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circulating tumors cells and colorectal liver metastases

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https://www.readbyqxmd.com/read/27648161/can-the-prognosis-of-colorectal-cancer-be-improved-by-surgery
#1
REVIEW
Yasumasa Takii, Satoshi Maruyama, Hitoshi Nogami
Surgical resection is the only curative treatment modality for colorectal cancer limited locally. Evidence for the kind of resection procedure that is effective for improving prognosis is insufficient. Prognosis improvement is expected with the no-touch isolation technique (NTIT), making it the most important resection procedure. We are conducting a multicenter randomized controlled trial (RCT) to confirm the efficacy of NTIT in patients with colorectal cancer. The present review serves as a preface to our trial, as it focuses on basic and clinical studies that support the efficacy of NTIT...
August 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27527865/the-vegf-rise-in-blood-of-bevacizumab-patients-is-not-based-on-tumor-escape-but-a-host-blockade-of-vegf-clearance
#2
Lejla Alidzanovic, Patrick Starlinger, Dominic Schauer, Thomas Maier, Alexandra Feldman, Elisabeth Buchberger, Judith Stift, Ulrike Koeck, Lorand Pop, Birgit Gruenberger, Thomas Gruenberger, Christine Brostjan
Vascular endothelial growth factor (VEGF) has become a major target in cancer treatment as it promotes tumor angiogenesis. Therapy with anti-VEGF antibody bevacizumab reportedly induces high levels of circulating VEGF which may potentially contribute to resistance. Based on animal or computational models, mechanisms of VEGF induction by bevacizumab have been proposed but not verified in the clinical setting. Hence, we evaluated sixty patients with colorectal cancer metastases for changes in plasma VEGF during neoadjuvant/conversion and adjuvant chemotherapy with or without bevacizumab...
August 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27340863/molecular-characteristics-of-circulating-tumor-cells-resemble-the-liver-metastasis-more-closely-than-the-primary-tumor-in-metastatic-colorectal-cancer
#3
Wendy Onstenk, Anieta M Sieuwerts, Bianca Mostert, Zarina Lalmahomed, Joan B Bolt-de Vries, Anne van Galen, Marcel Smid, Jaco Kraan, Mai Van, Vanja de Weerd, Raquel Ramírez-Moreno, Katharina Biermann, Cornelis Verhoef, Dirk J Grünhagen, Jan N M IJzermans, Jan W Gratama, John W M Martens, John A Foekens, Stefan Sleijfer
BACKGROUND: CTCs are a promising alternative for metastatic tissue biopsies for use in precision medicine approaches. We investigated to what extent the molecular characteristics of circulating tumor cells (CTCs) resemble the liver metastasis and/or the primary tumor from patients with metastatic colorectal cancer (mCRC). RESULTS: The CTC profiles were concordant with the liver metastasis in 17/23 patients (74%) and with the primary tumor in 13 patients (57%). The CTCs better resembled the liver metastasis in 13 patients (57%), and the primary tumor in five patients (22%)...
June 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27132185/mouse-and-human-liver-contain-immunoglobulin-a-secreting-cells-originating-from-peyer-s-patches-and-directed-against-intestinal-antigens
#4
Ludovic Moro-Sibilot, Pascal Blanc, Morgan Taillardet, Emilie Bardel, Coline Couillault, Gilles Boschetti, Alexandra Traverse-Glehen, Thierry Defrance, Dominique Kaiserlian, Bertrand Dubois
BACKGROUND & AIMS: The liver receives blood from the gastrointestinal tract through the portal vein, and thereby is exposed continuously to dietary antigens and commensal bacteria. Alcoholic liver disease (ALD) is associated with intestinal dysbiosis, increased intestinal permeability, release of microbes into the portal circulation, and increased serum levels and liver deposits of IgA. We characterized B-cell production of IgA in livers of mice at homeostasis, after oral immunization, in a mouse model of ALD and in human liver samples...
August 2016: Gastroenterology
https://www.readbyqxmd.com/read/26951177/letter-to-the-editor-a-meta-analysis-of-preoperative-circulating-and-disseminated-tumor-cells-are-negative-predictors-of-survival-in-patients-undergoing-hepatic-resection-of-colorectal-liver-metastases
#5
LETTER
Bin Ma, Longyi Wang, Peng Gao, Yongxi Song, Zhenning Wang
No abstract text is available yet for this article.
