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https://www.readbyqxmd.com/read/29051069/procyanidins-from-cinnamomi-cortex-promote-proteasome-independent-degradation-of-nuclear-nrf2-through-phosphorylation-of-insulin-like-growth-factor-1-receptor-in-a549%C3%A2-cells
#1
Tomokazu Ohnuma, Kazuya Sakamoto, Asumi Shinoda, Chiaki Takagi, Shoko Ohno, Takahito Nishiyama, Kenichiro Ogura, Akira Hiratsuka
Many lines of evidence demonstrate that transcription factor nuclear factor-E2-related factor 2 (Nrf2) plays essential roles in cancer cell proliferation and resistance to chemotherapy, thereby indicating that suppression of abnormal Nrf2 activation is needed for a new therapeutic approach. Our previous studies reported that procyanidins prepared from Cinnamomi Cortex extract (CCE) have an ability to suppress cytoprotective enzymes and cell proliferation in human cancer cells with activated Nrf2. In the present study, we investigated the mechanism of CCE procyanidin-mediated antagonization of Nrf2...
October 16, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29050613/improvement-of-alkali-efficiency-for-purification-of-dissolving-pulp-by-a-modified-cold-caustic-extraction-process
#2
Liang He, Qing-Qing Guan, Lin-Cai Peng, Ke-Li Chen, Xin-Sheng Chai
In this study, a reutilization of caustic lye during cold caustic extraction (i.e., CCE) process to produce high-purity dissolving pulp and high-concentrated hemicellulose solution was proposed. The results showed that the lye can be reused about 12 times for producing high-purity dissolving pulps. With the number of CCE stages of 12, the hemicellulose in the lye can be auto-concentrated to about 37g/L. The alkali efficiency of the modified CCE process was about 6 (or 3) times better than the traditional CCE process with low- (or middle-) consistency of pulps...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29042625/radiation-resistance-of-silicon-carbide-schottky-diode-detectors-in-d-t-fusion-neutron-detection
#3
Linyue Liu, Ao Liu, Song Bai, Ling Lv, Peng Jin, Xiaoping Ouyang
Silicon carbide (SiC) is a wide band-gap semiconductor material with many excellent properties, showing great potential in fusion neutron detection. The radiation resistance of 4H-SiC Schottky diode detectors was studied experimentally by carefully analyzing the detectors' properties before and after deuterium-tritium fusion neutron irradiation with the total fluence of 1.31 × 10(14) n/cm(2) and 7.29 × 10(14) n/cm(2) at room temperature. Significant degradation has been observed after neutron irradiation: reverse current increased greatly, over three to thirty fold; Schottky junction was broken down; significant lattice damage was observed at low temperature photoluminescence measurements; the peaks of alpha particle response spectra shifted to lower channels and became wider; the charge collection efficiency (CCE) decreased by about 7...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28959734/drug-free-approach-to-study-the-unusual-cell-cycle-of-giardia-intestinalis
#4
Kathleen Horlock-Roberts, Chase Reaume, Guillem Dayer, Christine Ouellet, Nicholas Cook, Janet Yee
Giardia intestinalis is a protozoan parasite that causes giardiasis, a form of severe and infectious diarrhea. Despite the importance of the cell cycle in the control of proliferation and differentiation during a giardia infection, it has been difficult to study this process due to the absence of a synchronization procedure that would not induce cellular damage resulting in artifacts. We utilized counterflow centrifugal elutriation (CCE), a size-based separation technique, to successfully obtain fractions of giardia cultures enriched in G1, S, and G2...
