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BDNF mood disorders

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https://www.readbyqxmd.com/read/28093238/a-model-of-the-mitochondrial-basis-of-bipolar-disorder
#1
REVIEW
Gerwyn Morris, Ken Walder, Sean L McGee, Olivia M Dean, Susannah J Tye, Michael Maes, Michael Berk
BACKGROUND: Bipolar disorder phenomenologically is a biphasic disorder of energy availability; increased in mania and decreased in depression. In consort, there is accumulating evidence indicating increased mitochondrial respiration and ATP production in bipolar mania which contrasts with decreased mitochondrial function in patients in the euthymic or depressive phase of the illness. Consequently, the central thesis of this paper is that bipolar disorder is due to a phasic dysregulation of mitochondrial biogenergetics...
January 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28092086/anxiety-related-behaviours-associated-with-microrna-206-3p-and-bdnf-expression-in-pregnant-female-mice-following-psychological-social-stress
#2
Zhuang Miao, Fengbiao Mao, Jialong Liang, Moshe Szyf, Yan Wang, Zhong Sheng Sun
Stress during pregnancy can induce various psychological disorders in women. However, the association linking psychological stress during pregnancy with abnormal behaviours in females remains largely unknown. We employed a novel psychological stress model by introducing pregnant mice to witness the defeat process of their mated partner (WDPMP) and examined the effects of WDPMP on depression-/anxiety-like behaviours and on the expression of brain-derived neurotrophic factor (BDNF) and miR-206-3p in the hippocampus, medial prefrontal cortex (mPFC) and amygdala...
January 14, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28078988/bdnf-nf-kb-signaling-in-the-neurobiology-of-depression
#3
Ariel Caviedes, Carlos Lafourcade, Claudio Soto, Ursula Wyneken
BACKGROUND: Mood disorders, consisting of unipolar and bipolar depression, are complex diseases characterized by depressed mood and anhedonia. These core symptoms are accompanied in a varying manner by anxiety, several neurovegetative symptoms and cognitive impairment. Mood disorders are characterized by decreases in neurogenesis, alteration in synaptic structure and synaptic transmission, all of them regulated by BDNF, a neurotrophin that performs multiple functions in the adult central nervous system...
January 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27988398/control-of-stress-induced-depressive-disorders-by-so-ochim-tang-gamibang-a-korean-herbal-medicine
#4
Jung Eun Choi, Dae-Myung Park, Eunho Chun, Jeong June Choi, Ji Hye Seo, Seunghyung Kim, Jaemin Son, Moonho Do, Sun Yeou Kim, Yang-Chun Park, In Chul Jung, Mirim Jin
ETHNOPHARMACOLOGICAL RELEVANCE: So-ochim-tang-gamibang (SOCG) is a Korean herbal medicine formula that has been applied to treat depressive moods and depression associated somatoform pain. This decoction consists of Cyperus rotundus L. (Cyperi Rhizoma), Lindera aggregata (Sims) Kosterm. (Linderae Radix), Aquilaria agallochum (Lour.) Roxb. ex Finl. (Aquilariae Resinatum Lignum), Glycyrrhiza uralensis Fisch. (Glycyrrhizae Radix) Platycodon grandiflorum (Jacq.) A. DC. (Platycodi Radix), and Citrus aurantium L...
January 20, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27959329/brain-derived-neurotrophic-factor-increase-during-treatment-in-severe-mental-illness-inpatients
#5
G L Nuernberg, B Aguiar, G Bristot, M P Fleck, N S Rocha
Meta-analytical evidence suggests that brain-derived neurotrophic factor (BDNF) is altered in various psychiatric disorders. However, meta-analyses may be hampered by the heterogeneity of BDNF assays, lack of BDNF standard values and heterogeneity among the populations included in the studies. To address these issues, our study aimed to test, in a 'true-to-life' setting, the hypothesis that the serum BDNF level is nonspecifically reduced in acute severe mental illness (SMI) patients and increases during inpatient treatment...
