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https://www.readbyqxmd.com/read/27913284/cardiac-proteasome-functional-insufficiency-plays-a-pathogenic-role-in-diabetic-cardiomyopathy
#1
Jie Li, Wenxia Ma, Guihua Yue, Yaoliang Tang, Il-Man Kim, Neal L Weintraub, Xuejun Wang, Huabo Su
BACKGROUND: Diabetic cardiomyopathy is a major risk factor in diabetic patients but its pathogenesis remains poorly understood. The ubiquitin-proteasome system (UPS) facilitates protein quality control by degrading unnecessary and damaged proteins in eukaryotic cells, and dysfunction of UPS is implicated in various cardiac diseases. However, the overall functional status of the UPS and its pathophysiological role in diabetic cardiomyopathy have not been determined. METHODS AND RESULTS: Type I diabetes was induced in wild-type and transgenic mice expressing a UPS functional reporter (GFPdgn) by injections of streptozotocin (STZ)...
November 29, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27579044/stem-cell-released-microvesicles-and-exosomes-as-novel-biomarkers-and-treatments-of-diseases
#2
Yanfang Chen, Yaoliang Tang, Weiwen Long, Chunxiang Zhang
No abstract text is available yet for this article.
2016: Stem Cells International
https://www.readbyqxmd.com/read/26868211/profound-actions-of-an-agonist-of-growth-hormone-releasing-hormone-on-angiogenic-therapy-by-mesenchymal-stem-cells
#3
QunChao Ma, Xiangyang Xia, Quanwei Tao, Kai Lu, Jian Shen, Qiyuan Xu, Xinyang Hu, Yaoliang Tang, Norman L Block, Keith A Webster, Andrew V Schally, Jian'an Wang, Hong Yu
OBJECTIVE: The efficiency of cell therapy is limited by poor cell survival and engraftment. Here, we studied the effect of the growth hormone-releasing hormone agonist, JI-34, on mesenchymal stem cell (MSC) survival and angiogenic therapy in a mouse model of critical limb ischemia. APPROACH AND RESULTS: Mouse bone marrow-derived MSCs were incubated with or without 10(-8) mol/L JI-34 for 24 hours. MSCs were then exposed to hypoxia and serum deprivation to detect the effect of preconditioning on cell apoptosis, migration, and tube formation...
April 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/26445043/long-non-coding-rnas-as-master-regulators-in-cardiovascular-diseases
#4
REVIEW
Krystal Archer, Zuzana Broskova, Ahmed S Bayoumi, Jian-peng Teoh, Alec Davila, Yaoliang Tang, Huabo Su, Il-man Kim
Cardiovascular disease is the leading cause of death in the United States, accounting for nearly one in every seven deaths. Over the last decade, various targeted therapeutics have been introduced, but there has been no corresponding improvement in patient survival. Since the mortality rate of cardiovascular disease has not been significantly decreased, efforts have been made to understand the link between heart disease and novel therapeutic targets such as non-coding RNAs. Among multiple non-coding RNAs, long non-coding RNA (lncRNA) has emerged as a novel therapeutic in cardiovascular medicine...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26152686/identification-of-gene-signatures-regulated-by-carvedilol-in-mouse-heart
#5
Jian-Peng Teoh, Kyoung-Mi Park, Zuzana Broskova, Felix R Jimenez, Ahmed S Bayoumi, Krystal Archer, Huabo Su, John Johnson, Neal L Weintraub, Yaoliang Tang, Il-Man Kim
Chronic treatment with the β-blocker carvedilol has been shown to reduce established maladaptive left ventricle (LV) hypertrophy and to improve LV function in experimental heart failure. However, the detailed mechanisms by which carvedilol improves LV failure are incompletely understood. We previously showed that carvedilol is a β-arrestin-biased β1-adrenergic receptor ligand, which activates cellular pathways in the heart independent of G protein-mediated second messenger signaling. More recently, we have demonstrated by microRNA (miR) microarray analysis that carvedilol upregulates a subset of mature and pre-mature miRs, but not their primary miR transcripts in mouse hearts...