September 2017: MSphere
https://www.readbyqxmd.com/read/28943551/cholesterol-crystal-embolism-induced-by-direct-factor-xa-inhibitor-a-first-case-report
#5
Hideaki Oka, Taro Kamimura, Yuki Hiramatsu, Kento Fukumitsu, Rei Iwata, Mika Kondo, Yutaro Hirashima, Seishi Aihara, Atsumi Harada, Kazuhiko Tsuruya
An 80-year-old man presented at our hospital with renal failure. He had been treated with edoxaban, an oral direct factor Xa inhibitor, for deep vein thrombosis for 10 months prior to admission. Although the pulses in his bilateral pedal arteries were palpable, cyanosis was present in the bilateral toes. Laboratory data indicated azotemia and eosinophilia. A skin biopsy confirmed a diagnosis of cholesterol crystal embolism (CCE). Because no invasive vascular procedure was performed, we assumed that CCE was related to edoxaban...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28928404/granule-cells-control-recovery-from-classical-conditioned-fear-responses-in-the-zebrafish-cerebellum
#6
Koji Matsuda, Masayuki Yoshida, Koichi Kawakami, Masahiko Hibi, Takashi Shimizu
Although previous studies show that the cerebellum is involved in classical fear conditioning, it is not clear which components in the cerebellum control it or how. We addressed this issue using a delayed fear-conditioning paradigm with late-stage zebrafish larvae, with the light extinguishment as the conditioned stimulus (CS) and an electric shock as the unconditioned stimulus (US). The US induced bradycardia in the restrained larvae. After paired-associate conditioning with the CS and US, a substantial population of the larvae displayed CS-evoked bradycardia responses...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901416/protective-role-of-berberine-and-coptischinensis-extract-on-t2md-rats-and-associated-islet-rin%C3%A2-5f-cells
#7
Yu-Yu Jiang, Han-Ming Cui, Jia-Long Wang, Hui Liu, Meng-Meng Dang, Qiu-Yan Zhang, Fang Yang, Jian-Tao Kou, Xiao-Lin Tong
The aim of the present study was to compare the different effects of berberine (Ber) and Coptischinensis extract (CCE) on a rat model of type 2 diabetes mellitus (T2DM), and the islet Rin‑5f cell line was used to examine the differences between Ber and CCE and the underlying mechanisms. CCE was extracted and purified prior to analysis. Male Sprague‑Dawley rats were provided with a high‑fat diet to induce insulin resistance prior to injecting with streptozotocinto establish the T2DM model, the T2DM rats were treated with Ber and CCE, and blood samples and pancreatic tissues were obtained and compared to examine T2DM metabolic syndromes among the groups of rats, which included healthy rats, model rats, and model rats treated with Ber and CCE at different doses between 0 and 8 weeks...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28887037/cholecalciterol-cholesterol-emulsion-attenuates-experimental-autoimmune-myocarditis-in-mice-via-inhibition-of-the-pyroptosis-signaling-pathway
#8
Ning Liu, Han Su, Yalin Zhang, Zuwang Liu, Juan Kong
1,25-dihydroxyvitamin D3 and its analog (paricalcitol) have beneficial effects on multiple systems and diseases, including myocarditis. However, the therapeutic effect of cholecalciterol cholesterol emulsion (CCE) on myocarditis and the role of pyroptosis in the progress of myocarditis have not been determined. The objective of this study was to investigate the effect of CCE on experimental autoimmune myocarditis and its underlying mechanisms. The ratio of heart weight to body weight was decreased after CCE treatment compared with vehicle-treated controls...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28872313/an-electrochemical-method-for-carboxylic-ester-synthesis-from-n-alkoxyamides
#9
Kripa Subramanian, Subhash L Yedage, Bhalchandra M Bhanage
An electrochemical method for the synthesis of carboxylic as well as hindered esters from N-alkoxyamides has been reported. The electrochemical reaction proceeds through constant current electrolysis (CCE) by taking advantage of the dual role of n-Bu4NI (TBAI) as the redox catalyst as well as the supporting electrolyte. Besides providing mild reaction conditions, the present protocol is free from external oxidants and conducting salts, thereby generating nitrogen as the nonhazardous side product. Additionally, the developed procedure is highly advantageous due to its short reaction time, wide substrate scope, and gram-scale synthesis...
September 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28866112/hemodynamic-assessment-of-patients-with-septic-shock-using-transpulmonary-thermodilution-and-critical-care-echocardiography-a-comparative-study
#10
Philippe Vignon, Emmanuelle Begot, Arnaud Mari, Stein Silva, Loïc Chimot, Pierre Delour, Frédéric Vargas, Bruno Filloux, David Vandroux, Julien Jabot, Bruno François, Nicolas Pichon, Marc Clavel, Bruno Levy, Michel Slama, Béatrice Riu-Poulenc
BACKGROUND: To assess the agreement between transpulmonary thermodilution (TPT) and critical care echocardiography (CCE) in ventilated patients with septic shock. METHODS: Ventilated patients in sinus rhythm requiring advanced hemodynamic assessment for septic shock were included in this prospective multicenter descriptive study. Patients were assessed successively using TPT and CCE in random order. Data were interpreted independently at bedside by two investigators who proposed therapeutic changes on the basis of predefined algorithms...
