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Electophysiology

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https://www.readbyqxmd.com/read/25441713/viruses-infecting-marine-picoplancton-encode-functional-potassium-ion-channels
#1
Fenja Siotto, Corinna Martin, Oliver Rauh, James L Van Etten, Indra Schroeder, Anna Moroni, Gerhard Thiel
Phycodnaviruses are dsDNA viruses, which infect algae. Their large genomes encode many gene products, like small K(+) channels, with homologs in prokaryotes and eukaryotes. Screening for K(+) channels revealed their abundance in viruses from fresh-water habitats. Recent sequencing of viruses from marine algae or from salt water in Antarctica revealed sequences with the predicted characteristics of K(+) channels but with some unexpected features. Two genes encode either 78 or 79 amino acid proteins, which are the smallest known K(+) channels...
October 2014: Virology
https://www.readbyqxmd.com/read/25247680/the-role-of-resting-state-networks-in-focal-neocortical-seizures
#2
S Kathleen Bandt, David T Bundy, Ammar H Hawasli, Kareem W Ayoub, Mohit Sharma, Carl D Hacker, Mrinal Pahwa, Eric C Leuthardt
OBJECTIVE: The role of resting state functional networks in epilepsy is incompletely understood. While some pathologic diagnoses have been shown to have maintained but altered resting state connectivity, others have implicated resting state connectivity in disease progression. However little is known about how these resting state networks influence the behavior of a focal neocortical seizure. METHODS: Using data taken from invasively monitored patients with intractable focal neocortical epilepsy, we evaluated network connectivity (as determined by oscillatory covariance of the slow cortical potential (<0...
2014: PloS One
https://www.readbyqxmd.com/read/24825042/laminoplasty-is-better-of-laminectomy-in-cervical-stenotic-myelopathy-myth-or-truth
#3
COMPARATIVE STUDY
G M Della Pepa, R Roselli, G La Rocca, A Spallone, G Barbagallo, M Visocchi
INTRODUCTION: Laminoplasty has been proposed as a treatment for cervical stenotic myelopathy (CSM) as an alternative to standard laminectomy as this has been considered directly associated with an increased risk of postoperative deformity. METHODS: We retrospective reviewed postoperative results of open door laminoplasty (unilateral approach technique) compared with laminectomy in terms of clinical/electophysiological results (somatosensory evoked potentials - SSEP, and motor evoked potentials - MEP); in addition the rate of subsequent spinal deformities was analyzed in both techniques...
2014: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/20923394/methomyl-alphamethrin-poisoning-presented-with-cholinergic-crisis-cortical-blindness-and-delayed-peripheral-neuropathy
#4
Yu-Hui Hu, Chen-Chang Yang, Juo-Fang Deng, Ming-Ling Wu
OBJECTIVE: Methomyl-alphamethrin is a mixture of carbamate and pyrethroid insecticides. Carbamate insecticides function as reversible cholinesterase inhibitors, which may produce life-threatening cholinergic syndrome. Cortical blindness and delayed neuropathy were rarely reported complications of carbamate insecticide exposures. Here we reported a case of intentional methomyl-alphamethrin ingestion. CASE REPORT: A 41-year-old woman attempted suicide by drinking 200 mL of methomyl-alphamethrin insecticide and soon presented with unconsciousness, hypothermia, and shock...
October 2010: Clinical Toxicology
https://www.readbyqxmd.com/read/19086429/-case-of-painful-muscle-spasm-induced-by-thoracic-vertebral-fracture-successful-treatment-with-lumbar-sympathetic-ganglia-block
#5
Fumitaka Shimizu, Motoharu Kawai, Michiaki Koga, Jun-ichi Ogasawara, Kiyoshi Negoro, Takashi Kanda
We report a 70-year-old man, who developed painful involuntary muscle contraction of the left leg after the lumbar discectomy, which exacerbated after a vertebral fracture of Th12. This involuntary movement was accompanied with the abnormal position of left leg simulating triple flexion response, and was induced by active or passive movement of his left knee and foot joints. Several drugs including benzodiazepines and dantrolene were ineffective, although treatment with baclofen or carbamazepine was effective...
October 2008: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/18671867/cutaneous-nociception-evoked-by-15-delta-pgj2-via-activation-of-ion-channel-trpa1
#6
COMPARATIVE STUDY
Lillian Cruz-Orengo, Ajay Dhaka, Robert J Heuermann, Timothy J Young, Michael C Montana, Eric J Cavanaugh, Donghee Kim, Gina M Story
BACKGROUND: A number of prostaglandins (PGs) sensitize dorsal root ganglion (DRG) neurons and contribute to inflammatory hyperalgesia by signaling through specific G protein-coupled receptors (GPCRs). One mechanism whereby PGs sensitize these neurons is through modulation of "thermoTRPs," a subset of ion channels activated by temperature belonging to the Transient Receptor Potential ion channel superfamily. Acrid, electrophilic chemicals including cinnamaldehyde (CA) and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues...
