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https://www.readbyqxmd.com/read/29330632/inate-immunity-in-rosacea-langerhans-cells-plasmacytoid-dentritic-cells-toll-like-receptors-and-inducible-oxide-nitric-synthase-inos-expression-in-skin-specimens-case-control-study
#1
Ana Karina Alves Moura, Fernanda Guedes, Maria Cecília Rivitti-Machado, Mirian N Sotto
Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Recent studies have suggested that aberrant innate immunity is central to this disease. The aim of this study was to examine the presence of Langerhans cells, plasmacytoid dentritic cells (PDC), the expression of Toll-like receptors (TLR) and inducible oxide nitric synthase (iNOS) in skin of patients with rosacea, to highlight the participation of innate immunity in its pathogenesis...
January 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29327713/expression-of-enhancer-of-zeste-homolog-2-ezh2-protein-in-histiocytic-and-dendritic-cell-neoplasms-with-evidence-for-p-erk1-2-related-but-not-myc-or-p-stat3-related-cell-signaling
#2
Xuejun Tian, Jie Xu, Christopher Fletcher, Jason L Hornick, David M Dorfman
EZH2 is an important enzymatic subunit of the epigenetic regulator polycomb repressive complex 2 (PRC2), which controls gene silencing through post-translational modification, and is overexpressed in various carcinomas and hematopoietic neoplasms. We found that the majority of cases of histiocytic and dendritic cell neoplasms, including histiocytic sarcoma, follicular dendritic cell sarcoma, Langerhans cell histiocytosis, and interdigitating dendritic cell sarcoma, show strong EZH2 expression by immunohistochemical staining, in contrast to benign histiocytic lesions and normal cellular counterparts, which did not show EZH2 expression, suggesting that this molecule may function as an oncogenic protein in these neoplasms...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29326339/ninety-year-old-man-with-hypereosinophilia-lymphadenopathies-and-pruritus
#3
José Guilherme Freitas, Ana Jorge, Daniel Rei, Joana Graça
We report a case of a 90-year-old man with hypereosinophilia, lymphadenopathies and skin lesions, namely lichenification and pruritus. An aetiological investigation was performed, and a bone marrow (BM) biopsy and aspirate showed a hypercellular marrow with hypereosinophilia without dysmorphia or abnormal elements, and the BM and inguinal node's immunophenotyping denied any presence of abnormal lymphoid cell population. The inguinal node biopsy revealed a multinodular proliferation of large cells S100 and CD1a+, and a diagnosis of Langerhans cell histiocytosis was made...
January 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29319366/effects-of-subchronic-acrylamide-treatment-on-the-endocrine-pancreas-of-juvenile-male-wistar-rats
#4
M Stošić, M Matavulj, J Marković
Acrylamide (AA) is a well-known industrial monomer with carcinogenic, mutagenic, neurotoxic and endocrine disruptive effects on living organisms. AA has been the subject of renewed interest owing to its presence in various food products. We investigated the potential adverse effects of oral AA treatment on the endocrine pancreas of juvenile rats using histochemical, immunohistochemical, stereological and biochemical methods. Thirty juvenile male Wistar rats were divided into one control and two AA treatment groups: one treated with 25 mg/kg AA and the other treated with 50 mg/kg AA for 21 days...
January 10, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29318457/decreased-intracellular-granule-movement-and-glucagon-secretion-in-pancreatic-%C3%AE-cells-attached-to-superior-cervical-ganglion-neurites
#5
Kiyoto Watabe, Satoru Yokawa, Yoshikazu Inoh, Takahiro Suzuki, Tadahide Furuno
Autonomic neurons innervate pancreatic islets of Langerhans and participate in the maintenance of blood glucose concentrations by controlling hormone levels through attachment with islet cells. We previously found that stimulated superior cervical ganglia (SCG) could induce Ca2+ oscillation in α cells via neuropeptide substance P using an in vitro co-culture model. In this study, we studied the effect of SCG neurite adhesion on intracellular secretory granule movement and glucagon secretion in α cells stimulated by low glucose concentration...
