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Philippe Vignon, Benjamin Pegot, François Dalmay, Vanessa Jean-Michel, Simon Bocher, Erwan L'her, Jérôme Cros, Gwenaël Prat
PURPOSE: To assess the impact of computerized transthoracic echocardiography (TTE) simulation on the learning curve to achieve competency in basic critical care echocardiography (CCE). METHODS: In this prospective bicenter study, noncardiologist residents novice in ultrasound followed either a previously validated training program with adjunctive computerized simulation on a mannequin (two 3 h-sessions; Vimedix simulator, CAE Healthcare) (interventional group; n = 12) or solely the same training program (control group; n = 12)...
June 21, 2018: Intensive Care Medicine
Ang Zheng, Wenjuan Duan, Lin Zhang, Xintong Bao, Xiaoyun Mao, Zhuojun Luo, Feng Jin
In recent years, the incidence and mortality of cancer have witnessed a dramatic increase. Cancer has already caused severe economic burdens on society, especially in developing countries and has become a major public health concern. This study evaluates the medical economic burden, including total current curative expenditure (CCE) and catastrophic health expenditure (CHE) on cancer in Liaoning Province, China. A total of 252 medical institutions were investigated with multistage stratified cluster random sampling...
June 20, 2018: Cancer Medicine
Alex Mesoudi, Alex Thornton
In recent years, the phenomenon of cumulative cultural evolution (CCE) has become the focus of major research interest in biology, psychology and anthropology. Some researchers argue that CCE is unique to humans and underlies our extraordinary evolutionary success as a species. Others claim to have found CCE in non-human species. Yet others remain sceptical that CCE is even important for explaining human behavioural diversity and complexity. These debates are hampered by multiple and often ambiguous definitions of CCE...
June 13, 2018: Proceedings. Biological Sciences
Kai-Ti Chu, Yu-Chiao Liu, Min-Wen Chung, Agus Riyanto Poerwoprajitno, Gene-Hsiang Lee, Ming-Hsi Chiang
The intrinsic catalytic property of a Fe-S complex toward H2 evolution was investigated in a wide range of acids. The title complex exhibited catalytic events at -1.16 and -1.57 V (vs Fc+ /Fc) in the presence of trifluoromethanesulfonic acid (HOTf) and trifluoroacetic acid (TFA), respectively. The processes corresponded to the single reduction of the Fe-hydride-S-proton and Fe-hydride species, respectively. When anilinium acid was used, the catalysis occurred at -1.16 V, identical with the working potential of the HOTf catalysis, although the employment of anilinium acid was only capable of achieving the Fe-hydride state on the basis of the spectral and calculated results...
June 12, 2018: Inorganic Chemistry
Maliheh Moradzadeh, Azar Hosseini, Hasan Rakhshandeh, Azita Aghaei, Hamid Reza Sadeghnia
Objective: Cuscuta campestris or common dodder is a holoparasitic plant that has been valorized for treatment of liver injury and cancer prevention in traditional medicine. Recently, extract of C. campestris had shown moderate antimicrobial properties and cytotoxic effects. In this study, we examined the level of cellular oxidants, cytotoxicity, apoptosis and differentiation induced by hydroalcoholic extract of C. campestris (CCE) (12.5-200 µg/ml), as well as arsenic trioxide (As2 O3 , 50 µM), in human leukemic (HL60 and NB4) and normal polymorph nuclear cells after 72 hr treatment...
May 2018: Avicenna Journal of Phytomedicine
Jiao Li, Wai K Leung
Colon capsule endoscopy (CCE) is designed for direct visualization of the colonic mucosa through passive propulsion. The role of CCE on detection of colonic polyps has been extensively evaluated. As mucosal healing has emerged as a pivotal target for treatment of inflammatory bowel disease (IBD), there is increasing data to suggest that CCE can also be used in the monitoring of mucosal inflammation in patients with active IBD, particularly in ulcerative colitis (UC) and also in Crohn's disease (CD). Despite advantages such as its non-invasive nature, patient's comfort, safety, and access to anatomical regions not easily reached by conventional endoscopy, CE has limitations including the lack of ability to obtain biopsies or therapeutic capabilities and no control over movement...
June 4, 2018: Journal of Digestive Diseases
Naoki Hosoe, Masaru Nakano, Ken Takeuchi, Yutaka Endo, Katsuyoshi Matsuoka, Takayuki Abe, Teppei Omori, Mari Hayashida, Taku Kobayashi, Atsushi Yoshida, Shinta Mizuno, Nakazato Yoshihiro, Makoto Naganuma, Takanori Kanai, Mamoru Watanabe, Fumiaki Ueno, Yasuo Suzuki, Toshifumi Hibi, Haruhiko Ogata
Background: The usefulness of second-generation colon capsule endoscopy (CCE-2) for ulcerative colitis (UC) has not been fully demonstrated. This study aimed to develop an endoscopic severity score of UC for CCE-2. Methods: Patients diagnosed with UC were enrolled prospectively and underwent colonoscopy and CCE-2 on the same day. The collected CCE-2 videos were adopted for the development of the score. These videos were scored by 4 blinded inflammatory bowel disease experts...