2008: Molecular Pain
https://www.readbyqxmd.com/read/18087236/-chronic-inflammatory-demyelinating-polyneuropathies-problem-of-the-long-term-therapeutic-management
#7
REVIEW
J-P Camdessanché
INTRODUCTION: No guideline is available for the long-term therapeutic management of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). STATE OF THE ART: Efficacy of corticosteroids, intravenous immunoglobulins and plasma exchanges has been shown in trials conducted on short periods. Only experts'recommendations are available for management of patients after initiation of these treatments. For corticosteroids, decrease must be very slow on one or two years...
September 2007: Revue Neurologique
https://www.readbyqxmd.com/read/17199956/effect-of-nifekalant-on-acute-electrical-remodelling-in-rapid-atrial-pacing-canine-model
#8
Min Tang, Shu Zhang, Qi Sun, Wei Hua, Cong-xin Huang
BACKGROUND: Nifekalant may prevent atrial fibrillation (AF) and possibly be useful in treatment of atrial tachyarrhythmia in patients with severe heart failure. This study investigated the electophysiologic effect of nifekalant on the acute atrial remodeling in rapid atrial pacing (RAP) model of canine. METHODS: Twelve mongrel dogs subjected to rapid stimulation (400 beats/min) at left atrial appendage (LAA) for 24 hours, were randomized into the control group (rapid pacing only, n = 6) and the nifekalant group (intravenous nifekalant therapy immediately after RAP, n = 6)...
December 20, 2006: Chinese Medical Journal
https://www.readbyqxmd.com/read/15787078/rare-auditory-electophysiology-finding-in-wilson-s-disease
#9
Monte F Hardin, Monty Barker, Paul Neis
Wilson's disease is a rare genetic disease involving the malabsorption of copper by the body. The most common characteristic sign is the presence of Kayser-Fleischner ring surrounding the cornea. Other systemic and motor signs have been documented as well as MRI changes within the brain and brainstem. This rare case illustrates the potential importance of audiometric assessment for patients with Wilson's disease who complain of hearing loss, tinnitus and intra-aural pressure. Unilateral findings were significant for retrocochlear neural transmission delays...
March 2005: Journal of the Arkansas Medical Society
https://www.readbyqxmd.com/read/15332341/melanopsin-shedding-light-on-the-elusive-circadian-photopigment
#10
REVIEW
R Lane Brown, Phyllis R Robinson
Circadian photoentrainment is the process by which the brain's internal clock becomes synchronized with the daily external cycle of light and dark. In mammals, this process is mediated exclusively by a novel class of retinal ganglion cells that send axonal projections to the suprachiasmatic nuclei (SCN), the region of the brain that houses the circadian pacemaker. In contrast to their counterparts that mediate image-forming vision, SCN-projecting RGCs are intrinsically sensitive to light, independent of synaptic input from rod and cone photoreceptors...
March 2004: Chronobiology International
https://www.readbyqxmd.com/read/12778304/-pudendal-neuropathy-correlation-with-demographic-data-severity-index-and-pressoric-parameters-in-patients-with-fecal-incontinence
#11
Luciano Pinto de Carvalho, Oly Campos Corleta, Afonso Calil Mury Mallmann, Ruy Takashi Koshimizu, Alessandro Spolavori
BACKGROUND: Fecal incontinence stands for inability in maintaining the control of defecation to a socially acceptable and adequate time and place, resulting in unwanted release of gas, liquid or solid stool. The diagnosis needs multiple exams. Anorectal manometry is mandatory for this study. The correlation between manometry with electophysiological studies and symptoms is not yet clear in the literature. AIMS: Correlate values of anal manometry, pudental nerve terminal motor latency and co morbidity in fecal incontinence patients...
July 2002: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/12744171/-simulation-application-of-whole-heart-electophysiological-model
#12
Hao Zhu, Bingsheng Yin, Daimo Zhu
We invented an efficiently approach to building whole-heart electrophysiological model with cellular automata style massive parallel computing. In this paper, we introduce the simulation facilities of a model we built and the potential application of such model. The first use is to solve the forward problem of electrocardiogram. Simulating arrhythmia ECG and accurately interpreting the significance of various irregular waveforms will be the key goal. Investigating the dynamic property of cardioelectrical activity at cellular and channel levels is the second application, aiming at revealing the mechanism of the generation and sustentation of arrhythmia...
March 2003: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/10864884/electrophysiological-effects-of-endothelin-1-and-their-relationship-to-contraction-in-rat-renal-arterial-smooth-muscle
#13
L C Betts, R Z Kozlowski
The electophysiological effects of endothelin-1 (ET-1) and their relationship to contraction remain unclear in the renal circulation. Using endotheliumdenuded arteries from the main branch of the renal artery proximal to the kidney of the rat, we have examined its effects on tension and conducted parallel patch-clamp measurements using freshly isolated smooth muscle cells from this tissue. Pharmacological experiments revealed that ET-1 produced constriction of renal arteries dependent on the influx of extracellular Ca(2+), mediated solely through ET(A) receptor stimulation...
