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Oxidative stress aneurysm

Johanna Herajärvi, Tuomas Anttila, Henna Sarja, Caius Mustonen, Henri Haapanen, Tuomas Mäkelä, Fredrik Yannopoulos, Tuomo Starck, Mika Kallio, Hannu Tuominen, Ulla Puistola, Peeter Karihtala, Kai Kiviluoma, Vesa Anttila, Tatu Juvonen
BACKGROUND: Paraplegia is one of the most severe complications occurring after the repair of thoracic and thoracoabdominal aortic aneurysms. Remote ischemic preconditioning (RIPC) has been shown to mitigate neurologic damage, and this study assessed its efficacy in preventing spinal cord ischemia. METHODS: The study randomized 16 female pigs into an RIPC group (n = 8) and a control group (n = 8). The RIPC group underwent four cycles of 5-minute ischemia-reperfusion episodes by intermittent occlusion of the left iliac artery...
September 22, 2016: Annals of Thoracic Surgery
Kak Khee Yeung, Menno Groeneveld, Joyce Ja-Ning Lu, Pepijn van Diemen, Vincent Jongkind, Willem Wisselink
Open surgical repair of an aortic aneurysm requires aortic cross-clamping, resulting in temporary ischemia of all organs and tissues supplied by the aorta distal to the clamp. Major complications of open aneurysm repair due to aortic cross-clamping include renal ischemia-reperfusion injury and postoperative colonic ischemia in case of supra- and infrarenal aortic aneurysm repair. Ischemia-reperfusion injury results in excessive production of reactive oxygen species and in oxidative stress, which can lead to multiple organ failure...
September 2016: Best Practice & Research. Clinical Anaesthesiology
Wei-Wei Lu, Li-Xin Jia, Xian-Qiang Ni, Lei Zhao, Jin-Rui Chang, Jin-Sheng Zhang, Yue-Long Hou, Yi Zhu, You-Fei Guan, Yan-Rong Yu, Jie Du, Chao-Shu Tang, Yong-Fen Qi
OBJECTIVE: Oxidative stress plays a critical role in the development of abdominal aortic aneurysm (AAA). Intermedin (IMD) is a regulator of oxidative stress. Here, we investigated whether IMD reduces AAA by inhibiting oxidative stress. APPROACH AND RESULTS: In angiotensin II-induced ApoE(-) (/-) mouse and CaCl2-induced C57BL/6J mouse model of AAA, IMD1- 53 significantly reduced the incidence of AAA and maximal aortic diameter. Ultrasonography, hematoxylin, and eosin staining and Verhoeff-van Gieson staining showed that IMD1- 53 significantly decreased the enlarged aortas and elastic lamina degradation induced by angiotensin II or CaCl2...
September 15, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Yen-Chun Ho, Meng-Ling Wu, Pei-Yu Gung, Chung-Huang Chen, Cheng-Chin Kuo, Shaw-Fang Yet
Abdominal aortic aneurysm (AAA) is a chronic but often fatal disease in elderly population. Heme oxygenase-1 (HO-1) is a stress response protein with antioxidative and anti-inflammatory properties. HO-1 has been shown to protect against atherogenesis and arterial intimal thickening. Emerging evidences suggest that AAA and arterial occlusive disease have distinct pathogenic mechanisms. Thus, in this study we investigated the role of HO-1 in angiotensin II-induced AAA formation in HO-1+/+apoE-/- and HO-1-/-apoE-/- mice...
September 8, 2016: Oncotarget
Jiaze Li, Smriti Murali Krishna, Jonathan Golledge
Abdominal aortic aneurysm (AAA) is a vascular condition that causes permanent dilation of the abdominal aorta, which can lead to death due to aortic rupture. The only treatment for AAA is surgical repair, and there is no current drug treatment for AAA. Aortic inflammation, vascular smooth muscle cell apoptosis, angiogenesis, oxidative stress and vascular remodeling are implicated in AAA pathogenesis. Kallistatin is a serine proteinase inhibitor, which has been shown to have a variety of functions, potentially relevant in AAA pathogenesis...
