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Andra blomkalns

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https://www.readbyqxmd.com/read/26467254/red-blood-cell-dysfunction-induced-by-high-fat-diet-potential-implications-for-obesity-related-atherosclerosis
#1
Dusten Unruh, Ramprasad Srinivasan, Tyler Benson, Stephen Haigh, Danielle Coyle, Neil Batra, Ryan Keil, Robert Sturm, Victor Blanco, Mary Palascak, Robert S Franco, Wilson Tong, Tapan Chatterjee, David Y Hui, W Sean Davidson, Bruce J Aronow, Theodosia Kalfa, David Manka, Abigail Peairs, Andra Blomkalns, David J Fulton, Julia E Brittain, Neal L Weintraub, Vladimir Y Bogdanov
BACKGROUND: High-fat diet (HFD) promotes endothelial dysfunction and proinflammatory monocyte activation, which contribute to atherosclerosis in obesity. We investigated whether HFD also induces the dysfunction of red blood cells (RBCs), which serve as a reservoir for chemokines via binding to Duffy antigen receptor for chemokines (DARC). METHODS AND RESULTS: A 60% HFD for 12 weeks, which produced only minor changes in lipid profile in C57/BL6 mice, markedly augmented the levels of monocyte chemoattractant protein-1 bound to RBCs, which in turn stimulated macrophage migration through an endothelial monolayer...
November 17, 2015: Circulation
https://www.readbyqxmd.com/read/25490214/isolation-and-excision-of-murine-aorta-a-versatile-technique-in-the-study-of-cardiovascular-disease
#2
Nathan Robbins, Allie Thompson, Adrien Mann, Andra L Blomkalns
Cardiovascular disease is a broad term describing disease of the heart and/or blood vessels. The main blood vessel supplying the body with oxygenated blood is the aorta. The aorta may become affected in diseases such as atherosclerosis and aneurysm. Researchers investigating these diseases would benefit from direct observation of the aorta to characterize disease progression as well as to evaluate efficacy of potential therapeutics. The goal of this protocol is to describe proper isolation and excision of the aorta to aid investigators researching cardiovascular disease...
2014: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/25214978/five-year-mortality-and-coronary-heart-disease-development-after-normal-coronary-angiogram
#3
Jason T McMullan, Christopher J Lindsell, Andra L Blomkalns
BACKGROUND: Previous studies depict low cardiac event and mortality rates in patients with angiographically normal coronary arteries. These studies, however, are limited by small sample sizes, short follow-up intervals, and selection biases. This study was undertaken to determine the natural five-year course of a diverse cohort of subjects with documented normal coronary arteries with respect to coronary heart disease development, revascularization need, and all-cause mortality. METHODS: Consecutive adult patients with angiographically normal coronary arteries were followed up for 5 years through medical record review...
2011: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/24947528/transplanted-perivascular-adipose-tissue-accelerates-injury-induced-neointimal-hyperplasia-role-of-monocyte-chemoattractant-protein-1
#4
David Manka, Tapan K Chatterjee, Lynn L Stoll, Joshua E Basford, Eddy S Konaniah, Ramprasad Srinivasan, Vladimir Y Bogdanov, Yaoliang Tang, Andra L Blomkalns, David Y Hui, Neal L Weintraub
OBJECTIVE: Perivascular adipose tissue (PVAT) expands during obesity, is highly inflamed, and correlates with coronary plaque burden and increased cardiovascular risk. We tested the hypothesis that PVAT contributes to the vascular response to wire injury and investigated the underlying mechanisms. APPROACH AND RESULTS: We transplanted thoracic aortic PVAT from donor mice fed a high-fat diet to the carotid arteries of recipient high-fat diet-fed low-density lipoprotein receptor knockout mice...
August 2014: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/24101673/hdac9-knockout-mice-are-protected-from-adipose-tissue-dysfunction-and-systemic-metabolic-disease-during-high-fat-feeding
#5
Tapan K Chatterjee, Joshua E Basford, Ellen Knoll, Wilson S Tong, Victor Blanco, Andra L Blomkalns, Steven Rudich, Alex B Lentsch, David Y Hui, Neal L Weintraub
During chronic caloric excess, adipose tissue expands primarily by enlargement of individual adipocytes, which become stressed with lipid overloading, thereby contributing to obesity-related disease. Although adipose tissue contains numerous preadipocytes, differentiation into functionally competent adipocytes is insufficient to accommodate the chronic caloric excess and prevent adipocyte overloading. We report for the first time that a chronic high-fat diet (HFD) impairs adipogenic differentiation, leading to accumulation of inefficiently differentiated adipocytes with blunted expression of adipogenic differentiation-specific genes...