September 2015: Physiological Genomics
https://www.readbyqxmd.com/read/26000464/exosomes-microvesicles-from-induced-pluripotent-stem-cells-deliver-cardioprotective-mirnas-and-prevent-cardiomyocyte-apoptosis-in-the-ischemic-myocardium
#6
Yingjie Wang, Lan Zhang, Yongjun Li, Lijuan Chen, Xiaolong Wang, Wei Guo, Xue Zhang, Gangjian Qin, Sheng-hu He, Arthur Zimmerman, Yutao Liu, Il-man Kim, Neal L Weintraub, Yaoliang Tang
BACKGROUND/OBJECTIVES: Induced pluripotent stem cells (iPS) exhibit enhanced survival and proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited by their tumorigenic potential. We hypothesized that iPS cells can transmit cytoprotective signals to cardiomyocytes via exosomes/microvesicles. METHODS: Exosomes/microvesicles secreted from mouse cardiac fibroblast (CF)-derived iPS cells (iPS-exo) were purified from conditioned medium and confirmed by electron micrograph, size distribution and zeta potential by particle tracking analyzer and protein expression of the exosome markers CD63 and Tsg101...
August 1, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25824147/microrna-150-protects-the-mouse-heart-from-ischaemic-injury-by-regulating-cell-death
#7
Yaoping Tang, Yongchao Wang, Kyoung-Mi Park, Qiuping Hu, Jian-Peng Teoh, Zuzana Broskova, Punithavathi Ranganathan, Calpurnia Jayakumar, Jie Li, Huabo Su, Yaoliang Tang, Ganesan Ramesh, Il-Man Kim
AIMS: Cardiac injury is accompanied by dynamic changes in the expression of microRNAs (miRs). For example, miR-150 is down-regulated in patients with acute myocardial infarction, atrial fibrillation, dilated and ischaemic cardiomyopathy as well as in various mouse heart failure (HF) models. Circulating miR-150 has been recently proposed as a better biomarker of HF than traditional clinical markers such as brain natriuretic peptide. We recently showed using the β-arrestin-biased β-blocker, carvedilol that β-arrestin1-biased β1-adrenergic receptor cardioprotective signalling stimulates the processing of miR-150 in the heart...
June 1, 2015: Cardiovascular Research
https://www.readbyqxmd.com/read/25655221/a-novel-high-throughput-approach-to-screen-for-cardiac-arrhythmic-events-following-stem-cell-treatment
#8
William Tung, Neal L Weintraub, Adam E Berman, Yaoliang Tang
Although stem cell therapy is promising for repairing damaged cardiac tissue and improving heart function, there are safety concerns, especially regarding the risk of arrhythmias, which can be life threatening. To address this issue, we propose to develop a novel screening system to evaluate arrhythmic risk associated with stem cell therapy using a high-throughput multielectrode array system that can measure conduction velocity and action potential duration in cardiomyocytes co-cultured with different types of stem cells, such as mesenchymal stem cells, skeletal myoblasts, and resident cardiac stem cells...
April 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/25459138/enhancing-stem-cell-survival-in-an-ischemic-heart-by-crispr-dcas9-based-gene-regulation
#9
Alexander Pan, Neal L Weintraub, Yaoliang Tang
Ischemic heart disease has remained the number one killer around the world for over the past 20 years. While stem cell therapy has become a promising new frontier to repair the damaged heart, limited stem cell survivability post-transplantation has precluded widespread use of this therapy. Strategies to genetically modify stem cells to activate pro-survival and anti-apoptotic and anti-inflammatory pathways, such as Akt and heme oxygenase-1, have been shown to improve the lifespan of transplanted stem cells within the ischemic myocardium, but constitutive overexpression of these pathways at high levels has been shown to have side effects...
December 2014: Medical Hypotheses
https://www.readbyqxmd.com/read/24947528/transplanted-perivascular-adipose-tissue-accelerates-injury-induced-neointimal-hyperplasia-role-of-monocyte-chemoattractant-protein-1
#10
David Manka, Tapan K Chatterjee, Lynn L Stoll, Joshua E Basford, Eddy S Konaniah, Ramprasad Srinivasan, Vladimir Y Bogdanov, Yaoliang Tang, Andra L Blomkalns, David Y Hui, Neal L Weintraub
OBJECTIVE: Perivascular adipose tissue (PVAT) expands during obesity, is highly inflamed, and correlates with coronary plaque burden and increased cardiovascular risk. We tested the hypothesis that PVAT contributes to the vascular response to wire injury and investigated the underlying mechanisms. APPROACH AND RESULTS: We transplanted thoracic aortic PVAT from donor mice fed a high-fat diet to the carotid arteries of recipient high-fat diet-fed low-density lipoprotein receptor knockout mice...