2016: International Journal of Molecular Sciences
Shyamala Thirunavukkarasu, Nayaab S Khan, Chi Young Song, Hafiz U Ghafoor, David D Brand, Frank J Gonzalez, Kafait U Malik
Cytochrome P450 (CYP) 1B1 is implicated in vascular smooth muscle cell migration, proliferation, and hypertension. We assessed the contribution of CYP1B1 to angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA). Male Apoe(-/-)/Cyp1b1(+/+) and Apoe(-/-)/Cyp1b1(-/-) mice were infused with Ang II or its vehicle for 4 weeks; another group of Apoe(-/-)/Cyp1b1(+/+) mice was coadministered the CYP1B1 inhibitor 2,3',4,5'-tetramethoxystilbene (TMS) every third day for 4 weeks. On day 28 of Ang II infusion, AAAs were analyzed by ultrasound and ex vivo by Vernier calipers, mice were euthanized, and tissues were harvested...
August 2016: American Journal of Pathology
Guglielmina Pepe, Betti Giusti, Elena Sticchi, Rosanna Abbate, Gian Franco Gensini, Stefano Nistri
Marfan syndrome (MFS) is a pleiotropic connective tissue disease inherited as an autosomal dominant trait, due to mutations in the FBN1 gene encoding fibrillin 1. It is an important protein of the extracellular matrix that contributes to the final structure of a microfibril. Few cases displaying an autosomal recessive transmission are reported in the world. The FBN1 gene, which is made of 66 exons, is located on chromosome 15q21.1. This review, after an introduction on the clinical manifestations that leads to the diagnosis of MFS, focuses on cardiovascular manifestations, pharmacological and surgical therapies of thoracic aortic aneurysm and/or dissection (TAAD), mechanisms underlying the progression of aneurysm or of acute dissection, and biomarkers associated with progression of TAADs...
2016: Application of Clinical Genetics
Uma Maheswari Balaguru, Lakshmikirupa Sundaresan, Jeganathan Manivannan, Reji Majunathan, Krishnapriya Mani, Akila Swaminathan, Saravanakumar Venkatesan, Dharanibalan Kasiviswanathan, Suvro Chatterjee
Disturbed fluid flow or modulated shear stress is associated with vascular conditions such as atherosclerosis, thrombosis, and aneurysm. In vitro simulation of the fluid flow around the plaque micro-environment remains a challenging approach. Currently available models have limitations such as complications in protocols, high cost, incompetence of co-culture and not being suitable for massive expression studies. Hence, the present study aimed to develop a simple, versatile model based on Computational Fluid Dynamics (CFD) simulation...
2016: Scientific Reports
Cristiano Spadaccio, Raffaella Coccia, Marzia Perluigi, Gilda Pupo, Maria Eugenia Schininà, Alessandra Giorgi, Carla Blarzino, Francesco Nappi, Fraser W Sutherland, Massimo Chello, Fabio Di Domenico
OBJECTIVES: oxidative stress is undoubtedly one of the main players in abdominal aortic aneurysm (AAA) pathophysiology. Recent studies in AAA patients reported an increase in the indices of oxidative damage at the tissue level and in biological fluids coupled with the loss of counter-regulatory mechanisms of protection from oxidative stress. We recently reported, in a proteomic analysis of AAA patient sera, changes in the expression of several proteins exerting important modulatory activities on cellular proliferation, differentiation and response to damage...
