keyword
https://read.qxmd.com/read/38493063/efficacy-of-acupuncture-on-cancer-pain-a-systematic-review-and-meta-analysis
#1
REVIEW
Miguel Faria, Mónica Teixeira, Maria João Pinto, Paulo Sargento
BACKGROUND: Pain associated with cancer is one of the greatest causes of reduced quality of life in patients. Acupuncture is one of the treatments used to address this issue, with the great advantage of having little or no side effects, especially when compared with pharmacological pain-killers. OBJECTIVE: The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer pain. SEARCH STRATEGY: Six electronic databases (PubMed, EBSCO, Cochrane Library, Scielo, b-On and Scopus) were searched for relevant articles about pain relief in cancer patients from their beginning until 2022 using MeSH terms such as "acupuncture," "electroacupuncture," "ear acupuncture," "acupuncture analgesia," ''oncological pain," and "cancer pain...
March 6, 2024: Journal of Integrative Medicine
https://read.qxmd.com/read/38455750/narrative-review-in-learning-curve-and-pediatric-robotic-training-program
#2
REVIEW
Giuseppe Autorino, Mario Mendoza-Sagaon, Maria Grazia Scuderi
BACKGROUND AND OBJECTIVE: Studying learning curve (LC) for robotic procedures and developing an adequate training program are two fundamental steps to standardize robotic procedures. With this aim, we analyzed the literature to study the LCs of different robotic procedures and the availability of standardized training problems. METHODS: The PubMed database was searched in the period from January 1995 to September 2022. Articles presenting LC and potential training programs in the pediatric population were chosen...
February 29, 2024: Translational Pediatrics
https://read.qxmd.com/read/38405813/inflammatory-pain-resolution-by-mouse-serum-derived-small-extracellular-vesicles
#3
Zhucheng Lin, Xuan Luo, Jason R Wickman, Deepa Reddy, Richa Pande, Yuzhen Tian, Vivian Triana, Jingyun Lee, Cristina M Furdui, Desmond Pink, Ahmet Sacan, Seena K Ajit
Chronic pain is a significant public health issue. Current treatments have limited efficacy and significant side effects, warranting research on alternative strategies for pain management. One approach involves using small extracellular vesicles (sEVs) to transport beneficial biomolecular cargo to aid pain resolution. Exosomes are 30-150 nm sEVs that can carry RNAs, proteins, and lipid mediators to recipient cells via circulation. sEVs can be beneficial or harmful depending on their source and contents. To investigate the short and long-term effects of mouse serum-derived sEVs in pain modulation, sEVs from naive control or spared nerve injury (SNI) model donor mice were injected intrathecally into naive recipient mice...
February 18, 2024: bioRxiv
https://read.qxmd.com/read/38391355/primary-extranodal-nk-t-cell-lymphoma-of-stomach-a-case-report-and-review-of-literature
#4
JOURNAL ARTICLE
Prashant Mane, Prashant Ramteke, Anand Singh, Ajay Gogia, Saumyaranjan Mallick
Extranodal Natural killer/T (NK/T) cell lymphoma nasal type is an aggressive non-Hodgkin lymphoma and has a constant association with Epstein-Barr virus (EBV) infection. Approximately more than 75% cases are located in upper aero-digestive tract, of which stomach is a very rare site. Very few cases of gastric extranodal NK/T cell lymphoma have been reported in the literature. A 22-year-old male patient presented with complaints of abdominal pain and hematemesis. Endoscopy showed a large ulcer in the stomach...
July 10, 2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38390792/genetic-guided-pharmacotherapy-for-coronary-artery-disease-a-systematic-and-critical-review-of-economic-evaluations
#5
JOURNAL ARTICLE
Ka Keat Lim, Rositsa Koleva-Kolarova, Hanin Farhana Kamaruzaman, Ahmad Amir Kamil, Phil Chowienczyk, Charles D A Wolfe, Julia Fox-Rushby
BACKGROUND: Genetic-guided pharmacotherapy (PGx) is not recommended in clinical guidelines for coronary artery disease (CAD). We aimed to examine the extent and quality of evidence from economic evaluations of PGx in CAD and to identify variables influential in changing conclusions on cost-effectiveness. METHODS AND RESULTS: From systematic searches across 6 databases, 2 independent reviewers screened, included, and rated the methodological quality of economic evaluations of PGx testing to guide pharmacotherapy for patients with CAD...
