keyword
https://read.qxmd.com/read/37824391/comprehensive-characterization-of-hats-and-hdacs-in-human-cancers-reveals-their-role-in-immune-checkpoint-blockade
#21
JOURNAL ARTICLE
Rong Sun, Zike Chen, Xuanhao Qu, Jie Zhang, Lehan Liu, Zhuheng Zhong, Weibing Zhang, Yihui Fan
Histone acetylation that controlled by two mutually antagonistic enzyme families, histone acetyl transferases (HATs) and histone deacetylases (HDACs), as one of major epigenetic mechanisms controls transcription and its abnormal regulation was implicated in various aspects of cancer. However, the comprehensive understanding of HDACs and HATs in cancer is still lacking. Systematically analysis through 33 cancer types based on next-generation sequence data reveals heterogeneous expression pattern of HDACs and HATs across different cancer types...
2024: Critical Reviews in Eukaryotic Gene Expression
https://read.qxmd.com/read/37818566/hdac9-as-a-privileged-target-reviewing-its-role-in-different-diseases-and-structure-activity-relationships-sars-of-its-inhibitors
#22
JOURNAL ARTICLE
Totan Das, Samima Khatun, Tarun Jha, Shovanlal Gayen
HDAC9 is a histone deacetylase enzyme belonging to the class IIa of HDACs which catalyses histone deacetylation. HDAC9 inhibit cell proliferation by repairing DNA, arresting the cell cycle, inducing apoptosis, and altering genetic expression. HDAC9 plays a significant part in human physiological system and are involved in various type of diseases like cancer, diabetes, atherosclerosis and CVD, autoimmune response, inflammatory disease, osteoporosis and liver fibrosis. This review discusses the role of HDAC9 in different diseases and structure-activity relationships (SARs) of various hydroxamate and non-hydroxamate-based inhibitors...
October 5, 2023: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/37748211/hdac9-p300-f-actin-immunoexpression-and-migration-analysis-for-malignant-melanoma-stem-cell
#23
JOURNAL ARTICLE
Merve Ozdemir, Berrin Ozdil, Cemile Sinem Asker Abdikan, Derya Erisik, Taha Kadir Yesin, Cıgır Biray Avci, Yesim Kurkutçu, Gunnur Guler, Huseyin Aktug
Melanoma is an aggressive tumor with a poor prognosis that worsens in the metastatic phase. Distruptions of epigenetic mechanisms is known to effect cancer stem cells (CSCs) activity. Malignant melanoma (MM) progression may be promoted by changes in the genetic structure of CSC. Thus, treatments that target epigenetic modifications could be a promising weapon, especially in melanoma. Here, we compared p300, HDAC9, and F-actin proteins in melanoma CSCs (CD133+), non-CSCs (CD133-) and CHL-1 cell line, as well as cell migration and division rates...
September 22, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/37690046/upregulation-of-hdac9-in-hippocampal-neurons-mediates-depression-like-behaviours-by-inhibiting-anxa2-degradation
#24
JOURNAL ARTICLE
Yunjian Dai, Taofeng Wei, Yuwen Huang, Yun Bei, Haoran Lin, Zexu Shen, Lingyan Yu, Mingdong Yang, Huimin Xu, Wei He, Zheng Lin, Haibin Dai
Major depressive disorder (MDD) is a pervasive and devastating mental disease. Broad spectrum histone deacetylase (HDAC) inhibitors are considered to have potential for the treatment of depressive phenotype in mice. However, due to its non-specific inhibition, it has extensive side effects and can not be used in clinical treatment of MDD. Therefore, finding specific HDAC subtypes that play a major role in the etiology of MDD is the key to develop corresponding specific inhibitors as antidepressants in the future...
