (CGA-PC) against acute post-MI inflammation in aged senescence accelerated mouse model...
February 2, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29397689/dual-roles-of-graphene-oxide-to-attenuate-inflammation-and-elicit-timely-polarization-of-macrophage-phenotypes-for-cardiac-repair
#16
Jin Han, Yong Sook Kim, Min-Young Lim, Han Young Kim, Saerom Kong, Mikyung Kang, Yeon Woong Choo, Ju Hee Jun, Seungmi Ryu, Hye-Yun Jeong, Jooyeon Park, Gun-Jae Jeong, Jong-Chan Lee, Gwang Hyeon Eom, Youngkeun Ahn, Byung-Soo Kim
Development of localized inflammatory environments by M1 macrophages in the cardiac infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the regulation of inflammation by M1 macrophages and their timely polarization toward regenerative M2 macrophages suggest an immunotherapy. Particularly, controlling cellular generation of reactive oxygen species (ROS), which cause M1 differentiation, and developing M2 macrophage phenotypes in macrophages propose a therapeutic approach. Previously, stem or dendritic cells were used in MI for their anti-inflammatory and cardioprotective potentials and showed inflammation modulation and M2 macrophage progression for cardiac repair...
February 7, 2018: ACS Nano
https://www.readbyqxmd.com/read/29394331/vascular-smooth-muscle-contraction-in-hypertension
#17
Rhian M Touyz, Rheure Alves-Lopes, Francisco J Rios, Livia L Camargo, Aikaterini Anagnostopoulou, Anders Arner, Augusto C Montezano
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease. Pathophysiological mechanisms contributing to the development of hypertension include increased vascular resistance, determined in large part by reduced vascular diameter due to increased vascular contraction and arterial remodelling. These processes are regulated by complex interacting systems such as the renin angiotensin aldosterone system (RAAS), sympathetic nervous system, immune activation and oxidative stress, which influence vascular smooth muscle function...
January 31, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29385043/interplay-between-ros-and-antioxidants-during-ischemia-reperfusion-injuries-in-cardiac-and-skeletal-muscle
#18
REVIEW
Tingyang Zhou, Evan R Prather, Davis E Garrison, Li Zuo
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR injury in striated muscles involve the production of reactive oxygen species (ROS). Excessive ROS accumulation results in cellular oxidative stress, mitochondrial dysfunction, and initiation of cell death by activation of the mitochondrial permeability transition pore. Elevated ROS levels can also decrease myofibrillar Ca2+ sensitivity, thereby compromising muscle contractile function...
January 31, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29383727/increasing-cardiac-pyruvate-dehydrogenase-flux-during-chronic-hypoxia-improves-acute-hypoxic-tolerance
#19
Michal K Handzlik, Dumitru Constantin-Teodosiu, Paul L Greenhaff, Mark A Cole
The pattern of metabolic reprogramming in chronic hypoxia shares similarities with that following myocardial infarction or hypertrophy, however the response of the chronically hypoxic heart to subsequent acute injury, and the role of metabolism is not well understood. Here, we determined the myocardial tolerance of the chronically hypoxic heart to subsequent acute injury, and hypothesised that activation of a key regulator of myocardial metabolism, the pyruvate dehydrogenase complex (PDC), could improve hypoxic tolerance...
January 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29379385/protection-by-ethanolic-extract-from-ulva-lactuca-l-against-acute-myocardial-infarction-antioxidant-and-antiapoptotic-activities
#20
Wahyu Widyaningsih, Suwidjiyo Pramono, Zulaela, Sugiyanto, Sitarina Widyarini
Background: Reactive oxygen species (ROS) play a major role in myocardial damage during acute myocardial infarction (AMI). This study aimed to determine the antioxidant and antiapoptotic activities of an ethanolic extract from Ulva lactuca L. (EEUL) against AMI. Methods: Thirty-six male Wistar rats were divided into six groups: one control group and five treatment groups. Treatment group II was given 85 mg/kg body weight (BW) of isoproterenol (ISO). Group III, IV and V were given ISO and EEUL at 250, 500 and 750 mg/kg BW, respectively...
December 2017: Malaysian Journal of Medical Sciences: MJMS
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