August 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/26714949/central-but-not-peripheral-circulating-tumor-cells-are-prognostic-in-patients-undergoing-resection-of-colorectal-cancer-liver-metastases
#6
Ashton A Connor, Kate McNamara, Eisar Al-Sukhni, Jacob Diskin, David Chan, Colleen Ash, Lori E Lowes, Alison L Allan, George Zogopoulos, Carol-Anne Moulton, Steven Gallinger
BACKGROUND: Colorectal cancer liver metastases (CRLMs) are potentially curable with resection, but most patients recur and succumb to their disease. Clinical covariates do not account for all outcomes. Circulating tumor cells (CTCs) are prognostic in the primary and metastatic settings of breast, prostate and colorectal cancer (CRC), and evolving evidence supports their role in CRLMs. Our objective was to determine whether CTCs in peripheral (PV) and hepatic venous (HV) compartments are associated with disease-free survival (DFS) and overall survival (OS) post-CRLM resection...
July 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25964582/profile-of-serum-factors-and-disseminated-tumor-cells-before-and-after-radiofrequency-ablation-compared-to-resection-of-colorectal-liver-metastases-a-pilot-study
#7
Sebastian Hinz, Jürgen Tepel, Christian Röder, Holger Kalthoff, Thomas Becker
BACKGROUND/AIM: The degree of systemic response after hepatic radiofrequency ablation (RFA) has not been well-compared to liver resection so far. This pilot study was designed to examine whether RFA, compared to liver resection, significantly varies concerning dissemination of circulating tumor cells and induction of different pro-inflammatory markers and liver-specific growth factors. PATIENTS AND METHODS: Patients with colorectal liver metastases were treated with RFA, a combination of RFA and resection or liver resection only...
May 2015: Anticancer Research
https://www.readbyqxmd.com/read/25956578/insertion-of-a-stent-in-obstructive-colon-cancer-can-induce-a-metastatic-process-in-an-experimental-murine-model
#8
Brice Malgras, Laura Brullé, Réa Lo Dico, Fatima El Marjou, Sylvie Robine, Amu Therwath, Marc Pocard
BACKGROUND: Colonic self-expanding metallic stents (SEMS) are used in obstructive colorectal cancer patients as a bridge to surgery. However, its oncologic safety remains uncertain. Therefore, we attempted to clarify this further with an experimental study and constructed a mouse model of colonic cancer. METHODS: CT26 cells were injected in the rectal wall, and to mimic SEMS, a cardiac stent was inserted under endoscopy in occlusive (75 % lumen occlusion) tumors...
December 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25807199/circulating-tumor-cell-isolation-during-resection-of-colorectal-cancer-lung-and-liver-metastases-a-prospective-trial-with-different-detection-techniques
#9
Jussuf T Kaifi, Miriam Kunkel, Avisnata Das, Ramdane A Harouaka, David T Dicker, Guangfu Li, Junjia Zhu, Gary A Clawson, Zhaohai Yang, Michael F Reed, Niraj J Gusani, Eric T Kimchi, Kevin F Staveley-O'Carroll, Si-Yang Zheng, Wafik S El-Deiry
BACKGROUND: Colorectal cancer (CRC) metastasectomy improves survival, however most patient develop recurrences. Circulating tumor cells (CTCs) are an independent prognostic marker in stage IV CRC. We hypothesized that CTCs can be enriched during metastasectomy applying different isolation techniques. METHODS: 25 CRC patients undergoing liver (16 (64%)) or lung (9 (36%)) metastasectomy were prospectively enrolled (clinicaltrial.gov identifier: NCT01722903). Central venous (liver) or radial artery (lung) tumor outflow blood (7...
2015: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/25806877/clinico-pathological-correlation-of-serial-measurement-of-circulating-tumor-cells-in-24-metastatic-colorectal-cancer-patients-receiving-chemotherapy-reveals-interpatient-heterogeneity-correlated-with-cea-levels-but-independent-of-kras-and-braf-mutation
#10
Avisnata Das, Miriam Kunkel, Jamal Joudeh, David T Dicker, Angelique Scicchitano, Joshua E Allen, Nabeel Sarwani, Zhaohai Yang, Jussuf Kaifi, Junjia Zhu, Jason Liao, Wafik S El-Deiry
BACKGROUND: The Veridex CellSearch is an FDA-approved technology for enumerating circulating tumor cells in blood samples of metastatic colorectal cancer mCRC) patients and has prognostic value. It is important to understand how counts of circulating tumor cells (CTCs), which are advocated to be tools for "liquid biopsy" of tumors, correlate with clinical and pathologic variables of significance in these patients. In this study, we have attempted to make such correlations along with evaluating how CTC counts change during the course of chemotherapy...
