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Neuroplasticity mood disorders

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https://www.readbyqxmd.com/read/29737454/targeting-%C3%AE-catenin-in-glast-expressing-cells-impact-on-anxiety-and-depression-related-behavior-and-hippocampal-proliferation
#1
Rebeca Vidal, Emilio Garro-Martínez, Álvaro Díaz, Elena Castro, Eva Florensa-Zanuy, Makoto M Taketo, Ángel Pazos, Fuencisla Pilar-Cuéllar
β-catenin (key mediator in the Wnt signaling pathway) contributes to the pathophysiology of mood disorders, associated to neurogenesis and neuroplasticity. Decreased β-catenin protein levels have been observed in the hippocampus and prefrontal cortex of depressed subjects. Additionally, the antidepressants exert, at least in part, their neurogenic effects by increasing β-catenin levels in the subgranular zone of the hippocampus. To further understand the role of β-catenin in depression and anxiety, we generated two conditional transgenic mice in which β-catenin was either inactivated or stabilized in cells expressing CreERT under the control of the astrocyte-specific glutamate transporter (GLAST) promoter inducible by tamoxifen, which presents high expression levels on the subgranular zone of the hippocampus...
May 8, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29673379/erythropoietin-as-an-add-on-treatment-for-cognitive-side-effects-of-electroconvulsive-therapy-a-study-protocol-for-a-randomized-controlled-trial
#2
Lejla Sjanic Schmidt, Jeff Zarp Petersen, Maj Vinberg, Ida Hageman, Niels Vidiendal Olsen, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak
BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe depression, but its use is impeded by its cognitive side effects. Novel treatments that can counteract these side effects may therefore improve current treatment strategies for depression. The present randomized trial investigates (1) whether short-term add-on treatment with erythropoietin (EPO) can reduce the cognitive side -effects of ECT and (2) whether such effects are long-lasting. Further, structural and functional magnetic resonance imaging (MRI) will be used to explore the neural underpinnings of such beneficial effects of EPO...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29512136/circadian-modulation-of-neuroplasticity-by-melatonin-a-target-in-the-treatment-of-depression
#3
REVIEW
Marcela Valdés-Tovar, Rosa Estrada-Reyes, Héctor Solís-Chagoyán, Jesús Argueta, Ana María Dorantes-Barrón, Daniel Quero-Chávez, Ricardo Cruz-Garduño, Montserrat G Cercós, Citlali Trueta, Julián Oikawa-Sala, Margarita L Dubocovich, Gloria Benítez-King
Mood disorders are a spectrum of neuropsychiatric disorders characterized by changes in the emotional state. In particular, major depressive disorder is expected to have a worldwide prevalence of 20% in 2020, representing a huge socio-economic burden. Currently used antidepressant drugs have poor efficacy with only 30% of the patients in remission after the first line of treatment. Importantly, mood disorder patients present uncoupling of circadian rhythms. In this regard, melatonin (5-methoxy-N-acetyltryptamine), an indolamine synthesized by the pineal gland during the night, contributes to synchronization of body rhythms with the environmental light/dark cycle...
March 7, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29348904/role-of-tissue-type-plasminogen-activator-and-plasminogen-activator-inhibitor-1-in-psychological-stress-and-depression
#4
REVIEW
Shih-Jen Tsai
Major depressive disorder is a common illness worldwide, but the pathogenesis of the disorder remains incompletely understood. The tissue-type plasminogen activator-plasminogen proteolytic cascade is highly expressed in the brain regions involved in mood regulation and neuroplasticity. Accumulating evidence from animal and human studies suggests that tissue-type plasminogen activator and its chief inhibitor, plasminogen activator inhibitor-1, are related to stress reaction and depression. Furthermore, the neurotrophic hypothesis of depression postulates that compromised neurotrophin brain-derived neurotrophic factor (BDNF) function is directly involved in the pathophysiology of depression...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243873/a-comprehensive-review-of-genetic-and-epigenetic-mechanisms-that-regulate-bdnf-expression-and-function-with-relevance-to-major-depressive-disorder
#5
REVIEW
Benjamin Hing, Leela Sathyaputri, James B Potash
Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs cognition. A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is involved in processes controlling neuroplasticity. Various mechanisms exist to regulate BDNF's expression level, subcellular localization, and sorting to appropriate secretory pathways. Alterations to these processes by genetic factors and negative stressors can dysregulate its expression, with possible implications for MDD...
