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Oxidative stress aneurysm

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https://www.readbyqxmd.com/read/28808955/exploring-the-biological-and-mechanical-properties-of-abdominal-aortic-aneurysms-using-uspio-mri-and-peak-tissue-stress-a-combined-clinical-and-finite-element-study
#1
Noel Conlisk, Rachael O Forsythe, Lyam Hollis, Barry J Doyle, Olivia M B McBride, Jennifer M J Robson, Chengjia Wang, Calum D Gray, Scott I K Semple, Tom MacGillivray, Edwin J R van Beek, David E Newby, Peter R Hoskins
Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm...
August 14, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28735510/fxa-inhibition-by-rivaroxaban-modifies-mechanisms-associated-with-the-pathogenesis-of-human-abdominal-aortic-aneurysms
#2
G Moñux, J J Zamorano-León, P Marqués, B Sopeña, J M García-García, G Laich de Koller, B Calvo-Rico, M A García-Fernandez, J Serrano, A López-Farré
AIM: To evaluate if Rivaroxaban, an oral factor Xa (FXa) inhibitor, could in vitro modify the expression of inflammatory and oxidative stress biomarkers in abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. METHODS: AAA sites with intraluminal mural thrombus were obtained from six patients undergoing elective AAA repair. In addition, control abdominal aortic samples were obtained from six organ donors. AAA sites were incubated in the presence and absence of 50 nmol/L Rivaroxaban...
July 23, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28725903/suppressive-effects-of-dietary-epa-rich-fish-oil-on-the-degradation-of-elastin-fibers-in-the-aortic-wall-in-nicotine-administered-mice
#3
Hirona Kugo, Nobuhiro Zaima, Megumi Onozato, Chie Miyamoto, Keisuke Hashimoto, Kenichi Yanagimoto, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta. Recent studies suggest that nicotine, which is a primary component in cigarette smoke, is closely associated with the development and rupture of an AAA. Nicotine accelerates AAA development through the weakening of the vascular wall by increasing oxidative stress and matrix metalloproteinase (MMP)-2 expression. However, little is known about preventing the AAA induced by nicotine. A non-surgical means of preventing the weakening of the vascular wall before the onset of AAA by functional food factors would be a valuable option over surgery...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28721338/is-aortic-aneurysm-preventable
#4
Undurti N Das
Abdominal aortic aneurysm (AAA) is a chronic inflammatory condition, triggered by the local accumulation of macrophages, oxidative stress and damage to the aortic wall. Pro-inflammatory eicosanoids seem to play a significant role in AAA. The pro-inflammatory events seen in AAA could be due to a deficiency of anti-inflammatory eicosanoids such as lipoxin A4 (LXA4), resolvins, protectins and maresins as a result of reduced tissue concentrations of their precursors: arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)...
June 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28713907/roles-of-mir%C3%A2-4463-in-h2o2%C3%A2-induced-oxidative-stress-in-human-umbilical-vein-endothelial-cells
#5
Xueqin Wang, Xuemei He, Xian Deng, Yanzheng He, Xiangyu Zhou
Oxidative stress is implicated in the pathophysiology of vascular diseases, including atherosclerosis, aneurysm and arteriovenous fistula. A previous study from our lab suggested that microRNA (miR)‑4463 may be involved in the pathogenesis of vascular disease; however, the roles of oxidative stress in the molecular mechanisms underlying the actions of miR‑4463 in vascular disease have yet to be elucidated. The aim of the present study was to investigate the role of miR‑4463 in hydrogen peroxide (H2O2)‑induced oxidative stress in human umbilical vein endothelial cells (HUVECs)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28655550/skin-accumulation-of-advanced-glycation-end-products-is-increased-in-patients-with-an-abdominal-aortic-aneurysm
#6
Jeltje Boersema, Lisanne C de Vos, Thera P Links, Douwe J Mulder, Andries J Smit, Clark J Zeebregts, Joop D Lefrandt
OBJECTIVE: Advanced glycation end products (AGEs) are implicated in the pathogenesis of cardiovascular disease. Accumulation of AGEs is driven by oxidative or glycemic stress and can be assessed by skin autofluorescence (SAF). SAF is increased in patients with peripheral artery disease (PAD) and independently associated with mortality and major adverse cardiovascular events in these patients. PAD and abdominal aortic aneurysm (AAA) share several risk factors. Inflammation is an important process in AAA formation and increases levels of oxidative stress...