May 26, 2018: Inflammatory Bowel Diseases
Dharminder Singh, Sanjeev Yadav, V M Rajesh, Pravakar Mohanty
This work was focused on finding the groundnut shell (GNS) gasification performance in a fluidized bed gasifier with bubbling air as gasification medium. Groundnut shell in powder form (a mixture of different particle size as given in Table 8) was gasified using naturally available river sand as bed material, top of the bed feeding, conventional charcoal as bed heating medium, and two cyclones for proper cleaning and cooling the product gas. Experiments were performed using different operating conditions such as equivalence ratio (ER) between 0...
May 14, 2018: Environmental Technology
Shumin Ding, Xuefeng Hou, Fujing Wang, Gang Wang, Xiaobin Tan, Ying Liu, Yuanli Zhou, Huihui Qiu, E Sun, Nan Jiang, Zihao Li, Jie Song, Liang Feng, Xiaobin Jia
Cigarette smoking extract (CSE)-induced autophagic injury has been regarded as an important contributor to the pathogenesis of lung cancer. We previously found that Eclipta prostrata L. component (CCE) reduced CSE-induced bronchial epithelial cells damage. However, the mechanism remains unknown. Human normal bronchial epithelial cells (NHBE) were exposed to CSE to establish stress model. Nrf2-siRNA and Keap1-siRNA transfection were performed. mRFP-GFP-LC3 dual fluorescence and transmission electron microscopy were used to observe the autophagic characteristics...
May 4, 2018: Environmental Toxicology
Shinji Okabayashi, Taku Kobayashi, Masaru Nakano, Takahiko Toyonaga, Ryo Ozaki, Maria Carla Tablante, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi
Background: Second-generation colon capsule endoscopy (CCE-2) has been reported as a potential tool for monitoring ulcerative colitis (UC). However, its excretion rate is still unsatisfactory, and the bowel preparation regimen is not well tolerated. Furthermore, a standard bowel preparation regimen validated for UC has not been established. The aim of this study was to develop a simple 1-day CCE-2 procedure while evaluating its excretion rate and acceptability in UC. Factors associated with the colonic transit time and acceptability of CCE-2 were evaluated...
April 30, 2018: Inflammatory Bowel Diseases
Victoria Blanes-Vidal, Esmaeil S Nadimi, Maria Magdalena Buijs, Gunnar Baatrup
PURPOSE: Colon capsule endoscopy (CCE) is considered a potential alternative to optical colonoscopy (OC) for colorectal cancer screening. However, the accuracy of CCE in polyp size and morphology estimation is unknown. METHODS: A fully paired study was performed (2015-2016), where 255 participants from the Danish national screening program had CCE, OC, and histopathology (HP) of all detected polyps. We developed a new algorithm to match CCE and OC polyps, based on objective measures of similarity between polyps...
May 1, 2018: International Journal of Colorectal Disease
Fauzan Alam Hashmi, Hamid Hussain Rai, Muhammad Faheem Khan, Muhammad Ehsan Bari
Background: Clear cell variant in ependymal tumors is rare. We aimed to compare the features and outcome of the World Health Organization (WHO) Grade 3 ependymal tumors with clear cells to the WHO Grade 3 classic anaplastic ependymoma (AE). Materials and Methods: A retrospective cohort study conducted at the Department of Neurosurgery, Aga Khan University, Pakistan, from 2003 to 2013. The medical records and radiology of patients with proven histopathology were reviewed...
April 2018: Asian Journal of Neurosurgery
Mi-Jin Yim, Jeong Min Lee, Grace Choi, Dae-Sung Lee, Won Sun Park, Won-Kyo Jung, Saegwang Park, Su-Kil Seo, Jungik Park, Il-Whan Choi, Sun Young Ma
Marine algae have valuable health and dietary benefits. The present study aimed to investigate whether an ethanol extract of Carpomitra costata (CCE) could inhibit the inflammatory response to LPS. CCE attenuated the production of proinflammatory mediators, such as prostaglandin E2 (PGE2 ) and nitric oxide (NO), by inhibiting inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in LPS-induced RAW264.7 macrophages. CCE also inhibited the expression of proinflammatory cytokines such as IL-1 β , TNF- α , and IL-6...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Daniel Blustein, Adam Wilson, Jon Sensinger
Advanced neural interfaces show promise in making prosthetic limbs more biomimetic and ultimately more intuitive and useful for patients. However, approaches to assess these emerging technologies are limited in scope and the insight they provide. When outfitting a prosthesis with a feedback system, such as a peripheral nerve interface, it would be helpful to quantify its physiological correspondence, i.e. how well the prosthesis feedback mimics the perceived feedback in an intact limb. Here we present an approach to quantify this aspect of feedback quality using the crossmodal congruency effect (CCE) task...