January 2014: Diabetes
https://www.readbyqxmd.com/read/23737535/human-coronary-artery-perivascular-adipocytes-overexpress-genes-responsible-for-regulating-vascular-morphology-inflammation-and-hemostasis
#6
Tapan K Chatterjee, Bruce J Aronow, Wilson S Tong, David Manka, Yaoliang Tang, Vladimir Y Bogdanov, Dusten Unruh, Andra L Blomkalns, Mark G Piegore, Daniel S Weintraub, Steven M Rudich, David G Kuhel, David Y Hui, Neal L Weintraub
Inflammatory cross talk between perivascular adipose tissue and the blood vessel wall has been proposed to contribute to the pathogenesis of atherosclerosis. We previously reported that human perivascular (PV) adipocytes exhibit a proinflammatory phenotype and less adipogenic differentiation than do subcutaneous (SQ) adipocytes. To gain a global view of the genomic basis of biologic differences between PV and SQ adipocytes, we performed genome-wide expression analyses to identify differentially expressed genes between adipocytes derived from human SQ vs...
August 15, 2013: Physiological Genomics
https://www.readbyqxmd.com/read/23537804/cd14-directs-adventitial-macrophage-precursor-recruitment-role-in-early-abdominal-aortic-aneurysm-formation
#7
Andra L Blomkalns, Daniel Gavrila, Manesh Thomas, Bonnie S Neltner, Victor M Blanco, Stephanie B Benjamin, Michael L McCormick, Lynn L Stoll, Gerene M Denning, Sean P Collins, Zhenyu Qin, Alan Daugherty, Lisa A Cassis, Robert W Thompson, Robert M Weiss, Paul D Lindower, Susan M Pinney, Tapan Chatterjee, Neal L Weintraub
BACKGROUND: Recruitment of macrophage precursors to the adventitia plays a key role in the pathogenesis of abdominal aortic aneurysms (AAAs), but molecular mechanisms remain undefined. The innate immune signaling molecule CD14 was reported to be upregulated in adventitial macrophages in a murine model of AAA and in monocytes cocultured with aortic adventitial fibroblasts (AoAf) in vitro, concurrent with increased interleukin-6 (IL-6) expression. We hypothesized that CD14 plays a crucial role in adventitial macrophage precursor recruitment early during AAA formation...
April 2013: Journal of the American Heart Association
https://www.readbyqxmd.com/read/21680747/histone-deacetylase-9-is-a-negative-regulator-of-adipogenic-differentiation
#8
Tapan K Chatterjee, Gila Idelman, Victor Blanco, Andra L Blomkalns, Mark G Piegore, Daniel S Weintraub, Santosh Kumar, Srinivas Rajsheker, David Manka, Steven M Rudich, Yaoliang Tang, David Y Hui, Rhonda Bassel-Duby, Eric N Olson, Jerry B Lingrel, Shuk-Mei Ho, Neal L Weintraub
Differentiation of preadipocytes into mature adipocytes capable of efficiently storing lipids is an important regulatory mechanism in obesity. Here, we examined the involvement of histone deacetylases (HDACs) and histone acetyltransferases (HATs) in the regulation of adipogenesis. We find that among the various members of the HDAC and HAT families, only HDAC9 exhibited dramatic down-regulation preceding adipogenic differentiation. Preadipocytes from HDAC9 gene knock-out mice exhibited accelerated adipogenic differentiation, whereas HDAC9 overexpression in 3T3-L1 preadipocytes suppressed adipogenic differentiation, demonstrating its direct role as a negative regulator of adipogenesis...
August 5, 2011: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/21352551/low-level-bacterial-endotoxin-activates-two-distinct-signaling-pathways-in-human-peripheral-blood-mononuclear-cells
#9
Andra L Blomkalns, Lynn L Stoll, Wassim Shaheen, Sara A Romig-Martin, Eric W Dickson, Neal L Weintraub, Gerene M Denning
BACKGROUND: Bacterial endotoxin, long recognized as a potent pro-inflammatory mediator in acute infectious processes, has more recently been identified as a risk factor for atherosclerosis and other cardiovascular diseases. When endotoxin enters the bloodstream, one of the first cells activated is the circulating monocyte, which exhibits a wide range of pro-inflammatory responses. METHODS: We studied the effect of low doses of E. coli LPS on IL-8 release and superoxide formation by freshly isolated human peripheral blood mononuclear cells (PBMC)...