March 2018: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/29214080/hint1-in-neuropsychiatric-diseases-a-potential-neuroplastic-mediator
#6
REVIEW
Peng Liu, Zhongwei Liu, Jiabei Wang, Xiancang Ma, Yonghui Dang
Although many studies have investigated the functions of histidine triad nucleotide-binding protein 1 (HINT1), its roles in neurobiological processes remain to be fully elucidated. As a member of the histidine triad (HIT) enzyme superfamily, HINT1 is distributed in almost every organ and has both enzymatic and nonenzymatic activity. Accumulating clinical and preclinical evidence suggests that HINT1 may play an important role as a neuroplastic mediator in neuropsychiatric diseases, such as schizophrenia, inherited peripheral neuropathies, mood disorders, and drug addiction...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/29166690/-facial-emotion-recognition-theory-of-mind-and-empathy-in-multiple-sclerosis
#7
Samar S Ayache, Moussa A Chalah, Tania Kuempfel, Frank Padberg, Jean-Pascal Lefaucheur, Ulrich Palm
Multiple sclerosis (MS), a chronic progressive inflammatory disease of the central nervous system, causes frequent disability, mood disorders, fatigue, and cognitive dysfunction. As a part of the last, social cognition is frequently disturbed in MS patients. It comprises empathy and social perception of emotions from facial, bodily and vocal cues. Social cognitive deficits worsen affect decoding, interpersonal relationship, and quality of life. Despite the impact of these deficits on global functioning, only a small number of studies have investigated its correlations and overlaps with MS symptoms...
November 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/29079138/a-homer-1-gene-variant-influences-brain-structure-and-function-lithium-effects-on-white-matter-and-antidepressant-response-in-bipolar-disorder-a-multimodal-genetic-imaging-study
#8
Francesco Benedetti, Sara Poletti, Clara Locatelli, Elena Mazza, Cristina Lorenzi, Alice Vitali, Martina Riberto, Silvia Brioschi, Benedetta Vai, Irene Bollettini, Elisa Melloni, Veronica Aggio, Andrea Falini, Andrea De Bartolomeis, Cristina Colombo
BACKGROUND: The Homer family of postsynaptic scaffolding proteins plays a crucial role in glutamate-mediated synaptic plasticity, a phenotype associated with Bipolar Disorder (BD). Homer is a target for antidepressants and mood stabilizers. The AA risk genotype of the Homer rs7713917 A>G SNP has been associated with mood disorders and suicide, and in healthy humans with brain function. Despite the evidence linking Homer 1 gene and function to mood disorder, as well as its involvement in animal models of depression, no study has yet investigated the role of Homer in bipolar depression and treatment response...