2015: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/25801354/detection-of-circulating-tumor-cells-at-surgery-and-at-follow-up-assessment-to-predict-survival-after-two-stage-liver-resection-of-colorectal-liver-metastases
#11
Kristoffer Watten Brudvik, Lars Thomas Seeberg, Harald Hugenschmidt, Anne Renolen, Cecilie Bendigtsen Schirmer, Cathrine Brunborg, Bjørn Atle Bjørnbeth, Elin Borgen, Bjørn Naume, Anne Waage, Gro Wiedswang
BACKGROUND: The presence of circulating tumor cells (CTCs) is negatively associated with survival after resection of colorectal liver metastases (CLM). The current study aimed to determine the prognostic value of CTCs and disseminated tumor cells (DTCs) at the time of surgery and the prognostic value of CTCs at follow-up assessment, for patients scheduled to undergo two-stage hepatectomy with portal vein embolization (PVE) for CLM. METHODS: Samples were collected at surgery (blood and bone marrow) and at follow-up assessment (blood) for the period 2008 through 2011...
November 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25115394/circulating-mir-182-is-a-biomarker-of-colorectal-adenocarcinoma-progression
#12
Lisa Perilli, Caterina Vicentini, Marco Agostini, Silvia Pizzini, Marco Pizzi, Edoardo D'Angelo, Stefania Bortoluzzi, Susanna Mandruzzato, Enzo Mammano, Massimo Rugge, Donato Nitti, Aldo Scarpa, Matteo Fassan, Paola Zanovello
MiR-182 expression was evaluated by qRT-PCR and in situ hybridization in 20 tubular adenomas, 50 colorectal carcinoma (CRC), and 40 CRC liver metastases. Control samples obtained from patients with irritable bowel syndrome, or tumor-matched normal colon mucosa were analyzed (n=50). MiR-182 expression increased progressively and significantly along with the colorectal carcinogenesis cascade, and in CRC liver metastases. The inverse relation between miR-182 and the expression of its target gene ENTPD5 was investigated by immunohistochemical analysis...
August 30, 2014: Oncotarget
https://www.readbyqxmd.com/read/25086965/high-lung-shunt-fraction-in-colorectal-liver-tumors-is-associated-with-distant-metastasis-and-decreased-survival
#13
Amy R Deipolyi, A John Iafrate, Andrew X Zhu, Emel A Ergul, Suvranu Ganguli, Rahmi Oklu
PURPOSE: To assess how intratumoral shunting relates to liver metastasis and to clinical outcome. MATERIALS AND METHODS: Lung shunt fraction (LSF) was calculated from macroaggregated albumin scan after transcatheter injection of radioactive particles in 62 patients with colorectal cancer and liver metastases evaluated for selective internal radiation therapy (SIRT) from May 2007 to August 2012. Assessment was performed of how LSF, liver tumor burden, and systemic chemotherapy relate to survival and the presence of lung metastases...
October 2014: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/24797128/harnessing-high-density-lipoproteins-to-block-transforming-growth-factor-beta-and-to-inhibit-the-growth-of-liver-tumor-metastases
#14
José Medina-Echeverz, Jessica Fioravanti, Nancy Díaz-Valdés, Kathrin Frank, Fernando Aranda, Celia Gomar, Nuria Ardaiz, Javier Dotor, Viktor Umansky, Jesús Prieto, Pedro Berraondo
Transforming growth factor β (TGF-β) is a powerful promoter of cancer progression and a key target for antitumor therapy. As cancer cells exhibit active cholesterol metabolism, high density lipoproteins (HDLs) appear as an attractive delivery system for anticancer TGFβ-inhibitory molecules. We constructed a plasmid encoding a potent TGF-β-blocking peptide (P144) linked to apolipoprotein A-I (ApoA-I) through a flexible linker (pApoLinkerP144). The ApoLinkerP144 sequence was then incorporated into a hepatotropic adeno-associated vector (AAVApoLinkerP144)...
