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chronic obstructive pulmonary

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https://www.readbyqxmd.com/read/29684057/serum-galactomannan-antigen-as-a-prognostic-and-diagnostic-marker-for-invasive-aspergillosis-in-heterogeneous-medicine-icu-patient-population
#1
Yubhisha Dabas, Anant Mohan, Immaculata Xess
OBJECTIVE: This study was conducted to get a complete clinical and mycological picture of invasive aspergillosis (IA) in respiratory medicine ICU of a tertiary care hospital. PATIENTS: From the cohort of 235 patients only one had proven IA. Based on AspICU algorithm, 21 had putative IA (8.9%), 12 were colonised (5.1%). RESULTS: Adjusting the confounding factors, significant risk factors for IA were chronic obstructive pulmonary disease (COPD), temperature of ≥38°C, pneumonia and acute respiratory distress syndrome (ARDS)...
2018: PloS One
https://www.readbyqxmd.com/read/29683730/biologic-drugs-a-new-target-therapy-in-copd
#2
Ahmed Yousuf, Christopher E Brightling
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease associated with significant morbidity and mortality. Current diagnostic criteria based on the presence of fixed airflow obstruction and symptoms do not integrate the complex pathological changes occurring within the lung and they do not define different airway inflammatory patterns. The current management of COPD is based on 'one size fits all' approach and does not take the importance of heterogeneity in COPD population into account. The available treatments aim to alleviate symptoms and reduce exacerbation frequency but do not alter the course of the disease...
April 23, 2018: COPD
https://www.readbyqxmd.com/read/29683370/nutritional-supplement-bao-khi-khang-as-an-adjuvant-therapy-in-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#3
Ba X Hoang, Bo Han, Hoang X Nguyen, Khanh T Dang
To investigate the effectiveness of nutritional supplement Bao Khi Khang as an adjuvant therapy in acute exacerbations of chronic obstructive pulmonary disease (COPD) compared to conventional therapy alone. This was a prospective, randomized, open-label controlled trial in 60 patients presenting with acute exacerbation of COPD. Patients were randomized into two groups, the control and the experimental groups. The control group was treated with the standard therapeutic protocol (Antimicrobial+Corticosteroids+Bronchodilator+Mucolytic drugs)...
April 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29681728/harmful-impact-of-air-pollution-on-severe-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-particulate-matter-is-hazardous
#4
Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Kyung Ho Kang, Jae Jeong Shim
Introduction: Particulate matter and air pollution in Korea are becoming worse. There is a lack of research regarding the impact of particulate matter on patients with COPD. Therefore, the purpose of this study was to investigate the effects of various air pollution factors, including particulate matter, on the incidence rate of severe acute exacerbations of COPD (AECOPD) events. Methods: We analyzed the relationship between air pollutants and AECOPD events that required hospitalization at Guro Hospital in Korea from January 1, 2015 to May 31, 2017...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29680890/the-relationship-between-diurnal-temperature-range-and-copd-hospital-admissions-in-changchun-china
#5
Yuxia Ma, Yuxin Zhao, Jianding Zhou, Yunyan Jiang, Sixu Yang, Zhiang Yu
Diurnal temperature range (DTR) has been suggested to be an adverse health factor especially related to respiratory and cardiovascular diseases. In the current study, we investigated the association between DTR and chronic obstructive pulmonary disease (COPD) hospital admissions during 2009 to 2012 in northeast city of Changchun, China. Based on generalized additive model (GAM), the effects were expressed as relative risk (RR) values of COPD with 95% confidence intervals (CIs) with each 1 °C increase in DTR...
April 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29680737/reduced-expression-of-growth-differentiation-factor-11-promoted-the-progression-of-chronic-obstructive-pulmonary-disease-by-activating-the-akt-signaling-pathway
#6
Feng Tang, Chunhua Ling, Jinming Liu
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease, which is associated with significant mortality and costs. The molecular mechanisms underlying the roles of cigarette smoke (an accepted risk factor for COPD) and growth differentiation factor 11 (GDF11), which is reduced in patients with COPD, in the occurrence of COPD are unclear. The aim of the present study was to explore the function of GDF11 in the progression of COPD. Western blotting analysis was used to determine the expression levels of GDF11 in serum and primary lung mesenchymal cells from patients with COPD and the healthy people, and the effect of cigarette smoke extract (CSE) on the expression of AKT, p-AKT (Ser473), p-AKT (Thr308) and GDF11 was examined...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29680578/the-effects-of-psychological-distress-and-its-interaction-with-socioeconomic-position-on-risk-of-developing-four-chronic-diseases
#7
Kyle J J McLachlan, Catharine R Gale
OBJECTIVE: To examine the relationship between psychological distress and risk of developing arthritis, cardiovascular disease, chronic obstructive pulmonary disease and diabetes across the range of distress severity, investigate the mediating roles of health behaviours and explore whether the associations vary with socioeconomic position. METHODS: Participants were 16,485 adults from the UK Household Longitudinal Study We examined prospective relationships between psychological distress at baseline (measured using the 12-item General Health Questionnaire) and incidence of arthritis, cardiovascular disease, chronic obstructive pulmonary disease and diabetes (measured using self-report) over 3 years using logistic regression...