September 10, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37688590/histone-deacetylase-9-plays-a-role-in-sevoflurane-induced-neuronal-differentiation-inhibition-by-inactivating-camp-response-element-binding-protein-transcription-and-inhibiting-the-expression-of-neurotrophin-3
#25
JOURNAL ARTICLE
Xinlei Li, Gongming Wang, Wei Li, Xu Wang, Jiangnan Wu, Yingxue He, Xiaowei Li, Xiaobin Sun, Mengyuan Zhang, Yanjing Guo
Postoperative cognitive decline (POCD) is a common and serious complication following anesthesia and surgery; however, the precise mechanisms of POCD remain unclear. Our previous research showed that sevoflurane impairs adult hippocampal neurogenesis (AHN) and thus cognitive function in the aged brain by affecting neurotrophin-3 (NT-3) expression; however, the signaling mechanism involved remains unexplored. In this study, we found a dramatic decrease in the proportion of differentiated neurons with increasing concentrations of sevoflurane, and the inhibition of neural stem cell differentiation was partially reversed after the administration of exogenous NT-3...
October 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/37636966/differences-and-similarities-between-colorectal-cancer-cells-and-colorectal-cancer-stem-cells-molecular-insights-and-implications
#26
JOURNAL ARTICLE
Derya Erisik, Berrin Ozdil, Eda Acikgoz, Cemile Sinem Asker Abdikan, Taha Kadir Yesin, Huseyin Aktug
Malignant tumors are formed by diverse groups of cancer cells. Cancer stem cells (CSCs) are a subpopulation of heterogeneous cells identified in tumors that have the ability to self-renew and differentiate. Colorectal cancer (CRC), the third most frequent malignant tumor, is progressively being supported by evidence suggesting that CSCs are crucial in cancer development. We aim to identify molecular differences between CRC cells and CRC CSCs, as well as the effects of those differences on cell behavior in terms of migration, EMT, pluripotency, morphology, cell cycle/control, and epigenetic characteristics...
August 22, 2023: ACS Omega
https://read.qxmd.com/read/37625608/gypenoside-xvii-inhibits-ox-ldl-induced-macrophage-inflammatory-responses-and-promotes-cholesterol-efflux-through-activating-the-mir-182-5p-hdac9-signaling-pathway
#27
JOURNAL ARTICLE
Wen-Yi Deng, Cheng-Long Zhou, Meng-Ya Zeng
ETHNOPHARMACOLOGICAL RELEVANCE: The deposition of lipids in macrophages and the subsequent formation of foam cells significantly increase the risk of developing atherosclerosis (AS). Targeting ATP-binding cassette transporter A1/B1-mediated reverse cholesterol transport is crucial for regulating foam cell formation. Therefore, the search for natural chemical components with the ability to regulate ABCA1/G1 is a potential drug target to combat the development of atherosclerosis. Gypenoside XVII (GP-17), a gypenoside monomer extracted from gynostemma pentaphyllum, presents an efficient anti-atherosclerosis function...
August 23, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37573538/aberrant-expression-and-regulatory-role-of-histone-deacetylase-9-in-vascular-endothelial-cell-injury-in-intracranial-aneurysm
#28
JOURNAL ARTICLE
Jingwei Sun, Langfeng Zhang, Quanjiang Cheng, Yajun Wu
Intracranial aneurysm (IA) is one of the most challenging cerebrovascular lesions for clinicians. The aim of this study was to investigate the abnormal expression and role of histone deacetylase 9 (HDAC9) in IA-associated injury of vascular endothelial cells (VECs). First, IA tissue and normal arterial tissue were collected and VECs were isolated from IA patients. The expression levels of HDAC9, microRNA (miR)-34a-5p, and vascular endothelial growth factor-A (VEGFA) were determined. Cell viability, proliferation, apoptosis, and migration were assessed by Cell Counting Kit-8 (CCK-8) assay, EdU staining, TUNEL staining, and transwell assay...
