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BDNF mood disorders

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https://www.readbyqxmd.com/read/29722134/a-novel-pde9-inhibitor-wyq-c36d-ameliorates-corticosterone-induced-neurotoxicity-and-depression-like-behaviors-by-cgmp-creb-related-signaling
#1
Xian-Feng Huang, Wen-Tao Jiang, Li Liu, Fang-Chen Song, Xia Zhu, Gui-Lan Shi, Shu-Ming Ding, Heng-Ming Ke, Wei Wang, James M O'Donnell, Han-Ting Zhang, Hai-Bin Luo, Yi-Qian Wan, Guo-Qiang Song, Ying Xu
BACKGROUND: Major depressive disorder (MDD) is a mental disease characterized by depressed mood, lifetime anxiety, and deficits of learning and memory. Inhibition of phosphodiesterase 9 (PDE9) has been reported to improve rodent cognitive and memory function. However, the role of PDE9 in MDD, in particular its manifestations of depression and anxiety, has not been investigated. METHODS: We examined the protective effects of WYQ-C36D (C36D), a novel PDE9 inhibitor, against corticosterone-induced cytotoxicity, pCREB/CREB and BDNF expression by cell viability, and immunoblot assays in HT-22 cells...
May 2, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29704309/the-neuroprotective-and-antidepressant-like-effects-of-hcyb1-a-novel-selective-pde2-inhibitor
#2
Li Liu, Jing Zheng, Xian-Feng Huang, Xia Zhu, Shu-Ming Ding, Heng-Ming Ke, James M O'Donnell, Han-Ting Zhang, Guo-Qiang Song, Ying Xu
AIMS: Depression is currently the most common mood disorder. Regulation of intracellular cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP) signaling by phosphodiesterase (PDE) inhibition has been paid much attention for treatment of depression. This study aimed to investigate the neuroprotective effects of Hcyb1, a novel PDE2 inhibitor, in HT-22 cells and antidepressant-like effects in mouse models of depression. METHODS: Hcyb1 was synthesized and its selectivity upon PDE2 was tested...
April 27, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29684863/psychological-and-genetic-risk-factors-associated-with-suicidal-behavior-in-korean-patients-with-mood-disorders
#3
Hee-Yeon Choi, Ga Eun Kim, Kyoung Ae Kong, Yu Jin Lee, Weon-Jeong Lim, So-Hyun Park, Su Hee Ha, Soo In Kim
INTRODUCTION: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. METHODS: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404)...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29626566/the-antidepressant-like-effects-of-a-novel-curcumin-derivative-j147-involvement-of-5-ht-1a-receptor
#4
Lejing Lian, Ying Xu, Jianbo Zhang, Yingcong Yu, Naping Zhu, Xiaofei Guan, Hui Huang, Ruijie Chen, Jie Chen, Guilan Shi, Jianchun Pan
Depression is a dysthymia disorder characterized by a pervasive or persistent mental disorder that causes mood, cognitive and memory deficits. J147, a curcumin analogue, increases brain derived neurotrophic factor (BDNF) levels and facilitates memory in animals. Because curcumin has the antidepressant-like activity, the present study investigated the potential antidepressant-like effects of J147 in the forced swimming test (FST) and tail suspension tests (TST) and the involvement of 5-HT receptors related to cAMP signaling...
April 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29592951/bdnf-signaling-harnessing-stress-to-battle-mood-disorder
#5
Pawel Licznerski, Elizabeth A Jonas
No abstract text is available yet for this article.