February 2, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28828187/exercise-promotes-neuroplasticity-in-both-healthy-and-depressed-brains-an-fmri-pilot-study
#9
Joanne Gourgouvelis, Paul Yielder, Bernadette Murphy
Memory impairments are a frequently reported cognitive symptom in people suffering from major depressive disorder (MDD) and often persist despite antidepressant therapy. Neuroimaging studies have identified abnormal hippocampal activity during memory processes in MDD. Exercise as an ad-on treatment for MDD is a promising therapeutic strategy shown to improve mood, cognitive function, and neural structure and function. To advance our understanding of how exercise impacts neural function in MDD, we must also understand how exercise impacts healthy individuals without MDD...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28717522/effect-of-hypoxic-injury-in-mood-disorder
#10
REVIEW
Fenglian Zhao, Junling Yang, Ranji Cui
Hypoxemia is a common complication of the diseases associated with the central nervous system, and neurons are highly sensitive to the availability of oxygen. Neuroplasticity is an important property of the neural system controlling breathing, memory, and cognitive ability. However, the underlying mechanism has not yet been clearly elucidated. In recent years, several pieces of evidence have highlighted the effect of hypoxic injury on neuronal plasticity in the pathogenesis and treatment of mood disorder. Therefore, the present study reviewed the relevant articles regarding hypoxic injury and neuronal plasticity and discussed the pathological changes and physiological functions of neurons in hypoxemia in order to provide a translational perspective to the relevance of hypoxic injury and mood disorder...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28711724/neurotrophic-and-inflammatory-markers-in-bipolar-disorder-a-prospective-study
#11
Seline van den Ameele, Violette Coppens, Jeroen Schuermans, Peter De Boer, Maarten Timmers, Erik Fransen, Bernard Sabbe, Manuel Morrens
Altered neurotrophic signaling is thought to impair neuroplasticity in bipolar disorder (BD). Brain-derived neurotrophic factor (BDNF) is proposed as a neurotrophic marker in BD. However, the current evidence for its use in monitoring disease activity and illness progression is conflicting and an exploration of additional neurotrophic markers is needed. This prospective case-control study investigated mood-specific changes in potential neurotrophic markers and their association to inflammatory activity. Patients with BD were included during an acute mood episode, either depressive (n=35) or (hypo)manic (n=32)...
July 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28638351/transcranial-direct-current-stimulation-considerations-for-research-in-adolescent-depression
#12
REVIEW
Jonathan C Lee, Charles P Lewis, Zafiris J Daskalakis, Paul E Croarkin
Adolescent depression is a prevalent disorder with substantial morbidity and mortality. Current treatment interventions do not target relevant pathophysiology and are frequently ineffective, thereby leading to a substantial burden for individuals, families, and society. During adolescence, the prefrontal cortex undergoes extensive structural and functional changes. Recent work suggests that frontolimbic development in depressed adolescents is delayed or aberrant. The judicious application of non-invasive brain stimulation techniques to the prefrontal cortex may present a promising opportunity for durable interventions in adolescent depression...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28629225/cortical-plasticity-in-depression
#13
REVIEW
Mariagiovanna Cantone, Alessia Bramanti, Giuseppe Lanza, Manuela Pennisi, Placido Bramanti, Giovanni Pennisi, Rita Bella
Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression. Moreover, a degree of cognitive impairment is frequently observed throughout the clinical spectrum of mood disorders, and the relationship between depression and cognition is often bidirectional...
May 2017: ASN Neuro
https://www.readbyqxmd.com/read/28585931/the-modulation-of-adult-neuroplasticity-is-involved-in-the-mood-improving-actions-of-atypical-antipsychotics-in-an-animal-model-of-depression
#14
M Morais, P Patrício, A Mateus-Pinheiro, N D Alves, A R Machado-Santos, J S Correia, J Pereira, L Pinto, N Sousa, J M Bessa
Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, a large proportion of patients treated with currently available antidepressant drugs fail to achieve remission. Recently, antipsychotic drugs have received approval for the treatment of antidepressant-resistant forms of major depression. The modulation of adult neuroplasticity, namely hippocampal neurogenesis and neuronal remodeling, has been considered to have a key role in the therapeutic effects of antidepressants...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28581531/genetics-and-pharmacogenetics-of-mood-disorders