August 12, 2023: Biomol Biomed
https://read.qxmd.com/read/37528157/hdac1-and-hdac6-are-essential-for-driving-growth-in-idh1-mutant-glioma
#29
JOURNAL ARTICLE
Matthew C Garrett, Rebecca Albano, Troy Carnwath, Lubayna Elahi, Catherine A Behrmann, Merissa Pemberton, Daniel Woo, Eric O'Brien, Brett VanCauwenbergh, John Perentesis, Sanjit Shah, Matthew Hagan, Ady Kendler, Chuntao Zhao, Aditi Paranjpe, Krishna Roskin, Harley Kornblum, David R Plas, Q Richard Lu
Low-grade and secondary high-grade gliomas frequently contain mutations in the IDH1 or IDH2 metabolic enzymes that are hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. Histone deacetylase inhibitors are promising anti-cancer agents and have already been used in clinical trials. However, a clear understanding of their mechanism or gene targets is lacking. In this study, the authors genetically dissect patient-derived IDH1 mutant cultures to determine which HDAC enzymes drive growth in IDH1 mutant gliomas...
August 1, 2023: Scientific Reports
https://read.qxmd.com/read/37484002/monitoring-mrna-expression-patterns-in-macrophages-in-response-to-two-different-strains-of-probiotics
#30
JOURNAL ARTICLE
Sang-Pil Choi, Si-Won Park, Seok-Jin Kang, Seul Ki Lim, Min-Sung Kwon, Hak-Jong Choi, Taehoon Chun
As an initial study to elucidate the molecular mechanism of how probiotics modulate macrophage activity, we monitored mRNA expression patterns in peritoneal macrophages (PMs) treated with two different strains of probiotics. After treatment with either Weissella cibaria WIKIM28 or Latilactobacillus sakei WIKIM50, total RNAs from PMs were isolated and subjected into gene chip analyses. As controls, mRNAs from vehicle (phosphate-buffered saline, PBS)-treated PMs were also subjected to gene chip analysis. Compared to vehicle (PBS)-treated PMs, WIKIM28-treated and WIKIM50-treated PMs exhibited a total of 889 and 432 differentially expressed genes with expression differences of at least 4 folds, respectively...
July 2023: Food science of animal resources
https://read.qxmd.com/read/37424350/tropolones-and-thailandepsin-b-as-lead-like-natural-compounds-in-the-development-of-potent-and-selective-histone-deacetylase-inhibitors
#31
JOURNAL ARTICLE
Dilipkumar Pal, Padum Lal
BACKGROUND: Tropolone and thailandepsin B are naturally occurring substances that are primarily isolated from fungi and plants, although they can also be found in certain bacteria. Tropolones belong to an important class of aromatic compounds with a seven-membered nonbenzenoid ring structure. Thailandepsins are a group of natural products that were initially discovered in the culture broth of the Gram-negative bacterium Burkholderia thailandensis. Tropolonebased structures have been identified in over 200 natural compounds, ranging from simple tropolone derivatives to complex multicyclic systems like pycnidione and pyrerubrine A...
2023: Current Drug Targets
https://read.qxmd.com/read/37324938/stroke-by-inducing-hdac9-dependent-deacetylation-of-hif-1-and-sp1-promotes-tfr1-transcription-and-gpx4-reduction-thus-determining-ferroptotic-neuronal-death
#32
JOURNAL ARTICLE
Luca Sanguigno, Natascia Guida, Serenella Anzilotti, Ornella Cuomo, Luigi Mascolo, Angelo Serani, Paola Brancaccio, Giuseppina Pennacchio, Ester Licastro, Giuseppe Pignataro, Pasquale Molinaro, Lucio Annunziato, Luigi Formisano
Background: The inhibition of histone deacetylase 9 (HDAC9) represents a promising druggable target for stroke intervention. Indeed, HDAC9 is overexpressed in neurons after brain ischemia where exerts a neurodetrimental role. However, mechanisms of HDAC9-dependent neuronal cell death are not yet well established. Methods: Brain ischemia was obtained in vitro by primary cortical neurons exposed to glucose deprivation plus reoxygenation (OGD/Rx) and in vivo by transient middle cerebral artery occlusion. Western blot and quantitative real-time polymerase chain reaction were used to evaluate transcript and protein levels...