December 13, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27956743/translational-profiling-of-stress-induced-neuroplasticity-in-the-ca3-pyramidal-neurons-of-bdnf-val66met-mice
#6
J D Gray, T G Rubin, J F Kogan, J Marrocco, J Weidmann, S Lindkvist, F S Lee, E F Schmidt, B S McEwen
Genetic susceptibility and environmental factors (such as stress) can interact to affect the likelihood of developing a mood disorder. Stress-induced changes in the hippocampus have been implicated in mood disorders, and mutations in several genes have now been associated with increased risk, such as brain-derived neurotrophic factor (BDNF). The hippocampus has important anatomical subdivisions, and pyramidal neurons of the vulnerable CA3 region show significant remodeling after chronic stress, but the mechanisms underlying their unique plasticity remain unknown...
December 13, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27793269/brain-derived-neurotrophic-factor-protein-and-mrna-levels-in-patients-with-bipolar-mania-a-preliminary-study
#7
Chin-Chuen Lin, Chien-Te Lee, Ya-Ting Lo, Tiao-Lai Huang
BACKGROUND: Brain-derived neurotrophic factor (BDNF) protein or mRNA levels may be involved in the pathophysiology of bipolar disorder. However, the results were inconsistent. We aimed to simultaneously investigate the relationship of BDNF protein and mRNA levels in peripheral blood of patients with bipolar mania. METHODS: Patients with bipolar mania (n = 30) and healthy controls (n = 30) were recruited during our one-year study. Psychiatric diagnoses were made according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria...
August 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27757074/effects-of-duloxetine-treatment-on-cognitive-flexibility-and-bdnf-expression-in-the-mpfc-of-adult-male-mice-exposed-to-social-stress-during-adolescence
#8
Hang Xu, Yu Zhang, Fan Zhang, San-Na Yuan, Feng Shao, Weiwen Wang
Early stress is a significant risk factor for the onset of mood disorders such as depression during adulthood. Impairments in cognitive flexibility mediated by prefrontal cortex (PFC) dysfunction are increasingly recognized as important etiological and pathological factors in the development of depression. Our previous study demonstrated that social defeat stress during early adolescence produced delayed deficits in cognitive flexibility in adult mice. The potential molecular mechanisms underlying these long-term consequences remain unclear...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27699937/the-role-of-bdnf-in-the-development-of-fear-learning
#9
Iva Dincheva, Niccola B Lynch, Francis S Lee
Brain-derived neurotrophic factor (BDNF) is a growth factor that is dynamically expressed in the brain across postnatal development, regulating neuronal differentiation and synaptic plasticity. The neurotrophic hypothesis of psychiatric mood disorders postulates that in the adult brain, decreased BDNF levels leads to altered neural plasticity, contributing to disease. Although BDNF has been established as a key factor regulating the critical period plasticity in the developing visual system, it has recently been shown to also play a role in fear circuitry maturation, which has implications for the emergence of fear-related mood disorders...
October 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27697714/relationships-between-serum-bdnf-and-the-antidepressant-effect-of-acute-exercise-in-depressed-women
#10
Jacob D Meyer, Kelli F Koltyn, Aaron J Stegner, Jee-Seon Kim, Dane B Cook
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has recently emerged as one potential mechanism with which exercise improves mood in major depressive disorder (MDD). This study examined the relationship between changes in serum total BDNF and mood following acute exercise in MDD. It was hypothesized that acute exercise would increase BDNF in an intensity-dependent manner and that changes in BDNF would be significantly related to improvement in depressed mood post-exercise. METHODS: Twenty-four women (age: 38...
December 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27697135/risk-impact-of-having-a-first-degree-relative-with-affective-disorder-a-7-year-follow-up-study
#11
Maj Vinberg
This study investigated a high-risk sample in order to elucidate risk factors for affective disorder. Healthy monozygotic (MZ) and dizygotic (DZ) twins with and without a co-twin with a history of affective disorder were identified through nationwide registers. Two risk groups were identified: the high-risk group comprised twins at risk of developing affective disorder (DZ or MZ twin; index co-twin affected); the low risk group (control group) comprised twins at low risk of developing affective disorder (DZ or MZ twin; index co-twin not affected)...