2011: Journal of Inflammation
https://www.readbyqxmd.com/read/20952100/the-time-dependence-of-antithrombin-initiation-in-patients-with-non-st-segment-elevation-acute-coronary-syndromes-subgroup-analysis-from-the-acuity-trial
#10
MULTICENTER STUDY
Deborah B Diercks, Charles V Pollack, Judd E Hollander, Andra L Blomkalns, Charles L Emerman, Ivan C Rokos, David M Larson, James W Hoekstra, Roxana Mehran, Gregg W Stone
STUDY OBJECTIVE: Antithrombins are among standard treatment agents for patients with non-ST-segment elevation acute coronary syndromes. We aimed to determine the association between time from emergency department (ED) presentation to treatment with an antithrombin and adverse cardiac events. METHODS: The study cohort was a subgroup of the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial, enrolled from March 1, 2005, to December 5, 2005...
March 2011: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/20823958/the-association-between-money-and-opinion-in-academic-emergency-medicine
#11
Robert H Birkhahn, Andra Blomkalns, Howard Klausner, Richard Nowak, Ali S Raja, Richard Summers, Jim E Weber, William M Briggs, Alp Arkun, Deborah Diercks
OBJECTIVES: Financial conflicts of interest have come under increasing scrutiny in medicine, but their impact has not been quantified. Our objective was to use the results of a national survey of academic emergency medicine (EM) faculty to determine if an association between money and personal opinion exists. METHODS: We conducted a web-based survey of EM faculty. Opinion questions were analyzed with regard to whether the respondent had either 1) received research grant money or 2) received money from industry as a speaker, consultant, or advisor...
May 2010: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/20598976/gender-differences-in-time-to-presentation-for-myocardial-infarction-before-and-after-a-national-women-s-cardiovascular-awareness-campaign-a-temporal-analysis-from-the-can-rapid-risk-stratification-of-unstable-angina-patients-suppress-adverse-outcomes-with
#12
RANDOMIZED CONTROLLED TRIAL
Deborah B Diercks, Kelly P Owen, Michael C Kontos, Andra Blomkalns, Anita Y Chen, Chadwick Miller, Stephen Wiviott, Eric D Peterson
BACKGROUND: In 2001-2002, the American Heart Association and National Heart, Lung, and Blood Institute initiated national campaigns with the aim of increasing women's awareness of their risk of heart disease, with particular focus on women aged 40 to 60 years. Our aim is to determine if these women's awareness campaigns were associated with a reduction in the time to hospital presentation for myocardial infarction in women. METHODS: The study population comprised patients who presented with a non-ST-segment elevation myocardial infarction in the Can Rapid Risk Stratification of Unstable Angina Patients Suppress ADverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines Registry and the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network-Get with the Guidelines registry...
July 2010: American Heart Journal
https://www.readbyqxmd.com/read/20097767/turning-acs-outside-in-linking-perivascular-adipose-tissue-to-acute-coronary-syndromes
#13
EDITORIAL
Andra L Blomkalns, Tapan Chatterjee, Neal L Weintraub
No abstract text is available yet for this article.
March 2010: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/20060362/crosstalk-between-perivascular-adipose-tissue-and-blood-vessels
#14
REVIEW
Srinivas Rajsheker, David Manka, Andra L Blomkalns, Tapan K Chatterjee, Lynn L Stoll, Neal L Weintraub
Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined...
April 2010: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/19743496/the-usage-patterns-of-cardiac-bedside-markers-employing-point-of-care-testing-for-troponin-in-non-st-segment-elevation-acute-coronary-syndrome-results-from-crusade
#15
MULTICENTER STUDY
Kevin M Takakuwa, Fang-Shu Ou, Eric D Peterson, Charles V Pollack, W Frank Peacock, James W Hoekstra, E Magnus Ohman, W Brian Gibler, Andra L Blomkalns, Matthew T Roe
BACKGROUND: Point-of-care (POC) testing may expedite the care of emergency department (ED) patients suspected of having acute coronary syndromes (ACS). We evaluated the use patterns of cardiac bedside markers or POC testing for troponin in patients with non-ST-segment elevation (NSTE) ACS. METHODS: NSTE ACS data were collected from the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association (ACC/AHA) Guidelines (CRUSADE) registry...
September 2009: Clinical Cardiology
https://www.readbyqxmd.com/read/19673711/safety-and-efficacy-of-bivalirudin-in-high-risk-patients-admitted-through-the-emergency-department
#16
RANDOMIZED CONTROLLED TRIAL
Chadwick D Miller, Andra L Blomkalns, Bernard J Gersh, Charles V Pollack, Gerard X Brogan, Deborah B Diercks, W Frank Peacock, Gregg W Stone, Judd E Hollander, Steven V Manoukian, James W Hoekstra et al.