2014: PloS One
https://www.readbyqxmd.com/read/24625075/t-cells-but-not-nk-cells-are-associated-with-a-favourable-outcome-for-resected-colorectal-liver-metastases
#15
Siân A Pugh, Rebecca J Harrison, John N Primrose, Salim I Khakoo
BACKGROUND: The adaptive immune response to colorectal cancer is important for survival. Less is understood about the role of innate lymphocytes, such as Natural Killer (NK) cells, which are abundant in human liver. METHODS: Samples of fresh liver (n = 21) and tumour (n = 11) tissue were obtained from patients undergoing surgical resection of colorectal liver metastases. Flow cytometry was used to analyse the presence and phenotype of NK cells, as compared to T cells, in the tumour and liver tissue...
2014: BMC Cancer
https://www.readbyqxmd.com/read/24509211/circulating-tumor-cells-in-patients-with-colorectal-liver-metastasis-predict-impaired-survival
#16
Lars Thomas Seeberg, Anne Waage, Cathrine Brunborg, Harald Hugenschmidt, Anne Renolen, Ingun Stav, Bjørn Atle Bjørnbeth, Kristoffer W Brudvik, Elin F Borgen, Bjørn Naume, Gro Wiedswang
OBJECTIVE: The aim of the study is to assess the prognostic and predictive value of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in bone marrow (BM) in patients with colorectal liver metastasis referred to surgery. BACKGROUND: A total of 194 patients were included. Treatment of the patients was decided in a multidisciplinary team. METHODS: BM aspirates and blood samples were collected at surgery, or in local anesthesia in nonresectable patients...
January 2015: Annals of Surgery
https://www.readbyqxmd.com/read/24363829/surgery-for-colorectal-liver-metastases-the-evolution-of-determining-prognosis
#17
REVIEW
Gaya Spolverato, Aslam Ejaz, Nilo Azad, Timothy M Pawlik
Despite improvements in the multi-modality treatment of colorectal liver metastasis (CRLM), survival after resection remains varied. Determining prognosis after surgical resection has historically been predicated on preoperative clinicopathological factors such as primary tumor stage, carcinoembryonic antigen levels, number of liver metastases, presence of extrahepatic disease, as well as other factors. While scoring systems have been developed by combining certain preoperative factors, these have been inconsistent in accurately determining prognosis...
December 15, 2013: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/24334302/apoptotic-circulating-tumor-cells-ctcs-in-the-peripheral-blood-of-metastatic-colorectal-cancer-patients-are-associated-with-liver-metastasis-but-not-ctcs
#18
Joshua E Allen, Bikramajit Singh Saroya, Miriam Kunkel, David T Dicker, Avisnata Das, Kristi L Peters, Jamal Joudeh, Junjia Zhu, Wafik S El-Deiry
Enumeration of circulating tumor cells (CTCs) by the CellSearch system provides prognostic information in metastatic colorectal cancer, regardless of metastatic site. We found that CTCs generally represent <1% of observed events with CellSearch analysis and adapted scoring criteria to classify other peripheral blood events. Examination of twenty two metastatic colorectal cancer patients' blood revealed that patients with high CEA or liver metastases, but not lung or distant lymph node metastases, possessed significant numbers of apoptotic CTCs prior to treatment initiation by Fischer's exact test...
April 15, 2014: Oncotarget
https://www.readbyqxmd.com/read/24153154/circulating-tumor-cells-are-associated-with-diffuse-spread-in-stage-iv-colorectal-cancer-patients
#19
Jussuf T Kaifi, Miriam Kunkel, Junjia Zhu, David T Dicker, Niraj Gusani, Zhaohai Yang, Nabeel E Sarwani, Guangfu Li, Eric T Kimchi, Kevin F Staveley-O'Carroll, Wafik S El-Deiry
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the United States when combining both genders. Circulating tumor cells (CTCs) are a prognostic marker for stage IV CRC patients. We hypothesized that CTC quantity varies among stage IV CRC populations. METHODS: Blood (7.5 ml) was prospectively collected from 90 stage IV CRC patients. EpCAM(+) CTCs were analyzed with the FDA-approved CellSearch(®) system. CRC tumors were immunohistochemically stained for EpCAM expression...
December 2013: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/24025255/janus-faced-kupffer-cells-in-tumor-metastasis
#20
COMMENT
Paul Dent
Kupffer cells are the resident liver macrophages of the liver; other tissues also have resident immune cells e.g., microglia in the brain. These cells have a distinct embryonic lineage when compared with circulating myeloid cells. In both the liver and brain micro-environments activation of their resident immune cells results in the synthesis of multiple growth factors and cytokines which stimulate tumor growth and that in part provide the permissive "soil" in which the tumor "seed" grows. In the manuscript by Wen et al...
October 1, 2013: Cancer Biology & Therapy
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