October 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27660699/sex-related-factors-influence-expression-of-mood-related-genes-in-the-basolateral-amygdala-differentially-depending-on-age-and-stress-exposure
#12
Rachel Puralewski, Georgia Vasilakis, Marianne L Seney
BACKGROUND: Women are twice as likely to be diagnosed with major depressive disorder (MDD) compared to men, but the molecular mechanisms underlying this sex difference are unclear. Previous studies in the human postmortem brain suggest dysfunction in basolateral amygdala (BLA) inhibitory gamma-aminobutyric acid (GABA) signaling and brain-derived neurotrophic factor (BDNF) function, specifically in females with MDD. METHODS: We investigated the effects of sex chromosome complement, developmental gonadal sex, and circulating testosterone on expression of 3 GABA-related and 2 BDNF-related genes in the BLA using three cohorts of four core genotypes (FCG) mice...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27618303/growth-factors-as-clinical-biomarkers-of-prognosis-and-diagnosis-in-psychiatric-disorders
#13
Alma Y Galvez-Contreras, Tania Campos-Ordonez, Veronica Lopez-Virgen, Jesus Gomez-Plascencia, Rodrigo Ramos-Zuniga, Oscar Gonzalez-Perez
The psychiatric disorders are one of the most disabling illnesses in the world and represent a major problem for public health. These disorders are characterized by neuroanatomical or biochemical changes and it has been suggested that such changes may be due to inadequate neurodevelopment. Diverse alterations in the gene expression and/or serum level of specific growth factors have been implicated in the etiology, symptoms and progression of some psychiatric disorders. Herein, we summarize the latest information regarding the role of brain-derived neurotrophic factor (BDNF), epidermal growth factor (EGF), fibroblast growth factor (FGF), Insulin-like growth factor (IGF-1), neuroregulin-1 (NGR-1), erythropoietin (EPO), vascular growth factor (VEGF), transforming growth factor beta (TGF-β), nerve growth factor (NGF) and others cytokines in the pathogenesis of schizophrenia, depression, bipolar and anxiety disorders...
December 2016: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/27598965/anxiety-and-depression-with-neurogenesis-defects-in-exchange-protein-directly-activated-by-camp-2-deficient-mice-are-ameliorated-by-a-selective-serotonin-reuptake-inhibitor-prozac
#14
L Zhou, S L Ma, P K K Yeung, Y H Wong, K W K Tsim, K F So, L C W Lam, S K Chung
Intracellular cAMP and serotonin are important modulators of anxiety and depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). However, the role of Epac1 and Epac2 (Rap guanine nucleotide exchange factors, RAPGEF3 and RAPGEF4, respectively) as potential downstream targets of SSRI/cAMP in mood regulations is not yet clear...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27501182/type-2-deiodinase-disruption-in-astrocytes-results-in-anxiety-depressive-like-behavior-in-male-mice
#15
Barbara M L C Bocco, João Pedro Werneck-de-Castro, Kelen C Oliveira, Gustavo W Fernandes, Tatiana L Fonseca, Bruna P P Nascimento, Elizabeth A McAninch, Esther Ricci, Zsuzsanna Kvárta-Papp, Csaba Fekete, Maria Martha Bernardi, Balázs Gereben, Antonio C Bianco, Miriam O Ribeiro
Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the type 2 deiodinase (D2)-mediated T4-to-T3 conversion, given their much greater dependence on the D2 pathway for T3 production. T3 normally reaches the brain directly from the circulation or is produced locally by D2 in astrocytes. Here we report that mice with astrocyte-specific Dio2 inactivation (Astro-D2KO) have normal serum T3 but exhibit anxiety-depression-like behavior as found in open field and elevated plus maze studies and when tested for depression using the tail-suspension and the forced-swimming tests...
