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https://www.readbyqxmd.com/read/24176496/cross-protection-elicited-by-primary-and-booster-vaccinations-against-japanese-encephalitis-a-two-year-follow-up-study
#1
Elina O Erra, Helena Hervius Askling, Sutee Yoksan, Lars Rombo, Jukka Riutta, Sirkka Vene, Lars Lindquist, Olli Vapalahti, Anu Kantele
BACKGROUND: The inactivated Vero cell-derived vaccine (JE-VC, IXIARO) has replaced the traditional mouse brain-derived preparations (JE-MB) in travelers' vaccinations against Japanese encephalitis. We showed recently that a single JE-VC dose efficiently boosts immunity in JE-MB-primed vaccinees, and that JE-VC elicits cross-protective immunity against non-vaccine genotypes, including the emerging genotype I. While these studies only provided short-term data, the present investigation evaluates the longevity of seroprotection in the same volunteers...
December 17, 2013: Vaccine
https://www.readbyqxmd.com/read/23074319/cross-protective-capacity-of-japanese-encephalitis-je-vaccines-against-circulating-heterologous-je-virus-genotypes
#2
Elina O Erra, Helena Hervius Askling, Sutee Yoksan, Lars Rombo, Jukka Riutta, Sirkka Vene, Lars Lindquist, Olli Vapalahti, Anu Kantele
Current Japanese encephalitis vaccines are derived from strains of genotype III, yet heterologous genotypes are emerging in endemic areas. Inactivated vaccines given to European travelers were found to elicit protective levels of neutralizing antibodies against heterologous strains of genotypes I-IV.
January 2013: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/22947427/proinflammatory-cytokines-in-serum-and-cerebrospinal-fluid-of-cidp-patients
#3
Michael Rentzos, Aikaterini V Angeli, Antonis Rombos, Andreas Kyrozis, Chryssoula Nikolaou, Vassiliki Zouvelou, Aikaterini Dimitriou, Margarita Zoga, Maria-Eleni Evangelopoulos, Alexandra Tsatsi, Anthousa Tsoutsou, Ioannis Evdokimidis
INTRODUCTION: Little is known about the role of cytokines in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Interleukin (IL)-12 and IL-15 are the major growth and differentiation factors for Th-1 cells and IL-17 is a marker of Th-17 cell expansion and activation, a high proinflammatory new subset of T cells that induce severe autoimmunity. PATIENTS AND METHODS: We measured by enzyme-like immunosorbent assay serum and cerebrospinal fluid (CSF) levels of IL-15, IL-12, and IL-17 in 24 patients with CIDP and 12 patients with other non-inflammatory neurological disorders and serum levels in 16 healthy subjects...
November 2012: Neurological Research
https://www.readbyqxmd.com/read/22696017/a-single-dose-of-vero-cell-derived-japanese-encephalitis-je-vaccine-ixiaro-effectively-boosts-immunity-in-travelers-primed-with-mouse-brain-derived-je-vaccines
#4
Elina O Erra, Helena Hervius Askling, Lars Rombo, Jukka Riutta, Sirkka Vene, Sutee Yoksan, Lars Lindquist, Sari H Pakkanen, Eili Huhtamo, Olli Vapalahti, Anu Kantele
BACKGROUND: A significant part of the world population lives in areas with endemic Japanese encephalitis (JE). For travelers from nonendemic countries, Vero cell-derived vaccine (JE-VC; Ixiaro) has replaced traditional mouse brain-derived vaccines (JE-MB) associated with safety concerns. The 2 vaccines are derived from different viral strains: JE-VC from the SA14-14-2 strain and JE-MB from the Nakayama strain. No data exist regarding whether JE-VC can be used to boost immunity after a primary series of JE-MB; therefore, a primary series of JE-VC has been recommended to all travelers regardless of previous vaccination history...
September 2012: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/22122857/immunogenicity-of-delayed-tbe-vaccine-booster
#5
H H Askling, S Vene, L Rombo, L Lindquist
Information is scarce regarding the antibody response when TBE-vaccine booster doses are delayed, which is a common situation in daily life. We have investigated the immune response after a delayed booster dose compared to a normal booster interval in an every-day setting. Overall, 250/260 (96%) of the study participants had neutralizing antibodies post-booster, with no significant difference between normal and delayed booster intervals. Based on our findings we propose that healthy individuals who have failed adherence to the recommended schedule of TBE-vaccination can be given a delayed dose without concern of immunogenicity...
January 11, 2012: Vaccine
https://www.readbyqxmd.com/read/18976327/circulating-interleukin-10-and-interleukin-12-in-parkinson-s-disease
#6
M Rentzos, C Nikolaou, E Andreadou, G P Paraskevas, A Rombos, M Zoga, A Tsoutsou, F Boufidou, E Kapaki, D Vassilopoulos
BACKGROUND: Interleukin (IL)-12 is a heterodimeric cytokine produced by activated blood monocytes, macrophages and glial cells. It enhances differentiation and proliferation of T cells and increases production of proinflammatory cytokines. IL-10 is a pleiotropic cytokine produced by both lymphocytes and mononuclear phagocytes including microglia. Recent studies demonstrated the neuroprotective effect of IL-10. There is little information about the involvement of IL-12 or IL-10 in the pathophysiology of Parkinson's disease (PD)...
May 2009: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/17986095/circulating-interleukin-15-and-rantes-chemokine-in-parkinson-s-disease
#7
M Rentzos, C Nikolaou, E Andreadou, G P Paraskevas, A Rombos, M Zoga, A Tsoutsou, F Boufidou, E Kapaki, D Vassilopoulos
UNLABELLED: Interleukin-15 promotes T-cell proliferation, induction of cytolytic effector cells including natural killer (NK) and cytotoxic cells and stimulates B-cell to proliferate and secrete immunoglobulins. RANTES is a C-C beta chemokine with strong chemoattractant activity for T lymphocytes and monocytes. OBJECTIVES: The objective of our study was to find out whether IL-15 and RANTES are involved in the possible inflammatory reactions of PD. PATIENTS AND METHODS: We measured by immunoassay serum IL-15 and RANTES levels in 41 patients with PD in comparison with serum levels in 19 healthy subjects age and sex-matched...
December 2007: Acta Neurologica Scandinavica
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