March 28, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29464752/voluntary-wheel-running-attenuates-urinary-bladder-hypersensitivity-and-dysfunction-following-neonatal-maternal-separation-in-female-mice
#6
Angela N Pierce, Olivia C Eller-Smith, Julie A Christianson
AIMS: Patients with interstitial cystitis/painful bladder syndrome (IC/PBS) commonly suffer from widespread pain and mood disorder, which has been attributed to improper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Voluntary exercise has been shown to improve HPA axis function, therefore we are determining whether voluntary wheel running can attenuate urological pain and dysfunction following neonatal maternal separation (NMS) in female mice. METHODS: Mice underwent NMS for 3 h/day from postnatal Day 1-21, were caged with free access to running wheels at 4 weeks of age, and assessed 4 weeks later for bladder sensitivity, micturition, reward behavior, mast cell degranulation, and HPA axis-related in vitro analysis...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29463911/disruption-of-lipid-raft-localized-g%C3%AE-s-tubulin-complexes-by-antidepressants-a-unique-feature-of-hdac6-inhibitors-ssri-and-tricyclic-compounds
#7
Harinder Singh, Nathan Wray, Jeffrey M Schappi, Mark M Rasenick
Current antidepressant therapies meet with variable therapeutic success and there is increasing interest in therapeutic approaches not based on monoamine signaling. Histone deacetylase 6 (HDAC6), which also deacetylates α-tubulin shows altered expression in mood disorders and HDAC6 knockout mice mimic traditional antidepressant treatments. Nonetheless, a mechanistic understanding for HDAC6 inhibitors in the treatment of depression remains elusive. Previously, we have shown that sustained treatment of rats or glioma cells with several antidepressants translocates Gαs from lipid rafts toward increased association with adenylyl cyclase (AC)...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29460712/rhythmic-low-field-magnetic-stimulation-may-improve-depression-by-increasing-brain-derived-neurotrophic-factor
#8
Le Xiao, Christoph U Correll, Lei Feng, Yu-Tao Xiang, Yuan Feng, Chang-Qing Hu, Rena Li, Gang Wang
BACKGROUND: Low-field magnetic stimulation (LFMS) has mood-elevating effect, and the increase of brain-derived neurotrophic factor (BDNF) is associated with antidepressant treatment. We evaluated the effects and association with BDNF of rhythmic LFMS in the treatment of major depressive disorder (MDD). METHODS: A total of 22 MDD patients were randomized to rhythmic alpha stimulation (RAS) or rhythmic delta stimulation (RDS), with 5 sessions per week, lasting for 6 weeks...
February 20, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29459824/-egr3-immediate-early-gene-and-the-brain-derived-neurotrophic-factor-in-bipolar-disorder
#9
Bianca Pfaffenseller, Flavio Kapczinski, Amelia L Gallitano, Fábio Klamt
Bipolar disorder (BD) is a severe psychiatric illness with a consistent genetic influence, involving complex interactions between numerous genes and environmental factors. Immediate early genes (IEGs) are activated in the brain in response to environmental stimuli, such as stress. The potential to translate environmental stimuli into long-term changes in brain has led to increased interest in a potential role for these genes influencing risk for psychiatric disorders. Our recent finding using network-based approach has shown that the regulatory unit of early growth response gene 3 ( EGR3 ) of IEGs family was robustly repressed in postmortem prefrontal cortex of BD patients...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29438801/specific-activity-features-in-the-forced-swim-test-brain-neurotrophins-and-development-of-stress-induced-depressive-like-behavior-in-rats
#10
Mikhail Stepanichev, Anna Manolova, Danil Peregud, Mikhail Onufriev, Sofia Freiman, Viktor Aniol, Yulia Moiseeva, Margarita Novikova, Natalia Lazareva, Natalia Gulyaeva
Selective vulnerability or resilience to mood disorders is related to individual differences or personality. In the present study forced swim test (FST) was used as a tool for division of male rats according to their immobility behavior. The animals were subjected to a chronic unpredictable mild stress (CUS). Depressive-like behavior and modifications in brain neurotrophin system of were examined after CUS exposure. The low immobile (LI) and high immobile (HI) rats demonstrated elusive differences in expression of BDNF ExVI mRNA and TrkA mRNA which was higher in the hippocampus and frontal cortex, respectively, of HI rats as compared to LI animals...