June 24, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28651938/elevated-oxidative-stress-in-the-aortic-media-of-patients-with-bicuspid-aortic-valve
#7
Marie Billaud, Julie A Phillippi, Mary P Kotlarczyk, Jennifer C Hill, Bradley W Ellis, Claudette M St Croix, Nadiezhda Cantu-Medéllin, Eric E Kelley, Thomas G Gleason
OBJECTIVE: Congenital bicuspid aortic valve (BAV) is distinctly associated with the development of ascending aortopathy in adulthood, portending risk of both ascending aortic aneurysm and dissection. Our previous work implicated deficiency in oxidative stress response as a mediator of the BAV-associated aortopathy. We hypothesize that reactive oxygen species generation invokes elevated local oxidative tissue damage in ascending aorta of patients with BAV. METHODS: Ascending aortic specimens were obtained from patients undergoing elective aortic replacement and/or aortic valve replacement and during heart transplant operations...
May 25, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28545777/inhibitory-effects-of-doxycycline-on-the-onset-and-progression-of-abdominal-aortic-aneurysm-and-its-related-mechanisms
#8
Maomao Yu, Cong Chen, Yini Cao, Rong Qi
The objective of this study was to investigate whether doxycycline (DOX) given at different doses and via different administration routes had protective or therapeutic effects on abdominal aortic aneurysm (AAA) induced by elastase in mice. Moreover, the anti-AAA mechanism of DOX was studied in TNF-α-stimulated vascular smooth muscle cell (VSMC) in vitro. For in vivo study, either daily administration of 30mg/kg of DOX by gavage or intraperitoneal injection of 15mg/kg DOX every other day for 14 days significantly prevented the development of AAA at its early stage...
May 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28525804/recombinant-adeno-associated-virus-vector-carrying-the-thrombomodulin-lectin-like-domain-for-the-treatment-of-abdominal-aortic-aneurysm
#9
Chao-Han Lai, Kuan-Chieh Wang, Cheng-Hsiang Kuo, Fang-Tzu Lee, Tsung-Lin Cheng, Bi-Ing Chang, Yu-Jen Yang, Guey-Yueh Shi, Hua-Lin Wu
BACKGROUND AND AIMS: Thrombomodulin (TM), through its lectin-like domain (TMD1), sequesters proinflammatory high-mobility group box 1 (HMGB1) to prevent it from engaging the receptor for advanced glycation end product (RAGE) that sustains inflammation and tissue damage. Our previous study demonstrated that short-term treatment with recombinant TM containing all the extracellular domains (i.e., rTMD123) inhibits HMGB1-RAGE signaling and confers protection against CaCl2-induced AAA formation...
March 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28473982/the-association-of-serum-thrombomodulin-with-endothelial-injuring-factors-in-abdominal-aortic-aneurysm
#10
Magdalena Budzyń, Bogna Gryszczyńska, Wacław Majewski, Zbigniew Krasiński, Magdalena Paulina Kasprzak, Dorota Formanowicz, Krzysztof Wojciech Strzyżewski, Maria Iskra
Background. The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury. Materials and Methods. Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtained in 30 healthy age- and sex-matched volunteers...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28468328/heparin-and-heparin-derivatives-in-post-subarachnoid-hemorrhage-brain-injury-a-multimodal-therapy-for-a-multimodal-disease
#11
REVIEW
Erik G Hayman, Akil P Patel, Robert F James, J Marc Simard
Pharmacologic efforts to improve outcomes following aneurysmal subarachnoid hemorrhage (aSAH) remain disappointing, likely owing to the complex nature of post-hemorrhage brain injury. Previous work suggests that heparin, due to the multimodal nature of its actions, reduces the incidence of clinical vasospasm and delayed cerebral ischemia that accompany the disease. This narrative review examines how heparin may mitigate the non-vasospastic pathological aspects of aSAH, particularly those related to neuroinflammation...