April 14, 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29679596/observational-studies-of-inhaled-corticosteroid-effectiveness-in-copd-lessons-learned
#8
Samy Suissa, Pierre Ernst
BACKGROUND: Randomized controlled trials at times investigate findings suggested by observational studies. For example, the TORCH trial, which did not show a mortality reduction with inhaled corticosteroids (ICS) in chronic obstructive pulmonary disease (COPD), was motivated by some observational studies that suggested considerable reductions in mortality with these drugs. Reasons for these discrepancies are unclear. METHODS: We searched the literature to identify all observational studies, including cohort and case-control studies, investigating the effectiveness of ICS on major outcomes in COPD patients, including death and hospitalization for COPD...
April 18, 2018: Chest
https://www.readbyqxmd.com/read/29679366/blood-group-and-incidence-of-asthma-and-chronic-obstructive-pulmonary-disease
#9
Bożena Mroczek, Zygmunt Sitko, Agnieszka Sujewicz, Weronika Wolińska, Iwona Karpeta-Pawlak, Donata Kurpas
Chronic respiratory diseases are determined by genetic predisposition, and environmental and socioeconomic variables. One genetic factor underlying susceptibility to such diseases can be the ABO blood group system. The purpose of this study was to investigate the hypothesis that there would be a relationship between the blood group and risk of developing asthma and chronic obstructive pulmonary disease (COPD). We reviewed medical history files of patients with the diagnosis of COPD or asthma, including those suffering from a cancerous disease accompanied by asthma or COPD, hospitalized from January 2016 to July 2017...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679365/influence-of-gaseous-pollutants-on-copd-exacerbations-in-patients-with-cardiovascular-comorbidities
#10
Michal Zielinski, Mariusz Gasior, Dariusz Jastrzebski, Aneta Desperak, Dariusz Ziora
Exacerbations of chronic obstructive pulmonary disease (COPD) are a serious public health issue. Ambient pollution and meteorological factors are considered among precipitating factors. There are few data concerning the impact of ambient pollutants other than particulates on COPD exacerbations. Among gaseous pollutants four main groups of substances are primarily monitored: nitrogen oxides (NOx), sulphur dioxide (SO2 ), carbon monoxide (CO), and ozone (O3 ). In this study, 12,889 hospitalizations in the years 2006-2014 due to exacerbations of COPD in patients having a co-existing cardiovascular pathology were retrospectively analyzed...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679364/estimates-of-medication-expenditure-for-ischemic-heart-disease-accompanying-chronic-obstructive-pulmonary-disease
#11
Edyta Rysiak, Izabela Prokop, Ilona Zaręba, Robert M Mróz
Ischemic heart disease (IHD) is a frequent accompaniment of chronic obstructive pulmonary disease (COPD). Co-occurrence of these two diseases is associated with many risk factors, difficulties in implementing appropriate therapies, numerous complications, and high spending for treatment. All these elements significantly reduce the quality of life of patients. The aim of this study was to estimate the expenditure for medications involved with IHD pharmacotherapy in the course of COPD. This retrospective study was based on the review of medical files of 57 patients, 27 women and 30 men, diagnosed with IHD, according to the severity classification, in the course of COPD which was staged according to the GOLD criteria...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29678648/determinants-of-health-related-quality-of-life-1-year-after-pulmonary-thromboendarterectomy
#12
Oksana Kamenskaya, Asya Klinkova, Irina Loginova, Alexander Chernyavskiy, Alexander Edemskiy, Vladimir V Lomivorotov, Alexander Karaskov
AIM: Pulmonary thromboendarterectomy (PTE) is a recognized treatment for patients with chronic thromboembolic pulmonary hypertension (CTEPH), with good long-term haemodynamic results. The aim of this study was to test the hypothesis that the dynamics of health-related quality of life (QoL), 1 year after PTE, depends both on the clinical determinants associated with the underlying disease and the adverse events occurring in the early postoperative period. METHODS: This prospective cohort study included 136 patients with CTEPH...
April 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678351/clinical-and-inflammatory-phenotyping-can-electronic-nose-and-nmr-based-metabolomics-work-at-the-bedside
#13
Mauro Maniscalco, Andrea Motta
Electronic nose (eNose) and nuclear magnetic resonance (NMR)-based metabolomics seem to be able to identify metabolic and inflammatory profiles in patients with chronic obstructive diseases. The hypothesis arises from three recent studies using two different methods in patients with asthma and chronic obstructive pulmonary diseases (COPD), opening promising diagnostic perspectives. The possibility that the use of eNose and NMR-based metabolomics might provide clinical/inflammatory characteristics is intriguing...