January 9, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29317365/intraoperative-mri-guided-biopsy-in-the-diagnosis-of-suprasellar-langerhans-cell-histiocytosis
#6
Kate T Carroll, Bryson C Lochte, James Y Chen, Vivian S Snyder, Bob S Carter, Clark C Chen
Magnetic resonance imaging (MRI)-guided biopsy is an emerging diagnostic technique that holds great promise for otherwise difficult to access neuroanatomy. Here we describe MRI-guided biopsy of a suprasellar lesion located posterior and superior to the pituitary stalk. The approach was successfully implemented in a 38-year-old woman who had developed progressive visual deterioration. Intra-operative MRI revealed the need for trajectory adjustment due to an unintended, minor deviation in the burr hole entry point, demonstrating the benefit of an MRI-guided approach...
January 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29312770/development-of-pulmonary-langerhans-cell-histiocytosis-in-a-patient-with-established-adenocarcinoma-of-the-lung
#7
Or Kalchiem-Dekel, Adina Paulk, Seth J Kligerman, Allen P Burke, Nirav G Shah, Renee K Dixon
Newly-appearing lung nodules on surveillance imaging in patients with pre-existing lung cancer can present a diagnostic dilemma when attempting to differentiate between metastatic disease, infection, and other inflammatory conditions. Here we report a case of an EGFR-/ALK-/BRAF+ metastatic adenocarcinoma patient who underwent lung biopsy for evaluation of upper-lobe predominant lung nodules revealed to represent pulmonary Langerhans cell histiocytosis (PLCH). The patient was a heavy smoker and admitted to increase her smoking habit after initially learning about her diagnosis with lung cancer...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29301512/epithelial-changes-with-corneal-punctate-epitheliopathy-in-type-2-diabetes-mellitus-and-their-correlation-with-time-to-healing
#8
Jing-Hao Qu, Li Li, Lei Tian, Xiao-Yu Zhang, Ravi Thomas, Xu-Guang Sun
BACKGROUND: To study basal epithelial cell (BEC), sub-basal nerve plexus (SBN) and Langerhans cell (LC) density in patients with type 2 diabetes mellitus (T2DM) with corneal punctate epitheliopathy (CPE) and to assess their association with time to healing of CPE. METHODS: Retrospective study of in vivo confocal microscopy (IVCM) in 160 eyes from 160 patients with T2DM diagnosed with CPE due to a single cause. Key exclusion criteria included multiple-causes for CPE or treatment with autologous serum...
January 4, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29301140/autopsy-findings-in-a-case-of-pulmonary-langerhans-cell-histiocytosis-associated-pulmonary-hypertension
#9
Daisuke Taniyama, Hirofumi Kamata, Keisuke Miyamoto, Shuko Mashimo, Fumio Sakamaki
No abstract text is available yet for this article.
December 30, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29295520/the-origin-of-skin-dendritic-cell-network-and-its-role-in-psoriasis
#10
REVIEW
Tae-Gyun Kim, Sung Hee Kim, Min-Geol Lee
Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DCs usually denotes conventional DCs (cDCs). Skin contains a unique DC network mainly composed of embryo precursor-derived epidermal Langerhans cells (LCs) and bone marrow-derived dermal cDCs, which can be further classified into type 1 (cDC1) and type 2 (cDC2) subsets...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29290820/breaking-the-barrier-potent-anti-inflammatory-activity-following-efficient-topical-delivery-of-etanercept-using-thermoresponsive-nanogels
#11
M Giulbudagian, G Yealland, S Hönzke, A Edlich, B Geisendörfer, B Kleuser, S Hedtrich, M Calderón
Topical administration permits targeted, sustained delivery of therapeutics to human skin. Delivery to the skin, however, is typically limited to lipophilic molecules with molecular weight of < 500 Da, capable of crossing the stratum corneum. Nevertheless, there are indications protein delivery may be possible in barrier deficient skin, a condition found in several inflammatory skin diseases such as psoriasis, using novel nanocarrier systems. METHODS: Water in water thermo-nanoprecipitation; dynamic light scattering; zeta potential measurement; nanoparticle tracking analysis; atomic force microscopy; cryogenic transmission electron microscopy; UV absorption; centrifugal separation membranes; bicinchoninic acid assay; circular dichroism; TNFα binding ELISA; inflammatory skin equivalent construction; human skin biopsies; immunohistochemistry; fluorescence microscopy; western blot; monocyte derived Langerhans cells; ELISA Results: Here, we report the novel synthesis of thermoresponsive nanogels (tNG) and the stable encapsulation of the anti-TNFα fusion protein etanercept (ETR) (~150 kDa) without alteration to its structure, as well as temperature triggered release from the tNGs...
