Zhucheng Lin, Xuan Luo, Jason R Wickman, Deepa Reddy, Richa Pande, Yuzhen Tian, Vivian Triana, Jingyun Lee, Cristina M Furdui, Desmond Pink, Ahmet Sacan, Seena K Ajit
Chronic pain is a significant public health issue. Current treatments have limited efficacy and significant side effects, warranting research on alternative strategies for pain management. One approach involves using small extracellular vesicles (sEVs) to transport beneficial biomolecular cargo to aid pain resolution. Exosomes are 30-150 nm sEVs that can carry RNAs, proteins, and lipid mediators to recipient cells via circulation. sEVs can be beneficial or harmful depending on their source and contents. To investigate the short and long-term effects of mouse serum-derived sEVs in pain modulation, sEVs from naive control or spared nerve injury (SNI) model donor mice were injected intrathecally into naive recipient mice...
February 18, 2024: bioRxiv