September 1, 2017: Chest
https://www.readbyqxmd.com/read/28808190/cholesterol-crystal-embolization-following-plaque-rupture-a-systemic-disease-with-unusual-features
#11
Firas Ghanem, Deepthi Vodnala, Jagadeesh K Kalavakunta, Sridevi Durga, Noah Thormeier, Prem Subramaniyam, Scott Abela, George S Abela
Cholesterol crystal embolic (CCE) syndrome is often a clinically challenging condition that has a poor prognostic implication. It is a result of plaque rupture with release of cholesterol crystals into the circulation that embolize into various tissue organs. Plaque rupture seems to be triggered by an expanding necrotic core during cholesterol crystallization forming sharp tipped crystals that perforate and tear the fibrous cap. Embolizing cholesterol crystals then initiate both local and systemic inflammation that eventually lead to vascular fibrosis and obstruction causing symptoms that can mimic other vasculitic conditions...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28755688/differential-physiological-effects-of-neonicotinoid-insecticides-on-honey-bees-a-comparison-between-apis-mellifera-and-apis-cerana
#12
Zhiguo Li, Meng Li, Jingfang He, Xiaomeng Zhao, Veeranan Chaimanee, Wei-Fone Huang, Hongyi Nie, Yazhou Zhao, Songkun Su
Acute toxicities (LD50s) of imidacloprid and clothianidin to Apis mellifera and A. cerana were investigated. Changing patterns of immune-related gene expressions and the activities of four enzymes between the two bee species were compared and analyzed after exposure to sublethal doses of insecticides. Results indicated that A. cerana was more sensitive to imidacloprid and clothianidin than A. mellifera. The acute oral LD50 values of imidacloprid and clothianidin for A. mellifera were 8.6 and 2.0ng/bee, respectively, whereas the corresponding values for A...
August 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/28754259/inflammation-regulates-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-differentially-in-specific-compartments-of-the-gut-mucosal-immune-system
#13
Peter Ergang, Martin Vodička, Karla Vagnerová, Martin Moravec, Pavlína Kvapilová, Milan Kment, Jiří Pácha
The bioavailability of glucocorticoids is modulated by enzyme 11β-hydroxysteroid dehydrogenase type 1 (11HSD1), which catalyzes the conversion of inactive 11-oxo-glucocorticoids to active 11-hydroxy-glucocorticoids cortisol and corticosterone and is regulated by pro-inflammatory cytokines. Our aim was to assess the effect of colitis on the expression of 11HSD1 in specific microanatomical compartments of the mucosal immune system. Using qRT-PCR we quantified the expression of 11HSD1 and cytokines in the colon, mesenteric lymph nodes (MLN) and spleen of mice with colitis...
October 2017: Steroids
https://www.readbyqxmd.com/read/28731595/identification-of-carboxylesterase-genes-associated-with-pyrethroid-resistance-in-the-malaria-vector-anopheles-sinensis-diptera-culicidae
#14
Xue-Mei Wu, Bo-Ying Xu, Feng-Ling Si, Jianyong Li, Zhen-Tian Yan, Zheng-Wen Yan, Xiu He, Bin Chen
BACKGROUND: Carboxylesterases (CCEs) are one of three large detoxification enzyme families. Some CCEs are active on synthetic insecticides with ester structures. Anopheles sinensis is an important malaria vector in eastern Asia. This study identified and characterized the CCE genes in the An. sinensis genome and determined CCE genes associated with pyrethroid resistance using RNA-seq and RT-qPCR, in An. sinensis from Anhui, Chongqing, and Yunnan in China. RESULTS: Fifty-seven putative CCEs were identified and placed into 3 classes, 12 subfamilies and 14 clades through phylogenetics and homology analyses...
July 21, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28722695/cardiac-cycle-efficiency-and-dicrotic-pressure-variations-new-parameters-for-fluid-therapy-a-pilot-observational-study
#15
Antonio Messina, Salvatore M Romano, Eleonora Bonicolini, Davide Colombo, Gianmaria Cammarota, Marco Chiostri, Francesco Della Corte, Paolo Navalesi, Didier Payen, Stefano Romagnoli
BACKGROUND: During a fluid challenge, the changes in cardiac performance and peripheral circulatory tone are closely related to the position of the ventricle on the Frank-Starling curve. Some patients have a good haemodynamic response to a fluid challenge, others hardly any response. The early haemodynamic effects of a fluid challenge could predict the final response before the entire fluid volume has been administered. OBJECTIVE: To assess whether a multivariate logistic regression model, including pulse pressure variation (PPV), cardiac cycle efficiency (CCE), arterial elastance and the difference between the dicrotic pressure and both systolic and mean arterial pressure (SAP - Pdic and MAP - Pdic) can predict cardiac responsiveness early during a fluid challenge in comparison with the standard procedure described elsewhere...