2018: Theranostics
https://www.readbyqxmd.com/read/29283208/microphysiological-analysis-platform-of-pancreatic-islet-%C3%AE-cell-spheroids
#12
Sang Hun Lee, SoonGweon Hong, Jihwan Song, Byungrae Cho, Esther J Han, Sravani Kondapavulur, Dongchoul Kim, Luke P Lee
The hallmarks of diabetics are insufficient secretion of insulin and dysregulation of glucagon. It is critical to understand release mechanisms of insulin, glucagon, and other hormones from the islets of Langerhans. In spite of remarkable advancements in diabetes research and practice, robust and reproducible models that can measure pancreatic β-cell function are lacking. Here, a microphysiological analysis platform (MAP) that allows the uniform 3D spheroid formation of pancreatic β-cell islets, large-scale morphological phenotyping, and gene expression mapping of chronic glycemia and lipidemia development is reported...
December 28, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29281781/erdheim-chester-disease-involving-lymph-nodes-and-liver-clinically-mimicking-lymphoma-a-case-report
#13
Yeoun Eun Sung, Yoon Seo Lee, Jieun Lee, Kyo Young Lee
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis and multisystem disease. First described in 1930, there are no more than 750 cases reported. The etiology remains unknown, but a majority of cases of ECD and Langerhans cell histiocytosis were found to have clonal mutations involving genes of the MAPK pathway. We recently encountered a 53-year-old male patient with extensive ECD involving the systemic lymph nodes, pleura, liver, and long bones clinically mimicking malignant lymphoma. Biopsies were performed at multiple sites, including a pleural mass, an external iliac lymph node, bone marrow, and the liver...
December 27, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29250688/pulmonary-langerhans-cell-histiocytosis-in-a-26-year-old-female-still-a-diagnostic-challenge
#14
Edith Simona Ianoşi, Mihaela Mureşan, Simona Gurzu, Eugenia Corina Budin, Ioan Jung, Tivadar Bara, Gabriela Jimborean
Langerhans cell histiocytosis (LCH) is a rare disorder caused by monoclonal Langerhans cells proliferation in bone, skin, lung, lymph nodes, liver, spleen, nervous or hematopoietic system. Pulmonary LCH is a diagnostic trap that is displayed on computed tomography (CT) as an interstitial disorder with honeycomb aspect. In this paper, we present an unusual case of a 26-year-old female that was hospitalized with progressive worsening dyspnea and history of recurrent pneumonia. Lung biopsy showed fibrosis of the interalveolar septa, architectural distortion and large cells with foamy cytoplasm and convoluted nuclei that were marked by CD68, S-100 and the specific antibody CD1a that allowed establishing the diagnosis of pulmonary LCH...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29246798/dlx3-dependent-stat3-signaling-in-keratinocytes-regulates-skin-immune-homeostasis
#15
Shreya Bhattacharya, Jin-Chul Kim, Youichi Ogawa, Gaku Nakato, Veronica Nagle, Stephen R Brooks, Mark C Udey, Maria I Morasso
Epidermal specific deletion of the homeobox transcription regulator DLX3 disrupts keratinocyte differentiation and results in an IL-17-linked psoriasis-like skin inflammation. To identify the epidermal initiating signals produced by DLX3-null keratinocytes, we performed acute deletion of DLX3 in adult epidermis using a tamoxifen-inducible Krt14-cre/ERT system. K14CreERT;DLX3fl/fl (icKO) skin exhibited dysregulated expression of differentiation-associated genes, upregulation of proinflammatory cytokines, and accumulation of Langerhans cells and macrophages within 3 days of tamoxifen-induced DLX3 ablation...