May 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28456915/reversible-cerebral-vasoconstriction-syndrome-recognition-and-treatment
#12
REVIEW
Cecilia Cappelen-Smith, Zeljka Calic, Dennis Cordato
Reversible cerebral vasoconstriction syndrome (RCVS) is a rare but increasingly recognized disorder with over 500 cases published in the literature. The condition is characterized by recurrent severe thunderclap headaches with or without other neurological symptoms and diffuse segmental narrowing of the cerebral arteries which is reversible within 3 months. RCVS may occur spontaneously but in over 50% of cases, it is associated with various other conditions, including vasoactive medications or illicit drugs and the post-partum state...
June 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28450452/nanonet-force-microscopy-for-measuring-forces-in-single-smooth-muscle-cells-of-the-human-aorta
#13
Alexander Hall, Patrick Chan, Kevin Sheets, Matthew Apperson, Christopher Delaughter, Thomas G Gleason, Julie A Phillippi, Amrinder Nain
A number of innovative methods exist to measure cell-matrix adhesive forces, but they have yet to accurately describe and quantify the intricate interplay of a cell and its fibrous extracellular matrix (ECM). In cardiovascular pathologies, such as aortic aneurysm, new knowledge on the involvement of cell-matrix forces could lead to elucidation of disease mechanisms. To better understand this dynamics, we measured primary human aortic single smooth muscle cell (SMC) forces using nanonet force microscopy in both inside-out (I-O intrinsic contractility) and outside-in (O-I external perturbation) modes...
July 7, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28430357/reactive-oxygen-species-key-regulators-in-vascular-health-and-diseases
#14
REVIEW
Qishan Chen, Qiwen Wang, Jianhua Zhu, Qingzhong Xiao, Li Zhang
Reactive oxygen species (ROS) are a group of small reactive molecules that play critical roles in the regulation of various cell functions and biological processes. In the vascular system, physiological levels of ROS are essential for normal vascular functions including endothelial homeostasis and smooth muscle cell contraction. In contrast, uncontrolled overproduction of ROS resulted from imbalance of ROS generation and elimination, leads to the development of vascular diseases. Excessive ROS cause vascular cell damages, recruitment of inflammatory cells, lipid peroxidation, activation of metalloproteinases, and deposition of extracellular matrix, collectively leading to vascular remodeling...
April 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28408198/plasma-8-iso-prostaglandin-f2%C3%AE-a-possible-prognostic-marker-in-aneurysmal-subarachnoid-hemorrhage
#15
De-Sheng Pan, Min Yan, Muhammad Hassan, Ze-Bin Fang, Man-Tao Chen
BACKGROUND: 8-iso-Prostaglandin F2α (8-iso-PGF2α) is a potential biomarker of oxidative stress. This study clarified whether plasma 8-iso-PGF2α concentrations were affected and its underlying relevance to prognosis in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: In this prospective, observational study, a total of 170 controls and 170 aSAH patients were enrolled. Plasma 8-iso-PGF2α concentrations were detected using an ELISA. Severity was assessed by World Federation of Neurological Surgeons (WFNS) scale and modified Fisher grading scale...
