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Brain-based interventions

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https://www.readbyqxmd.com/read/28933607/a-randomised-controlled-trial-of-a-web-based-multi-modal-therapy-program-to-improve-executive-functioning-in-children-and-adolescents-with-acquired-brain-injury
#1
Adina Piovesana, Stephanie Ross, Owen Lloyd, Koa Whittingham, Jenny Ziviani, Robert S Ware, Lynne McKinlay, Roslyn N Boyd
OBJECTIVE: To examine the efficacy of a multi-modal web-based therapy program, Move it to improve it (Mitii™) delivered at home to improve Executive Functioning (EF) in children with an acquired brain injury (ABI). DESIGN: Randomised Waitlist controlled trial. SETTING: Home environment. PARTICIPANTS: Sixty children with an ABI were matched in pairs by age and intelligence quotient then randomised to either 20-weeks of Mitii™ training or 20 weeks of Care As Usual (waitlist control; n=30; 17 males; mean age=11y, 11m (±2y, 6m); Full Scale IQ=76...
October 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28933211/traumatic-brain-injury-current-treatment-strategies-and-future-endeavors
#2
Michael Galgano, Gentian Toshkezi, Xuecheng Qiu, Thomas Russell, Lawrence Chin, Li-Ru Zhao
Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of consciousness to an unrelenting comatose state and death. In the most severe form of TBI, the entirety of the brain is affected by a diffuse type of injury and swelling. Treatment modalities vary extensively based on the severity of the injury and range from daily cognitive therapy sessions to radical surgery such as bilateral decompressive craniectomies. Guidelines have been set forth regarding the optimal management of TBI, but they must be taken in context of the situation and cannot be used in every individual circumstance...
July 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28932982/cerebral-fat-embolism-recognition-complications-and-prognosis
#3
Daniel Agustín Godoy, Mario Di Napoli, Alejandro A Rabinstein
Fat embolism syndrome (FES) is a rare syndrome caused by embolization of fat particles into multiple organs including the brain. It typically manifests with petechial rash, deteriorating mental status, and progressive respiratory insufficiency, usually occurring within 24-48 h of trauma with long-bone fractures or an orthopedic surgery. The diagnosis of FES is based on clinical and imaging findings, but requires exclusion of alternative diagnoses. Although there is no specific treatment for FES, prompt recognition is important because it can avoid unnecessary interventions and clarify prognosis...
September 20, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28931469/restorative-effects-of-curcumin-on-sleep-deprivation-induced-memory-impairments-and-structural-changes-of-the-hippocampus-in-a-rat-model
#4
Ali Noorafshan, Fatemeh Karimi, Ali-Mohammad Kamali, Saied Karbalay-Doust, Mohammad Nami
The present study examined the consequences of rapid eye-movement sleep-deprivation (REM-SD) with or without curcumin treatment. The outcome measures comprised quantitative features in the three-dimensional reconstructed (3DR) CA1 and dentate gyrus in experimental and control animals using stereological procedures. Male rats were arbitrarily assigned to nine groups based on the intervention and treatment administered including: 1-cage control+distilled water, 2-cage control+curcumin (100mg/kg/day), 3-cage control+olive oil, 4-REM-SD+distilled water, 5-REM-SD+curcumin, 6-REM-SD+olive oil, 7-grid-floor control+distilled water, 8-grid-floor control+curcumin, and 9-grid-floor control+olive oil...