August 2014: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/24944198/specific-inhibition-of-hdac4-in-cardiac-progenitor-cells-enhances-myocardial-repairs
#11
Ling X Zhang, Megan DeNicola, Xin Qin, Jianfeng Du, Julio Ma, Yu Tina Zhao, Shougang Zhuang, Paul Y Liu, Lei Wei, Gangjian Qin, Yaoliang Tang, Ting C Zhao
We have recently shown that in vivo inhibition of histone deacetylase (HDAC) stimulates endogenous myocardial regeneration in infarcted hearts (Zhang L et al. J Pharmacol Exp Ther 341: 285-293, 2012). Furthermore, our observation demonstrates that HDAC inhibition promotes cardiogenesis, which is associated with HDAC4 reduction. However, it remains unknown as to whether specific inhibition of HDAC4 modulates cardiac stem cells (CSCs) to facilitate myocardial repair and to preserve cardiac performance. c-kit(+) CSCs were isolated from adult mouse hearts and were transfected with HDAC4 siRNA to knockdown HDAC4 of c-kit(+) CSCs...
August 15, 2014: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/24925977/proinflammatory-phenotype-of-perivascular-adipocytes
#12
REVIEW
Abdullah Omar, Tapan K Chatterjee, Yaoliang Tang, David Y Hui, Neal L Weintraub
Perivascular adipose tissue (PVAT) directly abuts the lamina adventitia of conduit arteries and actively communicates with the vessel wall to regulate vascular function and inflammation. Mounting evidence suggests that the biological activities of PVAT are governed by perivascular adipocytes, a unique class of adipocyte with distinct molecular and phenotypic characteristics. Perivascular adipocytes surrounding human coronary arteries (pericoronary perivascular adipocytes) exhibit a reduced state of adipogenic differentiation and a heightened proinflammatory state, secreting ≤50-fold higher levels of the proinflammatory cytokine monocyte chemoattractant peptide-1 compared with adipocytes from other regional depots...
August 2014: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/24912616/assessing-in-vitro-stem-cell-function-and-tracking-engraftment-of-stem-cells-in-ischaemic-hearts-by-using-novel-irfp-gene-labelling
#13
Yingjie Wang, Mi Zhou, Xiaolong Wang, Gangjian Qin, Neal L Weintraub, Yaoliang Tang
Near-infrared fluorescence (NIRF) imaging by using infrared fluorescent protein (iRFP) gene labelling is a novel technology with potential value for in vivo applications. In this study, we expressed iRFP in mouse cardiac progenitor cells (CPC) by lentiviral vector and demonstrated that the iRFP-labelled CPC (CPC(iRFP)) can be detected by flow cytometry and fluorescent microscopy. We observed a linear correlation in vitro between cell numbers and infrared signal intensity by using the multiSpectral imaging system...
September 2014: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/24705900/mir-92a-inhibits-vascular-smooth-muscle-cell-apoptosis-role-of-the-mkk4-jnk-pathway
#14
Lan Zhang, Mi Zhou, Yingjie Wang, Weibin Huang, Gangjian Qin, Neal L Weintraub, Yaoliang Tang
Vascular smooth muscle cell (VSMC) apoptosis plays an important role in vascular remodeling and atherosclerotic plaque instability. Oxidative stress in diseased vessels promotes VSMC apoptosis in part by activating the c-Jun N-terminal kinase (JNK) pathway, which has been identified as a molecular target of miR-92a in macrophages. Here, we examined the expression and biological activity of miR-92a in VSMC. Quiescent VSMC exhibited a low basal expression of miR-92a, which was positively regulated by serum stimulation and negatively regulated by H2O2...
June 2014: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/24650666/mir-92a-regulates-viability-and-angiogenesis-of-endothelial-cells-under-oxidative-stress
#15
Lan Zhang, Mi Zhou, Gangjian Qin, Neal L Weintraub, Yaoliang Tang
Oxidative stress contributes to endothelial cell (EC) dysfunction, which is prevalent in ageing and atherosclerosis. MicroRNAs (miRs) are small, non-coding RNAs that post-transcriptionally regulate gene expression and play a key role in fine-tuning EC functional responses, including apoptosis and angiogenesis. MiR-92a is highly expressed in young endothelial cells in comparison with senescent endothelial cells, which exhibit increased oxidative stress and apoptosis. However, the impact of miR-92a treatment on EC viability and angiogenesis under oxidative stress is unknown...