February 23, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38381030/periostial-and-cartilage-morphology-in-knee-osteoarthritis-beneficial-effects-of-supplementation-with-pycnogenol%C3%A2-centellicum%C3%A2
#6
JOURNAL ARTICLE
Gianni Belcaro, Maria R Cesarone, Claudia Scipione, Valeria Scipione, Morio Hosoi, Shu Hu, Andrea Ledda, Beatrice Feragalli, Roberto Cotellese, David Cox
BACKGROUND: The aim of this registry study was to evaluate the progress of osteoarthrosis (OA) symptoms after the intake of a new standardized supplement combination (Pycnogenol® + Centellicum® , both Horphag Research) in a group of subjects with OA. METHODS: Supplemented subjects took daily 150 mg Pycnogenol® + 450 mg Centellicum® for 6 months. Another comparable group of subjects using only standard management (SM) was included as a reference...
February 2024: Minerva surgery
https://read.qxmd.com/read/38376724/initial-diagnosis-of-extranodal-nk-t-cell-lymphoma-in-pericardial-fluid-with-concomitant-hemophagocytic-lymphohistiocytosis-hlh
#7
JOURNAL ARTICLE
Amani Khasawneh, Georgeann McGuinness, Nicholas Ward
Extranasal natural killer/T-cell lymphoma arising in the heart is rare and typically presents with non-specific clinical symptoms, necessitating a biopsy for a definitive diagnosis. We report an unusual case of a 48-year-old male who initially presented with chest pain and shortness of breath. Subsequent diagnosis via pericardial fluid analysis, including flow cytometry and immunohistochemical stains, revealed extranasal NK/T-cell lymphoma without sinonasal involvement. The analysis identified neoplastic lymphoid cells expressing CD2, cytoplasmic CD3, Epstein-Barr virus, and CD56 and exhibiting increased Ki-67 staining...
March 2024: Journal of Hematopathology
https://read.qxmd.com/read/38352627/extrapulmonary-tuberculosis-leading-to-abdominal-wall-mass-in-young-patient
#8
Mohadeseh Karimi, Ali AtashAbParvar
BACKGROUND: Tuberculosis is a bacterial infection that is caused by Mycobacterium tuberculosis . Tuberculosis has arguably been the largest killer of humans historically, and it remains one of the most important infectious causes of death in the world. Tuberculosis can be classified into different forms and it manifests as pulmonary and out pulmonary, respectively, in 85% and 15% of cases. Only a few cases of tuberculosis with abdominal wall involvement have been reported. Case Presentation ...
2024: Case Reports in Infectious Diseases
https://read.qxmd.com/read/38339399/targeting-trpv1-for-cancer-pain-relief-can-it-work
#9
REVIEW
Arpad Szallasi
Chronic intractable pain affects a large proportion of cancer patients, especially those with metastatic bone disease. Blocking sensory afferents for cancer pain relief represents an attractive alternative to opioids and other drugs acting in the CNS in that sensory nerve blockers are not addictive and do not affect the mental state of the patient. A distinct subpopulation of sensory afferents expresses the capsaicin receptor TRPV1. Intrathecal resiniferatoxin, an ultrapotent capsaicin analog, ablates TRPV1-expressing nerve endings exposed to the cerebrospinal fluid, resulting in permanent analgesia in women with cervical cancer metastasis to the pelvic bone...
February 2, 2024: Cancers
https://read.qxmd.com/read/38324818/maternal-and-paternal-licit-and-illicit-drug-use-smoking-and-drinking-and-autism-spectrum-disorder
#10
JOURNAL ARTICLE
Amanda de Andrade Costa, Maria Tereza Carvalho Almeida, Fernanda Alves Maia, Luiz Fernando de Rezende, Vanessa Souza de Araújo Saeger, Steffany Lara Nunes Oliveira, Gabriel Lopes Mangabeira, Marise Fagundes Silveira
The aim of this study was to investigate the association between maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder (ASD). We conducted a case-control study with children and adolescents diagnosed with ASD and neurotypical individuals. The data were collected using a semi-structured questionnaire administered during interviews with the children's mothers or guardians. The following variables were analyzed: child sex and age; maternal and parental age; use of medicines before and during pregnancy; classes of medicines used during pregnancy; maternal and paternal smoking; maternal and paternal drinking; maternal and paternal illicit drug use...