June 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28713062/a-prospective-study-on-second-generation-colon-capsule-endoscopy-to-detect-mucosal-lesions-and-disease-activity-in-ulcerative-colitis-with-video
#16
Hai Yun Shi, Francis K L Chan, Akira Higashimori, Moe Kyaw, Jessica Y L Ching, Heyson C H Chan, Joey C H Chan, Anthony W H Chan, Kelvin L Y Lam, Raymond S Y Tang, Justin C Y Wu, Joseph J Y Sung, Siew C Ng
BACKGROUND AND AIMS: Mucosal healing is the goal for ulcerative colitis (UC) therapy, but it needs to be confirmed via colonoscopy. Colon capsule endoscopy (CCE) is a noninvasive technique for colon investigation. Our study investigated the accuracy of second-generation CCE (CCE-2) in assessing mucosal lesions and disease activity in UC. METHODS: In this prospective study, CCE-2 and conventional colonoscopy were performed on the same day. CCE-2 reviewers and colonoscopists used the Mayo endoscopic subscore (MES) and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) to assess disease activity, and they were blinded to each other's findings...
July 14, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28674406/exposure-history-determines-pteropod-vulnerability-to-ocean-acidification-along-the-us-west-coast
#17
N Bednaršek, R A Feely, N Tolimieri, A J Hermann, S A Siedlecki, G G Waldbusser, P McElhany, S R Alin, T Klinger, B Moore-Maley, H O Pörtner
The pteropod Limacina helicina frequently experiences seasonal exposure to corrosive conditions (Ωar  < 1) along the US West Coast and is recognized as one of the species most susceptible to ocean acidification (OA). Yet, little is known about their capacity to acclimatize to such conditions. We collected pteropods in the California Current Ecosystem (CCE) that differed in the severity of exposure to Ωar conditions in the natural environment. Combining field observations, high-CO2 perturbation experiment results, and retrospective ocean transport simulations, we investigated biological responses based on histories of magnitude and duration of exposure to Ωar < 1...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28651481/anti-fibrotic-effects-of-cuscuta-chinensis-with-in-vitro-hepatic-stellate-cells-and-a-thioacetamide-induced-experimental-rat-model
#18
Jin Seoub Kim, Sushruta Koppula, Mun Jeong Yum, Gwang Mo Shin, Yun Jin Chae, Seok Min Hong, Jae Dong Lee, MinDong Song
CONTEXT: Cuscuta chinensis Lam. (Convolvulaceae) has been used as a traditional herbal remedy for treating liver and kidney disorders. OBJECTIVE: Anti-fibrotic effects of C. chinensis extract (CCE) in cellular and experimental animal models were investigated. MATERIALS AND METHODS: HSC-T6 cell viability, cell cycle and apoptosis were analysed using MTT assay, flow cytometry and Annexin V-FITC/PI staining techniques. Thioacetamide (TAA)-induced fibrosis model was established using Sprague Dawley rats (n = 10)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28603013/oxytocin-oxt-stimulated-inhibition-of-kir7-1-activity-is-through-pip2-dependent-ca-2-response-of-the-oxytocin-receptor-in-the-retinal-pigment-epithelium-in-vitro
#19
Nathaniel York, Patrick Halbach, Michelle A Chiu, Ian M Bird, De-Ann M Pillers, Bikash R Pattnaik
Oxytocin (OXT) is a neuropeptide that activates the oxytocin receptor (OXTR), a rhodopsin family G-protein coupled receptor. Our localization of OXTR to the retinal pigment epithelium (RPE), in close proximity to OXT in the adjacent photoreceptor neurons, leads us to propose that OXT plays an important role in RPE-retinal communication. An increase of RPE [Ca(2+)]i in response to OXT stimulation implies that the RPE may utilize oxytocinergic signaling as a mechanism by which it accomplishes some of its many roles...
September 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28596986/international-core-curriculum-for-capsule-endoscopy-training-courses
#20
Ignacio Fernandez-Urien, Simon Panter, Cristina Carretero, Carolyn Davison, Xavier Dray, Evgeny Fedorov, Richard Makins, Miguel Mascarenhas, Mark McAlindon, Deirdre McNamara, Hansa Palmer, Jean Francoise Rey, Jean Christophe Saurin, Uwe Seitz, Cristiano Spada, Ervin Toth, Felix Wiedbrauck, Martin Keuchel
Capsule endoscopy (CE) has become a first-line noninvasive tool for visualisation of the small bowel (SB) and is being increasingly used for investigation of the colon. The European Society of Gastrointestinal Endoscopy (ESGE) guidelines have specified requirements for the clinical applications of CE. However, there are no standardized recommendations yet for CE training courses in Europe. The following suggestions in this curriculum are based on the experience of European CE training courses directors. It is suggested that 12 hours be dedicated for either a small bowel capsule endoscopy (SBCE) or a colon capsule endoscopy (CCE) course with 4 hours for an introductory CCE course delivered in conjunction with SBCE courses...
June 2017: Endoscopy International Open
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