April 18, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24394703/inhibition-of-stearoyl-coa-desaturase-selectively-eliminates-tumorigenic-nanog-positive-cells-improving-the-safety-of-ips-cell-transplantation-to-myocardium
#16
Lan Zhang, Yaohua Pan, Gangjian Qin, Lijuan Chen, Tapan K Chatterjee, Neal L Weintraub, Yaoliang Tang
Induced pluripotent stem cells (iPS) can differentiate into cardiomyocytes (CM) and represent a promising form of cellular therapy for heart regeneration. However, residual undifferentiated iPS derivates (iPSD), which are not fully eliminated by cell differentiation or purification protocols, may form tumors after transplantation, thus compromising therapeutic application. Inhibition of stearoyl-coA desaturase (SCD) has recently been reported to eliminate undifferentiated human embryonic stem cells, which share many features with iPSD...
2014: Cell Cycle
https://www.readbyqxmd.com/read/23807789/identification-of-stem-cells-after-transplantation
#17
Yingjie Wang, Lan Zhang, Yaohua Pan, Lijuan Chen, Neal Weintraub, Yaoliang Tang
The ability to identify the donor stem cells following transplantation into injured hearts is critical. This is particularly important in evaluating stem cell survival and lineage differentiation into mature cardiovascular cells. Several approaches have been employed for tracking the donor stem cells, including fluorescent dyes and fluorescent protein gene transfer. Here, we will induce a protocol using lentivirus-mediated green fluorescent protein (GFP) to monitor the fate of donor stem cells following transplantation...
2013: Methods in Molecular Biology
https://www.readbyqxmd.com/read/23807787/two-step-protocol-for-isolation-and-culture-of-cardiospheres
#18
Lijuan Chen, Yaohua Pan, Lan Zhang, Yingjie Wang, Neal Weintraub, Yaoliang Tang
Cardiac progenitor cells (CPC) are a unique pool of progenitor cells residing in the heart that play an important role in cardiac homeostasis and physiological cardiovascular cell turnover during acute myocardial infarction (MI). Transplanting CPC into the heart has shown promise in two recent clinical trials of cardiac repair (SCIPIO & CADUCEUS). CSCs were originally isolated directly from enzymatically digested hearts followed by cell sorting using stem cell markers. However, long exposure to enzymatic digestion can affect the integrity of stem cell markers on the cell surface and also compromise stem cell function...
2013: Methods in Molecular Biology
https://www.readbyqxmd.com/read/23737535/human-coronary-artery-perivascular-adipocytes-overexpress-genes-responsible-for-regulating-vascular-morphology-inflammation-and-hemostasis
#19
Tapan K Chatterjee, Bruce J Aronow, Wilson S Tong, David Manka, Yaoliang Tang, Vladimir Y Bogdanov, Dusten Unruh, Andra L Blomkalns, Mark G Piegore, Daniel S Weintraub, Steven M Rudich, David G Kuhel, David Y Hui, Neal L Weintraub
Inflammatory cross talk between perivascular adipose tissue and the blood vessel wall has been proposed to contribute to the pathogenesis of atherosclerosis. We previously reported that human perivascular (PV) adipocytes exhibit a proinflammatory phenotype and less adipogenic differentiation than do subcutaneous (SQ) adipocytes. To gain a global view of the genomic basis of biologic differences between PV and SQ adipocytes, we performed genome-wide expression analyses to identify differentially expressed genes between adipocytes derived from human SQ vs...
August 15, 2013: Physiological Genomics
https://www.readbyqxmd.com/read/23639284/mir-17-92-cluster-is-a-novel-regulatory-gene-of-cardiac-ischemic-reperfusion-injury
#20
Mi Zhou, Junfeng Cai, Yaoliang Tang, Qiang Zhao
The miR-17-92 cluster is an important microRNA cluster in the animals. It was mainly investigated as an oncogene in tumors but never studied in cardiovascular disease. On one aspect, miR-17-92 cluster is documented to play anti-apoptotic roles in tumor cells, including hypoxia-induced apoptosis. The families of miR-17, miR-19, and miR-92 promote resistance to apoptosis by directly inhibiting pro-apoptotic protein, and by the two major cell survival signaling pathways-PI3K/AKT, and MAPK/ERK. On the other aspect, the component members of miR-17-92 cluster are high expressed in the hearts of canine and mice, suggesting that there are effect targets of the cluster in the myocardium...
July 2013: Medical Hypotheses
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