February 2024: Ciência & Saúde Coletiva
https://read.qxmd.com/read/38318599/a-rare-case-of-tuberculosis-revealed-by-acute-appendicitis-a-case-report
#11
Fouad Haddad, Malak Afifi, Fatima Zahra El Rhaoussi, Mohamed Tahiri, Wafaa Hliwa, Ahmed Bellabah, Sanaa Hachimi, Nisrine Bennani Guebessi, Badre Wafaa
According to the World Health Organization (WHO), tuberculosis (TB) is the 13th cause of death worldwide and the second infectious killer after HIV. It is an endemic disease in Morocco. Isolated appendicular TB is an uncommon form of extrapulmonary TB. We report a case of a 26-year-old woman admitted for acute abdominal pain in the right iliac fossa with fever, vomiting, and diarrhea. Physical examination and abdominal ultrasound confirmed appendicitis. Surgery was performed and revealed on histopathological examination of the resected appendix the diagnosis of tubercular appendicitis...
January 2024: Curēus
https://read.qxmd.com/read/38318132/j-2156-a-small-molecule-somatostatin-type-4-receptor-agonist-alleviated-hindpaw-hypersensitivity-in-the-streptozotocin-induced-rat-model-of-painful-diabetic-neuropathy-but-with-a-2-fold-decrease-in-potency-at-an-advanced-stage-in-the-model-mimicking-morphine
#12
JOURNAL ARTICLE
A Kuo, M Z Imam, R Li, L Lin, A Raboczyj, A E Bohmer, J R Nicholson, L Corradini, M T Smith
There is a large unmet need for novel pain-killers to improve relief of painful diabetic neuropathy (PDN). Herein, we assessed the efficacy of the somatostatin type 4 (SST4 ) receptor agonist, J-2156, for relief of PDN in rats. Diabetes was induced with streptozotocin (STZ; 70 mg/kg) and bilateral hindpaw hypersensitivity was fully developed by 8-week post-STZ. In the intervals, 8-12-weeks (morphine-sensitive phase; Phase 1) and 16-18-weeks (morphine-hyposensitive phase; Phase 2) post-STZ, rats received a single dose of intraperitoneal (i...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38282610/downregulation-of-pattern-recognition-receptors-on-macrophages-involved-in-aggravation-of-endometriosis
#13
JOURNAL ARTICLE
Tatsunori Shiraishi, Mariko Ikeda, Takami Watanabe, Yasuyuki Negishi, Go Ichikawa, Hanako Kaseki, Shigeo Akira, Rimpei Morita, Shunji Suzuki
PROBLEM: In women of reproductive age, endometriosis may contribute to dysmenorrhea, chronic pelvic pain, dyspareunia, infertility, adenomyosis, and endometrial ovarian cyst (EOC). Recent studies have shown that chronic inflammation occurs in the pelvis of endometriosis patients and that this inflammation is exacerbated by immunosuppression, leading to survival endometrial debris. However, the detailed immunological mechanisms underlying the aggravation of inflammation and immunosuppression in endometriosis patients remain unclear...
January 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38219166/comparison-of-intravenous-ibuprofen-and-paracetamol-for-peri-operative-analgesia-in-paediatric-day-care-tonsillectomy
#14
JOURNAL ARTICLE
Amna Zaheer, Kaukab Majeed, Asjad Sharif, Saima Bashir, Adeela Khan, Azhar Niwaz
OBJECTIVE: To determine the effectiveness of intravenous ibuprofen and acetaminophen as perioperative analgesics in paediatric patients undergoing day- care tonsillectomy with general anaesthesia. METHODS: The quasi-experimental stud y was conduc ted at the Ana esthe sia D epartment of Pa k Emirates M ilitary Hospital, Rawalpindi , Pak ist an, from July 20 21 to June 2022, and comp rised paediatric pa t ients aged 5-12 yea r s undergoing day- care tonsil lec tomy with gen era l anaesthesia...
January 2024: JPMA. the Journal of the Pakistan Medical Association
https://read.qxmd.com/read/38191169/combined-anesthesia-of-acupuncture-pharmacotherapy-in-pulmonary-resection-surgery-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Linxi Sun, Xuqiang Wei, Ke Wang, Zi Ye, Jia Zhou
OBJECTIVES: To evaluate the clinical value and safety of combined anesthesia of acupuncture-pharmacotherapy in pulmonary resection surgery. METHODS: The randomized controlled trials (RCTs) related to combined anesthesia of acupuncture-pharmacotherapy in pulmonary resection surgery were searched in PubMed, EMbase, Cochrane Library, Web of Science, SinoMed, CNKI, VIP database, Wanfang database, ClinicalTrials.gov, and the Chinese Clinical Trial Registry (https://www...