April 17, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29678160/the-increasing-burden-and-complexity-of-multi-morbidity-and-polypharmacy-in-geriatric-hiv-patients-a-cross-sectional-study-of-people-aged-65-74-years-and-more-than-75-years
#14
G Guaraldi, A Malagoli, A Calcagno, C Mussi, B M Celesia, F Carli, S Piconi, G V De Socio, A M Cattelan, G Orofino, A Riva, E Focà, S Nozza, G Di Perri
BACKGROUND: Geriatric Patients Living with HIV/AIDS (GEPPO) is a new prospective observational multicentre cohort consisting of all the HIV-positive geriatric patients being treated at 10 clinics in Italy, and HIV-negative controls attending a single geriatric clinic. The aim of this analysis of the GEPPO cohort was to compare prevalence and risk factors of individual non-communicable diseases (NCD), multi-morbidity (MM) and polypharmacy (PP) amongst HIV positive and HIV negative controls at enrolment into the GEPPO cohort...
April 20, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29676646/ambient-air-pollution-and-clinical-implications-for-susceptible-populations
#15
Laura G Hooper, Joel D Kaufman
Air pollution is associated with a diversity of health effects, and evidence for a causal relationship with specific diseases exists. Exposure to air pollution is ubiquitous and typically beyond the control of the individual; the resulting health burden for the population can be high. Disproportionate effects are seen in individuals who have increased susceptibility to air pollution owing to individual- or community-level characteristics. As studies grow increasingly sophisticated, the understanding of who comprises the susceptible population continuously expands...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676635/effects-of-household-air-pollution-in-malawi-and-human-immunodeficiency-virus-status-on-respiratory-symptoms-and-inflammation-injury-and-repair-markers
#16
Charles Kim, Hannah Jary, Kevin Mortimer, Kelly S Schweitzer, Doug Curran-Everett, Stephen Gordon, Irina Petrache
RATIONALE: Household air pollution (HAP) and human immunodeficiency virus (HIV) are associated with increased risk for chronic obstructive pulmonary disease. Both HAP and HIV are widespread in Sub-Saharan Africa, including Malawi, where HIV has 10.6% prevalence in patients 15-49 years old. OBJECTIVES: We hypothesized that HIV infection (HIV+ ) and habitual exposure to HAP (HAP+ ) synergize to cause systemic inflammation and vascular injury, which may herald early onset of chronic respiratory diseases...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676630/international-approach-to-environmental-and-lung-health-a-perspective-from-the-fogarty-international-center
#17
Roger I Glass, Joshua P Rosenthal
The global burden of lung disease is substantial, accounting for an estimated 7.5 million deaths per year, approximately 14% of annual deaths worldwide. The prime illnesses include, in descending order, chronic obstructive pulmonary disease, lung cancer, tuberculosis, acute respiratory infections, asthma, and interstitial lung fibrosis. Key risk factors include smoking, both indoor and outdoor air pollution, and occupational exposures. Although the distribution of both the diseases and the risk factors varies greatly by age, geography, and setting, the greatest burden falls on populations living in low- and middle-income countries...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676628/increasing-the-resolution-of-chronic-obstructive-pulmonary-disease-definition-lessons-from-a-cohort-with-remote-but-extensive-exposure-to-secondhand-tobacco-smoke
#18
Mehrdad Arjomandi, Siyang Zeng, Paul D Blanc, Warren M Gold
RATIONALE: The Global Initiative for Chronic Obstructive Lung Disease criteria require a ratio of forced expiratory volume in 1 second (FEV1 ) to forced vital capacity (FVC) (FEV1 /FVC) of less than 0.70 for the diagnosis of chronic obstructive pulmonary disease, whereas other criteria emphasize a lower limit of normal approach. However, the use of Global Initiative for Chronic Obstructive Lung Disease (or lower limit of normal) criteria may result in classification of many smokers with respiratory morbidities as not having chronic obstructive pulmonary disease...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676627/effect-of-world-trade-center-dust-exposure-and-chronic-intermittent-hypoxia-on-macrophage-matrix-metalloproteinase-12-expression-in-mice
#19
Jared Radbel, Oanh Le-Hoang, Kinal N Vayas, Kaiwal Patel, Michael Goedken, Vasanthi R Sunil, Debra Laskin, Jag Sunderram
RATIONALE: The pathophysiologic mechanisms by which World Trade Center (WTC) dust exposure leads to pulmonary disease have not been established. Matrix metalloproteinase-12 (MMP-12) is involved in the development of pulmonary fibrosis and chronic obstructive pulmonary disease. We have previously shown that exposure of mice to WTC dust results in increased expression of matrix metalloproteinase 12 by alveolar macrophages. Matrix metalloproteinase 12 expression is regulated, in part, by oxidative stress, which is also increased after WTC dust exposure...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676626/chronic-obstructive-pulmonary-disease-and-herbicide-exposure-in-vietnam-era-u-s-army-chemical-corps-veterans
#20
Yasmin Cypel, Stella E Hines, Victoria J Davey, Stephanie M Eber, Aaron I Schneiderman
RATIONALE: Past research demonstrates a possible association between herbicide exposure and respiratory health. Biologic plausibility and inhalation as a mode of exposure further support the contention that herbicides may act as adverse contributors to respiratory status, especially in military personnel who were responsible for chemical maintenance and distribution during the Vietnam War. OBJECTIVES: This study examines the association between chronic obstructive pulmonary disease and herbicide exposure among Vietnam-era U...
April 2018: Annals of the American Thoracic Society
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