#15
REVIEW
Alessandro Serretti
Genetic research in Psychiatry is viewed by clinicians with both hope and curiosity sometimes mixed with disillusionment. Indeed, in the last 30 years many results have not been confirmed and clinical applications are still missing. However recent findings suggest that we are at the beginning of a new era. A set of variants within neuroplasticity and inflammation genes have been identified as a valid basis for both bipolar disorder and major depression. Similarly, a set of genes has been identified as a liability factor for response and tolerability to antidepressants and the first clinical applications are already in the market...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28529805/physical-activity-modulates-common-neuroplasticity-substrates-in-major-depressive-and-bipolar-disorder
#16
REVIEW
Cristy Phillips
Mood disorders (MDs) are chronic, recurrent mental diseases that affect millions of individuals worldwide. Although the biogenic amine model has provided some clinical utility, a need remains to better understand the interrelated mechanisms that contribute to neuroplasticity deficits in MDs and the means by which various therapeutics mitigate them. Of those therapeutics being investigated, physical activity (PA) has shown clear and consistent promise. Accordingly, the aims of this review are to (1) explicate key modulators, processes, and interactions that impinge upon multiple susceptibility points to effectuate neuroplasticity deficits in MDs; (2) explore the putative mechanisms by which PA mitigates these features; (3) review protocols used to induce the positive effects of PA in MDs; and (4) highlight implications for clinicians and researchers...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28507774/footnotes-to-kraepelin-changes-in-the-classification-of-mood-disorders-with-dsm-5
#17
EDITORIAL
Nicola J Kalk, Allan H Young
SUMMARY: Reliable diagnosis of mood disorders continues to pose a challenge. This is surprising because they have been recognised clinically since classical times. Mood disorders are also common: major depressive disorder affects nearly 300 million people worldwide and bipolar affective disorder nearly 60 million and they are a major cause of disability. Nonetheless, the reliability trials of the updated Diagnostic and Statistical Manual, Fifth Edition (DSM-5) found that the reliability of the diagnosis of major depressive disorder was in the 'questionable' range...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28490916/the-cannabis-withdrawal-syndrome-current-insights
#18
REVIEW
Udo Bonnet, Ulrich W Preuss
The cannabis withdrawal syndrome (CWS) is a criterion of cannabis use disorders (CUDs) ( Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition ) and cannabis dependence (International Classification of Diseases [ICD]-10). Several lines of evidence from animal and human studies indicate that cessation from long-term and regular cannabis use precipitates a specific withdrawal syndrome with mainly mood and behavioral symptoms of light to moderate intensity, which can usually be treated in an outpatient setting...
2017: Substance Abuse and Rehabilitation
https://www.readbyqxmd.com/read/28442348/upregulation-of-neurotrophins-by-s-47445-a-novel-positive-allosteric-modulator-of-ampa-receptors-in-aged-rats
#19
Francesca Calabrese, Elisa Savino, Elisabeth Mocaer, Sylvie Bretin, Giorgio Racagni, Marco A Riva
At molecular levels, it has been shown that aging is associated with alterations in neuroplastic mechanisms. In this study, it was examined if the altered expression of neurotrophins observed in aged rats could be corrected by a chronic treatment with S 47445 (1-3-10mg/kg, p.o.), a novel selective positive allosteric modulator of the AMPA receptors. Both the mRNA and the protein levels of the neurotrophins Bdnf, NT-3 and Ngf were specifically measured in the prefrontal cortex and hippocampus (ventral and dorsal) of aged rats...
July 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28373806/serum-brain-derived-neurotrophic-factor-levels-among-euthymic-adolescents-with-bipolar-disorder-type-i
#20
Nagihan Cevher Binici, Fatma Neslihan Inal Emiroğlu, Halil Resmi, Hülya Ellidokuz
INTRODUCTION: Bipolar disorder (BD) has been increasingly associated with abnormalities in neuroplasticity and cellular resilience in brain regions that are involved in mood and that affect regulation. Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family that regulates neuroplasticity. The aims of the current study were to compare serum BDNF levels in euthymic adolescents with BD type I with those in controls and to investigate the relationship between clinical variables and serum BDNF levels in adolescents with BD type I...
September 2016: Noro Psikiyatri Arsivi
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