April 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28356339/nicotinamide-phosphoribosyltransferase-in-smooth-muscle-cells-maintains-genome-integrity-resists-aortic-medial-degeneration-and-is-suppressed-in-human-thoracic-aortic-aneurysm-disease
#16
Alanna Watson, Zengxuan Nong, Hao Yin, Caroline O'Neil, Stephanie Fox, Brittany Balint, Linrui Guo, Oberdan Leo, Michael W A Chu, Robert Gros, J Geoffrey Pickering
RATIONALE: The thoracic aortic wall can degenerate over time with catastrophic consequences. Vascular smooth muscle cells (SMCs) can resist and repair artery damage, but their capacities decline with age and stress. Recently, cellular production of nicotinamide adenine dinucleotide (NAD(+)) via nicotinamide phosphoribosyltransferase (Nampt) has emerged as a mediator of cell vitality. However, a role for Nampt in aortic SMCs in vivo is unknown. OBJECTIVES: To determine whether a Nampt-NAD(+) control system exists within the aortic media and is required for aortic health...
June 9, 2017: Circulation Research
https://www.readbyqxmd.com/read/28318957/oceanic-meteorological-conditions-influence-incidence-of-aneurysmal-subarachnoid-hemorrhage
#17
Thierry Patrice, Bertrand Rozec, Hubert Desal, Yvonnick Blanloeil
OBJECTIVE: Publications concerning the weather pattern of occurrence of the subarachnoid hemorrhage have produced controversial results. We chose to study subarachnoid hemorrhage occurring in oceanic climate with deep variations focusing on partial oxygen volume (pO2) and patient history. METHODS: Seventy-one patients had been successively recruited from a single center 45 km from the Atlantic shore. Climate conditions had been analyzed from 72 hours before subarachnoid hemorrhage to 24 hours after...
March 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28288701/abdominal-aortic-aneurysm-and-omega-3-polyunsaturated-fatty-acids-mechanisms-animal-models-and-potential-treatment
#18
REVIEW
Lara T Meital, Shaun L Sandow, Philip C Calder, Fraser D Russell
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with macrophage accumulation in the adventitia, oxidative stress, medial elastin degradation and aortic dilation. Progression of AAA is linked to increased risk of rupture, which carries a high mortality rate. Drug therapies trialled to date lack efficacy and although aneurysm repair is available for patients with large aneurysm, peri-surgical morbidity and mortality have been widely reported. Recent studies using rodent models of AAA suggest that long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) and their metabolites can moderate inflammation and oxidative stress perpetuated by infiltrating macrophages and intervene in the destruction of medial elastin...
March 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28242497/toxicological-effects-of-graphene-oxide-on-adult-zebrafish-danio-rerio
#19
Jaqueline P Souza, Jéssica F Baretta, Fabrício Santos, Ieda M M Paino, Valtencir Zucolotto
Graphene exhibits unique physical and chemical properties that facilitate its application in many fields, including electronics and biomedical areas. However, the use of graphene and its derivatives could result in accumulation in aquatic environments, and the risks posed by these compounds for organisms are not completely understood. In this study, we investigated the effects of graphene oxide (GO) on adult zebrafish (Danio rerio). Experimental fish were exposed to 2, 10 or 20mgL(-1) GO, and the cytotoxicity, genotoxicity and oxidative stress were assessed...
May 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28185644/bicuspid-aortic-valve-morphotype-correlates-with-regional-antioxidant-gene%C3%A2-expression-profiles-in-the-proximal%C3%A2-ascending-aorta
#20
Julie A Phillippi, Jennifer C Hill, Marie Billaud, Benjamin R Green, Mary P Kotlarczyk, Thomas G Gleason
BACKGROUND: Bicuspid aortic valve (BAV) is associated with asymmetric dilatation of the proximal ascending aorta. We previously demonstrated increased susceptibility of smooth muscle cells to oxidative stress in the BAV-aneurysmal aorta and hypothesized that antioxidant expression is regionally defined and influenced by the BAV morphotype. METHODS: BAV valve morphology was defined according to number of raphes: type 0 (0 raphes), type 1 (1 raphe), or type 2 (2 raphes) and by the raphe location among the left (L), right (R) or non (N) coronary cusps...
February 6, 2017: Annals of Thoracic Surgery
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