Dusten Unruh, Ramprasad Srinivasan, Tyler Benson, Stephen Haigh, Danielle Coyle, Neil Batra, Ryan Keil, Robert Sturm, Victor Blanco, Mary Palascak, Robert S Franco, Wilson Tong, Tapan Chatterjee, David Y Hui, W Sean Davidson, Bruce J Aronow, Theodosia Kalfa, David Manka, Abigail Peairs, Andra Blomkalns, David J Fulton, Julia E Brittain, Neal L Weintraub, Vladimir Y Bogdanov
BACKGROUND: High-fat diet (HFD) promotes endothelial dysfunction and proinflammatory monocyte activation, which contribute to atherosclerosis in obesity. We investigated whether HFD also induces the dysfunction of red blood cells (RBCs), which serve as a reservoir for chemokines via binding to Duffy antigen receptor for chemokines (DARC). METHODS AND RESULTS: A 60% HFD for 12 weeks, which produced only minor changes in lipid profile in C57/BL6 mice, markedly augmented the levels of monocyte chemoattractant protein-1 bound to RBCs, which in turn stimulated macrophage migration through an endothelial monolayer...
November 17, 2015: Circulation