Lindsay P Cameron, Joseph Benetatos, Vern Lewis, Emma M Bonniwell, Alaina M Jaster, Rafael Moliner, Eero Castrén, John D McCorvy, Mikael Palner, Argel Aguilar-Valles
Serotonergic psychedelics, such as psilocybin and LSD, have garnered significant attention in recent years for their potential therapeutic effects and unique mechanisms of action. These compounds exert their primary effects through activating serotonin 5-HT2A receptors, found predominantly in cortical regions. By interacting with these receptors, serotonergic psychedelics induce alterations in perception, cognition, and emotions, leading to the characteristic psychedelic experience. One of the most crucial aspects of serotonergic psychedelics is their ability to promote neuroplasticity, the formation of new neural connections, and rewire neuronal networks...
November 8, 2023: Journal of Neuroscience