June 21, 2016: Molecular BioSystems
Sili Zou, Pingping Ren, Lin Zhang, Alon R Azares, Sui Zhang, Joseph S Coselli, Ying H Shen, Scott A LeMaire
BACKGROUND: Insufficient aortic protection and repair may contribute to the development of aortic aneurysms and dissections (AAD). However, mechanisms of aortic protection and repair are poorly understood. We have shown that the multifunctional kinase AKT2 plays an important role in protecting the aortic wall. Here, we examined whether AKT2 protects against AAD by promoting bone marrow cell (BMC)-mediated aortic protection. METHODS: Irradiated wild-type mice received green fluorescent protein-expressing BMCs from wild-type mice or Akt2(-/-) mice, followed by challenge with angiotensin II (1000 ng/kg/min) infusion for 4 weeks...
June 2016: Annals of Thoracic Surgery
Hirona Kugo, Nobuhiro Zaima, Youhei Mouri, Hiroki Tanaka, Kenichi Yanagimoto, Tetsumei Urano, Naoki Unno, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta and high rupture-related mortality rates. AAA is histologically characterized by oxidative stress, chronic inflammation, and extracellular matrix degradation in the vascular wall. We previously demonstrated that aortic hypoperfusion could cause the vascular inflammation and AAA formation. However, the preventive method for hypoperfusion-induced AAA remains unknown. In this study, we evaluated the effect of fish oil on AAA development using a hypoperfusion-induced AAA animal model...
June 2016: Bioscience, Biotechnology, and Biochemistry
Özde Cem, Samet Yilmaz, Ahmet Korkmaz, Turna Fahrettin, Ilker Sahin, Vahit Demir
BACKGROUND: Ascending aortic dilatation (AAD), more often encountered in hypertensive individuals compared with normotensive individuals, is an important cause of mortality in adults. Neutrophil-to-lymphocyte ratio (NLR), as an oxidative stress and proinflammatory marker, has recently emerged as a useful indicator to predict cardiovascular risk and adverse outcomes. The aim of our study was to investigate the relationship between NLR and AAD in patients with hypertension. METHODS: A total of 135 newly diagnosed and untreated hypertensive patients were enrolled in this study...
August 2016: Blood Pressure Monitoring
Elena Burillo, Carlos Tarin, Monica-Maria Torres-Fonseca, Carlos-Ernesto Fernandez-García, Roxana Martinez-Pinna, Diego Martinez-Lopez, Patricia Llamas-Granda, Emilio Camafeita, Juan Antonio Lopez, Melina Vega de Ceniga, Michael Aviram, Jesus Egido, Luis-Miguel Blanco-Colio, Jose-Luis Martín-Ventura
Abdominal aortic aneurysm (AAA) is a permanent dilation of the aorta due to excessive proteolytic, oxidative and inflammatory injury of the aortic wall. We aimed to identify novel mediators involved in AAA pathophysiology, which could lead to novel therapeutic approaches. For that purpose, plasma from four AAA patients and four controls were analysed by a label-free proteomic approach. Among identified proteins, paraoxonase-1 (PON1) was decreased in plasma of AAA patients compared with controls, which was further validated in a bigger cohort of samples by ELISA...
June 1, 2016: Clinical Science (1979-)
Honglin Niu, Ying Li, Haibin Li, Yanqing Chi, Minghui Zhuang, Tao Zhang, Maodong Liu, Lei Nie
Obesity-induced kidney injury contributes to albuminuria, which is characterized by a progressive decline in renal function leading to glomerulosclerosis and renal fibrosis. Matrix metalloproteinases (MMPs) modulate inflammation and fibrosis by degrading a variety of extracellular matrix and regulating the activities of effector proteins. Abnormal regulation of MMP-12 expression has been implicated in abdominal aortic aneurysm, atherosclerosis, and emphysema, but the underlying mechanisms remain unclear. The present study examined the function of MMP-12 in glomerular fibrogenesis and inflammation using apo E(-/-) or apo E(-/-)MMP-12(-/-) mice and maintained on a high-fat-diet (HFD) for 3, 6, or 9 months...