January 12, 2023: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://read.qxmd.com/read/38144564/estrobolome-dysregulation-is-associated-with-altered-immunometabolism-in-a-mouse-model-of-endometriosis
#16
JOURNAL ARTICLE
Hasan Alghetaa, Amira Mohammed, Narendra P Singh, Ryan F Bloomquist, Ioulia Chatzistamou, Mitzi Nagarkatti, Prakash Nagarkatti
INTRODUCTION: Endometriosis is a painful disease that affects around 5% of women of reproductive age. In endometriosis, ectopic endometrial cells or seeded endometrial debris grow in abnormal locations including the peritoneal cavity. Common manifestations of endometriosis include dyspareunia, dysmenorrhea, chronic pelvic pain and often infertility and symptomatic relief or surgical removal are mainstays of treatment. Endometriosis both promotes and responds to estrogen imbalance, leading to intestinal bacterial estrobolome dysregulation and a subsequent induction of inflammation...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38104670/scorpion-sting-in-hafizabad-pakistan-facility-based-epidemiological-study
#17
JOURNAL ARTICLE
Muhammad Mohsin Ahsan, Zoya Gulzar, Hafiz Muhammad Tahir, Aamir Ali, Muhammad Ismail, Muhammad Khalid Mukhtar, Zain Ul Abdin
Scorpion envenomation is a widespread issue in tropical and subtropical countries. In the present study epidemiology of scorpion sting cases and potential treatment options in district Hafizabad, Pakistan are documented. Hafizabad city and the adjacent villages were selected for the data collection. Age, gender, time, site of scorpion sting on the body, scorpion sting symptoms, number of patients obtaining medical attention and the number of fatalities (if any) were noted. Data showed that scorpion envenomation often occurs in people between the ages of 16-47 years...
December 15, 2023: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38045655/the-effect-of-various-combinations-of-peripheral-nerve-blocks-on-postoperative-pain-in-laparoscopic-cholecystectomy-a-comparative-prospective-study
#18
JOURNAL ARTICLE
Zoya Haitov Ben Zikri, Maryna Volis, Andrei Mazur, Tatjana Orlova, Hana Alon, Sara Bar Yehuda, Vladislav Gofman
OBJECTIVES: Most patients who undergo laparoscopic cholecystectomy (LC) experience moderate to severe pain in the first 24 hours after surgery. The transversus abdominal plane (TAP) is currently used for post-LC analgesia. Posterior, subcostal, or rectus sheath TAP blocks are the conventional approaches used. The aim of the current study was to compare the efficacy of combinations of various peripheral blocks on pain intensity and the use of pain killers, shortly after LC. METHODS: This was a prospective, double-blind study, in which 200 patients who were about to undergo a LC procedure were recruited and randomized into 4 groups: patients receiving one of the following: TAP block alone, subcostal Tap block alone, subcostal TAP block with a TAP block, or subcostal TAP with a rectus sheath block...
2023: International Journal of Clinical Practice
https://read.qxmd.com/read/38024045/predict2protect-machine-learning-web-application-in-early-detection-of-heart-disease
#19
JOURNAL ARTICLE
Ankita Mandal, Soma Pradhan
Across the world, there are few universal scenarios, but the pain of losing a loved one to heart disease is an exception and a reality shared by millions every year. Heart disease is the greatest killer in society today, and one prevalent root of this issue is untimely diagnosis, often caused by unsustainable costs and lack of accessible healthcare for underserved populations. Recognizing these disparities, the goal of this project was to create an easily available application and interface for all that accurately indicates one's risk of heart disease...
November 2023: Curēus
https://read.qxmd.com/read/38018513/diagnostic-biomarker-for-type-2-diabetic-peripheral-neuropathy-via-comprehensive-bioinformatics-analysis
#20
JOURNAL ARTICLE
Xiaoyu Chen, Qingquan Liu, Niyao Chen, Jiangxin Ma, Xiaohong Wu, Haibin Zhang, Liying Yu, Huibin Huang
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes mellitus (T2DM), which frequently results in disabling neuropathic pain and lower-limb amputation. The identification of noninvasive biomarkers for DPN may help early detection and individualized treatment of DPN. METHODS: In this study, we identified differentially expressed genes (DEGs) between DPN and the control based on blood-source (GSE95849) and tissue-source gene expression profiles (GSE143979) from the Gene Expression Omnibus (GEO) database using limma, edgeR, and DESeq2 approaches...
November 29, 2023: Journal of Diabetes
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