September 2016: Endocrinology
https://www.readbyqxmd.com/read/27425886/brain-derived-neurotrophic-factor-in-mood-disorders-and-antidepressant-treatments
#16
REVIEW
Eero Castrén, Masami Kojima
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings have shown that posttranslational processing of BDNF gene product can yield different molecular entities that differently influence signaling through BNDF receptor TrkB and the pan-neurotrophin receptor p75(NTR)...
January 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/27404284/involvement-of-the-agmatinergic-system-in-the-depressive-like-phenotype-of-the-crtc1-knockout-mouse-model-of-depression
#17
E M Meylan, L Breuillaud, T Seredenina, P J Magistretti, O Halfon, R Luthi-Carter, J-R Cardinaux
Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood disorder patients. We have previously shown that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) associate behavioral and molecular depressive-like endophenotypes, as well as blunted responses to classical antidepressants. Here, the molecular basis of the behavioral phenotype of Crtc1(-/-) mice was further examined using microarray gene expression profiling that revealed an upregulation of Agmat in the cortex of Crtc1(-/-) mice...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27387295/psychobiological-responses-to-preferred-and-prescribed-intensity-exercise-in-mdd
#18
Jacob D Meyer, Laura D Ellingson, Kelli F Koltyn, Aaron J Stegner, Jee-Seon Kim, Dane B Cook
: Exercise acutely improves mood in major depressive disorder (MDD). However, it is unknown whether benefits differ depending on whether exercise intensity is self-selected or prescribed. PURPOSE: To compare psychological and biological responses to preferred and prescribed steady-state exercise intensities to a patient-selected preferred intensity. METHOD: Female adults (n = 24, age = 38.6 ± 14.0) diagnosed with MDD completed four, 30-minute session of cycling exercise at three prescribed intensities (rating of perceived exertion [RPE] of 11, 13, 15), and one session with a self-selected intensity (preferred)...
July 6, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27324989/brain-derived-neurotrophic-factor-impaired-glucose-metabolism-and-bipolar-disorder-course
#19
Rodrigo B Mansur, Camila M Santos, Lucas B Rizzo, Elson Asevedo, Graccielle R Cunha, Mariane N Noto, Mariana Pedrini, Maiara Zeni-Graiff, Quirino Cordeiro, Maj Vinberg, Flavio Kapczinski, Roger S McIntyre, Elisa Brietzke
OBJECTIVES: The neurotrophin brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker in bipolar disorder (BD). However, current evidence is limited and results have been highly heterogeneous. This study aimed to assess the moderating effect of impaired glucose metabolism (IGM) on plasma levels of BDNF in individuals with BD, and on the relationship between BDNF and variables of illness course. METHODS: We measured and compared the plasma levels of BDNF in individuals with BD (n=57) and healthy controls (n=26)...
June 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27312407/probdnf-signaling-regulates-depression-like-behaviors-in-rodents-under-chronic-stress
#20
Yin-Yin Bai, Chun-Sheng Ruan, Chun-Rui Yang, Jia-Yi Li, Zhi-Long Kang, Li Zhou, Dennis Liu, Yue-Qing Zeng, Ting-Hua Wang, Chang-Fu Tian, Hong Liao, Larisa Bobrovskaya, Xin-Fu Zhou
Chronic exposure to stressful environment is a key risk factor contributing to the development of depression. However, the mechanisms involved in this process are still unclear. Brain-derived neurotropic factor (BDNF) has long been investigated for its positive role in regulation of mood, although the role of its precursor, proBDNF, in regulation of mood is not known. In this study, using an unpredictable chronic mild stress (UCMS) paradigm we found that the protein levels of proBDNF were increased in the neocortex and hippocampus of stressed mice and this UCMS-induced upregulation of proBDNF was abolished by chronic administration of fluoxetine...
November 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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