April 18, 2018: Scientific Reports
Shabana F Pasha
PURPOSE OF REVIEW: This is a review of colon capsule endoscopy (CCE) with a focus on its recent developments, technological improvements, and current and potential future indications. RECENT FINDINGS: Based on the current literature, CCE II demonstrates comparable polyp detection rates as optical colonoscopy and CT colonography, and improved cost-effectiveness. The main limitation to patient acceptance is the requirement of a rigorous bowel preparation. Preliminary studies show good correlation between CCE and optical colonoscopy for assessment of colonic disease activity in inflammatory bowel disease (IBD)...
April 12, 2018: Current Gastroenterology Reports
Koji Murono, Kazushige Kawai, Keisuke Hata, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Takeshi Nishikawa, Kensuke Otani, Toshiaki Tanaka, Masako Ikemura, Hiroaki Nozawa
BACKGROUND: Cholesterol crystal embolism (CCE) is caused by small crystals of cholesterol dispersed from atherosclerotic plaques of the aorta. There is an increasing interest in CCE because of the increased use of endovascular treatments. Here, we report a rare case of intestinal stenosis caused by CCE after functional end-to-end anastomosis (FEEA). To our knowledge, this is the first report of CCE causing such an anastomotic stenosis. CASE PRESENTATION: A 77-year-old male patient underwent laparoscopy-assisted low anterior resection and protective ileostomy for rectal carcinoid tumor...
April 4, 2018: Surgical Case Reports
Ning Liu, Yalin Zhang, Han Su, Jinrong Wang, Zuwang Liu, Juan Kong
There was evidence that 1,25(OH)2 D3 regulated aquaporin (AQP) 2 and 4 expression while ameliorating renal fibrosis. This study investigated whether cholecalciferol cholesterol emulsion (CCE), a precursor of 1,25(OH)2 D3 , has similar effects. The impact of CCE on renal fibrosis and AQP2 and AQP4 expression were studied in a unilateralureteral obstruction (UUO) mouse nephropathy model. CCE reduced both the extent of fibrosis and transforming growth factor (TGF)-β signaling compared with vehicle-treated UUO model controls...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Saad Omais, Carine Jaafar, Noël Ghanem
Adult neurogenesis (AN) is an ongoing developmental process that generates newborn neurons in the olfactory bulb (OB) and the hippocampus (Hi) throughout life and significantly contributes to brain plasticity. Adult neural stem and progenitor cells (aNSPCs) are relatively limited in number and fate and are spatially restricted to the subventricular zone (SVZ) and the subgranular zone (SGZ). During AN, the distinct roles played by cell cycle proteins extend beyond cell cycle control and constitute key regulatory mechanisms involved in neuronal maturation and survival...
2018: Frontiers in Neuroscience
Shumin Ding, Xuefeng Hou, Gang Wang, Huihui Qiu, Ying Liu, Yuanli Zhou, Mei Du, Xiaobin Tan, Jie Song, Yingjie Wei, Luan Shu, Zhiyong Li, Liang Feng, Xiaobin Jia
Excessive autophagy plays a crucial role in cigarette smoking extract (CSE)-induced inflammation response and oxidative damage of respiratory epithelial cells. The components from Eclipta prostrata L. (CCE) have been shown to be beneficial for CSE-induced epithelial cells injury. However, whether its protection on CSE-stress injury is related to its regulation on autophagy remains still unclear. In this study, CCE, containing mainly wedelolactone of 45.88% and demethylwedelolactone of 23.74%, could improve significantly 10%CSE-induced cell viability of normal human bronchial epithelial (NHBE) cells using CCK-8 kit...
2018: Frontiers in Pharmacology
Begoña González-Suárez, Sonia Rodriguez, Elena Ricart, Ingrid Ordás, Jordi Rimola, Álvaro Díaz-González, Cristina Romero, Cristina Rodríguez de Miguel, Arantxa Jáuregui, Isis K Araujo, Anna Ramirez, Marta Gallego, Gloria Fernández-Esparrach, Ángels Ginés, Oriol Sendino, Josep Llach, Julian Panés
Background and Aims: Diagnostic yield of Small Bowel Capsule Endoscopy (SBCE) for the assessment of small bowel (SB) lesions is higher than radiologic imaging techniques. However, magnetic resonance enterography (MRE) data are scarce and inconclusive. Colon Capsule Endoscopy (CCE) is a new capsule modality. The primary aim of our study was to compare MRE and capsule endoscopy (CE) for the assessment of Crohn's disease (CD). The secondary objectives were to compare the diagnostic accuracy of both CE modalities and changes in Montreal classification after each examination...
March 19, 2018: Inflammatory Bowel Diseases
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