December 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29243280/mixed-histiocytosis-a-case-report-and-published-work-review
#16
Zhongtao Li, Yun Li, Weiping Liu, Jinfan Li, Lin Wang
Histiocytoses are a group of heterogeneous diseases that encompass Langerhans cell histiocytosis and non-Langerhans cell histiocytosis. Cutaneous plane xanthoma is a non-Langerhans cell histiocytic disorder characterized by the presence of yellow-orange plaques on the face, neck, upper trunk and extremities. It can appear in association with several systemic diseases (including dyslipidemias, paraproteinemias, cardiovascular diseases and lymphoproliferative disorders), but is rarely connected with Langerhans cell histiocytoses...
December 15, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29238463/protective-effect-of-metformin-on-toxicity-of-butyric-acid-and-arsenic-in-isolated-liver-mitochondria-and-langerhans-islets-in-male-mice-an-in-vitro-study
#17
Akram Ahangarpour, Leila Zeidooni, Mohsen Rezaei, Soheila Alboghobeish, Azin Samimi, Ali Akbar Oroojan
Objectives: Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitochondria were isolated by adopting different centrifugation methods and pancreatic islets isolated by a collagenase method...
December 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29238347/langerhans-cells-programmed-by-the-epidermis
#18
REVIEW
Kalum Clayton, Andres F Vallejo, James Davies, Sofia Sirvent, Marta E Polak
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances. In a normal physiological, "non-dangerous" situation, LCs coordinate a continuous state of immune tolerance, preventing unnecessary and harmful immune activation. Conversely, when they sense a danger signal, for example during infection or when the physical integrity of skin has been compromised as a result of a trauma, they instruct T lymphocytes of the adaptive immune system to mount efficient effector responses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29232485/retraction-imaging-characteristics-of-liver-langerhans-cell-histiocytosis-in-children-by-hui-liu-xueying-long-xiaoyi-wang-wenzheng-li-and-yigang-pei
#19
(no author information available yet)
The above article from Pediatrics International, published as an Accepted Article online on April 28, 2017 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn by agreement between the authors, the Journal Editor-in-Chief, Atsushi Manabe, and John Wiley & Sons Australia, Ltd, on behalf of the Japan Pediatric Society. The withdrawal has been agreed at the request of the authors who have identified some serious problems that need to be addressed and who have found that some important information is missing...
September 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29228722/prognostic-factors-for-histiocytic-and-dendritic-cell-neoplasms
#20
Joji Shimono, Hiroaki Miyoshi, Fumiko Arakawa, Kensaku Sato, Takuya Furuta, Reiji Muto, Eriko Yanagida, Yuya Sasaki, Daisuke Kurita, Keisuke Kawamoto, Koji Nagafuji, Koichi Ohshima
Histiocytic and dendritic cell neoplasms are rare and poorly studied. We report the clinical characteristics and prognostic factors in such cases in Japan. We investigated the clinical characteristics and survival in 87 adult patients with histiocytic and dendritic cell neoplasms. Fifty patients had histiocytic sarcoma, 12 had Langerhans cell histiocytosis, 11 had follicular dendritic cell sarcoma, 8 had Langerhans cell sarcoma, 6 had interdigitating cell sarcoma and 1 had indeterminate dendritic cell sarcoma...
November 17, 2017: Oncotarget
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