September 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/28930568/medical-imaging-diagnosis-of-early-alzheimer-s-disease
#5
Fatma El-Zahraa A El-Gamal, Mohammed M Elmogy, Mohammed Ghazal, Ahmed Atwan, Manual F Casanova, Gregory N Barnes, Ayman El-Baz, Hassan Hajjdiab
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases that influences the central nervous system, often leading to dire consequences for quality of life. The disease goes through some stages mainly divided into early, moderate, and severe. Among them, the early stage is the most important as medical intervention has the potential to alter the natural progression of the condition. In practice, the early diagnosis is a challenge since the neurodegenerative changes can precede the onset of clinical symptoms by 10-15 years...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28928649/changes-in-electroencephalography-complexity-using-a-brain-computer-interface-motor-observation-training-in-chronic-stroke-patients-a-fuzzy-approximate-entropy-analysis
#6
Rui Sun, Wan-Wa Wong, Jing Wang, Raymond Kai-Yu Tong
Entropy-based algorithms have been suggested as robust estimators of electroencephalography (EEG) predictability or regularity. This study aimed to examine possible disturbances in EEG complexity as a means to elucidate the pathophysiological mechanisms in chronic stroke, before and after a brain computer interface (BCI)-motor observation intervention. Eleven chronic stroke subjects and nine unimpaired subjects were recruited to examine the differences in their EEG complexity. The BCI-motor observation intervention was designed to promote functional recovery of the hand in stroke subjects...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28928644/near-infrared-spectroscopy-based-frontal-lobe-neurofeedback-integrated-in-virtual-reality-modulates-brain-and-behavior-in-highly-impulsive-adults
#7
Justin Hudak, Friederike Blume, Thomas Dresler, Florian B Haeussinger, Tobias J Renner, Andreas J Fallgatter, Caterina Gawrilow, Ann-Christine Ehlis
Based on neurofeedback (NF) training as a neurocognitive treatment in attention-deficit/hyperactivity disorder (ADHD), we designed a randomized, controlled functional near-infrared spectroscopy (fNIRS) NF intervention embedded in an immersive virtual reality classroom in which participants learned to control overhead lighting with their dorsolateral prefrontal brain activation. We tested the efficacy of the intervention on healthy adults displaying high impulsivity as a sub-clinical population sharing common features with ADHD...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28928634/transcranial-alternating-current-stimulation-tacs-mechanisms-and-protocols
#8
REVIEW
Amir V Tavakoli, Kyongsik Yun
Perception, cognition and consciousness can be modulated as a function of oscillating neural activity, while ongoing neuronal dynamics are influenced by synaptic activity and membrane potential. Consequently, transcranial alternating current stimulation (tACS) may be used for neurological intervention. The advantageous features of tACS include the biphasic and sinusoidal tACS currents, the ability to entrain large neuronal populations, and subtle control over somatic effects. Through neuromodulation of phasic, neural activity, tACS is a powerful tool to investigate the neural correlates of cognition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28928195/reach-study-protocol-of-a-randomised-trial-of-rehabilitation-very-early-in-congenital-hemiplegia
#9
Roslyn N Boyd, Jenny Ziviani, Leanne Sakzewski, Iona Novak, Nadia Badawi, Kerstin Pannek, Catherine Elliott, Susan Greaves, Andrea Guzzetta, Koa Whittingham, Jane Valentine, Cathy Morgan, Margaret Wallen, Ann-Christin Eliasson, Lisa Findlay, Robert Ware, Simona Fiori, Stephen Rose
OBJECTIVES: Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28928027/development-of-a-sexual-needs-rehabilitation-framework-in-women-post-spinal-cord-injury-a-study-from-iran
#10
Raziyeh Maasoumi, Fatemeh Zarei, Effat Merghati-Khoei, Taylor Lawson, Seyyed Hasan Emami-Razavi
OBJECTIVE: To develop a sexual needs rehabilitation framework in women post spinal cord injury (SCI) DESIGN: Mixed-methods study SETTING: Brain and Spinal Cord Injury Research Center (BASIR), Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran PARTICIPANTS: Married women with at least one year passed injury INTERVENTION: Not applicable METHODS: This study was designed in three steps; primary needs assessment with quantitative and qualitative methods, prioritizing identified needs by expert panels, and developing framework...
September 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28928025/development-implementation-and-use-of-a-process-to-promote-knowledge-translation-in-rehabilitation
#11
Jennifer L Moore, Julia Carpenter, Anne Marie Doyle, Laura Doyle, Piper Hansen, Bridget Hahn, T George Hornby, Heidi R Roth, Susan Spoeri, Rachel Tappan, Krista Van Der Laan
OBJECTIVE: To examine the use and impact of the BRAIN on evidence-based practice (EBP) over 6 years. DESIGN: A successive independent samples study. SETTING: A large rehabilitation system. PARTICIPANTS: Successive samples of allied health clinicians in 2009 (n=136), 2012 (n=115), and 2015 (n=121). INTERVENTIONS: The BRAIN includes two components: 1) a process to synthesize, adapt and make recommendations about the application of evidence; and 2) a process to implement the recommended practices in 3 levels of care...
September 16, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28925881/coping-with-stress-during-aging-the-importance-of-a-resilient-brain
#12
P Sampedro-Piquero, P Álvarez-Suárez, A Begega
BACKGROUND: Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging. METHODS: In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response...
September 15, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28923933/longitudinal-identification-of-clinically-distinct-neurophenotypes-in-young-children-with-fragile-x-syndrome
#13
Jennifer L Bruno, David Romano, Paul Mazaika, Amy A Lightbody, Heather Cody Hazlett, Joseph Piven, Allan L Reiss
Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability. The cognitive, behavioral, and neurological phenotypes observed in affected individuals can vary considerably, making it difficult to predict outcomes and determine the need for interventions. We sought to examine early structural brain growth as a potential marker for identification of clinically meaningful subgroups. Participants included 42 very young boys with FXS who completed a T1-weighted anatomical MRI and cognitive/behavioral assessment at two longitudinal time points, with mean ages of 2...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923160/applying-the-neurodynamics-of-emotional-circular-causalities-in-psychosocial-and-cognitive-therapy-using-multi-sensory-environments-an-orbde-case-study-analysis
#14
Janice Ryan
This exploratory, evidence-based practice research study focuses on presenting a plausible mesoscopic brain dynamics hypothesis for the benefits of treating clients with psychosocial and cognitive challenges using a mindful therapeutic approach and multi-sensory environments. After an extensive neuroscientific review of the therapeutic benefits of mindfulness, a multi-sensory environment is presented as a window of therapeutic opportunity to more quickly and efficiently facilitate the neurobiological experience of becoming more mindful or conscious of self and environment...