April 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29388082/brain-derived-neurotrophic-factor-prevents-depressive-like-behaviors-in-early-symptomatic-yac128-huntington-s-disease-mice
#11
Victor Silva da Fonsêca, André R da Silva Colla, Cristine de Paula Nascimento-Castro, Evelini Plácido, Julia Macedo Rosa, Marcelo Farina, Joana Gil-Mohapel, Ana Lúcia S Rodrigues, Patricia S Brocardo
Huntington disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the Huntington disease gene. The symptomatic stage of the disease is defined by the onset of motor symptoms. However, psychiatric disturbances, including depression, are common features of HD and can occur a decade before the manifestation of motor symptoms. We used the YAC128 transgenic mice (which develop motor deficits at a later stage, allowing more time to study depressive behaviors without the confounding effects of motor impairment) to test the effects of intranasal brain-derived neurotrophic factor (BDNF) treatment for 15 days in the occurrence of depressive-like behaviors...
January 31, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29348904/role-of-tissue-type-plasminogen-activator-and-plasminogen-activator-inhibitor-1-in-psychological-stress-and-depression
#12
REVIEW
Shih-Jen Tsai
Major depressive disorder is a common illness worldwide, but the pathogenesis of the disorder remains incompletely understood. The tissue-type plasminogen activator-plasminogen proteolytic cascade is highly expressed in the brain regions involved in mood regulation and neuroplasticity. Accumulating evidence from animal and human studies suggests that tissue-type plasminogen activator and its chief inhibitor, plasminogen activator inhibitor-1, are related to stress reaction and depression. Furthermore, the neurotrophic hypothesis of depression postulates that compromised neurotrophin brain-derived neurotrophic factor (BDNF) function is directly involved in the pathophysiology of depression...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29332095/both-serum-brain-derived-neurotrophic-factor-and-interleukin-6-levels-are-not-associated-with-therapeutic-response-to-lamotrigine-augmentation-therapy-in-treatment-resistant-depressive-disorder
#13
Shoko Kagawa, Kazuo Mihara, Takeshi Suzuki, Goyo Nagai, Akifumi Nakamura, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation therapy in 46 (15 males and 31 females) inpatients with treatment-resistant depressive disorder during an 8-week treatment with lamotrigine using an open-study design. METHODS: The subjects were 46 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29331712/genetic-biomarkers-for-differential-diagnosis-of-major-depressive-disorder-and-bipolar-disorder-a-systematic-and-critical-review
#14
REVIEW
Itiana Castro Menezes, Cristiane von Werne Baes, Riccardo Lacchini, Mario Francisco Juruena
Depressive symptoms are present in the depressive mood state of bipolar disorder (BPD) and major depression disorder (MDD). Often, in clinical practice, BPD patients are misdiagnosed with MDD. Therefore, genetic biomarkers could contribute to the improvement of differential diagnosis between BPD and MDD. This systematic and critical review aimed to find in literature reliable genetic biomarkers that may show differences between BPD and MDD. This systematic review followed the PRISMA-P method. The terms used to search PubMed, Scopus, PsycINFO, and Web of Science were depress*, bipolar, diagnos*, genetic*, biomark*...
January 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29243873/a-comprehensive-review-of-genetic-and-epigenetic-mechanisms-that-regulate-bdnf-expression-and-function-with-relevance-to-major-depressive-disorder
#15
REVIEW
Benjamin Hing, Leela Sathyaputri, James B Potash
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs cognition. A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is involved in processes controlling neuroplasticity. Various mechanisms exist to regulate BDNF's expression level, subcellular localization, and sorting to appropriate secretory pathways. Alterations to these processes by genetic factors and negative stressors can dysregulate its expression, with possible implications for MDD...