OBJECTIVES: The objective was to assess the safety and efficacy of bivalirudin monotherapy in patients with high-risk acute coronary syndrome (ACS) presenting to the emergency department (ED). METHODS: Data from the Acute Catheterization and Urgent Intervention Triage StrategY (ACUITY) trial were used to conduct a post hoc subgroup analysis of high-risk ACS patients (cardiac biomarker elevation or ST-segment deviation) who initially presented to the ED. The ACUITY trial randomized patients to receive heparin (unfractionated [UFH] or enoxaparin) plus glycoprotein IIb/IIIa inhibition (GPI), bivalirudin plus GPI, or bivalirudin monotherapy...
August 2009: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/19396642/society-of-chest-pain-centers-recommendations-for-the-evaluation-and-management-of-the-observation-stay-acute-heart-failure-patient-parts-1-6
#17
REVIEW
W Frank Peacock, Gregg C Fonarow, Douglas S Ander, Sean P Collins, Mihai Gheorghiade, J Douglas Kirk, Gerasimos Filippatos, Deborah B Diercks, Robin J Trupp, Brian Hiestand, Ezra A Amsterdam, William T Abraham, Ezra A Amsterdam, Gail Dodge, David F Gaieski, Diane Gurney, Christy O Hayes, Judd E Hollander, Kay Holmes, James L Januzzi, Phillip Levy, Alan Maisel, Chadwick D Miller, Peter S Pang, Elsie Selby, Alan B Storrow, Neal L Weintraub, Clyde W Yancy, Raymond D Bahr, Andra L Blomkalns, James McCord, Richard M Nowak, Robert J Stomel
No abstract text is available yet for this article.
2009: Acute Cardiac Care
https://www.readbyqxmd.com/read/19244632/academic-emergency-medicine-faculty-and-industry-relationships
#18
Robert H Birkhahn, Andra L Blomkalns, Howard A Klausner, Richard M Nowak, Ali S Raja, Richard L Summers, Jim E Weber, William M Briggs, Alp Arkun, Deborah Diercks
OBJECTIVES: The authors surveyed the membership of the Society for Academic Emergency Medicine (SAEM) about their associations with industry and predictors of those associations. METHODS: A national Web-based survey inviting faculty from the active member list of SAEM was conducted. Follow-up requests for participation were sent weekly for 3 weeks. Information was collected on respondents' personal and practice characteristics, industry interactions, and personal opinions regarding these interactions...
September 2008: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/19122178/proinflammatory-phenotype-of-perivascular-adipocytes-influence-of-high-fat-feeding
#19
COMPARATIVE STUDY
Tapan K Chatterjee, Lynn L Stoll, Gerene M Denning, Allan Harrelson, Andra L Blomkalns, Gila Idelman, Florence G Rothenberg, Bonnie Neltner, Sara A Romig-Martin, Eric W Dickson, Steven Rudich, Neal L Weintraub
Adipose tissue depots originate from distinct precursor cells, are functionally diverse, and modulate disease processes in a depot-specific manner. However, the functional properties of perivascular adipocytes, and their influence on disease of the blood vessel wall, remain to be determined. We show that human coronary perivascular adipocytes exhibit a reduced state of adipocytic differentiation as compared with adipocytes derived from subcutaneous and visceral (perirenal) adipose depots. Secretion of antiinflammatory adiponectin is markedly reduced, whereas that of proinflammatory cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1, is markedly increased in perivascular adipocytes...
February 27, 2009: Circulation Research
https://www.readbyqxmd.com/read/17967956/guideline-implementation-research-exploring-the-gap-between-evidence-and-practice-in-the-crusade-quality-improvement-initiative
#20
Andra L Blomkalns, Matthew T Roe, Eric D Peterson, E Magnus Ohman, Elizabeth S Fraulo, W Brian Gibler
Translating research results into routine clinical practice remains difficult. Guidelines, such as the 2002 American College of Cardiology/American Heart Association Guidelines for the Management of Patients with Unstable Angina and non-ST-segment elevation myocardial infarction, have been developed to provide a streamlined, evidence-based approach to patient care that is of high quality and is reproducible. The Can Rapid Risk Stratification of Unstable Angina Patients Suppress ADverse Outcomes with Early Implementation (CRUSADE) Quality Improvement Initiative was developed as a registry for non-ST-segment elevation acute coronary syndromes to track the use of guideline-based acute and discharge treatments for hospitalized patients, as well as outcomes associated with the use of these treatments...
November 2007: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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