2023: International Journal of Biological Sciences
https://read.qxmd.com/read/37280359/three-generation-families-analysis-of-de-novo-variants-in-autism
#33
JOURNAL ARTICLE
Claudia I Samogy Costa, Gabriele da Silva Campos, Eduarda Morgana da Silva Montenegro, Jaqueline Yu Ting Wang, Marília Scliar, Frederico Monfardini, Elaine Cristina Zachi, Naila C V Lourenço, Ada J S Chan, Sergio L Pereira, Worrawat Engchuan, Bhooma Thiruvahindrapuram, Mehdi Zarrei, Stephen W Scherer, Maria Rita Passos-Bueno
De novo variants (DNVs) analysis has proven to be a powerful approach to gene discovery in Autism Spectrum Disorder (ASD), which has not yet been shown in a Brazilian ASD cohort. The relevance of inherited rare variants has also been suggested, particularly in oligogenic models. We hypothesized that three-generation analyses of DNVs could provide new insights into the relevance of de novo and inherited variants across generations. To accomplish this goal, we performed whole-exome sequencing of 33 septet families composed of probands, parents, and grandparents (n = 231 individuals) and compared DNV rates (DNVr) between generations and those from two control cohorts...
June 6, 2023: European Journal of Human Genetics: EJHG
https://read.qxmd.com/read/37262978/role-of-histone-deacetylase-9-in-human-periodontal-ligament-stem-cells-autophagy-in-a-tumour-necrosis-factor-%C3%AE-induced-inflammatory-environment
#34
JOURNAL ARTICLE
Wenbin Ge, Shitong Luo, Kun Zhang, Lizhiyi Liu, Zhi Zhou, Yali Liu
Histone deacetylases (HDACs) play important roles in the post-translational modification of histones, which can affect the biological properties of cells, thereby altering disease progression and outcomes. However, it remains unclear how HDAC9, a class II HDAC, affects the autophagy of human periodontal ligament stem cells (hPDLSCs). We aimed to identify its role in autophagy in hPDLSCs in an inflammatory environment and to explore the potential regulatory mechanisms. A rat periodontitis model was induced by ligating the molars with silk thread...
May 17, 2023: Tissue & Cell
https://read.qxmd.com/read/37250142/mir-101-3p-improves-neuronal-morphology-and-attenuates-neuronal-apoptosis-in-ischemic-stroke-in-young-mice-by-downregulating-hdac9
#35
JOURNAL ARTICLE
Mengru Zhang, Jianjun Wang, Jinfang Li, Fanxin Kong, Songjun Lin
OBJECTIVE: MiRNAs play a key role in ischemic stroke (IS). Although miR-101-3p can participate in multiple disease processes, its role and mechanism in IS are not clear. The aim of the present study was to observe the effect of miR-101-3p activation on IS in young mice and the role of HDAC9 in this effect. METHODS: The young mice were first subjected to transient middle cerebral artery occlusion (tMCAO) or sham surgery, and the cerebral infarct area was assessed with 2,3,5-triphenyltetrazolium chloride staining...
January 1, 2023: Translational Neuroscience
https://read.qxmd.com/read/37230975/hdac9-mediated-epithelial-cell-cycle-arrest-in-g2-m-contributes-to-kidney-fibrosis-in-male-mice
#36
JOURNAL ARTICLE
Yang Zhang, Yujie Yang, Fan Yang, Xiaohan Liu, Ping Zhan, Jichao Wu, Xiaojie Wang, Ziying Wang, Wei Tang, Yu Sun, Yan Zhang, Qianqian Xu, Jin Shang, Junhui Zhen, Min Liu, Fan Yi
Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are involved in G2/M arrest of TECs remain unclear. Here, we find that Hdac9 expression is significantly induced in the mouse fibrotic kidneys, especially in proximal tubules, induced by aristolochic acid nephropathy (AAN) or unilateral ureter obstruction (UUO). Tubule-specific deletion of HDAC9 or pharmacological inhibition by TMP195 attenuates epithelial cell cycle arrest in G2/M, then reduces production of profibrotic cytokine and alleviates tubulointerstitial fibrosis in male mice...