March 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29158584/ketamine-enhances-structural-plasticity-in-mouse-mesencephalic-and-human-ipsc-derived-dopaminergic-neurons-via-ampar-driven-bdnf-and-mtor-signaling
#16
L Cavalleri, E Merlo Pich, M J Millan, C Chiamulera, T Kunath, P F Spano, G Collo
Among neurobiological mechanisms underlying antidepressant properties of ketamine, structural remodeling of prefrontal and hippocampal neurons has been proposed as critical. The suggested mechanism involves downstream activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which trigger mammalian target of rapamycin (mTOR)-dependent structural plasticity via brain-derived neurotrophic factor (BDNF) and protein neo-synthesis. We evaluated whether ketamine elicits similar molecular events in dopaminergic (DA) neurons, known to be affected in mood disorders, using a novel, translational strategy that involved mouse mesencephalic and human induced pluripotent stem cells-derived DA neurons...
April 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29141007/escitalopram-and-nht-normalized-stress-induced-anhedonia-and-molecular-neuroadaptations-in-a-mouse-model-of-depression
#17
Or Burstein, Motty Franko, Eyal Gale, Assaf Handelsman, Segev Barak, Shai Motsan, Alon Shamir, Roni Toledano, Omri Simhon, Yafit Hirshler, Gang Chen, Ravid Doron
Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive stimuli. Anxiety and mood disorders have been previously associated with dysregulation of the reward system, with anhedonia as a core element of major depressive disorder (MDD). The aim of the present study was to investigate whether stress-induced anhedonia could be prevented by treatments with escitalopram or novel herbal treatment (NHT) in an animal model of depression. Unpredictable chronic mild stress (UCMS) was administered for 4 weeks on ICR outbred mice...
2017: PloS One
https://www.readbyqxmd.com/read/29101600/normal-diet-vs-high-fat-diet-a-comparative-study-behavioral-and-neuroimmunological-changes-in-adolescent-male-mice
#18
Huali Wu, Qiongzhen Liu, Praveen Kumar Kalavagunta, Qiaoling Huang, Wenting Lv, Xiaohong An, Haijuan Chen, Tao Wang, Rakotomalala Manda Heriniaina, Tong Qiao, Jing Shang
Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolescence, which is important period for shaping learning/memory and mood regulation that can be sensitive to the detrimental effects of HFD. Our present study is focused to investigate behavioral and metabolic influences of short-term HFD intake in adolescent C57BL/6 mice...
February 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29075579/expression-of-bdnf-and-trkb-in-the-hippocampus-of-a-rat-genetic-model-of-vulnerability-roman-low-avoidance-and-resistance-roman-high-avoidance-to-stress-induced-depression
#19
M Pina Serra, Laura Poddighe, Marianna Boi, Francesco Sanna, M Antonietta Piludu, M Giuseppa Corda, Osvaldo Giorgi, Marina Quartu
INTRODUCTION: The selective breeding of Roman High- (RHA) and Low-Avoidance (RLA) rats for, respectively, rapid versus poor acquisition of the active avoidance response has generated two distinct phenotypes differing in many behavioral traits, including coping strategies to aversive conditions. Thus, RLA rats are considered as a genetic model of vulnerability to stress-induced depression whereas RHA rats are a model of resilience to that trait. Besides the monoamine hypothesis of depression, there is evidence that alterations in neuronal plasticity in the hippocampus and other brain areas are critically involved in the pathophysiology of mood disorders...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29075536/neural-plasticity-associated-with-hippocampal-pka-creb-and-nmda-signaling-is-involved-in-the-antidepressant-effect-of-repeated-low-dose-of-yueju-pill-on-chronic-mouse-model-of-learned-helplessness
#20
Zhilu Zou, Yin Chen, Qinqin Shen, Xiaoyan Guo, Yuxuan Zhang, Gang Chen
Yueju pill is a traditional Chinese medicine formulated to treat syndromes of mood disorders. Here, we investigated the therapeutic effect of repeated low dose of Yueju in the animal model mimicking clinical long-term depression condition and the role of neural plasticity associated with PKA- (protein kinase A-) CREB (cAMP response element binding protein) and NMDA (N-methyl-D-aspartate) signaling. We showed that a single low dose of Yueju demonstrated antidepressant effects in tests of tail suspension, forced swim, and novelty-suppressed feeding...
2017: Neural Plasticity
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