2016: Scientific Reports
Theophilus I Emeto, Joseph V Moxon, Minnie Au, Jonathan Golledge
Abdominal aortic aneurysm (AAA) is a significant cause of mortality in older adults. A key mechanism implicated in AAA pathogenesis is inflammation and the associated production of reactive oxygen species (ROS) and oxidative stress. These have been suggested to promote degradation of the extracellular matrix (ECM) and vascular smooth muscle apoptosis. Experimental and human association studies suggest that ROS can be favourably modified to limit AAA formation and progression. In the present review, we discuss mechanisms potentially linking ROS to AAA pathogenesis and highlight potential treatment strategies targeting ROS...
March 2016: Clinical Science (1979-)
Matthew Amin, Sathnur Pushpakumar, Nino Muradashvili, Sourav Kundu, Suresh C Tyagi, Utpal Sen
Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose main function is to degrade and deposit structural proteins within the extracellular matrix (ECM). A dysregulation of MMPs is linked to vascular diseases. MMPs are classified into collagenases, gelatinases, membrane-type, metalloelastase, stromelysins, matrilysins, enamelysins, and unclassified subgroups. The production of MMPs is stimulated by factors such as oxidative stress, growth factors and inflammation which lead to its up- or down-regulation with subsequent ECM remodeling...
2016: Frontiers in Bioscience (Landmark Edition)
Corinna S Bürgin-Maunder, Maria Nataatmadja, Rebecca K Vella, Andrew S Fenning, Peter R Brooks, Fraser D Russell
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease. Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) decrease inflammation and oxidative stress in an angiotensin II-infused apolipoprotein E-knockout (ApoE(-/-)) mouse model of AAA. This study investigated the effects of LC n-3 PUFAs on blood pressure and vascular reactivity in fourteen angiotensin II-infused ApoE(-/-) male mice. Blood pressure was obtained using a non-invasive tail cuff method and whole blood was collected by cardiac puncture...
February 2016: Clinical and Experimental Pharmacology & Physiology
A Ramesh, P A Prins, P R Perati, P V Rekhadevi, U K Sampson
As exposure to polycyclic aromatic hydrocarbons (PAHs; a family of environmental toxicants) have been implicated in cardiovascular diseases, the ability of the aortic tissue to process these toxicants is important from the standpoint of abdominal aortic aneurysms and atherosclerosis. Benzo(a)pyrene (B(a)P), a representative PAH compound is released into the environment from automobile exhausts, industrial emissions, and considerable intake of B(a)P is also expected in people who are smokers and barbecued red meat eaters...
January 2016: Molecular and Cellular Biochemistry
Hung-Wen Kao, Kwo-Whei Lee, Wei-Liang Chen, Chen-Ling Kuo, Ching-Shan Huang, Wan-Min Tseng, Chin-San Liu, Ching-Po Lin
Cyclophilin A (CyPA), an oxidative stress-induced factor, was found to play an important role in the aneurysm formation. Our working hypothesis was that the plasma level of CyPA in ruptured intracranial aneurysm could predict the neurological outcome. From 2011 to 2013, a total of 36 patients with ruptured saccular intracranial aneurysm were recruited in our study. Before coil embolization, we draw blood samples at the orifice of a culprit aneurysm and in the remote peripheral vein for measurements of the CyPA levels...
September 2015: Medicine (Baltimore)
N Subhash, R Sriram, Gino A Kurian
Vascular bed calcification is a common feature of ends stage renal disease that may lead to a complication in cardiovascular and cerebrovascular beds, which is a promoting cause of myocardial infarction, stroke, dementia and aneurysms. Sodium thiosulfate (STS) due to its multiple properties such as antioxidant and calcium chelation has been reported to prevent vascular calcification in uremic rats, without mentioning its impact on cerebral function. Moreover, the previous studies have not explored the effect of STS on the mitochondrial dysfunction, one of the main pathophysiological features associated with the disease and the main site for STS metabolism...
November 2015: Neurochemistry International
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