June 2000: British Journal of Pharmacology
https://www.readbyqxmd.com/read/10418186/-protective-effect-of-allopurinol-in-the-exposure-to-noise-pulses
#14
G Attanasio, E Cassandro, L Sequino, B Mafera, P Mondola
Free oxygen radicals cause particularly severe tissues and organ damage. They appear to play an important role in the cochlea, mediating noise-exposure damage. In the present study 16 guinea pigs were implanted with permanent electrodes to record cochlear action potential. Eight animals were exposed to a 2-3 kHz, 125 dB SPL noise pulse, at a rate of 4 stimulations per second for 1.8 hours. Prior to noise exposure four out of eight animals were treated with a known dose of allopurinol. The remaining eight animals were used as controls...
February 1999: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/10037722/cloning-of-a-stretch-inhibitable-nonselective-cation-channel
#15
M Suzuki, J Sato, K Kutsuwada, G Ooki, M Imai
A homologue of the capsaicin receptor-nonselective cation channel was cloned from the rat kidney to investigate a mechanosensitive channel. We found this channel to be inactivated by membrane stretch and have designated it stretch-inactivated channel (SIC). SIC encodes a 563-amino acid protein with putative six transmembrane segments. The cDNA was expressed in mammalian cells, and electophysiological studies were performed. SIC-induced large cation currents were found to be regulated by cell volume, with currents being stimulated by cell shrinkage and inhibited by cell swelling...
March 5, 1999: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/9858961/-association-of-an-epsilon-wave-and-syncope
#16
M Aldakar, H Perchet, R Coutte, J Dauptain, J F Lefort, P Charon
BACKGROUND: Epsilon waves, rarely observed in clinical practice, result from late potentials favoring the development of ventricular rhythm disorders by reentry. CASE REPORT: A 53-year-old man with sequellar myocardial infarction experienced a syncope. The surface ECG recorded an epsilon wave. Programmed ventricular stimulation before and after anti-arrhythmia drugs triggered ventricular tachycardia which was hemodynamically poorly tolerated. A defibrillator was implanted and confirmed retrospectively the rhythmic origin of the syncope...
November 28, 1998: La Presse Médicale
https://www.readbyqxmd.com/read/9525053/-treatment-of-paroxysmal-ventricular-tachycardia
#17
G Kaliská, M Szentiványi, I Nedĕlová, P Kmec
The authors present a retrospective evaluation of the risk stratification and therapy of 53 patients with ventricular tachycardia. They present the diagnostical algorithm used for the detection of risk of sudden death. The most frequently used drug in the set of patients was amiodarone in monotherapy or in combination with other drugs. Sotalol was used for both, its antiarrhythmic nature, and for its ability to reduce the defibrillation threshold in patients with an implanted automatic implantable cardiovertor-defibrillator (AICD)...
November 1997: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/8951120/determining-the-maximal-length-of-a-vein-conduit-used-as-an-interposition-graft-for-nerve-regeneration
#18
B Strauch, M Ferder, S Lovelle-Allen, K Moore, D J Kim, J Llena
Although autogenous veins have been used as nerve conduits (AVNCs) both experimentally and clinically for short nerve gaps up to 3 cm, investigators have not as yet determined the maximal effective length for functional nerve regeneration. In addition, the role of the distal nerve stump on subsequent nerve growth remains unclear. A rabbit peroneal nerve AVNC model was used to study axonal regeneration through nerve gaps of 1 to 6 cm. After allowing ample time for nerve regeneration, clinical, electophysiologic and neurohistologic studies were performed to evaluate nerve growth and functional muscle reinnervation...
November 1996: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/8749048/external-ophthalmoplegia-with-ragged-red-fibres-and-acetylcholine-receptor-antibodies
#19
D Mitsikostas, P Manta, N Kalfakis, A Chioni, A Ilias, D Liakopoulos, C Papageorgiou
The cases of two elderly women with external ophthalmoplegia, generalized muscle weakness and serum anti-acetylcholine receptor antibodies, are presented. The electophysiological studies showed a myopathic pattern but no indications of myasthenia after repetitive stimulation. The edrophonium test was negative and there was no response to anticholinesterase medication. In addition, elevated serum lactic acid levels and ragged-red muscle fibres in the muscle biopsy, were observed in both patients. These findings are discussed in relation to the fact that anti-acetylcholine receptor antibodies are diagnostic of myasthenia gravis, whereas ragged-red fibres and elevated lactic acid are correlated with mitochondrial myopathies...
July 1995: Functional Neurology
https://www.readbyqxmd.com/read/7975303/visual-evoked-potentials-in-three-dimensional-color-space-correlates-of-spatio-chromatic-processing
#20
J Rabin, E Switkes, M Crognale, M E Schneck, A J Adams
Visual evoked potentials (VEPs) were measured for sinusoidal gratings with spatio-chromatic modulation defined in a three-dimensional color space. The spatio-chromatic modulation of the gratings can be decomposed into contributions from an achromatic luminance varying component, an isoluminant component which modulates only the activities of L cones and M cones, and an isoluminant component corresponding to modulation of only S-cone activity. The emphasis of this report is the nature of VEPs resulting from isoluminant spatio-chromatic modulation...
October 1994: Vision Research
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