October 2017: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/28922350/stem-cells-and-cell-based-therapies-for-cerebral-palsy-a-call-for-rigor
#15
REVIEW
Lauren L Jantzie, Joseph Scafidi, Shenandoah Robinson
Cell-based therapies hold significant promise for infants at risk for cerebral palsy (CP) from perinatal brain injury (PBI). PBI leading to CP results from multi-faceted damage to neural cells. Complex developing neural networks are injured by neural cell damage plus unique perturbations in cell signaling. Given that cell-based therapies can simultaneously repair multiple injured neural components during critical neurodevelopmental windows, these interventions potentially offer efficacy for patients with CP...
September 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28922174/evaluating-the-effectiveness-of-facebook-to-impact-the-knowledge-of-evidence-based-employment-practices-by-individuals-with-traumatic-brain-injury-a-knowledge-translation-random-control-study
#16
Katherine J Inge, Carolyn W Graham, James W McLaughlin, Doug Erickson, Paul Wehman, Hannah E Seward
BACKGROUND: Individuals with traumatic brain injury (TBI) experience difficulty with obtaining and maintaining employment post-injury. Although vocational rehabilitation (VR) can be one option to provide individuals with TBI support and services to lead to successful employment outcomes, information about these services can be difficult and confusing to navigate. Providing information on evidence-based employment practices to individuals with TBI through social media could be an effective approach...
September 14, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28918120/moment-by-moment-in-women-s-recovery-randomized-controlled-trial-protocol-to-test-the-efficacy-of-a-mindfulness-based-intervention-on-treatment-retention-and-relapse-prevention-among-women-in-residential-treatment-for-substance-use-disorder
#17
Hortensia Amaro, David S Black
Although therapeutic treatments exist for substance use disorder (SUD), about half of individuals who enter treatment leave early and relapse to substance use. Early dropout from residential treatment places individuals at risk of relapse, and women in SUD residential treatment represent a vulnerable population. Evidence gaps persist for the use of mindfulness-based interventions (MBIs) among racially and ethnically diverse women with SUDs, especially regarding the efficacy of MBIs adapted to prevent residential dropout and relapse...
September 13, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28917669/knowledge-driven-computational-modeling-in-alzheimer-s-research-current-state-and-future-trends
#18
Hugo Geerts, Martin Hofmann-Apitius, Thomas J Anastasio
Neurodegenerative diseases such as Alzheimer's disease (AD) follow a slowly progressing dysfunctional trajectory, with a large presymptomatic component and many comorbidities. Using preclinical models and large-scale omics studies ranging from genetics to imaging, a large number of processes that might be involved in AD pathology at different stages and levels have been identified. The sheer number of putative hypotheses makes it almost impossible to estimate their contribution to the clinical outcome and to develop a comprehensive view on the pathological processes driving the clinical phenotype...
September 14, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28916269/the-sterile-controversy-on-the-amyloid-cascade-hypothesis
#19
Marco Canevelli, Giuseppe Bruno, Matteo Cesari
In these last years, several phase III randomized controlled trials testing promising candidates sharing Aβ depots as target of their action have failed, despite showing some reductions of the brain Aβ charge. The announcements of the negative results have heated the discussion in the field and divided the scientific community between the defenders versus the opponents of the Aβ theory. In the present article, we discuss the limits of these drastic, opposite positions and we propose a novel approach to Alzheimer's disease (AD)...
September 12, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28914724/the-role-of-brain-structure-in-predicting-adherence-to-a-physical-activity-regimen
#20
Swathi Gujral, Edward McAuley, Lauren E Oberlin, Arthur F Kramer, Kirk I Erickson
OBJECTIVE: Physical activity is important for maintaining health throughout the lifespan. However, adherence to PA regimens is poor with approximately 50% of older adults terminating activity intervention programs within 6 months. In this study we tested whether gray matter volume and white matter microstructural integrity prior to the initiation of a PA intervention predicts PA adherence. METHODS: 159 adults aged 60-80 years were randomly assigned to a moderate-intensity aerobic walking condition or a non-aerobic stretching and toning condition...
September 13, 2017: Psychosomatic Medicine
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