May 25, 2023: Nature Communications
https://read.qxmd.com/read/37193176/a-necroptosis-gene-signature-predicts-prostate-cancer-recurrence-and-is-linked-to-somatic-mutation-therapeutic-landscape-and-immune-infiltration
#37
JOURNAL ARTICLE
Yibing Wang, Xiali Zhang, Lidong Wu, Qian Feng, Zhiqiang Luo, Tao Zeng, Jun Luo
OBJECTIVE: Necroptosis, a type of programmed necrotic cell death, has been implicated in cancer biology and therapeutics. Improved risk stratification is required for prostate carcinoma in individuals. In view of the importance of necroptosis, this work proposed a necroptosis-based genetic model for recurrence prediction, and clarified its characteristics. METHODS: A least absolute shrinkage and selection operator (LASSO) regression analysis was conducted based upon transcriptome data of necroptosis genes with clinical information in the Cancer Genome Atlas (TCGA) prostate carcinoma samples, which were externally verified in the GSE116918 cohort...
2023: American Journal of Translational Research
https://read.qxmd.com/read/36927982/knockdown-of-hdac9-attenuates-sepsis-induced-myocardial-injury-and-inflammatory-response
#38
JOURNAL ARTICLE
Long Yang, Chunxue Wu, Ying Cui, Shimin Dong
Myocardial cell damage is associated with apoptosis and excessive inflammatory response in sepsis. Histone deacetylases (HDACs) are implicated in the progression of heart diseases. This study aims to explore the role of histone deacetylase 9 (HDAC9) in sepsis-induced myocardial injury. Lipopolysaccharide (LPS)-induced Sprague Dawley rats and cardiomyocyte line H9C2 were used as models in vivo and in vitro. The results showed that HDAC9 was significantly upregulated after LPS stimulation, and HDAC9 knockdown remarkably improved cardiac function, as evidenced by decreased LVEDD and LVESD, and increased FS% and EF%...
March 13, 2023: Experimental Animals
https://read.qxmd.com/read/36857949/the-expression-of-hdac9-and-p300-in-papillary-thyroid-carcinoma-cell-line
#39
JOURNAL ARTICLE
Hatice Ozisik, Berrin Ozdil, Aslı Suner, Murat Sipahi, Mehmet Erdogan, Sevki Cetinkalp, Gokhan Ozgen, Fusun Saygili, Gulgun Oktay, Huseyin Aktug
PURPOSE: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and accounts for 85-90% of all thyroid cancers. Metastatic differentiated thyroid cancer, radioiodine-refractory thyroid cancer, and anaplastic thyroid cancer still lack effective therapeutic options. Here, we aimed to assess HDAC9 and P300 expression in the papillary thyroid carcinoma cell line and compare them with normal thyroid cells. METHODS: Nthy-ori-3-1, a normal thyroid cell line, and BCPAP, a PTC cell line, were cultured for 24 and 48 h and immunofluorescence staining was used to determine the levels of HDAC9 and P300 protein expression...
February 24, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/36846594/validating-expression-of-beta-cell-maturation-associated-genes-in-human-pancreas-development
#40
JOURNAL ARTICLE
Daniel M Tremmel, Anna E Mikat, Sakar Gupta, Samantha A Mitchell, Andrew M Curran, Jenna A Menadue, Jon S Odorico, Sara Dutton Sackett
The identification of genes associated with human pancreatic beta cell maturation could stimulate a better understanding of normal human islet development and function, be informative for improving stem cell-derived islet (SC-islet) differentiation, and facilitate the sorting of more mature beta cells from a pool of differentiated cells. While several candidate factors to mark beta cell maturation have been identified, much of the data supporting these markers come from animal models or differentiated SC-islets...
2023: Frontiers in Cell and Developmental Biology
keyword
keyword
7742
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.